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Radiation safety for pregnant women with COVID-19: a review article COVID-19孕妇的辐射安全:一篇综述文章
IF 1.1 4区 医学 Q2 Energy Pub Date : 2022-04-01 DOI: 10.1051/radiopro/2022012
N. Ataalla
In the midst of the catastrophic outbreak of coronavirus COVID-19, potentially life-saving treatments for pregnant women cannot be ignored. Pulmonary infection or pneumonia is a common complication of COVID-19. Radiologic imaging plays a critical role in both controlling the disease and evaluating the consequences of coronavirus COVID-19 pneumonia. Lung ultrasound (LUS) and chest-computed tomography (CT) are the most commonly used procedures to detect and treat COVID-19 and can predict and prognosticate the impact on patients of COVID-19. In this context a deep understanding of the effects of ionizing radiation and its hazards is required and radiological examinations should be used cautiously in pregnant women. The aim of this review is to discuss radiation protection issues for pregnant women with COVID-19 during radiological examination with regard to the effects on the fetuses. An evaluation of electronic databases for publications in English was performed for coronavirus, symptoms, detection, and radiation risk in pregnancy. In such circumstances, international rules or standard protocols need to be established to assist physicians and radiologists in the necessary measures for detection, control and follow-up of COVID-19 during pregnancy. The review found that lung examinations with LUS are an effective alternative to CT.
在冠状病毒COVID-19灾难性爆发期间,对孕妇可能挽救生命的治疗方法不容忽视。肺部感染或肺炎是COVID-19的常见并发症。放射成像在控制疾病和评估冠状病毒COVID-19肺炎后果方面发挥着关键作用。肺部超声(LUS)和胸部计算机断层扫描(CT)是检测和治疗COVID-19最常用的程序,可以预测和预测COVID-19对患者的影响。在这方面,需要深入了解电离辐射的影响及其危害,对孕妇应谨慎使用放射检查。本文旨在探讨COVID-19孕妇在放射检查时的辐射防护问题以及对胎儿的影响。对英文出版物的电子数据库进行了冠状病毒、症状、检测和孕期辐射风险的评估。在这种情况下,需要制定国际规则或标准方案,以协助医生和放射科医生采取必要措施,在怀孕期间检测、控制和随访COVID-19。回顾发现LUS肺部检查是CT的有效替代方法。
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引用次数: 0
Evaluation of influencing factors on the radiation dose of hospitalized neonates: Maturity status and type of disease 住院新生儿辐射剂量影响因素评价:成熟度、疾病类型
IF 1.1 4区 医学 Q2 Energy Pub Date : 2022-04-01 DOI: 10.1051/radiopro/2022013
F. Yarmahmoodi, S. Qasemian, R. Ravanfar Haghighi, S. M. Razavinejad, B. Zeinali-Rafsanjani
Context: Premature neonates have multiple medical and surgical problems; therefore, hospitalization and imaging are required. Recently there has been too much concern about the long-term effects of radiation in neonates. In this survey, we assessed the frequency of imaging and radiation dose in neonates hospitalized in neonatal intensive care unit (NICU) in our University-affiliated hospital. Materials and methods: This was a retrospective cross-sectional study conducted during a year (2019–2020) on 291 neonates. The information has been gathered from Health Information System and picture archiving and communication system, and analyzed with SPSS version 22. Results: 291 neonates were included in the study, from which 175 (60%) neonates were preterm and 116 (40%) neonates were term neonates. The mean gestational age (GA) was 35.5 weeks and the mean hospital admission duration was 15.8 days. The mean number of portable and non-portable imaging procedures was 5.13 and 0.62 for preterm and term neonates, respectively. There is a statistically significant relationship between gastrointestinal disease and the number of abdominal X-rays. There is also a statistically significant relationship between acute respiratory distress syndrome (ARDS) and chest X-rays; there is no statistically significant relationship between pneumonia and the number of chest X-rays in the hospital course. The mean accumulation effective doses in preterm and term neonates in-hospital course were 0.549 and 0.498 mSv, respectively. Discussion: The neonates in NICU are more susceptible to radiation hazards due to numerous imaging than other neonates. Portable imaging is eight times more dosing than non-portable imaging, so due to the scattered radiation from portable devices, the actual radiation dose may be higher than what we estimated. No brain CT scan was done for the neonates with convulsion because of using safer and more valuable modalities; so we could recommend radiologists and pediatrics to use substitute modalities like sonography and MRI instead of CT scan and X-rays.
