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Editorial. 社论
IF 0.9 4区 医学 Q4 PSYCHIATRY Pub Date : 2024-06-30 DOI: 10.12740/PP/191451
Dominika Dudek, Jerzy A Sobański, Katarzyna Klasa

no summary.

无摘要。
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引用次数: 0
Polish Adaption of Pregnancy-Related Anxiety Questionnaire - Revised 2 (PRAQ-R2). 波兰语改编的妊娠相关焦虑问卷--修订版 2 (PRAQ-R2)。
IF 0.9 4区 医学 Q4 PSYCHIATRY Pub Date : 2024-06-30 DOI: 10.12740/PP/OnlineFirst/156324
Agata Mikolajkow, Tomasz Fuchs, Krzysztof Małyszczak

Aim: To create a Polish adaption of the Pregnancy-Related Anxiety Questionnaire - Revised 2 (PRAQ-R2), which is widely used abroad.

Methods: PRAQ-R2 was translated into Polish by independent bilingual speakers. Fortyeight pregnant women completed our survey containing the Polish version of PRAQ-R2, Hospital Anxiety and Depression Scale - Modified (HADS-M), and a short sociodemographic questionnaire. After a week, they were asked to complete the PRAQ-R2 questionnaire again. Parametric statistics were used to assess psychometric properties.

Results: Our study has shown a good test-retest correlation of 0.70. Participants completed the survey twice (in t1 and after one week - in t2). Cronbach's alpha was calculated as 0.847 at t1 and 0.895 at t2. There was a moderate correlation between PRAQ-R2 at both time points and the HADS-M scale and its subscales.

Conclusions: Our Polish adaption of PRAQ-R2 has shown good validity and reliability. It has good internal consistency. Moderate correlation with HADS-M proves that pregnancyrelated anxiety (PrA) is a distinctive disorder from generalized anxiety disorder and depressive disorder. Given the great frequency and the burden of PrA, we believe that PRAQ-R2 should be routinely used among physicians working with pregnant patients.

目的:将国外广泛使用的妊娠相关焦虑问卷--修订版2(PRAQ-R2)改编成波兰语:方法:PRAQ-R2 由独立的双语人士翻译成波兰语。48 名孕妇填写了我们的调查问卷,其中包括波兰语版 PRAQ-R2、医院焦虑抑郁量表--修订版(HADS-M)和一份简短的社会人口学问卷。一周后,她们被要求再次填写 PRAQ-R2 问卷。我们使用参数统计来评估心理测量特性:我们的研究显示出良好的测试-再测相关性(0.70)。参与者完成了两次调查(t1 和一周后的 t2)。经计算,t1 和 t2 的 Cronbach's alpha 分别为 0.847 和 0.895。两个时间点的 PRAQ-R2 与 HADS-M 量表及其分量表之间存在中等程度的相关性:我们在波兰改编的 PRAQ-R2 具有良好的有效性和可靠性。它具有良好的内部一致性。与 HADS-M 的适度相关性证明,与妊娠相关的焦虑(PrA)是一种不同于广泛性焦虑症和抑郁症的疾病。鉴于妊娠相关焦虑症的高发率和沉重负担,我们认为 PRAQ-R2 应在为妊娠患者服务的医生中常规使用。
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引用次数: 0
Borderlines of psychosis - nosological propositions of Polish psychiatrists of the interwar period. 精神病的边界线--战时波兰精神病学家的分类学主张。
IF 0.9 4区 医学 Q4 PSYCHIATRY Pub Date : 2024-06-30 DOI: 10.12740/PP/171677
Jan Kornaj

This paper examines nosological categories relating to borderlines between psychosis and other clinical categories, introduced by Polish psychiatrists in the interwar period. In the United States, the discussion about the borderline between neuroses and psychoses was urged by the 1938 article by psychoanalyst Adolph Stern. In Poland, nosological categories regarding the borderline between neuroses and psychoses were proposed by Adam Wizel, Maurycy Bornsztajn, Jan Nelken, and Władysław Matecki. Wizel coined the term 'underdeveloped schizophrenia', Bornsztajn introduced 'schizothymia reactiva' and 'hypochondriac (somatopsychic) schizophrenia', Nelken described 'mild schizophrenia', first introduced by Moscow psychiatric school of Rosenstein, and Matecki presented the category of neurosis-like (pseudo-neurotic) schizophrenia. Additionally, Julian Dretler, after studying the borderline between schizophrenia and manic-depressive psychosis, coined the term 'mixed psychosis' and expressed conviction that it is an independent nosological entity. Like in the United States, the majority of Polish pioneers of the nosological studies of borderline cases were influenced by psychoanalysis. As a consequence of World War II and the new regime, which forced dialectical materialism and Pavlovism as an official ideology of psychiatry and condemned psychoanalysis, the categories presented in the article became forgotten and have not impacted Polish psychiatric nosology.

