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The time of contact with the media as a potential source of behaviours similar to the features of autism spectrum disorders in children aged 6-10. 与媒体接触的时间是6-10岁儿童类似自闭症谱系障碍特征的潜在行为来源。
IF 1.1 4区 医学 Q4 PSYCHIATRY Pub Date : 2025-10-31 DOI: 10.12740/PP/193433
Małgorzata Chojak, Agnieszka Lewicka-Zelent

Objectives: The aim of the study was to see if and to what extent the length of time spent in front of a TV, computer, laptop or tablet screen differentiates the development of children.

Methods: The study included 46 girls and 55 boys aged 6-10. The children were tested with the IDS-2 test, while parents were asked to fill out questionnaires, regarding demographic information, time of contact with media and child development. Diagnosis was made for ASD, ADHD, depressive symptoms and anxiety disorders.

Results: The results indicated significant differences between children spending more than two hours a day in front of a computer or TV and those with less contact time, in terms of large motor development and the social-emotional sphere in the test used to diagnose autism.

Conclusions: The results are consistent with reports indicating a potential link between media contact time and ASD traits in children. It is therefore reasonable not only to limit the amount of time early school-age children spend in contact with the media, but also to closely monitor those who exceed this time limit.

目的:这项研究的目的是了解在电视、电脑、笔记本电脑或平板电脑屏幕前花费的时间是否以及在多大程度上区分了儿童的发展。方法:研究对象为6-10岁的46名女孩和55名男孩。孩子们接受了IDS-2测试,同时要求父母填写关于人口统计信息、接触媒体时间和儿童发展的问卷。诊断为ASD、ADHD、抑郁症状和焦虑症。结果:结果表明,在用于诊断自闭症的测试中,每天花在电脑或电视前超过两小时的儿童与接触时间较少的儿童在大运动发展和社交情感领域方面存在显著差异。结论:研究结果与媒体接触时间与儿童ASD特征之间存在潜在联系的报告一致。因此,不仅要限制学龄早期儿童接触媒体的时间,而且要密切监视那些超过这个时间限制的人,这是合理的。
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引用次数: 0
Compulsory psychiatric observation under Article 24 of the Mental Health Protection Act - legal and practical problems. 《精神健康保护法》第24条规定的强制精神病观察——法律和实际问题。
IF 1.1 4区 医学 Q4 PSYCHIATRY Pub Date : 2025-10-31 DOI: 10.12740/PP/195919
Marcin Burdzik

The Mental Health Protection Act (MHP) allows for compulsory psychiatric observation of a patient whose behaviour indicates that, due to a mental disorder, he or she is directly threatening his or her life or the life or health of others (Article 24 of the MHP). Hospitalisation is used to determine whether the disorder presented by the patient is a mental illness, within the meaning of the MHP, that is, whether it involves psychotic symptoms (Article 3(1)(a) of the MHP). Current regulations on observation are not complete, which creates numerous dilemmas when applying these provisions in medical practice. The biggest doubts relate to the possibility of reapplying Article 24 of the MHP to a patient who, after being admitted for observation, agreed to stay in the hospital and then demanded to be discharged home before settling concerns about his mental state, or the legal basis for further treatment, it is determined that there are grounds for treatment against his will. The legislator also did not comprehensively regulate the scope of diagnostic measures that can be taken against the patient's will during observation. The purpose of the article is a comprehensive analysis of the title institution with the determination of its axionormative basis, as well as an attempt to resolve the legal and practical dilemmas that arise in the course of applying Article 24 of the MHP in medical practice.

