L. Shirzadeh, Samira Nasrfard, N. Abdollahpour, G. Khademi, M. Sezavar
Background: The purpose of this study is to determine the frequency of hyperglycemia in nondiabetic critically ill children and to investigate its relationship with mechanical ventilation, length of stay and mortality. Methods: In this original retrospective study, data was (were) collected between 2013 and 2014 from the pediatric intensive care unit data base of Sheikh’s Children Hospital in Mashhad, Iran (one hundred admitted children). Results: From among 97 subjects, 49 subjects (50.5%) were hospitalized for more than 10 days, and the mean length of stay was 14 days. The overall mortality rate was 16 subjects (16.5%) and frequency of hyperglycemia was 24 subjects (24.7%). The median for blood glucose measurements was 100 mg/dl. Seventy three subjects (75.3%) had a mean blood glucose level in the normal range. Overall, 18 subjects (18.6%) had at least one blood glucose measurement of 180 mg/dL or higher. There was a significant association between hyperglycemia and mortality (P < 0.001). Linear regression analysis showed positive correlation between blood glucose level, length of stay and length of ventilation (P ≤ 0.001). The maximum serum glucose concentration positively correlated with duration of mechanical ventilation and length of stay (P < 0.001). Conclusions: Our study found that maximum serum glucose concentration positively correlated with the duration of mechanical ventilation, length of stay, and mortality.
{"title":"Investigation of the Relation Between Hyperglycemia and Morbidity and Mortality Rates in Critically Ill Children in March 2013 to February 2014","authors":"L. Shirzadeh, Samira Nasrfard, N. Abdollahpour, G. Khademi, M. Sezavar","doi":"10.17795/RIJM40340","DOIUrl":"https://doi.org/10.17795/RIJM40340","url":null,"abstract":"Background: The purpose of this study is to determine the frequency of hyperglycemia in nondiabetic critically ill children and to investigate its relationship with mechanical ventilation, length of stay and mortality. Methods: In this original retrospective study, data was (were) collected between 2013 and 2014 from the pediatric intensive care unit data base of Sheikh’s Children Hospital in Mashhad, Iran (one hundred admitted children). Results: From among 97 subjects, 49 subjects (50.5%) were hospitalized for more than 10 days, and the mean length of stay was 14 days. The overall mortality rate was 16 subjects (16.5%) and frequency of hyperglycemia was 24 subjects (24.7%). The median for blood glucose measurements was 100 mg/dl. Seventy three subjects (75.3%) had a mean blood glucose level in the normal range. Overall, 18 subjects (18.6%) had at least one blood glucose measurement of 180 mg/dL or higher. There was a significant association between hyperglycemia and mortality (P < 0.001). Linear regression analysis showed positive correlation between blood glucose level, length of stay and length of ventilation (P ≤ 0.001). The maximum serum glucose concentration positively correlated with duration of mechanical ventilation and length of stay (P < 0.001). Conclusions: Our study found that maximum serum glucose concentration positively correlated with the duration of mechanical ventilation, length of stay, and mortality.","PeriodicalId":20994,"journal":{"name":"Razavi International Journal of Medicine","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67422843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fullerenol Nanoparticles Decrease Brain Infarction Through Potentiation of Superoxide Dismutase Activity During Cerebral Ischemia-Reperfusion Injury","authors":"Shamsi Darabi, M. Mohammadi, Zeinab Sadat Sobhani","doi":"10.17795/RIJM41736","DOIUrl":"https://doi.org/10.17795/RIJM41736","url":null,"abstract":"","PeriodicalId":20994,"journal":{"name":"Razavi International Journal of Medicine","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67422445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Reza Mehrandish, A. Mellati, A. Rahimipour, N. Nayeri
Background: Breast cancer is the most prevalent cancer and the second cause of death among women around the world. In many cancers, including breast cancer, Fatty acid synthase (FASN) gene expression is increased significantly. In breast cancer cell lines, expression of FASN is higher in HER2 positive cell line like SKBR3 than the others. FASN is the key enzyme for fatty acid synthesis de novo pathway and it is producing palmitate which is necessary for cell membrane formation. Cichorium intybus is a medicinal plant that effectively leads to inhibition of fatty acid synthase and thus reduces the percentage of survival of cancer cell lines. Objectives: The aim of this study was to evaluate the effect of methanol extract of Chicorium intybus root on percentage of survival in SKBR3 cell line. Methods: Human breast cancer SKBR3 cell line was cultured in DMEM medium. Methanol extract of Cichorium intybus root was extracted and different dilutions (200, 300, 400, 500 and 600μg/mL) were added to cell culture. Cell viability was quantitated by MTT assay after 24, 48 and 72 hours. Results: Cichorium intybus could decrease cell viability. The effects of extract on cell viability were observed after 24, 48 and 72 hours on SKBR3 cell line and IC50 was 800, 400 and 300 after 24, 48 and 72 hours of treatment, respectively. Conclusions: Our study shows that methanol extract of Cichorium intybus has cytotoxic effects on tumor cells. This is a pilot work for further evaluation in the future.
