Pub Date : 2023-05-17DOI: 10.15446/revfacmed.v71n4.104651
Yeison Guerrero, Cristian Jovan Rojas Romero
Varios estudios han mostrado que, en el escenario escolar, la fonoaudiología tiene un impacto significativo en la detección, promoción y el abordaje de los procesos inherentes a la comunicación humana como base para el aprendizaje, la participación y la inclusión. A pesar de esto, las disposiciones normativas recientes en Colombia no definen claramente el quehacer de este profesional en este escenario. Teniendo en cuenta lo anterior, el objetivo de este artículo es presentar un análisis crítico sobre del fonoaudiólogo en el contexto de la educación inclusiva en Colombia. En la primera parte del presente artículo se analizan los problemas en la denominación de la fonoaudiología y la pertinencia de sus funciones. Luego, se aborda el rol de este profesional en el contexto educativo. En la última parte se proponen algunas acciones para reivindicar el rol de los fonoaudiólogos en la inclusión y la equidad en la educación en términos de la eliminación de barreras del entorno y el fortalecimiento de capacidades de acuerdo con las particularidades de los estudiantes.
{"title":"Oportunidades y desafíos de la fonoaudiología para avanzar hacia una educación inclusiva en Colombia","authors":"Yeison Guerrero, Cristian Jovan Rojas Romero","doi":"10.15446/revfacmed.v71n4.104651","DOIUrl":"https://doi.org/10.15446/revfacmed.v71n4.104651","url":null,"abstract":"Varios estudios han mostrado que, en el escenario escolar, la fonoaudiología tiene un impacto significativo en la detección, promoción y el abordaje de los procesos inherentes a la comunicación humana como base para el aprendizaje, la participación y la inclusión. A pesar de esto, las disposiciones normativas recientes en Colombia no definen claramente el quehacer de este profesional en este escenario. Teniendo en cuenta lo anterior, el objetivo de este artículo es presentar un análisis crítico sobre del fonoaudiólogo en el contexto de la educación inclusiva en Colombia. En la primera parte del presente artículo se analizan los problemas en la denominación de la fonoaudiología y la pertinencia de sus funciones. Luego, se aborda el rol de este profesional en el contexto educativo. En la última parte se proponen algunas acciones para reivindicar el rol de los fonoaudiólogos en la inclusión y la equidad en la educación en términos de la eliminación de barreras del entorno y el fortalecimiento de capacidades de acuerdo con las particularidades de los estudiantes.","PeriodicalId":21295,"journal":{"name":"Revista de la Facultad de Medicina","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135960071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-10DOI: 10.22201/fm.24484865e.2023.66.3.05
Ángela Sánchez García, María Denise Ávila Perfino
A 63-year-old male patient admitted to ER due to dysuria, fever, suprapubic pain, and urinary retention since 3 days ago. Laboratory studies evidence of leukocytosis and neutrophilia. Renal and hepatic function preserved. Medical history reveals repeated prostatitis and diabetes type 2.
{"title":"Haga su diagnóstico","authors":"Ángela Sánchez García, María Denise Ávila Perfino","doi":"10.22201/fm.24484865e.2023.66.3.05","DOIUrl":"https://doi.org/10.22201/fm.24484865e.2023.66.3.05","url":null,"abstract":"A 63-year-old male patient admitted to ER due to dysuria, fever, suprapubic pain, and urinary retention since 3 days ago. Laboratory studies evidence of leukocytosis and neutrophilia. Renal and hepatic function preserved. Medical history reveals repeated prostatitis and diabetes type 2.","PeriodicalId":21295,"journal":{"name":"Revista de la Facultad de Medicina","volume":"220 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79623169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-10DOI: 10.22201/fm.24484865e.2023.66.3.04
Eddie Xhamanchi Sánchez Amaro, Héctor Alcántar Villanueva, Alfonso Martínez Ortíz, Edgar Paulo Valdivieso
The joint and massive presence of gallstones from the bile duct, both intra and extra hepatic, is a rare entity within the western population. Two cases are presented below, which debuted with a clinical picture of pain in the right hypo¬chondrium and with a clinical picture of pain in the right hypochondrium and with clinical and laboratory data of bile duct obstruction, and that by means of a resonance cholan¬giography study, multiple endoluminal stones of the bile duct are evidenced. Overall, it also shows the treatment of one of the cases by ERCP with successful evacuation of the gallstones. Keywords: Lithiasis; bile duct; massive; resonance cholangio; endoscopic retrograde cholangiography (ERCP).