《精神健康保护法》允许对行为表明由于精神失常,他或她的生命或他人的生命或健康受到直接威胁的病人进行强制性精神病学观察(《精神健康保护法》第24条)。住院治疗用于确定患者所表现出的紊乱是否属于MHP所指的精神疾病,即是否涉及精神病症状(MHP第3(1)(a)条)。目前关于观察的规定并不完善,这在医疗实践中应用这些规定时造成了许多困境。最大的疑问是,如果病人在入院观察后,同意留在医院,然后要求在解决对其精神状态的担忧或进一步治疗的法律依据之前出院,则确定存在违背其意愿进行治疗的理由,是否有可能重新适用《医疗卫生条例》第24条。立法者也没有全面规范在观察期间可以违背患者意愿采取的诊断措施的范围。本文的目的是对标题制度进行全面分析,确定其公理基础,并试图解决在医疗实践中应用《医疗卫生法》第24条所产生的法律和实践困境。
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引用次数: 0
Parental minority stress and symptoms of depression and anxiety in women raising children in same-sex relationships. 在同性关系中养育子女的妇女的父母少数民族压力和抑郁和焦虑症状。
IF 1.1 4区 医学 Q4 PSYCHIATRY Pub Date : 2025-10-31 DOI: 10.12740/PP/OnlineFirst/190770
Jowita Wycisk, Marzenna Zakrzewska

Objectives: The purpose of this study was to examine the levels of depression and anxiety of lesbian and bisexual (LB) mothers raising children from a previous heterosexual relationship in a current same-sex relationship, on the basis of minority stress theory.

Methods: 58 LB biological mothers, 33 LB co-mothers from same-sex relationships and 60 mothers from different-sex marriages participated in a questionnaire-based online survey. The groups were compared in terms of depression and anxiety severity (state and trait). In the LB groups, correlation analysis was conducted between the dependent variables and the number of encountered negative homophobic events, the expectation of rejection, self-concealment, and internalised homophobia. To examine whether the associations between these variables in LB biological mothers and co-mothers differed, moderation analysis was used.

Results: The levels of depression and anxiety were similar across the groups. Among LB mothers, anxiety (state and trait) correlated mainly with internalised homophobia, whereas depression was linked to the expectation of rejection. Notably, among biological LB mothers, as opposed to co-mothers, there was an association between both depression and anxiety (state) and negative homophobic events.

Conclusions: The lack of intergroup differences in levels of depression and anxiety, with correlations of these variables with minority stress, may indicate high resources (e.g. family resilience) of LB mothers. The cost of homophobic events is higher for LB biological mothers than for LB co-mothers. This may be attributed to the later emergence of non-heterosexual identity in LB biological mothers who have children from heteronormative relationships, leading to a heightened sense of threat when their custody rights are challenged.

目的:本研究的目的是在少数群体压力理论的基础上,研究女同性恋和双性恋(LB)母亲在当前同性关系中抚养前异性恋子女的抑郁和焦虑水平。方法:对58名LB亲生母亲、33名同性伴侣LB共同母亲和60名不同性别婚姻的LB母亲进行在线问卷调查。比较各组的抑郁和焦虑严重程度(状态和特征)。在LB组中,因变量与遭遇负面恐同事件次数、拒绝预期、自我隐藏和内化恐同进行相关分析。为了检查这些变量在LB亲生母亲和共同母亲之间的关联是否不同,使用了适度分析。结果:两组患者的抑郁和焦虑水平相似。在LB母亲中,焦虑(状态和特质)主要与内在化的同性恋恐惧症相关,而抑郁则与被拒绝的预期相关。值得注意的是,在生物学上的LB母亲中,与共同母亲相比,抑郁和焦虑(状态)与消极的同性恋恐惧症事件之间存在关联。结论:抑郁和焦虑水平的组间差异,以及这些变量与少数民族压力的相关性,可能表明LB母亲的资源(如家庭弹性)较高。LB亲生母亲的恐同事件成本高于LB共同母亲。这可能是由于在异性恋关系中生下孩子的LB亲生母亲较晚出现非异性恋身份,当她们的监护权受到挑战时,她们的威胁意识会增强。
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引用次数: 0
The influence of mindfulness training in virtual reality on symptom severity and cognitive functioning of patients with schizophrenia and schizoaffective psychosis - a case series pilot study. 虚拟现实中正念训练对精神分裂症和分裂情感性精神病患者症状严重程度和认知功能的影响——一项病例系列先导研究
IF 1.1 4区 医学 Q4 PSYCHIATRY Pub Date : 2025-10-31 DOI: 10.12740/PP/OnlineFirst/194444
Iga Plencler, Stanisław Radoń, Andrzej Cechnicki, Przemysław Stankiewicz, Artur Daren, Aneta Kalisz, Piotr Błądziński, Marcin Siwek