{"title":"Anti-Cancer Activity of Methanol Extracts of Cichorium Intybus on Human Breast Cancer SKBR3 Cell Line","authors":"Reza Mehrandish, A. Mellati, A. Rahimipour, N. Nayeri","doi":"10.5812/RIJM.38369","DOIUrl":"https://doi.org/10.5812/RIJM.38369","url":null,"abstract":"Background: Breast cancer is the most prevalent cancer and the second cause of death among women around the world. In many cancers, including breast cancer, Fatty acid synthase (FASN) gene expression is increased significantly. In breast cancer cell lines, expression of FASN is higher in HER2 positive cell line like SKBR3 than the others. FASN is the key enzyme for fatty acid synthesis de novo pathway and it is producing palmitate which is necessary for cell membrane formation. Cichorium intybus is a medicinal plant that effectively leads to inhibition of fatty acid synthase and thus reduces the percentage of survival of cancer cell lines. Objectives: The aim of this study was to evaluate the effect of methanol extract of Chicorium intybus root on percentage of survival in SKBR3 cell line. Methods: Human breast cancer SKBR3 cell line was cultured in DMEM medium. Methanol extract of Cichorium intybus root was extracted and different dilutions (200, 300, 400, 500 and 600μg/mL) were added to cell culture. Cell viability was quantitated by MTT assay after 24, 48 and 72 hours. Results: Cichorium intybus could decrease cell viability. The effects of extract on cell viability were observed after 24, 48 and 72 hours on SKBR3 cell line and IC50 was 800, 400 and 300 after 24, 48 and 72 hours of treatment, respectively. Conclusions: Our study shows that methanol extract of Cichorium intybus has cytotoxic effects on tumor cells. This is a pilot work for further evaluation in the future.","PeriodicalId":20994,"journal":{"name":"Razavi International Journal of Medicine","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71296979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Arjmand, M. Ghayour-Mobarhan, F. Tara, H. Ashraf, D. H. Alamdari
Background: Nursing is a very stressful occupation, particularly when associated with changing shift working that may result in oxidative stress. Oxidative Stress is created by a misbalance between pro-oxidants and antioxidants towards pro-oxidants. Damage to lipids, protein, DNA, growth and cell function is obtained as result of oxidant. OS has been played an important role in many of diseases. In this study, we assessed the potential for OS by determining the pro-oxidant-antioxidant balance assay (PAB assay) in nurses who worked variable shift patterns; compared with nurses only working day shifts and a non-nurse control group. Methods: Sera of 44 nurses with rotating shift working (night and day) and 43 nurses working day shift only and 80 healthy subjects, who did not work shifts and were not nurses, were collected and serum PAB was measured. Results: A significant higher serum PAB value was observed in shift working and daytime nurses (152.28± 43.64 HK) in comparison to the control group (63.64 ± 34.41 HK index), P Value = 0.001. In day time nurses, also serum PAB between male (119.09 ± 47.14 HK) and female (162.53 ± 37.02 HK) in nursing workers was significant, P Value = 0.005. In the night shift working nurses, there was also a significant difference of PAB value between male (129.89 ± 35.76 HK) and female (170.46 ± 44.47 HK), P value = 0.002. Serum PAB between night shift workers (151.10± 45.02 HK) and daytime nurses (153.44± 42.66 HK) was no significant. A significant relationship was observed between serum PAB value and gender in nurses. There was no significant correlation between age and