本文研究了波兰精神病学家在战时提出的与精神病和其他临床类别之间的边界线有关的疾病分类。在美国,精神分析学家阿道夫-斯特恩(Adolph Stern)于1938年发表的文章推动了关于神经官能症和精神病之间边界线的讨论。在波兰,亚当-维泽尔(Adam Wizel)、莫里西-博恩斯塔伊恩(Maurycy Bornsztajn)、扬-内尔肯(Jan Nelken)和瓦迪斯瓦夫-马特茨基(Władysław Matecki)提出了关于神经官能症和精神病之间边界线的命名分类。维泽尔创造了 "发育不全型精神分裂症 "这一术语,博恩斯塔因提出了 "反应性精神分裂症 "和 "臆想型(躯体精神)精神分裂症",奈尔肯描述了 "轻度精神分裂症",这是莫斯科罗森斯坦精神病学派首先提出的,而马特基提出了神经症样(假神经症)精神分裂症这一类别。此外,朱利安-德雷特勒(Julian Dretler)在研究了精神分裂症和躁狂抑郁性精神病之间的界限后,创造了 "混合型精神病 "这一术语,并坚信这是一个独立的命名实体。与美国一样,波兰大多数对边缘病例进行分类学研究的先驱都受到了精神分析的影响。第二次世界大战和新政权迫使辩证唯物主义和巴甫洛夫主义成为精神病学的官方意识形态,并谴责精神分析,因此文章中提出的分类已被遗忘,也没有对波兰的精神病分类学产生影响。
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引用次数: 0
A study on the attitude of Polish psychotherapists towards online therapy - Polish adaptation of the UTAUT-T (Unified Theory of Acceptance and Use of Technology - Therapist version) and verification of the UTAUT-T model. 波兰心理治疗师对在线治疗的态度研究--UTAUT-T(接受和使用技术统一理论--治疗师版)波兰语改编版及UTAUT-T模型验证。
IF 0.9 4区 医学 Q4 PSYCHIATRY Pub Date : 2024-06-30 DOI: 10.12740/PP/OnlineFirst/159445
Agnieszka Koch, Agata Graczykowska, Szymon Szumiał, Magdalena Marszał-Wiśniewska

Objectives: The aim of the study was to verify the psychometric properties of the Polish adaptation of the Unified Theory of Acceptance and Use of Technology - Therapist version (UTAUT-T) and to verify the UTAUT-T model in a group of Polish psychotherapists.

Methods: A total of 434 people aged 27-66 (M = 40.78; SD = 7.70), including 337 women and 58 men, took part in an online self-report study, which involved completing three questionnaires: UTAUT-T, the short IPIP-BFM-20 Questionnaire for measuring the Big Five, the Technology Readiness Index (TRI 2.0), as well as answers to questions about the use of digital technologies at work. The following analyses were carried out: confirmatory factor analysis (CFA), reliability analysis using Cronbach's alpha, and theoretical validity analysis - an analysis of the correlation between the subscales of the UTAUT-T instrument and questionnaires enabling the measurement of dimensions which had been indicated in previous research results as related to the acceptance of technology.

Results: The conducted analyses showed that the factor structure of the Polish version of UTAUT-T is the same as of the original tool, and the UTAUT-T model was confirmed in the group of Polish psychotherapists. The Cronbach's alpha reliability coefficient for individual subscales ranged from 0.57 to 0.97. The theoretical validity analysis confirmed the expected correlations between most dimensions of technology acceptance and technology readiness. In addition, there were single very weak correlations observed between technology acceptance and personality traits.

