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Spatiotemporal variability and trends in rainfall and temperature in the central highlands of Ethiopia 埃塞俄比亚中部高地降雨和温度的时空变化和趋势
IF 3.3 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-03-01 Epub Date: 2026-01-27 DOI: 10.1016/j.sciaf.2026.e03198
Marshet Tefera , Engdawork Assefa , Shiferaw Muleta
This study investigates the spatiotemporal variability and trends of rainfall and temperature in the Ejerie district, Ethiopia, focusing on the Dega and Weyina Dega agroecological zones. Gridded monthly rainfall data (1990–2020) and temperature records (1990–2018) from the Ethiopian Meteorology Institute were analyzed at a 4 × 4 km resolution. Variability was assessed using mean, standard deviation, coefficient of variation (CV), precipitation concentration index (PCI), and standardized rainfall anomaly (SRA). Trend analysis was conducted using the Mann–Kendall test (MK test) and innovative trend analysis (ITA). Results showed that Dega receives 1245 mm of annual rainfall, while Weyina Dega receives 907.8 mm, with both regions exhibiting low rainfall variability. Rainfall is concentrated in the summer season, followed by Belg and Bega, with notable monthly variability in November and December. The PCI analysis indicated irregular rainfall distributions, with Dega showing 87.09% irregular and 9.68% strongly irregular distributions, while Weyina Dega showed 83.87% irregular and 3.23% strongly irregular distributions. SRA analysis revealed that 83.27% of Dega and 84.48% of Weyina Dega did not experience drought, with minor drought occurrences observed in both regions. Temperature analysis showed significant seasonal differences, with Dega experiencing cooler temperatures than Weyina Dega, which has a warmer climate. Both the MK test and ITA methods yielded consistent temperature trends, with the exception of minor discrepancies in Bega season temperatures. These findings emphasize the importance of localized climate studies to inform area-specific adaptation strategies for agriculture and water resource management in the region and climate resilient livelihood.
本文研究了埃塞俄比亚Ejerie地区降雨和温度的时空变化及其趋势,重点研究了Dega和Weyina Dega农业生态区。来自埃塞俄比亚气象研究所的网格化月度降雨数据(1990-2020)和温度记录(1990-2018)以4 × 4公里的分辨率进行了分析。利用平均值、标准差、变异系数(CV)、降水浓度指数(PCI)和标准化降水异常(SRA)评估变异度。采用Mann-Kendall检验(MK检验)和创新趋势分析(ITA)进行趋势分析。结果表明,德加年降雨量为1245 mm,维纳德加年降雨量为907.8 mm,两者均表现出较低的降水变率。降雨集中在夏季,其次是Belg和Bega, 11月和12月的月变化显著。PCI分析显示降水分布不规则,其中德加的不规则分布占87.09%,强不规则分布占9.68%,魏义纳德加的不规则分布占83.87%,强不规则分布占3.23%。SRA分析显示,83.27%的Dega地区和84.48%的Weyina Dega地区未发生干旱,两个地区均有轻微干旱发生。温度分析显示出显著的季节差异,德加的温度低于气候温暖的维纳德加。MK测试和ITA方法都得到了一致的温度趋势,除了Bega季节温度的微小差异。这些发现强调了本地化气候研究的重要性,可以为该地区农业和水资源管理以及气候适应型生计的特定区域适应战略提供信息。
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引用次数: 0
Comparative evaluation of composting and solarization techniques for mitigating antibiotic residues, and resistance genes in poultry manure 堆肥和日光技术对减轻家禽粪便中抗生素残留和抗性基因的比较评价
IF 3.3 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-03-01 Epub Date: 2026-02-02 DOI: 10.1016/j.sciaf.2026.e03228
Paul Appiah Sekyere , David Azanu , Osei Akoto
The improper management of poultry waste poses a growing environmental and public health threat due to accumulation of antibiotic residues, pathogenic microorganisms, and antimicrobial resistance genes (ARGs). This study investigated the effectiveness of composting, open solarization, and closed solarization in transforming poultry manure into safer, nutrient-rich material for agricultural use. Poultry waste mixed with sawdust (2:1 w/w) was treated over 60 days, with weekly monitoring of physicochemical properties, microbial load, and concentrations of tetracycline, sulfamethoxazole, ampicillin, and neomycin sulphate. Composting achieved complete degradation (100%) of all antibiotics within 50 days. For closed solarisation, ampicillin was completely removed within 60 days, while the remaining antibiotics showed varying removal efficiencies. Antibiotic removal efficiencies for open solarization ranged from 93% to 97% within 60 days. Microbial loads declined significantly under composting and closed solarization, with composting reducing counts of Escherichia coli isolates from 1.15 × 10¹¹ CFU/mL to 9.29 × 10¹⁰ CFU/mL from untreated and early-stage compost samples. Antibiotic sensitivity tests revealed a reduction in ticarcillin-resistant E. coli from 50% to 17% post-treatment, and no new resistance was observed for amikacin, meropenem, and norfloxacin in composted samples. All treatments improved nutrient content, particularly potassium, which rose from 1.52% to 6.03% under composting. Statistical correlations show temperature and moisture significantly influenced antibiotic degradation and microbial reduction (p < 0.05). Closed solarization maintained better thermal and moisture conditions than open solarization, enhancing treatment efficacy. These results confirm composting and closed solarization as robust, climate-sensitive strategies for antibiotic residue mitigation, microbial safety, and sustainable nutrient recovery in poultry waste management.