{"title":"Serum Pro-oxidant-Antioxidant Balance Assay in Nurses who Working Day and Rotating Night Shift","authors":"M. Arjmand, M. Ghayour-Mobarhan, F. Tara, H. Ashraf, D. H. Alamdari","doi":"10.17795/RIJM40383","DOIUrl":"https://doi.org/10.17795/RIJM40383","url":null,"abstract":"Background: Nursing is a very stressful occupation, particularly when associated with changing shift working that may result in oxidative stress. Oxidative Stress is created by a misbalance between pro-oxidants and antioxidants towards pro-oxidants. Damage to lipids, protein, DNA, growth and cell function is obtained as result of oxidant. OS has been played an important role in many of diseases. In this study, we assessed the potential for OS by determining the pro-oxidant-antioxidant balance assay (PAB assay) in nurses who worked variable shift patterns; compared with nurses only working day shifts and a non-nurse control group. Methods: Sera of 44 nurses with rotating shift working (night and day) and 43 nurses working day shift only and 80 healthy subjects, who did not work shifts and were not nurses, were collected and serum PAB was measured. Results: A significant higher serum PAB value was observed in shift working and daytime nurses (152.28± 43.64 HK) in comparison to the control group (63.64 ± 34.41 HK index), P Value = 0.001. In day time nurses, also serum PAB between male (119.09 ± 47.14 HK) and female (162.53 ± 37.02 HK) in nursing workers was significant, P Value = 0.005. In the night shift working nurses, there was also a significant difference of PAB value between male (129.89 ± 35.76 HK) and female (170.46 ± 44.47 HK), P value = 0.002. Serum PAB between night shift workers (151.10± 45.02 HK) and daytime nurses (153.44± 42.66 HK) was no significant. A significant relationship was observed between serum PAB value and gender in nurses. There was no significant correlation between age and","PeriodicalId":20994,"journal":{"name":"Razavi International Journal of Medicine","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67422854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Emamifar, Soeren Hess, E. Oester-Joergensen, I. Hansen
Background: Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) is a rare, but well-defined syndrome comprising polyarthritis with symmetrical synovitis of the small joints in hands and feet accompanied by marked pitting edema. It is often considered a paraneoplastic syndrome, but here we report a case with F-18-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) findings of polymyalgia rheumatica (PMR) in a patient with RS3PE and suspected of paraneoplastic syndrome. Objectives: To briefly report the potential of FDG-PET/CT in rheumatic settings. Methods: An 83-year-old male with a history of prostate adenocarcinoma simultaneously with RS3PE presented with pain and stiffness of the shoulder and hip girdles to the department of rheumatology. He was anemic and had hypersedimentation of 106. He also complained of sore and swollen hands compatible with RS3PE. The patient had a previous course of RS3PE, presented as a paraneoplastic syndrome, together with his prostate cancer one year earlier, which resolved when the prostatic cancer was in remission. FDG-PET/CT was performed due to suspicion of repeat paraneoplastic syndrome. Results: FDG-PET/CT findings showed no evidence of malignant disease. There was diffusely increased FDG in soft tissue around the shoulders and hips and FDG-positive axillary lymph nodes consistent with PMR. Conclusions: RS3PE and PMR may belong to the same clinical entity. FDG-PET/CT has a potential role in the management of PMR as well as other rheumatic diseases.