背景:早产儿有多种内科和外科问题;因此,需要住院和影像学检查。最近有太多关于辐射对新生儿的长期影响的担忧。在这项调查中,我们评估了在大学附属医院新生儿重症监护病房(NICU)住院的新生儿的成像频率和辐射剂量。材料与方法:本研究是一项为期一年(2019-2020年)的回顾性横断面研究,研究对象为291名新生儿。从卫生信息系统和图片存档和通讯系统中收集信息,并使用SPSS 22进行分析。结果:291例新生儿纳入研究,其中早产儿175例(60%),足月新生儿116例(40%)。平均胎龄35.5周,平均住院时间15.8天。对于早产儿和足月新生儿,便携式和非便携式成像程序的平均次数分别为5.13次和0.62次。胃肠疾病与腹部x光检查次数有统计学意义的关系。急性呼吸窘迫综合征(ARDS)与胸部x光片之间也有统计学意义的关系;肺炎与住院期间胸片次数之间无统计学意义的关系。早产儿和足月新生儿住院期间的平均累积有效剂量分别为0.549和0.498 mSv。讨论:新生儿重症监护病房(NICU)新生儿因影像学检查较多,较其他新生儿更易受到辐射危害。便携式成像的剂量是非便携式成像的8倍,因此由于便携式设备的散射辐射,实际辐射剂量可能高于我们的估计。由于采用更安全、更有价值的方式,未对惊厥新生儿进行脑CT扫描;所以我们可以建议放射科医生和儿科医生使用替代方式,比如超声和核磁共振成像,而不是CT扫描和x射线。
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引用次数: 0
Maintenir les recommandations de la CIPR adaptées aux besoins 保持icrp的建议符合需要
IF 1.1 4区 医学 Q2 Energy Pub Date : 2022-04-01 DOI: 10.1051/radiopro/2022010
C. Clement, W. Rühm, J. Harrison, K. Applegate, D. Cool, Conny Larsson, C. Cousins, J. Lochard, S. Bouffler, K. Cho, M. Kai, D. Laurier, S. Liu, S. Romanov
La Commission internationale de protection radiologique (CIPR) a initié un examen et une révision du système de radioprotection afin de mettre à jour les recommandations générales de 2007 dans la Publication 103 de la CIPR. Il s’agit du début d’un processus de plusieurs années qui nécessite une collaboration ouverte et transparente avec les organismes et les personnes du monde entier. Bien que le système soit robuste et efficace, il convient de l’adapter à l’évolution des connaissances scientifiques et de la société afin de demeurer adapté aux besoins. Le présent document vise à encourager les discussions sur les domaines du système qui pourraient bénéficier le plus d’un examen, et à engager des initiatives de collaboration. Le renforcement de la clarté et de la cohérence constitue une priorité. Plus le degré de compréhension du système est élevé, plus il est possible de l’appliquer efficacement, ce qui se traduit par une amélioration de la protection et une harmonisation accrue. De nombreux domaines pourraient faire l’objet d’un examen, notamment : la classification des effets, avec un accent particulier sur les réactions tissulaires ; la reformulation du détriment radiologique, qui pourrait inclure les maladies non cancéreuses ; la réévaluation de la relation entre le détriment et la dose efficace, et la possibilité de définir des détriments pour les hommes et les femmes et différentes classes d’âge ; la variation de la réponse individuelle à l’exposition aux rayonnements ; les effets héréditaires ; les effets et risques pour le biote non humain et les écosystèmes. Certains des concepts de base sont également examinés, notamment le cadre permettant de réunir la protection des personnes et de l’environnement, les améliorations progressives des principes fondamentaux de justification et d’optimisation, une approche plus large de la protection des personnes et la clarification des situations d’exposition introduites en 2007. En outre, la CIPR envisage de déterminer dans quels cas l’incorporation explicite des fondements éthiques dans le système présenterait un avantage, comment mieux refléter l’importance des échanges et de l’implication des parties prenantes, et de donner des conseils supplémentaires sur l’éducation et la formation. La CIPR invite à répondre à ces questions et à d’autres liées à l’examen du système de radioprotection.
