The recent discovery of nonvisual photoreceptors in various organs has raised expectations for uncovering their roles and underlying mechanisms. In this work, we identified a previously unrecognized hormone-releasing mechanism in the pituitary of the Japanese rice fish (medaka) induced by light. Ca 2+ imaging analysis revealed that melanotrophs, a type of pituitary endocrine cell that secretes melanocyte-stimulating hormone, robustly increase the concentration of intracellular Ca 2+ during short-wavelength light exposure. Moreover, we identified Opn5m as the key molecule that drives this response. Knocking out opn5m attenuated melanogenesis by reducing tyrosinase expression in the skin. Our findings suggest a mechanism in which direct reception of short-wavelength light by pituitary melanotrophs triggers a pathway that might contribute to protection from ultraviolet radiation in medaka.
{"title":"Direct photoreception by pituitary endocrine cells regulates hormone release and pigmentation","authors":"Ayaka Fukuda, Keita Sato, Chika Fujimori, Takahiro Yamashita, Atsuko Takeuchi, Hideyo Ohuchi, Chie Umatani, Shinji Kanda","doi":"10.1126/science.adj9687","DOIUrl":"https://doi.org/10.1126/science.adj9687","url":null,"abstract":"The recent discovery of nonvisual photoreceptors in various organs has raised expectations for uncovering their roles and underlying mechanisms. In this work, we identified a previously unrecognized hormone-releasing mechanism in the pituitary of the Japanese rice fish (medaka) induced by light. Ca <jats:sup>2+</jats:sup> imaging analysis revealed that melanotrophs, a type of pituitary endocrine cell that secretes melanocyte-stimulating hormone, robustly increase the concentration of intracellular Ca <jats:sup>2+</jats:sup> during short-wavelength light exposure. Moreover, we identified Opn5m as the key molecule that drives this response. Knocking out <jats:italic>opn5m</jats:italic> attenuated melanogenesis by reducing <jats:italic>tyrosinase</jats:italic> expression in the skin. Our findings suggest a mechanism in which direct reception of short-wavelength light by pituitary melanotrophs triggers a pathway that might contribute to protection from ultraviolet radiation in medaka.","PeriodicalId":21678,"journal":{"name":"Science","volume":"1 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142917187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
As the calendar turns to 2025, the unflagging pace of advancement in science and technology promises to break new ground in areas as profound as humanity’s relationship with artificial intelligence (AI), gene editing in medicine and agriculture, climate change mitigation, and more. Meanwhile, as research across all fields becomes more complex, the challenge of maintaining research integrity and the reliability of scientific findings becomes more important than ever for informing public policies and bolstering trust in science. All organizations in the scientific enterprise have a responsibility to ensure that sound practices and ethical standards are at the heart of their operations and missions. This includes scientific journals.
{"title":"Steady going in 2025","authors":"H. Holden Thorp, Valda Vinson, Lauren Kmec","doi":"10.1126/science.adv4633","DOIUrl":"https://doi.org/10.1126/science.adv4633","url":null,"abstract":"As the calendar turns to 2025, the unflagging pace of advancement in science and technology promises to break new ground in areas as profound as humanity’s relationship with artificial intelligence (AI), gene editing in medicine and agriculture, climate change mitigation, and more. Meanwhile, as research across all fields becomes more complex, the challenge of maintaining research integrity and the reliability of scientific findings becomes more important than ever for informing public policies and bolstering trust in science. All organizations in the scientific enterprise have a responsibility to ensure that sound practices and ethical standards are at the heart of their operations and missions. This includes scientific journals.","PeriodicalId":21678,"journal":{"name":"Science","volume":"68 10 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142917188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hogyun Seo, Hwaseok Hong, Jiyoung Park, Seul Hoo Lee, Dongwoo Ki, Aejin Ryu, Hye-Young Sagong, Kyung-Jin Kim
Enzymes capable of breaking down polymers have been identified from natural sources and developed for industrial use in plastic recycling. However, there are many potential starting points for enzyme optimization that remain unexplored. We generated a landscape of 170 lineages of 1894 polyethylene terephthalate depolymerase (PETase) candidates and performed profiling using sampling approaches with features associated with PET-degrading capabilities. We identified three promising yet unexplored PETase lineages and two potent PETases, Mipa-P and Kubu-P. An engineered variant of Kubu-P outperformed benchmarks in terms of PET depolymerization in harsh environments, such as those with high substrate load and ethylene glycol as the solvent.