Objectives: An idiographic evaluation of the effectiveness of including Mindfulness Skills Training in Virtual Reality (MST-VR) in the treatment of patients with schizophrenia disorders and its comparison with the results of a group effects analysis.

Methods: Twenty-five patients with schizophrenia and schizoaffective psychosis were assessed at 4-week intervals (one month before training, at the beginning and the end of training) using: Positive and Negative Syndrome Scale (PANSS-6), Quick Inventory of Depressive Symptomatology (QIDS), Beck Depression Inventory (BDI®-II), Beck Anxiety Inventory (BAI), State-Trait Anxiety Inventory (STAI), Perceived Stress Scale (PSS-10) and Addenbrooke's Cognitive Examination III (ACE-III). The Reliable Change Index (RCI) was used for statistical evaluation, and Cohen's d was used to assess effect size.

Results: Twenty patients (80%) achieved improvements in the severity of general symptoms, positive and negative symptoms, stress, anxiety, depression, and cognitive functioning. Individual patients showed deterioration in anxiety (2 patients, 8%) and stress (1 patient, 4%). The RCI method showed greater sensitivity in detecting changes than standard monographic statistical methods.

Conclusions: The MST-VR intervention as an adjunctive treatment for patients with schizophrenia and schizoaffective psychosis is safe and beneficial. The RCI method is valuable in assessing the dynamics of individual patient outcomes.

目的:对虚拟现实中正念技能训练(MST-VR)治疗精神分裂症患者的有效性进行具体评价,并与组效应分析结果进行比较。方法:每隔4周(训练前1个月、训练开始和结束时)对25例精神分裂症和分裂情情性精神病患者进行评估:阳性和阴性综合征量表(PANSS-6)、抑郁症状快速量表(QIDS)、贝克抑郁量表(BDI®-II)、贝克焦虑量表(BAI)、状态-特质焦虑量表(STAI)、感知压力量表(PSS-10)和阿登布鲁克认知测验III (ACE-III)。采用可靠变化指数(Reliable Change Index, RCI)进行统计评价,采用Cohen’s d评价效应大小。结果:20例患者(80%)在一般症状、阳性和阴性症状、压力、焦虑、抑郁和认知功能的严重程度上得到改善。个别患者出现焦虑(2例,8%)和应激(1例,4%)恶化。RCI方法在检测变化方面比标准的专题统计方法具有更高的灵敏度。结论:MST-VR干预作为精神分裂症和分裂情感性精神病患者的辅助治疗是安全有益的。RCI方法在评估个体患者预后的动态方面是有价值的。
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引用次数: 0
Neurobiology of creativity: is there any association with bipolar mood disorder? 创造力的神经生物学:与双相情感障碍有联系吗?
IF 1.1 4区 医学 Q4 PSYCHIATRY Pub Date : 2025-10-31 DOI: 10.12740/PP/200401
Janusz Rybakowski