{"title":"FDG-PET/CT Findings in a Patient with Polymyalgia Rheumatica and Accompanying Remitting Seronegative Symmetrical Synovitis with Pitting Edema","authors":"A. Emamifar, Soeren Hess, E. Oester-Joergensen, I. Hansen","doi":"10.17795/RIJM40406","DOIUrl":"https://doi.org/10.17795/RIJM40406","url":null,"abstract":"Background: Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) is a rare, but well-defined syndrome comprising polyarthritis with symmetrical synovitis of the small joints in hands and feet accompanied by marked pitting edema. It is often considered a paraneoplastic syndrome, but here we report a case with F-18-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) findings of polymyalgia rheumatica (PMR) in a patient with RS3PE and suspected of paraneoplastic syndrome. Objectives: To briefly report the potential of FDG-PET/CT in rheumatic settings. Methods: An 83-year-old male with a history of prostate adenocarcinoma simultaneously with RS3PE presented with pain and stiffness of the shoulder and hip girdles to the department of rheumatology. He was anemic and had hypersedimentation of 106. He also complained of sore and swollen hands compatible with RS3PE. The patient had a previous course of RS3PE, presented as a paraneoplastic syndrome, together with his prostate cancer one year earlier, which resolved when the prostatic cancer was in remission. FDG-PET/CT was performed due to suspicion of repeat paraneoplastic syndrome. Results: FDG-PET/CT findings showed no evidence of malignant disease. There was diffusely increased FDG in soft tissue around the shoulders and hips and FDG-positive axillary lymph nodes consistent with PMR. Conclusions: RS3PE and PMR may belong to the same clinical entity. FDG-PET/CT has a potential role in the management of PMR as well as other rheumatic diseases.","PeriodicalId":20994,"journal":{"name":"Razavi International Journal of Medicine","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67422892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Esmaeilzadeh., Hedieh Alimi, S. Hosseini, N. Samiei, Mozhgan Parsaee
Background: It has been well documented that reduced left ventricular ejection fraction (LVEF) has adverse effect on the outcome of patients with severe mitral regurgitation (MR) after mitral valve repair (MVr). However, the best method for early detection of LV dysfunction in asymptomatic or mildly symptomatic patients with MR still has not been established. Recently two dimensional speckle tracking echocardiography (2DSTE) has been used to identify subclinical alterations of myocardial deformation in many clinical settings. Objectives: Our aim was to assess the value of regional and global LV two dimensional strains to predict postoperative LV dysfunction after MVr. Methods: Twenty six patients with severe MR were evaluated. Patients were divided into two groups according to their postoperative LVEF difference, those with a post-op LVEF reduction of < 10% at 3 months (Group 1), and those with post-op LVEF reduction of ≥ 10% at 3 months (Group 2). All data were measured after 3 months follow-up and compared with pre-operative measures. Results: The occurrence of post-operative LV dysfunction was significantly related to left ventricular end-systolic dimension index (LVESDI), NYHA functional class and global longitudinal strain (GLS). A cut-off value of 19% for GLS could predict post-op LV dysfunction with a sensitivity of 89% and specificity of 77%. In addition a cut-off value of 17.7% for long axis strain with a sensitivity of 78% and specificity of 77% and a cut off value of -20% for 2-chamber strain with a sensitivity of 77% and specificity 83% could predict LV dysfunction after MVr. Conclusions: Among all measured data LV global longitudinal strain seems to be the most sensitive predictor of postoperative LV dysfunction in patients with severe MR and normal LVEF after surgical repair.
{"title":"Global and Regional Longitudinal Strains Predict Left Ventricular Dysfunction after Mitral Valve Repair: A Two Dimensional Speckle Tracking Study","authors":"M. Esmaeilzadeh., Hedieh Alimi, S. Hosseini, N. Samiei, Mozhgan Parsaee","doi":"10.5812/RIJM.41456","DOIUrl":"https://doi.org/10.5812/RIJM.41456","url":null,"abstract":"Background: It has been well documented that reduced left ventricular ejection fraction (LVEF) has adverse effect on the outcome of patients with severe mitral regurgitation (MR) after mitral valve repair (MVr). However, the best method for early detection of LV dysfunction in asymptomatic or mildly symptomatic patients with MR still has not been established. Recently two dimensional speckle tracking echocardiography (2DSTE) has been used to identify subclinical alterations of myocardial deformation in many clinical settings. Objectives: Our aim was to assess the value of regional and global LV two dimensional strains to predict postoperative LV dysfunction after MVr. Methods: Twenty six patients with severe MR were evaluated. Patients were divided into two groups according to their postoperative LVEF difference, those with a post-op LVEF reduction of < 10% at 3 months (Group 1), and those with post-op LVEF reduction of ≥ 10% at 3 