Pub Date : 2024-11-14DOI: 10.1016/j.prevetmed.2024.106365
K Chalkowski, K M Pepin, M J Lavelle, R S Miller, J Fischer, V R Brown, M Glow, B Smith, S Cook, K Kohen, S Sherburne, H Smith, B Leland, K C VerCauteren, N P Snow
Transboundary animal disease (TAD) introductions can have myriad economic, ecological, and societal impacts. When TADs are introduced into wild species, rapid and intense control efforts to reduce wild animal host populations are sometimes needed to eliminate the disease and prevent endemicity and spillover to domestic animal populations. Yet, such intensive efforts are non-trivial, and the rarity of TAD introductions means that personnel rarely have direct experience with these types of operations. Thus, explicit assessments of operational challenges for these kinds of efforts can provide direction to build emergency response preparedness capacity. Here, we simulated a TAD control effort in response to initial detection of a hypothetical index case of a TAD in wild pigs (Sus scrofa) (e.g., African swine fever; ASF). We used three removal methods (aerial control, trapping, and an experimental toxic bait). Then, we conducted an after-action assessment to identify operational challenges for rapidly reducing a population of invasive wild pigs within a simulated outbreak zone. We also simulated carcass recoveries of dispatched pigs, similar to what might be conducted during a response to a TAD with carcass-based transmission (e.g., ASF virus). Here, we describe operational challenges identified during our effort, alongside technological development solutions and a priori strategy needs to improve TAD response operation outcomes.
跨界动物疾病（TAD）的引入会对经济、生态和社会产生无数影响。当 TAD 被引入野生物种时，有时需要采取快速、密集的控制措施来减少野生动物宿主的数量，以消除疾病并防止其流行和蔓延到家畜种群。然而，这种高强度的工作并非易事，而且 TAD 的引入非常罕见，这意味着工作人员很少有此类行动的直接经验。因此，对这类工作的操作挑战进行明确评估可以为建立应急响应准备能力提供方向。在此，我们模拟了在野猪（Sus scrofa）中初步检测到假定的 TAD 指数病例（如非洲猪瘟；ASF）时的 TAD 控制工作。我们采用了三种清除方法（空中控制、诱捕和试验性毒饵）。然后，我们进行了事后评估，以确定在模拟疫区内迅速减少入侵野猪数量所面临的操作挑战。我们还模拟了对被驱赶野猪的尸体回收，这与应对以尸体为基础的传播（如 ASF 病毒）的 TAD 时可能采取的措施类似。在此，我们将介绍在我们的工作中发现的操作挑战，以及技术开发解决方案和先验策略需求，以改善 TAD 响应操作结果。
{"title":"Operational lessons learned from simulating an elimination response to a transboundary animal disease in wild animals.","authors":"K Chalkowski, K M Pepin, M J Lavelle, R S Miller, J Fischer, V R Brown, M Glow, B Smith, S Cook, K Kohen, S Sherburne, H Smith, B Leland, K C VerCauteren, N P Snow","doi":"10.1016/j.prevetmed.2024.106365","DOIUrl":"https://doi.org/10.1016/j.prevetmed.2024.106365","url":null,"abstract":"<p><p>Transboundary animal disease (TAD) introductions can have myriad economic, ecological, and societal impacts. When TADs are introduced into wild species, rapid and intense control efforts to reduce wild animal host populations are sometimes needed to eliminate the disease and prevent endemicity and spillover to domestic animal populations. Yet, such intensive efforts are non-trivial, and the rarity of TAD introductions means that personnel rarely have direct experience with these types of operations. Thus, explicit assessments of operational challenges for these kinds of efforts can provide direction to build emergency response preparedness capacity. Here, we simulated a TAD control effort in response to initial detection of a hypothetical index case of a TAD in wild pigs (Sus scrofa) (e.g., African swine fever; ASF). We used three removal methods (aerial control, trapping, and an experimental toxic bait). Then, we conducted an after-action assessment to identify operational challenges for rapidly reducing a population of invasive wild pigs within a simulated outbreak zone. We also simulated carcass recoveries of dispatched pigs, similar to what might be conducted during a response to a TAD with carcass-based transmission (e.g., ASF virus). Here, we describe operational challenges identified during our effort, alongside technological development solutions and a priori strategy needs to improve TAD response operation outcomes.</p>","PeriodicalId":20413,"journal":{"name":"Preventive veterinary medicine","volume":"234 ","pages":"106365"},"PeriodicalIF":2.2,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-14DOI: 10.1016/j.prevetmed.2024.106380
Amir Abdoli , Meysam Olfatifar , Leila Zaki , Ali Asghari , Kareem Hatam-Nahavandi , Oskar Nowak , Majid Pirestani , Daniel Diaz , Mohammad Ghaffari Cherati , Aida Vafae Eslahi , Milad Badri , Panagiotis Karanis
Microsporidia are intracellular parasites with significant impact on both animal and human health. The prevalence of microsporidia infections in rabbits, including the genera Enterocytozoon and Encephalitozoon, underscores the importance of understanding their epidemiology for effective control strategies. This systematic review and meta-analysis estimated the global prevalence of microsporidia infection in rabbits using five databases (Scopus, PubMed, Embase, Web of Science, and Google Scholar) to retrieve articles published between 03 December 2003 and 26 March 2023. The global prevalence was estimated with a 95 % confidence interval. All statistical analyses conducted were based on meta-package of R (version 3.6.1). A p-value lower than 0.05 was interpreted as statistically significant. A total of 71 studies comprising 72 datasets were included, yielding a global pooled prevalence of microsporidia infections in rabbits at 0.312 (0.250–0.378). The prevalence varied significantly by continent with highest observed in North America (0.495, 0.151–0.842). Slovenia had the highest pooled prevalence (0.714, 0.654–0.773). Encephalitozoon cuniculi accounted for the highest prevalence (0.338, 0.271–0.407). The findings highlight the global distribution of microsporidia in rabbit populations, emphasizing the zoonotic potential and public health implications. The predominance of E. cuniculi underscores its importance as a widespread pathogen affecting both animal and human health. The data underscore the need for continued surveillance and monitoring, particularly in regions with high prevalence.