Creativity can be defined as a production of action or idea both original and useful, and its effective implementation. Such features of brain functioning may have an evolutionary advantage, increasing chances of survival and achieving reproductive success. Creativity occurs already in some animals but to the greatest extent is present in contemporary humans. The number of genes implicitly associated with creativity is greater in Homo sapiens compared with Homo neandenthalesis, in which it exceeds the number occurring in chimpanzees. The brain structures most essential for creativity involve the frontal and temporal lobes, the default mode network and the cerebellum, and the main neurotransmitter system is the dopaminergic one. Psychological processes associated with creativity include unusual mode of thinking and increased motivation driven by mood. In the field of psychopathology, most data make a case for the association of creativity with bipolar mood disorder (BD). Among writers, artists and their families, there is an overrepresentation of BD and cyclothymic personality. In BD, unusual thinking is frequent, and enhanced creativity is usually associated with elevated mood. The studies of Nancy Andreasen, Kay Jamison, Terence Ketter, Tiffany Greenwood, and own investigation in this area are presented. The results of many analyses point to a shared vulnerability to creativity and BD. In many outstanding artists, including Polish ones, we observe the full clinical expression of the illness.

创造力可以定义为原创和有用的行动或想法的产生,以及它的有效实施。大脑功能的这些特征可能具有进化优势,增加了生存和繁殖成功的机会。创造力在一些动物中已经存在,但在当代人类中最大程度地存在。与尼安德特人相比,智人中隐含与创造力相关的基因数量更多,而尼安德特人的数量超过了黑猩猩。对创造力最重要的大脑结构包括额叶和颞叶、默认模式网络和小脑,主要的神经递质系统是多巴胺能系统。与创造力相关的心理过程包括不寻常的思维模式和由情绪驱动的动力增强。在精神病理学领域,大多数数据表明创造力与双相情绪障碍(BD)有关。在作家、艺术家和他们的家庭中,双相障碍和循环型人格的比例过高。在双相障碍患者中,不寻常的思维经常出现,而创造力的增强通常与情绪高涨有关。介绍了Nancy Andreasen、Kay Jamison、Terence Ketter、Tiffany Greenwood的研究以及自己在这方面的调查。许多分析的结果都指向了创造力和双相障碍的共同弱点。在许多杰出的艺术家身上,包括波兰艺术家,我们观察到这种疾病的完整临床表现。
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引用次数: 0
Binge drinking among adolescents: role of temperament, family environment and peers. 青少年酗酒:气质、家庭环境和同伴的作用。
IF 1.1 4区 医学 Q4 PSYCHIATRY Pub Date : 2025-10-31 DOI: 10.12740/PP/194034
Magdalena Chęć, Krystian Konieczny, Karolina Rachubińska, Agnieszka Samochowiec

Objectives: Adolescence is a development stage between childhood and adulthood, which involves the intense physical, mental, and social development of a person. Adolescents are at risk of engaging in risky behaviours, most notably the use of psychoactive substances, including binge drinking. Factors involving family, peers and individual differences may protect this age group from or put them at risk of abusing alcohol. The aim of the study was to describe the relation between temperament, family and peer factors, and the frequency of binge drinking among adolescents.

Methods: The survey was conducted among 825 students of primary and secondary schools in Szczecin (West Pomeranian Voivodeship, Poland), aged 13-16 (13.83 years old, 52.2% boys). The EATQ-R: "The class towards me" (A) and "I towards the class" (B), Family Assessment Scales (SOR) based on FACES IV and an original survey were used in the study.

Results: Statistically significant links were found between the manifested temperament features and the prevalence of adolescent binge drinking. Relevant relations were found between the assessment of family functioning and family behaviour. It was also revealed that the way the leisure time was spent with friends was strongly associated with the prevalence of binge drinking.

Conclusions: The studied areas indicate existing relationships between the selected variables.

