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Climate change and human health 气候变化与人类健康
Pub Date : 2021-11-01 DOI: 10.1093/med/9780198816805.003.0014
A. Woodward, A. Macmillan
Climate change belongs in a new category of global environmental health problems. It is not just that the impacts are widely distributed: climate change is a result of unbalanced global systems. It is one of the modern threats to a ‘safe operating space’ for the planet. The effects on health occur directly, such as increased heat waves; through pressures on natural systems (reduced crop yields and undernutrition, for instance); and, as a consequence of social disruption. Also there may be impacts due to policy responses to climate change: these are so-called ‘transition risks’. Improving baseline health status is fundamental to coping with climate change, because the populations that are most seriously affected are those that already bear a heavy burden of disease. But an undifferentiated public health response is not sufficient. There are distinctive features of climate change that have to be taken into account. Mitigation, or primary prevention, will require rapid, deep cuts in greenhouse emissions if global heating is to be limited. The goal is to identify common solutions, responses to climate change that are health-enhancing rather than health damaging. There are many candidates, but by and large they are not on the path of ‘business as usual’ development.
气候变化属于全球环境卫生问题的一个新范畴。这不仅是因为影响分布广泛:气候变化是全球系统失衡的结果。这是对地球“安全运行空间”的现代威胁之一。对健康的影响直接发生,例如热浪增加;通过对自然系统施加压力(例如作物产量减少和营养不良);作为社会混乱的后果。此外,应对气候变化的政策也可能产生影响:这些就是所谓的“转型风险”。改善基线健康状况对于应对气候变化至关重要,因为受影响最严重的人群是那些已经承受沉重疾病负担的人群。但是,无差别的公共卫生应对是不够的。必须考虑到气候变化的一些显著特征。如果要限制全球变暖,减缓或初级预防将需要迅速、大幅减少温室气体排放。目标是确定共同的解决办法,应对气候变化,促进健康而不是损害健康。有很多候选人,但总的来说,他们并没有走在“一切照旧”的发展道路上。
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引用次数: 0
Tuberculosis 肺结核
Pub Date : 2021-11-01 DOI: 10.1093/med/9780198816805.003.0072
R. Rustomjee
The failure to control tuberculosis (TB) in recent times stems, at least in part, from complacency towards TB control in the 1970s and 1980s and the subsequent devastating impact of the HIV-1 pandemic, the rising emergence of drug resistance as well as the growing disparity in disease burden between developed and developing countries. Progress has also been hindered by the slow development of more effective tools such as point-of-care diagnostics and treatments for active and latent disease, preventive vaccines, and laboratory assays of disease progression, immune protection, and cure. This lack of progress is, in turn, related to a poor understanding of the fundamental relationship between Mycobacterium tuberculosis and the human host and especially the nature of what is referred to as ‘latent TB infection’. An increased focus on understanding the mechanics and drivers of transmission together with a concerted effort to translate research findings into policy and practice contextualized to local needs and resources is required. This chapter reviews recent advances in tackling tuberculosis, highlighting key unmet needs and strategies for an accelerated effort to achieve control.