Conclusions: The psychometric properties of the Polish version of UTAUT-T show satisfactory values. The scale can be used to conduct further research. The UTAUT-T model can be utilized to predict the actual use of new technologies by Polish psychotherapists.

研究目的研究的目的是验证波兰语改编的 "接受和使用技术统一理论-治疗师版"(UTAUT-T)的心理测量特性,并在一组波兰心理治疗师中验证UTAUT-T模型:共有 434 名年龄在 27-66 岁之间的人员(M = 40.78;SD = 7.70)参加了在线自我报告研究,其中包括 337 名女性和 58 名男性,他们填写了三份问卷:UTAUT-T、用于测量 "五大 "的 IPIP-BFM-20 短问卷、技术就绪指数(TRI 2.0),以及有关工作中数字技术使用情况的问题答案。我们进行了以下分析:确认性因素分析(CFA)、使用克朗巴赫α进行的可靠性分析以及理论有效性分析--UTAUT-T 工具的子量表与问卷之间的相关性分析,以便测量以往研究结果表明与技术接受度有关的维度:分析结果表明,波兰语版UTAUT-T的因子结构与原版工具相同,UTAUT-T模型在波兰心理治疗师群体中得到了证实。各分量表的 Cronbach's alpha 信度系数介于 0.57 和 0.97 之间。理论有效性分析证实,技术接受度的大多数维度与技术准备度之间存在预期的相关性。此外,还观察到技术接受度与人格特质之间存在单一的非常弱的相关性:波兰语版UTAUT-T的心理测量属性显示出令人满意的数值。该量表可用于开展进一步研究。UTAUT-T模型可用于预测波兰心理治疗师对新技术的实际使用情况。
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引用次数: 0
Relational trauma. 关系创伤
IF 0.9 4区 医学 Q4 PSYCHIATRY Pub Date : 2024-06-30 DOI: 10.12740/PP/OnlineFirst/156722
Dorota Draczyńska

The aim of this paper is to briefly present the current knowledge on the definition of relational trauma, place in classifications, prevalence, consequences, and applied therapeutic methods. Reports from many countries indicate that in the relationship with adults, usually parents, on whom the child is dependent for many years, various forms of abuse may occur, related not only to violence, but also to emotional, physical, and intellectual neglect. Behind them, the unregistered area of aversive experiences of children who enter adulthood with the experience of relational trauma is hidden. These adverse childhood experiences significantly affect overall functioning in adulthood. For years, researchers of the phenomenon have been paying attention to the existence of a separate diagnosis related to relational trauma. The 11th edition of the International Classification of Diseases (ICD-11) introduces a new diagnosis: complex post-traumatic stress disorder (Complex PTSD, cPTSD). New methods of therapeutic interventions emerge, and the validation of these methods and explanation of the mechanisms of action is research work for the coming years.

本文旨在简要介绍关系创伤的定义、分类、流行程度、后果和应用治疗方法等方面的现有知识。来自许多国家的报告显示,在与成年人(通常是父母)的关系中,儿童可能会受到各种形式的虐待,这些虐待不仅与暴力有关,还与情感、身体和智力上的忽视有关。在这些事件的背后,隐藏着儿童进入成年后未登记的逆反经历,他们经历了亲情创伤。这些不利的童年经历严重影响了成年后的整体功能。多年来,这一现象的研究人员一直在关注是否存在与亲情创伤相关的独立诊断。第 11 版《国际疾病分类》(ICD-11)引入了一项新的诊断:复杂创伤后应激障碍(Complex PTSD,cPTSD)。新的治疗干预方法不断涌现,验证这些方法并解释其作用机制是未来几年的研究工作。
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引用次数: 0
The evolutionary and neurobiological attributes of consciousness: an update. 意识的进化和神经生物学属性:最新进展。
IF 0.9 4区 医学 Q4 PSYCHIATRY Pub Date : 2024-06-30 DOI: 10.12740/PP/174391
Janusz Rybakowski, Filip Rybakowski

