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Protect kelp forests 保护海藻林
IF 44.7 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Science
Pub Date : 2024-11-07 DOI: 10.1126/science.adr4814
Nur Arafeh-Dalmau, Carolina Olguín-Jacobson, Sylvia Earle, Max Bello, Cristian Lagger, Alejandra Mora-Soto, Carolina Pantano, Mauricio Palacios, Romina Vanessa Barbosa, Eliseo Fica-Rojas, Eduardo Guajardo, Octavio Aburto-Oropeza, Aaron Eger, Paul Dayton, Anita Giraldo-Ospina, Kyle Cavanaugh, Jessica García-Pantoja, Gabriela Montaño-Moctezuma, Hugh Possingham, Enric Sala, David Schoeman, Guillermo Torres-Moye, Fiorenza Micheli
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引用次数: 0
Regulated N-glycosylation controls chaperone function and receptor trafficking 受调控的 N-糖基化控制着伴侣功能和受体迁移
IF 44.7 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Science
Pub Date : 2024-11-07 DOI: 10.1126/science.adp7201
Mengxiao Ma, Ramin Dubey, Annie Jen, Ganesh V. Pusapati, Bharti Singal, Evgenia Shishkova, Katherine A. Overmyer, Valérie Cormier-Daire, Juliette Fedry, L. Aravind, Joshua J. Coon, Rajat Rohatgi
One-fifth of human proteins are N-glycosylated in the endoplasmic reticulum (ER) by two oligosaccharyltransferases, OST-A and OST-B. Contrary to the prevailing view of N-glycosylation as a housekeeping function, we identified an ER pathway that modulates the activity of OST-A. Genetic analyses linked OST-A to HSP90B1, an ER chaperone for membrane receptors, and CCDC134, an ER luminal protein. During its translocation into the ER, an N-terminal peptide in HSP90B1 templates the assembly of a translocon complex containing CCDC134 and OST-A that protects HSP90B1 during folding, preventing its hyperglycosylation and degradation. Disruption of this pathway impairs WNT and IGF1R signaling and causes the bone developmental disorder osteogenesis imperfecta. Thus, N-glycosylation can be regulated by specificity factors in the ER to control cell surface receptor signaling and tissue development.
五分之一的人类蛋白质在内质网（ER）中由两种寡糖转移酶 OST-A 和 OST-B 进行 N-糖基化。与普遍认为 N-糖基化是一种看家功能的观点相反，我们发现了一种调节 OST-A 活性的 ER 通路。遗传分析将 OST-A 与 HSP90B1（一种用于膜受体的 ER 合子）和 CCDC134（一种 ER 管腔蛋白）联系起来。HSP90B1在转运到ER的过程中，其N端肽会模板化一个包含CCDC134和OST-A的转运体复合物，在折叠过程中保护HSP90B1，防止其过度糖基化和降解。这一途径的中断会影响 WNT 和 IGF1R 信号的传递，并导致骨骼发育障碍性成骨不全症。因此，N-糖基化可由ER中的特异性因子调控，从而控制细胞表面受体信号传导和组织发育。
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引用次数: 0
Ultrahigh–surface area covalent organic frameworks for methane adsorption 用于甲烷吸附的超高表面积共价有机框架
IF 44.7 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Science
Pub Date : 2024-11-07 DOI: 10.1126/science.adr0936
Ying Yin, Ya Zhang, Xu Zhou, Bo Gui, Wenqi Wang, Wentao Jiang, Yue-Biao Zhang, Junliang Sun, Cheng Wang
Developing porous materials with ultrahigh surface areas for gas storage (for example, methane) is attractive but challenging. Here, we report two isostructural three-dimensional covalent organic frameworks (COFs) with a rare self-catenated alb-3,6-Ccc2 topology and a pore size of 1.1 nanometer. Notably, these imine-linked microporous COFs show both high gravimetric Brunauer–Emmett–Teller (BET) surface areas (~4400 square meters per gram) and volumetric BET surface areas (~1900 square meters per cubic centimeter). Moreover, their volumetric methane uptake reaches up to 264 cubic centimeter (standard temperature and pressure) per cubic centimeter [cm3 (STP) cm−3] at 100 bar and 298 kelvin, and they exhibit the highest volumetric working capacity of 237 cm3 (STP) cm−3 at 5 to 100 bar and 298 kelvin among all reported porous crystalline materials.
开发具有超高比表面积的多孔材料用于储存气体（例如甲烷）具有吸引力，但也极具挑战性。在这里，我们报告了两种具有罕见的自卡特化 alb -3,6- Ccc 2 拓扑结构和 1.1 纳米孔径的等结构三维共价有机框架（COFs）。值得注意的是，这些亚胺连接的微孔 COF 同时显示出较高的重力布鲁纳-埃美特-泰勒（BET）表面积（约 4400 平方米/克）和体积 BET 表面积（约 1900 平方米/立方厘米）。此外，在 100 巴和 298 开尔文条件下，它们的体积甲烷吸收量高达每立方厘米 264 立方厘米（标准温度和压力）[cm 3 (STP) cm -3 ]，在 5 至 100 巴和 298 开尔文条件下，它们的体积工作容量为 237 cm 3 (STP) cm -3，是所有已报道的多孔晶体材料中最高的。
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引用次数: 0
A two-faced membrane channel 双面膜通道
IF 44.7 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Science
Pub Date : 2024-11-07 DOI: 10.1126/science.adt2513
Xing Yang, Mohammad Hossein Jandaghian
From treating wastewater to sorting biological components, the separation of oil and water from a complex mixture is relevant to processes across many industries and branches of science. Membranes are key components to separation techniques such as reverse osmosis, which is used to purify water. However, traditional membrane technologies are often limited to filtering only one component from a mixture, leaving the remaining liquid highly concentrated with residues such as salts and organic matter (1). This not only makes further separation challenging by increasing the thermodynamic stability of the materials left behind in the solution but also creates potential disposal hazards. On page 654 of this issue, Guo et al. (2) report the ingenious design of a membrane system that can simultaneously separate oil and water in a single stream from a surfactant-stabilized mixture. This strategy could be combined with other commercial membranes for a breadth of applications.
