Micro- and nanoparticle sizing is a crucial parameter in numerous fields, including nanoparticle-based diagnostics, water treatment and filtration, and the synthesis of micro- and nanoparticles. Accurate and reliable sizing is essential for understanding how it affects the properties of the final product. Various approaches for micro- and nanoparticle sizing have been developed. Recently, differential dynamic microscopy (DDM) has emerged as a technique that combines dynamic light scattering and microscopy to investigate particle sizing using a standard light microscope. However, conventional DDM systems are bulky, non-portable, and currently unable to determine the size distribution of multi-modal particles. We aimed to develop a smartphone-based differential dynamic microscopy system for non-destructive, label-free micro- and nanoparticle sizing. This device consists of a reversed lens mounted in 3D-printed material, creating a highly compact and cost-effective microscope for the proposed smartphone-based particle sizing platform. The device acquires a series of images of dispersed particles that experience Brownian motion in a solution, then analyzes them using a differential dynamic algorithm and a non-negative least-squares approach to determine size distribution within four minutes when six concurrent processes are utilized. The proposed smartphone-based demonstration showed that the device can determine the size of gold nanoparticles as small as 30 nm using a 10 µL sample volume, highlighting its potential for applications in nanoparticle-based diagnostics and micro- and nanomaterial synthesis.
扫码关注我们
求助内容:
应助结果提醒方式:
