Exocytosis exposes Src at the outer surface of cancer cells, poised for therapeutic targeting.
胞吐将Src暴露在癌细胞的外表面，为靶向治疗做好准备。
{"title":"Extending the reach of a classic oncogene.","authors":"Alexander Pfannenstein,Tobias Meyer","doi":"10.1126/science.aef9956","DOIUrl":"https://doi.org/10.1126/science.aef9956","url":null,"abstract":"Exocytosis exposes Src at the outer surface of cancer cells, poised for therapeutic targeting.","PeriodicalId":21678,"journal":{"name":"Science","volume":"16 1","pages":"1103-1104"},"PeriodicalIF":56.9,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147439642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Claire N. Bedbrook, Ravi D. Nath, Libby Zhang, Scott W. Linderman, Anne Brunet, Karl Deisseroth
Mapping behavior of individual vertebrate animals across lifespan could provide an unprecedented view into the lifelong process of aging. We created a platform for high-resolution continuous behavioral tracking of the African killifish across natural lifespan from adolescence to death. We found that animals follow distinct individual aging trajectories. The behaviors of long-lived animals differed markedly from those of short-lived animals, even relatively early in life, and were linked to organ-specific transcriptomic shifts. Machine-learning models accurately inferred age and even forecasted an individual’s future lifespan, given only behavior at a young age. Finally, we found that animals progressed through adulthood in a sequence of stable and stereotyped behavioral stages with abrupt transitions, revealing precise structure for an architecture of aging.
{"title":"Lifelong behavioral screen reveals an architecture of vertebrate aging","authors":"Claire N. Bedbrook, Ravi D. Nath, Libby Zhang, Scott W. Linderman, Anne Brunet, Karl Deisseroth","doi":"10.1126/science.aea9795","DOIUrl":"https://doi.org/10.1126/science.aea9795","url":null,"abstract":"Mapping behavior of individual vertebrate animals across lifespan could provide an unprecedented view into the lifelong process of aging. We created a platform for high-resolution continuous behavioral tracking of the African killifish across natural lifespan from adolescence to death. We found that animals follow distinct individual aging trajectories. The behaviors of long-lived animals differed markedly from those of short-lived animals, even relatively early in life, and were linked to organ-specific transcriptomic shifts. Machine-learning models accurately inferred age and even forecasted an individual’s future lifespan, given only behavior at a young age. Finally, we found that animals progressed through adulthood in a sequence of stable and stereotyped behavioral stages with abrupt transitions, revealing precise structure for an architecture of aging.","PeriodicalId":21678,"journal":{"name":"Science","volume":"1 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147440475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"From field experiments to policy interventions at scale.","authors":"Imran Rasul","doi":"10.1126/science.aef8482","DOIUrl":"https://doi.org/10.1126/science.aef8482","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"95 1","pages":"eaef8482"},"PeriodicalIF":56.9,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147439322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rejecting ignorance as the cause of antibiotic overuse, a pair of sociologists find more likely explanations.
两位社会学家拒绝将无知作为抗生素过度使用的原因，他们找到了更可能的解释。
{"title":"Antimicrobial resistance in IndiaA World of Resistance Assa Doron and Alex Broom Belknap Press, 2026. 264 pp.","authors":"Aashima Dogra-Freitag","doi":"10.1126/science.aee7889","DOIUrl":"https://doi.org/10.1126/science.aee7889","url":null,"abstract":"Rejecting ignorance as the cause of antibiotic overuse, a pair of sociologists find more likely explanations.","PeriodicalId":21678,"journal":{"name":"Science","volume":"56 1","pages":"1107"},"PeriodicalIF":56.9,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147439333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ancient glacial ice melting out of Alaska's eroding coastline may offer the Northern Hemisphere's only glimpse into a pivotal climate chapter.