小孢子虫是对动物和人类健康有重大影响的细胞内寄生虫。兔子小孢子虫感染（包括肠孢子虫属和脑孢子虫属）的流行，凸显了了解其流行病学以制定有效控制策略的重要性。本系统综述和荟萃分析利用五个数据库（Scopus、PubMed、Embase、Web of Science 和 Google Scholar）检索了 2003 年 12 月 3 日至 2023 年 3 月 26 日期间发表的文章，估算了兔子小孢子虫感染的全球流行率。对全球流行率进行了估计，置信区间为 95%。所有统计分析均基于 R 元软件包（3.6.1 版）。P 值低于 0.05 即为具有统计学意义。共纳入了 71 项研究和 72 个数据集，得出兔子小孢子虫感染的全球总流行率为 0.312（0.250-0.378）。各大洲的流行率差异很大，北美洲的流行率最高（0.495，0.151-0.842）。斯洛文尼亚的总体流行率最高（0.714，0.654-0.773）。阴沟脑虫的流行率最高（0.338，0.271-0.407）。研究结果突显了微孢子虫在兔群中的全球分布，强调了人畜共患的可能性和对公共卫生的影响。阴沟肠杆菌占主导地位，凸显了其作为影响动物和人类健康的广泛病原体的重要性。这些数据强调了持续监测和监控的必要性，尤其是在高流行率地区。
{"title":"The global prevalence of microsporidia infection in rabbits as a neglected public health concern: A systematic review and meta-analysis","authors":"Amir Abdoli , Meysam Olfatifar , Leila Zaki , Ali Asghari , Kareem Hatam-Nahavandi , Oskar Nowak , Majid Pirestani , Daniel Diaz , Mohammad Ghaffari Cherati , Aida Vafae Eslahi , Milad Badri , Panagiotis Karanis","doi":"10.1016/j.prevetmed.2024.106380","DOIUrl":"10.1016/j.prevetmed.2024.106380","url":null,"abstract":"<div><div>Microsporidia are intracellular parasites with significant impact on both animal and human health. The prevalence of microsporidia infections in rabbits, including the genera <em>Enterocytozoon</em> and <em>Encephalitozoon</em>, underscores the importance of understanding their epidemiology for effective control strategies. This systematic review and meta-analysis estimated the global prevalence of microsporidia infection in rabbits using five databases (Scopus, PubMed, Embase, Web of Science, and Google Scholar) to retrieve articles published between 03 December 2003 and 26 March 2023. The global prevalence was estimated with a 95 % confidence interval. All statistical analyses conducted were based on meta-package of R (version 3.6.1). A <em>p</em>-value lower than 0.05 was interpreted as statistically significant. A total of 71 studies comprising 72 datasets were included, yielding a global pooled prevalence of microsporidia infections in rabbits at 0.312 (0.250–0.378). The prevalence varied significantly by continent with highest observed in North America (0.495, 0.151–0.842). Slovenia had the highest pooled prevalence (0.714, 0.654–0.773). <em>Encephalitozoon cuniculi</em> accounted for the highest prevalence (0.338, 0.271–0.407). The findings highlight the global distribution of microsporidia in rabbit populations, emphasizing the zoonotic potential and public health implications. The predominance of <em>E. cuniculi</em> underscores its importance as a widespread pathogen affecting both animal and human health. The data underscore the need for continued surveillance and monitoring, particularly in regions with high prevalence.</div></div>","PeriodicalId":20413,"journal":{"name":"Preventive veterinary medicine","volume":"234 ","pages":"Article 106380"},"PeriodicalIF":2.2,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-12DOI: 10.1016/j.prevetmed.2024.106382
Anne Meyer , Bakary Ndiaye , Andrew Larkins , Gemma Chaters , William Gilbert , Benjamin Huntington , Guy Ilboudo , Michel Dione , Wudu Temesgen Jemberu , Mame Nahé Diouf , Assane Gueye Fall , Mathioro Fall , Mbargou Lo , Jonathan Rushton
Small ruminant production in sub-Saharan Africa is limited by a range of constraints, including animal health issues. This study aimed at estimating the impact of these issues on the small ruminant production in Senegal in a holistic manner, using an approach developed by the Global Burden of Animal Diseases (GBADs) programme. The estimation focused on the mixed crop-livestock system, representing a large proportion (>60 %) of the small ruminant population in the country. It was based on existing data collected via a systematic literature review, acquisition of secondary datasets from local stakeholders, and expert elicitation. A dynamic population model was used to calculate the gross margin of the sector under both the current health constraints and an ideal health state, where animals are not exposed to causes of morbidity and mortality. The difference between the current and ideal health scenarios, termed the Animal Health Loss Envelope (AHLE), provides a quantitative measure of the farm-level cost of disease in the system. The all-cause AHLE was estimated at 292 billion FCFA (468 million USD, with 95 % prediction interval 216 – 366 billion FCFA) per year for 2022, for a population of 8.8 million animals. The contribution of Peste des Petits Ruminants (PPR) was modelled separately, as an example of attributing part of the AHLE to a specific disease cause. PPR was estimated to contribute 5 % of the total AHLE. The animal disease burden experienced by Senegalese livestock keepers was largely due to loss in animals and production, with relatively small amounts of animal health expenditure. Implementation of this study contributed to the further development of the GBADs approach. Such estimates can support decision making at all levels, from investment decisions at the international level to local disease awareness campaigns targeting livestock keepers.