国际辐射防护委员会(icrp)对辐射防护系统进行了审查和修订,以更新icrp第103号出版物2007年的一般建议。这是一个多年进程的开始,需要与世界各地的组织和个人进行公开和透明的合作。虽然该系统是强大和有效的,但它必须适应科学知识和社会的发展,以保持对需求的响应。本文件的目的是鼓励就系统中可能从审查中受益最大的领域进行讨论,并发起合作倡议。提高清晰度和一致性是一个优先事项。对这一制度的了解程度越高,就越有可能有效地应用这一制度,从而加强保护和协调。许多领域可以考虑,包括:影响分类,特别强调组织反应;重新制定辐射危害,其中可能包括非癌症疾病;重新评估危害和有效剂量之间的关系,以及为男性和女性以及不同年龄组定义营养成分的可能性;个体对辐射照射反应的变化;遗传效应;对非人类生物群和生态系统的影响和风险。讨论的一些基本概念,也包括平台搜集、保护人员和环境的逐步改善的理由和优化的基本原则,采取更广泛的保护人员和2007年提出的澄清暴露情况。此外,icrp正在考虑确定在何种情况下将明确的道德基础纳入系统将是有益的,如何更好地反映利益攸关方交流和参与的重要性,并在教育和培训方面提供额外的指导。icrp要求回答这些问题和其他与辐射防护系统审查有关的问题。
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引用次数: 9
Patient radiation dose and lifetime attributable risk of cancer due to ionizing radiation in cardiovascular interventional radiological procedures 心血管介入放射治疗中电离辐射引起的患者辐射剂量和终身归因癌症风险
IF 1.1 4区 医学 Q2 Energy Pub Date : 2022-04-01 DOI: 10.1051/radiopro/2022011
M. Jamshidi, A. Keshavarz, A. Karami, Y. Salimi, G. Valizadeh
The aim of this study is to calculate the patient radiation dose and Lifetime Attributable Risk (LAR) in Cardiovascular Interventional Radiological (CVIR) procedures. The patient population included 327 patients who underwent Coronary Angiography (CA) and Percutaneous Coronary Interventions (PCI). Exposure data were reported for every examination such as Kerma-Area Product (KAP), fluoroscopy time and number of exposures. Organ dose and effective dose were assessed by PCXMC software. LAR values were determined according to BEIR VII report. The mean effective dose per examination in CA is 12.6 mSv for males and 10.25 mSv for females. In PCI, the mean effective dose is 18.06 mSv for males and 22.73 mSv for females. Organs with highest dose are thymus, heart, breast, and lung. The mean of LAR value in CA is 62 and 60 for males and females, respectively. In PCI, the mean of LAR value is 89 and 132 for males and females, respectively. Also, the KAP to effective dose conversion factors (CFKAP-ED) were calculated. CFKAP-ED for CA is 0.249 in males and 0.228 in females, and for PCI is 0.2446 and 0.2316 for males and females, respectively. This study will help better understand the concept of ionizing radiation dose in the CVIR procedures and how the individual patient’s effective dose and LAR can evaluate the cancer risk.