近年来结核病控制的失败,至少部分是由于20世纪70年代和80年代对结核病控制的自满,以及随后艾滋病毒-1大流行的破坏性影响,耐药性的日益出现以及发达国家和发展中国家之间疾病负担的差距越来越大。更有效的工具发展缓慢也阻碍了进展,如对活动性和潜伏性疾病的即时诊断和治疗、预防性疫苗、疾病进展的实验室分析、免疫保护和治愈。这种缺乏进展反过来又与对结核分枝杆菌与人类宿主之间的基本关系,特别是对所谓的“潜伏结核感染”的性质了解不足有关。需要更加注重了解传播的机制和驱动因素,并协同努力将研究成果转化为符合当地需要和资源的政策和实践。本章回顾了防治结核病方面的最新进展,强调了尚未得到满足的关键需求和加快努力实现控制的战略。
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引用次数: 0
Occupational health 职业健康
Pub Date : 2021-11-01 DOI: 10.1093/med/9780198816805.003.0055
D. Koh, Wee Hoe Gan
Occupational health is the ‘promotion and maintenance of the highest degree of physical, mental, and social well-being of workers in all occupations’. Work-related ill-health and injuries cause considerable mortality and morbidity to workers worldwide, and are a major cause of disability, lost productivity, and sickness absence. In the occupational setting, workers may suffer from occupational diseases (those directly caused by workplace hazards); ‘work-related diseases’ (those that are multifactorial in origin with occupational exposures contributing to part of the aetiology); and non-occupational diseases that affect the general population. Primary, secondary, and tertiary preventive measures can be used to reduce the burden of disease at the workplace. Prevention of occupational ill-health requires an understanding of the work processes, the range and extent of exposures to hazards, and the steps that may be available to reduce exposure. It also requires recognition of vulnerable occupational groups such as workers in developing nations, migrant workers, child labour, women workers, and impaired workers. The standard hierarchy of control strategies for reducing exposure to workplace hazards includes elimination, substitution, isolation, engineering measures, administrative procedures, and personal protective equipment. The workplace can be a suitable venue for health promotion activities although this should not be at the expense of elimination and control of exposure to occupational hazards. As occupational health practice has evolved to consideration of health issues beyond the ‘factory gate’, the discipline now has much in common with environmental health and encompasses the philosophy and principles of good public health practice.
职业健康是"促进和保持所有职业工人的最高程度的身体、精神和社会福祉"。与工作有关的健康问题和伤害导致全世界工人的大量死亡率和发病率,并且是残疾、丧失生产力和因病缺勤的主要原因。在职业环境中,工人可能患职业病(由工作场所危害直接引起的职业病);"与工作有关的疾病"(起因是多因素的,职业接触是部分病因);以及影响普通人群的非职业疾病。可采用初级、二级和三级预防措施来减轻工作场所的疾病负担。预防职业病需要了解工作过程、接触危害的范围和程度,以及减少接触的可用步骤。它还要求承认弱势职业群体,如发展中国家的工人、移徙工人、童工、女工和残疾工人。减少工作场所危害暴露的控制策略的标准层次包括消除、替代、隔离、工程措施、行政程序和个人防护设备。工作场所可以成为促进健康活动的合适场所,但这不应以消除和控制职业危害为代价。由于职业卫生实践已发展到考虑"工厂大门"以外的健康问题,该学科现在与环境卫生有许多共同之处,并包含良好公共卫生实践的哲学和原则。
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引用次数: 0
Injury prevention and control 伤害预防与控制
Pub Date : 2021-11-01 DOI: 10.1093/med/9780198816805.003.0081
C. Peek-Asa, A. Hyder
Injuries are among the leading causes of death and disability throughout the world and contribute disproportionately to premature life lost. Injury rates are highest among middle- and low-income countries. According to analyses of the 2016 Global Burden of Disease data, injuries cause over 4.6 million deaths per year, accounting for nearly 8.4% of all deaths and 10.7% of disability-adjusted life years. Many opportunities to implement injury prevention strategies exist, and a systematic approach to injury prevention can help identify the most effective and efficient approaches. Building capacity for injury prevention activities in low- and middle-income countries is an important public health priority.