{"title":"Economic assessment of animal disease burden in Senegalese small ruminants","authors":"Anne Meyer , Bakary Ndiaye , Andrew Larkins , Gemma Chaters , William Gilbert , Benjamin Huntington , Guy Ilboudo , Michel Dione , Wudu Temesgen Jemberu , Mame Nahé Diouf , Assane Gueye Fall , Mathioro Fall , Mbargou Lo , Jonathan Rushton","doi":"10.1016/j.prevetmed.2024.106382","DOIUrl":"10.1016/j.prevetmed.2024.106382","url":null,"abstract":"<div><div>Small ruminant production in sub-Saharan Africa is limited by a range of constraints, including animal health issues. This study aimed at estimating the impact of these issues on the small ruminant production in Senegal in a holistic manner, using an approach developed by the Global Burden of Animal Diseases (GBADs) programme. The estimation focused on the mixed crop-livestock system, representing a large proportion (>60 %) of the small ruminant population in the country. It was based on existing data collected via a systematic literature review, acquisition of secondary datasets from local stakeholders, and expert elicitation. A dynamic population model was used to calculate the gross margin of the sector under both the current health constraints and an ideal health state, where animals are not exposed to causes of morbidity and mortality. The difference between the current and ideal health scenarios, termed the Animal Health Loss Envelope (AHLE), provides a quantitative measure of the farm-level cost of disease in the system. The all-cause AHLE was estimated at 292 billion FCFA (468 million USD, with 95 % prediction interval 216 – 366 billion FCFA) per year for 2022, for a population of 8.8 million animals. The contribution of Peste des Petits Ruminants (PPR) was modelled separately, as an example of attributing part of the AHLE to a specific disease cause. PPR was estimated to contribute 5 % of the total AHLE. The animal disease burden experienced by Senegalese livestock keepers was largely due to loss in animals and production, with relatively small amounts of animal health expenditure. Implementation of this study contributed to the further development of the GBADs approach. Such estimates can support decision making at all levels, from investment decisions at the international level to local disease awareness campaigns targeting livestock keepers.</div></div>","PeriodicalId":20413,"journal":{"name":"Preventive veterinary medicine","volume":"234 ","pages":"Article 106382"},"PeriodicalIF":2.2,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abortion imposes a substantial economic burden on the global small ruminant industry, not only reducing herd productivity but also contributing to the spread of zoonotic diseases. This study examines the primary factors associated with abortion, both infectious and non-infectious, in 623 goat herds across Iran. A comprehensive evaluation was performed, incorporating herd history, laboratory results, and statistical analyses using univariate tests and multivariable binary logistic regression. Key findings revealed significant associations with abortion, including previous abortion history, gestational age of the aborted foetus, routine veterinary visits, mineral supplementation, and vaccination practices. Non-infectious factors, such as pregnancy toxemia, goiter, and deficiencies in vitamin E/selenium, were identified in herds with a low abortion prevalence (<10 %). Among the 623 herds studied, 277 (44.5 %) exhibited an abortion prevalence below 2 %, considered within normal limits, while the remaining 346 herds (55.5 %) experienced pathological abortion rates exceeding 2 %. The definitive cause of abortion was determined in 227 of the 346 abortion outbreaks analysed, accounting for 65.6 % of the cases. Infectious agents were identified in 40.7 % of the herds with abortion rates exceeding 2 %, with Brucella melitensis (9.5 %), Chlamydia abortus (7.8 %), and Coxiella burnetii (5.2 %) being the most prevalent pathogens. Multivariable binary logistic regression analysis revealed significant associations between abortion and several factors, including birth (OR=2.01, 95 % CI: 1.05–3.89, P=0.036), previous abortion history (OR=14.5, 95 % CI: 6.01–37.3, P<0.001), gestational age of the aborted foetus (OR=3.07, 95 % CI: 1.63–5.89, P<0.001), routine veterinary visits (OR=0.16, 95 % CI: 0.09–0.27, P<0.001), vaccination (OR=0.25, 95 % CI: 0.11–0.53, P<0.001), and mineral supplementation (OR=0.36, 95 % CI: 0.21–0.62, P<0.001). These findings underscore the diverse causes of abortion in Iranian goat herds, emphasizing the need to improve farmer awareness and access to commercial vaccines targeting infectious abortion agents to enhance herd productivity.
{"title":"Causes of abortion in Iranian goat herds and associated risk factors","authors":"Hossein Esmaeili , Mohammadreza Ghorani , Zeinab Hamidiya , Seyed Mehdi Joghataei , Sergio Villanueva-Saz , Delia Lacasta","doi":"10.1016/j.prevetmed.2024.106381","DOIUrl":"10.1016/j.prevetmed.2024.106381","url":null,"abstract":"<div><div>Abortion imposes a substantial economic burden on the global small ruminant industry, not only reducing herd productivity but also contributing to the spread of zoonotic diseases. This study examines the primary factors associated with abortion, both infectious and non-infectious, in 623 goat herds across Iran. A comprehensive evaluation was performed, incorporating herd history, laboratory results, and statistical analyses using univariate tests and multivariable binary logistic regression. Key findings revealed significant associations with abortion, including previous abortion history, gestational age of the aborted foetus, routine veterinary visits, mineral supplementation, and vaccination practices. Non-infectious factors, such as pregnancy toxemia, goiter, and deficiencies in vitamin E/selenium, were identified in herds with a low abortion prevalence (<10 %). Among the 623 herds studied, 277 (44.5 %) exhibited an abortion prevalence below 2 %, considered within normal limits, while the remaining 346 herds (55.5 %) experienced pathological abortion rates exceeding 2 %. The definitive cause of abortion was determined in 227 of the 346 abortion outbreaks analysed, accounting for 65.6 % of the cases. Infectious agents were identified in 40.7 % of the herds with abortion rates exceeding 2 %, with <em>Brucella melitensis</em> (9.5 %), <em>Chlamydia abortus</em> (7.8 %), and <em>Coxiella burnetii</em> (5.2 %) being the most prevalent pathogens. Multivariable binary logistic regression analysis revealed significant associations between abortion and several factors, including birth (OR=2.01, 95 % CI: 1.05–3.89, P=0.036), previous abortion history (OR=14.5, 95 % CI: 6.01–37.3, P<0.001), gestational age of the aborted foetus (OR=3.07, 95 % CI: 1.63–5.89, P<0.001), routine veterinary visits (OR=0.16, 95 % CI: 0.09–0.27, P<0.001), vaccination (OR=0.25, 95 % CI: 0.11–0.53, P<0.001), and mineral supplementation (OR=0.36, 95 % CI: 0.21–0.62, P<0.001). These findings underscore the diverse causes of abortion in Iranian goat herds, emphasizing the need to improve farmer awareness and access to commercial vaccines targeting infectious abortion agents to enhance herd productivity.</div></div>","PeriodicalId":20413,"journal":{"name":"Preventive veterinary medicine","volume":"234 ","pages":"Article 106381"},"PeriodicalIF":2.2,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142626517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-06DOI: 10.1016/j.prevetmed.2024.106369
