Qiang Li, Ren Liu, Zuwan Lin, Xinhe Zhang, Wenbo Wang, Israeli M. Galicia-Silva, Mai Liu, Zihan Gao, Samuel D. Pollock, Juan R. Alvarez-Dominguez, Jia Liu
Understanding how human pancreatic α and β cell electrical activities mature is critical for building fully functional stem cell–derived (SC-) pancreatic organoids for research and therapeutics. We implanted tissue-like, stretchable electronics during organogenesis of human pancreatic organoids, enabling months-long, single cell–resolved electrophysiology. Longitudinal single-cell tracking suggested that improved hormone responsiveness reflects increasing activity of SC-α and -β cells with low and high basal firing, linked to induction of energy and hormone metabolism genes. Daily metabolic entrainment showed that circadian hormone secretion rhythms reflect daily oscillation of SC-α and -β electrical characteristics, tied to induction of cell-cell communication and exocytic gene networks, revealing circadian coordination of cell-level, stimulus-coupled responses. Lastly, we showed that electrical stimulation, via implanted actuators, enhances SC-α and -β glucose responsiveness. Our results establish a bioelectronic framework to trace and modulate functional organoid maturation.
{"title":"Implanted flexible electronics reveal principles of human islet cell electrical maturation","authors":"Qiang Li, Ren Liu, Zuwan Lin, Xinhe Zhang, Wenbo Wang, Israeli M. Galicia-Silva, Mai Liu, Zihan Gao, Samuel D. Pollock, Juan R. Alvarez-Dominguez, Jia Liu","doi":"10.1126/science.aeb3295","DOIUrl":"https://doi.org/10.1126/science.aeb3295","url":null,"abstract":"Understanding how human pancreatic α and β cell electrical activities mature is critical for building fully functional stem cell–derived (SC-) pancreatic organoids for research and therapeutics. We implanted tissue-like, stretchable electronics during organogenesis of human pancreatic organoids, enabling months-long, single cell–resolved electrophysiology. Longitudinal single-cell tracking suggested that improved hormone responsiveness reflects increasing activity of SC-α and -β cells with low and high basal firing, linked to induction of energy and hormone metabolism genes. Daily metabolic entrainment showed that circadian hormone secretion rhythms reflect daily oscillation of SC-α and -β electrical characteristics, tied to induction of cell-cell communication and exocytic gene networks, revealing circadian coordination of cell-level, stimulus-coupled responses. Lastly, we showed that electrical stimulation, via implanted actuators, enhances SC-α and -β glucose responsiveness. Our results establish a bioelectronic framework to trace and modulate functional organoid maturation.","PeriodicalId":21678,"journal":{"name":"Science","volume":"8 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146222977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The detection limit of astronomical imaging observations is limited by several noise sources. Some of that noise is correlated between neighboring pixels and exposures, so in principle could be learned and corrected. We present the Astronomical Self-supervised Transformer-based Denoising (ASTERIS) algorithm, which integrates spatiotemporal information across multiple exposures. Benchmarking on mock data indicates that ASTERIS improves detection limits by 1.0 magnitude at 90% completeness and purity, while preserving the point spread function and photometric accuracy. Observational validation using data from the James Webb Space Telescope (JWST) and Subaru telescope identifies previously undetectable features, including low-surface-brightness galaxy structures and gravitationally-lensed arcs. Applied to deep JWST images, ASTERIS identifies three times more redshift ≳ 9 galaxy candidates than previous methods, with rest-frame ultraviolet luminosity 1.0 magnitude fainter.
{"title":"Deeper detection limits in astronomical imaging using self-supervised spatiotemporal denoising","authors":"Yuduo Guo, Hao Zhang, Mingyu Li, Fujiang Yu, Yunjing Wu, Yuhan Hao, Song Huang, Yongming Liang, Xiaojing Lin, Xinyang Li, Jiamin Wu, Zheng Cai, Qionghai Dai","doi":"10.1126/science.ady9404","DOIUrl":"https://doi.org/10.1126/science.ady9404","url":null,"abstract":"The detection limit of astronomical imaging observations is limited by several noise sources. Some of that noise is correlated between neighboring pixels and exposures, so in principle could be learned and corrected. We present the Astronomical Self-supervised Transformer-based Denoising (ASTERIS) algorithm, which integrates spatiotemporal information across multiple exposures. Benchmarking on mock data indicates that ASTERIS improves detection limits by 1.0 magnitude at 90% completeness and purity, while preserving the point spread function and photometric accuracy. Observational validation using data from the James Webb Space Telescope (JWST) and Subaru telescope identifies previously undetectable features, including low-surface-brightness galaxy structures and gravitationally-lensed arcs. Applied to deep JWST images, ASTERIS identifies three times more redshift ≳ 9 galaxy candidates than previous methods, with rest-frame ultraviolet luminosity 1.0 magnitude fainter.","PeriodicalId":21678,"journal":{"name":"Science","volume":"4 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146222985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Understanding how AI affects productivity has implications for labor markets.