阿拉斯加海岸线被侵蚀，古冰川正在融化，这可能是北半球了解关键气候篇章的唯一机会。
{"title":"Frozen witness.","authors":"Evan Howell","doi":"10.1126/science.aeh0790","DOIUrl":"https://doi.org/10.1126/science.aeh0790","url":null,"abstract":"<p><p>Ancient glacial ice melting out of Alaska's eroding coastline may offer the Northern Hemisphere's only glimpse into a pivotal climate chapter.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"391 6790","pages":"1096-1099"},"PeriodicalIF":45.8,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147444677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yinan Wan, Jakob El Kholtei, Ignatius Jenie, Mariona Colomer-Rosell, Jialin Liu, Qinghua Zhang, Joaquin Navajas Acedo, Lucia Y. Du, Mireia Codina-Tobias, Mengfan Wang, Wei Zheng, Edward Lin, Tzy-Harn Chuang, Oded Mayseless, Ahilya Sawh, Susan E. Mango, Guoqiang Yu, Bogdan Bintu, Alexander F. Schier
Gene expression patterns underlie development, but their systematic detection in whole embryos has remained elusive. We introduce a whole-embryo imaging platform using multiplexed error-robust fluorescent in situ hybridization (weMERFISH). We quantified the expression of 495 genes in zebrafish embryos at subcellular resolution and generated an online atlas detailing the expression of 25,872 genes and accessibility of 294,954 chromatin regions during embryogenesis. Expression patterns often corresponded to composites of tissue-specific accessible elements, and expression changes aligned with cellular maturation and morphogenesis. Integration with live imaging revealed how similar expression patterns can emerge through different dynamics and showed that sharp boundaries develop through changes in gene expression rather than through cell sorting. These results establish multiplexed whole-embryo spatial transcriptomics and reveal the regulation and dynamics of embryonic gene expression patterns.
{"title":"Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis","authors":"Yinan Wan, Jakob El Kholtei, Ignatius Jenie, Mariona Colomer-Rosell, Jialin Liu, Qinghua Zhang, Joaquin Navajas Acedo, Lucia Y. Du, Mireia Codina-Tobias, Mengfan Wang, Wei Zheng, Edward Lin, Tzy-Harn Chuang, Oded Mayseless, Ahilya Sawh, Susan E. Mango, Guoqiang Yu, Bogdan Bintu, Alexander F. Schier","doi":"10.1126/science.adt3439","DOIUrl":"https://doi.org/10.1126/science.adt3439","url":null,"abstract":"Gene expression patterns underlie development, but their systematic detection in whole embryos has remained elusive. We introduce a whole-embryo imaging platform using multiplexed error-robust fluorescent in situ hybridization (weMERFISH). We quantified the expression of 495 genes in zebrafish embryos at subcellular resolution and generated an online atlas detailing the expression of 25,872 genes and accessibility of 294,954 chromatin regions during embryogenesis. Expression patterns often corresponded to composites of tissue-specific accessible elements, and expression changes aligned with cellular maturation and morphogenesis. Integration with live imaging revealed how similar expression patterns can emerge through different dynamics and showed that sharp boundaries develop through changes in gene expression rather than through cell sorting. These results establish multiplexed whole-embryo spatial transcriptomics and reveal the regulation and dynamics of embryonic gene expression patterns.","PeriodicalId":21678,"journal":{"name":"Science","volume":"8 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147440479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Joana Osório, Yevgeniya Nusinovich, Corinne Simonti, Mattia Maroso, Angela Hessler, Marc S Lavine, Jake S Yeston
Editors' selections from the current scientific literature.
编辑从当前的科学文献中选择。
{"title":"In Other Journals.","authors":"Joana Osório, Yevgeniya Nusinovich, Corinne Simonti, Mattia Maroso, Angela Hessler, Marc S Lavine, Jake S Yeston","doi":"10.1126/science.aeh0793","DOIUrl":"https://doi.org/10.1126/science.aeh0793","url":null,"abstract":"<p><p>Editors' selections from the current scientific literature.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"391 6790","pages":"1116-1117"},"PeriodicalIF":45.8,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147444742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matthias-Claudio Loretto,Kristina B Beck,Douglas W Smith,Daniel R Stahler,Lauren E Walker,Martin Wikelski,Thomas Mueller,Kamran Safi,John M Marzluff
Scavengers generally rely on patchily distributed, unpredictable carrion. A long-standing hypothesis suggests scavenging ravens reliably locate such food by directly following large carnivores to their kills. However, by satellite tracking 69 ravens, 20 wolves, and 11 cougars in Yellowstone National Park, we found that following of predators over large distances rarely occurred. Instead, ravens routinely revisited sites where wolf kills were common-returning from distances of up to 155 kilometers to find carrion. Much like navigating to permanent anthropogenic subsidies, ravens appear to remember potential sources of carrion shaped by previous encounters with wolves or their kills. These findings suggest that spatial memory and navigation play a considerably greater role than previously assumed among scavengers, and possibly other wide-ranging species, in search of ephemeral resources.
