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Coronary No-reflow Phenomenon: A Review of Therapeutic Pharmacological Agents 冠状动脉无血流现象:治疗药物综述
Pub Date : 2020-10-01 DOI: 10.30483/RIJM.2020.254145.1002
Bahram Shahri, M. Vojdanparast
Coronary no-reflow phenomenon (CNRP) is one of the leading catastrophic consequences of percutaneous coronary intervention (PCI). Although several preventive strategies have been advised, yet CNRP is not entirely controlled with pharmacological agents after diagnosis. This study is a review of therapeutic pharmacological agents used in various studies for post-PCI-CNRP. Several pharmacological agents have been introduced for reducing the burden of adverse outcome, before or during PCI. Although most of these agents have shown a remarkable effect on post-PCI CNRP incidence reduction, and it seems more powerful are still needed for a better validation of the results. It appears that intra lesion and distal intracoronary administrations would have a less systemic effect, and therefore may be safer than catheter injection. Moreover, adenosine, sodium nitroprusside, and calcium channel blockers are among the most routinely used methods. However, we believe that the best approach in treating or preventing no-reflow post-STMI might be combinational therapy. By the way, although there have been numerous studies on different agents capable of lessening the noreflow phenomenon, yet there is no exact guideline for choosing the most appropriate drug. A systematic review and meta-analysis on all available or practiced combinational pharmacotherapies to prevent PCI-related no-reflow are needed to suggest the most appropriate therapy.
冠状动脉无回流现象(CNRP)是经皮冠状动脉介入治疗(PCI)的主要灾难性后果之一。尽管已经提出了几种预防策略,但在诊断后,药物并不能完全控制CNRP。本研究综述了PCI后CNRP的各种研究中使用的治疗药物。在PCI之前或期间,已经引入了几种药物来减轻不良结果的负担。尽管这些药物中的大多数对PCI后CNRP发病率的降低显示出显著的效果,但似乎仍需要更强大的药物来更好地验证结果。病变内和远端冠状动脉内给药对全身的影响较小,因此可能比导管注射更安全。此外,腺苷、硝普钠和钙通道阻滞剂是最常用的方法。然而,我们认为治疗或预防STMI后无再流的最佳方法可能是联合治疗。顺便说一句,尽管已经有许多关于能够减轻去甲流现象的不同药物的研究,但还没有选择最合适药物的确切指南。需要对所有可用或实践的联合药物治疗进行系统综述和荟萃分析,以防止PCI相关的无再流,从而提出最合适的治疗方法。
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引用次数: 0
The Effect of Distress Tolerance and Emotional Self-Regulation on Complicated Grief with the Mediating Role of Social Support in Survivors of Kermanshah Earthquake 克尔曼沙地震幸存者痛苦容忍和情绪自我调节对复杂悲伤的影响及社会支持的中介作用
Pub Date : 2020-10-01 DOI: 10.30483/RIJM.2020.254152.1007
A. Daneshvar, M. Madahi, H. Ahadi
Background: Bereavement is a person's response to loss that has a physical, psychological, or social aspect. Objectives: This study aimed to determine the effect of distress tolerance and emotional self-regulation on complicated grief with the mediating role of social support. Methods: The research method was descriptive and the research design was a structural equation modeling. The statistical population consisted of all survivors of the Kermanshah earthquake who are suffering from complicated grief in 2019 and are selected by convenience sampling method. Data obtained by Grief Experience Questionnaire (GEQ), Social Support Scale (MOS-SSS), Emotional self-regulation questionnaire and Distress Tolerance Questionnaire. Data were analyzed by the Pearson correlation coefficient and structural equation modeling using SPSS.22 and PLS2-SMART software. Results: The results of this study showed that the relationship between the variables of the study was significant, and distress tolerance, self-regulation, and social support have the ability to predict complicated grief (p <0.001). Also, social support has the mediating variable between distress tolerance and emotional self-regulation on complicated grief (p <0.001). Conclusion: According to the results of this study, earthquake survivors should be able to control the tolerance of grief after the earthquake by increasing their distress tolerance and emotional self-regulation and with social support from others.
