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Astragaloside-IV induces the differentiation of bone marrow mesenchymal stem cells into osteoblasts through NMUR2-mediated Wnt/β-catenin pathway. 黄芪甲苷通过nmur2介导的Wnt/β-catenin通路诱导骨髓间充质干细胞向成骨细胞分化。
IF 2.7 4区 医学 Q4 CELL & TISSUE ENGINEERING Pub Date : 2023-06-01 DOI: 10.2217/rme-2022-0184
Yujing Cao, Qiuxia Lv, Zhihui Huang, Yang Li

Aim: Given that astragaloside-IV (As-IV) has the ability to promote osteogenic differentiation, its mechanism is worthy of exploration. Methods: The effect of As-IV on rat tibial defects was examined by histopathological staining and MiR-CT scan. The alkaline phosphatase (ALP) content, osteogenic differentiation-related gene expressions, and mineralized nodule formation in bone marrow mesenchymal stem cells (BMSCs) were detected. Results: As-IV repaired tibial defects of rats. As-IV or neuromedin receptor 2 (NMUR2) overexpression elevated ALP content, mineralized nodules, osteogenic differentiation-related genes, β-catenin and NMUR2 levels, the effects of which were reversed by NMUR2 silencing or Wnt/β-catenin pathway inhibitors. Conclusion: As-IV regulates the Wnt/β-catenin pathway through NMUR2 to promote the repair of tibial defects in rats and the differentiation of BMSCs into osteoblasts.

目的:黄芪甲苷(astragaloside-IV, As-IV)具有促进成骨分化的能力,其机制值得探讨。方法:采用组织病理学染色和MiR-CT扫描检测As-IV对大鼠胫骨缺损的影响。检测骨髓间充质干细胞(BMSCs)碱性磷酸酶(ALP)含量、成骨分化相关基因表达及矿化结节形成。结果:As-IV修复大鼠胫骨缺损。As-IV或神经medin受体2 (NMUR2)过表达升高ALP含量、矿化结节、成骨分化相关基因、β-catenin和NMUR2水平,这些作用可通过NMUR2沉默或Wnt/β-catenin途径抑制剂逆转。结论:As-IV通过NMUR2调控Wnt/β-catenin通路,促进大鼠胫骨缺损修复及BMSCs向成骨细胞分化。
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引用次数: 0
Pseudoseptic reaction to an intra-articular platelet-rich plasma injection into the knee: a case report. 膝关节内关节内富血小板血浆注射的假性化脓性反应:1例报告。
IF 2.7 4区 医学 Q4 CELL & TISSUE ENGINEERING Pub Date : 2023-06-01 DOI: 10.2217/rme-2022-0216
Kyungje Sung, Kevin Zheng, Chris Williams, David Cunningham, Walter I Sussman

A variety of intra-articular injections are used for the management of osteoarthritis. A rare complication of intra-articular injections is acute pseudoseptic arthritis, which mimics true septic arthritis. To the authors knowledge, pseudosepsis has not been reported as a complication after platelet-rich plasma (PRP) injections. We present a case report of pseudoseptic arthritis resulting in acute postinjection pain and a joint effusion after an intra-articular PRP injection into the knee. Clinically, pseudosepsis can occur after PRP treatment with significantly elevated white blood cell counts in the synovial fluid, and should be a consideration in cases of post-PRP injection flares.

各种关节内注射用于骨关节炎的治疗。关节内注射的一个罕见的并发症是急性假性脓毒性关节炎,它模仿真正的脓毒性关节炎。据作者所知,假性败血症尚未报道为富血小板血浆(PRP)注射后的并发症。我们提出一个病例报告的假性化脓性关节炎导致急性注射后疼痛和关节积液后,关节内PRP注射到膝盖。临床上,假性脓毒症可发生在PRP治疗后,滑液中白细胞计数明显升高,在PRP注射后出现耀斑的情况下应予以考虑。
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引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in February 2023. 2023年2月来自干细胞研究和再生医学领域的行业更新。
IF 2.7 4区 医学 Q4 CELL & TISSUE ENGINEERING Pub Date : 2023-06-01 DOI: 10.2217/rme-2023-0053
Dusko Ilic, Mirjana Liovic
Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in February 2023.
根据公开信息和非学术机构的新闻稿汇编的干细胞研究和再生医学领域的最新进展。
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引用次数: 0
Derivation of a clinical decision rule for a bone marrow aspirate concentrate injection in knee osteoarthritis. 骨髓浓缩液注射治疗膝骨关节炎的临床决策规则的推导。
IF 2.7 4区 医学 Q4 CELL & TISSUE ENGINEERING Pub Date : 2023-06-01 DOI: 10.2217/rme-2023-0014
Ashley D Smith, Dasan Sydora, Robert Burnham