Joana Ferreira-e-Silva , Saúl Jiménez-Ruiz , Marisa Rodrigues , Emídio Santos , Sabrina Castro-Scholten , Vitor Lizana , Alba Martí-Marco , Tereza Almeida , Ana M. Lopes , Joana Abrantes , Juan Bárcena , Esther Blanco , Carlos Rouco , Ignacio García-Bocanegra , Paulo Célio Alves , Nuno Santos
Myxoma (MYXV) and rabbit hemorrhagic disease (RHDV) viruses are pathogens of economic relevance for cuniculture and conservation concern for wild European rabbits (Oryctolagus cuniculus), recently classified as ‘Endangered’ in its native range. Large-scale serological surveys, facilitated by sample collection using dried blood spots (DBS), allow monitoring seroprevalence in the wild reservoir but require evaluating the technique for the host and pathogen of interest. This study aimed to evaluate Protein Saver 903 DBS for MYXV and RHDV (genotype GI.2) serological surveys in European rabbits. Paired serum and DBS collected from 172 rabbits harvested or found dead in the Iberian Peninsula were tested for IgG antibodies specific against MYXV and RHDV GI.2 using indirect ELISA. We found an almost perfect agreement between serum and DBS for MYXV (Cohen's κ=0.914, CI95 0.847 – 0.981) and a strong agreement for RHDV GI.2 (Cohen's κ=0.808, CI95=0.722 – 0.893). The diagnostic sensitivity of DBS was 95.4 % (CI95 90.3 – 97.9 %) for MYXV and 82.1 % (CI95 73.2 – 88.5 %) for RHDV GI.2. The diagnostic specificity and positive predictive value were 100 % for both pathogens. This study supports DBS as a suitable sampling strategy for serological surveys of antibodies specific to MYXV and RHDV GI.2 in European rabbits, which generally agrees with results from other hosts and pathogens where this technique was evaluated.
{"title":"Evaluation of dried blood spots for serological surveys of myxoma and rabbit hemorrhagic disease viruses in their wild reservoir","authors":"Joana Ferreira-e-Silva , Saúl Jiménez-Ruiz , Marisa Rodrigues , Emídio Santos , Sabrina Castro-Scholten , Vitor Lizana , Alba Martí-Marco , Tereza Almeida , Ana M. Lopes , Joana Abrantes , Juan Bárcena , Esther Blanco , Carlos Rouco , Ignacio García-Bocanegra , Paulo Célio Alves , Nuno Santos","doi":"10.1016/j.prevetmed.2024.106369","DOIUrl":"10.1016/j.prevetmed.2024.106369","url":null,"abstract":"<div><div>Myxoma (MYXV) and rabbit hemorrhagic disease (RHDV) viruses are pathogens of economic relevance for cuniculture and conservation concern for wild European rabbits (<em>Oryctolagus cuniculus</em>), recently classified as ‘Endangered’ in its native range. Large-scale serological surveys, facilitated by sample collection using dried blood spots (DBS), allow monitoring seroprevalence in the wild reservoir but require evaluating the technique for the host and pathogen of interest. This study aimed to evaluate Protein Saver 903 DBS for MYXV and RHDV (genotype GI.2) serological surveys in European rabbits. Paired serum and DBS collected from 172 rabbits harvested or found dead in the Iberian Peninsula were tested for IgG antibodies specific against MYXV and RHDV GI.2 using indirect ELISA. We found an almost perfect agreement between serum and DBS for MYXV (Cohen's κ=0.914, CI<sub>95</sub> 0.847 – 0.981) and a strong agreement for RHDV GI.2 (Cohen's κ=0.808, CI<sub>95</sub>=0.722 – 0.893). The diagnostic sensitivity of DBS was 95.4 % (CI<sub>95</sub> 90.3 – 97.9 %) for MYXV and 82.1 % (CI<sub>95</sub> 73.2 – 88.5 %) for RHDV GI.2. The diagnostic specificity and positive predictive value were 100 % for both pathogens. This study supports DBS as a suitable sampling strategy for serological surveys of antibodies specific to MYXV and RHDV GI.2 in European rabbits, which generally agrees with results from other hosts and pathogens where this technique was evaluated.</div></div>","PeriodicalId":20413,"journal":{"name":"Preventive veterinary medicine","volume":"234 ","pages":"Article 106369"},"PeriodicalIF":2.2,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142626482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-05DOI: 10.1016/j.prevetmed.2024.106368
Paulo Gomes do Nascimento Corrêa , Pedro Ferreira de Sousa Júnior , Francisco Alyson Silva Oliveira , Glenda Lídice de Oliveira Cortez Marinho , David Germano Gonçalves Schwarz
Brazil is the fourth largest producer and exporter of pork in the world, standing out for its potential to increase pig production nationwide. Among the diseases that can severely compromise trade relations and cause significant losses in pig production in Brazil, Classical Swine Fever (CSF) is notable for being a highly contagious viral disease with high potential for spreading among domestic and wild pigs, wild boars, and peccaries. The present study aimed to identify high-risk regions for CSF in Brazil through spatial, temporal, and spatiotemporal analyses from 2000 to 2023. During this period, 3189 cases of CSF were detected, all reported exclusively in states within the CSF non-free zone. The Northeast region accounted for 90.31 % (2880/3189) of the total CSF cases, with Ceará reporting the highest number of cases at 1475 (46.25 %), of which 810 were reported in 2018 alone. The North region accounted for 9.69 % (309/3189) of the total cases, with the states of Pará and Amapá being the only ones to report cases of the disease. Temporal trend analysis identified an increase in Piauí (Annual Percentage Change [APC]: 25.58 %), Alagoas (APC: 28.01 %), and Ceará (APC: 17.99 %), a decreasing trend for Pernambuco (APC: 24.49 %), Paraíba (APC: 19.35 %), and Rio Grande do Norte (APC: 11.85 %), and stability in Maranhão (APC: 0.17 %), Pará (APC: 1.61 %), and Amapá (APC: 15.52 %). The spatiotemporal analysis identified the formation of two high-risk clusters: the primary cluster occurred in the Northeast region, specifically in the states of Ceará, Piauí, Rio Grande do Norte, Paraíba, Pernambuco, and Alagoas, between 2018 and 2019, with a total of 1556 CSF cases and Relative Risk (RRs) of 120.02. The secondary cluster was formed by the states of Rondônia, Acre, Amazônia, Roraima, Pará, Amapá, and Mato Grosso, located in the North and part of the Midwest region, for the year 2009, with a total of 309 cases and an RRs of 29.89. In conclusion, the Northeast region is considered high-risk for the emergence of new CSF cases, highlighting the states of Ceará and Piauí, which can be considered important sources of CSF virus spread to other Brazilian states, alerting authorities to the need for disease control actions.