伤害是全世界死亡和残疾的主要原因之一,并不成比例地导致过早死亡。受伤率在中低收入国家最高。根据对2016年全球疾病负担数据的分析,伤害每年导致460多万人死亡,占所有死亡人数的近8.4%,占残疾调整生命年的10.7%。实施伤害预防策略的机会很多,系统的伤害预防方法可以帮助确定最有效和最有效的方法。在低收入和中等收入国家开展伤害预防活动的能力建设是一项重要的公共卫生优先事项。
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引用次数: 0
Chronic obstructive pulmonary disease and asthma 慢性阻塞性肺病和哮喘
Pub Date : 2021-11-01 DOI: 10.1093/med/9780198816805.003.0061
C. Riley, J. Bon, A. Morris
Chronic obstructive pulmonary disease (COPD) and asthma are highly prevalent, non-malignant respiratory conditions that have increased dramatically in the past half century, both in high-income and low-middle-income countries. COPD is the fourth leading cause of death worldwide, and both COPD and asthma have a profound impact on quality of life for patients and their families. Tobacco smoke remains the single most important cause of COPD, but occupational and indoor exposures have increasingly been recognized as risk factors, especially among middle- and low-income individuals. Different patterns of genetic susceptibility independent of exposure result in variability of disease expression with many patients not developing clinical COPD, although they may still develop respiratory symptoms. COPD prevalence differs greatly between countries even when controlling for smoking rates. While much progress has been made in understanding biological pathways involved in asthma, the understanding of why asthma initially develops remains elusive. Although a large number of potential risk factors have been identified, none can explain the global increases in asthma prevalence observed over the last few decades. Prevalence trends between countries have also varied, with some countries continuing to experience increases in asthma rates and some rates levelling off or even declining. These trends cannot be explained by divergent epidemiological methods or population makeup alone. Asthma control, especially for severe asthmatics and for those with non-allergic phenotypes, remains a public health problem with more efficient interventions needed to encourage smoking cessation, improve air quality, and reduce allergen exposure.
慢性阻塞性肺疾病(COPD)和哮喘是高度流行的非恶性呼吸系统疾病,在过去半个世纪中,在高收入和中低收入国家都急剧增加。慢性阻塞性肺病是全球第四大死亡原因,慢性阻塞性肺病和哮喘都对患者及其家属的生活质量产生深远影响。烟草烟雾仍然是慢性阻塞性肺病最重要的单一原因,但职业和室内暴露越来越被认为是风险因素,特别是在中低收入人群中。与暴露无关的不同遗传易感性模式导致疾病表达的变异性,许多患者未发展为临床COPD,尽管他们仍可能出现呼吸道症状。即使在控制吸烟率的情况下,各国之间的慢性阻塞性肺病患病率也存在很大差异。虽然在了解哮喘的生物学途径方面取得了很大进展,但对哮喘最初发展的原因的理解仍然难以捉摸。虽然已经确定了大量潜在的危险因素,但没有一个因素可以解释过去几十年来观察到的全球哮喘患病率的增加。各国之间的流行趋势也各不相同,一些国家的哮喘发病率继续上升,而一些国家的发病率持平甚至下降。这些趋势不能仅仅用不同的流行病学方法或人口构成来解释。哮喘控制,特别是对严重哮喘患者和非过敏表型患者,仍然是一个公共卫生问题,需要更有效的干预措施来鼓励戒烟,改善空气质量,减少过敏原暴露。
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引用次数: 0
Viral alcoholic and fatty liver diseases 病毒性酒精性肝病和脂肪肝
Pub Date : 2021-11-01 DOI: 10.1093/med/9780198816805.003.0074
Ehud Zigmond, D. Shouval
Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections, alcohol, and non-alcoholic fatty liver disease (NAFLD) are major risk factors in the development of chronic liver disease (CLD), cirrhosis, and hepatocellular carcinoma (HCC). Various estimates have been proposed regarding the global prevalence of HBV and HCV carriers. According to a recent Polaris Observatory HCV Collaborators and the World Health Organization (WHO) burden estimates that 257 and 71 million people are living in the world with HBV and HCV infection, respectively, leading to an annual death from cirrhosis/liver failure and HCC of ~900,000 and ~400,000, respectively. Alcohol consumption, which is a major risk factor for CLD and HCC, is responsible for about 3.3 million deaths annually worldwide and for 5.1% of the global burden of disease as measured in disability-adjusted life years (DALYs). In recent years NAFLD and non-alcoholic steatohepatitis (NASH) associated with the metabolic syndrome, have captured the attention of hepatologists, public health experts, and the pharma industry alike. Indeed, the incidence of NAFLD and NASH and its complications including cirrhosis and HCC, is rising to epidemic proportions in the Western population, and constitute a major health problem worldwide.
