Psychiatria polska最新文献

Objectives: The aim of the study was to assess concentrations of the following neuropeptides: phoenixin, spexin and kisspeptin in venous blood serum of children and adolescents suffering from bipolar disorder, and by this their predictive efficiency in this disorder.

Methods: The study covered 75 individuals with a mean age of 15.26 years (95% CI: 14.86-15.67), of which the study group comprised of 57 individuals diagnosed with bipolar affective disorder and the control group - 18 individuals with no psychiatric diagnosis and no pharmacological treatment. Phoenixin, spexin and kisspeptin levels were determined in the peripheral venous blood serum. Neuropeptide concentrations were measured with the enzyme-linked immunosorbent assay (ELISA).

Results: The mean phoenixin concentration in the studied group equalled 1.57 ng/ml (95% CI: 1.35-1.79), while in the control group - 2.69 ng/ml (95% CI: 2.38-3; U Mann-Whitney test p-value < 0.05). For spexin, these results were 639.65 pg/ml (95% CI: 558.86-720.44) in the studied group, and 354.28 pg/ml (95% CI: 310.33-398.22; U Mann-Whitney test p-value < 0.05) in the control group. The observed differences were statistically significant. The mean concentration of kisspeptin levels in the studied group was 126.02 pg/ml (95% CI: 39.82-212.23; median: 59.85), while in the control group - 54.83 pg/ml (95% CI: 39.23-70.43; median: 51.3; U Mann-Whitney test p-value = 0.29), and the observed difference was not statistically significant.

Conclusions: The occurrence of bipolar disorder symptoms is statistically significantly linked with a decreased phoenixin concentration and to a small degree - with an increased spexin concentration in blood serum of patients. However, it is not linked with the kisspeptin concentration.

No summary.

Objectives: The purpose of the study was to examine the severity of anxiety symptoms and the co-occurrence of anxiety disorders and mood disorders in a group of women in the first year after childbirth participating in the program for the prevention of postpartum depression.

Methods: The study included 1,514 women who were screened by midwives during a patronage visit and were followed up, and 10,454 women who took part in an online screening conducted on the project website. The Edinburgh Postpartum Depression Scale was used for screening, including factor analysis to assess the anxiety subscale, and the GAD-2 questionnaire was used too.

Results: The risk of anxiety disorders was observed in 9.5% of women during the patronage visit and, depending on the survey method, 21.2% (ESDP 3 A) or 13.2% (GAD-2) in the follow-up study up to 9 months postpartum. In the online study, 62.8% of women obtained results indicating a high risk of anxiety disorders. For comparison, the result of 12 points and more indicating the risk of depression was obtained by 6.3% in the first month after childbirth and 14.3% in the follow-up study. The results show that anxiety disorders and mood disorders are significantly related (r = 0.631; p < 0.01).

Conclusions: The risk of having anxiety disorders after childbirth is higher or similar to that of mood disorders. It is warranted to extend screening to anxiety disorders and to develop a rapid pathway of early psychological/psychiatric intervention for women in need.

Objectives: Numerous studies show that a high level of psychopathic traits in youth is related to the propensity to use various types and forms of aggression. The presented study focuses on the relations between psychopathy and aggression, both indirect (relational) and direct in this age group. The triarchic model of psychopathy was used, according to which psychopathy is described as a configuration of boldness, meanness and disinhibition. It was assumed that boldness would be a predictor for indirect aggression and disinhibition - for the direct forms of aggressive behaviors.

Methods: The sample consisted of 200 older adolescents (108 boys and 92 girls), aged 16-19. Two groups were distinguished for comparison: juveniles from youth fostering centers and youth not violating legal norms. For the measurement of the variables the following self-reports were used: Triarchic Psychopathy Measure, Indirect Aggression Scale (Aggressor Version) and Aggression Questionnaire.

Results: From among the dimensions of psychopathy, the strongest predictor for both forms of aggression (indirect and direct) was disinhibition. The study also revealed the differences in the intensity of psychopathic traits and aggressive behaviors with reference to gender and institutionalization. However, the hypothesis on the relationship between boldness and indirect aggression was not confirmed.

Conclusions: The results showed that disinhibition and meanness can be considered as significant personality risk factors for aggressive behaviors and violence not only in adults but also in adolescents. The study supported also the heterogeneity of the triarchic model of psychopathy itself.

Objectives: This study aims to investigate the therapeutic effect of repetitive transcranial magnetic stimulation (rTMS) on the negative symptoms of chronic schizophrenia and serum brainderived neurotrophic factor (BDNF).

Methods: A total of 86 patients with chronic schizophrenia hospitalised from March to October 2019 were randomly assigned to the active rTMS group or the sham rTMS group, with 43 patients in each group. All patients were administered paliperidone orally at a dose of 3-6 mg/d, and rTMS treatment was given to the active rTMS group. The Positive and Negative Syndrome Scale (PANSS) score and the serum BDNF concentration were calculated in both groups at baseline and after two and four weeks of treatment.

Results: There were no statistically significant differences in the PANSS scores and serum BDNF concentrations between the two groups before treatment (p > 0.05). However, after four weeks of treatment, the change in the score on the negative symptom scale in the active rTMS group was greater than in the sham rTMS group (p < 0.05), and the serum BDNF levels in the active rTMS group were higher than in the sham rTMS group (p < 0.05).

