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Statement of Retraction: The first Stem Cell-Based Tissue-Engineered Organ Replacement: Implications for Regenerative Medicine and Society. 撤回声明:首例基于干细胞的组织工程器官置换术:对再生医学和社会的影响》。
IF 2.4 4区 医学 Q4 CELL & TISSUE ENGINEERING Pub Date : 2024-10-14 DOI: 10.1080/17576180.2024.2413823
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引用次数: 0
Regeneration of full thickness common extensor tendon tear after percutaneous microfragmented adipose graft. 经皮微碎脂肪移植后全厚总伸肌腱撕裂的再生。
IF 2.4 4区 医学 Q4 CELL & TISSUE ENGINEERING Pub Date : 2024-10-10 DOI: 10.1080/17460751.2024.2393555
Imran J Siddiqui, Alyssa Ritner, Sanjay Mahadevan, Kyle J Dineen, Roosevelt Desronvilles

Tennis elbow, also commonly known as lateral epicondylitis or common extensor tendinosis, is a common musculoskeletal injury in the adult population. Currently, the standard treatment regimen prescribed for this injury involves a combination of rest, physical therapy, bracing and anti-inflammatory medications. If refractory to these conservative measures, platelet-rich plasma has been shown effective. However, in the case of full thickness tears, surgery has remained the only treatment option until now. We present a case report of a 56-year-old man with a diagnosis of a left large full thickness tear and rupture with retraction of his common extensor tendon (CET) following a corticosteroid injection. The patient was treated with microfragmented adipose transfer. He was re-evaluated around 7 weeks and again at 15 weeks post-treatment and demonstrated ultrasound evidence of complete bridging and remodeling of his prior full thickness CET tear and resolution of retraction. This case presents a promising option for patients with full thickness CET tears who would like to refrain from or are unable to have surgery. Further research and possible randomized controlled trials are needed to further assess the full efficacy of microfragmented adipose transfer in the treatment of full thickness CET tears.

网球肘俗称外上髁炎或普通伸肌腱病,是成年人常见的肌肉骨骼损伤。目前,针对这种损伤的标准治疗方案包括休息、理疗、支撑和抗炎药物。如果这些保守疗法无效,富血小板血浆已被证明有效。然而,对于全厚度撕裂的情况,手术至今仍是唯一的治疗选择。我们报告了一例 56 岁男性的病例,他在注射皮质类固醇后被诊断为左侧大面积全厚度撕裂,总伸肌腱(CET)断裂并伴有回缩。患者接受了微碎片脂肪移植治疗。他在治疗后 7 周左右和 15 周再次接受了重新评估,结果显示超声波证据表明,他之前的全厚度 CET 撕裂完全桥接和重塑,回缩也已消除。这个病例为希望避免或无法进行手术的全厚 CET 撕裂症患者提供了一个很有前景的选择。还需要进一步的研究和可能的随机对照试验,以进一步评估微碎片脂肪移植治疗全厚 CET 撕裂的全部疗效。
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引用次数: 0
Towards stem cell therapies for hearing loss: awareness and perspectives of Australian audiologists and their patients. 听力损失的干细胞疗法:澳大利亚听力学家及其患者的认识和观点。
IF 2.4 4区 医学 Q4 CELL & TISSUE ENGINEERING Pub Date : 2024-10-08 DOI: 10.1080/17460751.2024.2402650
Dysiphan Iem, Georgia Carney, Megan Munsie, Bryony A Nayagam

Aim: Over the last two decades, numerous experimental studies have examined the feasibility of delivering stem cells into the cochlea to restore hearing. While these studies have spawned new cell therapy companies, there is little information on what patients understand or expect from these emerging therapies.Methods: This study sought to understand the awareness and perspectives of Australian audiologists and their adult patients toward stem cell therapies for treating hearing loss.Results: An anonymous survey indicated 91% of patients and 39% of audiologists were unaware of these therapies being developed. Thirty percent of audiologists reported being asked about stem cell therapies for hearing loss, but 70% were not confident answering patient queries about this and were unsure where to gather information. Primary concerns reported by patients were cost (45%) and safety of treatment (42%). Interestingly, 58% of patients were unsure of how this therapy would improve their hearing, yet 25% of these patients expected that their hearing would return to normal.Conclusion: There was strong support for development of educational materials for both patient and clinician. The increasingly important role of audiologists in providing patient counselling was reflected in overwhelming support (from both patient and clinician) for audiologists providing such information.