Aim: To develop a simple clinical decision rule (CDR) to identify people with knee osteoarthritis who are likely or unlikely to benefit from bone marrow aspirate concentrate (BMAC) injection. Materials & methods: A total of 92 people with clinical and radiographic evidence of refractory knee osteoarthritis received a single intra-articular (IA) BMAC injection. Multiple logistic regression analysis was used to determine which combination of risk factors predicted BMAC responsiveness. A responder was defined as a person whose knee pain improved more than 15% from baseline 6 months post procedure. Results: The CDR demonstrated that those with lower pain levels, or high pain levels with previous surgery, could be predicted to benefit from a single IA BMAC injection. Conclusion: A simple CDR containing three variables predicted responsiveness to a single IA knee BMAC injection with high accuracy. Further validation of the CDR is required prior to routine use in clinical practice.

目的:建立一个简单的临床决策规则(CDR),以确定谁可能或不可能受益于骨髓浓缩物(BMAC)注射的膝骨关节炎患者。材料与方法:共有92例具有临床和影像学证据的难治性膝骨性关节炎患者接受单次关节内(IA) BMAC注射。采用多元logistic回归分析确定哪些危险因素组合可预测BMAC反应性。应答者定义为术后6个月膝关节疼痛较基线改善15%以上的患者。结果:CDR显示,疼痛程度较低或既往手术疼痛程度较高的患者可以从单次IA BMAC注射中获益。结论:一个包含三个变量的简单CDR预测对单次IA膝关节BMAC注射的反应性具有很高的准确性。在临床常规使用之前,需要对CDR进行进一步的验证。
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引用次数: 0
Efficacy of platelet-rich plasma for sacroiliac joint dysfunction: a qualitative systematic review with pooled analysis. 富血小板血浆治疗骶髂关节功能障碍的疗效:一项综合分析的定性系统评价。
IF 2.7 4区 医学 Q4 CELL & TISSUE ENGINEERING Pub Date : 2023-06-01 DOI: 10.2217/rme-2022-0211
Brandon Goodwin, Nicholas Averell, Usmaan Al-Shehab, Akhmad Ernazarov, Lisa Price, Akhil Choudhary, Richard Jermyn

Aim: We aimed to expound upon previous research examining the effect of platelet rich plasma in the treatment of sacroiliac joint (SIJ) dysfunction and pain. Materials & methods: A systematic review was employed in conjunction with a pooled analysis of the efficacy of platelet-rich plasma (PRP) in SIJ dysfunction and pain. Results: A total of 259 articles were retrieved following database systematic review. As a result, four clinical trials and two case studies were subjected to full text appraisal. The dates of publication ranged from 2015 to 2022. Conclusion: Although a unique modality, there is not enough evidence to support the employment of PRP injections over current steroid standard of care. Further double-blinded, randomized control trials are required to elucidate PRP role in SIJ dysfunction.

目的:对富血小板血浆治疗骶髂关节(SIJ)功能障碍和疼痛的疗效进行综述。材料与方法:系统回顾并汇总分析富血小板血浆(PRP)治疗SIJ功能障碍和疼痛的疗效。结果:经数据库系统审查,共检索到259篇文献。因此,对四项临床试验和两项案例研究进行了全文评估。出版日期从2015年到2022年不等。结论:虽然是一种独特的治疗方式,但没有足够的证据支持PRP注射优于目前的类固醇治疗标准。需要进一步的双盲、随机对照试验来阐明PRP在SIJ功能障碍中的作用。
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引用次数: 1
Critical elements in tissue engineering of craniofacial malformations. 颅面畸形组织工程的关键因素。
IF 2.7 4区 医学 Q4 CELL & TISSUE ENGINEERING Pub Date : 2023-06-01 DOI: 10.2217/rme-2022-0128
Ali Gholamalizadeh, Sajed Nazifkerdar, Nasim Safdarian, Aida Eyvaz Ziaee, Hamid Mobedi, Reza Rahbarghazi, Mehdi Khanmohammadi, Sepideh Saghati

