Pub Date : 2018-08-06DOI: 10.23751/PN.V20I1-S.6062
Saeid Hadi, P. Mirmiran, Reza Daryabeygi-Khotbesara, Vahid Hadi
Objectives: Diabetes mellitus (DM) is the most common chronic disease and a challenging global health problem. Inflammation plays a key role in the pathogenesis of DM. The experimental studies have shown that Nigella sativa (N. sativa) oil extract is a potential anti-inflammatory and anti-oxidant substance. The present study was conducted to evaluate the anti-inflammatory and antioxidant effects of N. sativa among adults diagnosed with type 2 diabetes (T2D). Methods: A double-blind placebo controlled trial was designed. A total of 43 participants were assigned into either intervention (N=23) or control (N=20) conditions. The intervention group received 500 mg N. sativa capsules twice a day, while control group received identical amounts of placebo capsules twice a day for 8 weeks. Dietary intake, physical activity, anthropometric indices, and fasting blood samples were measured at baseline and one week post-intervention. Results: Findings revealed significant reductions in malondialdehyde (MDA) and nitric oxide (NO) within the intervention condition, although between-group analysis did not show any significant changes neither for MAD nor NO. Besides, within- and between-group analyses did not show any significant differences pre- and post-intervention for interleukin 1β (IL-1β), tumor necrosis factor-α (TNF-α), superoxide dismutase (SOD), and catalase (CAT). Conclusions: The current study revealed favorable effects for N. sativa oil extract in reducing MDA and NO among people with T2D. However, future research is needed to establish potential anti-inflammatory and anti-oxidative responses of N. sativa in diabetes.
{"title":"Effect of Nigella sativa oil extract on inflammatory cytokine response and oxidative stress among people with type 2 diabetes mellitus: a randomized, double-blind, placebo controlled trial","authors":"Saeid Hadi, P. Mirmiran, Reza Daryabeygi-Khotbesara, Vahid Hadi","doi":"10.23751/PN.V20I1-S.6062","DOIUrl":"https://doi.org/10.23751/PN.V20I1-S.6062","url":null,"abstract":"Objectives: Diabetes mellitus (DM) is the most common chronic disease and a challenging global health problem. Inflammation plays a key role in the pathogenesis of DM. The experimental studies have shown that Nigella sativa (N. sativa) oil extract is a potential anti-inflammatory and anti-oxidant substance. The present study was conducted to evaluate the anti-inflammatory and antioxidant effects of N. sativa among adults diagnosed with type 2 diabetes (T2D). Methods: A double-blind placebo controlled trial was designed. A total of 43 participants were assigned into either intervention (N=23) or control (N=20) conditions. The intervention group received 500 mg N. sativa capsules twice a day, while control group received identical amounts of placebo capsules twice a day for 8 weeks. Dietary intake, physical activity, anthropometric indices, and fasting blood samples were measured at baseline and one week post-intervention. Results: Findings revealed significant reductions in malondialdehyde (MDA) and nitric oxide (NO) within the intervention condition, although between-group analysis did not show any significant changes neither for MAD nor NO. Besides, within- and between-group analyses did not show any significant differences pre- and post-intervention for interleukin 1β (IL-1β), tumor necrosis factor-α (TNF-α), superoxide dismutase (SOD), and catalase (CAT). Conclusions: The current study revealed favorable effects for N. sativa oil extract in reducing MDA and NO among people with T2D. However, future research is needed to establish potential anti-inflammatory and anti-oxidative responses of N. sativa in diabetes.","PeriodicalId":20600,"journal":{"name":"Progress in Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42998919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-06DOI: 10.23751/PN.V20I1-S.5543
H. Rahman, Shaikh Shahinur Rahman
Purpose: Rapeseed oil contains high percentage of erucic acid which causes cardio-hepatic toxicity. Methods: In this study, different doses of sesame oil (SO) and coconut oil (CO) were mixed with constant dose of rapeseed oil and fed to Wistar rats for 6 weeks. After the experimental period, abdomen aortic blood was collected and serum enzymes level such as CK-MB, SGOT and SGPT were measured. Results: Rapeseed oil not only increased SGPT enzyme level over control diet but also elevated CK-MB and SGOT significantly. Whereas, sesame oil and coconut oil showed protective effect against rapeseed oil induced cardio-hepatic enzymes. Moreover, higher doses of both oils represented better effect against rapeseed oil toxicity. Although CO and SO significantly decreased serum CK-MB, SGOT and SGPT activities, coconut oil had greater effect on cardiac enzymes like CK-MB while sesame oil were more significant for SGPT and SGOT. Conclusion: Therefore, the ameliorating effects of sesame oil and coconut oil trimmed down the toxic effects of rapeseed oil in rats.