目的:在过去二十年中,大量实验研究探讨了向耳蜗输送干细胞以恢复听力的可行性。虽然这些研究催生了新的细胞疗法公司,但有关患者对这些新兴疗法的理解或期望的信息却很少:本研究旨在了解澳大利亚听力学家及其成年患者对干细胞疗法治疗听力损失的认识和看法:一项匿名调查显示,91%的患者和39%的听力学家不知道这些疗法正在开发中。30%的听力学家表示曾被问及治疗听力损失的干细胞疗法,但70%的听力学家没有信心回答患者的相关询问,也不知道从哪里收集信息。患者主要担心的是费用(45%)和治疗的安全性(42%)。有趣的是,58% 的患者不确定这种疗法会如何改善他们的听力,但其中 25% 的患者期望他们的听力会恢复正常:结论:为患者和临床医生编写教育材料得到了强烈支持。听力学家在为患者提供咨询方面发挥着越来越重要的作用,这反映在听力学家提供此类信息得到了绝大多数患者和临床医生的支持。
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引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in June 2024. 2024 年 6 月干细胞研究和再生医学领域的行业动态。
IF 2.4 4区 医学 Q4 CELL & TISSUE ENGINEERING Pub Date : 2024-09-17 DOI: 10.1080/17460751.2024.2393560
Dusko Ilic, Mirjana Liovic

Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in June 2024.

2024 年 6 月干细胞研究和再生医学领域的最新进展,汇编自公开信息和非学术机构的新闻稿。
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引用次数: 0
Induced pluripotent stem cell therapies in heart failure treatment: a meta-analysis and systematic review. 诱导多能干细胞疗法在心力衰竭治疗中的应用:荟萃分析和系统综述。
IF 2.4 4区 医学 Q4 CELL & TISSUE ENGINEERING Pub Date : 2024-09-12 DOI: 10.1080/17460751.2024.2393558
Duy Cao Phuong Le, Hoa The Bui, Yen Thi Hai Vu, Quan Duy Vo

Background: Heart failure (HF) causes over 266,400 deaths annually. Despite treatment advancements, HF mortality remains high. Induced pluripotent stem cells (iPSCs) offer promising new options. This review assesses iPSC-based treatments for HF.Method: the review included studies from PubMed, ScienceDirect and Web of Science.Results: Analysis of 25 studies with 553 animals showed a baseline ejection fraction (EF) of 39.2 ± 8.9%. iPSC treatment significantly improved EF (MD = 8.6, p < 0.001) and fractional shortening (MD = 6.38, p < 0.001), and reduced ventricular remodeling without increasing arrhythmia risk.Conclusion: iPSC-based therapy improves heart function and reduces ventricular volumes in HF animal models, aligning with promising early clinical trial outcomes.

背景:心力衰竭(HF)每年导致超过 266,400 人死亡。尽管治疗取得了进展,但心力衰竭的死亡率仍然很高。诱导多能干细胞(iPSC)提供了有希望的新选择。本综述评估了基于iPSC的HF治疗方法。方法:综述包括来自PubMed、ScienceDirect和Web of Science的研究:iPSC治疗可显著改善射血分数(MD = 8.6,p p 结论:基于iPSC的疗法可改善HF动物模型的心脏功能并减少心室容积,这与早期临床试验结果一致。
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引用次数: 0
Evaluation of bi-layer silk fibroin grafts for onlay urethroplasty in a rabbit model of urethral stricture disease. 在兔尿道狭窄疾病模型中评估双层丝纤维蛋白移植物用于尿道嵌顿成形术的效果。
IF 2.4 4区 医学 Q4 CELL & TISSUE ENGINEERING Pub Date : 2024-08-30 DOI: 10.1080/17460751.2024.2389753
Gokhan Gundogdu, Jay Budrewicz, Jodie Giordano, Raffaele Melidone, Chris Searcy, Vikas Agarwal, Carlos R Estrada, Joshua R Mauney