Consciousness is most frequently defined as a subjective experience of mental processes. The phenomenon of consciousness has always been a subject of great interest in various fields of science, including psychiatry, and the most prominent scientists have engaged in research on it. The studies performed in recent years have brought about novel data on the evolutionary and neurobiological attributes of this phenomenon. In the first part of the article, the evolutionary concepts of consciousness are presented, going back to the beginnings of life on our planet. They are proposed by such illustrious scientists as Joseph LeDoux, Daniel Dennett, António Damásio, and Arthur Reber. Each of them presents the issue of consciousness in the context of evolution slightly differently. However, there are many similarities concerning the development of the nervous system and mental life. The second part discusses the novel research on the cognitive and neurobiological components of consciousness. Among many researchers of this issue, we chose the achievements of two British authors such as Chris Frith and Anil Seth. The neuroanatomical and perceptive aspects of both the level and context of consciousness are provided. Besides presenting the contemporary evolutionary and neurobiological concepts of consciousness, the article aims to bring closer the profiles of the prominent researchers of neuroscience mentioned here. This term can be translated into Polish as "neuronauka", although our country's most frequently used name is "neurobiologia."

意识最常被定义为对心理过程的主观体验。意识现象一直是包括精神病学在内的各个科学领域非常感兴趣的课题,最著名的科学家都从事过这方面的研究。近年来进行的研究为这一现象的进化和神经生物学属性带来了新的数据。文章的第一部分介绍了意识的进化概念,可以追溯到我们星球上生命的起源。这些概念是由约瑟夫-勒杜(Joseph LeDoux)、丹尼尔-丹尼特(Daniel Dennett)、安东尼奥-达马西奥(António Damásio)和阿瑟-雷伯(Arthur Reber)等杰出科学家提出的。他们每个人对进化论中的意识问题的表述都略有不同。不过,他们在神经系统和精神生活的发展方面有许多相似之处。第二部分讨论了关于意识的认知和神经生物学组成部分的新研究。在本期的众多研究者中,我们选择了克里斯-弗里斯和阿尼尔-塞思这两位英国作者的成果。他们从神经解剖学和感知学两个方面介绍了意识的水平和背景。除了介绍当代意识的进化和神经生物学概念外,这篇文章还旨在拉近这里提到的著名神经科学研究人员的距离。这一术语在波兰语中可翻译为 "neuronauka",尽管我国最常用的名称是 "neurobiologia"。
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引用次数: 0
Management of nicotine dependence in patients with psychiatric disorders - recommendations of the Polish Psychiatric Association - part I. 精神病患者的尼古丁依赖管理--波兰精神病学协会的建议--第一部分。
IF 0.9 4区 医学 Q4 PSYCHIATRY Pub Date : 2024-06-30 DOI: 10.12740/PP/OnlineFirst/161773
Marcin Wojnar, Piotr Wierzbiński, Jerzy Samochowiec, Joanna Rymaszewska, Krzysztof J Filipiak, Adam Wichniak, Robert Mróz, Artur Mamcarz, Dominika Dudek

Smoking and nicotine dependence are still one of the main reasons for a number of serious and life-shortening somatic diseases. At the same time, they are more prevalent in mentally ill individuals than in the general population. This work, which constitutes the first part of recommendations of the Polish Psychiatric Association, presents the scale of the phenomenon in the general population and among people with psychiatric disorders, diagnostic criteria of nicotine dependence and nicotine withdrawal. It discusses the impact of smoking and exposure to cigarette smoke on the development and course of psychiatric disorders as well as on the treatment of psychiatric disorders, including interactions between nicotine and psychotropic medications. Many psychiatric patients can reduce smoking or achieve complete abstinence if they are offered adequate motivation and therapeutic support. Contrary to popular belief, smoking cessation and nicotine dependence treatment do not negatively affect the symptoms of psychiatric disorders; patients' mental conditions can improve following smoking cessation therapy. The best results in terms of maintaining abstinence are achieved with a treatment approach that combines pharmacotherapy with psychotherapeutic intervention integrated into routine psychiatric care.