{"title":"Geographic risk of classical swine fever in non-free regions in Brazil","authors":"Paulo Gomes do Nascimento Corrêa , Pedro Ferreira de Sousa Júnior , Francisco Alyson Silva Oliveira , Glenda Lídice de Oliveira Cortez Marinho , David Germano Gonçalves Schwarz","doi":"10.1016/j.prevetmed.2024.106368","DOIUrl":"10.1016/j.prevetmed.2024.106368","url":null,"abstract":"<div><div>Brazil is the fourth largest producer and exporter of pork in the world, standing out for its potential to increase pig production nationwide. Among the diseases that can severely compromise trade relations and cause significant losses in pig production in Brazil, Classical Swine Fever (CSF) is notable for being a highly contagious viral disease with high potential for spreading among domestic and wild pigs, wild boars, and peccaries. The present study aimed to identify high-risk regions for CSF in Brazil through spatial, temporal, and spatiotemporal analyses from 2000 to 2023. During this period, 3189 cases of CSF were detected, all reported exclusively in states within the CSF non-free zone. The Northeast region accounted for 90.31 % (2880/3189) of the total CSF cases, with Ceará reporting the highest number of cases at 1475 (46.25 %), of which 810 were reported in 2018 alone. The North region accounted for 9.69 % (309/3189) of the total cases, with the states of Pará and Amapá being the only ones to report cases of the disease. Temporal trend analysis identified an increase in Piauí (Annual Percentage Change [APC]: 25.58 %), Alagoas (APC: 28.01 %), and Ceará (APC: 17.99 %), a decreasing trend for Pernambuco (APC: 24.49 %), Paraíba (APC: 19.35 %), and Rio Grande do Norte (APC: 11.85 %), and stability in Maranhão (APC: 0.17 %), Pará (APC: 1.61 %), and Amapá (APC: 15.52 %). The spatiotemporal analysis identified the formation of two high-risk clusters: the primary cluster occurred in the Northeast region, specifically in the states of Ceará, Piauí, Rio Grande do Norte, Paraíba, Pernambuco, and Alagoas, between 2018 and 2019, with a total of 1556 CSF cases and Relative Risk (RRs) of 120.02. The secondary cluster was formed by the states of Rondônia, Acre, Amazônia, Roraima, Pará, Amapá, and Mato Grosso, located in the North and part of the Midwest region, for the year 2009, with a total of 309 cases and an RRs of 29.89. In conclusion, the Northeast region is considered high-risk for the emergence of new CSF cases, highlighting the states of Ceará and Piauí, which can be considered important sources of CSF virus spread to other Brazilian states, alerting authorities to the need for disease control actions.</div></div>","PeriodicalId":20413,"journal":{"name":"Preventive veterinary medicine","volume":"234 ","pages":"Article 106368"},"PeriodicalIF":2.2,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142626483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-05DOI: 10.1016/j.prevetmed.2024.106370
Tara Prezioso , Alicia Boakes , Jeff Wrathall , W. Jonas Reger , Suman Bhowmick , Rebecca Lee Smith
Introduction
The U.S. swine industry is vulnerable to the rapid spread of disease due to systemic structural issues. While animal movement networks are used to identify disease spread risks and design response plans, human movement between farms were rarely accounted for. Human movements, when integrated with animal movement models, create a different, more inclusive, and accurate network structure when compared to animal movements alone.
Methods
One year of propriety farm visit data was analyzed and consisted of anonymized property IDs, location, and user/truck IDs, along with visit dates, property, vehicle, and entry types from three swine management companies. A static directed network was created using the igraph package in R for all movements, with separate sub-networks for each entry type (animal, human, and subsets of vehicle types). Network statistics for each sub-network were compared.
Results
The full network included 455 properties, 11 property types, 9 vehicle types, 12 entry types, and 320001 edges (trips between properties). The longest path length was 10 in the animal movement network but decreased to 5 for the full and human movement network, while the average path length decreased from 3.2 to 2.2. Edge density increased from 0.03 to 0.09 for the human network and 0.1 for the full network. For all network properties examined, the full and human movement networks demonstrated higher connectivity than the animal network. A heavy right skew in the degree distributions indicates a 'hub' structure (scale-free-like network) and the shorter path lengths indicates a small-world network topology.
Discussion
The full network is very well connected, more so than expected based on animal movement alone. Hubs may indicate points of disease susceptibility and 'super-spreader' properties. The high connectivity shows that swine farm networks may be more susceptible to spread of an introduced disease than expected from previous analyses.