Abnormal craniofacial bone fusion can lead to the generation of several congenital malformations such as cleft palate, craniosynostosis and craniofacial skeletal hypoplasia, which physically and mentally affect patients. Conventional approaches for the treatment of craniofacial malformations such as the transplantation of autologous bone grafts are not completely efficient and usually, patients suffer from various complications. In line with these statements, the advent of novel therapeutic approaches in human medicine is mandatory. Regarding the extent, size and severity of the bone malformation, supplementation and release of oxygen molecules into the affected sites are critical issues for successful osteogenesis. Here, tissue engineering modalities associated with oxygen supplementation and novel approaches associated with hydrogel synthesis were highlighted in terms of craniofacial malformations.

颅面骨融合异常可导致腭裂、颅缝闭锁、颅面骨发育不全等几种先天性畸形的产生,对患者身心造成影响。传统的颅面畸形治疗方法如自体骨移植并不完全有效,而且患者通常会出现各种并发症。与这些声明一致,人类医学中出现新的治疗方法是强制性的。考虑到骨畸形的程度、大小和严重程度,氧分子的补充和释放是成功成骨的关键问题。在颅面畸形方面,强调了与氧气补充相关的组织工程模式和与水凝胶合成相关的新方法。
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引用次数: 0
Association of mesenchymal stem cells derived from bone marrow and adipose tissue enhances bone repair in rat calvarial defects. 骨髓间充质干细胞与脂肪组织的结合促进了大鼠颅骨缺损的骨修复。
IF 2.7 4区 医学 Q4 CELL & TISSUE ENGINEERING Pub Date : 2023-05-01 DOI: 10.2217/rme-2022-0219
Gabriela Guaraldo Campos Totoli, Rayana Longo Bighetti-Trevisan, Gileade Pereira Freitas, Leticia Faustino Adolpho, Adriana Luisa Golçalves Almeida, Ana Carolina Loyola Barbosa, Jaqueline Isadora Reis Ramos, Marcio Mateus Beloti, Adalberto Luiz Rosa

Aim: We evaluated the bone repair induced by MSCs from adipose tissue (AT-MSCs) and bone marrow (BM-MSCs) injected into rat calvarial defects at two time points. Methods & results: Both cell populations expressed MSC surface markers and differentiated into adipocytes and osteoblasts. μCT showed that the combination of cells from distinct sources exhibited synergistic effects to increase bone repair with an advantage when BM-MSCs were injected prior to AT-MSCs. The higher osteogenic potential of these MSC combinations was demonstrated using an in vitro coculture system where BM-MSCs and AT-MSCs association induced higher ALP activity in MC3T3-E1 cells. Conclusion: Our findings may drive new approaches to treat bone defects and shed light on the complexity of the mechanisms involved in bone regeneration.

目的:观察脂肪组织间充质干细胞(at -MSCs)和骨髓间充质干细胞(BM-MSCs)在两个时间点对大鼠颅骨缺损的骨修复作用。方法与结果:两组细胞均表达MSC表面标记,并分化为脂肪细胞和成骨细胞。μCT结果显示,不同来源的细胞组合在促进骨修复方面表现出协同效应,且在AT-MSCs之前注射BM-MSCs具有优势。在体外共培养系统中,BM-MSCs和AT-MSCs联合诱导MC3T3-E1细胞中更高的ALP活性,证明了这些MSC组合具有更高的成骨潜能。结论:我们的发现可能会推动治疗骨缺损的新方法,并揭示骨再生机制的复杂性。
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引用次数: 2
Expanding the manufacturing capacity for cell and gene therapies: an interview with Julie G Allickson. 扩大细胞和基因疗法的生产能力:采访 Julie G Allickson。
IF 2.7 4区 医学 Q4 CELL & TISSUE ENGINEERING Pub Date : 2023-05-01 Epub Date: 2023-05-11 DOI: 10.2217/rme-2023-0057
Julie G Allickson