由于抗生素残留、病原微生物和抗菌素耐药基因(ARGs)的积累,家禽粪便管理不当对环境和公共卫生构成日益严重的威胁。本研究探讨了堆肥、开放式日光和封闭式日光在将家禽粪便转化为更安全、营养丰富的农业材料方面的有效性。与木屑混合的家禽粪便(2:1 w/w)处理60天,每周监测其理化性质、微生物负荷以及四环素、磺胺甲恶唑、氨苄西林和硫酸新霉素的浓度。堆肥在50天内实现所有抗生素的完全降解(100%)。对于封闭日晒,氨苄西林在60天内被完全去除,而剩余的抗生素表现出不同的去除效率。开放辐照60天内抗生素去除效率为93% ~ 97%。在堆肥和封闭日晒下,微生物负荷显著下降,堆肥使未经处理和早期堆肥样品的大肠杆菌分离株数量从1.15 × 10¹CFU/mL减少到9.29 × 10¹CFU/mL。抗生素敏感性试验显示,对替卡西林耐药的大肠杆菌在处理后从50%减少到17%,并且在堆肥样品中未观察到对阿米卡星、美罗培南和诺氟沙星的新耐药性。各处理均提高了土壤养分含量,其中钾含量最高,堆肥处理的土壤钾含量由1.52%提高到6.03%。统计相关性显示温度和湿度显著影响抗生素降解和微生物减少(p < 0.05)。封闭光照比开放光照保持了更好的热、湿条件,提高了处理效果。这些结果证实,堆肥和封闭日光是在家禽废物管理中减少抗生素残留、微生物安全性和可持续养分回收的强大的、气候敏感的策略。
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引用次数: 0
Machine Learning– driven discovery and optimization of PI3Kδ inhibitors for diffuse large B-cell lymphoma 弥漫性大b细胞淋巴瘤PI3Kδ抑制剂的机器学习驱动发现和优化
IF 3.3 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-03-01 Epub Date: 2026-01-29 DOI: 10.1016/j.sciaf.2026.e03206
Josiah Joseph Isah , Adamu Uzairu , Sani Uba , Muhammad Tukur Ibrahim
Diffuse large B-cell lymphoma (DLBCL) remains difficult to treat, as current PI3Kδ inhibitors are limited by toxicity and poor metabolic stability. To address these challenges, we applied a machine learning (ML)–guided design framework integrating predictive quantitative structure–activity relationship (QSAR) modelling, absorption, distribution, metabolism, excretion, and toxicity (ADMET) profiling, molecular docking, and molecular dynamics simulations. A curated dataset of 3268 compounds was reduced to 9 descriptors, supporting a robust Random Forest model that achieved strong predictive performance on an external test set (R2 ≈ 0.63; concordance correlation coefficient (CCC) ≈ 0.76), while maintaining high training set fit (R2 = 0.94). This indicates good generalization to unseen compounds. Scaffold prioritization nominated Compound 9, which showed strong docking affinity (–9.5 kcal/mol) and favourable pharmacokinetic predictions. Guided optimization produced analogues 9a–9c, of which 9b demonstrated superior absorption (96.6%), reduced CNS penetration, and stable hydrogen bonding with VAL828 in 100-ns molecular dynamics (MD) simulations (root-mean-square deviation [RMSD] ∼1.2–1.8 Å). Molecular mechanics–generalized Born surface area (MM-GBSA) analysis confirmed favourable binding free energy (–77.6 kcal/mol), with 9b achieving enhanced stability through balanced energetic contributions. Collectively, these results highlight Compound 9b as a computationally prioritized lead for further experimental evaluation and illustrate the power of machine learning–driven, simulation-validated pipelines in accelerating kinase inhibitor discovery for aggressive lymphomas. Experimental validation is needed to confirm these predictions.