目的:青春期是介于童年和成年之间的一个发展阶段,涉及一个人的身体、精神和社会的强烈发展。青少年有从事危险行为的危险,最明显的是使用精神活性物质,包括酗酒。涉及家庭、同伴和个体差异的因素可能保护这一年龄组免于或使他们处于滥用酒精的危险之中。该研究的目的是描述气质、家庭和同伴因素与青少年酗酒频率之间的关系。方法:对波兰什切青(西波美拉尼亚省)825名13 ~ 16岁的中小学生进行调查,其中年龄13.83岁,男生占52.2%。本研究采用了基于FACES IV的家庭评估量表(SOR):“班级对我”(A)和“我对班级”(B)。结果:气质特征与青少年酗酒患病率之间存在统计学上的显著联系。发现家庭功能评估与家庭行为之间存在相关关系。研究还发现,与朋友一起度过闲暇时光的方式与酗酒的流行程度密切相关。结论:研究区域表明了所选变量之间存在的关系。
{"title":"Binge drinking among adolescents: role of temperament, family environment and peers.","authors":"Magdalena Chęć, Krystian Konieczny, Karolina Rachubińska, Agnieszka Samochowiec","doi":"10.12740/PP/194034","DOIUrl":"https://doi.org/10.12740/PP/194034","url":null,"abstract":"<p><strong>Objectives: </strong>Adolescence is a development stage between childhood and adulthood, which involves the intense physical, mental, and social development of a person. Adolescents are at risk of engaging in risky behaviours, most notably the use of psychoactive substances, including binge drinking. Factors involving family, peers and individual differences may protect this age group from or put them at risk of abusing alcohol. The aim of the study was to describe the relation between temperament, family and peer factors, and the frequency of binge drinking among adolescents.</p><p><strong>Methods: </strong>The survey was conducted among 825 students of primary and secondary schools in Szczecin (West Pomeranian Voivodeship, Poland), aged 13-16 (13.83 years old, 52.2% boys). The EATQ-R: \"The class towards me\" (A) and \"I towards the class\" (B), Family Assessment Scales (SOR) based on FACES IV and an original survey were used in the study.</p><p><strong>Results: </strong>Statistically significant links were found between the manifested temperament features and the prevalence of adolescent binge drinking. Relevant relations were found between the assessment of family functioning and family behaviour. It was also revealed that the way the leisure time was spent with friends was strongly associated with the prevalence of binge drinking.</p><p><strong>Conclusions: </strong>The studied areas indicate existing relationships between the selected variables.</p>","PeriodicalId":20863,"journal":{"name":"Psychiatria polska","volume":"59 5","pages":"755-768"},"PeriodicalIF":1.1,"publicationDate":"2025-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145912872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the "PsychoŻak" mental health promotion programme for university students. Report of a pilot study. 对“PsychoŻak”大学生心理健康促进方案的评价。试点研究报告。
IF 1.1 4区 医学 Q4 PSYCHIATRY Pub Date : 2025-10-20 DOI: 10.12740/PP/OnlineFirst/202106
Lidia Zabłocka-Żytka, Ewa Sokołowska, Sylwia Kluczyńska

Objectives: This article presents the results of the evaluation of the pilot of the "PsychoŻak" mental health promotion programme for university students. The main aim of the "PsychoŻak" programme is to enhance students' well-being in the mental (including emotional and cognitive), physical/somatic and social spheres, which is in line with the previously researched expectations of young adults towards mental health promotion.

Methods: A comparison was made between selected mental health indicators and the mental health knowledge and competences of participants before and after taking part in the mental health promotion programme. An evaluation questionnaire on the content presented in the programme and the General Health Questionnaire (GHQ-28) were used.

Results: The analysis of the collected data indicates an increase in mental health knowledge and competences after participation in the mental health promotion programme. Most of the observed differences were statistically significant. Participants in the mental health promotion programme were also characterised by better mental health indicators, as measured by the GHQ-28, after completing the programme.

Conclusions: The evaluation of the pilot implementation of the "PsychoŻak" mental health promotion programme for university students confirms that the intended effects have been achieved and supports the programme's relevance for universities.

