Epidemic and pandemic potential of all respiratory diseases of zoonotic origin is well known. In recent history global public health threat was inflicted by zoonotic origin infectious diseases with pandemic potential including, Ebola and Marburg haemorrhagic fevers, severe acute respiratory syndrome (SARS), influenza A (H5N1), Middle East respiratory syndrome corona virus (MERSCoV), 1 and the recently discovered COVID-19. Change of epidemic to a pandemic is just a matter of time. A novel Corona virus 2019 (COVID-19) is appearing to be one of the rapidly transmitting diseases because of the social and economic linkages worldwide. Emerging infectious diseases (EIDs) are not new but their incidence or geographical involvement is rapidly increasing. Global temporal and spatial patterns of these emerging infections are studied well in literature concluding significant correlation of EIDs with socio-economic, environmental and ecological factors. It helps to identify regions as ‘hotspots’ for EIDs with a substantial risk of vector-borne and wildlife zoonotic emerging diseases.
{"title":"Epidemic to Pandemic: Just a Matter of Time","authors":"A. Humayun, M. I. Anwar, S. Alam, U. Iqbal","doi":"10.47489/p000s344z762mc","DOIUrl":"https://doi.org/10.47489/p000s344z762mc","url":null,"abstract":"Epidemic and pandemic potential of all respiratory diseases of zoonotic origin is well known. In recent history global public health threat was inflicted by zoonotic origin infectious diseases with pandemic potential including, Ebola and Marburg haemorrhagic fevers, severe acute respiratory syndrome (SARS), influenza A (H5N1), Middle East respiratory syndrome corona virus (MERSCoV), 1 and the recently discovered COVID-19. Change of epidemic to a pandemic is just a matter of time. A novel Corona virus 2019 (COVID-19) is appearing to be one of the rapidly transmitting diseases because of the social and economic linkages worldwide. Emerging infectious diseases (EIDs) are not new but their incidence or geographical involvement is rapidly increasing. Global temporal and spatial patterns of these emerging infections are studied well in literature concluding significant correlation of EIDs with socio-economic, environmental and ecological factors. It helps to identify regions as ‘hotspots’ for EIDs with a substantial risk of vector-borne and wildlife zoonotic emerging diseases.","PeriodicalId":20500,"journal":{"name":"Proceedings of Shaikh Zayed Medical Complex Lahore","volume":"183 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72668294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-02DOI: 10.47489/p000s334z7221-4mc
W. Khan
Introduction: The frequency of QT interval prolongation as published in the international and local literature has been variable. Aims & Objectives: To determine the frequency of QT interval prolongation in patients with chronic liver disease and resolve the variability in the literature. Place and duration of study: The present study was conducted in Gastroenterology and Hepatology Unit Shaikh Zayed Hospital Lahore from 1st March 2017 to 31st August 2017. Material & Methods: About 240 patients with diagnosed chronic liver disease were selected. Electrocardiography (12 lead) was performed in all patients to look for QT interval prolongation and their mean was calculated for purpose of analysis. Results: Mean age of our patients was 53.7±11.9 and male gender was dominant (55.8%). It was noted that QT interval was prolonged in 62 patients (25.8%) while rest of the 178 patients had normal QT interval. Conclusion: QT interval prolongation is frequently observed (25.8%) in chronic liver disease patients. Therefore, every patient with chronic liver disease should be investigated for QT interval prolongation. Key words: Chronic liver disease, QT interval, Electrocardiography
{"title":"Frequency of QT Interval Prolongation in Chronic Liver Disease Patients","authors":"W. Khan","doi":"10.47489/p000s334z7221-4mc","DOIUrl":"https://doi.org/10.47489/p000s334z7221-4mc","url":null,"abstract":"Introduction: The frequency of QT interval prolongation as published in the international and local literature\u0000has been variable. Aims & Objectives: To determine the frequency of QT interval prolongation in patients\u0000with chronic liver disease and resolve the variability in the literature. Place and duration of study: The\u0000present study was conducted in Gastroenterology and Hepatology Unit Shaikh Zayed Hospital Lahore from\u00001st March 2017 to 31st August 2017. Material & Methods: About 240 patients with diagnosed chronic liver\u0000disease were selected. Electrocardiography (12 lead) was performed in all patients to look for QT interval\u0000prolongation and their mean was calculated for purpose of analysis. Results: Mean age of our patients was\u000053.7±11.9 and male gender was dominant (55.8%). It was noted that QT interval was prolonged in 62 patients\u0000(25.8%) while rest of the 178 patients had normal QT interval. Conclusion: QT interval prolongation is\u0000frequently observed (25.8%) in chronic liver disease patients. Therefore, every patient with chronic liver\u0000disease should be investigated for QT interval prolongation.\u0000Key words: Chronic liver disease, QT interval, Electrocardiography","PeriodicalId":20500,"journal":{"name":"Proceedings of Shaikh Zayed Medical Complex Lahore","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75188511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-02DOI: 10.47489/p000s334z7241-6mc