弥漫性大b细胞淋巴瘤(DLBCL)仍然难以治疗,因为目前的PI3Kδ抑制剂受毒性和代谢稳定性差的限制。为了应对这些挑战,我们应用了一个机器学习(ML)指导的设计框架,集成了预测定量结构-活性关系(QSAR)建模、吸收、分布、代谢、排泄和毒性(ADMET)分析、分子对接和分子动力学模拟。将3268种化合物的数据集减少到9个描述符,支持鲁棒随机森林模型,该模型在外部测试集上获得了很强的预测性能(R2≈0.63;一致性相关系数(CCC)≈0.76),同时保持了较高的训练集拟合(R2 = 0.94)。这表明对看不见的化合物有很好的泛化。支架优先推荐化合物9,它具有很强的对接亲和力(-9.5 kcal/mol)和良好的药代动力学预测。指导优化产生了类似物9a-9c,其中9b在100-ns分子动力学(MD)模拟中表现出更好的吸收(96.6%),降低了CNS穿透,并与VAL828形成稳定的氢键(均方根偏差[RMSD] ~ 1.2-1.8 Å)。分子力学-广义Born表面积(MM-GBSA)分析证实了良好的结合自由能(-77.6 kcal/mol), 9b通过平衡的能量贡献增强了稳定性。总的来说,这些结果突出了化合物9b作为进一步实验评估的计算优先先导,并说明了机器学习驱动,模拟验证管道在加速发现侵袭性淋巴瘤激酶抑制剂方面的力量。需要实验验证来证实这些预测。
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引用次数: 0
Clean coal technologies as transitional buffers in South Africa’s just energy transition: Safeguarding livelihood amid decarbonisation 清洁煤炭技术作为南非能源转型的过渡缓冲:在脱碳中保障生计
IF 3.3 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-03-01 Epub Date: 2026-01-29 DOI: 10.1016/j.sciaf.2026.e03210
Chandima Gomes
South Africa’s heavy dependence on coal, which supplies more than 85% of electricity generation and sustains over 90,000 direct mining jobs, places the country at the centre of the global challenge of reconciling decarbonisation with socioeconomic stability. This paper critically examines the role of Clean Coal Technologies (CCTs) as transitional buffers within South Africa’s Just Energy Transition (JET) framework. Using comparative case studies from China, the United States, India, and Australia, and integrating techno-economic indicators, lifecycle emissions, and employment metrics, the analysis evaluates the extent to which CCTs can moderate job losses while reducing carbon intensity. The technologies assessed include amine-based carbon capture (efficiency loss of approximately 9.5 percentage points and costs around USD 61/tCO₂), calcium looping (efficiency penalty of about 6.7–7.9%), and coal-to-hydrogen hybrid systems achieving up to 90% CO₂ removal under specific configurations. The results indicate that although CCTs can deliver short-term emissions reductions and employment continuity, their contribution is constrained by high retrofit costs (USD 500–1,200/kW), partial decarbonisation, and limited scalability. Renewable energy pathways, by comparison, offer higher employment multipliers, lower levelised costs of electricity, and substantial environmental and health co-benefits, but require extensive reskilling and institutional reform. The study concludes that CCTs may serve a strictly time-bound strategic role in coal-dependent regions such as Mpumalanga and Limpopo, provided they are embedded within explicit exit strategies and complemented by investments in workforce transition, decentralised renewables, and economic diversification.