吸烟和尼古丁依赖仍然是许多严重和缩短寿命的躯体疾病的主要原因之一。同时,与普通人相比,吸烟和尼古丁依赖在精神病患者中更为普遍。这部著作是波兰精神病学协会建议的第一部分,介绍了这一现象在普通人群和精神病患者中的规模、尼古丁依赖和尼古丁戒断的诊断标准。报告讨论了吸烟和接触香烟烟雾对精神疾病的发展和病程以及对精神疾病治疗的影响,包括尼古丁与精神药物之间的相互作用。如果有足够的动力和治疗支持,许多精神病患者可以减少吸烟或完全戒烟。与普遍的看法相反,戒烟和尼古丁依赖治疗不会对精神疾病的症状产生负面影响;患者的精神状况在戒烟治疗后会得到改善。将药物治疗与心理治疗干预相结合的治疗方法与常规精神治疗相结合,可以取得最佳的戒烟效果。
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引用次数: 0
The internment of patients undergoing treatment for alcohol addiction as a result of a specific interpretation of legal provisions by some judicial authorities. 由于某些司法当局对法律规定的特殊解释,正在接受酒精成瘾治疗的病人被拘留。
IF 0.9 4区 医学 Q4 PSYCHIATRY Pub Date : 2024-06-30 DOI: 10.12740/PP/OnlineFirst/155390
Kamila Kocańda, Stanisław Głuszek, Rafał Łoś, Beata Matulińska, Dariusz Zwierzchowski, Agnieszka Zwierzchowska-Łucka

In the Polish legal system, each medical procedure requires patient's consent. Exemptions from the obligation to obtain such a consent are limited by the legislator to exceptional situations, i.e., when the delay caused by the procedure for obtaining consent would pose a threat to patient's life, serious injury, or serious health impairment. Undergoing addiction treatment is also voluntary. Exceptions to this principle are stipulated by a legal act. People who abuse alcohol and therefore break down family life, demoralize minors, avoid the obligation to meet the needs of their families, or systematically disturb peace or public order, may be obliged to undergo addiction treatment in an inpatient or outpatient treatment centre on condition that they are addicted to alcohol. A patient who fails to report to the medical entity designated by the court to execute the decision on the obligation to undertake addiction treatment may be brought to this entity by the police. In the context of the obligation to obtain a consent for treatment by a person against whom a court decision containing an obligation in this respect has been issued, there are discrepancies in the application of law provisions. In some medical entities, this results in the forced continuation of addiction treatment by a given patient in hospital, as discharge from the hospital depends on a court order issued in this regard, not on the consent of the patient himself/herself. In other medical entities, patients are not admitted for treatment due to the lack of such a consent, despite the court's obligation in this respect. The article confirms that a specific practice of applying the law, which downgrades the role of the patient's consent in the therapeutic process, has negative consequences for the effectiveness of the therapy.

在波兰的法律体系中,每项医疗程序都需要征得 病人的同意。立法者规定,只有在特殊情况下才可免除征得同意的义务,即征得同意的程序所造成的延误会对病人的生命、严重伤害或严重健康损害构成威胁。接受戒毒治疗也是自愿的。法律规定了这一原则的例外情况。酗酒并因此破坏家庭生活、打击未成年人士气、逃避满足其家庭需求的义务,或蓄意扰乱和平或公共秩序的人,可能必须在住院或门诊治疗中心接受戒酒治疗,条件是他们对酒精上瘾。如果患者没有到法院指定的医疗机构报到,以执行关于承担戒酒治疗义务的决定,警方可将其带到该医疗机构。关于法院已对其做出载有治疗义务的判决的人获得治疗同意的义务,在适用法律规定方面存在差异。在一些医疗机构,这导致病人被迫继续在医院接受戒毒治疗,因为出院取决于法院在这方面签发的命令,而不是病人本人的同意。在其他医疗机构中,尽管法院有这方面的义务,但由于缺乏这种同意,病人无法入院接受治疗。这篇文章证实,降低病人同意在治疗过程中的作用的特定法律适用做法对治疗效果产生了负面影响。
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引用次数: 0
Management of nicotine dependence in patients with psychiatric disorders - recommendations of the Polish Psychiatric Association - part II. 精神病患者的尼古丁依赖管理--波兰精神病学协会的建议--第二部分。
IF 0.9 4区 医学 Q4 PSYCHIATRY Pub Date : 2024-06-30 DOI: 10.12740/PP/OnlineFirst/161774
Marcin Wojnar, Piotr Wierzbiński, Jerzy Samochowiec, Joanna Rymaszewska, Krzysztof J Filipiak, Adam Wichniak, Robert Mróz, Artur Mamcarz, Dominika Dudek