背景:丧亲之痛是一个人对损失的反应,它具有生理、心理或社会方面的影响。目的:本研究旨在探讨痛苦容忍和情绪自我调节在社会支持的中介作用下对复杂悲伤的影响。方法:采用描述性研究方法,研究设计为结构方程模型。统计人群是2019年克尔曼沙地震中遭受复杂悲伤的所有幸存者,采用方便抽样法选择。数据由悲伤体验问卷(GEQ)、社会支持量表(MOS-SSS)、情绪自我调节问卷和痛苦容忍问卷获取。采用SPSS.22和PLS2-SMART软件对数据进行Pearson相关系数分析和结构方程建模。结果:本研究结果显示,本研究变量之间的关系显著,痛苦容忍、自我调节和社会支持有预测复杂悲伤的能力(p <0.001)。社会支持在复杂悲伤的痛苦容忍和情绪自我调节之间起中介作用(p <0.001)。结论:根据本研究的结果,地震幸存者应该能够通过增加他们的痛苦容忍和情绪自我调节,并得到他人的社会支持来控制震后的悲伤容忍。
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引用次数: 0
Effectiveness of Behavioral-Cognitive Therapy on Sexual Self-Esteem and Marital Commitment of Couples' with Troubled Relationships 行为认知疗法对问题夫妻性自尊和婚姻承诺的影响
Pub Date : 2020-10-01 DOI: 10.30483/RIJM.2020.254172.1025
Alireza Khataei
Background: Health in families is rooted in sustenance and health of relationships between husbands and wives; and marital relationship is the core of families, disorders of which are threats to family survival. Objectives: The present study was aimed to examine the effectiveness of CBT on sexual self-esteem and marital commitment of couples' with troubled relationships in Tehran in 2017.Material and Methods: It was semi-experimental with a pre-test, post-test design as well as an experiment and a control group. The statistical population of the present research consisted of all couples with troubled relationships in Tehran, who were selected using a convenience sampling method and Cohen table for the sample size , and they were randomly divided into two groups: an experiment group (15 individuals) and a control group (15 individuals).The experiment group received ten 90-minute sessions of group CBT interventions, and the control group remained on a waitlist. The measurement tools of the research included Dobel Naha and Schwarz's sexual self-esteem questionnaire and Adams and Jones' marital commitment questionnaire. The analysis of the data obtained from implementing the questionnaires was done through SPSS-V22 software in two sections: descriptive and inferential . Results showed that CBT leads to an increase in sexual self-esteem in couples with troubled relationships. Therefore, it can be stated that group CBT is an effective method for improving self-esteem and marital commitment in couples. Conclusion: It can be stated that CBT helps family members to face problems effectively by resolving conflicts among family members and improving interpersonal relationships
背景:家庭健康的根源在于丈夫和妻子之间关系的维持和健康;而婚姻关系是家庭的核心,婚姻关系的失调是家庭生存的威胁。目的:本研究旨在探讨认知行为疗法(CBT)对德黑兰2017年有问题夫妻性自尊和婚姻承诺的影响。材料与方法:采用前测、后测、试验组和对照组的半实验设计。本研究的统计人群为德黑兰地区所有关系有问题的夫妻,样本量采用方便抽样法,采用Cohen表法,随机分为实验组(15人)和对照组(15人)。实验组接受了10次90分钟的集体认知行为治疗干预,而对照组仍在等待名单上。本研究的测量工具包括Dobel Naha and Schwarz的性自尊问卷和Adams and Jones的婚姻承诺问卷。通过SPSS-V22软件对实施问卷所获得的数据进行分析,分为描述性和推断性两部分。结果表明,认知行为疗法可以提高夫妻关系不稳定的性自尊。因此,可以认为团体CBT是提高夫妻自尊和婚姻承诺的有效方法。结论:CBT可以通过解决家庭成员之间的冲突和改善人际关系来帮助家庭成员有效地面对问题
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引用次数: 1
Evaluation of How to Use Warfarin after Heart Valves Replacement Operations 心脏瓣膜置换术后华法林的应用评价
Pub Date : 2020-10-01 DOI: 10.30483/RIJM.2020.254164.1018
Kambiz Alizadeh, M. Tabari, M. Sakhaei, Jamil Esfehanizadeh, Z. Tabrizi, A. Izanloo
Introduction Implantation of prosthetic valve requires a life time consumption of anticoagulation. Thrombotic and embolism complications as well as bleeding associated with anticoagulants are the leading cause of mortality and morbidity after heart valve surgery. Accordingly, this study is designed to explore and report the complications and factors related to usage of warfarin and constant check of prothrombin time and international normalized ratio. Method: This is an observational study in which the medical records of 100 patients with an average age of 47.9 ± 13.4 years undergoing surgery for replacement of heart valves were studied. All factors related to mortality and postoperative complications were extracted, and the patients were followed up for one year. Results: The results suggested that tricuspid valve insufficiency was significantly correlated other valvular defects. Nine patients died; one patient in the operating room, one patient in the ICU, one patient in the ward and six patients during the first year died after the surgery. Two of the patients needed redo-surgery in the first year. It should be noted that among patients receiving warfarin on a regular basis (n=81), no mortality was reported in a one-year fallow-up. Conclusion: In this study, out- of-hospital mortality only occurred in patients' irregular usage of warfarin and without follow-up coagulation tests. So, we conclude that in developing country, if we cannot follow and train the patients constantly for warfarin usage and blood tests, mechanical valve utilization would be concomitant with high risk complications.