目的:介绍“PsychoŻak”大学生心理健康促进项目试点的评价结果。“PsychoŻak”方案的主要目的是提高学生在心理(包括情感和认知)、身体/身体和社会领域的健康,这符合先前研究的年轻人对促进心理健康的期望。方法:对参与心理健康促进活动前后被试所选心理健康指标与心理健康知识和能力进行比较。使用了一份关于方案内容的评价调查表和一般健康调查表(GHQ-28)。结果:收集的数据分析表明,参加心理健康促进计划后,心理健康知识和能力有所提高。大多数观察到的差异具有统计学意义。心理健康促进方案的参与者在完成方案后,根据GHQ-28衡量的心理健康指标也有所改善。结论:对“PsychoŻak”大学生心理健康促进方案试点实施情况的评价证实,该方案已达到预期效果,并支持该方案与高校的相关性。
{"title":"Evaluation of the \"PsychoŻak\" mental health promotion programme for university students. Report of a pilot study.","authors":"Lidia Zabłocka-Żytka, Ewa Sokołowska, Sylwia Kluczyńska","doi":"10.12740/PP/OnlineFirst/202106","DOIUrl":"https://doi.org/10.12740/PP/OnlineFirst/202106","url":null,"abstract":"<p><strong>Objectives: </strong>This article presents the results of the evaluation of the pilot of the \"PsychoŻak\" mental health promotion programme for university students. The main aim of the \"PsychoŻak\" programme is to enhance students' well-being in the mental (including emotional and cognitive), physical/somatic and social spheres, which is in line with the previously researched expectations of young adults towards mental health promotion.</p><p><strong>Methods: </strong>A comparison was made between selected mental health indicators and the mental health knowledge and competences of participants before and after taking part in the mental health promotion programme. An evaluation questionnaire on the content presented in the programme and the General Health Questionnaire (GHQ-28) were used.</p><p><strong>Results: </strong>The analysis of the collected data indicates an increase in mental health knowledge and competences after participation in the mental health promotion programme. Most of the observed differences were statistically significant. Participants in the mental health promotion programme were also characterised by better mental health indicators, as measured by the GHQ-28, after completing the programme.</p><p><strong>Conclusions: </strong>The evaluation of the pilot implementation of the \"PsychoŻak\" mental health promotion programme for university students confirms that the intended effects have been achieved and supports the programme's relevance for universities.</p>","PeriodicalId":20863,"journal":{"name":"Psychiatria polska","volume":" ","pages":"1-18"},"PeriodicalIF":1.1,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146100763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond anti-psychotics: the perspective of treating negative and cognitive symptoms with a combination of anti-dementia drugs. 超越抗精神病药物:联合抗痴呆药物治疗阴性和认知症状的视角。
IF 1.1 4区 医学 Q4 PSYCHIATRY Pub Date : 2025-10-05 DOI: 10.12740/PP/OnlineFirst/202253
Stefan Modzelewski, Aleksandra Julia Oracz, Maria Suprunowicz, Napoleon Waszkiewicz

Schizophrenia is a severe psychiatric disorder characterised by a broad spectrum of symptoms, including psychotic, negative and cognitive symptoms. Despite advances in antipsychotic treatment, current therapies do not fully alleviate negative and cognitive symptoms, making it difficult for patients to function adequately in society. Recent research suggests that combining anti-dementia drugs, specifically galantamine and memantine, with standard neuroleptic treatment may offer a novel approach to improving these symptoms. This paper explores the mechanisms of action of galantamine and memantine, their potential synergistic effects and their impact on key pathways implicated in schizophrenia, such as the cholinergic, glutamatergic and kynurenine pathways. The combination of these drugs shows promise in enhancing cognitive functions and reducing negative symptoms, potentially leading to better overall outcomes for patients with schizophrenia. However, further clinical trials are needed to validate these findings and optimise treatment protocols.