{"title":"Litiasis masiva de la vía biliar intra y extra hepática. Reporte de 2 casos","authors":"Eddie Xhamanchi Sánchez Amaro, Héctor Alcántar Villanueva, Alfonso Martínez Ortíz, Edgar Paulo Valdivieso","doi":"10.22201/fm.24484865e.2023.66.3.04","DOIUrl":"https://doi.org/10.22201/fm.24484865e.2023.66.3.04","url":null,"abstract":"The joint and massive presence of gallstones from the bile duct, both intra and extra hepatic, is a rare entity within the western population. Two cases are presented below, which debuted with a clinical picture of pain in the right hypo¬chondrium and with a clinical picture of pain in the right hypochondrium and with clinical and laboratory data of bile duct obstruction, and that by means of a resonance cholan¬giography study, multiple endoluminal stones of the bile duct are evidenced. Overall, it also shows the treatment of one of the cases by ERCP with successful evacuation of the gallstones. Keywords: Lithiasis; bile duct; massive; resonance cholangio; endoscopic retrograde cholangiography (ERCP).","PeriodicalId":21295,"journal":{"name":"Revista de la Facultad de Medicina","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84718969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-10DOI: 10.22201/fm.24484865e.2023.66.3.03
Emmanuel A. Chávez-Martínez, Daniel Martínez Cabrera, Claudia S. Padilla-Estrada, H. E. Hernández-Martínez, M. G. Ochoa Madrigal
Background: Systemic lupus erythematosus is a chronic mul tisystemic autoimmune disease with diverse clinical mani festations. Women are the most vulnerable population and have the greatest neurological involvement with a higher risk of seizures. Neuropsychiatric manifestations occur in early stages of the disease and diagnosis since they can occur together with systemic manifestations or not. The frequency of neuropsychiatric manifestations in systemic lupus erythe matosus has been described from 14 to 75%; being cognitive alterations one of the major symptoms to highlight. Which, in the same way can be accompanied by affective disorders such as depression and anxiety. Since psychosis, secondary to SLE, stands out for its low prevalence (10%), laboratory studies usually guide us towards a definitive diagnosis, being ribosomal P antibodies the ones that have been more spe cifically related to lupus psychosis. MRI is the test of choice and brain lesions are dominated by punctate white matter hyperintensities. In the following case report, we present a 20-year-old pa tient who had a history of diagnosed hepatic steatosis, MODY type diabetes and resection of the right ovary for mature teratoma of 9 years of evolution; but with no psychiatric his tory of importance at the time of her evaluation. However, she acutely presented a psychotic outbreak characterized by delusions of grandiosity and reference; as well as behavioral, cognitive, and affective alterations. For which she had to go to a 3rd level hospital during the period of health contin gency in 2020. After a history of SARS-CoV-2 infection three months before her neuropsychiatric pathology, neurological symptoms secondary to COVID-19 infection were suspected, as well as isolated psychiatric pathology. Therefore, a study approach of the first psychotic outbreak was performed, diagnosing systemic lupus erythematosus with neuropsy chiatric manifestations. Treatment was based on a bolus of methylprednisolone and antipsychotics; later modified by therapy with oral corticosteroids and depot antipsychotic. Conclusion: Systemic lupus erythematosus with neuropsy chiatric manifestations is an infrequent presentation of the disease, because of the wide variation in its appearance, pa tients with psychiatric symptoms in a general hospital setting should be considered for extensive approaches. In the same way, having this knowledge of this case may broaden our knowledge about the complications of this rheumatologic pathology. And one of its most serious complications such as lupus psychosis to be able to make a better approach to the first psychotic outbreak in general hospitals, where the assessment of a specialist can be more complicated. Keywords: Psychotic break; hallucinations; anti-NMDA antibod ies; neurolupus (NPLSE); COVID-19; case report