引言人工瓣膜的植入需要终生消耗抗凝药物。血栓和栓塞并发症以及与抗凝血剂相关的出血是心脏瓣膜手术后死亡和发病率的主要原因。因此,本研究旨在探讨和报告与华法林的使用、凝血酶原时间和国际标准化比率的持续检查有关的并发症和因素。方法:这是一项观察性研究,研究了100名平均年龄为47.9±13.4岁的心脏瓣膜置换手术患者的病历。提取了所有与死亡率和术后并发症相关的因素,并对患者进行了一年的随访。结果:提示三尖瓣功能不全与其他瓣膜缺损存在显著相关性。9名患者死亡;手术室的一名患者、重症监护室的一位患者、病房的一位病人和第一年的六位病人在手术后死亡。其中两名患者在第一年需要再次手术。值得注意的是,在定期接受华法林治疗的患者中(n=81),一年内没有死亡报告。结论:在本研究中,院外死亡率仅发生在患者不规则使用华法林且无后续凝血测试的情况下。因此,我们得出的结论是,在发展中国家,如果我们不能持续跟踪和培训患者使用华法林和血液测试,机械瓣膜的使用将伴随着高风险并发症。
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引用次数: 0
Analysis of Biological Stress Indices in Patients with Gastrointestinal Cancer Based on Perceived Stress Mediated by Rumination using Structural Equation Modeling 基于反刍感知应激介导的胃肠道肿瘤患者生物应激指标分析
Pub Date : 2020-10-01 DOI: 10.30483/RIJM.2020.254149.1004
Saeed Hashemzadeh, Mahmoud Borjali, Peyman Hassani Abharian
Background: Considering the prevalence of this disease and the high mortality rate of gastric cancer in the country, it is necessary to investigate the causes and factors affecting this disease's incidence. Objective: This study aimed to analyze the structural equations of biological stress indices in patients with gastrointestinal cancer based on perceived stress mediated by rumination. Methods: This research was a descriptive-correlational study of structural equation modeling. The statistical population of this study included all patients with gastrointestinal cancer referred to Reza-Mashhad hospital and Avicenna Hospital in Tehran in 2020, of which 250 patients were selected by convenience sampling method. Data were collected using the perceived stress scale (PSS), Nolen and Hoxma rumination questionnaire, and biological stress indices. Data were analyzed using structural equation modeling and Pearson correlation statistical methods using SPSS.22 and AMOS.22 software. Results: The results showed that perceived stress (β=0.45, P0>0.001) directly affected rumination. Also, rumination (β=0.30, P=0.001) had a direct effect on biological stress indices. Rumination played a mediating role in the relationship between perceived stress and biological stress indices (RMSEA: 0.001; AGFI: 0.93). Conclusion: Considering that perceived stress and rumination are effective on biological stress of gastrointestinal patients, it is necessary for therapists to pay attention to modifying beliefs related to stress and rumination in the psychological health of gastrointestinal patients in order to improve the quality of life of patients.