了解人工智能如何影响生产力对劳动力市场有影响。
{"title":"AI raises the productivity bar.","authors":"Lingfei Wu, Bogdan Vasilescu","doi":"10.1126/science.aef5239","DOIUrl":"https://doi.org/10.1126/science.aef5239","url":null,"abstract":"<p><p>Understanding how AI affects productivity has implications for labor markets.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"391 6787","pages":"763-764"},"PeriodicalIF":45.8,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146228422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Microbes can help protect corn against a fearsome pest.","authors":"Erik Stokstad","doi":"10.1126/science.aeg5597","DOIUrl":"https://doi.org/10.1126/science.aeg5597","url":null,"abstract":"<p><p>Nontoxic approach bolsters plant's own defenses.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"391 6787","pages":"754-755"},"PeriodicalIF":45.8,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146228535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bio-nanoelectronic islets are new tools for diabetes research and therapy.
生物纳米电子胰岛是糖尿病研究和治疗的新工具。
{"title":"Cyborg pancreatic islet organoids.","authors":"Jochen Lang, Matthieu Raoux","doi":"10.1126/science.aef2219","DOIUrl":"https://doi.org/10.1126/science.aef2219","url":null,"abstract":"<p><p>Bio-nanoelectronic islets are new tools for diabetes research and therapy.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"391 6787","pages":"764-765"},"PeriodicalIF":45.8,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146228585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Imagining the rich lives of invertebrates","authors":"Barbara J. King","doi":"10.1126/science.aec2352","DOIUrl":"10.1126/science.aec2352","url":null,"abstract":"","PeriodicalId":21678,"journal":{"name":"Science","volume":"391 6786","pages":""},"PeriodicalIF":45.8,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146162933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
As the primary source for nitrogen fertilizer, ammonia (NH3) is critical for sustaining the global food supply. It is a key industrial chemical and an ideal zero-carbon energy carrier, with annual production exceeding 180 million tonnes worldwide (1). For more than a century, industrial ammonia production has been dominated by the Haber-Bosch process, which combines nitrogen (N2) with hydrogen (H2) under high temperatures (350° to 450°C) and pressures (15 to 20 MPa) and emits substantial amounts of carbon dioxide. A more sustainable route to ammonia synthesis is the lithium-mediated nitrogen reduction reaction, an electrochemical method that uses lithium metal to activate inert nitrogen gas from the atmosphere (1, 2), but this approach suffers from low efficiency and poor long-term stability. On page 724 of this issue, Zhang et al. (3) report a strategy to improve the efficiency of the nitrogen reduction reaction, producing ammonia under conditions relevant to industrial operation.
{"title":"Layered interface transports ions swiftly","authors":"Claudio Ampelli","doi":"10.1126/science.aee6886","DOIUrl":"10.1126/science.aee6886","url":null,"abstract":"<div >As the primary source for nitrogen fertilizer, ammonia (NH<sub>3</sub>) is critical for sustaining the global food supply. It is a key industrial chemical and an ideal zero-carbon energy carrier, with annual production exceeding 180 million tonnes worldwide (<i>1</i>). For more than a century, industrial ammonia production has been dominated by the Haber-Bosch process, which combines nitrogen (N<sub>2</sub>) with hydrogen (H<sub>2</sub>) under high temperatures (350° to 450°C) and pressures (15 to 20 MPa) and emits substantial amounts of carbon dioxide. A more sustainable route to ammonia synthesis is the lithium-mediated nitrogen reduction reaction, an electrochemical method that uses lithium metal to activate inert nitrogen gas from the atmosphere (<i>1</i>, <i>2</i>), but this approach suffers from low efficiency and poor long-term stability. On page 724 of this issue, Zhang <i>et al.</i> (<i>3</i>) report a strategy to improve the efficiency of the nitrogen reduction reaction, producing ammonia under conditions relevant to industrial operation.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"391 6786","pages":""},"PeriodicalIF":45.8,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146162950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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