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Transforming organ transplantation with regenerative medicine: an interview with Giuseppe Orlando. 用再生医学转化器官移植:采访朱塞佩·奥兰多。
IF 2.4 4区 医学 Q4 CELL & TISSUE ENGINEERING Pub Date : 2024-01-01 Epub Date: 2023-11-13 DOI: 10.2217/rme-2023-0204
Giuseppe Orlando

Giuseppe Orlando is an Associate Professor of Surgery and a kidney and pancreas transplant surgeon scientist at Wake Forest University School of Medicine (Winston-Salem, North Carolina), and the President Elect of the Cell Transplant and Regenerative Medicine Society. With a research interest in bioengineering and the regeneration of transplantable organs, Giuseppe's work seeks to establish the link between transplant medicine and regenerative medicine.

Giuseppe Orlando是维克森林大学医学院(Winston-Salem, North Carolina)的外科副教授和肾脏和胰腺移植外科医生,也是细胞移植和再生医学协会的当选主席。朱塞佩的研究兴趣是生物工程和可移植器官的再生,他的工作旨在建立移植医学和再生医学之间的联系。
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引用次数: 0
Experimental and computational approach to establish fit-for-purpose cell viability assays. 通过实验和计算方法建立适用的细胞活力测定方法。
IF 2.4 4区 医学 Q4 CELL & TISSUE ENGINEERING Pub Date : 2024-01-01 Epub Date: 2024-01-22 DOI: 10.2217/rme-2023-0154
Laura Pierce, Hidayah Anderson, Swarnavo Sarkar, Steven R Bauer, Sumona Sarkar

Aim: Cell viability assays are critical for cell-based products. Here, we demonstrate a combined experimental and computational approach to identify fit-for-purpose cell assays that can predict changes in cell proliferation, a critical biological response in cell expansion. Materials & methods: Jurkat cells were systematically injured using heat (45 ± 1°C). Cell viability was measured at 0 h and 24 h after treatment using assays for membrane integrity, metabolic function and apoptosis. Proliferation kinetics for longer term cultures were modeled using the Gompertz distribution to establish predictive models between cell viability results and proliferation. Results & conclusion: We demonstrate an approach for ranking these assays as predictors of cell proliferation and for setting cell viability specifications when a particular proliferation response is required.

目的:细胞活力测定对细胞产品至关重要。在此,我们展示了一种实验与计算相结合的方法,以确定可预测细胞增殖(细胞扩增过程中的一种关键生物反应)变化的适用细胞检测方法。材料与方法使用热(45 ± 1°C)对 Jurkat 细胞进行系统损伤。处理后 0 小时和 24 小时,使用膜完整性、代谢功能和细胞凋亡测定法测量细胞活力。使用贡珀兹分布对长期培养的增殖动力学进行建模,以建立细胞存活率结果与增殖之间的预测模型。结果与结论:我们展示了一种方法,可将这些检测结果作为细胞增殖的预测指标进行排序,并在需要特定增殖反应时设定细胞存活率规格。
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引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in September 2023. 2023年9月来自干细胞研究和再生医学领域的行业更新。
IF 2.7 4区 医学 Q4 CELL & TISSUE ENGINEERING Pub Date : 2024-01-01 Epub Date: 2023-12-07 DOI: 10.2217/rme-2023-0217
Dusko Ilic, Mirjana Liovic

Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in September 2023.

根据公开信息和非学术机构新闻稿汇编的干细胞研究和再生医学领域的最新进展。
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引用次数: 0
Signal transduction pathways alter the molecular cargo of extracellular vesicles: implications in regenerative medicine. 信号转导通路改变细胞外囊泡的分子货物:在再生医学中的意义。
IF 2.4 4区 医学 Q4 CELL & TISSUE ENGINEERING Pub Date : 2023-12-01 Epub Date: 2023-12-07 DOI: 10.2217/rme-2023-0183
Prajakta Teli, Anuradha Vaidya, Vaijayanti Kale

Extracellular vesicles (EVs) possess regenerative properties and are also considered as future vaccines. All types of cells secrete EVs; however, the amount of EVs secreted by the cells varies under various physiological as well as pathological states. Several articles have reviewed the molecular composition and potential therapeutic applications of EVs. Likewise, the 'sorting signals' associated with specific macromolecules have also been identified, but how the signal transduction pathways prevailing in the parent cells alter the molecular profile of the EVs or the payload they carry has not been sufficiently reviewed. Here, we have specifically discussed the implications of these alterations in the macromolecular cargo of EVs for their therapeutic applications in regenerative medicine.