本研究的目的是计算心血管介入放射(CVIR)手术中患者的辐射剂量和终生归因风险(LAR)。患者群体包括327例接受冠状动脉造影(CA)和经皮冠状动脉介入治疗(PCI)的患者。报告每次检查的暴露数据,如Kerma-Area Product (KAP)、透视时间和暴露次数。采用PCXMC软件测定器官剂量和有效剂量。根据BEIR VII报告确定LAR值。CA每次检查的平均有效剂量为男性12.6毫西弗,女性10.25毫西弗。在PCI中,男性的平均有效剂量为18.06毫西弗,女性为22.73毫西弗。剂量最高的器官是胸腺、心脏、乳房和肺。男性和女性CA的平均LAR值分别为62和60。在PCI中,男性和女性的平均LAR值分别为89和132。并计算KAP与有效剂量转换因子(CFKAP-ED)。CA的CFKAP-ED男性为0.249,女性为0.228,PCI的CFKAP-ED男性为0.2446,女性为0.2316。本研究将有助于更好地理解CVIR程序中电离辐射剂量的概念,以及个体患者的有效剂量和LAR如何评估癌症风险。
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引用次数: 3
Vers de nouvelles recommandations en radioprotection : la CIPR en marche / Towards new recommendations in radiological protection: ICRP on the move 放射防护的新建议:la CIPR en marche /迈向放射防护的新建议:ICRP正在行动
IF 1.1 4区 医学 Q2 Energy Pub Date : 2022-04-01 DOI: 10.1051/radiopro/2022014
Michel Bourguignon
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引用次数: 6
Assessment of pediatric radiation doses in brain CT procedures 脑CT程序中儿童辐射剂量的评估
IF 1.1 4区 医学 Q2 Energy Pub Date : 2022-01-01 DOI: 10.1051/radiopro/2022027
O. Bawazeer, Rizwan Muhammad, M. Alhazmi, N. Asiri, T. Mohammed, A. Alsaab, M. Algethami, A. Sedayo, A. Ajlouni
Background:To date in Saudi Arabia, a limited number of studies conducted to assess radiation doses received by pediatrics in computed tomography (CT) brain procedure. National diagnostic reference levels (NDRL) have been established for adults, but neither NDRL’s nor Local diagnostic reference levels (LDRL) have been established for pediatric patients. Objective: This study aimed to assess radiation doses experienced by pediatric patients in CT brain procedure, and derive LDRLs. Materials and methods: The values of three radiological indexes: volume CT dose index (CTDIvol) and dose-length product (DLP) were assessed. Then effective dose (ED) were estimated, and LDRLs are suggested for CT procedures based on data retrieved from 353 pediatric patients aged between 0 and 15 years old. LDRLs were estimated based on age and weight. Results: Built on 75 percent of the median distribution of the CTDIvol and DLP values, weight assemblage LDRL values ranged from 12.29 to 28.72 mGy and from 173.32 to 565.38 mGy.cm, respectively, whereas age assemblage LDRL values ranged from 11.76 to 25.07 mGy and from 147.04 to 479.23 mGy.cm, respectively. Conclusion: This study derived the typical CTDIvol, DLP, and ED received by pediatric patient during CT brain procedure in Saudi Arabia. Then, LDRLs were proposed based on age and weight for pediatric patients aged between 0 to 15 years old.
