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MOLECULAR INTERACTIONS OF L-TYROSINE IN DIMETHYL SULFOXIDE AQUEOUS SOLUTIONS. PART 1: ELECTRONIC ABSORPTION AND FLUORESCENCE SPECTROSCOPY STUDIES l -酪氨酸在二甲基亚砜水溶液中的分子相互作用。第1部分:电子吸收和荧光光谱研究
Pub Date : 2023-02-02 DOI: 10.46991/pysu:b/2023.57.1.001
K. Grigoryan, H. Shilajyan, Roza G. Harutyunyan
Molecular interactions of L-tyrosine in dimethyl sulfoxide (DMSO) aqueous solutions have been studied using electronic absorption and fluorescence spectro¬scopy methods. It has been shown that at low concentrations of DMSO in aqueous media hetero-associates such as 1DMSO:1H2O or 1DMSO:2H2O are formed, while at high concentrations, associates of a more complex structure (mixed clusters) are formed that interact with L-tyrosine to form complex compounds.
用电子吸收和荧光光谱法研究了l -酪氨酸在二甲基亚砜(DMSO)水溶液中的分子相互作用。研究表明,在低浓度的DMSO水溶液中,会形成异缔合物,如1DMSO:1H2O或1DMSO:2H2O,而在高浓度下,会形成更复杂结构的缔合物(混合簇),与l -酪氨酸相互作用形成复杂的化合物。
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引用次数: 0
MICROMYCETES OF CONTAMINATED SOILS AROUND KAJARAN CITY (ARMENIA) 亚美尼亚卡加兰市周边污染土壤的微真菌
Pub Date : 2022-12-28 DOI: 10.46991/pysu:b/2022.56.3.253
Ruzanna E. Matevosyan
In the current research, we investigated soil micromycetes-decomposers around Kajaran City. As a result of the studies, 30 micromycetes were identified as belonging to 16 genera of which 1 belongs to Basidiomycota, 1 – to Mortierellomycota, 3 – to Mucoromycota, and 11 – to Ascomycota. Changes in the species composition and some morphological features of soil fungi are observed depending on the industrial pollution.
在本研究中,我们调查了卡加兰市附近的土壤微菌分解者。结果鉴定出30种微菌,隶属于16属,其中担子菌门1属,Mortierellomycota门1属,Mucoromycota门3属,子囊菌门11属。根据不同的工业污染,土壤真菌的种类组成和某些形态特征发生了变化。
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引用次数: 0
ASSESSMENT OF ANTIOXIDANT ACTIVITY OF SOME OROBANCHACEAE SPECIES FROM ARMENIA 亚美尼亚几种龙舌兰科植物的抗氧化活性评价
Pub Date : 2022-12-28 DOI: 10.46991/pysu:b/2022.56.3.259
Narine A. Zakaryan, Vahagn S. Gevorgyan, Nune Kartashyan, S. Nanagulyan
Holoparasitic plants of the family Orobanchaceae are represented by 36 species belonging to 4 genera in Armenia. Despite the fact that the secondary metabolites and their pharmacological properties are not well studied, the limited data on this topic is already a promising source for different bioactive compounds. In this paper, we are representing the antioxidant properties and phenolic content of four species belonging to Orobanchaceae family. The highest antioxidant activities were recorded for Orobanche kurdica alcoholic extract. Water soluble phenols may explain the great antioxidant capacity of the aqueous extract of Diphelypaea tournefortii.
亚美尼亚的全寄生植物为Orobanchaceae,共有4属36种。尽管次生代谢物及其药理学性质尚未得到很好的研究,但这一主题的有限数据已经成为不同生物活性化合物的有希望的来源。本文介绍了四种龙葵科植物的抗氧化性能和酚类物质含量。枸杞醇提物的抗氧化活性最高。水溶性酚类物质可能解释了联柏水提物具有很强的抗氧化能力。
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引用次数: 0
STUDY OF THE INTERACTION OF SINGLE-STRANDED POLYRIBOADENYLIC ACID WITH ETHIDIUM BROMIDE AND METHYLENE BLUE 单链多核糖体酸与溴化乙啶和亚甲基蓝相互作用的研究
Pub Date : 2022-12-28 DOI: 10.46991/pysu:b/2022.56.3.231
Zvart H. Movsisyan
The study of the interaction of phenothiazine dye methylene blue (MB) and phenantridine dye ethidium bromide (EtBr) with synthetic single-stranded (ss)-poly(rA) has been carried out at the ionic strength of the solution 0.1 mol, in wide interval of ligand/phosphate ratio change – P/D, by the method of absorption spectroscopy. The binding curves of MB and EtBr with ss-poly(rA) were obtained. MB was shown to interact with this polynucleotide cooperatively, while for EtBr the cooperativity was not revealed. The binding parameters of MB and EtBr with ss-poly(rA) were determined – association constant K and base number n per binding site. It was shown that both ligands bind to ss-poly(rA) at least by two modes, though the affinity of MB to the polynucleotide is higher by an order, than that of EtBr.