{"title":"Landscape profiling of PET depolymerases using a natural sequence cluster framework","authors":"Hogyun Seo, Hwaseok Hong, Jiyoung Park, Seul Hoo Lee, Dongwoo Ki, Aejin Ryu, Hye-Young Sagong, Kyung-Jin Kim","doi":"10.1126/science.adp5637","DOIUrl":"https://doi.org/10.1126/science.adp5637","url":null,"abstract":"Enzymes capable of breaking down polymers have been identified from natural sources and developed for industrial use in plastic recycling. However, there are many potential starting points for enzyme optimization that remain unexplored. We generated a landscape of 170 lineages of 1894 polyethylene terephthalate depolymerase (PETase) candidates and performed profiling using sampling approaches with features associated with PET-degrading capabilities. We identified three promising yet unexplored PETase lineages and two potent PETases, Mipa-P and Kubu-P. An engineered variant of Kubu-P outperformed benchmarks in terms of PET depolymerization in harsh environments, such as those with high substrate load and ethylene glycol as the solvent.","PeriodicalId":21678,"journal":{"name":"Science","volume":"34 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142917186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Weiwei Wang, Xianli Wang, Mike D. Flannigan, Luc Guindon, Tom Swystun, Dante Castellanos-Acuna, Wanli Wu, Guangyu Wang
Canada has experienced more-intense and longer fire seasons with more-frequent uncontrollable wildfires over the past decades. However, the effect of these changes remains unknown. This study identifies driving forces of burn severity and estimates its spatiotemporal variations in Canadian forests. Our results show that fuel aridity was the most influential driver of burn severity, summer months were more prone to severe burning, and the northern areas were most influenced by the changing climate. About 6% (0.54 to 14.64%) of the modeled areas show significant increases in the number of days conducive to high-severity burning during 1981 to 2020, most of which were found during 2001 to 2020 and in the spring and autumn. The extraordinary 2023 fire season demonstrated similar spatial patterns but more-widespread escalations in burn severity.
{"title":"Canadian forests are more conducive to high-severity fires in recent decades","authors":"Weiwei Wang, Xianli Wang, Mike D. Flannigan, Luc Guindon, Tom Swystun, Dante Castellanos-Acuna, Wanli Wu, Guangyu Wang","doi":"10.1126/science.ado1006","DOIUrl":"https://doi.org/10.1126/science.ado1006","url":null,"abstract":"Canada has experienced more-intense and longer fire seasons with more-frequent uncontrollable wildfires over the past decades. However, the effect of these changes remains unknown. This study identifies driving forces of burn severity and estimates its spatiotemporal variations in Canadian forests. Our results show that fuel aridity was the most influential driver of burn severity, summer months were more prone to severe burning, and the northern areas were most influenced by the changing climate. About 6% (0.54 to 14.64%) of the modeled areas show significant increases in the number of days conducive to high-severity burning during 1981 to 2020, most of which were found during 2001 to 2020 and in the spring and autumn. The extraordinary 2023 fire season demonstrated similar spatial patterns but more-widespread escalations in burn severity.","PeriodicalId":21678,"journal":{"name":"Science","volume":"4 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142917191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Asir Intisar Khan, Akash Ramdas, Emily Lindgren, Hyun-Mi Kim, Byoungjun Won, Xiangjin Wu, Krishna Saraswat, Ching-Tzu Chen, Yuri Suzuki, Felipe H. da Jornada, Il-Kwon Oh, Eric Pop
The electrical resistivity of conventional metals such as copper is known to increase in thin films as a result of electron-surface scattering, thus limiting the performance of metals in nanoscale electronics. Here, we find an unusual reduction of resistivity with decreasing film thickness in niobium phosphide (NbP) semimetal deposited at relatively low temperatures of 400°C. In films thinner than 5 nanometers, the room temperature resistivity (~34 microhm centimeters for 1.5-nanometer-thick NbP) is up to six times lower than the resistivity of our bulk NbP films, and lower than conventional metals at similar thickness (typically about 100 microhm centimeters). The NbP films are not crystalline but display local nanocrystalline, short-range order within an amorphous matrix. Our analysis suggests that the lower effective resistivity is caused by conduction through surface channels, together with high surface carrier density and sufficiently good mobility as the film thickness is reduced. These results and the fundamental insights obtained here could enable ultrathin, low-resistivity wires for nanoelectronics beyond the limitations of conventional metals.
