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A 'one stone, two birds' approach with mesenchymal stem cells for acute respiratory distress syndrome and Type II diabetes mellitus. 利用间充质干细胞治疗急性呼吸窘迫综合征和 II 型糖尿病的 "一石二鸟 "法。
IF 2.4 4区 医学 Q4 CELL & TISSUE ENGINEERING Pub Date : 2023-12-01 Epub Date: 2023-12-19 DOI: 10.2217/rme-2023-0193
Mogesh Sababathy, Ghayathri Ramanathan, Nor Yasmin Abd Rahaman, Rajesh Ramasamy, Foo Jhi Biau, Daniel Looi Qi Hao, Nur-Fazila Saulol Hamid

This review explores the intricate relationship between acute respiratory distress syndrome (ARDS) and Type II diabetes mellitus (T2DM). It covers ARDS epidemiology, etiology and pathophysiology, along with current treatment trends and challenges. The lipopolysaccharides (LPS) role in ARDS and its association between non-communicable diseases and COVID-19 are discussed. The review highlights the therapeutic potential of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) for ARDS and T2DM, emphasizing their immunomodulatory effects. This review also underlines how T2DM exacerbates ARDS pathophysiology and discusses the potential of hUC-MSCs in modulating immune responses. In conclusion, the review highlights the multidisciplinary approach to managing ARDS and T2DM, focusing on inflammation, oxidative stress and potential therapy of hUC-MSCs in the future.

这篇综述探讨了急性呼吸窘迫综合征(ARDS)与 II 型糖尿病(T2DM)之间错综复杂的关系。内容包括 ARDS 的流行病学、病因学和病理生理学,以及当前的治疗趋势和挑战。还讨论了脂多糖(LPS)在 ARDS 中的作用及其与非传染性疾病和 COVID-19 之间的关联。综述强调了人脐带间充质干细胞(hUC-MSCs)对 ARDS 和 T2DM 的治疗潜力,强调了其免疫调节作用。这篇综述还强调了T2DM如何加剧ARDS的病理生理学,并讨论了hUC-间充质干细胞在调节免疫反应方面的潜力。最后,该综述强调了管理 ARDS 和 T2DM 的多学科方法,重点关注炎症、氧化应激和 hUC-MSCs 在未来的潜在疗法。
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引用次数: 0
Keeping an eye on sustainable regeneration. 关注可持续再生。
IF 2.4 4区 医学 Q4 CELL & TISSUE ENGINEERING Pub Date : 2023-12-01 Epub Date: 2023-08-09 DOI: 10.2217/rme-2023-0142
Meklit G Shibru, Zehara M Ali, Sumayya Alali, Hessa Alkhoori, Peter R Corridon
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引用次数: 0
Bone marrow aspirate concentrate chondroplasty to delaying need for total knee arthroplasty: a retrospective review of a veteran cohort. 骨髓浓缩软骨成形术延迟全膝关节置换术的需要:一项对退伍军人队列的回顾性回顾。
IF 2.7 4区 医学 Q1 Medicine Pub Date : 2023-11-01 Epub Date: 2023-11-21 DOI: 10.2217/rme-2023-0124
Adam Pearl, Khaled Saleh, Diana Korsog, Jeffery Mundt

Aim: Osteoarthritis (OA) is a highly prevalent and costly condition, rooted in cartilaginous defects. Despite various causes, the inability for chondrocytes to regenerate prohibits these lesions from self-healing. Debridement commonly provides symptomatic relief but does not target the underlying disease process, necessitating investigation into possible treatments. Intraosseous and intraarticular bone marrow aspirate concentrate (BMAC) injection is a new promising therapy aimed at repairing these cartilage defects. Methods/materials: We retrospectively reviewed patients who underwent BMAC chondroplasty and examined the efficacy in delaying need for further intervention. Results: Only 5 of 23 procedures (21.7%) required postoperative intervention within the 2-year follow-up period. Only one request for total knee arthroplasty was made, but the procedure has not been done. Conclusion: This study demonstrates that BMAC chondroplasty may be an efficacious method to delay need for total knee arthroplasty.