{"title":"Effects of coconut oil (Cocos nucifera) and sesame oils (Sesamum indicum L.) on rapeseed powder induced changes of cardio-hepatic enzymes in Wistar rats.","authors":"H. Rahman, Shaikh Shahinur Rahman","doi":"10.23751/PN.V20I1-S.5543","DOIUrl":"https://doi.org/10.23751/PN.V20I1-S.5543","url":null,"abstract":"Purpose: Rapeseed oil contains high percentage of erucic acid which causes cardio-hepatic toxicity. Methods: In this study, different doses of sesame oil (SO) and coconut oil (CO) were mixed with constant dose of rapeseed oil and fed to Wistar rats for 6 weeks. After the experimental period, abdomen aortic blood was collected and serum enzymes level such as CK-MB, SGOT and SGPT were measured. Results: Rapeseed oil not only increased SGPT enzyme level over control diet but also elevated CK-MB and SGOT significantly. Whereas, sesame oil and coconut oil showed protective effect against rapeseed oil induced cardio-hepatic enzymes. Moreover, higher doses of both oils represented better effect against rapeseed oil toxicity. Although CO and SO significantly decreased serum CK-MB, SGOT and SGPT activities, coconut oil had greater effect on cardiac enzymes like CK-MB while sesame oil were more significant for SGPT and SGOT. Conclusion: Therefore, the ameliorating effects of sesame oil and coconut oil trimmed down the toxic effects of rapeseed oil in rats.","PeriodicalId":20600,"journal":{"name":"Progress in Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43035983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-06DOI: 10.23751/PN.V20I1-S.5854
Masoumeh Atefi, G. Pishdad, S. Faghih
Objective: A number of studies indicated that olive oil (OO) and canola oil (CO) have lipid-lowering and blood pressure-lowering effects. This clinical trial was done to compare the effects of CO and OO on serum lipids and blood pressure in women with type 2 diabetes. Methods: This randomized controlled clinical trial was done on 77 type 2 diabetic women. 4 weeks before the intervention, lipid-lowering drugs intakes were cut under the supervision of an endocrinologist. The participants were randomly allocated into 2 intervention groups (Balanced diet + 30 grams/day OO or CO) and one control group (Balanced diet + 30 grams/day of sunflower oil (SFO)). Dietary intakes were assessed using three 24-hour food records at baseline and at weeks 4 and 8 of the interventions. At baseline and after 8 weeks, height, weight, waist circumference, systolic blood pressure (SBP), diastolic blood pressure (DBP), serum total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein (VLDL-C) and high-density lipoprotein cholesterol (HDL-C) were measured and the data were statistically analyzed by SPSS 19. Results: After treatment, SBP (p=0.02), TG (p=0.01) and VLDL-C (p=0.02) were significantly decreased in OO group. None of the variables had significant changes in CO or SFO groups. There were no significant differences in the blood pressure and lipid profile among 3 groups. Conclusion: Although we found no differences between the effects of CO, OO, and SFO, it seems that replacing CO and SFO by OO may have some beneficial effects on SBP, TG and VLDL-C in women with type 2 diabetes.