精神分裂症是一种严重的精神障碍,其特点是症状广泛,包括精神病性、阴性和认知症状。尽管在抗精神病治疗方面取得了进展,但目前的治疗方法并不能完全缓解消极和认知症状,使患者难以在社会中充分发挥作用。最近的研究表明,结合抗痴呆药物,特别是加兰他明和美金刚,与标准的抗精神病药物治疗可能提供一种改善这些症状的新方法。本文探讨了加兰他敏和美金刚的作用机制,它们潜在的协同作用,以及它们对精神分裂症的关键通路,如胆碱能、谷氨酸能和犬尿氨酸通路的影响。这些药物的组合在增强认知功能和减少阴性症状方面显示出希望,可能会给精神分裂症患者带来更好的总体结果。然而,需要进一步的临床试验来验证这些发现并优化治疗方案。
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引用次数: 0
What do the GWAS Studies Say About Language in Schizophrenia. GWAS研究如何解释精神分裂症患者的语言?
IF 1.1 4区 医学 Q4 PSYCHIATRY Pub Date : 2025-09-23 DOI: 10.12740/PP/OnlineFirst/208424
Przemysław Zakowicz, Bartłomiej Sporniak, Maksymilian Grabarczyk, Maria Skibińska, Joanna Pawlak

Introduction: Schizophrenia links with altered language structure and may be evolutionary consequence of language development. High heritability of the disease led to recent endeavour in explaining the genetic background. Genome-Wide Association Studies (GWAS) indicate schizophrenia as highly polygenic disease with many receptor and synaptic plasticity pathways engaged.

Material and methods: Here we present a systematic review on the topic of schizophrenia GWAS findings and its potential relevance to language skills. We used GWAS catalog data to identify all significant associations in schizophrenia (including selected endophenotypes) and studied its relevance in the context of published data on language phenotypes associations.

Results: Among genes involved in language evolution, FOXP1 and ROBO2 were indicated by GWAS as associated with schizophrenia. Evidence on schizophrenia linked SNPs was found for association with intelligence, educational attainment, cognitive abilities and language processing brain structures imaging results.

Conclusions: The review discusses hypotheses of language alterations in schizophrenia as a consequence of impaired synaptic plasticity and neural network formation.

精神分裂症与语言结构改变有关,可能是语言发展的进化结果。这种疾病的高遗传性促使人们最近努力解释其遗传背景。全基因组关联研究(GWAS)表明,精神分裂症是一种高度多基因疾病,涉及许多受体和突触可塑性途径。材料和方法:在这里,我们对精神分裂症GWAS的研究结果及其与语言技能的潜在相关性进行了系统的综述。我们使用GWAS目录数据来确定精神分裂症的所有重要关联(包括选定的内表型),并在已发表的语言表型关联数据的背景下研究其相关性。结果:在参与语言进化的基因中,GWAS提示FOXP1和ROBO2与精神分裂症相关。有证据表明,与精神分裂症相关的snp与智力、受教育程度、认知能力和语言处理大脑结构成像结果有关。结论:本文讨论了精神分裂症中语言改变是突触可塑性和神经网络形成受损的结果的假设。
{"title":"What do the GWAS Studies Say About Language in Schizophrenia.","authors":"Przemysław Zakowicz, Bartłomiej Sporniak, Maksymilian Grabarczyk, Maria Skibińska, Joanna Pawlak","doi":"10.12740/PP/OnlineFirst/208424","DOIUrl":"https://doi.org/10.12740/PP/OnlineFirst/208424","url":null,"abstract":"<p><strong>Introduction: </strong>Schizophrenia links with altered language structure and may be evolutionary consequence of language development. High heritability of the disease led to recent endeavour in explaining the genetic background. Genome-Wide Association Studies (GWAS) indicate schizophrenia as highly polygenic disease with many receptor and synaptic plasticity pathways engaged.</p><p><strong>Material and methods: </strong>Here we present a systematic review on the topic of schizophrenia GWAS findings and its potential relevance to language skills. We used GWAS catalog data to identify all significant associations in schizophrenia (including selected endophenotypes) and studied its relevance in the context of published data on language phenotypes associations.</p><p><strong>Results: </strong>Among genes involved in language evolution, FOXP1 and ROBO2 were indicated by GWAS as associated with schizophrenia. Evidence on schizophrenia linked SNPs was found for association with intelligence, educational attainment, cognitive abilities and language processing brain structures imaging results.</p><p><strong>Conclusions: </strong>The review discusses hypotheses of language alterations in schizophrenia as a consequence of impaired synaptic plasticity and neural network formation.</p>","PeriodicalId":20863,"journal":{"name":"Psychiatria polska","volume":" ","pages":"1-15"},"PeriodicalIF":1.1,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145482755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychiatric disorders among adolescents residing at Youth Educational Centers in Silesia in Poland. 居住在波兰西里西亚青年教育中心的青少年的精神疾病。
IF 1.1 4区 医学 Q4 PSYCHIATRY Pub Date : 2025-09-10 DOI: 10.12740/PP/OnlineFirst/207301
Karolina Zofia Kamińska, Michał Ciołek, Izabela Rosół, Magdalena Matlakiewicz, Maria Potaczek, Lena Cichoń, Krzysztof Maria Wilczyński, Małgorzata Janas-Kozik