Conclusions
Monitoring human, as well as animal movement, provides for a more complete and accurate understanding of swine farm biosecurity risks.
{"title":"A network evaluation of human and animal movement data across multiple swine farm systems in North America","authors":"Tara Prezioso , Alicia Boakes , Jeff Wrathall , W. Jonas Reger , Suman Bhowmick , Rebecca Lee Smith","doi":"10.1016/j.prevetmed.2024.106370","DOIUrl":"10.1016/j.prevetmed.2024.106370","url":null,"abstract":"<div><h3>Introduction</h3><div>The U.S. swine industry is vulnerable to the rapid spread of disease due to systemic structural issues. While animal movement networks are used to identify disease spread risks and design response plans, human movement between farms were rarely accounted for. Human movements, when integrated with animal movement models, create a different, more inclusive, and accurate network structure when compared to animal movements alone.</div></div><div><h3>Methods</h3><div>One year of propriety farm visit data was analyzed and consisted of anonymized property IDs, location, and user/truck IDs, along with visit dates, property, vehicle, and entry types from three swine management companies. A static directed network was created using the igraph package in R for all movements, with separate sub-networks for each entry type (animal, human, and subsets of vehicle types). Network statistics for each sub-network were compared.</div></div><div><h3>Results</h3><div>The full network included 455 properties, 11 property types, 9 vehicle types, 12 entry types, and 320001 edges (trips between properties). The longest path length was 10 in the animal movement network but decreased to 5 for the full and human movement network, while the average path length decreased from 3.2 to 2.2. Edge density increased from 0.03 to 0.09 for the human network and 0.1 for the full network. For all network properties examined, the full and human movement networks demonstrated higher connectivity than the animal network. A heavy right skew in the degree distributions indicates a 'hub' structure (scale-free-like network) and the shorter path lengths indicates a small-world network topology.</div></div><div><h3>Discussion</h3><div>The full network is very well connected, more so than expected based on animal movement alone. Hubs may indicate points of disease susceptibility and 'super-spreader' properties. The high connectivity shows that swine farm networks may be more susceptible to spread of an introduced disease than expected from previous analyses.</div></div><div><h3>Conclusions</h3><div>Monitoring human, as well as animal movement, provides for a more complete and accurate understanding of swine farm biosecurity risks.</div></div>","PeriodicalId":20413,"journal":{"name":"Preventive veterinary medicine","volume":"234 ","pages":"Article 106370"},"PeriodicalIF":2.2,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142626513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bovine herpesvirus 1 (BoHV-1) is the infectious agent that causes infectious bovine rhinotracheitis (IBR), a disease affecting the reproductive and respiratory systems of cattle. Significant economic losses result from infectious bovine rhinotracheitis because of metritis, abortions, placenta retention, recurrent breeding, animal deaths, and losses from trade restrictions. Reports of the diseases have been made in southern, southwestern and in major cities that kept improved breed of dairy cows in Ethiopia with prevalence ranging from 28.5–67 %. However, there is insufficient information available regarding the frequency and spread of IBR in the northwest part of the nation. In northwest Ethiopia, a cross-sectional study was carried out to estimate seroprevalence of BoHV-1 and identify associated risk factors. Dairy farms and farm owners were chosen using a multistage cluster sampling technique, while dairy cattle were chosen using a simple random sample technique. Four hundred and thirty-one dairy cattle from 177 herds in the Debark and Lay-Armachiho districts in the North and Central Gondar zones, respectively, both in Northwestern Ethiopia, were selected to provide serum samples. Owners of dairy animals provided information via questionnaires. Using a competitive enzyme-linked immunosorbent assay (c-ELISA), anti-BoHV-1 antibodies were detected in serum samples. To identify risk factors, univariable and multivariable mixed effect logistic regression models were used. We calculated animal level and herd level seroprevalence of 72 % (95 % CI: 64.9–78.4 %) and 85.7 % (95 % CI: 79.8–90 %), respectively. Parity was associated with seroprevalence of BoHV-1; cows with higher parity had increased seroprevalence of BoHV-1. Bull mating [OR=3.13, (95 % CI: 1.74–5.64)] compared to AI and Debark district [OR=2.73 (95 % CI: 1.63–4.57)] compared to Lay-Armachiho district, were associated with seroprevalence of BoHV-1. The study had shown that BoHV-1 is circulating out of the major cities and also on dairy farms keeping local breeds of dairy cows in Gondar zones, North-West Ethiopia. This suggests need of attention in prevention and control of BoHV-1.