目的:骨关节炎(OA)是一种高度流行和昂贵的疾病,植根于软骨缺陷。尽管有各种各样的原因,软骨细胞无法再生阻止这些病变自愈。清创通常提供症状缓解,但不针对潜在的疾病过程,需要调查可能的治疗方法。骨内和关节内注射骨髓浓缩液(BMAC)是一种很有前途的修复软骨缺损的新方法。方法/材料:我们回顾性回顾了接受BMAC软骨成形术的患者,并检查了延迟进一步干预的疗效。结果:23例手术中仅有5例(21.7%)在2年随访期内需要术后干预。只有一个要求全膝关节置换术,但程序尚未完成。结论:本研究表明BMAC软骨成形术可能是延迟全膝关节置换术的有效方法。
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引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in July 2023. 2023年7月,干细胞研究和再生医学领域的行业更新。
IF 2.7 4区 医学 Q1 Medicine Pub Date : 2023-11-01 Epub Date: 2023-09-20 DOI: 10.2217/rme-2023-0177
Dusko Ilic, Mirjana Liovic

Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in July 2023.

2023年7月,根据非学术机构的公开信息和新闻稿汇编了干细胞研究和再生医学领域的最新进展。
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引用次数: 0
Regulatory claims made by US businesses engaged in direct-to-consumer marketing of purported stem cell treatments and exosome therapies. 从事所谓干细胞治疗和外泌体疗法直接面向消费者营销的美国企业提出的监管要求。
IF 2.7 4区 医学 Q1 Medicine Pub Date : 2023-11-01 Epub Date: 2023-10-23 DOI: 10.2217/rme-2023-0117
Leigh Turner, Juan Ramon Martinez, Shemms Najjar, Thevin Rajapaksha Arachchilage, Victoria Sahrai, Jia Chieng Wang

Aim: This study investigated whether US businesses engaged in direct-to-consumer online marketing of purported stem cell therapies and stem cell-derived exosome products made claims concerning the regulatory status of these interventions. Methods: We used data mining and content analysis of company websites to examine regulatory-related representations made by US businesses marketing stem cell treatments and exosome therapies. Results: More than two thirds of such businesses did not make explicit representations about the regulatory status of their marketed products. Businesses that made claims about the regulatory status of the stem cell and exosome products they sold used range of representations concerning the legal standing of these interventions. Conclusion: The absence of information addressing the regulatory status of stem cell interventions and exosome products and the use of what appeared to be inaccurate information concerning the regulatory status of numerous products likely complicates efforts by customers to make informed health-related decisions.

目的:本研究调查了从事所谓干细胞疗法和干细胞衍生外泌体产品直接面向消费者的在线营销的美国企业是否对这些干预措施的监管状况提出了索赔。方法:我们使用数据挖掘和公司网站的内容分析来检查美国企业营销干细胞治疗和外泌体治疗的监管相关陈述。结果:超过三分之二的此类企业没有明确表示其营销产品的监管状况。声称其销售的干细胞和外泌体产品的监管状况的企业使用了一系列关于这些干预措施法律地位的陈述。结论:缺乏关于干细胞干预和外泌体产品监管状况的信息,以及使用了关于许多产品监管状况似乎不准确的信息,这可能会使客户做出知情的健康相关决策变得复杂。
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引用次数: 0
Therapeutic potential of adipose tissue derivatives in skin photoaging. 脂肪组织衍生物在皮肤光老化中的治疗潜力。
IF 2.7 4区 医学 Q1 Medicine Pub Date : 2023-11-01 Epub Date: 2023-09-25 DOI: 10.2217/rme-2023-0098
Meiqi Liu, Feng Lu, Jingwei Feng

Photoaging, the primary cause of exogenous skin aging and predominantly caused by ultraviolet radiation, is an essential type of skin aging characterized by chronic skin inflammation. Recent studies have shown that oxidative stress, inflammation, skin barrier homeostasis, collagen denaturation and pigmentation are the main contributors to it. As a composite tissue rich in matrix and vascular components, adipose tissue derivatives have been recently gaining attention as potential therapeutic agents for various human diseases with fat-processing technology upgrades. This review analyzes both 'minimally treated' and 'nonminimally treated' fat derivatives to give an overview of the preclinical and clinical relevance of adipose tissue derivatives for antiphotoaging application, highlighting their good clinical prospects as well as discussing their safety and potential risks.