细胞外囊泡(EVs)具有再生特性,也被认为是未来的疫苗。所有类型的细胞都分泌ev;然而,在不同的生理和病理状态下,细胞分泌的ev数量是不同的。一些文章综述了ev的分子组成和潜在的治疗应用。同样,与特定大分子相关的“分类信号”也已被确定,但在亲本细胞中普遍存在的信号转导途径如何改变ev的分子特征或它们携带的有效载荷尚未得到充分的审查。在这里,我们特别讨论了电动汽车大分子货物中这些改变对其在再生医学中的治疗应用的影响。
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引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in August 2023. 2023年8月,干细胞研究和再生医学领域的行业更新。
IF 2.7 4区 医学 Q4 CELL & TISSUE ENGINEERING Pub Date : 2023-12-01 Epub Date: 2023-10-03 DOI: 10.2217/rme-2023-0181
Dusko Ilic, Mirjana Liovic

Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in August 2023.

2023年8月,根据非学术机构的公开信息和新闻稿汇编了干细胞研究和再生医学领域的最新进展。
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引用次数: 0
Improved neurological function in a patient with complete spinal cord injury through bone marrow mesenchymal stem cells implantation: a case report. 骨髓间充质干细胞移植改善完全性脊髓损伤患者神经功能1例报告。
IF 2.4 4区 医学 Q4 CELL & TISSUE ENGINEERING Pub Date : 2023-12-01 Epub Date: 2023-11-22 DOI: 10.2217/rme-2023-0120
Ying-Chuan Kuan, Shinn-Zong Lin, Tsung-Lang Chiu, Hsiang-Yi Hung

Aim: Spinal cord injury (SCI) can cause severe disability. Several clinical trials of stem-cell based therapies are ongoing. We describe our experience of bone marrow mesenchymal stem cell (BMSC) therapy in a patient with complete SCI in the chronic stage. Case report: A 25-year-old man with complete SCI at T6 level presented with paraplegia for 5 years. We transplanted autologous BMSCs intramedullary. After 12 months follow-up, his Barthel index score was noticeably improved from severe to moderate dependency, and the sensation level improved from T7 to S5, but no improvement of motor function. Conclusion: Autologous BMSCs are potentially safe for patients with complete SCI in the chronic stage and may improve neurological function and quality of life.

目的:脊髓损伤可导致严重的残疾。一些基于干细胞疗法的临床试验正在进行中。我们描述了我们的经验,骨髓间充质干细胞(BMSC)治疗患者的完全性脊髓损伤在慢性期。病例报告:一名25岁男性,完全性脊髓损伤在T6水平表现为截瘫5年。我们在髓内移植自体骨髓间充质干细胞。随访12个月后,患者Barthel指数评分由重度依赖改善至中度依赖,感觉水平由T7改善至S5,但运动功能无明显改善。结论:自体骨髓间充质干细胞对于慢性完全性脊髓损伤患者是潜在安全的,并可能改善神经功能和生活质量。
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引用次数: 0
Modern regenerative medicine dictionary: an augmented guide to biotherapy. 现代再生医学词典:生物疗法的增强指南。
IF 2.4 4区 医学 Q4 CELL & TISSUE ENGINEERING Pub Date : 2023-12-01 Epub Date: 2023-11-14 DOI: 10.2217/rme-2023-0200
Andre Terzic
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引用次数: 0
A 'one stone, two birds' approach with mesenchymal stem cells for acute respiratory distress syndrome and Type II diabetes mellitus. 利用间充质干细胞治疗急性呼吸窘迫综合征和 II 型糖尿病的 "一石二鸟 "法。
IF 2.4 4区 医学 Q4 CELL & TISSUE ENGINEERING Pub Date : 2023-12-01 Epub Date: 2023-12-19 DOI: 10.2217/rme-2023-0193
Mogesh Sababathy, Ghayathri Ramanathan, Nor Yasmin Abd Rahaman, Rajesh Ramasamy, Foo Jhi Biau, Daniel Looi Qi Hao, Nur-Fazila Saulol Hamid