Background: Autologous tissues such as buccal mucosa (BM) are widely used for reconstruction of urethral strictures; however, limitations such as donor site morbidity and scarce tissue supply require the development of alternative biomaterials for urethral repair. The goals of this study were to determine the safety and efficacy of bi-layer silk fibroin (BLSF) matrices for urethral stricture repair and compare histological and functional outcomes to the standard approach, BM urethroplasty under good laboratory practices.Material and methods: A total of 13 rabbits exhibiting urethral stricture formation following electrocoagulation injury were treated with onlay urethroplasty with either acellular BLSF (N = 7) or autologous BM (N = 6) grafts for 3 months. Uninjured control rabbits were maintained in parallel (N = 4).Results and conclusion: Animals receiving BLSF implants were demonstrated to be functionally equivalent to BM grafts in their ability to restored strictured calibers, support micturition and promote tissue regeneration with minimal inflammation.

背景:颊粘膜(BM)等自体组织被广泛用于尿道狭窄的重建;然而,由于供体部位发病率和组织供应稀缺等限制,需要开发用于尿道修复的替代生物材料。本研究的目的是确定双层蚕丝纤维蛋白(BLSF)基质用于尿道狭窄修复的安全性和有效性,并将组织学和功能结果与标准方法--良好实验室规范下的 BM 尿道成形术--进行比较:共对 13 只电凝损伤后尿道狭窄的兔子进行了为期 3 个月的无细胞 BLSF(7 只)或自体 BM(6 只)移植物尿道成形术。同时饲养未受伤的对照组兔子(4 只):结果和结论:接受 BLSF 植入物的动物在功能上与 BM 移植物相当,它们能够恢复狭窄的管径、支持排尿并促进组织再生,同时炎症极少。
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引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in May 2024. 2024 年 5 月干细胞研究和再生医学领域的行业动态。
IF 2.4 4区 医学 Q4 CELL & TISSUE ENGINEERING Pub Date : 2024-08-05 DOI: 10.1080/17460751.2024.2378634
Dusko Ilic, Mirjana Liovic

Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in May 2024.

2024 年 5 月干细胞研究和再生医学领域的最新进展,汇编自公开信息和非学术机构的新闻稿。
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引用次数: 0
Advances in regenerative rehabilitation in the rehabilitation of musculoskeletal injuries. 再生康复在肌肉骨骼损伤康复方面的进展。
IF 2.4 4区 医学 Q4 CELL & TISSUE ENGINEERING Pub Date : 2024-06-02 Epub Date: 2024-06-10 DOI: 10.1080/17460751.2024.2357956
Zirui Zhang, Pengfei Yao, Shuai Fan

In the rapidly advancing field of regenerative medicine, relying solely on cell transplantation alone may be insufficient for achieving functional recovery, and rehabilitation before and after transplantation is crucial. Regenerative rehabilitation functions by synergizing the therapeutic effects of regeneration and rehabilitation to maximize tissue regeneration and patient function. We used the keywords "regenerative rehabilitation" to search across the database for published works; this review discusses the development of regenerative rehabilitation for the treatment of musculoskeletal injuries. Rehabilitation has become a crucial component of regenerative medicine because it can enhance patients' functional activity and facilitate their early return to society. Experimental data increasingly demonstrates that rehabilitation interventions support the regeneration of transplanted tissues.

在快速发展的再生医学领域,仅仅依靠细胞移植可能不足以实现功能恢复,移植前后的康复治疗至关重要。再生康复的作用是将再生和康复的治疗效果协同起来,最大限度地提高组织再生和患者功能。我们使用关键词 "再生康复 "在数据库中搜索已发表的作品;本综述讨论了再生康复在治疗肌肉骨骼损伤方面的发展。康复已成为再生医学的重要组成部分,因为它能增强患者的功能活动,促进他们早日重返社会。越来越多的实验数据表明,康复干预有助于移植组织的再生。
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引用次数: 0
Facilitating the ethical sourcing of donor hematopoietic stem cells for cell and gene therapy research and development. 为细胞和基因疗法的研究与开发提供符合道德标准的造血干细胞捐献来源。
IF 2.4 4区 医学 Q4 CELL & TISSUE ENGINEERING Pub Date : 2024-06-02 Epub Date: 2024-06-18 DOI: 10.1080/17460751.2024.2357930
Lina Hamad, Choon Key Chekar, Chloe Anthias, Laura Machin

