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Electrospun aligned tacrolimus-loaded polycaprolactone biomaterials for peripheral nerve repair. 电纺定向他克莫司负载聚己内酯生物材料用于外周神经修复。
IF 2.4 4区 医学 Q4 CELL & TISSUE ENGINEERING Pub Date : 2024-04-01 Epub Date: 2023-10-11 DOI: 10.2217/rme-2023-0151
Holly N Gregory, Owein Guillemot-Legris, Daisy Crouch, Gareth Williams, James B Phillips

Background: Efficacious repair of peripheral nerve injury is an unmet clinical need. The implantation of biomaterials containing neurotrophic drugs at the injury site could promote nerve regeneration and improve outcomes for patients. Materials & methods: Random and aligned electrospun poly-ε-caprolactone scaffolds containing encapsulated tacrolimus were fabricated, and the gene expression profile of Schwann cells (SCs) cultured on the surface was elucidated. On aligned fibers, the morphology of SCs and primary rat neurons was investigated. Results: Both scaffold types exhibited sustained release of drug, and the gene expression of SCs was modulated by both nanofibrous topography and the presence of tacrolimus. Aligned fibers promoted the alignment of SCs and orientated outgrowth from neurons. Conclusion: Electrospun PCL scaffolds with tacrolimus hold promise for the repair of peripheral nerve injury.

背景:外周神经损伤的有效修复是一个尚未满足的临床需求。在损伤部位植入含有神经营养药物的生物材料可以促进神经再生,改善患者的预后。材料与方法:制备了含有他克莫司胶囊的随机排列的电纺聚ε-己内酯支架,并阐明了表面培养的施旺细胞的基因表达谱。在排列的纤维上,研究了SC和原代大鼠神经元的形态。结果:两种支架类型都表现出药物的持续释放,并且SCs的基因表达受到纳米纤维形貌和他克莫司的存在的调节。排列的纤维促进了SC的排列,并定向了神经元的生长。结论:他克莫司电纺PCL支架有望修复周围神经损伤。
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引用次数: 0
Animal models in peripheral nerve transection studies: a systematic review on study design and outcomes assessment. 外周神经横断研究中的动物模型:研究设计和结果评估的系统综述。
IF 2.4 4区 医学 Q4 CELL & TISSUE ENGINEERING Pub Date : 2024-04-01 Epub Date: 2023-10-19 DOI: 10.2217/rme-2023-0102
Bruna Lopes, André Coelho, Rui Alvites, Ana Catarina Sousa, Patrícia Sousa, Alícia Moreira, Luís Atayde, António Salgado, Stefano Geuna, Ana Colette Maurício

Aim: Peripheral nerve injury regeneration studies using animal models are crucial to different pre-clinical therapeutic approaches efficacy evaluation whatever the surgical technique explored. Materials & methods: A 944 articles systematic review on 'peripheral nerve injury in animal models' over the last 9 years was carried out. Results: It was found that 91% used rodents, and only 9% employed large animals. Different nerves are studied, with generated gaps (10,78 mm) and methods applied for regeneration evaluation uniformed. Sciatic nerve was the most used (88%), followed by median and facial nerves (2.6%), significantly different. Conclusion: There has not been a significant scale-up of the in vivo testing to large animal models (anatomically/physiologically closer to humans), allowing an improvement in translational medicine for clinical cases.

目的:使用动物模型进行外周神经损伤再生研究对于不同的临床前治疗方法的疗效评估至关重要,无论探索何种手术技术。材料与方法:对近9年来“动物模型中的外周神经损伤”进行了944篇系统综述。结果:91%的人使用啮齿动物,只有9%的人使用大型动物。研究了不同的神经,产生的间隙(10,78mm)和用于再生评估的方法是一致的。坐骨神经使用最多(88%),其次是正中神经和面神经(2.6%),差异显著。结论:体内测试尚未显著扩大到大型动物模型(在解剖学/生理学上更接近人类),从而改善了临床病例的转化医学。
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引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in January 2024. 2024 年 1 月干细胞研究和再生医学领域的行业动态。
IF 2.7 4区 医学 Q1 Medicine Pub Date : 2024-03-13 DOI: 10.2217/rme-2024-0034
Dusko Ilic, Mirjana Liovic

Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from nonacademic institutions in January 2024.