{"title":"Canola oil and olive oil impact on lipid profile and blood pressure in women with type 2 diabetes: a randomized, controlled trial","authors":"Masoumeh Atefi, G. Pishdad, S. Faghih","doi":"10.23751/PN.V20I1-S.5854","DOIUrl":"https://doi.org/10.23751/PN.V20I1-S.5854","url":null,"abstract":"Objective: A number of studies indicated that olive oil (OO) and canola oil (CO) have lipid-lowering and blood pressure-lowering effects. This clinical trial was done to compare the effects of CO and OO on serum lipids and blood pressure in women with type 2 diabetes. Methods: This randomized controlled clinical trial was done on 77 type 2 diabetic women. 4 weeks before the intervention, lipid-lowering drugs intakes were cut under the supervision of an endocrinologist. The participants were randomly allocated into 2 intervention groups (Balanced diet + 30 grams/day OO or CO) and one control group (Balanced diet + 30 grams/day of sunflower oil (SFO)). Dietary intakes were assessed using three 24-hour food records at baseline and at weeks 4 and 8 of the interventions. At baseline and after 8 weeks, height, weight, waist circumference, systolic blood pressure (SBP), diastolic blood pressure (DBP), serum total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein (VLDL-C) and high-density lipoprotein cholesterol (HDL-C) were measured and the data were statistically analyzed by SPSS 19. Results: After treatment, SBP (p=0.02), TG (p=0.01) and VLDL-C (p=0.02) were significantly decreased in OO group. None of the variables had significant changes in CO or SFO groups. There were no significant differences in the blood pressure and lipid profile among 3 groups. Conclusion: Although we found no differences between the effects of CO, OO, and SFO, it seems that replacing CO and SFO by OO may have some beneficial effects on SBP, TG and VLDL-C in women with type 2 diabetes.","PeriodicalId":20600,"journal":{"name":"Progress in Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46919976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-06DOI: 10.23751/PN.V20I1-S.5576
F. A. Özdemir, N. Gur
Apricot (Prunus armeniaca L.) is highly nutritious fruit and micro propagation of apricot plant has high economic value. The current study reports micro propagation of cultivar Cataloglu using apical node explants on Murashige and Skoog (MS) medium containing different combinations of BAP+NAA supplemented with 3% sucrose and solidified with 0.65% agar. The results showed a significant effect of concentrations of BAP+NAA on callus induction, shoot regeneration and their length. Rooting percentage was not affected on all shoots regenerated on any concentration of BAP+NAA. However, number of roots per explants and their length had clear implications of the concentrations of BAP+NAA used for regenerating shoots. Optimum shoot regeneration was noted on MS medium containing 1 mg/l BAP + 0.25 mg/l NAA; which were rooted on MS medium containing 1 mg/l IBA. The rooted plantlets were acclimatized in pots containing soil:sand (3:1) ratio under greenhouse conditions. It is concluded that the study will serve as reference for future apricot breeding studies and genetic transformation studies.
{"title":"In vitro propagation of Cataloglu Apricot (Prunus armeniaca L.) cultivar using apical node as explant","authors":"F. A. Özdemir, N. Gur","doi":"10.23751/PN.V20I1-S.5576","DOIUrl":"https://doi.org/10.23751/PN.V20I1-S.5576","url":null,"abstract":"Apricot (Prunus armeniaca L.) is highly nutritious fruit and micro propagation of apricot plant has high economic value. The current study reports micro propagation of cultivar Cataloglu using apical node explants on Murashige and Skoog (MS) medium containing different combinations of BAP+NAA supplemented with 3% sucrose and solidified with 0.65% agar. The results showed a significant effect of concentrations of BAP+NAA on callus induction, shoot regeneration and their length. Rooting percentage was not affected on all shoots regenerated on any concentration of BAP+NAA. However, number of roots per explants and their length had clear implications of the concentrations of BAP+NAA used for regenerating shoots. Optimum shoot regeneration was noted on MS medium containing 1 mg/l BAP + 0.25 mg/l NAA; which were rooted on MS medium containing 1 mg/l IBA. The rooted plantlets were acclimatized in pots containing soil:sand (3:1) ratio under greenhouse conditions. It is concluded that the study will serve as reference for future apricot breeding studies and genetic transformation studies.","PeriodicalId":20600,"journal":{"name":"Progress in Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46373284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-06DOI: 10.23751/PN.V20I1-S.5961
R. Abdullah, M. Zulfiqar, Z. Akram, M. Iqtedar, A. Kaleem, S. Naz
Chickpea is one of the highly nutritious pulses. It is a rich source of proteins and carbohydrates, providing dietary as well as health benefits too. Pakistan is the 3rd major producer, of chickpea but due to post harvest losses (insect and microbial infestation) huge quantity of Desi chick pea goes to waste. In the present study, the research was directed to increase the shelf life by reducing post-harvest losses of Desi chickpea using gamma radiations. The Desi chick pea were irradiated at different gamma radiation doses (0.5, 1, 2 kGy). Sensory analysis, insect infestation, proximate and microbial analysis were carried out after every 20 days interval for all the treatments. A remarkable reduction in microflora and insect infestation was occurred at 2kGy as compared to control samples stored at ambient temperature without affecting the sensory properties. The variation in proximate composition with gamma radiation treatment was not significant with increase in dose. Sample irradiated at 2kGy showed one month shelf life enhancement as compared to control.