背景:迄今为止,在沙特阿拉伯,进行了数量有限的研究,以评估儿科在计算机断层扫描(CT)脑部手术中接受的辐射剂量。国家诊断参考水平(NDRL)已为成人建立,但NDRL和地方诊断参考水平(LDRL)均未为儿科患者建立。目的:本研究旨在评估儿科患者在CT脑部手术中所经历的辐射剂量,并得出LDRLs。材料与方法:评估体积CT剂量指数(CTDIvol)和剂量-长度积(DLP)三个放射学指标的值。然后估计有效剂量(ED),并根据353例年龄在0 - 15岁之间的儿童患者的数据,建议CT手术的ldrl。ldrl是根据年龄和体重来估计的。结果:基于75%的CTDIvol和DLP值的中位数分布,权重组合LDRL值范围为12.29 ~ 28.72 mGy和173.32 ~ 565.38 mGy。年龄组合LDRL值分别为11.76 ~ 25.07 mGy和147.04 ~ 479.23 mGy。厘米,分别。结论:本研究得出了沙特阿拉伯儿童患者在CT脑部手术期间接受的典型CTDIvol、DLP和ED。然后,针对0 ~ 15岁的儿童患者,提出了基于年龄和体重的ldrl。
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引用次数: 3
Establishing local diagnostic reference levels for adult computed tomography in Morocco 在摩洛哥建立成人计算机断层扫描的当地诊断参考水平
IF 1.1 4区 医学 Q2 Energy Pub Date : 2022-01-01 DOI: 10.1051/radiopro/2021035
M. El Mansouri, M. Talbi, A. Choukri, O. Nhila, M. Aabid
In Morocco, the radiation doses received by adult patients are increasing due to the number of CT examinations performed and the larger number of computed tomography (CT) scanners installed. The aim of this study was to evaluate the radiation doses received by patients for the most common adult CT examinations in order to establish local diagnostic reference levels (DRLs). Data from 1016 adult patients were collected during 3 months from four Moroccan hospitals. Dose length product (DLP) and volumetric computed tomography dose index (CTDIvol) were evaluated by determining the 75th percentile as diagnostic reference levels for the most common examinations including head, chest and abdomen. The DRL for each examination was compared with other studies. The established DRLs in Morocco in terms of CTDIvol were 57.4, 12.3 and 10.9 for CT examinations of the head, chest, abdomen, respectively. For DLP, they were 1020, 632 and 714, respectively. These established DRLs for CTDIvol were almost similar to the UK DRLs at all examinations, higher than the Egyptian DRLs and lower than the Japanese DRLs at the head CT examination, lower than the DRLs from Egypt and Japan at the CT abdomen examination. In terms of DLP, the DRLs were higher than those of the British studies, lower than those of the Egyptian and Japanese studies at the head CT examination were higher at chest CT and lower at abdominal CT than those of all selected studies. The higher level of established DRLs in our study demonstrates the requirement of an optimization process while keeping a good image quality for a reliable diagnosis.
在摩洛哥,由于进行了CT检查的次数和安装了更多的计算机断层扫描(CT)扫描仪,成年病人接受的辐射剂量正在增加。本研究的目的是评估最常见的成人CT检查患者所接受的辐射剂量,以建立局部诊断参考水平(DRLs)。在三个月内从摩洛哥四家医院收集了1016名成年患者的数据。剂量长度积(DLP)和体积计算机断层扫描剂量指数(CTDIvol)通过确定第75百分位数作为诊断参考水平对最常见的检查进行评估,包括头部,胸部和腹部。将每次检查的DRL与其他研究进行比较。在摩洛哥,CT检查头部、胸部、腹部的CTDIvol分别为57.4、12.3和10.9。民主劳动党为1020人,632人,714人。这些已建立的CTDIvol的drl在所有检查中几乎与英国的drl相似,在头部CT检查中高于埃及的drl,低于日本的drl,在腹部CT检查中低于埃及和日本的drl。在DLP方面,drl高于英国研究,低于埃及和日本研究,头部CT检查高于胸部CT,腹部CT低于所有入选研究。在我们的研究中,更高水平的已建立的drl表明了优化过程的要求,同时保持良好的图像质量以进行可靠的诊断。
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引用次数: 4
Effects of high ambient temperature on the accuracy of thermoluminescent dosimeters for environmental monitoring 高环境温度对环境监测用热释光剂量计精度的影响
IF 1.1 4区 医学 Q2 Energy Pub Date : 2022-01-01 DOI: 10.1051/radiopro/2022018
S. Al-Shehri, N. Shubayr, A. Alghamdi, A. Alshahrani, Y. Mubarki, A. Al-Shehri, Y. Alashban