光老化是外源性皮肤老化的主要原因,主要由紫外线辐射引起,是一种以慢性皮肤炎症为特征的皮肤老化的基本类型。最近的研究表明,氧化应激、炎症、皮肤屏障稳态、胶原变性和色素沉着是其主要原因。脂肪组织衍生物作为一种富含基质和血管成分的复合组织,近年来随着脂肪加工技术的升级,作为各种人类疾病的潜在治疗剂,越来越受到关注。这篇综述分析了“最小治疗”和“非最小治疗”的脂肪衍生物,概述了脂肪组织衍生物在抗衰老应用中的临床前和临床相关性,强调了它们良好的临床前景,并讨论了它们的安全性和潜在风险。
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引用次数: 0
Secretome profile of TNF-α-induced human umbilical cord mesenchymal stem cells unveils biological processes relevant to skin wound healing. TNF-α-诱导的人脐带间充质干细胞分泌组谱揭示了与皮肤伤口愈合相关的生物学过程。
IF 2.7 4区 医学 Q1 Medicine Pub Date : 2023-11-01 Epub Date: 2023-09-06 DOI: 10.2217/rme-2023-0085
Lihui Tai, Nik Syazana Saffery, Sze Piaw Chin, Soon Keng Cheong

Aim: To profile and study the proteins responsible for the beneficial effect of the TNF-α-induced human umbilical cord mesenchymal stem cells (hUCMSCs) secretome in wound healing. Methods: The hUCMSCs secretome was generated with (induced) or without (uninduced) TNF-α and was subsequently analyzed by liquid chromatography-mass spectrometry, immunoassay and in vitro scratch assay. Results: Proteomic analysis revealed approximately 260 proteins, including 51 and 55 unique proteins in the induced and uninduced secretomes, respectively. Gene ontology analysis disclosed that differential proteins in the induced secretome mainly involved inflammation-related terms. The induced secretome, consisting of higher levels of FGFb, VEGF, PDGF and IL-6, significantly accelerated wound closure and enhanced MMP-13 secretion in HaCaT keratinocytes. Conclusion: The secretome from induced hUCMSCs includes factors that promote wound closure.

目的:研究TNF-α-诱导的人脐带间充质干细胞(hUCMSCs)分泌组对创面愈合有益作用的相关蛋白。方法:用(诱导)或不(未诱导)TNF-α制备hUCMSCs分泌组,并采用液相色谱-质谱法、免疫分析法和体外划痕法进行分析。结果:蛋白质组学分析显示了大约260种蛋白质,其中诱导和未诱导分泌组中分别有51种和55种独特的蛋白质。基因本体论分析表明,诱导分泌组中的差异蛋白主要涉及炎症相关术语。诱导的分泌组由更高水平的FGFb、VEGF、PDGF和IL-6组成,显著加速了HaCaT角化细胞的伤口愈合,增强了MMP-13的分泌。结论:诱导的hUCMSCs分泌组中含有促进伤口愈合的因子。
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引用次数: 0
Microfragmented adipose tissue in the treatment of a full-thickness supraspinatus tear: a case report. 微碎脂肪组织治疗全层冈上肌撕裂:一例报告。
IF 2.7 4区 医学 Q1 Medicine Pub Date : 2023-10-01 Epub Date: 2023-09-20 DOI: 10.2217/rme-2023-0086
John L Ferrell, Alanna Dodson, Joshua Martin

A 70-year-old female presented with an 8-month history of right anterior shoulder pain and weakness, unresolved with conservative management. Among other shoulder pathology, the patient was diagnosed with a full-thickness supraspinatus tear and elected to proceed with the microfragmented adipose tissue procedure to treat the injured tendon and nearby relevant structures. Improvements in pain and function were documented along with progressive healing of the supraspinatus on ultrasound and MRI following the procedure. This case demonstrates the efficacy of microfragmented adipose tissue as a relatively novel approach to treating non-retracted, full-thickness rotator cuff tears.