南非对煤炭的严重依赖,提供了85%以上的发电量,并维持了9万多个直接采矿工作岗位,使该国处于协调脱碳与社会经济稳定的全球挑战的中心。本文批判性地考察了清洁煤炭技术(cct)在南非能源转型(JET)框架内作为过渡缓冲的作用。通过对中国、美国、印度和澳大利亚的比较案例研究,并整合技术经济指标、生命周期排放和就业指标,本分析评估了有条件现金转移支付在降低碳强度的同时缓解就业损失的程度。评估的技术包括胺基碳捕集(效率损失约9.5个百分点,成本约61美元/tCO₂)、钙环(效率损失约6.7-7.9%)和煤氢混合系统,在特定配置下可去除高达90%的CO₂。结果表明,尽管cct可以实现短期减排和就业连续性,但其贡献受到高改造成本(500 - 1200美元/千瓦)、部分脱碳和有限的可扩展性的限制。相比之下,可再生能源途径提供了更高的就业乘数,更低的电力成本,以及大量的环境和健康协同效益,但需要广泛的再培训和体制改革。该研究的结论是,有条件现金转移支付可能在普马兰加省和林波波省等依赖煤炭的地区发挥严格有时限的战略作用,前提是将其纳入明确的退出战略,并辅以对劳动力转型、分散式可再生能源和经济多样化的投资。
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引用次数: 0
Exploration of novel molecular inhibitors for Monkeypox virus with a fragment-based drug design approach 利用基于片段的药物设计方法探索猴痘病毒的新型分子抑制剂
IF 3.3 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-03-01 Epub Date: 2026-02-03 DOI: 10.1016/j.sciaf.2026.e03223
Amine Ballari , Rachid Haloui , Khadija Khaddam Allah , Kaouakeb El Khattabi , Abdelmoula El Abbouchi , Samir Chtita , Souad El khattabi
In August 2024, the world health organization declared Monkeypox virus (MPXV) a public health emergency of international interest due to a significant increase in reported cases and the number of deaths. The MPXV is a transmissible disease spreading from animals to people via scratches, bites, or as food, then people spread it to other people by close contact including sexual activities, massages, kissing, day-to-day household contact, and caring for people with MPXV. This work aims to find novel MPXV receptor inhibitors with an application of fragment-based drug design strategy. A screening of >269,000 fragments from various online data bases has been conducted to determine their affinity for binding MPXV. Employing the 2022 version of Schrödinger software, a total number of 1600 fragments with the highest docking scores have been submitted to a fragment linking to generate 100 new molecules. The MPXV binding affinity and ADMET features of the top10 docking score ligands were then examined in more comprehensive detail. Lastly, the appropriate ligands were chosen for a molecular dynamics study in order to evaluate the stability of the ligand-receptor complex in the best three molecules. The discovered ligands might be investigated further in the field of Monkeypox inhibitor drug development.
2024年8月,由于报告病例和死亡人数大幅增加,世界卫生组织宣布猴痘病毒(MPXV)为国际关注的突发公共卫生事件。MPXV是一种传染性疾病,通过动物的抓伤、咬伤或食物传播给人类,然后人们通过性行为、按摩、亲吻、日常家庭接触和照顾MPXV患者等密切接触将其传播给其他人。本研究旨在利用基于片段的药物设计策略寻找新型MPXV受体抑制剂。从各种在线数据库中筛选了269,000个片段,以确定它们与MPXV结合的亲和力。利用2022版Schrödinger软件,总共有1600个最高对接分数的片段提交给片段链接,以产生100个新分子。然后更全面详细地研究了top10对接评分配体的MPXV结合亲和力和ADMET特征。最后,选择合适的配体进行分子动力学研究,以评价配体-受体复合物在最佳的三个分子中的稳定性。发现的配体可能在猴痘抑制剂药物开发领域进行进一步的研究。
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引用次数: 0
Effect of simultaneous frying of food items on the concentrations and risks of PAHs in edible oils 同时煎炸食物对食用油中多环芳烃浓度及风险的影响
IF 3.3 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-03-01 Epub Date: 2026-01-30 DOI: 10.1016/j.sciaf.2026.e03209
Ufuoma A. Igbuku , Eze W. Odali , Beatrice O. Peretiemo-Clarke , Chinedu J. Ossai , Chukwujindu M.A. Iwegbue , Godwin E. Nwajei , Bice S. Martincigh
This study evaluated the effect of simultaneous frying of food items on the concentrations and risks of PAHs in different types of frying oils. The PAH concentrations of these oils were quantified prior to frying and after each frying cycle by gas chromatography-mass spectrometry (GC–MS). The Ʃ16 PAH concentrations in the oils before and after frying ranged from 20 to 120 µg kg-1 and 30 to 250 µg kg-1 respectively. There were substantial changes in the concentrations of individual PAHs and homologues in these edible oils after four frying cycles. The changes in the PAH concentrations after the frying series were in the sequence of palm olien (POL) > soybean oil (SBO) > groundnut oil (GNO) > coconut oil (CNO) > canola oil (CAO) > sunflower oil. (SFO) > olive oil (OLO) > palm oil (PMO). The observed order is controlled by the interplay among antioxidant composition, degree of unsaturation, and smoke point of the oils. The average changes in the Σ16 PAH concentrations of oil used repetitively for simultaneous frying of different food items were by far higher than the average changes in the PAH concentrations of oil used repetitively for frying of a single food item. The concentrations of the high molecular weight PAHs in the unfried and fried oils were above the limits of 2 µg kg-1 and 5 µg kg-1 for the individual PAHs and their sum, respectively, set by the European Union. The incremental lifetime carcinogenic risk (ILCR) assessment resulting from the ingestion of the unfried and fried edible oils indicates low carcinogenic risk.