The development of treatment methods for nicotine dependence has progressed slowly because people with psychiatric disorders are usually excluded from participating in clinical trials. There are several therapeutic options to support smoking cessation, including psychological and pharmacological interventions, which should be offered to smokers with mental disorders. The first step in helping tobacco smokers and nicotine-dependent individuals is the assessment of smoking intensity and confirmation of nicotine dependence. Currently, we have several methods of treating nicotine dependence - starting from education and psychotherapy, through pharmacotherapy and replacement therapy, and ending up with obtaining gradual progress with the application of harm reduction. Pharmacological treatment options include nicotine replacement therapy, varenicline or bupropion. The effectiveness of such interventions can be improved by providing anti-smoking therapy under psychiatric treatment and promoting harm reduction as an acceptable initial therapeutic goal. The harm reduction strategy is an approach that should be taken into account individually, particularly in the case of individuals unable to stop smoking, patients with limited insight into their illness, patients experiencing an exacerbation of their illness and persistently uncooperative patients. In this paper, recommendations of the Polish Psychiatric Association on the diagnostics and different treatment methods for nicotine dependence in patients with psychiatric disorders are presented.

由于精神障碍患者通常被排除在临床试验之外,尼古丁依赖治疗方法的研发进展缓慢。有几种支持戒烟的治疗方案,包括心理和药物干预,应提供给有精神障碍的吸烟者。帮助吸烟者和尼古丁依赖者的第一步是评估吸烟强度和确认尼古丁依赖。目前,我们有几种治疗尼古丁依赖的方法--从教育和心理治疗开始,到药物治疗和替代疗法,最后通过应用减低危害的方法来获得渐进的进展。药物治疗包括尼古丁替代疗法、伐尼克兰或安非他明。通过在精神治疗的同时提供禁烟治疗,并将减少危害作为可接受的初始治疗目标,可以提高这些干预措施的有效性。减低伤害策略是一种应个别考虑的方法,特别是对于无法戒烟的患者、对自身疾病了解有限的患者、病情加重的患者以及持续不合作的患者。本文介绍了波兰精神病学协会就精神病患者尼古丁依赖的诊断和不同治疗方法提出的建议。
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引用次数: 0
The rs4354668 polymorphism in the SLC1A2 gene for the EAAT2 glutamate transporter is associated with an increased risk of harmful drug use - an exploratory study on a university student population. EAAT2 谷氨酸转运体 SLC1A2 基因中的 rs4354668 多态性与有害药物使用风险增加有关--一项针对大学生群体的探索性研究。
IF 0.9 4区 医学 Q4 PSYCHIATRY Pub Date : 2024-06-30 DOI: 10.12740/PP/171620
Bartosz Dawidowski, Barbara Olejniczak, Katarzyna Groblińska, Magdalena Knapińska, Urszula Kozicka, Michał Krasiński, Anna Kułak, Grzegorz Grelecki, Zuzanna Czaplińska, Oliwia Piotrowska, Klaudia Kościelecka, Piotr Podwalski, Anna Michalczyk, Jerzy Samochowiec

Objectives: Evidence suggests that decreased dopamine secretion in mesocorticolimbic pathways could predispose to increased susceptibility to substance addiction. It has been proposed to define such a phenomenon as the reward deficit syndrome (RDS). Dopaminergic projections of the reward system receive glutaminergic projections from cortex. Research indicates that a reduction in the stimulating glutamatergic transmission on the dopaminergic system could represent an alternative phenotype of RDS. Potential source of this type of abnormality is glutamate reuptake which depends on excitatory amino acid transport proteins (EAAT) function. The most important of them is EAAT2, polymorphisms of which have been linked to several mental disorders.

Methods: We analyzed the genetic and psychometric data of 125 young adults (n = 125) for the effect of the rs4354668 polymorphism of the SLC1A2 gene for EAAT2 on the risky or harmful drug use (RHDU). After exploratory analysis we used logistic regression models to assess the probability of RHDU in individual groups.

Results: In the final model T/T variant of rs4354668 was significantly associated with a lower probability of RHDU occurrence compared to G/G variant (OR: 0.021; 95% CI: 0.001 - 0.275; p = 0.009). Other significant predictors of RHDU were smoking status and risky or harmful drinking of alcohol.