2024 年 1 月干细胞研究和再生医学领域的最新进展,根据公开信息和非学术机构的新闻稿汇编而成。
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引用次数: 0
The challenges and prospects of smooth muscle tissue engineering. 平滑肌组织工程的挑战与前景。
IF 2.4 4区 医学 Q4 CELL & TISSUE ENGINEERING Pub Date : 2024-03-01 Epub Date: 2024-03-05 DOI: 10.2217/rme-2023-0230
Christofer S Baldwin, Shilpa Iyer, Raj R Rao

Many vascular disorders arise as a result of dysfunctional smooth muscle cells. Tissue engineering strategies have evolved as key approaches to generate functional vascular smooth muscle cells for use in cell-based precision and personalized regenerative medicine approaches. This article highlights some of the challenges that exist in the field and presents some of the prospects for translating research advancements into therapeutic modalities. The article emphasizes the need for better developing synergetic intracellular and extracellular cues in the processes to generate functional vascular smooth muscle cells from different stem cell sources for use in tissue engineering strategies.

许多血管疾病都是由于平滑肌细胞功能失调引起的。组织工程策略已发展成为生成功能性血管平滑肌细胞的关键方法,可用于基于细胞的精准和个性化再生医学方法。本文强调了该领域存在的一些挑战,并介绍了将研究进展转化为治疗模式的一些前景。文章强调,在从不同干细胞来源生成功能性血管平滑肌细胞用于组织工程策略的过程中,需要更好地开发细胞内和细胞外协同线索。
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引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in November 2023. 2023 年 11 月干细胞研究和再生医学领域的行业动态。
IF 2.7 4区 医学 Q1 Medicine Pub Date : 2024-03-01 Epub Date: 2024-02-08 DOI: 10.2217/rme-2024-0017
Dusko Ilic, Mirjana Liovic

Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in November 2023.

2023 年 11 月干细胞研究和再生医学领域的最新进展,汇编自公开信息和非学术机构的新闻稿。
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引用次数: 0
Slaughterhouse waste: a unique and sustainable source for dECM-based bioinks. 屠宰场废物:基于 dECM 的生物墨水的独特和可持续来源。
IF 2.4 4区 医学 Q4 CELL & TISSUE ENGINEERING Pub Date : 2024-03-01 Epub Date: 2024-02-15 DOI: 10.2217/rme-2023-0194
Meklit G Shibru, Zehara M Ali, Aliyaa S Almansoori, Jovana Paunovic, Igor V Pantic, Peter R Corridon
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引用次数: 0
Bibliometric analysis of organoids in regenerative medicine-related research worldwide over two decades (2002-2022). 二十年来(2002-2022 年)全球再生医学相关研究中有机体的文献计量分析。
IF 2.4 4区 医学 Q4 CELL & TISSUE ENGINEERING Pub Date : 2024-03-01 Epub Date: 2024-03-07 DOI: 10.2217/rme-2023-0176
Jajar Setiawan, Dicky Moch Rizal, Fajar Sofyantoro, Dwi Sendi Priyono, Nur Indah Septriani, Wulan Usfi Mafiroh, Takenori Kotani, Takashi Matozaki, Wahyu Aristyaning Putri

Aim: This study aimed to evaluate the trends in organoid culture research within the field of regenerative medicine from 2002 to 2022. Methods: The worldwide distribution of organoid research in regenerative medicine articles indexed in the Scopus database was analyzed. Result: A total of 840 documents were analyzed, averaging 42 publications annually. The USA (n = 296) led in publications, followed by China (n = 127), Japan (n = 91) and the UK (n = 75). Since 2011, research has surged, particularly in China, which emerged as a prominent center. Conclusion: The findings highlight significant growth in organoid research, promising future organ transplantation. Research trends integrate tissue engineering, gene modification and induced pluripotent stem cell technologies, reflecting a move toward personalized medicine.