Thermoluminescence dosimeters (TLDs) are widely used for both personal and environmental dosimetry. TLDs should have high accuracy under different conditions. The TL signal can drop over time because of fading (loss of signal due to thermally induced recombination of trapped charriers), thus leading to underestimation of the irradiation dose. The Saudi climate is extremely hot for most of the year, which could significantly affect TLD measurements. Therefore, the effect of ambient temperature, storage time and irradiation dose were investigated both in laboratory controlled-temperature conditions and field experiments, for two commercial dosimeters: Harshaw (TLD-100H™) and RADCARD (MCP-N™), which are used for environmental monitoring. The irradiated TLDs were exposed to a range of ambient temperatures (25 °C–65 °C) then stored for 30, 60, and 90 days. A signal fading due to increasing ambient temperature and storage time was generally observed. MCP-N shows good stability and is less responsive to increasing ambient temperature compared to TLD-100H. TLD-100H is less affected by storage time compared to MCP-N. Irradiation doses play a role in TL signal fading, and TLDs irradiated with 5 mSv have a higher rate of loss compared to those irradiated with 2 mSv in all TLD types. The obtained results permitted to conclude that all TLD types used in this study suffer from TL signal fading, and its degree varies between TLD types.
热释光剂量计(tld)广泛用于个人和环境剂量测定。tld在不同条件下应具有较高的精度。由于衰落(由于热诱导捕获的载流子重组而导致的信号损失),TL信号会随着时间的推移而下降,从而导致辐照剂量的低估。沙特的气候在一年中的大部分时间里都非常炎热,这可能会严重影响TLD的测量。因此,在实验室控制温度条件下和现场实验中,研究了环境温度、储存时间和辐照剂量的影响,使用了两种用于环境监测的商用剂量计:Harshaw (TLD-100H™)和RADCARD (MCP-N™)。辐照后的tld暴露于环境温度范围(25°C - 65°C),然后保存30、60和90天。由于环境温度和储存时间的增加,通常会观察到信号衰落。与TLD-100H相比,MCP-N表现出良好的稳定性,对环境温度升高的响应较小。与MCP-N相比,TLD-100H受储存时间的影响较小。辐射剂量在TL信号衰减中起作用,在所有类型的TLD中,5毫西弗辐射的TLD的损失率高于2毫西弗辐射的TLD。所得结果可以得出结论,本研究中使用的所有TLD类型都存在TL信号衰落,其程度因TLD类型而异。
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引用次数: 0
Career burnout and psychological consistency among radiation workers in China: a cross section study 中国辐射工作人员职业倦怠与心理一致性的横断面研究
IF 1.1 4区 医学 Q2 Energy Pub Date : 2022-01-01 DOI: 10.1051/radiopro/2022019
L. Cui, Z. Feng, H. Xu
We conducted a survey on the mental status, including burnout, sense of coherence (SOC) and anxiety about radiation exposure among medical radiation workers in China. SOC levels were evaluated through a validated scale, SOC-13. Burnout was measured using the 22-item version of Maslach Burnout Inventory Human Services Survey for Medical Personnel (MBI-HSS). A total of 277 medical radiation workers answered the questionnaire. The mean values of SOC-13 and burnout were 50 (SD 13.5) and 79.7 (SD 25.7), respectively. The sum scores of SOC-13 and MBI-HSS were significantly linear correlated (p < 0.01, F = 284.239, adjusted R2 = 0.506). Anxiety about radiation exposure was significantly associated with intention to leave employment (χ2 = 66.535, p < 0.001, Cramer’s v = 0.347, p < 0.001). The participants who have no anxiety about radiation exposure have significantly higher scores of sense of coherence than those who have mild and moderate anxiety (p < 0.01); they have lower scores of burnout (p < 0.01). The participants who have no intention to leave employment have significantly higher scores of sense of coherence and lower scores of burnout than those who have an intention or hesitate to leave (p < 0.01). Most participants in this study showed considerable caution about whether to participate in radiation work during pregnancy. Anxiety about radiation exposure was considered a contributing factor for burnout and led to the intention to leave employment. Efforts to design targeted interventions, such as educational programs, to mitigate radiation anxiety in medical radiation workers are warranted.