{"title":"Influence of gamma irradiation on microflora, sensory quality, nutritional properties and shelf life of Desi chickpea (Cicer arietinum)","authors":"R. Abdullah, M. Zulfiqar, Z. Akram, M. Iqtedar, A. Kaleem, S. Naz","doi":"10.23751/PN.V20I1-S.5961","DOIUrl":"https://doi.org/10.23751/PN.V20I1-S.5961","url":null,"abstract":"Chickpea is one of the highly nutritious pulses. It is a rich source of proteins and carbohydrates, providing dietary as well as health benefits too. Pakistan is the 3rd major producer, of chickpea but due to post harvest losses (insect and microbial infestation) huge quantity of Desi chick pea goes to waste. In the present study, the research was directed to increase the shelf life by reducing post-harvest losses of Desi chickpea using gamma radiations. The Desi chick pea were irradiated at different gamma radiation doses (0.5, 1, 2 kGy). Sensory analysis, insect infestation, proximate and microbial analysis were carried out after every 20 days interval for all the treatments. A remarkable reduction in microflora and insect infestation was occurred at 2kGy as compared to control samples stored at ambient temperature without affecting the sensory properties. The variation in proximate composition with gamma radiation treatment was not significant with increase in dose. Sample irradiated at 2kGy showed one month shelf life enhancement as compared to control.","PeriodicalId":20600,"journal":{"name":"Progress in Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49129084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-06DOI: 10.23751/PN.V20I1-S.5415
R. Perveen, Masood Sadiq, H. A. Sakandar
Buffalo milk was fortified with different sources of calcium (Ca) and phosphorous (P) to manufacture of cheddar cheese. It was fortified with calcium chloride (CaCl2) and trisodium phosphate (Na3PO4) at level of 10 (T1), 20 (T2) and 30 (T3) mM/ milk. All samples of cheddar cheese (0, 15 and 30 days) were analyzed for moisture, fat, mineral profile such as calcium, sodium, phosphorous and potassium, sensory analysis (hand firmness, chew down degree of breakdown and chew down smoothness). The fat content of Ca and P enriched cheeses exhibited significant differences due to treatments (23.87±0.63to 23.13±0.56%). No obvious significantly effects were observed in moisture fat, mineral profile, ash and organoleptic characteristics on cheddar cheeses during ripening. The salt fortified cheese showed significant effect of mineral with treatments; sodium (612.52±4.17 to 634.47±7.68 mg/100g), potassium (64.76±2.21 to 74.04±2.02mg/100g), calcium (831.58±4.55 to 874.45±2.62mg/100g). Additionally, hedonic response of developed cheeses was significantly affected due to treatments. Decisively, colloidal supramolecular structures of caseins in buffalo milk play a pivotal role in cheese making and other related organoleptic characteristics. Thus, buffalo milk casein along with calcium and phosphorus incorporation for the development of novel cheese formulation is a pragmatic approach in the field of dairy technology.