{"title":"Ravens anticipate wolf kill sites across broad scales.","authors":"Matthias-Claudio Loretto,Kristina B Beck,Douglas W Smith,Daniel R Stahler,Lauren E Walker,Martin Wikelski,Thomas Mueller,Kamran Safi,John M Marzluff","doi":"10.1126/science.adz9467","DOIUrl":"https://doi.org/10.1126/science.adz9467","url":null,"abstract":"Scavengers generally rely on patchily distributed, unpredictable carrion. A long-standing hypothesis suggests scavenging ravens reliably locate such food by directly following large carnivores to their kills. However, by satellite tracking 69 ravens, 20 wolves, and 11 cougars in Yellowstone National Park, we found that following of predators over large distances rarely occurred. Instead, ravens routinely revisited sites where wolf kills were common-returning from distances of up to 155 kilometers to find carrion. Much like navigating to permanent anthropogenic subsidies, ravens appear to remember potential sources of carrion shaped by previous encounters with wolves or their kills. These findings suggest that spatial memory and navigation play a considerably greater role than previously assumed among scavengers, and possibly other wide-ranging species, in search of ephemeral resources.","PeriodicalId":21678,"journal":{"name":"Science","volume":"106 1","pages":"1151-1154"},"PeriodicalIF":56.9,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147439329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
An updated visual assessment tool can bridge the gap between climate research and political action.
更新的视觉评估工具可以弥合气候研究与政治行动之间的差距。
{"title":"Thirty-six solutions to stabilize Earth's climate.","authors":"Haewon McJeon,Yang Ou","doi":"10.1126/science.aed5212","DOIUrl":"https://doi.org/10.1126/science.aed5212","url":null,"abstract":"An updated visual assessment tool can bridge the gap between climate research and political action.","PeriodicalId":21678,"journal":{"name":"Science","volume":"14 1","pages":"991-992"},"PeriodicalIF":56.9,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147359109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Melissa A Haendel,Ryan Ahern,Kasie B Bailey,Spyridon Bakas,Daniel C Barth-Jones,Alex Bohl,Jiang Bian,Philip E Bourne,Rebecca R Boyles,Christopher G Chute,James J Cimino,Shaun Grannis,Terry S Hartman,Michelle Holko,Nathan A Hotaling,Dan J Housman,Lawrence E Hunter,Eric Hurwitz,Jasmin Phua,Michael G Kahn,Dario Kuzmanovic,Josh Lemieux,Johanna Loomba,Charisse R Madlock-Brown,Kenneth D Mandl,Raja Mazumder,Julie A McMurry,Andrew J McMurry,Zubin J Modi,Richard A Moffitt,Abu S M Mosa,Nicholas Messina,Shawn T O'Neil,Josh F Peterson,Emily R Pfaff,Jimmy Phuong,Rachel Presskreischer,Lee Sanders,Abeed Sarker,Alastair Thomson,Kim M Unertl,Anita Walden,Jim Weinstein
The utility model offers a framework for ethical stewardship, patient empowerment, and distributed innovation.
本实用新型为伦理管理、患者授权和分布式创新提供了一个框架。
{"title":"Governing real-world health data as a public utility.","authors":"Melissa A Haendel,Ryan Ahern,Kasie B Bailey,Spyridon Bakas,Daniel C Barth-Jones,Alex Bohl,Jiang Bian,Philip E Bourne,Rebecca R Boyles,Christopher G Chute,James J Cimino,Shaun Grannis,Terry S Hartman,Michelle Holko,Nathan A Hotaling,Dan J Housman,Lawrence E Hunter,Eric Hurwitz,Jasmin Phua,Michael G Kahn,Dario Kuzmanovic,Josh Lemieux,Johanna Loomba,Charisse R Madlock-Brown,Kenneth D Mandl,Raja Mazumder,Julie A McMurry,Andrew J McMurry,Zubin J Modi,Richard A Moffitt,Abu S M Mosa,Nicholas Messina,Shawn T O'Neil,Josh F Peterson,Emily R Pfaff,Jimmy Phuong,Rachel Presskreischer,Lee Sanders,Abeed Sarker,Alastair Thomson,Kim M Unertl,Anita Walden,Jim Weinstein","doi":"10.1126/science.aeb1178","DOIUrl":"https://doi.org/10.1126/science.aeb1178","url":null,"abstract":"The utility model offers a framework for ethical stewardship, patient empowerment, and distributed innovation.","PeriodicalId":21678,"journal":{"name":"Science","volume":"31 1","pages":"993-996"},"PeriodicalIF":56.9,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147359113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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