months (Group 2). All data were measured after 3 months follow-up and compared with pre-operative measures. Results: The occurrence of post-operative LV dysfunction was significantly related to left ventricular end-systolic dimension index (LVESDI), NYHA functional class and global longitudinal strain (GLS). A cut-off value of 19% for GLS could predict post-op LV dysfunction with a sensitivity of 89% and specificity of 77%. In addition a cut-off value of 17.7% for long axis strain with a sensitivity of 78% and specificity of 77% and a cut off value of -20% for 2-chamber strain with a sensitivity of 77% and specificity 83% could predict LV dysfunction after MVr. Conclusions: Among all measured data LV global longitudinal strain seems to be the most sensitive predictor of postoperative LV dysfunction in patients with severe MR and normal LVEF after surgical repair.","PeriodicalId":20994,"journal":{"name":"Razavi International Journal of Medicine","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71297085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Roushani, S. B. Nejad, N. Arshadi, M. M. Honarmand, A. Fakhri
Background: Social anxiety is an extremely harmful disorder affecting many aspects of life and causes limited capability of encountering social situations among individuals. Objectives: The purpose of this study was to examine the efficacy of the unified transdiagnostic treatment on social anxiety and positive and negative affect in students. Methods: The statistical population of this study included all female undergraduate students with social anxiety in Ahvaz Jundishapur University of Medical Sciences. 32 female undergraduate students of medical sciences university of Ahvaz were selected among those with social anxiety score of 19 or more (cut-off score) through multistage random samplingmethodand were randomly placed in experimental and control groups. Social phobia inventory (SPIN) and positive and negative affect schedule (PANAS) were implemented on subjects of both groups before and after conducting the intervention. Unified transdiagnostic treatment was performed on the experimental group within 8 sessions of 90 minutes, but the control group received no intervention. Data were analyzed by multivariate covariance analysis. Results: Results showed a significant difference between experimental and control groups in terms of social anxiety and negative and positive affect, and unified transdiagnostic treatmenthas reduced social anxiety and negative affect and also has increased positive affect in experimental group. Conclusions: It may be concluded based on the results of this study that unified transdiagnostic treatment is effective on recovery of social anxiety and negative and positive affects among the students. Therefore, clinical therapists are advised to use this interven-
{"title":"Examining the Efficacy of the Unified Transdiagnostic Treatment on Social Anxiety and Positive and Negative Affect in Students","authors":"K. Roushani, S. B. Nejad, N. Arshadi, M. M. Honarmand, A. Fakhri","doi":"10.17795/RIJM41233","DOIUrl":"https://doi.org/10.17795/RIJM41233","url":null,"abstract":"Background: Social anxiety is an extremely harmful disorder affecting many aspects of life and causes limited capability of encountering social situations among individuals. Objectives: The purpose of this study was to examine the efficacy of the unified transdiagnostic treatment on social anxiety and positive and negative affect in students. Methods: The statistical population of this study included all female undergraduate students with social anxiety in Ahvaz Jundishapur University of Medical Sciences. 32 female undergraduate students of medical sciences university of Ahvaz were selected among those with social anxiety score of 19 or more (cut-off score) through multistage random samplingmethodand were randomly placed in experimental and control groups. Social phobia inventory (SPIN) and positive and negative affect schedule (PANAS) were implemented on subjects of both groups before and after conducting the intervention. Unified transdiagnostic treatment was performed on the experimental group within 8 sessions of 90 minutes, but the control group received no intervention. Data were analyzed by multivariate covariance analysis. Results: Results showed a significant difference between experimental and control groups in terms of social anxiety and negative and positive affect, and unified transdiagnostic treatmenthas reduced social anxiety and negative affect and also has increased positive affect in experimental group. Conclusions: It may be concluded based on the results of this study that unified transdiagnostic treatment is effective on recovery of social anxiety and negative and positive affects among the students. Therefore, clinical therapists are advised to use this interven-","PeriodicalId":20994,"journal":{"name":"Razavi International Journal of Medicine","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67422905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Akbari, H. Ameri, Hasan Jamali, A. Gholami, S. Majidinia