背景:考虑到该病在我国的流行和癌症的高死亡率,有必要对其发病原因和影响因素进行调查。目的:本研究旨在分析癌症胃肠道患者基于反刍介导的感知应激的生物应激指数结构方程。方法:本研究为结构方程建模的描述性相关研究。本研究的统计人群包括2020年转诊至德黑兰Reza-Mashhad医院和Avicenna医院的所有胃肠道癌症患者,其中250名患者采用方便抽样方法。使用感知压力量表(PSS)、Nolen和Hoxma沉思问卷以及生物压力指数收集数据。使用SPSS.22和AMOS.22软件,使用结构方程建模和Pearson相关统计方法对数据进行分析。结果:感知应激(β=0.45,P0>0.001)直接影响反刍。反刍(β=0.30,P=0.001)对生物应激指数也有直接影响。反刍在感知应激和生物应激指数之间的关系中起着中介作用(RMSEA:0.001;AGFI:0.93)。结论:考虑到感知应激和反刍对胃肠道患者的生物应激有效,治疗师有必要注意改变胃肠道患者心理健康中与压力和沉思有关的信念,以提高患者的生活质量。
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引用次数: 0
Morphometric Characteristics of 1200 Normal Kidneys in Cadavers at the Mashhad Forensic Medicine Center 马什哈德法医中心1200具尸体正常肾脏的形态计量学特征
Pub Date : 2018-10-01 DOI: 10.30483/RIJM.2018.34
M. Rezazadeh, M. Mohammadi, Maryam Sajjadian, Farhad Moghimian, S. Mohammadi, A. Hedjazi
Background: Kidneys play an important role in excertion of bodily waste and the regulation of water and electrolyte. Currently available sources and books are based on anthropometric characteristics from Western countries. Determining national anthropometric measurements is a research priority in Iran. Based on a recent search, no study has been done on the standard data of kidneys in the Iranian population. Objectives: The present study investigated the morphometrical characteristics of the kidney (length, width, thickness, index, and weight) in an Iranian population. Methods: This cross-sectional study was performed on 604 cadavers (122 females/482 males) with a mean age of 43.86 ± 19.09 years in Mashhad Forensic Medicine Center in 2015. After approval of the Ethical Committee, demographic characterizes of cadavers were recorded. Then, length, width, thickness, index and weight of kidney were measured using a vernier caliber. At the end, data were analyzed using SPSS software. Results: Themean length of the kidney was 11.12 ± 1.73 cm, mean width was 5.09 ± 2.19 cm, mean thickness was 2.60 ± 1.39 cm, kidney index was 2.33 ± 1.62, and mean weight was 143.03 ± 52.97 g. No significant difference was seen in the morphometric values of the kidney between males and females (P>0.05), but a significant correlation was found between the age and body surface area of the cadavers and the length, width, thickness, index, and weight of the studied kidneys (P
背景:肾脏在身体排泄物的分配以及水和电解质的调节方面发挥着重要作用。目前可获得的资料和书籍都是基于西方国家的人体测量特征。确定国家人体测量是伊朗的研究重点。根据最近的搜索,还没有对伊朗人口的肾脏标准数据进行研究。目的:本研究调查了伊朗人群肾脏的形态计量特征(长度、宽度、厚度、指数和重量)。方法:本横断面研究于2015年在马什哈德法医中心对604具尸体(122名女性/482名男性)进行,平均年龄43.86±19.09岁。在伦理委员会批准后,对尸体的人口特征进行了记录。然后用游标卡尺测量肾脏的长度、宽度、厚度、指数和重量。最后,利用SPSS软件对数据进行分析。结果:肾的平均长度为11.12±1.73cm,平均宽度为5.09±2.19cm,平均厚度为2.60±1.39cm,肾指数为2.33±1.62,平均重量为143.03±52.97g,但年龄、体表面积与肾脏的长、宽、厚、指数、重量有显著相关性(P
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引用次数: 0
Identifying Pattern of Relationships between Attachment Styles, Life Satisfaction and Perfectionism in University Students 大学生依恋类型、生活满意度和完美主义关系的识别模式
Pub Date : 2018-02-27 DOI: 10.5812/rijm.13060
Marjan Pouravari, M. Behboodi, Asghar Sharifi
Background: Life satisfaction is a subjective and unique concept to every human being which constitutes an essential component of subjective well-being. Objectives: The purpose of the present study was identifying the pattern of relationship between attachment styles, life satisfaction and perfectionism in university students. Methods: The statistical society included all students of Azad university of Roodehen who were studying at this university in 2014 15 academic year. The sample size was 271 undergraduate students who were selected by stratification random sampling from all faculties except faculty of education and counseling and also Psychology. The data were collected using life satisfaction scale, collins and reid’s adult attachment styles and terry and short’s positive and negative perfectionism scale. Results: The findings showed that positive and negative perfectionism variables influence on explanation of life satisfaction changes. Anxious attachment through negative perfectionism influences directly and indirectly on explanation of life satisfaction changes. Also avoidant attachment through positive and negative perfectionism influences directly and indirectly on explanation of life satisfaction changes. However, secure attachment neither directly nor indirectly influences on explanation of life satisfaction changes. Conclusions: The results of this study have several important implications for counselors who work with perfectionism. Counselors should consider perfectionism as a multidimensional construct with both healthy and unhealthy dimensions rather than as only problematic construct.