乙型肝炎病毒(HBV)和丙型肝炎病毒(HCV)感染、酒精和非酒精性脂肪性肝病(NAFLD)是慢性肝病(CLD)、肝硬化和肝细胞癌(HCC)发展的主要危险因素。关于乙型肝炎病毒和丙型肝炎病毒携带者的全球流行率,已经提出了各种估计。根据北极星观测站HCV合作者和世界卫生组织(WHO)最近的负担估计,世界上分别有2.57亿人和7100万人感染HBV和HCV,导致每年死于肝硬化/肝功能衰竭和HCC的人数分别为90万人和40万人。酒精消费是慢性肝病和肝细胞癌的一个主要危险因素,在全世界每年造成约330万人死亡,按残疾调整生命年(DALYs)计算,占全球疾病负担的5.1%。近年来,NAFLD和与代谢综合征相关的非酒精性脂肪性肝炎(NASH)引起了肝病学家、公共卫生专家和制药行业的关注。事实上,NAFLD和NASH及其并发症(包括肝硬化和肝细胞癌)的发病率正在西方人口中上升到流行病的程度,并构成世界范围内的主要健康问题。
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引用次数: 0
Cross-sectional studies 横断面研究
Pub Date : 2021-11-01 DOI: 10.1093/med/9780199661756.003.0105
M. Kogevinas, L. Chatzi
This chapter will first describe the uses of cross-sectional studies in epidemiological and public health research and then discuss methodological issues concerning the design, the main biases of these studies including response rates, and how to improve participation. In recent years these studies have also incorporated the collection of biospecimens. In aetiological research, cross-sectional studies are suitable epidemiological means for studying non-fatal diseases and effects on physiological variables that do not have a clear time of onset. However, the design of cross-sectional studies makes them less appropriate than other study designs for investigating causal associations. The chapter will finally discuss issues related to the statistical analysis of cross-sectional studies. Many of these issues are also relevant to other epidemiological designs.
本章将首先描述横断面研究在流行病学和公共卫生研究中的应用,然后讨论有关设计的方法学问题,这些研究的主要偏差,包括反应率,以及如何提高参与度。近年来,这些研究也纳入了生物标本的收集。在病原学研究中,横断面研究是研究非致死性疾病和对发病时间不明确的生理变量的影响的合适的流行病学手段。然而,横断面研究的设计使得它们比其他研究设计更不适合调查因果关系。本章最后将讨论与横断面研究的统计分析有关的问题。其中许多问题也与其他流行病学设计有关。
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引用次数: 0
Private support of public health 私人对公共卫生的支持
Pub Date : 2021-11-01 DOI: 10.1093/med/9780198816805.003.0106
Q. Karim, R. Detels
Private funding of public health is well established. These additional resources have historically made a substantial contribution by focusing attention and catalysing investments to build public health capacity globally. Private investment has been pivotal in increasing access to available vaccines, treatment services, and innovations in otherwise neglected diseases that contribute to substantial morbidity and mortality rates in resource-constrained settings. The increase in public–private sector partnerships highlight emerging novel approaches to advancing global public health through innovation in research and product development and service delivery for new and re-emerging diseases. Recently a new group of billionaire philanthropists such as Mark Zuckerberg and Bill Gates, still young and giving while they are alive, have changed the character and scope of giving. However, some giving can inadvertently be associated with negative consequences for the recipients. This chapter provides an overview of the history and current practices and impact of private giving, reflects on the benefits and challenges, and suggests how private investments could more effectively contribute to address the public health challenges of the twenty-first century and beyond.