一名70岁女性,有8个月的右前肩疼痛和虚弱病史,经保守治疗仍未解决。在其他肩部病理中,患者被诊断为全层冈上肌撕裂,并选择继续进行微粉碎脂肪组织手术,以治疗受伤的肌腱和附近的相关结构。手术后,超声和MRI显示疼痛和功能的改善以及冈上肌的逐渐愈合。该病例证明了微碎片脂肪组织作为一种相对较新的治疗未收缩、全厚度肩袖撕裂的方法的疗效。
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引用次数: 0
From fetal tendon regeneration to adult therapeutic modalities: TGF-β3 in scarless healing. 从胎儿肌腱再生到成人治疗模式:TGF-β3在无瘢痕愈合中的作用。
IF 2.7 4区 医学 Q1 Medicine Pub Date : 2023-10-01 Epub Date: 2023-09-06 DOI: 10.2217/rme-2023-0145
Hanyue Li, Shengyu Luo, Hongtao Li, Hongyu Pan, Li Jiang, Yixuan Chen, Hui Chen, Zhenhua Feng, Sen Li

Tendon injuries are common disorders that can significantly impact people's lives. Unfortunately, the limited regenerative ability of tendons results in tissue healing in a scar-mediated manner. The current therapeutic strategies fail to fully recover the functions of the injured tendons, and as such, the conception of 'scarless healing' has gained prominent attention in the field of regenerative medicine. Interestingly, injured fetal tendons possess the capability to heal through regeneration, which builds an ideal blueprint for adult tendon regeneration. Studies have shown that fetal biochemical cues have the potential to improve adult tendon healing. Here we review the biological factors that contribute to fetal tendon regeneration and how manipulation of these biochemical cues in the adult tendon healing process could achieve regeneration.

肌腱损伤是一种常见的疾病,会对人们的生活产生重大影响。不幸的是,肌腱有限的再生能力导致组织以瘢痕介导的方式愈合。目前的治疗策略未能完全恢复损伤肌腱的功能,因此,“无瘢痕愈合”的概念在再生医学领域受到了突出关注。有趣的是,受伤的胎儿肌腱具有通过再生愈合的能力,这为成人肌腱再生构建了理想的蓝图。研究表明,胎儿的生化信号有可能改善成人肌腱的愈合。在这里,我们回顾了有助于胎儿肌腱再生的生物学因素,以及在成人肌腱愈合过程中操纵这些生物化学线索如何实现再生。
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引用次数: 0
Safety and efficacy claims made by US businesses marketing purported stem cell treatments and exosome therapies. 营销所谓干细胞治疗和外泌体治疗的美国企业提出的安全性和有效性声明。
IF 2.7 4区 医学 Q1 Medicine Pub Date : 2023-10-01 Epub Date: 2023-10-05 DOI: 10.2217/rme-2023-0118
Leigh Turner, Juan Ramon Martinez, Shemms Najjar, Thevin Rajapaksha Arachchilage, Victoria Sahrai, Jia Chieng Wang

Aim: Examining websites of US businesses engaged in direct-to-consumer advertising of putative stem cell treatments and exosome therapies, this study investigated the marketing claims such companies make about the purported safety and efficacy of these products. Methods: Data mining and content analysis of company websites were used to identify and analyze safety and efficacy claims. Results: Of the 978 businesses analyzed, less than half the companies made identifiable claims about the safety and efficacy of their advertised stem cell and exosome products. We also explored how companies framed the stem cell and exosome products they promoted. Representations ranged from assertions that such products are unproven and investigational to claims they constituted cures. Most advertising frames fell between these poles. Conclusion: Some businesses include in their marketing representations claims about the safety and efficacy of advertised products. Businesses that did not make such assertions use other techniques to attract prospective clients.

目的:本研究调查了从事假定干细胞治疗和外泌体治疗的直接面向消费者广告的美国企业的网站,调查了这些公司对这些产品的所谓安全性和有效性的营销声明。方法:采用数据挖掘和内容分析的方法对公司网站的安全性和有效性声明进行识别和分析。结果:在分析的978家企业中,只有不到一半的公司对其广告中的干细胞和外泌体产品的安全性和有效性提出了可识别的声明。我们还探讨了公司如何构建他们推广的干细胞和外泌体产品。陈述的范围从声称这些产品未经证实和研究到声称它们构成了治疗方法。大多数广告架都落在这两根杆子之间。结论:一些企业在其营销陈述中包含了关于广告产品安全性和有效性的声明。没有做出这种断言的企业使用其他技术来吸引潜在客户。
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引用次数: 0
期刊
Regenerative medicine
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