Reviews on Environmental Health最新文献

The gastrointestinal (GI) system has rapidly proliferating and differentiating cells, which make it one of the most radiosensitive organs in the body. Exposure to high dose of ionising radiation (IR) during radiotherapy may generate a variety of reactive oxygen species (ROS) and reactive nitrogen species (RNS) including radicals, cause some side effects such as nausea, vomiting, diarrhoea, pain, ulceration, mal-absorption etc. Irradiation disrupts GI system by damaging proliferating stem cells of the crypts that alters the histology and physiology of intestine. Radiation damage reflects the qualitative and quantitative changes in intestinal epithelial stem cells like enterocytes, enteroendocrine cells, goblet cells and Paneth cells. The damaging effects of radiation to bio-molecules and cellular structures can alter gene signalling cascades and grounds genomic instability, protein modifications, cell senescence and cell death. The signalling pathways of GI tract includes Wnt, BMP, Hedgehog, PTEN/PI3K and Notch plays an important role in self-renewal of intestinal stem cells (ISCs) and maintaining the balance between self-renewal and differentiation of ISCs. Various radiation countermeasures including radioprotectors and mitigators are under development phase globally but still not approved for clinical applications during any radiation emergencies. In view of above, present review highlights cellular and molecular interruptions of GI system due to acute and chronic GI radiation injury, role of radioprotectors in signalling cascade modulations in GI epithelium and involvement of ISC markers in radioprotection.

Traveling to high altitudes for entertainment or work is sometimes associated with acute high altitude pathologies. In the past, scientific literature from the lowlander point of view was primarily based on mountain climbing. Sea level scientists developed all guidelines, but they need modifications for medical care in high altitude cities. Acute Mountain Sickness, High Altitude Pulmonary Edema, and High Altitude Cerebral Edema are medical conditions that some travelers can face. We present how to diagnose and treat acute high altitude pathologies, based on 51 years of high altitude physiology research and medical practice in hypobaric hypoxic diseases in La Paz, Bolivia (3,600 m; 11,811 ft), at the High Altitude Pulmonary and Pathology Institute (HAPPI - IPPA). These can occasionally present after flights to high altitude cities, both in lowlanders or high-altitude residents during re-entry. Acute high altitude ascent diseases can be adequately diagnosed and treated in high altitude cities following the presented guidelines. Treating these high-altitude illnesses, we had no loss of life. Traveling to a high altitude with sound medical advice should not be feared as it has many benefits. Nowadays, altitude descent and evacuation are not mandatory in populated highland cities, with adequate medical resources.

A previously healthy worker developed symptoms assigned to electromagnetic hypersensitivity (EHS) after moving to an office with exposure to high levels of anthropogenic electromagnetic fields (EMFs). These symptoms consisted of e.g. headache, arthralgia, tinnitus, dizziness, memory loss, fatique, insomnia, transitory cardiovascular abnormalities, and skin lesions. Most of the symptoms were alleviated after 2 weeks sick leave. The highest radiofrequency (RF) field level at the working place was 1.72 V/m (7,852 μW/m²). Maximum value for extremely low frequency electromagnetic field (ELF-EMF) from electric power at 50 Hz was measured to 285 nT (mean 241 nT). For electric train ELF-EMF at 16.7 Hz was measured to 383 nT (mean 76 nT). Exposure to EMFs at the working place could be the cause for developing EHS related symptoms. The association was strengthened by the symptom reduction outside the working place.

Most agricultural products are exposed to pesticides. Organochlorine (OCPs) insecticides have been banned for years due to their persistence in the environment and lipophilic properties. On the other hand, some carcinogenic organophosphates are used in high amounts. Therefore, this systematic review was performed with the keywords; pesticide, carcinogenic, carcinogen, residue, contamination, pollution, and food to determine the type of food and pesticide. 663 manuscripts were found by searching in databases. After initial screening and quality assessment of full text, 26 manuscripts were selected. In this study, by reviewing selected manuscripts, about 13 pesticides were associated with carcinogenic effects. These pesticides were Chlorothalonil, Glyphosate, Tetrachlorvinphos, Parathion, Malathion, Diazinon, heptachlor, Hexachlorobenzene, aldrin, dieldrin, DDT, chlordane, Lindane. Most of these pesticides were organochlorine. The organochlorine pesticides are primarily detected in foods of animal origin. In some studies, the amount of carcinogenic organochlorine was higher than the permissible levels. From the carcinogenic herbicide, Glyphosate. An important finding of this systematic review is that carcinogenic organochlorines are still a threat to cancer incidence.