{"title":"Neurolupus como manifestación de primer brote psicótico: reporte de caso.","authors":"Emmanuel A. Chávez-Martínez, Daniel Martínez Cabrera, Claudia S. Padilla-Estrada, H. E. Hernández-Martínez, M. G. Ochoa Madrigal","doi":"10.22201/fm.24484865e.2023.66.3.03","DOIUrl":"https://doi.org/10.22201/fm.24484865e.2023.66.3.03","url":null,"abstract":"Background: Systemic lupus erythematosus is a chronic mul tisystemic autoimmune disease with diverse clinical mani festations. Women are the most vulnerable population and have the greatest neurological involvement with a higher risk of seizures. Neuropsychiatric manifestations occur in early stages of the disease and diagnosis since they can occur together with systemic manifestations or not. The frequency of neuropsychiatric manifestations in systemic lupus erythe matosus has been described from 14 to 75%; being cognitive alterations one of the major symptoms to highlight. Which, in the same way can be accompanied by affective disorders such as depression and anxiety. Since psychosis, secondary to SLE, stands out for its low prevalence (10%), laboratory studies usually guide us towards a definitive diagnosis, being ribosomal P antibodies the ones that have been more spe cifically related to lupus psychosis. MRI is the test of choice and brain lesions are dominated by punctate white matter hyperintensities. In the following case report, we present a 20-year-old pa tient who had a history of diagnosed hepatic steatosis, MODY type diabetes and resection of the right ovary for mature teratoma of 9 years of evolution; but with no psychiatric his tory of importance at the time of her evaluation. However, she acutely presented a psychotic outbreak characterized by delusions of grandiosity and reference; as well as behavioral, cognitive, and affective alterations. For which she had to go to a 3rd level hospital during the period of health contin gency in 2020. After a history of SARS-CoV-2 infection three months before her neuropsychiatric pathology, neurological symptoms secondary to COVID-19 infection were suspected, as well as isolated psychiatric pathology. Therefore, a study approach of the first psychotic outbreak was performed, diagnosing systemic lupus erythematosus with neuropsy chiatric manifestations. Treatment was based on a bolus of methylprednisolone and antipsychotics; later modified by therapy with oral corticosteroids and depot antipsychotic. Conclusion: Systemic lupus erythematosus with neuropsy chiatric manifestations is an infrequent presentation of the disease, because of the wide variation in its appearance, pa tients with psychiatric symptoms in a general hospital setting should be considered for extensive approaches. In the same way, having this knowledge of this case may broaden our knowledge about the complications of this rheumatologic pathology. And one of its most serious complications such as lupus psychosis to be able to make a better approach to the first psychotic outbreak in general hospitals, where the assessment of a specialist can be more complicated. Keywords: Psychotic break; hallucinations; anti-NMDA antibod ies; neurolupus (NPLSE); COVID-19; case report","PeriodicalId":21295,"journal":{"name":"Revista de la Facultad de Medicina","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83321869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-10DOI: 10.22201/fm.24484865e.2023.66.3.02
Andrea Herrera Solís, Aline Ostos Valverde, Alejandra E. Ruiz Contreras, Mónica Méndez Díaz, Jacqueline Cortés Morelos, Silvia del Carmen Chavira Estefan, Oscar E. Prospéro García
Opium and its derivatives, and recently the opioids have ac companied the humankind since the ancient civilizations to the present day. Its analgesic, hypnotic and pleasant effects did not go unnoticed by ancient people, which considered most of these effects of medical utility and noticed that they had remarkable mood benefits. Currently, there are no other kind of drugs that can palliate intense pain as efficiently as these powerful analgesics. However, the medical and rec reational use of opiates and opioids may carry health risks such as tolerance, hyperalgesia, and addiction. Nowadays, in addition to being indisputably the most powerful medical treatment to alleviate the suffering caused by pain, it has also become a public health problem due to the high number of people with opioid use disorder that have facilitated deaths caused by opioids overdose. In this review we will discuss the medical benefits of opiates and opioids, as much as the unwanted effects they produce. Keywords: Opioids; opiates; medical utility; health risks; addiction; abuse.