采用吸收光谱法研究了吩噻嗪染料亚甲基蓝(MB)和非那啶染料溴化乙啶(EtBr)与合成单链(ss)-聚(rA)在0.1 mol溶液的离子强度下,在配体/磷酸盐比变化- P/D宽区间内的相互作用。得到了MB和EtBr与ss-poly(rA)的结合曲线。MB被证明与该多核苷酸协同作用,而EtBr的协同作用未被揭示。测定了MB和EtBr与ss-poly(rA)的结合参数——结合常数K和每个结合位点的碱基数n。结果表明,这两种配体至少以两种模式与ss-poly(rA)结合,尽管MB对多核苷酸的亲和力比EtBr高一个数量级。
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引用次数: 0
WHEAT PROTEIN INCREASING THROUGH RADIATION TECHNOLOGIES 利用辐射技术提高小麦蛋白质含量
Pub Date : 2022-12-28 DOI: 10.46991/pysu:b/2022.56.3.225
L. Minasbekyan, M. Parsadanyan
The effect of various doses of γ-irradiation on the biochemical composition of the nuclear fractions of wheat seedlings has been investigated. The research results indicate a direct dependence of changes in the biochemical composition of nuclear membranes and soluble nuclear fraction on the magnitude of the radiation dose. A change in the protein content in the fraction of the nuclear membrane and in the soluble nuclear fraction of the cell nuclei of the seedlings of irradiated seeds was observed. The data obtained indicate that ionizing radiation as a result of chain reactions changes the content of nuclear fractions, which in turn leads to a change and disruption of the functional ability of the nucleus.
研究了不同剂量γ辐照对小麦幼苗核组分生化组成的影响。研究结果表明,核膜生化组成和可溶核分数的变化与辐射剂量的大小直接相关。观察到辐照种子幼苗核膜部分和细胞核可溶性核部分蛋白质含量的变化。所获得的数据表明,电离辐射作为链式反应的结果,改变了核组分的含量,这反过来又导致了细胞核功能能力的变化和破坏。
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引用次数: 0
EFFECT OF RESONANT ELECTROMAGNETIC IRRADIATION AND ASPIRIN ON SURFACE TENSION OF HUMAN BLOOD PLASMA $IN~VITRO$ 共振电磁辐照与阿司匹林对体外人血浆表面张力的影响
Pub Date : 2022-12-28 DOI: 10.46991/pysu:b/2022.56.3.218
M. Mikaelyan, M. Shahinyan, S. Grigoryan, M. Parsadanyan
In the present work the effect of resonant electromagnetic irradiation (EMI) and acetylsalicylic acid (ASA) on value change of the surface tension coefficient of human blood plasma has been studied. It was shown that both the plasma irradiation and the ASA insertion into plasma result in changing of the surface tension coefficient of human blood plasma, as well as affect the surface buffering. These changes are due to the fact that the mentioned factors invoke conformational alterations in the structures of plasma proteins, though we assume that ASA contributes in stabilization of structural changes of proteins.
本文研究了共振电磁辐射(EMI)和乙酰水杨酸(ASA)对人血浆表面张力系数值变化的影响。结果表明,等离子体辐照和ASA进入等离子体都会改变人血浆的表面张力系数,并影响其表面缓冲。这些变化是由于上述因素引起血浆蛋白结构的构象改变,尽管我们假设ASA有助于蛋白质结构变化的稳定。
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引用次数: 0
PHYSIOLOGICAL INDICATORS OF STUDENTS AFTER RUNNING A DISTANCE OF 500 METERS 学生跑完500米后的生理指标
Pub Date : 2022-12-28 DOI: 10.46991/pysu:b/2022.56.3.275
E. Gevorkyan, L. Ghukasyan, K. V. Baghdasaryan, Anahit H. Byglaryan
The change in the functional state of the body of first-year students under the influence of physical activity was studied. As the analysis of the obtained data showed, running at a distance of 500 m, both for girls and boys, leads to unidirectional shifts in all the studied indicators of varying severity. The functional systems of the organism of first-year students of the university react to physical activity by the tension of the sympathetic circuit of the regulation of adaptive mechanisms.