{"title":"Sensory attributes of mineral fortified low fat buffalo milk Cheddar cheese","authors":"R. Perveen, Masood Sadiq, H. A. Sakandar","doi":"10.23751/PN.V20I1-S.5415","DOIUrl":"https://doi.org/10.23751/PN.V20I1-S.5415","url":null,"abstract":"Buffalo milk was fortified with different sources of calcium (Ca) and phosphorous (P) to manufacture of cheddar cheese. It was fortified with calcium chloride (CaCl2) and trisodium phosphate (Na3PO4) at level of 10 (T1), 20 (T2) and 30 (T3) mM/ milk. All samples of cheddar cheese (0, 15 and 30 days) were analyzed for moisture, fat, mineral profile such as calcium, sodium, phosphorous and potassium, sensory analysis (hand firmness, chew down degree of breakdown and chew down smoothness). The fat content of Ca and P enriched cheeses exhibited significant differences due to treatments (23.87±0.63to 23.13±0.56%). No obvious significantly effects were observed in moisture fat, mineral profile, ash and organoleptic characteristics on cheddar cheeses during ripening. The salt fortified cheese showed significant effect of mineral with treatments; sodium (612.52±4.17 to 634.47±7.68 mg/100g), potassium (64.76±2.21 to 74.04±2.02mg/100g), calcium (831.58±4.55 to 874.45±2.62mg/100g). Additionally, hedonic response of developed cheeses was significantly affected due to treatments. Decisively, colloidal supramolecular structures of caseins in buffalo milk play a pivotal role in cheese making and other related organoleptic characteristics. Thus, buffalo milk casein along with calcium and phosphorus incorporation for the development of novel cheese formulation is a pragmatic approach in the field of dairy technology.","PeriodicalId":20600,"journal":{"name":"Progress in Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45948546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-06DOI: 10.23751/PN.V20I1-S.6078
M. Zilaee, M. Soukhtanloo, M. Ghayour-Mobarhan, Maryam Shemshian, M. Salehi, G. Ferns
Background: Metabolic syndrome is a risk factor for cardiovascular disease and diabetes mellitus. A decreased level of serum leptin is reported for obese populations. Beneficial effects of saffron on human health, including appetite-regulation, have been reported previously. The aim of this study was to investigating the effect of saffron supplementation on serum leptin levels in patients with metabolic syndrome. Material and method: Patients with metabolic syndrome were randomly divided into two groups; a case group, receiving saffron and a control group, receiving placebo. Concentration of serum leptin was measured at baseline and after 12 weeks of the start of study. SPSS software was used to analyze the data. Results: There was a borderline (p=0.05) significant difference in serum leptin before and after treatment with saffron, but not in the placebo group. There was a significant difference in serum leptin concentrations between the groups (p=0.001). Conclusion: Saffron supplementation has no significant effect on serum leptin levels in patients with metabolic syndrome.
{"title":"Effect of saffron on serum leptin levels in patients with metabolic syndrome, a double-blind, randomized and placebo-controlled trial study","authors":"M. Zilaee, M. Soukhtanloo, M. Ghayour-Mobarhan, Maryam Shemshian, M. Salehi, G. Ferns","doi":"10.23751/PN.V20I1-S.6078","DOIUrl":"https://doi.org/10.23751/PN.V20I1-S.6078","url":null,"abstract":"Background: Metabolic syndrome is a risk factor for cardiovascular disease and diabetes mellitus. A decreased level of serum leptin is reported for obese populations. Beneficial effects of saffron on human health, including appetite-regulation, have been reported previously. The aim of this study was to investigating the effect of saffron supplementation on serum leptin levels in patients with metabolic syndrome. Material and method: Patients with metabolic syndrome were randomly divided into two groups; a case group, receiving saffron and a control group, receiving placebo. Concentration of serum leptin was measured at baseline and after 12 weeks of the start of study. SPSS software was used to analyze the data. Results: There was a borderline (p=0.05) significant difference in serum leptin before and after treatment with saffron, but not in the placebo group. There was a significant difference in serum leptin concentrations between the groups (p=0.001). Conclusion: Saffron supplementation has no significant effect on serum leptin levels in patients with metabolic syndrome.","PeriodicalId":20600,"journal":{"name":"Progress in Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46176606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-06DOI: 10.23751/PN.V20I1-S.5884
F. Kaseb, Zeinab Yazdanpanah, Akram Naghdipour Biregani, Nahid Yazdi, Z. Yazdanpanah
Introduction: Chamomile is one of the medicinal herbs, frequently used in traditional medicine for treatment of diabetes. Therefore this study aimed to evaluate the effects of chamomile herbal tea on glycemic index, lipid profile and kidney function in type 2 diabetic patients. Methods: This randomized clinical trial was conducted on 50 diabetic patients. The intervention group received standard treatment with orally 200 ml/day of chamomile infusion (10 g/100 mL boiling water) twice a day before meals (lunch and dinner) for 4 weeks. The control group only received standard therapy. Results: Consumption of the chamomile infusion was accompanied by a significant reduction in total cholesterol (TC) (p= 0.02), low density lipoprotein cholesterol (LDL-C) (p= 0.04) and creatinine (Cr) (p= 0.03). Within-group comparisons showed there was a significant decrease in fasting blood sugar and 2-h postprandial glucose in the intervention group (p= 0.01), (p= 0.03), respectively. Conclusions: Chamomile has potential desirable effects on serum levels of TC, LDL-C and Cr in patients with type 2 diabetes taking oral hypoglycemic agent.