{"title":"Amapola, lindísima amapola: de los opiáceos y los opioides, utilidad y riesgos.","authors":"Andrea Herrera Solís, Aline Ostos Valverde, Alejandra E. Ruiz Contreras, Mónica Méndez Díaz, Jacqueline Cortés Morelos, Silvia del Carmen Chavira Estefan, Oscar E. Prospéro García","doi":"10.22201/fm.24484865e.2023.66.3.02","DOIUrl":"https://doi.org/10.22201/fm.24484865e.2023.66.3.02","url":null,"abstract":"Opium and its derivatives, and recently the opioids have ac companied the humankind since the ancient civilizations to the present day. Its analgesic, hypnotic and pleasant effects did not go unnoticed by ancient people, which considered most of these effects of medical utility and noticed that they had remarkable mood benefits. Currently, there are no other kind of drugs that can palliate intense pain as efficiently as these powerful analgesics. However, the medical and rec reational use of opiates and opioids may carry health risks such as tolerance, hyperalgesia, and addiction. Nowadays, in addition to being indisputably the most powerful medical treatment to alleviate the suffering caused by pain, it has also become a public health problem due to the high number of people with opioid use disorder that have facilitated deaths caused by opioids overdose. In this review we will discuss the medical benefits of opiates and opioids, as much as the unwanted effects they produce. Keywords: Opioids; opiates; medical utility; health risks; addiction; abuse.","PeriodicalId":21295,"journal":{"name":"Revista de la Facultad de Medicina","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83161236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-10DOI: 10.22201/fm.24484865e.2023.66.3.01
Teresa I. Fortoul van der Goes
As in Baudelaire's essays, artificial paradises, well-used drugs such as opium can stimulate a sense of well-being and absence of pain. Although with the risks of dependence, intoxication and even death, the need for powerful painkillers has led to the production of synthetic drugs of easy manufacture and low cost such as fentanyl that in the wrong hands, for illicit purposes and without specialized medical supervision, are a deadly weapon. Is it worth taking the risks looking for paradise lost?
{"title":"¿Por el paraíso perdido?","authors":"Teresa I. Fortoul van der Goes","doi":"10.22201/fm.24484865e.2023.66.3.01","DOIUrl":"https://doi.org/10.22201/fm.24484865e.2023.66.3.01","url":null,"abstract":"As in Baudelaire's essays, artificial paradises, well-used drugs such as opium can stimulate a sense of well-being and absence of pain. Although with the risks of dependence, intoxication and even death, the need for powerful painkillers has led to the production of synthetic drugs of easy manufacture and low cost such as fentanyl that in the wrong hands, for illicit purposes and without specialized medical supervision, are a deadly weapon. Is it worth taking the risks looking for paradise lost?","PeriodicalId":21295,"journal":{"name":"Revista de la Facultad de Medicina","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88656069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-05-10DOI: 10.22201/fm.24484865e.2023.66.3.07
T. Fortoul
They had physical deformations and were called phenomena or monsters and were often exhibited as shows in tents or circuses. The life, work and struggles of this artist with a disability, invites us to reflect and formulate commitments to understand disabilities: physical, visual and auditory, intellectual and visceral that present 15% of the world population and generate empathy to be more inclusive with them.