Objectives: In Polish Youth Educational Centres underage individuals exhibiting signs of delinquency are accommodated. A significant concern is the presence of mental health disorders among these institutions' residents, which may influence their rehabilitation process. The aim of this study was to evaluate the prevalence of mental health disorders among residents of Youth Educational Centres in the Silesian Voivodeship.

Methods: The study was conducted between February and November 2022 in two Youth Educational Centres located in the Silesian Voivodeship. 80 individuals participated in the study (60% boys, 40% girls). Participation was voluntary and anonymous. A semi-structured psychiatric interview K-SADS-PL was employed, incorporating questionnaires covering mania, depression, conduct disorders, and substance use disorders.

Results: Among the study participants, 12.5% (n = 10) had been diagnosed with mental disorders prior to the start of the study. Criteria for Major Depressive Disorder were met by 26.25% of participants, including 20.8% of boys and 34.37% of girls, with irritability reported in 19 of the 21 individuals diagnosed with depression. Conduct disorders were observed in 52.5% of participants. Furthermore, 39% of respondents consumed alcohol at least three times per week, and 70% used cannabis at least once a week.

Conclusions: Research on the mental health of adolescents in Youth Educational Centres in Poland highlights a high prevalence of depressive disorders and problematic patterns of psychoactive substance use among residents, which may negatively impact their functioning and prognosis. Interventions are essential to facilitate beneficial behavioural changes in these minors and to counteract their demoralisation.

目标:在波兰青年教育中心,有犯罪迹象的未成年人被安置。令人严重关切的是,这些机构的住客中存在精神健康障碍,这可能影响他们的康复过程。这项研究的目的是评估西里西亚省青年教育中心居民中精神健康障碍的患病率。方法:研究于2022年2月至11月在西里西亚省的两个青年教育中心进行,共有80人参加了研究(60%为男孩,40%为女孩)。参与是自愿和匿名的。采用半结构化精神病学访谈K-SADS-PL,包括躁狂、抑郁、行为障碍和物质使用障碍问卷。结果:在研究参与者中,12.5% (n = 10)在研究开始前被诊断患有精神障碍。26.25%的参与者符合重度抑郁症的标准,其中包括20.8%的男孩和34.37%的女孩,21名被诊断为抑郁症的人中有19人易怒。52.5%的参与者存在行为障碍。此外,39%的答复者每周至少饮酒三次,70%的人每周至少吸食一次大麻。结论:关于波兰青年教育中心青少年心理健康的研究突出表明,居民中抑郁症和精神活性物质使用问题模式的患病率很高,这可能对他们的功能和预后产生负面影响。干预措施对于促进这些未成年人有益的行为改变和消除他们的士气低落至关重要。
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引用次数: 0
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