{"title":"Seroprevalence and associated risk factors of bovine herpesvirus 1 in smallholder dairy farms in two districts of Gondar zones, North-West Ethiopia","authors":"Tsegaye Asredie Kolech , Yoseph Kerie Kebede , Sefinew Alemu Mekonnen","doi":"10.1016/j.prevetmed.2024.106367","DOIUrl":"10.1016/j.prevetmed.2024.106367","url":null,"abstract":"<div><div>Bovine herpesvirus 1 (BoHV-1) is the infectious agent that causes infectious bovine rhinotracheitis (IBR), a disease affecting the reproductive and respiratory systems of cattle. Significant economic losses result from infectious bovine rhinotracheitis because of metritis, abortions, placenta retention, recurrent breeding, animal deaths, and losses from trade restrictions. Reports of the diseases have been made in southern, southwestern and in major cities that kept improved breed of dairy cows in Ethiopia with prevalence ranging from 28.5–67 %. However, there is insufficient information available regarding the frequency and spread of IBR in the northwest part of the nation. In northwest Ethiopia, a cross-sectional study was carried out to estimate seroprevalence of BoHV-1 and identify associated risk factors. Dairy farms and farm owners were chosen using a multistage cluster sampling technique, while dairy cattle were chosen using a simple random sample technique. Four hundred and thirty-one dairy cattle from 177 herds in the Debark and Lay-Armachiho districts in the North and Central Gondar zones, respectively, both in Northwestern Ethiopia, were selected to provide serum samples. Owners of dairy animals provided information via questionnaires. Using a competitive enzyme-linked immunosorbent assay (c-ELISA), anti-BoHV-1 antibodies were detected in serum samples. To identify risk factors, univariable and multivariable mixed effect logistic regression models were used. We calculated animal level and herd level seroprevalence of 72 % (95 % CI: 64.9–78.4 %) and 85.7 % (95 % CI: 79.8–90 %), respectively. Parity was associated with seroprevalence of BoHV-1; cows with higher parity had increased seroprevalence of BoHV-1. Bull mating [OR=3.13, (95 % CI: 1.74–5.64)] compared to AI and Debark district [OR=2.73 (95 % CI: 1.63–4.57)] compared to Lay-Armachiho district, were associated with seroprevalence of BoHV-1. The study had shown that BoHV-1 is circulating out of the major cities and also on dairy farms keeping local breeds of dairy cows in Gondar zones, North-West Ethiopia. This suggests need of attention in prevention and control of BoHV-1.</div></div>","PeriodicalId":20413,"journal":{"name":"Preventive veterinary medicine","volume":"234 ","pages":"Article 106367"},"PeriodicalIF":2.2,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142626555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-31DOI: 10.1016/j.prevetmed.2024.106366
Jesús Barbero-Moyano , Javier Caballero-Gómez , Moisés Gonzálvez , Remigio Martínez , Inmaculada Moreno , Eduardo Berriatua , Marta Sánchez-Sánchez , Jorge Paniagua , Isabel Fernández-Veron , María Teresa del Rey-Wamba , Elena Crespo , Juan I. Montoya-Oliver , Javier Salcedo , Maria A. Risalde , Ignacio García-Bocanegra
Leishmaniosis, caused by phlebotomine sand fly-borne Leishmania spp., is a multi-host and zoonotic disease in tropical, subtropical and temperate climates, worldwide. Leishmania infantum is the only endemic pathogenic species in Europe, and exposure to this protozoan has previously been reported in a wide range of wild mammals, including felids. However, the information about the exposure of the threatened Iberian lynx (Lynx pardinus) to L. infantum is still very scarce. Consequently, the aims of the present large-scale epidemiological study were: (1) to evaluate the circulation of L. infantum in the free-ranging and captive Iberian lynx populations and (2) to investigate potential risk factors associated with L. infantum exposure during the study period, between 2010 and 2022. A total of 783 Iberian lynxes from captive (n = 296) and free-ranging (n = 487) populations were sampled from different areas of the Iberian Peninsula. Exposure to L. infantum (positive to indirect fluorescent antibody test (IFAT) in serum and/or real-time quantitative PCR (qPCR) in spleen samples) was detected in 80 of the 783 lynxes, so the estimated prevalence (95 % confidence limits) was 10.2 % (8.1–12.3 %). Specifically, anti-Leishmania antibodies were found in 12 of the 469 lynxes (2.6 %; 1.1–4.0 %) and L. infantum kDNA was detected in 68 of the 333 lynxes (20.4 %; 16.1–24.8 %) with a Ct range from 26.0 to 38.0 (median: 36.0). One seroconversion and one seroreversion were observed among the 42 Iberian lynxes longitudinally sampled. Phylogenetic analysis revealed high homology (99.9–100 %) with other L. infantum sequences obtained from wild rabbits (Oryctolagus cuniculus), Iberian hares (Lepus granatensis) and humans from Spain. The multivariate analysis identified the habitat status (free-ranging) and age (adult and subadult) as risk factors potentially associated with L. infantum exposure in Iberian lynxes. Our results indicate moderate and widespread circulation of this pathogen in the Iberian lynx populations, suggesting its potential role as spillover hosts in Iberian Mediterranean ecosystems. Additional studies are warranted to determine the clinical impact of L. infantum exposure in this threatened species.