截然不同的表面特性激活了一个反馈循环系统，从而实现彻底的油水分离。
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引用次数: 0
Consistent H5N1 control needed for farm animals 需要对农场动物进行持续的 H5N1 控制。
IF 44.7 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Science
Pub Date : 2024-11-07 DOI: 10.1126/science.adr5181
Ilaria Capua, Angela Fanelli
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引用次数: 0
In Science Journals 在科学杂志上。
IF 44.7 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Science
Pub Date : 2024-11-07 DOI: 10.1126/science.adu3743
Ankit Walia, Catherine Charneski, Jake S. Yeston, Phil Szuromi, Jesse Smith, Stella M Hurtley, Bianca Lopez, Mattia Maroso, Annalisa M. VanHook, Di Jiang, Peter Stern, Sarah H. Ross, Caroline Ash, Marc S. Lavine, L. Bryan Ray, Claire Olingy
{"title":"In Science Journals","authors":"Ankit Walia,&nbsp;Catherine Charneski,&nbsp;Jake S. Yeston,&nbsp;Phil Szuromi,&nbsp;Jesse Smith,&nbsp;Stella M Hurtley,&nbsp;Bianca Lopez,&nbsp;Mattia Maroso,&nbsp;Annalisa M. VanHook,&nbsp;Di Jiang,&nbsp;Peter Stern,&nbsp;Sarah H. Ross,&nbsp;Caroline Ash,&nbsp;Marc S. Lavine,&nbsp;L. Bryan Ray,&nbsp;Claire Olingy","doi":"10.1126/science.adu3743","DOIUrl":"10.1126/science.adu3743","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6722","pages":""},"PeriodicalIF":44.7,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/science.adu3743","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case for altruistic cities 利他主义城市案例
IF 44.7 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Science
Pub Date : 2024-11-07 DOI: 10.1126/science.adt4139
Xuemei Bai
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引用次数: 0
When the war came 当战争来临时《禁园》：被围困列宁格勒的植物学家和他们不可能的选择》（The Botanists of Besieged Leningrad and Their Impossible Choice），Simon Parkin Scribner 出版社，2024 年。384 页。
IF 44.7 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Science
Pub Date : 2024-11-07 DOI: 10.1126/science.ads4204
Elizabeth Haswell
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引用次数: 0
Revisiting the mid-Pleistocene transition ocean circulation crisis 重新审视更新世中期过渡时期的海洋环流危机
IF 44.7 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Science
Pub Date : 2024-11-07 DOI: 10.1126/science.adn4154
Sophia K. V. Hines, Christopher D. Charles, Aidan Starr, Steven L. Goldstein, Sidney R. Hemming, Ian R. Hall, Nambiyathodi Lathika, Mollie Passacantando, Louise Bolge
The mid-Pleistocene transition (MPT) [~1.25 to 0.85 million years ago (Ma)] marks a shift in the character of glacial-interglacial climate (1, 2). One prevailing hypothesis for the origin of the MPT is that glacial deep ocean circulation fundamentally changed, marked by a circulation “crisis” at ~0.90 Ma (marine isotope stages 24 to 22) (3). Using high-resolution paired neodymium, carbon, and oxygen isotope data from the South Atlantic Ocean (Cape Basin) across the MPT, we find no evidence of a substantial change in deep ocean circulation. Before and during the early MPT (~1.30 to 1.12 Ma), the glacial deep ocean variability closely resembled that of the most recent glacial cycle. The carbon storage facilitated by developing deep ocean stratification across the MPT required only modest circulation adjustments.
中新世过渡（MPT）[约 125 万年前至 85 万年前（Ma）]标志着冰川-间冰期气候特征的转变 ( 1 , 2 ) 。关于冰川-间冰期的起源，一种流行的假说是冰川深海环流发生了根本性变化，其标志是在距今约 0.90 Ma（海洋同位素阶段 24 至 22）发生了环流 "危机" ( 3 )。利用南大西洋（开普盆地）跨越 MPT 的高分辨率成对钕同位素、碳同位素和氧同位素数据，我们没有发现深海环流发生重大变化的证据。在大冰期之前和早期（约 1.30 至 1.12 Ma），冰期深海的变化与最近一次冰期周期的变化非常相似。在整个MPT期间，深海分层的发展促进了碳储存，这只需要对环流进行适度的调整。
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引用次数: 0
In Other Journals 其他期刊。
IF 44.7 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Science
Pub Date : 2024-11-07 DOI: 10.1126/science.adu3744
Corinne Simonti, Priscilla N. Kelly, Yury Suleymanov, L. Bryan Ray, Caroline Ash, Keith T. Smith, Phil Szuromi
{"title":"In Other Journals","authors":"Corinne Simonti,&nbsp;Priscilla N. Kelly,&nbsp;Yury Suleymanov,&nbsp;L. Bryan Ray,&nbsp;Caroline Ash,&nbsp;Keith T. Smith,&nbsp;Phil Szuromi","doi":"10.1126/science.adu3744","DOIUrl":"10.1126/science.adu3744","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6722","pages":""},"PeriodicalIF":44.7,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/science.adu3744","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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