研究了体育锻炼对大一新生身体功能状态的影响。对所获得数据的分析表明,无论是女孩还是男孩,在500米的距离上跑步,都会导致所研究的所有指标发生不同程度的单向变化。大学一年级学生机体功能系统对体育活动的反应是通过调节适应性机制的交感神经回路的张力来实现的。
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引用次数: 0
THE EFFECT OF ANTIOXIDANT ACTIVITY OF PLANTS $TRIFOLIUM~PRATENSE$ L. AND $CRATAEGUS~LAEVIGATA$ ON LIPID PEROXIDATION IN RAT'S TISSUES EXPOSED TO HYPOBARIC HYPOXIA 三叶草和山楂抗氧化活性对低氧大鼠组织脂质过氧化的影响
Pub Date : 2022-12-28 DOI: 10.46991/pysu:b/2022.56.3.239
Irina A. Badalyan, A. Poladyan
The processes of lipid peroxidation (LPO) were studied in rat brain and liver tissues under normal conditions, as well as under conditions of hypobaric hypoxia, since it is known that hypoxia causes the development of LPO in the cells of organism tissues. It has been also studied the influense of dry flowers of Trifolium pratense L. (red clover) and Crataegus laevigata (midland hawthorn) on lipid peroxidation, which triggers by hypobaric hypoxia. It has been shown, that the end product of lipid peroxidation malondialdehyde in rat brain and liver tissues was significantly decreased with the addition of plants flowers to the diet of animals, especially in the case of C. laevigata.
由于已知缺氧可引起机体组织细胞脂质过氧化(LPO)的发生,我们研究了正常情况下大鼠脑和肝组织以及低压缺氧条件下脂质过氧化(LPO)的过程。本文还研究了红三叶草(Trifolium pratense L.)和山楂(Crataegus laevigata)干花对低气压缺氧引起的脂质过氧化的影响。有研究表明,在动物日粮中添加植物花后,大鼠脑和肝脏组织中脂质过氧化终产物丙二醛的含量显著降低,特别是在C. laevigata中。
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引用次数: 0
HYPOBARIC HYPOXIA CAUSES HISTOMORPHOLOGICAL ALTERATIONS IN THE DIFFERENT PARTS OF THE RAT'S BRAIN 低压缺氧导致大鼠大脑不同部位的组织形态学改变
Pub Date : 2022-12-28 DOI: 10.46991/pysu:b/2022.56.3.266
R. A. Shushanyan, Anna V. Grigoryan, A. Karapetyan
Hypobaric hypoxia causes degenerative changes in different parts of the brain, which leads to the formation of cerebral edema. This study aimed to investigate the morphohistological changes in the brain of rats exposed to hypobaric hypoxia. In particular, the hippocampus, cerebral cortex, and striatum were studied. Animals were exposed to hypobaric hypoxia for 10 days. Histomorphological examination showed degenerative changes in the hippocampus, dentate gyrus, and striatum, accompanied by pyknosis of neuronal nuclei, cytoplasmic vacuolization, and neuronal shrinkage, while the cortex of the large hemispheres remained almost intact. Histological studies showed that different parts of the brain respond to hypoxic conditions with different manifestations.
低气压缺氧会引起大脑不同部位的退行性变化,从而导致脑水肿的形成。本研究旨在探讨低氧缺氧大鼠脑的形态学变化。特别研究了海马体、大脑皮层和纹状体。动物暴露于低气压缺氧10天。组织形态学检查显示海马、齿状回和纹状体退行性改变,伴有神经元核固缩、细胞质空泡化和神经元萎缩,而大半球皮层基本保持完整。组织学研究表明,大脑不同部位对缺氧条件的反应有不同的表现。
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引用次数: 0
STUDY OF THE ANTIHYPOXIC EFFICIENCY OF SUCCINATE UNDER THE CONDITIONS OF METHEMOGLOBINEMIA 高铁血红蛋白血症条件下琥珀酸盐抗缺氧效率的研究
Pub Date : 2022-12-28 DOI: 10.46991/pysu:b/2022.56.3.245
Narine K. Hayrapetyan
Modeling of methemoglobinemia (MetHb) led to a violation of antioxidant protection, which was manifested by a decrease in the activity of enzymes of the primary link of the antioxidant system – superoxide dismutase and catalase in blood plasma and brain homogenates of experimental animals. The state of MetHb also led to an increase in the concentration of malondialdehyde, an indicator of lipid peroxidation, as well as an indicator of oxidative modification of proteins. It has been established that the antihypoxic activity in the application of succinic acid significantly suppresses the biochemical changes caused by the hypoxic state.
高铁血红蛋白血症(MetHb)模型导致抗氧化保护被破坏,表现为实验动物血浆和脑匀浆中抗氧化系统主要环节的酶——超氧化物歧化酶和过氧化氢酶的活性降低。甲基苯丙胺的状态也导致丙二醛的浓度增加,丙二醛是脂质过氧化的指标,也是蛋白质氧化修饰的指标。研究表明,琥珀酸的抗缺氧活性显著抑制了缺氧状态引起的生物化学变化。
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引用次数: 0
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Proceedings of the YSU B: Chemical and Biological Sciences
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