This review explores the intricate relationship between acute respiratory distress syndrome (ARDS) and Type II diabetes mellitus (T2DM). It covers ARDS epidemiology, etiology and pathophysiology, along with current treatment trends and challenges. The lipopolysaccharides (LPS) role in ARDS and its association between non-communicable diseases and COVID-19 are discussed. The review highlights the therapeutic potential of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) for ARDS and T2DM, emphasizing their immunomodulatory effects. This review also underlines how T2DM exacerbates ARDS pathophysiology and discusses the potential of hUC-MSCs in modulating immune responses. In conclusion, the review highlights the multidisciplinary approach to managing ARDS and T2DM, focusing on inflammation, oxidative stress and potential therapy of hUC-MSCs in the future.

这篇综述探讨了急性呼吸窘迫综合征(ARDS)与 II 型糖尿病(T2DM)之间错综复杂的关系。内容包括 ARDS 的流行病学、病因学和病理生理学,以及当前的治疗趋势和挑战。还讨论了脂多糖(LPS)在 ARDS 中的作用及其与非传染性疾病和 COVID-19 之间的关联。综述强调了人脐带间充质干细胞(hUC-MSCs)对 ARDS 和 T2DM 的治疗潜力,强调了其免疫调节作用。这篇综述还强调了T2DM如何加剧ARDS的病理生理学,并讨论了hUC-间充质干细胞在调节免疫反应方面的潜力。最后,该综述强调了管理 ARDS 和 T2DM 的多学科方法,重点关注炎症、氧化应激和 hUC-MSCs 在未来的潜在疗法。
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引用次数: 0
Keeping an eye on sustainable regeneration. 关注可持续再生。
IF 2.4 4区 医学 Q4 CELL & TISSUE ENGINEERING Pub Date : 2023-12-01 Epub Date: 2023-08-09 DOI: 10.2217/rme-2023-0142
Meklit G Shibru, Zehara M Ali, Sumayya Alali, Hessa Alkhoori, Peter R Corridon
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引用次数: 0
Bone marrow aspirate concentrate chondroplasty to delaying need for total knee arthroplasty: a retrospective review of a veteran cohort. 骨髓浓缩软骨成形术延迟全膝关节置换术的需要:一项对退伍军人队列的回顾性回顾。
IF 2.7 4区 医学 Q4 CELL & TISSUE ENGINEERING Pub Date : 2023-11-01 Epub Date: 2023-11-21 DOI: 10.2217/rme-2023-0124
Adam Pearl, Khaled Saleh, Diana Korsog, Jeffery Mundt

Aim: Osteoarthritis (OA) is a highly prevalent and costly condition, rooted in cartilaginous defects. Despite various causes, the inability for chondrocytes to regenerate prohibits these lesions from self-healing. Debridement commonly provides symptomatic relief but does not target the underlying disease process, necessitating investigation into possible treatments. Intraosseous and intraarticular bone marrow aspirate concentrate (BMAC) injection is a new promising therapy aimed at repairing these cartilage defects. Methods/materials: We retrospectively reviewed patients who underwent BMAC chondroplasty and examined the efficacy in delaying need for further intervention. Results: Only 5 of 23 procedures (21.7%) required postoperative intervention within the 2-year follow-up period. Only one request for total knee arthroplasty was made, but the procedure has not been done. Conclusion: This study demonstrates that BMAC chondroplasty may be an efficacious method to delay need for total knee arthroplasty.

目的:骨关节炎(OA)是一种高度流行和昂贵的疾病,植根于软骨缺陷。尽管有各种各样的原因,软骨细胞无法再生阻止这些病变自愈。清创通常提供症状缓解,但不针对潜在的疾病过程,需要调查可能的治疗方法。骨内和关节内注射骨髓浓缩液(BMAC)是一种很有前途的修复软骨缺损的新方法。方法/材料:我们回顾性回顾了接受BMAC软骨成形术的患者,并检查了延迟进一步干预的疗效。结果:23例手术中仅有5例(21.7%)在2年随访期内需要术后干预。只有一个要求全膝关节置换术,但程序尚未完成。结论:本研究表明BMAC软骨成形术可能是延迟全膝关节置换术的有效方法。
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引用次数: 0
期刊
Regenerative medicine
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