背景:生活满意度是每个人的主观和独特的概念,是主观幸福感的重要组成部分。目的:探讨大学生依恋类型、生活满意度和完美主义三者之间的关系模式。方法:统计学会纳入2014 - 2015学年在鲁德亨阿扎德大学就读的所有学生。本研究样本量为271名本科生,采用分层随机抽样的方法从除教育与咨询学院和心理学学院外的所有院系中抽取。采用生活满意度量表、collins和reid的成人依恋类型量表和terry和short的积极和消极完美主义量表收集数据。结果:积极和消极完美主义变量对生活满意度变化的解释有影响。焦虑依恋通过消极完美主义直接或间接影响生活满意度变化的解释。回避依恋通过积极完美主义和消极完美主义直接或间接地影响生活满意度变化的解释。然而,安全依恋对生活满意度变化的解释既没有直接影响,也没有间接影响。结论:本研究的结果对从事完美主义工作的咨询师有几个重要的启示。心理咨询师应该把完美主义看作是一个多维度的结构,有健康和不健康的维度,而不仅仅是一个有问题的结构。
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引用次数: 2
Investigation of Self-Esteem in High School Students with Premenstrual Syndrome 高中月经前期综合征学生自尊状况调查
Pub Date : 2018-02-24 DOI: 10.5812/RIJM.12249
F. Ghodrati, M. Dehghani, P. Tavakoli, M. Akbarzadeh
Background: Premenstrual syndrome (PMS) is one of the most common disorders of reproductive age, and it is reported that 90% 85% of the people are suffering from this disorder. Among the multiple symptoms of mental premenstrual syndrome, dysphoria, irritability, tension, anxiety and physical symptoms of bloating and breast pain are more common symptoms that can interfere with personal, family and community relationships. Objectives: This study aimed to evaluate the frequency of the symptoms of PMS (physical, psychological and social) and the level of self-esteem in girls with PMS in 2013. Methods: A cross-sectional study was performed on 200 girl high-school students of Shiraz city who had PMS. The study tools included demographic questionnaire, premenstrual symptoms, screening tool (PSST), (completed in two consecutive months) and Cooper Smith questionnaire. Data was analyzed by applying SPSS (version 16) and descriptive statistics. Results: The mean age of the study population was 16.34 ± 1.06. About 50.5 percent were within 14-16 years old. 11.43 ± 3.89, 12.87 ± 4.49, and 39.28 ± 16.2 were the mean scores of physical, mental and total symptoms in girls with PMS, respectively. Moderate and high levels of self-esteem were reported 53% and 47% respectively among the patients with PMS. Conclusions: The results showed that high self-esteem is decreased in patients with premenstrual syndrome. Due to the mood disorders, the subjects may avoid their perfection tendency and intensify their negative self-concept leading to low self-esteem. Different treatments, particularly psychological remedies, are required for those suffering from PMS.
背景:经前综合征(PMS)是育龄期最常见的疾病之一,据报道90% ~ 85%的人患有该疾病。在精神经前综合征的多种症状中,烦躁不安、易怒、紧张、焦虑以及腹胀和乳房疼痛等身体症状是更常见的症状,可能会干扰个人、家庭和社区关系。目的:本研究旨在评估2013年经前症候群女孩生理、心理和社会症状的发生频率及自尊水平。方法:对设拉子市200名经前症候群女生进行横断面调查。研究工具包括人口统计问卷、经前症状筛查工具(PSST)(连续两个月完成)和Cooper Smith问卷。数据分析采用SPSS (version 16)和描述性统计。结果:研究人群平均年龄为16.34±1.06岁。大约50.5%的学生年龄在14-16岁之间。经前综合症女生生理、精神、总症状的平均得分分别为11.43±3.89、12.87±4.49、39.28±16.2。经前症候群患者中有中度自尊和高度自尊的比例分别为53%和47%。结论:经前综合征患者的高自尊水平有所下降。由于情绪障碍,被试可能会回避他们的完美倾向,强化他们的消极自我概念,导致低自尊。经前症候群患者需要不同的治疗方法,尤其是心理疗法。
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引用次数: 4
Health Literacy and Health Inequity in the Community Medicine Specialists Point of View 社区医学专家的健康素养与健康不公平
Pub Date : 2018-02-12 DOI: 10.5812/RIJM.58404
M. Dadgarmoghaddam, S. Niroumand