{"title":"Monitoring of Leishmania infantum exposure in the Iberian lynx (Lynx pardinus)","authors":"Jesús Barbero-Moyano , Javier Caballero-Gómez , Moisés Gonzálvez , Remigio Martínez , Inmaculada Moreno , Eduardo Berriatua , Marta Sánchez-Sánchez , Jorge Paniagua , Isabel Fernández-Veron , María Teresa del Rey-Wamba , Elena Crespo , Juan I. Montoya-Oliver , Javier Salcedo , Maria A. Risalde , Ignacio García-Bocanegra","doi":"10.1016/j.prevetmed.2024.106366","DOIUrl":"10.1016/j.prevetmed.2024.106366","url":null,"abstract":"<div><div>Leishmaniosis, caused by phlebotomine sand fly-borne <em>Leishmania</em> spp., is a multi-host and zoonotic disease in tropical, subtropical and temperate climates, worldwide. <em>Leishmania infantum</em> is the only endemic pathogenic species in Europe, and exposure to this protozoan has previously been reported in a wide range of wild mammals, including felids. However, the information about the exposure of the threatened Iberian lynx (<em>Lynx pardinus</em>) to <em>L. infantum</em> is still very scarce. Consequently, the aims of the present large-scale epidemiological study were: (1) to evaluate the circulation of <em>L. infantum</em> in the free-ranging and captive Iberian lynx populations and (2) to investigate potential risk factors associated with <em>L. infantum</em> exposure during the study period, between 2010 and 2022. A total of 783 Iberian lynxes from captive (n = 296) and free-ranging (n = 487) populations were sampled from different areas of the Iberian Peninsula. Exposure to <em>L. infantum</em> (positive to indirect fluorescent antibody test (IFAT) in serum and/or real-time quantitative PCR (qPCR) in spleen samples) was detected in 80 of the 783 lynxes, so the estimated prevalence (95 % confidence limits) was 10.2 % (8.1–12.3 %). Specifically, anti-<em>Leishmania</em> antibodies were found in 12 of the 469 lynxes (2.6 %; 1.1–4.0 %) and <em>L. infantum</em> kDNA was detected in 68 of the 333 lynxes (20.4 %; 16.1–24.8 %) with a Ct range from 26.0 to 38.0 (median: 36.0). One seroconversion and one seroreversion were observed among the 42 Iberian lynxes longitudinally sampled. Phylogenetic analysis revealed high homology (99.9–100 %) with other <em>L. infantum</em> sequences obtained from wild rabbits (<em>Oryctolagus cuniculus</em>), Iberian hares (<em>Lepus granatensis</em>) and humans from Spain. The multivariate analysis identified the habitat status (free-ranging) and age (adult and subadult) as risk factors potentially associated with <em>L. infantum</em> exposure in Iberian lynxes. Our results indicate moderate and widespread circulation of this pathogen in the Iberian lynx populations, suggesting its potential role as spillover hosts in Iberian Mediterranean ecosystems. Additional studies are warranted to determine the clinical impact of <em>L. infantum</em> exposure in this threatened species.</div></div>","PeriodicalId":20413,"journal":{"name":"Preventive veterinary medicine","volume":"234 ","pages":"Article 106366"},"PeriodicalIF":2.2,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142626550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-25DOI: 10.1016/j.prevetmed.2024.106364
Sebastian Davalos , Marlom Santa-Cruz , Rosario Condori , Jorge Rodriguez , J.R. Lucas
Poultry can act as a reservoir of Salmonella enterica serotype Infantis (S. Infantis) of clinical and epidemiological importance because it triggers foodborne disease outbreaks and presents antibiotic multiresistance. The present study aimed to determine antimicrobial resistance in S. Infantis isolates from poultry livers, litter and chicken carcasses from Lima, Peru, during 2022–2023. S. Infantis was isolated from 10.1 % (27/267), 4.7 % (4/86), and 8 % (2/25) of the bird, litter and carcass samples, respectively. All isolates showed resistance to nalidixic acid (NA). In addition, 94 %, 76 %, 70 %, 48 %, and 45 % of the isolates showed resistance to tetracycline (TET), amoxicillin (AMX), chloramphenicol (C), gentamicin (GEN) and trimethoprim/sulfamethoxazole (TS), respectively. All isolates showed susceptibility to imipinem and amoxicillin/clavulanic acid. Of the isolates, 93.9 % displayed multidrug resistance. The most frequent resistance pattern was C-AMX-NA-GEN-TET (24.2 %, n=8), determined even from carcass isolates, followed by C-AMX-NA-TET (18.2 %, n=6), and C-AMX-NA-GEN-TS-TET (12.1 %, n=4). The presence of these multidrug-resistant S. Infantis isolates is a threat to food safety and public health.
家禽是肠炎沙门氏菌血清型 Infantis（S. Infantis）的贮藏地，具有重要的临床和流行病学意义，因为它会引发食源性疾病暴发并产生抗生素多重耐药性。本研究旨在确定 2022-2023 年期间从秘鲁利马的家禽肝脏、粪便和鸡肉中分离出的 S. Infantis 的抗菌药耐药性。10.1 %（27/267）、4.7 %（4/86）和 8 %（2/25）的禽类、粪便和尸体样本中分别分离出了 S. Infantis。所有分离物均显示出对萘啶酸（NA）的抗药性。此外，分别有 94 %、76 %、70 %、48 % 和 45 % 的分离物对四环素（TET）、阿莫西林（AMX）、氯霉素（C）、庆大霉素（GEN）和三甲双胍/磺胺甲噁唑（TS）产生抗药性。所有分离菌株都对亚胺培南和阿莫西林/克拉维酸有敏感性。93.9% 的分离株对多种药物产生耐药性。最常见的耐药模式是 C-AMX-NA-GEN-TET（24.2%，n=8），甚至从胴体分离物中也能确定；其次是 C-AMX-NA-TET（18.2%，n=6）和 C-AMX-NA-GEN-TS-TET（12.1%，n=4）。这些耐多药的 S. Infantis 分离物的存在对食品安全和公共卫生构成威胁。
{"title":"Multiple antibiotic resistance of Salmonella Infantis in the Peruvian poultry production chain: Detection in birds, the farming environment, and chicken carcasses","authors":"Sebastian Davalos , Marlom Santa-Cruz , Rosario Condori , Jorge Rodriguez , J.R. Lucas","doi":"10.1016/j.prevetmed.2024.106364","DOIUrl":"10.1016/j.prevetmed.2024.106364","url":null,"abstract":"<div><div>Poultry can act as a reservoir of <em>Salmonella enterica</em> serotype Infantis (<em>S</em>. Infantis) of clinical and epidemiological importance because it triggers foodborne disease outbreaks and presents antibiotic multiresistance. The present study aimed to determine antimicrobial resistance in <em>S</em>. Infantis isolates from poultry livers, litter and chicken carcasses from Lima, Peru, during 2022–2023. <em>S</em>. Infantis was isolated from 10.1 % (27/267), 4.7 % (4/86), and 8 % (2/25) of the bird, litter and carcass samples, respectively. All isolates showed resistance to nalidixic acid (NA). In addition, 94 %, 76 %, 70 %, 48 %, and 45 % of the isolates showed resistance to tetracycline (TET), amoxicillin (AMX), chloramphenicol (C), gentamicin (GEN) and trimethoprim/sulfamethoxazole (TS), respectively. All isolates showed susceptibility to imipinem and amoxicillin/clavulanic acid. Of the isolates, 93.9 % displayed multidrug resistance. The most frequent resistance pattern was C-AMX-NA-GEN-TET (24.2 %, n=8), determined even from carcass isolates, followed by C-AMX-NA-TET (18.2 %, n=6), and C-AMX-NA-GEN-TS-TET (12.1 %, n=4). The presence of these multidrug-resistant <em>S</em>. Infantis isolates is a threat to food safety and public health.</div></div>","PeriodicalId":20413,"journal":{"name":"Preventive veterinary medicine","volume":"234 ","pages":"Article 106364"},"PeriodicalIF":2.2,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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