{"title":"Surface conduction and reduced electrical resistivity in ultrathin noncrystalline NbP semimetal","authors":"Asir Intisar Khan, Akash Ramdas, Emily Lindgren, Hyun-Mi Kim, Byoungjun Won, Xiangjin Wu, Krishna Saraswat, Ching-Tzu Chen, Yuri Suzuki, Felipe H. da Jornada, Il-Kwon Oh, Eric Pop","doi":"10.1126/science.adq7096","DOIUrl":"https://doi.org/10.1126/science.adq7096","url":null,"abstract":"The electrical resistivity of conventional metals such as copper is known to increase in thin films as a result of electron-surface scattering, thus limiting the performance of metals in nanoscale electronics. Here, we find an unusual reduction of resistivity with decreasing film thickness in niobium phosphide (NbP) semimetal deposited at relatively low temperatures of 400°C. In films thinner than 5 nanometers, the room temperature resistivity (~34 microhm centimeters for 1.5-nanometer-thick NbP) is up to six times lower than the resistivity of our bulk NbP films, and lower than conventional metals at similar thickness (typically about 100 microhm centimeters). The NbP films are not crystalline but display local nanocrystalline, short-range order within an amorphous matrix. Our analysis suggests that the lower effective resistivity is caused by conduction through surface channels, together with high surface carrier density and sufficiently good mobility as the film thickness is reduced. These results and the fundamental insights obtained here could enable ultrathin, low-resistivity wires for nanoelectronics beyond the limitations of conventional metals.","PeriodicalId":21678,"journal":{"name":"Science","volume":"24 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142917317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Edward Hurme, Ivan Lenzi, Martin Wikelski, Timm A. Wild, Dina K. N. Dechmann
Long-distance migration, common in passerine birds, is rare and poorly studied in bats. Piloting a 1.2-gram IoT (Internet of Things) tag with onboard processing, we tracked the daily location, temperature, and activity of female common noctules ( Nyctalus noctula ) during spring migration across central Europe up to 1116 kilometers. Over 3 years, 71 bats migrated tens to hundreds of kilometers per night, predominantly with incoming warm fronts, which provided them with wind support. Bats also showed unexpected flexibility in their ability to migrate across a wide range of conditions if needed. However, females leaving toward the end of the season showed higher total activity per distance traveled, a possible cost for their flexible migration timing.
{"title":"Bats surf storm fronts during spring migration","authors":"Edward Hurme, Ivan Lenzi, Martin Wikelski, Timm A. Wild, Dina K. N. Dechmann","doi":"10.1126/science.ade7441","DOIUrl":"https://doi.org/10.1126/science.ade7441","url":null,"abstract":"Long-distance migration, common in passerine birds, is rare and poorly studied in bats. Piloting a 1.2-gram IoT (Internet of Things) tag with onboard processing, we tracked the daily location, temperature, and activity of female common noctules ( <jats:italic>Nyctalus noctula</jats:italic> ) during spring migration across central Europe up to 1116 kilometers. Over 3 years, 71 bats migrated tens to hundreds of kilometers per night, predominantly with incoming warm fronts, which provided them with wind support. Bats also showed unexpected flexibility in their ability to migrate across a wide range of conditions if needed. However, females leaving toward the end of the season showed higher total activity per distance traveled, a possible cost for their flexible migration timing.","PeriodicalId":21678,"journal":{"name":"Science","volume":"40 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142917175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jiahao Zhang, Xianbiao Fu, Soonho Kwon, Kaifeng Chen, Xiaozhi Liu, Jin Yang, Haoran Sun, Yanchang Wang, Tomoki Uchiyama, Yoshiharu Uchimoto, Shaofeng Li, Yan Li, Xiaolong Fan, Gong Chen, Fanjie Xia, Jinsong Wu, Yanbo Li, Qin Yue, Liang Qiao, Dong Su, Hua Zhou, William A. Goddard, Yijin Kang
The iridium oxide (IrO 2 ) catalyst for the oxygen evolution reaction used industrially (in proton exchange membrane water electrolyzers) is scarce and costly. Although ruthenium oxide (RuO 2 ) is a promising alternative, its poor stability has hindered practical application. We used well-defined extended surface models to identify that RuO 2 undergoes structure-dependent corrosion that causes Ru dissolution. Tantalum (Ta) doping effectively stabilized RuO 2 against such corrosion and enhanced the intrinsic activity of RuO 2 . In an industrial demonstration, Ta-RuO 2 electrocatalyst exhibited stability near that of IrO 2 and had a performance decay rate of ~14 microvolts per hour in a 2800-hour test. At current densities of 1 ampere per square centimeter, it had an overpotential 330 millivolts less than that of IrO 2 .