本研究评估了同时煎炸食品对不同类型煎炸油中多环芳烃的浓度和风险的影响。用气相色谱-质谱联用(GC-MS)法测定了这些油在煎炸前和每次煎炸后的多环芳烃浓度。油炸前后油脂中Ʃ16多环芳烃含量分别为20 ~ 120µg kg-1和30 ~ 250µg kg-1。经过四个油炸循环后,这些食用油中单个多环芳烃及其同系物的浓度发生了实质性变化。油炸前后多环芳烃(PAH)浓度的变化顺序为:棕榈仁(POL) >;大豆油(SBO) >;花生油(GNO) >;椰子油(CNO) >;菜籽油(CAO) >;葵花籽油。(SFO)橄榄油(OLO)和棕榈油(PMO)。观察到的顺序是由油的抗氧化成分、不饱和程度和烟点之间的相互作用控制的。同时煎炸不同食物所重复使用的油中Σ16多环芳烃浓度的平均变化远远高于煎炸单一食物所重复使用的油中多环芳烃浓度的平均变化。未煎炸油和煎炸油中高分子量多环芳烃的浓度分别超过欧盟规定的单个多环芳烃及其总和2µg kg-1和5µg kg-1的限值。食用未油炸和油炸的食用油的终生致癌风险增量(ILCR)评估结果表明,其致癌风险较低。
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引用次数: 0
Synergistic in vitro anticancer activity of doxorubicin-betulinic acid against neuroblastoma (SH-SY5Y) and lung carcinoma (A549) supported by in silico targeting of ALK 阿霉素-白桦酸对神经母细胞瘤(SH-SY5Y)和肺癌(A549)体外协同抗癌活性的硅靶向ALK支持
IF 3.3 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-03-01 Epub Date: 2026-02-27 DOI: 10.1016/j.sciaf.2026.e03285
Joel Ojogbane Onoja , Pirun Mikled , Jude Y. Betow , Warinthorn Chavasiri
Neuroblastoma, a heterogeneous pediatric malignancy of neural crest origin, continues to exhibit poor prognosis in high-risk cases despite advances in multimodal therapy. Likewise, lung cancer, particularly non–small-cell lung carcinoma (NSCLC), frequently develops resistance to conventional chemotherapeutic agents. These challenges highlight the urgent need for novel therapeutic strategies with improved safety, selectivity, and the ability to target key molecular drivers of tumor progression. Combination approaches involving standard chemotherapeutics and bioactive phytochemicals represent a promising avenue for enhancing anticancer efficacy. In this study, betulinic acid (BA) was isolated for the first time from the ethyl acetate extract of Erythrophleum suaveolens (Guill. & Perr.) Brenan using column chromatography and thin-layer chromatography. Structural characterization was achieved through spectroscopic analyses, including 1H-2D NMR and EI-MS. The cytotoxic activity of BA was evaluated using cell viability assays against SH-SY5Y human neuroblastoma and A549 human lung carcinoma cell lines, with doxorubicin (DOX) employed as a reference drug. Furthermore, molecular docking studies were conducted to investigate the interaction of BA with human anaplastic lymphoma kinase (ALK) in complex with crizotinib (PDB ID: 2XP2). Betulinic acid (3β‑hydroxy-lup-20(29)-en-28-oic acid) exhibited significant cytotoxic activity against both cancer cell lines. In SH-SY5Y cells, BA demonstrated an IC₅₀ value of 61.65 ± 2.74 µM, markedly lower than that of doxorubicin (212.9 ± 32.63 µM), indicating superior potency. In A549 cells, BA showed an IC₅₀ of 26.86 ± 1.41 µM, comparable to doxorubicin (22.02 ± 3.14 µM). Notably, BA significantly potentiated DOX-induced cytotoxicity, particularly in SH-SY5Y cells, suggesting a strong chemosensitizing effect. Molecular docking revealed that BA binds within the ALK active site with a moderate binding energy (−5.149 kcal/mol), compared with crizotinib (−9.784 kcal/mol) and doxorubicin (−7.119 kcal/mol) supporting ALK as a potential molecular target. Overall, these findings highlight betulinic acid as a promising natural-product scaffold with chemosensitizing potential and warrant further mechanistic and in vivo investigations toward its development for pediatric and adult oncology.