Conclusions: Four weeks of continuous rTMS treatment can effectively improve the negative symptoms of schizophrenia, and the serum concentration of BDNF increases as the duration of rTMS treatment increases.

Objectives: The target of the present study was to show the relationship between time and motives for maintaining abstinence and metacognitive beliefs about alcohol and self-conscious emotions.

Methods: Ninety-one alcohol-dependent individuals who are currently maintaining abstinence participated in the study. Three instruments were used to measure individual variables: RALD was used to examine motives for maintaining abstinence, MPA was used to measure the level of individual metacognitive beliefs about alcohol, and SUM 5 was used to measure the level of self-conscious emotions in addicts who maintain abstinence. Correlation analyses were performed and differences in mean ranks of metacognition and self-awareness emotions were examined for the two independent samples.

Results: All metacognitive beliefs were shown to negatively correlate with abstinence time. Some metacognitive beliefs were negatively associated with abstinence motives. Moreover, positive associations of self-conscious emotions and metacognitive beliefs with time and abstinence motives were found. Both metacognitive beliefs and self-conscious emotions have different mean levels depending on the duration of abstinence.

Conclusions: The study revealed that both psychological constructs are related to abstinence maintenance and can be creatively used in further analyses of addiction recovery and relapse prevention.

Vortioxetine is an antidepressant with a unique profile of receptor activity. The pharmacodynamic spectrum of vortioxetine activity is linked to the modulation of not only serotoninergic but also noradrenergic and dopaminergic transmission. At the same time, its pharmacokinetic properties determine good tolerance and safety, which are also observed in elderly patients and those burdened with somatic comorbidity. This work aims to sum up the knowledge coming from the most recent studies assessing the efficacy of vortioxetine. The efficacy of vortioxetine in the treatment of depression was confirmed in a large number of open studies, randomized controlled studies with placebo control, and meta-analyses thereof. What is more, the latest research shows that this drug allows depressed patients to achieve not only symptomatic remission but also an improvement of anhedonia and recovery in cognitive and occupational function. Furthermore, there are studies showing that vortioxetine is efficacious in the treatment of elderly patients, as well as subjects who have experienced trauma or suffer from bipolar depression. Vortioxetine is characterized by a good tolerance profile and safety; rarely does it cause severe adverse effects.

Objectives: The aim of the research was to present the Polish adaptation and validation of the Short Inventory of Problems (SIP-2L) by Miller et al. (1995). The SIP-2L is a popular selfreport measure used to assess the negative consequences of alcohol use in 5 domains with negative consequences: physical, interpersonal, intrapersonal, social and impulse control. The adapted version of SIP assesses lifetime consequences of using alcohol.

Methods: A total of 256 participants diagnosed with alcohol dependence (71 women and 185 men) completed an assessment battery that included SIP-2L and Polish versions of AUDIT, MAST and KOEP-R, which is a modified Polish adaptation of CEAQ - Comprehensive Effects of Alcohol Questionnaire.

Results: Confirmatory factor analysis demonstrated the hypothesized 5-factor model produced the best fit. Reliability of the entire method (Cronbach's α = 0.868) and for all factors was satisfactory, as was convergent validity.

Conclusions: The results support that the Polish version of the SIP-2L has good psychometric properties and can successfully assess the consequences of drinking among patients diagnosed with alcohol dependence.

Objectives: The Covid-19 pandemic changed daily routines and forced people to develop various coping methods. University students were a social group that suffered due to a drastic change in their daily routine. The analysis of adaptation to chronic stress may help in developing more individualized care for people affected by it.

Methods: The examination of coping methods and aggression level was conducted using Brief COPE and STAXI-2 questionnaires on a group of 283 participants, extracted from the initial group of 906 tested students. The study was conducted between the second and the third wave of pandemic in Poland.

Results: The positive coping methods were dominant among the examined group. The most used were active coping, use of informational support and planning. The negative coping methods were inextricably linked to a higher aggression level, and were more prevailing in the female students.

Conclusions: The first symptoms of maladaptive behaviors may be hidden in presumably usual activities and attitudes. It is important to be aware of them in order to provide support for students and other social groups affected by chronic stress.

The study aims to present a case of atypical poisoning with lithium carbonate in a 57-year-old woman treated for bipolar affective disorder with lithium carbonate for about 30 years. The patient was admitted to the hospital with significant agitation. An important finding obtained from the family interview was the patient's significant weight loss over the past year. In the hospital, the patient received haloperidol and clonazepam. Laboratory tests showed a very high blood lithium concentration of 3.79 mmol/l [N: 0.6─1.2 mmol/l] and elevated serum concentrations of creatinine (3.6 mg/dl) and urea (110 mg/dl). The patient was transferred to the toxicology department, where hemodialysis was performed and intensive treatment initiated. Despite the rapid decrease in lithium levels, her condition gradually deteriorated. The patient died on the fifth day of hospitalization. The autopsy revealed polycystic kidney disease (PKD). During the preparation of the medico-legal report on the correctness of the medical treatment, it was assumed that the cause of death was lithium carbonate poisoning in the course of advanced chronic kidney disease due to PKD, probably a consequence of long-term lithium therapy. The analysis of medical records revealed that despite her psychiatrist's recommendation, the patient had been refusing the monitoring of lithium levels for the past 18 years. This case demonstrates that both psychiatrists and toxicologists should be aware of possible lithium poisoning upon the deterioration of renal function. Therefore, assessment of renal function should be an integral part of monitoring lithium therapy.