The presence of trace elements such as lithium (Li) in water resources in the long term can endanger consumers' health. Several studies have been conducted on Li concentration in water sources; hence, this study attempted to retrieve studies using a systematic search. The search was conducted in Web of Sciences, Embase, PubMed, and Scopus databases from 1 January 2010 to 15 January 2023. Li concentration was meta-analyzed based on the type of water resources and countries subgroups in the random effects model (REM) statistical analysis. In addition, health risk assessment in different age groups was calculated using the target hazard quotient (THQ). This study included 76 papers with 157 data reports in our meta-analysis. The overall pooled concentration of Li was 5.374 (95 % CI: 5.261-5.487 μg/L). The pooled concentration of Li in groundwater (40.407 μg/L) was 14.53 times surface water (2.785 μg/L). The highest water Li content was attributed to Mexico (2,209.05 μg/L), Bolivia (1,444.05 μg/L), Iraq (1,350 μg/L), and Argentina (516.39 μg/L). At the same time, the lowest water Li content was associated with Morocco (1.20 μg/L), Spain (0.46 μg/L), and India (0.13 μg/L). THQ due to Li in water resources in consumers of Iraq, Mexico, South Africa, Afghanistan, Bolivia, Portugal, Malawi, South Korea, Nepal, South Korea, Argentina, and the USA was higher than 1 value. Therefore, continuous monitoring of Li concentration in water sources and reducing Li concentration, especially in groundwater water, using new water treatment processes in these countries are recommended.

Florida's environments are suitable reservoirs for many disease-causing agents. Pathogens and toxins in Florida waterways have the potential to infect mosquito vectors, animals, and human hosts. Through a scoping review of the scientific literature published between 1999 and 2022, we examined the presence of water-related pathogens, toxins, and toxin-producers in the Florida environment and the potential risk factors for human exposure. Nineteen databases were searched using keywords relating to the waterborne, water-based toxins, and water-related vector-borne diseases which are reportable to the Florida Department of Health. Of the 10,439 results, 84 titles were included in the final qualitative analysis. The resulting titles included environmental samples of water, mosquitoes, algae, sand, soil/sediment, air, food, biofilm, and other media. Many of the waterborne, water-related vector-borne, and water-based toxins and toxin-producers of public health and veterinary importance from our search were found to be present in Florida environments. Interactions with Florida waterways can expose humans and animals to disease and toxins due to nearby human and/or animal activity, proximal animal or human waste, failing or inadequate water and/or sanitation, weather patterns, environmental events, and seasonality, contaminated food items, preference of agent for environmental media, high-risk populations, urban development and population movement, and unregulated and unsafe environmental activities. A One Health approach will be imperative to maintaining healthy waterways and shared environments throughout the state to protect the health of humans, animals, and our ecosystems.

The 'alarm clock' for human beings in the era of climate medicine has rung. Original diseases have appeared, that could not be explained and attributed to common causes, which are suggested to be linked to global warming and environmental factors. Such an indolent disease is the chronic kidney disease of unknown cause (CKDu), introduced also as Mesoamerican or Uddanam nephropathy. Scientists equate the climate impact on kidneys with the canary in the coal mine; coal miners used to carry caged canaries with them, so that if poisonous gases, such as methane or carbon monoxide leaked into the mine-shaft, the gases would kill the canary before killing the miners; similarly, kidneys are injured before devastating and lethal complications occur in humans. In some regions of Central America, the deaths due to chronic kidney disease increased by 177% with a death toll being as high as over 20,000. It was first documented in animals that periodic heat and dehydration have a major role in causing chronic kidney disease. Based on that observation, it is advocated that young male agricultural workers in Central America and South Asia, develop renal disease by getting exposed to extreme heat repeatedly. The clinico-pathological characteristics of this type of kidney injury, do not belong to an existing classification, even though a form of tubulo-interstitial renal disease has been proposed. In this review, we will discuss about CKDu, its epidemiology and pathophysiological mechanisms, clinical presentation and diagnostic biomarkers and examine potential therapeutic options.

Carbon nanomaterials (CNMs) are ubiquitous in our daily lives because of the outstanding physicochemical properties. CNMs play curial parts in industrial and medical fields, however, the risks of CNMs exposure to human health are still not fully understood. In view of, it is becoming extremely difficult to ignore the existence of the toxicity of CNMs. With the increasing exploitation of CNMs, it's necessary to evaluate the potential impact of these materials on human health. In recent years, more and more researches have shown that CNMs are contributed to the cancer formation and metastasis after long-term exposure through epithelial-mesenchymal transition (EMT) and cancer stem cells (CSCs) which is associated with cancer progression and invasion. This review discusses CNMs properties and applications in industrial and medical fields, adverse effects on human health, especially the induction of tumor initiation and metastasis through EMT and CSCs procedure.