{"title":"The effect of chamomile (Matricaria recutita L.) infusion on blood glucose, lipid profile and kidney function in type 2 diabetic patients: a randomized clinical trial","authors":"F. Kaseb, Zeinab Yazdanpanah, Akram Naghdipour Biregani, Nahid Yazdi, Z. Yazdanpanah","doi":"10.23751/PN.V20I1-S.5884","DOIUrl":"https://doi.org/10.23751/PN.V20I1-S.5884","url":null,"abstract":"Introduction: Chamomile is one of the medicinal herbs, frequently used in traditional medicine for treatment of diabetes. Therefore this study aimed to evaluate the effects of chamomile herbal tea on glycemic index, lipid profile and kidney function in type 2 diabetic patients. Methods: This randomized clinical trial was conducted on 50 diabetic patients. The intervention group received standard treatment with orally 200 ml/day of chamomile infusion (10 g/100 mL boiling water) twice a day before meals (lunch and dinner) for 4 weeks. The control group only received standard therapy. Results: Consumption of the chamomile infusion was accompanied by a significant reduction in total cholesterol (TC) (p= 0.02), low density lipoprotein cholesterol (LDL-C) (p= 0.04) and creatinine (Cr) (p= 0.03). Within-group comparisons showed there was a significant decrease in fasting blood sugar and 2-h postprandial glucose in the intervention group (p= 0.01), (p= 0.03), respectively. Conclusions: Chamomile has potential desirable effects on serum levels of TC, LDL-C and Cr in patients with type 2 diabetes taking oral hypoglycemic agent.","PeriodicalId":20600,"journal":{"name":"Progress in Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47015996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-02DOI: 10.23751/PN.V20I1-S.5507
Jian-ting Huang, Yali Shi, Minjun Sun
Grifola frondosa polysaccharide (GFP) is the extract of Grifola frondosa. In this study, 50 male wistar rats were separated into S + C, S + T, LG + T, MG + T and HG + T groups to study the effect of GFP on the immune function of heavy load exercising rats. In S + T group, blood neutrophil number, neutrophil phagocytic index and bactericidal capacity decreased significantly, and adhesion function showed remarkable increase after 8 weeks excessive exercise. Low, medium and high doses of GFP were administered to different groups based on gavage. After gavaging GFP during the eight weeks of excessive exercise, blood neutrophils in the MG + T group and HG + T group were 15.3% and 7.9% higher than in the S + T group. The blood neutrophil phagocytic indices in the MG + T and HG + T groups increased to 1.19 and 1.20, respectively, from 1.02 in the S + T group. The neutrophil bactericidal ability of blood cells in the MG + T and HG + T groups was also observed to be 46.6% and 45.6%, respectively, in comparison with 39.7% for S + T and 39.2% for LG + T group. Blood neutrophil adhesion function in the MG + T and HG + T groups was 57.4% and 57.6%, respectively. This is significantly lower than 65.6% in the S+T group. We demonstrate that feeding a medium or high dose of GFP can improve the neutrophil immune function of excessively exercising rats. A medium dose of GFP shows the most significant effect.