Conclusions: The results obtained may indicate a possible relationship of the risk of harmful drug use with variants of the rs4354668 polymorphism of the SLC1A2 gene for EAAT2. Subjects with the T/T variant of this polymorphism appear to be less at risk of developing drug use disorders.

研究目的有证据表明,皮质中层边缘通路多巴胺分泌减少可能会导致药物成瘾。有人建议将这种现象定义为奖赏缺失综合征(RDS)。奖赏系统的多巴胺能投射接受来自大脑皮层的谷氨酸能投射。研究表明,对多巴胺能系统的谷氨酸能传导刺激的减少可能是奖赏缺失综合征的另一种表型。这类异常的潜在来源是谷氨酸再摄取,而谷氨酸再摄取取决于兴奋性氨基酸转运蛋白(EAAT)的功能。其中最重要的是 EAAT2,其多态性与多种精神疾病有关:我们分析了 125 名年轻成年人(n = 125)的遗传和心理测量数据,研究 EAAT2 的 SLC1A2 基因 rs4354668 多态性对危险或有害药物使用(RHDU)的影响。经过探索性分析后,我们使用逻辑回归模型评估了各组中出现 RHDU 的概率:在最终模型中,与 G/G 变异相比,rs4354668 的 T/T 变异与较低的 RHDU 发生概率显著相关(OR:0.021;95% CI:0.001 - 0.275;p = 0.009)。其他重要的RHDU预测因素是吸烟状况和危险或有害饮酒:结论:研究结果表明,有害药物使用风险可能与 EAAT2 SLC1A2 基因的 rs4354668 多态性变异有关。具有该多态性 T/T 变体的受试者罹患吸毒障碍的风险似乎较低。
{"title":"The rs4354668 polymorphism in the SLC1A2 gene for the EAAT2 glutamate transporter is associated with an increased risk of harmful drug use - an exploratory study on a university student population.","authors":"Bartosz Dawidowski, Barbara Olejniczak, Katarzyna Groblińska, Magdalena Knapińska, Urszula Kozicka, Michał Krasiński, Anna Kułak, Grzegorz Grelecki, Zuzanna Czaplińska, Oliwia Piotrowska, Klaudia Kościelecka, Piotr Podwalski, Anna Michalczyk, Jerzy Samochowiec","doi":"10.12740/PP/171620","DOIUrl":"https://doi.org/10.12740/PP/171620","url":null,"abstract":"<p><strong>Objectives: </strong>Evidence suggests that decreased dopamine secretion in mesocorticolimbic pathways could predispose to increased susceptibility to substance addiction. It has been proposed to define such a phenomenon as the reward deficit syndrome (RDS). Dopaminergic projections of the reward system receive glutaminergic projections from cortex. Research indicates that a reduction in the stimulating glutamatergic transmission on the dopaminergic system could represent an alternative phenotype of RDS. Potential source of this type of abnormality is glutamate reuptake which depends on excitatory amino acid transport proteins (EAAT) function. The most important of them is EAAT2, polymorphisms of which have been linked to several mental disorders.</p><p><strong>Methods: </strong>We analyzed the genetic and psychometric data of 125 young adults (n = 125) for the effect of the rs4354668 polymorphism of the SLC1A2 gene for EAAT2 on the risky or harmful drug use (RHDU). After exploratory analysis we used logistic regression models to assess the probability of RHDU in individual groups.</p><p><strong>Results: </strong>In the final model T/T variant of rs4354668 was significantly associated with a lower probability of RHDU occurrence compared to G/G variant (OR: 0.021; 95% CI: 0.001 - 0.275; p = 0.009). Other significant predictors of RHDU were smoking status and risky or harmful drinking of alcohol.</p><p><strong>Conclusions: </strong>The results obtained may indicate a possible relationship of the risk of harmful drug use with variants of the rs4354668 polymorphism of the SLC1A2 gene for EAAT2. Subjects with the T/T variant of this polymorphism appear to be less at risk of developing drug use disorders.</p>","PeriodicalId":20863,"journal":{"name":"Psychiatria polska","volume":"58 3","pages":"467-494"},"PeriodicalIF":0.9,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142111399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Psychiatria polska
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