本研究对中国医疗放射工作者的辐射暴露心理状态进行了调查,包括职业倦怠、一致性感(SOC)和焦虑。通过一个有效的量表SOC-13来评估SOC水平。工作倦怠采用22项版本的Maslach医务人员职业倦怠量表(MBI-HSS)进行测量。共有277名放射医疗工作者回答了问卷。SOC-13和倦怠的平均值分别为50 (SD 13.5)和79.7 (SD 25.7)。SOC-13总分与MBI-HSS总分呈显著线性相关(p < 0.01, F = 284.239,调整后R2 = 0.506)。辐射暴露焦虑与离职意向显著相关(χ2 = 66.535, p < 0.001, Cramer’s v = 0.347, p < 0.001)。无辐射暴露焦虑者的连贯感得分显著高于轻度和中度焦虑者(p < 0.01);职业倦怠得分较低(p < 0.01)。无离职意向者的连贯感得分显著高于有离职意向者或有离职犹豫者,倦怠感得分显著低于有离职意向者(p < 0.01)。这项研究的大多数参与者对是否在怀孕期间参与辐射工作表现出相当谨慎的态度。对辐射暴露的焦虑被认为是倦怠的一个促成因素,并导致离职的意图。努力设计有针对性的干预措施,如教育计划,以减轻医疗辐射工作者的辐射焦虑是有必要的。
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引用次数: 1
Évaluation des risques en radioprotection : aller au-delà de la réponse du modèle linéaire sans seuil / Risk evaluation in radiological protection: going beyond the linear no-threshold model response 辐射防护风险评估:超越线性无阈值模型响应/辐射防护风险评估:超越线性无阈值模型响应
IF 1.1 4区 医学 Q2 Energy Pub Date : 2022-01-01 DOI: 10.1051/radiopro/2022025
Michel Bourguignon
Dans ce numéro de Radioprotection, Jean-Marc Cosset utilise le modèle linéaire sans seuil (LNT) pour s’interroger sur l’évaluation des risques liés à la radiothérapie (Cosset, 2022). L’évaluation du risque engendré par une exposition aux rayonnements ionisants (RI) reste un enjeu puisque l’ensemble de la population est continuellement exposé : les principales expositions sont les expositions médicales, la radioactivité naturelle, les rayonnements cosmiques à bord des avions long courrier et, exceptionnellement, les expositions après un accident nucléaire. Jusqu’à présent, pour évaluer le risque d’apparition d’effets stochastiques, principalement le cancer, la plupart des organisations internationales ont privilégié le modèle de risque linéaire sans seuil (LNT) recommandé par la Commission internationale de protection radiologique (CIPR). Ce modèle est basé sur l’utilisation de la dose efficace, grandeur dosimétrique ajustée au risque et calculée à partir de données épidémiologiques du suivi à long terme des survivants des bombes atomiques d’Hiroshima-Nagasaki exposés à une très forte dose à fort débit de dose (ICRP, 2007). Les études ultérieures avec les travailleurs du nucléaire et les patients avec des profils d’exposition très différents (débits de dose variés et répétitions de doses) n’ont pas remis en cause le modèle, même si elles font apparaître des non-linéarités aux faibles doses (ICRP, 2021). Cependant, le risque attribuable sur la durée de vie, prenant aussi en compte les données des personnes non exposées, est plus précis que la dose efficace pour évaluer le risque d’une