Aim: Unrelated stem cell donor registries (DRs) are increasingly engaging in the field of cell and gene therapy (CGT). This study aims to explore the values, concerns, needs and expectations of donors and members of the public on donating hematopoietic stem cells (HSCs) for CGT.Methods: Seven focus groups were conducted in 2019 with members of the public, prospective donors and donors on the Anthony Nolan DR in the UK.Results: Participants expressed concerns over increased frequency of donation and incidental findings and required more information on the type of research including the purpose and possible outcomes.Conclusion: Addressing donors' concerns, needs and expectations on donating cellular materials for CGT research and development is essential to maintaining the highest standards for donor care and safety within this rapidly emerging field.

目的:非亲缘干细胞捐献者登记处(DRs)越来越多地参与到细胞和基因治疗(CGT)领域。本研究旨在探讨捐献者和公众对捐献造血干细胞用于细胞和基因治疗的价值观、关注点、需求和期望。研究方法于2019年与公众、潜在捐献者和英国安东尼诺兰DR的捐献者开展了七次焦点小组讨论。结果参与者对捐赠频率增加和偶然发现表示担忧,并要求获得更多有关研究类型的信息,包括目的和可能的结果。结论:解决捐献者对捐献细胞材料用于 CGT 研究和开发的担忧、需求和期望,对于在这一迅速崛起的领域保持最高标准的捐献者护理和安全至关重要。
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引用次数: 0
PXL01 alters macrophage response with no effect on axonal outgrowth or Schwann cell response after nerve repair in rats. PXL01 可改变巨噬细胞的反应,但对大鼠神经修复后的轴突生长或许旺细胞反应没有影响。
IF 2.4 4区 医学 Q4 CELL & TISSUE ENGINEERING Pub Date : 2024-06-02 Epub Date: 2024-07-03 DOI: 10.1080/17460751.2024.2361515
Derya Burcu Hazer Rosberg, Lena Stenberg, Margit Mahlapuu, Lars B Dahlin

Background: Adjunctive pharmacological treatment may improve nerve regeneration. We investigated nerve regeneration processes of PXL01 - a lactoferrin-derived peptide - after repair of the sciatic nerve in healthy Wistar rats.Materials & methods: PXL01, sodium hyaluronate (carrier) or sodium chloride was administered around the repair. After 6 days axonal outgrowth, Schwann cell response, pan- (CD68) and pro-healing (CD206) macrophages in sciatic nerve, sensory neuronal response in dorsal root ganglia (DRG) and expression of heat shock protein 27 (HSP27) in sciatic nerves and DRGs were analyzed.Results: Despite a lower number of pan-macrophages, other investigated variables in sciatic nerves or DRGs did not differ between the treatment groups.Conclusion: PLX01 applied locally inhibits inflammation through pan-macrophages in repaired sciatic nerves without any impact on nerve regeneration or pro-healing macrophages.

背景:辅助药物治疗可改善神经再生。我们研究了乳铁蛋白衍生肽 PXL01 在健康 Wistar 大鼠坐骨神经修复后的神经再生过程。材料与方法:在修复处周围注射 PXL01、透明质酸钠(载体)或氯化钠。6 天后,分析坐骨神经的轴突生长、许旺细胞反应、泛(CD68)和促愈合(CD206)巨噬细胞、背根神经节(DRG)的感觉神经元反应以及坐骨神经和 DRG 的热休克蛋白 27(HSP27)表达。结果:尽管泛巨噬细胞的数量较少,但坐骨神经或背根神经节的其他研究变量在治疗组之间没有差异。结论局部应用 PLX01 可通过修复的坐骨神经中的泛巨噬细胞抑制炎症,而不会影响神经再生或促进愈合的巨噬细胞。
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引用次数: 0
期刊
Regenerative medicine
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