{"title":"Incapacidad no es lo mismo que discapacidad","authors":"T. Fortoul","doi":"10.22201/fm.24484865e.2023.66.3.07","DOIUrl":"https://doi.org/10.22201/fm.24484865e.2023.66.3.07","url":null,"abstract":"They had physical deformations and were called phenomena or monsters and were often exhibited as shows in tents or circuses. The life, work and struggles of this artist with a disability, invites us to reflect and formulate commitments to understand disabilities: physical, visual and auditory, intellectual and visceral that present 15% of the world population and generate empathy to be more inclusive with them.","PeriodicalId":21295,"journal":{"name":"Revista de la Facultad de Medicina","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74967269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: the formation of the medical professional identity is achieved in stages during which the characteristics, values and norms of the medical profession are internalized, which results in the individual thinking, acting and feeling like a doctor. Tutors in medicine should clarify and encourage the principles within study programs and learning environments in order to support the formation of the professional identity of their students. Objective: the purpose of this paper is to reveal the participation of medical tutoring as one of the most influential factors that contribute to the development of the professional identity of medical students, as well as to give some guidelines so that the training of tutors. It contemplates tools that allow them to contribute to the positive and valued construction of the professional identity of the students. Keywords: Professional identity; student; tutoring; teaching; medicine
{"title":"La tutoría como un factor influyente en la identidad profesional del alumno de pregrado de medicina","authors":"Tania Vives Varela, Daniela Hazel Salazar Hernández","doi":"10.22201/fm.24484865e.2023.66.3.06","DOIUrl":"https://doi.org/10.22201/fm.24484865e.2023.66.3.06","url":null,"abstract":"Introduction: the formation of the medical professional identity is achieved in stages during which the characteristics, values and norms of the medical profession are internalized, which results in the individual thinking, acting and feeling like a doctor. Tutors in medicine should clarify and encourage the principles within study programs and learning environments in order to support the formation of the professional identity of their students. Objective: the purpose of this paper is to reveal the participation of medical tutoring as one of the most influential factors that contribute to the development of the professional identity of medical students, as well as to give some guidelines so that the training of tutors. It contemplates tools that allow them to contribute to the positive and valued construction of the professional identity of the students. Keywords: Professional identity; student; tutoring; teaching; medicine","PeriodicalId":21295,"journal":{"name":"Revista de la Facultad de Medicina","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135671163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-11DOI: 10.22201/fm.24484865e.2023.66.2.08
Hasta sus últimos días, William Turner vivió una vida solitaria. Aunque no fue un artista de las relaciones sociales, el pintor británico, le dió un nuevo sentido a la historia del arte. Extraordinariamente popular por su audacia y talento fue un experimentador que llevó al óleo técnicas propias de la acuarela, y se acercó al impresionismo e incluso al arte abstracto. Reconcilió al hombre con la naturaleza pues en sus pinturas, por primera vez, los paisajes tenían un papel protagónico.
{"title":"El placer estético: William Turner","authors":"","doi":"10.22201/fm.24484865e.2023.66.2.08","DOIUrl":"https://doi.org/10.22201/fm.24484865e.2023.66.2.08","url":null,"abstract":"Hasta sus últimos días, William Turner vivió una vida solitaria. Aunque no fue un artista de las relaciones sociales, el pintor británico, le dió un nuevo sentido a la historia del arte. Extraordinariamente popular por su audacia y talento fue un experimentador que llevó al óleo técnicas propias de la acuarela, y se acercó al impresionismo e incluso al arte abstracto. Reconcilió al hombre con la naturaleza pues en sus pinturas, por primera vez, los paisajes tenían un papel protagónico.","PeriodicalId":21295,"journal":{"name":"Revista de la Facultad de Medicina","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86057474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-10DOI: 10.22201/fm.24484865e.2023.66.2.02