Hassan Farooq
Introduction: Rheumatoid arthritis (RA) is a debilitating disease leading to incapacitation and deformity due to side effects of anti arthritic drugs and chronic need to use these drugs, patients often switch to and prefer phytotherapy. Aims & Objectives: The present study was the histopathological evaluation of gastrohepatoprotective effect of Cassia fistula compared to naproxen in rheumatoid arthritis murine model. Place and duration of study: This three month study was conducted at the Animal House, University of Veterinary and Animal Sciences, Lahore. Material & Methods: Ninety six male rats were randomly sorted into 12 groups (n=8). CFA injection (0.2 ml) was administered in the right hind paw of all groups except Group 1 (negative control). Group 2 (positive control) and groups 3-7 (prophylactic groups) were administered orally BD on 3 consecutive days 1,2 &3, naproxen (25mg/kg), anthraquinone (250mg/kg and 500mg/kg) and methanolic (250mg/kg and 500mg/kg) extracts of Cassia fistula respectively, the first dose given 30min prior to CFA injection .Groups 8-12 (therapeutic groups) were given naproxen, anthraquinone and methanolic extracts orally BD respectively in the same doses on 3 consecutive days 9, 10 and 11. On Day 15, histopathology of stomach & liver was done. Results: Oral anthraquinone and methanolic extracts of Cassia fistula 500mg/kg vs 250mg/kg BD, in prophylactic groups normalized histology of gastric and liver tissue more as compared to the therapeutic groups and to naproxen gastrohepatic damage . Conclusion: Cassia fistula anthraquinone and methanolic extracts exhibited greater prophylactic than therapeutic, dose dependent gastrohepatoprotection as compared to naproxen damage to these organs in the CFA rheumatoid arthritis rat model. Key words: Cassia fistula, Complete Freund’s Adjuvant (CFA), naproxen, gastrohepatoprotective
简介:类风湿性关节炎(RA)是一种衰弱性疾病,由于抗关节炎药物的副作用和慢性需要使用这些药物,导致丧失能力和畸形,患者经常转向和首选植物治疗。目的:本研究比较决明子瘘与萘普生对类风湿关节炎小鼠模型胃肝保护作用的组织病理学评价。研究地点和时间:这项为期三个月的研究在拉合尔兽医和动物科学大学动物馆进行。材料与方法:雄性大鼠96只,随机分为12组(n=8)。除1组(阴性对照)外,其余各组右后爪注射CFA注射液0.2 ml。第2组(阳性对照)和第3-7组(预防组)分别于CFA注射前30min口服萘普生(25mg/kg)、蒽醌(250mg/kg、500mg/kg)、桂花提取物(250mg/kg、500mg/kg),连续第1、2、3天口服BD;第8-12组(治疗组)分别口服萘普生、蒽醌、甲醇提取物,剂量相同,连续第9、10、11天口服。第15天进行胃、肝组织病理检查。结果:口服黑曲霉蒽醌和甲醇提取物500mg/kg vs 250mg/kg BD,预防组胃和肝组织组织学正常化程度高于治疗组,且对萘普生胃肝损害的影响明显大于治疗组。结论:在CFA类风湿性关节炎大鼠模型中,与萘普生相比,黑曲霉蒽醌和甲醇提取物对这些器官的损伤具有更大的预防作用,而不是治疗作用。关键词:决明子瘘,完全弗氏佐剂,萘普生,胃肝保护
{"title":"Histopathological Evaluation of GastroHepatoprotective Effect of Cassia fistula versus\u0000Naproxen in Rat Model of Rheumatoid Arthritis","authors":"Hassan Farooq","doi":"10.47489/p000s334z7241-6mc","DOIUrl":"https://doi.org/10.47489/p000s334z7241-6mc","url":null,"abstract":"Introduction: Rheumatoid arthritis (RA) is a debilitating disease leading to incapacitation and deformity due\u0000to side effects of anti arthritic drugs and chronic need to use these drugs, patients often switch to and prefer\u0000phytotherapy. Aims & Objectives: The present study was the histopathological evaluation of gastrohepatoprotective effect of Cassia fistula compared to naproxen in rheumatoid arthritis murine model. Place\u0000and duration of study: This three month study was conducted at the Animal House, University of Veterinary\u0000and Animal Sciences, Lahore. Material & Methods: Ninety six male rats were randomly sorted into 12\u0000groups (n=8). CFA injection (0.2 ml) was administered in the right hind paw of all groups except Group 1\u0000(negative control). Group 2 (positive control) and groups 3-7 (prophylactic groups) were administered orally\u0000BD on 3 consecutive days 1,2 &3, naproxen (25mg/kg), anthraquinone (250mg/kg and 500mg/kg) and\u0000methanolic (250mg/kg and 500mg/kg) extracts of Cassia fistula respectively, the first dose given 30min prior\u0000to CFA injection .Groups 8-12 (therapeutic groups) were given naproxen, anthraquinone and methanolic\u0000extracts orally BD respectively in the same doses on 3 consecutive days 9, 10 and 11. On Day 15,\u0000histopathology of stomach & liver was done. Results: Oral anthraquinone and methanolic extracts of Cassia\u0000fistula 500mg/kg vs 250mg/kg BD, in prophylactic groups normalized histology of gastric and liver tissue\u0000more as compared to the therapeutic groups and to naproxen gastrohepatic damage . Conclusion: Cassia\u0000fistula anthraquinone and methanolic extracts exhibited greater prophylactic than therapeutic, dose dependent\u0000gastrohepatoprotection as compared to naproxen damage to these organs in the CFA rheumatoid arthritis rat\u0000model.\u0000Key words: Cassia fistula, Complete Freund’s Adjuvant (CFA), naproxen, gastrohepatoprotective","PeriodicalId":20500,"journal":{"name":"Proceedings of Shaikh Zayed Medical Complex Lahore","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89540447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}