{"title":"Grifola Frondosa Polysaccharide (GFP) improves neutrophils immune function of heavy load exercising rats","authors":"Jian-ting Huang, Yali Shi, Minjun Sun","doi":"10.23751/PN.V20I1-S.5507","DOIUrl":"https://doi.org/10.23751/PN.V20I1-S.5507","url":null,"abstract":"Grifola frondosa polysaccharide (GFP) is the extract of Grifola frondosa. In this study, 50 male wistar rats were separated into S + C, S + T, LG + T, MG + T and HG + T groups to study the effect of GFP on the immune function of heavy load exercising rats. In S + T group, blood neutrophil number, neutrophil phagocytic index and bactericidal capacity decreased significantly, and adhesion function showed remarkable increase after 8 weeks excessive exercise. Low, medium and high doses of GFP were administered to different groups based on gavage. After gavaging GFP during the eight weeks of excessive exercise, blood neutrophils in the MG + T group and HG + T group were 15.3% and 7.9% higher than in the S + T group. The blood neutrophil phagocytic indices in the MG + T and HG + T groups increased to 1.19 and 1.20, respectively, from 1.02 in the S + T group. The neutrophil bactericidal ability of blood cells in the MG + T and HG + T groups was also observed to be 46.6% and 45.6%, respectively, in comparison with 39.7% for S + T and 39.2% for LG + T group. Blood neutrophil adhesion function in the MG + T and HG + T groups was 57.4% and 57.6%, respectively. This is significantly lower than 65.6% in the S+T group. We demonstrate that feeding a medium or high dose of GFP can improve the neutrophil immune function of excessively exercising rats. A medium dose of GFP shows the most significant effect.","PeriodicalId":20600,"journal":{"name":"Progress in Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48572559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2018-08-02DOI: 10.23751/PN.V20I1-S.5237
S. Yun, JoonHo Lee, H. Suh, E. Jung
In this study, we investigated whether the body fat suppressive effects of Cornus walteri extract (CE) were due to alterations in lipid-regulating enzyme activities in high fat diet-induced obese rats. Male Sprague-Dawley rats were randomly divided into three groups (n=6): a normal diet group (N-control), a high fat diet group (F-control), and a high fat diet group, treated orally with CE (0.25%) in their drinking water (Treatment). After five weeks, CE supplementation tended to reduce body-weight gain and visceral fat in the diet-induced obese rats. The activity of hepatic glucose-6-phosphate dehydrogenase (G6PD) and malic enzyme (ME), responsible for fatty acid synthesis, tended to be lower in the Treatment group compared to the non-treated groups. This finding indicates that the body fat suppressive effects of CE are most likely due to decreases in hepatic fatty acid synthesis. CE supplementation increased hepatic carnitine palmitoyltransferase (CPT) activity, which suggests that β-oxidation was enhanced. In conclusion, CE supplementation suppressed body fat accumulation by attenuating fatty acid synthesis and enhancing β-oxidation through alteration of lipid-regulating enzyme activities.
{"title":"Effects of Cornus walteri extract on hepatic lipid-regulating enzyme activities in high fat diet-induced obese rats","authors":"S. Yun, JoonHo Lee, H. Suh, E. Jung","doi":"10.23751/PN.V20I1-S.5237","DOIUrl":"https://doi.org/10.23751/PN.V20I1-S.5237","url":null,"abstract":"In this study, we investigated whether the body fat suppressive effects of Cornus walteri extract (CE) were due to alterations in lipid-regulating enzyme activities in high fat diet-induced obese rats. Male Sprague-Dawley rats were randomly divided into three groups (n=6): a normal diet group (N-control), a high fat diet group (F-control), and a high fat diet group, treated orally with CE (0.25%) in their drinking water (Treatment). After five weeks, CE supplementation tended to reduce body-weight gain and visceral fat in the diet-induced obese rats. The activity of hepatic glucose-6-phosphate dehydrogenase (G6PD) and malic enzyme (ME), responsible for fatty acid synthesis, tended to be lower in the Treatment group compared to the non-treated groups. This finding indicates that the body fat suppressive effects of CE are most likely due to decreases in hepatic fatty acid synthesis. CE supplementation increased hepatic carnitine palmitoyltransferase (CPT) activity, which suggests that β-oxidation was enhanced. In conclusion, CE supplementation suppressed body fat accumulation by attenuating fatty acid synthesis and enhancing β-oxidation through alteration of lipid-regulating enzyme activities.","PeriodicalId":20600,"journal":{"name":"Progress in Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47382542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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