{"title":"Tantalum-stabilized ruthenium oxide electrocatalysts for industrial water electrolysis","authors":"Jiahao Zhang, Xianbiao Fu, Soonho Kwon, Kaifeng Chen, Xiaozhi Liu, Jin Yang, Haoran Sun, Yanchang Wang, Tomoki Uchiyama, Yoshiharu Uchimoto, Shaofeng Li, Yan Li, Xiaolong Fan, Gong Chen, Fanjie Xia, Jinsong Wu, Yanbo Li, Qin Yue, Liang Qiao, Dong Su, Hua Zhou, William A. Goddard, Yijin Kang","doi":"10.1126/science.ado9938","DOIUrl":"https://doi.org/10.1126/science.ado9938","url":null,"abstract":"The iridium oxide (IrO <jats:sub>2</jats:sub> ) catalyst for the oxygen evolution reaction used industrially (in proton exchange membrane water electrolyzers) is scarce and costly. Although ruthenium oxide (RuO <jats:sub>2</jats:sub> ) is a promising alternative, its poor stability has hindered practical application. We used well-defined extended surface models to identify that RuO <jats:sub>2</jats:sub> undergoes structure-dependent corrosion that causes Ru dissolution. Tantalum (Ta) doping effectively stabilized RuO <jats:sub>2</jats:sub> against such corrosion and enhanced the intrinsic activity of RuO <jats:sub>2</jats:sub> . In an industrial demonstration, Ta-RuO <jats:sub>2</jats:sub> electrocatalyst exhibited stability near that of IrO <jats:sub>2</jats:sub> and had a performance decay rate of ~14 microvolts per hour in a 2800-hour test. At current densities of 1 ampere per square centimeter, it had an overpotential 330 millivolts less than that of IrO <jats:sub>2</jats:sub> .","PeriodicalId":21678,"journal":{"name":"Science","volume":"7 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142917176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paige Leary, Celine Bellegarda, Cheryl Quainoo, Dena Goldblatt, Başak Rosti, David Schoppik
Vertebrates stabilize gaze using a neural circuit that transforms sensed instability into compensatory counterrotation of the eyes. Sensory feedback tunes this vestibulo-ocular reflex throughout life. We studied the functional development of vestibulo-ocular reflex circuit components in the larval zebrafish, with and without sensation. Blind fish stabilize gaze normally, and neural responses to body tilts mature before behavior. In contrast, synapses between motor neurons and the eye muscles mature with a time course similar to behavioral maturation. Larvae without vestibular sensory experience, but with mature neuromuscular junctions, had a strong vestibulo-ocular reflex. Development of the neuromuscular junction, and not sensory experience, therefore determines the rate of maturation of an ancient behavior.
{"title":"Sensation is dispensable for the maturation of the vestibulo-ocular reflex","authors":"Paige Leary, Celine Bellegarda, Cheryl Quainoo, Dena Goldblatt, Başak Rosti, David Schoppik","doi":"10.1126/science.adr9982","DOIUrl":"https://doi.org/10.1126/science.adr9982","url":null,"abstract":"Vertebrates stabilize gaze using a neural circuit that transforms sensed instability into compensatory counterrotation of the eyes. Sensory feedback tunes this vestibulo-ocular reflex throughout life. We studied the functional development of vestibulo-ocular reflex circuit components in the larval zebrafish, with and without sensation. Blind fish stabilize gaze normally, and neural responses to body tilts mature before behavior. In contrast, synapses between motor neurons and the eye muscles mature with a time course similar to behavioral maturation. Larvae without vestibular sensory experience, but with mature neuromuscular junctions, had a strong vestibulo-ocular reflex. Development of the neuromuscular junction, and not sensory experience, therefore determines the rate of maturation of an ancient behavior.","PeriodicalId":21678,"journal":{"name":"Science","volume":"26 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142917193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jeffrey S. Groh, Diane C. Vik, Matthew Davis, J. Grey Monroe, Kristian A. Stevens, Patrick J. Brown, Charles H. Langley, Graham Coop
Balanced mating type polymorphisms offer a distinct window into the forces shaping sexual reproduction strategies. Multiple hermaphroditic genera in Juglandaceae, including walnuts ( Juglans ) and hickories ( Carya ), show a 1:1 genetic dimorphism for male versus female flowering order (heterodichogamy). We map two distinct Mendelian inheritance mechanisms to ancient (>37 million years old) genus-wide structural DNA polymorphisms. The dominant haplotype for female-first flowering in Juglans contains tandem repeats of the 3′ untranslated region of a gene putatively involved in trehalose-6-phosphate metabolism and is associated with increased cis gene expression in developing male flowers, possibly mediated by small RNAs. The Carya locus contains ~20 syntenic genes and shows molecular signatures of sex chromosome–like evolution. Inheritance mechanisms for heterodichogamy are deeply conserved, yet may occasionally turn over, as in sex determination.