私人对公共卫生的资助已经确立。从历史上看,这些额外资源通过集中注意力和促进投资来建设全球公共卫生能力,作出了重大贡献。私人投资在增加获得现有疫苗、治疗服务和在资源有限的环境中导致大量发病率和死亡率的被忽视疾病方面的创新方面发挥了关键作用。公私部门伙伴关系的增加凸显了通过创新研究和产品开发以及为新出现和再出现的疾病提供服务来促进全球公共卫生的新方法。最近,马克·扎克伯格(Mark Zuckerberg)和比尔·盖茨(Bill Gates)等一批年轻的亿万富翁慈善家在有生之年慷慨解囊,他们改变了捐赠的性质和范围。然而,有些捐赠可能会在不经意间给接受者带来负面影响。本章概述了私人捐赠的历史和当前做法及影响,反思了其益处和挑战,并提出了私人投资如何能够更有效地为应对二十一世纪及以后的公共卫生挑战作出贡献的建议。
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引用次数: 0
Politics of public health 公共卫生政治
Pub Date : 2021-11-01 DOI: 10.1093/med/9780198816805.003.0007
Kaitlyn McBride, L. Rosenstock
The aim of public health is to improve and protect individuals and their communities, as well as promote evidence-based policy to drive decision-making across the larger health system. Researchers in academic institutions, government agencies, and the private sector provide the science to help policymakers make evidence-based health policy decisions, such as interventions to increase smoking cessation, or policies to improve access to preventive care services. In an ideal world, science (or evidence) drives policy, with politics playing a minimal or enabling role. However, this formula recognizes that public health policy is not only decided based on science (or evidence), but science itself is increasingly vulnerable to the political process, and to attacks by a wide array of players (e.g. politicians, industry leaders, and interest groups) that have vested interests to undermine scientific evidence in order to thwart the actions that would credibly follow that knowledge. Put differently, politics are key—and can be systematically analysed—in advancing or thwarting evidence-based policy.
公共卫生的目标是改善和保护个人及其社区,并促进以证据为基础的政策,以推动整个卫生系统的决策。学术机构、政府机构和私营部门的研究人员提供科学,以帮助决策者做出基于证据的卫生政策决定,例如增加戒烟的干预措施,或改善获得预防性保健服务的政策。在一个理想的世界里,科学(或证据)驱动政策,政治发挥最小的或促成的作用。然而,这一公式认识到,公共卫生政策不仅是根据科学(或证据)决定的,而且科学本身越来越容易受到政治进程的影响,也越来越容易受到各种参与者(如政治家、行业领袖和利益集团)的攻击,这些参与者拥有破坏科学证据的既得利益,以阻碍可信地遵循这些知识的行动。换句话说,在推进或阻碍基于证据的政策方面,政治是关键,也可以被系统地分析。
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引用次数: 0
Bioterrorism 生物恐怖主义
Pub Date : 2021-11-01 DOI: 10.1093/med/9780198816805.003.0076
P. Katona
History shows us that individuals have used and likely will continue to use biological agents for terrorism purposes. Bioterrorism agents can be easily disseminated, cause severe disease and high mortality rates if cases are not treated properly, and pose significant challenges for management and response. A robust public health surveillance system that includes laboratory (including routine reportable disease surveillance), syndromic, and environmental surveillance is crucial for detection of the release of a bioterrorism agent and the resulting cases. This detection can then set into motion a robust and comprehensive public health response to minimize morbidity and mortality. A large-scale bioterrorism event would be unprecedented, straining and challenging every facet of medical and public health response and would quickly become a global emergency because of both the potential risk of infection and the shock to the global economy. A robust public health and medical workforce is necessary to respond effectively and efficiently to these types of events.
历史告诉我们,个人已经并可能继续为恐怖主义目的使用生物制剂。生物恐怖主义制剂很容易传播,如果病例得不到适当治疗,会造成严重疾病和高死亡率,并对管理和应对构成重大挑战。一个强有力的公共卫生监测系统,包括实验室(包括常规报告性疾病监测)、综合征和环境监测,对于发现生物恐怖主义制剂的释放和由此产生的病例至关重要。然后,这一发现可以启动强有力和全面的公共卫生应对措施,以尽量减少发病率和死亡率。大规模的生物恐怖主义事件将是前所未有的,给医疗和公共卫生应对的各个方面带来压力和挑战,并且由于潜在的感染风险和对全球经济的冲击,将迅速成为全球紧急情况。要有效和高效地应对这类事件,必须有一支强大的公共卫生和医疗队伍。
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引用次数: 0
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Oxford Textbook of Global Public Health
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