Background: Endodontically treated teeth need to be restored in a manner to provide protection for the remaining tooth structure but would also allow the restoration of esthetic and functional demands. Objectives: This study evaluates the clinical success rate of endodontically treated premolars restored with different techniques. Methods: In this study, 96 participants were included with indication of endodontic treatment of one maxillary or mandibular premolar. Only cases with premolars along with MOD Class II carious lesions and preserved cusp structure were recruited. After endodontic treatment subjects were randomly assigned to one of the following restoration methods: (1) composite restoration without any cusp reduction (2) Composite associated with a fiber reinforced composite (FRC) post (3) capping the buccal and lingual cusp and composite restoration. Subjects were recalled for the clinical and radiographical evaluations with modified USPHS criteria after three, six and 12 months. Results: During the evaluation period, all the three methods of restoration, achieved the Alpha degree in term of modified USPHS criteria. Conclusions: The clinical success rates of endodontically treated premolars restored with fiber posts and direct composite restorations, direct composite restorations with cusp capping and simple direct composite restoration were perfect after one year of follow-
{"title":"One-Year Clinical Comparison of Survival of Endodontically Treated Premolar Restored with Different Direct Restoration Technique: A Prospective Cohort Study","authors":"M. Akbari, H. Ameri, Hasan Jamali, A. Gholami, S. Majidinia","doi":"10.17795/RIJM39800","DOIUrl":"https://doi.org/10.17795/RIJM39800","url":null,"abstract":"Background: Endodontically treated teeth need to be restored in a manner to provide protection for the remaining tooth structure but would also allow the restoration of esthetic and functional demands. Objectives: This study evaluates the clinical success rate of endodontically treated premolars restored with different techniques. Methods: In this study, 96 participants were included with indication of endodontic treatment of one maxillary or mandibular premolar. Only cases with premolars along with MOD Class II carious lesions and preserved cusp structure were recruited. After endodontic treatment subjects were randomly assigned to one of the following restoration methods: (1) composite restoration without any cusp reduction (2) Composite associated with a fiber reinforced composite (FRC) post (3) capping the buccal and lingual cusp and composite restoration. Subjects were recalled for the clinical and radiographical evaluations with modified USPHS criteria after three, six and 12 months. Results: During the evaluation period, all the three methods of restoration, achieved the Alpha degree in term of modified USPHS criteria. Conclusions: The clinical success rates of endodontically treated premolars restored with fiber posts and direct composite restorations, direct composite restorations with cusp capping and simple direct composite restoration were perfect after one year of follow-","PeriodicalId":20994,"journal":{"name":"Razavi International Journal of Medicine","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67422754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Spitz Nevus is an infrequent acquired melanocytic nevus. There is still a challenge for dermatopathologists in distinguishing spitz nevus from malignant melanoma particularly in adults since there is no immunohistochemistry or molecular markers which differentiate Spitz Nevus from melanoma. Objectives: The aim of this study is to make clear what clinico-histopathological features of Spitz Nevus are in order to reduce malpractice due to misdiagnosis. Methods: In the present study, a series of twenty two patients have been reviewed who were diagnosed with Spitz Nevous based on proved histopathology features between the years 2009 2013. The patients were evaluated for demographic parameters like age, sex, clinical differential diagnosis, cutaneous location of tumor, tumor diameter, subtype, symmetry, maturation, upper clefting of melanocytic nest, shoulder phenomena, epidermal hyperplasia, type, kamino body, mitotic rate , inflammatory infiltration, pagetoid spread and regression. Results: In our study, 45% of patients were younger than 10 years old. The average age of patients was 14± 11.37. Male to female ratio was 1.44. The commonest location was head and neck. Spitz nevus was the first clinical differential diagnosis in 20% of patients. The commonest variant type was conventional type and then polypoid and desmoplastic types. The mean size of nevi was 0.81 ± 0.59 mm. About 59% of nevi shows epithelioid cytologic features. Other histologic parameters from the most to the least frequency were symmetry (100%), maturation (100%), epidermal hyperplasia (77.3%), kamino body (68.2%), subtype (compound 68%), mitotic rate (63.6%), clefting (59%), inflammatory infiltration (54.5%), pagetoid spread (18.2%), shoulder (37.5%) and regression (9.1%). Conclusions: We tried to hifhlight some clinical and histopathological features which are distinguishing Spitz nevus from other melanocytic nevi even malignant melanoma.