G. Pavón-Romero, Katia Vanessa Gutiérrez-Quiroz, Fernando Ramírez-Jiménez, Rodrigo Rosas-Fernández, María Itzel Parra-Vargas, L. M. Terán
DRESS (drug reaction syndrome with eosinophilia and sys¬temic symptoms) is a rare drug-induced multisystemic hy-persensitivity response that can induce a severe cutaneous adverse reaction that is difficult to diagnose and treat. It fre-quently manifests as an extensive skin rash, systemic symp¬toms, lymphadenopathy, visceral organ involvement, and hematological alterations, mainly leukocytosis, eosinophilia, and sometimes atypical lymphocytosis that manifest 2 to 8 weeks after continuous administration of the responsible drug. The most prevalent drugs related with this syndrome are phenytoin, carbamazepine, allopurinol, and abacavir. Some specific human leukocyte antigen (HLA) alleles have been identified that are associated with hypersensitivity to these drugs. The pathophysiology of DRESS syndrome is not yet fully understood; the main hypothesis is a T-cell me¬diated hypersensitivity response when interacting with the major histocompatibility complex receptor in individuals with genetic susceptibility factors. The criteria of the European Registry of Severe Cutaneous Adverse Reactions to Drugs (RegiSCAR) are the most commonly used for the diagnosis of DRESS syndrome. Drug-induced hypersensitivity syndrome (DiHS), Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and acute generalized exanthematous pustulosis (AGEP) should be considered for any rash that appears following the administration of any drug. Therapy of this condition includes the elimination of the causative agent as soon as possible, as well as systemic corticosteroids which remain the mainstay of treatment of DRESS with in-ternal organ involvement. Steroid-sparing agents such as cyclosporine, intravenous immunoglobulins (IVIGs), and other immunosuppressive agents have been used successfully to contribute to treatment. Keywords: DRESS; drug hypersensitivity syndrome; adverse drug reactions; hypersensitivity reaction; eosinophilia.
{"title":"DRESS, una reacción alérgica no mediada por IgE","authors":"G. Pavón-Romero, Katia Vanessa Gutiérrez-Quiroz, Fernando Ramírez-Jiménez, Rodrigo Rosas-Fernández, María Itzel Parra-Vargas, L. M. Terán","doi":"10.22201/fm.24484865e.2023.66.2.02","DOIUrl":"https://doi.org/10.22201/fm.24484865e.2023.66.2.02","url":null,"abstract":"DRESS (drug reaction syndrome with eosinophilia and sys¬temic symptoms) is a rare drug-induced multisystemic hy-persensitivity response that can induce a severe cutaneous adverse reaction that is difficult to diagnose and treat. It fre-quently manifests as an extensive skin rash, systemic symp¬toms, lymphadenopathy, visceral organ involvement, and hematological alterations, mainly leukocytosis, eosinophilia, and sometimes atypical lymphocytosis that manifest 2 to 8 weeks after continuous administration of the responsible drug. The most prevalent drugs related with this syndrome are phenytoin, carbamazepine, allopurinol, and abacavir. Some specific human leukocyte antigen (HLA) alleles have been identified that are associated with hypersensitivity to these drugs. The pathophysiology of DRESS syndrome is not yet fully understood; the main hypothesis is a T-cell me¬diated hypersensitivity response when interacting with the major histocompatibility complex receptor in individuals with genetic susceptibility factors. The criteria of the European Registry of Severe Cutaneous Adverse Reactions to Drugs (RegiSCAR) are the most commonly used for the diagnosis of DRESS syndrome. Drug-induced hypersensitivity syndrome (DiHS), Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and acute generalized exanthematous pustulosis (AGEP) should be considered for any rash that appears following the administration of any drug. Therapy of this condition includes the elimination of the causative agent as soon as possible, as well as systemic corticosteroids which remain the mainstay of treatment of DRESS with in-ternal organ involvement. Steroid-sparing agents such as cyclosporine, intravenous immunoglobulins (IVIGs), and other immunosuppressive agents have been used successfully to contribute to treatment.\u0000Keywords: DRESS; drug hypersensitivity syndrome; adverse drug reactions; hypersensitivity reaction; eosinophilia.","PeriodicalId":21295,"journal":{"name":"Revista de la Facultad de Medicina","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88509585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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