Julie G Allickson, PhD, is the Michael S and Mary Sue Shannon Family Director of Mayo Clinic's Center for Regenerative Biotherapeutics at Mayo Clinic (Minnesota, Florida and Arizona) and the Otto Bremer Trust Director, Biomanufacturing and Product Development, Center for Regenerative Biotherapeutics. With over 25 years of experience in regenerative medicine, cellular therapies and regulatory affairs, Dr Allickson leads the center as it pivots toward biomanufacturing, ensuring that discoveries are successful for clinical translation and eventually commercialization. The center is in the process of building their industry experienced team on all pillars of biomanufacturing to support clinical and principal investigators at the Mayo Clinic.

Julie G Allickson 博士是梅奥诊所(明尼苏达州、佛罗里达州和亚利桑那州)梅奥诊所再生生物治疗中心的迈克尔-S 和玛丽-苏-香农家族主任,也是再生生物治疗中心生物制造和产品开发奥托-布雷默信托主任。Allickson博士在再生医学、细胞疗法和监管事务方面拥有超过25年的经验,他领导该中心转向生物制造,确保新发现能够成功地应用于临床,并最终实现商业化。该中心正在组建一支行业经验丰富的团队,负责生物制造的所有支柱工作,为梅奥诊所的临床研究人员和主要研究人员提供支持。
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引用次数: 0
Lateral epicondylitis: comparing ultrasound-guided tenotomy with or without amniotic membrane allograft injection. 外侧上髁炎:超声引导下的肌腱切开术与不注射同种异体羊膜的比较。
IF 2.7 4区 医学 Q4 CELL & TISSUE ENGINEERING Pub Date : 2023-05-01 DOI: 10.2217/rme-2023-0027
Hirotaka Nakagawa, Kyungje Sung, Ken Mautner, Tabitha May, Walter I Sussman

Aim: To evaluate the clinical response to augmenting ultrasound-guided tenotomy (USGT) with an amniotic membrane (AM) allograft injection. Design: Retrospective study. Materials & methods: Subjects underwent either a USGT (N = 16) or a combined USGT plus AM injection (N = 14). Results: Both groups demonstrated a significant reduction in pain from baseline starting after 2 weeks in the USGT plus AM group (p = 0.036) and after 8 weeks in the USGT group (p = 0.021). The reduction in pain was sustained for the entire duration of the study (52 weeks). There was no significant difference in pain levels at 26- or 52-week follow-up or patient satisfaction between the two groups. Conclusion: USGT with or without AM allograft injections results in a significant reduction in pain with high patient satisfaction.

目的:评价超声引导下羊膜(AM)增强肌腱切开术(USGT)的临床疗效。设计:回顾性研究。材料与方法:受试者接受了USGT (N = 16)或USGT加AM注射(N = 14)。结果:两组疼痛均在USGT + AM组2周后(p = 0.036)和USGT组8周后(p = 0.021)从基线开始显著减轻。疼痛的减轻持续了整个研究期间(52周)。在26周或52周的随访中,两组患者的疼痛程度和患者满意度没有显著差异。结论:采用同种异体AM移植注射或不采用同种异体AM移植注射可显著减轻疼痛,患者满意度高。
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引用次数: 0
Industry updates from the field of stem cell research and regenerative medicine in January 2023. 2023年1月干细胞研究和再生医学领域的行业更新。
IF 2.7 4区 医学 Q4 CELL & TISSUE ENGINEERING Pub Date : 2023-05-01 DOI: 10.2217/rme-2023-0045
Dusko Ilic, Mirjana Liovic

Latest developments in the field of stem cell research and regenerative medicine compiled from publicly available information and press releases from non-academic institutions in January 2023.

根据公开信息和非学术机构新闻稿汇编的干细胞研究和再生医学领域的最新进展。
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引用次数: 0
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Regenerative medicine
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