{"title":"Ancient structural variants control sex-specific flowering time morphs in walnuts and hickories","authors":"Jeffrey S. Groh, Diane C. Vik, Matthew Davis, J. Grey Monroe, Kristian A. Stevens, Patrick J. Brown, Charles H. Langley, Graham Coop","doi":"10.1126/science.ado5578","DOIUrl":"https://doi.org/10.1126/science.ado5578","url":null,"abstract":"Balanced mating type polymorphisms offer a distinct window into the forces shaping sexual reproduction strategies. Multiple hermaphroditic genera in Juglandaceae, including walnuts ( <jats:italic>Juglans</jats:italic> ) and hickories ( <jats:italic>Carya</jats:italic> ), show a 1:1 genetic dimorphism for male versus female flowering order (heterodichogamy). We map two distinct Mendelian inheritance mechanisms to ancient (>37 million years old) genus-wide structural DNA polymorphisms. The dominant haplotype for female-first flowering in <jats:italic>Juglans</jats:italic> contains tandem repeats of the 3′ untranslated region of a gene putatively involved in trehalose-6-phosphate metabolism and is associated with increased <jats:italic>cis</jats:italic> gene expression in developing male flowers, possibly mediated by small RNAs. The <jats:italic>Carya</jats:italic> locus contains ~20 syntenic genes and shows molecular signatures of sex chromosome–like evolution. Inheritance mechanisms for heterodichogamy are deeply conserved, yet may occasionally turn over, as in sex determination.","PeriodicalId":21678,"journal":{"name":"Science","volume":"4 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142917174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matthew N. Zipple, Daniel Chang Kuo, Xinmiao Meng, Tess M. Reichard, Kwynn Guess, Caleb C. Vogt, Andrew H. Moeller, Michael J. Sheehan
Contingency (or “luck”) in early life plays an important role in shaping individuals’ development. By comparing the developmental trajectories of functionally genetically identical free-living mice who either experienced high levels of resource competition (males) or did not (females), we show that competition magnifies early contingency. Male resource competition results in a feedback loop that magnifies the importance of early contingency and pushes individuals onto divergent, self-reinforcing life trajectories, while the same process appears absent in females. Our results indicate that the strength of sexual selection may be self-limiting, and they highlight the potential for contingency to lead to differences in life outcomes, even in the absence of any underlying differences in ability (“merit”).
{"title":"Competitive social feedback amplifies the role of early life contingency in male mice","authors":"Matthew N. Zipple, Daniel Chang Kuo, Xinmiao Meng, Tess M. Reichard, Kwynn Guess, Caleb C. Vogt, Andrew H. Moeller, Michael J. Sheehan","doi":"10.1126/science.adq0579","DOIUrl":"https://doi.org/10.1126/science.adq0579","url":null,"abstract":"Contingency (or “luck”) in early life plays an important role in shaping individuals’ development. By comparing the developmental trajectories of functionally genetically identical free-living mice who either experienced high levels of resource competition (males) or did not (females), we show that competition magnifies early contingency. Male resource competition results in a feedback loop that magnifies the importance of early contingency and pushes individuals onto divergent, self-reinforcing life trajectories, while the same process appears absent in females. Our results indicate that the strength of sexual selection may be self-limiting, and they highlight the potential for contingency to lead to differences in life outcomes, even in the absence of any underlying differences in ability (“merit”).","PeriodicalId":21678,"journal":{"name":"Science","volume":"20 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142917189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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