{"title":"Clinical and Histopathology Features of Spitz Nevus: In 22 Cases","authors":"M. Rahbar, A. Ghannadan, K. Kamyab","doi":"10.17795/RIJM26787","DOIUrl":"https://doi.org/10.17795/RIJM26787","url":null,"abstract":"Background: Spitz Nevus is an infrequent acquired melanocytic nevus. There is still a challenge for dermatopathologists in distinguishing spitz nevus from malignant melanoma particularly in adults since there is no immunohistochemistry or molecular markers which differentiate Spitz Nevus from melanoma. Objectives: The aim of this study is to make clear what clinico-histopathological features of Spitz Nevus are in order to reduce malpractice due to misdiagnosis. Methods: In the present study, a series of twenty two patients have been reviewed who were diagnosed with Spitz Nevous based on proved histopathology features between the years 2009 2013. The patients were evaluated for demographic parameters like age, sex, clinical differential diagnosis, cutaneous location of tumor, tumor diameter, subtype, symmetry, maturation, upper clefting of melanocytic nest, shoulder phenomena, epidermal hyperplasia, type, kamino body, mitotic rate , inflammatory infiltration, pagetoid spread and regression. Results: In our study, 45% of patients were younger than 10 years old. The average age of patients was 14± 11.37. Male to female ratio was 1.44. The commonest location was head and neck. Spitz nevus was the first clinical differential diagnosis in 20% of patients. The commonest variant type was conventional type and then polypoid and desmoplastic types. The mean size of nevi was 0.81 ± 0.59 mm. About 59% of nevi shows epithelioid cytologic features. Other histologic parameters from the most to the least frequency were symmetry (100%), maturation (100%), epidermal hyperplasia (77.3%), kamino body (68.2%), subtype (compound 68%), mitotic rate (63.6%), clefting (59%), inflammatory infiltration (54.5%), pagetoid spread (18.2%), shoulder (37.5%) and regression (9.1%). Conclusions: We tried to hifhlight some clinical and histopathological features which are distinguishing Spitz nevus from other melanocytic nevi even malignant melanoma.","PeriodicalId":20994,"journal":{"name":"Razavi International Journal of Medicine","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67419698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Self-esteem is a stable sense of personal worthiness. There is insufficient evidence from the available research to fully determine the relationship between self-esteem and early trauma. Objectives: This is a correlational study aims to investigate the relationship between early traumas as a predictor of negative selfesteem by controlling the effect of maladaptive schemas in 11-13 year-old-student sample. Methods: 292 people (201 females, 91 males) with mean age of 12.33 were selected via multistage random sampling. Participants completed questionnaire on children’s depression inventory (CDI), childhood trauma questionnaire (CTQ), schema inventory for children (SIC) and provided demographic information. Analyzing data was done using correlation and stepwise regression meth-
{"title":"The Predictive Role of Early Trauma Dimensions on Self-Esteem in 11 - 13- Year-Old Students: Controlling the Role of Maladaptive Schema","authors":"S. F. Sajjadi, Y. Zargar, L. Zare, F. Tajikzadeh","doi":"10.17795/RIJM38869","DOIUrl":"https://doi.org/10.17795/RIJM38869","url":null,"abstract":"Background: Self-esteem is a stable sense of personal worthiness. There is insufficient evidence from the available research to fully determine the relationship between self-esteem and early trauma. Objectives: This is a correlational study aims to investigate the relationship between early traumas as a predictor of negative selfesteem by controlling the effect of maladaptive schemas in 11-13 year-old-student sample. Methods: 292 people (201 females, 91 males) with mean age of 12.33 were selected via multistage random sampling. Participants completed questionnaire on children’s depression inventory (CDI), childhood trauma questionnaire (CTQ), schema inventory for children (SIC) and provided demographic information. Analyzing data was done using correlation and stepwise regression meth-","PeriodicalId":20994,"journal":{"name":"Razavi International Journal of Medicine","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67422702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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