Health Literacy and Health Inequity in the Community Medicine Specialists Point of View Maliheh Dadgarmoghaddam, and Shabnam Niroumand Assistant Professor of Community Medicine, Departments of Community Medicine, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, IR Iran Assistant Professor of Community Medicine, Department of Educational Development, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, IR Iran Corresponding author: Shabnam Niroumand, Assistant Professor of Community Medicine, Department of educational Development, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, IR Iran. Tel: +98-9153036693, Fax: +98-3882860, E-mail: shabnamniroomand@yahoo.com
社区医学专家的健康素养和健康不平等观点Maliheh Dadgarmoghaddam和Shabnam Niroumand社区医学助理教授,马什哈德医学院社区医学系,伊朗马什哈德医科大学通讯作者:Shabnam Niroumand,伊朗马什哈德马什哈德医学院教育发展系社区医学助理教授。电话:+98-9153036693,传真:+98-3882860,电子邮件:shabnamniroomand@yahoo.com
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引用次数: 0
Assessment the of Amplification HER-2/neu Gene by Chromogenic In Situ Hybridization (CISH) Compared to Immunohistochemistry (IHC) Method in Gastric Cancer 显色原位杂交(CISH)与免疫组化(IHC)方法扩增癌症HER-2/neu基因的比较
Pub Date : 2018-02-10 DOI: 10.5812/RIJM.13397
S. Amoueian, A. Attaranzadeh, Mahdi Montazer, Arash Akhavan Rezayat, Amir Behforouz, Fatemeh Sobhani
Background: Gastric cancer has a high mortality rate and often has a poor treatment outcome. The HER2/neu gene target therapy has been known as a potential way for treatment. Objectives: The goal of our study was assessment the relation between chromogenic in situ hybridization (CISH) and immunohistochemistry (IHC) methods in determining the best diagnostic method for gastric cancer. Methods: In this historical cohort study, 50 gastric cancer samples were analyzed by CISH and IHC. The relation between clinical-pathological parameters of HER2/neu was also analyzed. Alive patients were followed from 2009 through 2012 for the main out-comes (mortality). The results of these two methods, in terms of sex, age, tumor size, grading, staging, tumor location, metaplasia, presence of necrosis and ulceration, vascular invasion, the TNM system, mucin or signet producing adenocarcinoma cells and patient survival rates were compared. Results: There was no significant difference between IHC and CISH regarding the sex, age, tumor size, grading, staging, tumor location, metaplasia, presence of necrosis and ulceration, vascular invasion, the TNM system, mucin or signet producing adenocarci-nomacellsandpatientsurvivalrates. Comparisonof TNMscoresbythesetwomethodsshowednosignificantrelationshipbetween IHC and staging, but a statistically significant difference between CISH and different N staging, (P < 0.05) was assessed. Conclusions: Comparison between IHC and CISH showed the only significant relationship between CISH and different N staging. Therefore, low amplified CISH was a better diagnostic method for gastric cancer, compared to low expression in IHC.
背景:癌症死亡率高,治疗效果差。HER2/neu基因靶向治疗已被认为是一种潜在的治疗方法。目的:本研究旨在评估显色原位杂交(CISH)和免疫组织化学(IHC)方法之间的关系,以确定癌症的最佳诊断方法。方法:在这项历史性队列研究中,用CISH和IHC对50例癌症样本进行分析。并分析HER2/neu的临床病理参数之间的关系。从2009年到2012年,对存活患者的主要转归(死亡率)进行了随访。比较这两种方法在性别、年龄、肿瘤大小、分级、分期、肿瘤位置、化生、坏死和溃疡的存在、血管侵袭、TNM系统、产生粘蛋白或印戒的腺癌细胞和患者生存率方面的结果。结果:IHC和CISH在性别、年龄、肿瘤大小、分级、分期、肿瘤位置、化生、坏死和溃疡、血管侵袭、TNM系统、产生粘蛋白或印戒的腺癌细胞和患者生存率方面没有显著差异。两种方法对TNMs评分的比较表明,IHC和分期之间没有明显的相关性,但评估了CISH和不同N分期之间的统计学显著差异(P<0.05)。结论:IHC和CISH之间的比较表明,CISH与不同的N分期之间只有显著的关系。因此,与IHC中的低表达相比,低扩增CISH是癌症更好的诊断方法。
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引用次数: 0
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Razavi International Journal of Medicine
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