exposition aux rayonnements ionisants (RI), en particulier chez les femmes (ICRP, 2007 ; Jamshidi et al., 2022). Le modèle LNT implique qu’il n’existe pas de seuil d’induction du risque de cancer après irradiation, autrement dit, même de très faibles doses de RI présentent un risque. Récemment, la CIPR a défini les faibles doses comme< 100mGy de rayonnement à faible transfert linéique d’énergie pour les organes et les tissus, et les faibles débits de dose comme < 5mGy/h (ICRP, 2021). De facto, les expositions médicales semblent être exclues puisqu’elles sont délivrées à des débits de dose beaucoup plus élevés. Ainsi, l’évaluation du risque est un sujet qui doit être étudié davantage et ce sera le cas par la CIPR dans la révision du Système de protection radiologique lancée par une publication récente (Clement et al., 2021, 2022). Par ailleurs, les études épidémiologiques sur lesquelles s’appuie l’évaluation du risque présentent deux biais majeurs : (i) l’absence de prise en compte des expositions médicales additionnelles, et (ii) les associations statistiques entre le risque de développer un cancer et une exposition aux RI qui ne signifient pas qu’il existe un lien de causalité. De plus, chaque individu est exposé au cours de sa vie à une grande variété d’agents génotoxiques (exposome) dont les effets se combinent. Ainsi, retenir l’irradiation à faible dose de RI comm
在本期《辐射防护》中,Jean-Marc Cosset使用线性无阈值模型(LNT)来研究与放射治疗相关的风险评估(Cosset, 2022)。电离辐射照射所造成的风险的评估(RI)仍然是一个挑战,因为整个人口绿意介绍:主要展品包括医疗照射、天然放射性宇宙辐射乘坐长途飞机和在特殊情况下,核事故后进行展览。到目前为止,在评估随机效应(主要是癌症)的风险时,大多数国际组织倾向于国际辐射防护委员会(icrp)推荐的线性无阈值风险模型(LNT)。该模型基于有效剂量的使用,有效剂量是一种风险调整剂量量,是根据广岛-长崎原子弹幸存者长期监测的流行病学数据计算出来的,这些幸存者暴露在高剂量率下的非常高剂量(ICRP, 2007)。随后对暴露模式非常不同(不同剂量率和剂量重复)的核工作人员和患者的研究没有对该模型提出质疑,尽管它们显示了低剂量非线性(ICRP, 2021年)。然而,在评估电离辐射(ir)暴露的风险时,可归因于生命周期的风险,也考虑到未暴露的个人数据,比有效剂量更准确,特别是对妇女(ICRP, 2007;Jamshidi等人,2022)。LNT模型表明,辐照后没有诱发癌症风险的阈值,这意味着即使是非常低剂量的RI也有风险。最近,ICRP将低剂量定义为< 100mGy的器官和组织线性能量转移辐射,低剂量率定义为< 5mGy/h (ICRP, 2021)。事实上,医疗照射似乎被排除在外,因为它们的剂量率要高得多。因此,风险评估是一个需要进一步研究的课题,icrp将在最近出版的《辐射防护系统审查》(Clement et al., 2021, 2022)中对此进行研究。所依据的流行病学研究,此外,有两个重大偏差的风险评估:(i)没有考虑额外的医疗照射,并且(ii)协会的统计,患癌症风险之间的一个展览,并不意味着他的笑有因果关系。此外,每个人在一生中都暴露在各种各样的基因毒性物质(暴露体)中,这些物质的作用是综合的。因此,在累积总RI剂量仍然很低的情况下,将低剂量RI照射作为诱发癌症的唯一原因是不合理的。在Jean-Marc Cosset提出的许多问题中,有两点值得注意:如果LNT模型得到验证,“几乎所有接受放疗的患者……应该发展成辐射诱发的癌症”(Cosset, 2022);根据临床观察,情况显然并非如此;—概念的有效剂量,以mSv,涉及到全身剂量或加权平均剂量全身而剂量放疗的剂量(而且在医学诊断)是颁发给一个小研究针对肿瘤的部位或器官。
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Radioprotection
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