目的:本研究旨在评估 2002 年至 2022 年再生医学领域的类器官培养研究趋势。研究方法分析了 Scopus 数据库收录的再生医学领域类器官研究文章的全球分布情况。结果:共分析了 840 篇文献:共分析了 840 篇文献,平均每年 42 篇。美国(296 篇)的论文数量居首,其次是中国(127 篇)、日本(91 篇)和英国(75 篇)。自 2011 年以来,研究数量激增,尤其是中国,已成为一个突出的研究中心。结论研究结果凸显了类器官研究的显著增长,为未来的器官移植带来了希望。研究趋势整合了组织工程、基因修饰和诱导多能干细胞技术,反映了向个性化医学发展的趋势。
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引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in October 2023. 2023 年 10 月干细胞研究和再生医学领域的行业动态。
IF 2.7 4区 医学 Q1 Medicine Pub Date : 2024-02-01 Epub Date: 2024-02-09 DOI: 10.2217/rme-2024-0002
Dusko Ilic, Mirjana Liovic

Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in October 2023.

2023 年 10 月干细胞研究和再生医学领域的最新进展,汇编自公开信息和非学术机构的新闻稿。
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引用次数: 0
Modification of the inflammatory profile of mesenchymal stem cells using different culture conditions. 利用不同的培养条件改变间充质干细胞的炎症特征。
IF 2.4 4区 医学 Q4 CELL & TISSUE ENGINEERING Pub Date : 2024-02-01 Epub Date: 2024-02-15 DOI: 10.2217/rme-2023-0162
Alison A Smith, Charles F Bellows

Aim: Mesenchymal stem cells (MSCs) are pluripotent cells with significant therapeutic potential. The objective of this study was to examine the inflammatory profile of MSCs cultured under different conditions. Methods: MSCs were cultured by three strategies: seeding on an extracellular matrix (ECM), spheroids in static culture and spheroids in a bioreactor. Paracrine factors and CD206, a marker of M2 macrophage phenotype, were measured. Results: MSCs grown as spheroids in a bioreactor produced more IL-6 and IL-8 (p < 0.05). Supernatant collected from spheroids under both culture conditions increased the M2 macrophage phenotype almost twofold. Conclusion: Results indicate that the inflammatory profile of the supernatant collected from MSCs can be modified through culture conditions which has impacts for the future of regenerative medicine.

目的:间充质干细胞(MSCs)是具有巨大治疗潜力的多能细胞。本研究旨在检测在不同条件下培养的间充质干细胞的炎症特征。方法:通过三种策略培养间充质干细胞:在细胞外基质(ECM)上播种、静态培养球体和生物反应器中培养球体。测量旁分泌因子和 M2 巨噬细胞表型标记物 CD206。结果在生物反应器中以球形培养的间充质干细胞产生更多的IL-6和IL-8(p 结论:间充质干细胞在静态培养和生物反应器球形培养中产生的炎症特征更明显:结果表明,间充质干细胞上清液的炎症特征可通过培养条件改变,这对未来的再生医学有影响。
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引用次数: 0
Ink-spiring innovations: 3D bioprinting skin models for disease discovery. 墨水激发的创新:用于疾病发现的三维生物打印皮肤模型。
IF 2.4 4区 医学 Q4 CELL & TISSUE ENGINEERING Pub Date : 2024-02-01 Epub Date: 2024-01-05 DOI: 10.2217/rme-2023-0216
Rafaela Mayumi Simoes Torigoe, Alexander Revzin, Andrew Badley, Saranya Wyles

Tweetable abstract Inflammatory skin diseases account for most chronic skin conditions. 3D bioprinting is an exciting technology that can revolutionize the understanding and approach to treatment of atopic dermatitis and graft-versus-host disease.

Tweetable 摘要 炎症性皮肤病是大多数慢性皮肤病的病因。三维生物打印是一项令人兴奋的技术,可彻底改变对特应性皮炎和移植物抗宿主疾病的认识和治疗方法。
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Regenerative medicine
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