神经母细胞瘤是一种起源于神经嵴的异质性儿童恶性肿瘤,尽管多模式治疗取得了进展,但在高危病例中,神经母细胞瘤的预后仍然很差。同样,肺癌,特别是非小细胞肺癌(NSCLC),经常对常规化疗药物产生耐药性。这些挑战凸显了迫切需要新的治疗策略,提高安全性、选择性和靶向肿瘤进展的关键分子驱动因素的能力。结合标准化疗药物和生物活性植物化学物质的方法是提高抗癌疗效的有希望的途径。本研究首次从红血球(Erythrophleum suaveolens)的乙酸乙酯提取物中分离得到白桦酸(BA)。和穗青葱)。布伦南采用柱层析和薄层层析。结构表征通过光谱分析,包括1H-2D NMR和EI-MS。以多柔比星(DOX)为对照药物,采用SH-SY5Y人神经母细胞瘤和A549人肺癌细胞系细胞活力测定法评价BA的细胞毒活性。此外,我们还进行了分子对接研究,研究BA与人间变性淋巴瘤激酶(ALK)与克唑替尼(PDB ID: 2XP2)复合物的相互作用。白桦酸(3β -羟基-lup-20(29)-en-28-oic酸)对两种癌细胞均表现出显著的细胞毒活性。在SH-SY5Y细胞中,BA的IC₅0值为61.65±2.74µM,明显低于阿霉素(212.9±32.63µM),表明其效力更强。在A549细胞中,BA显示IC₅0为26.86±1.41µM,与阿霉素(22.02±3.14µM)相当。值得注意的是,BA显著增强了dox诱导的细胞毒性,特别是在SH-SY5Y细胞中,这表明BA具有很强的化学增敏作用。分子对接发现,BA结合在ALK活性位点内,结合能适中(- 5.149 kcal/mol),而支持ALK的克唑替尼(- 9.784 kcal/mol)和阿霉素(- 7.119 kcal/mol)是潜在的分子靶点。总的来说,这些发现强调了白桦酸作为一种具有化学致敏潜力的有前途的天然产物支架,并为其在儿童和成人肿瘤中的发展提供了进一步的机制和体内研究。
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引用次数: 0
MultiModal-ArabicNER: A deep learning framework for semantic knowledge extraction from degraded historical arabic manuscripts MultiModal-ArabicNER:一个从退化的阿拉伯历史手稿中提取语义知识的深度学习框架
IF 3.3 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-03-01 Epub Date: 2026-02-14 DOI: 10.1016/j.sciaf.2026.e03257
Hassan Hazimze, Salma Gaou, Khalid Akhlil
Historical Arabic manuscripts represent invaluable cultural heritage that remains computationally inaccessible due to physical degradation and linguistic complexity. Existing approaches treat document enhancement and semantic analysis as separate stages, limiting their effectiveness on severely degraded texts. This paper introduces a novel multimodal framework that uniquely integrates degradation-aware feature fusion with hierarchical Arabic morphological analysis throughout the entire processing pipeline. Our methodology combines multi-scale document enhancement, specialized named entity recognition, and graph-based relation extraction specifically adapted for Classical Arabic texts. Extensive experiments on the VML-HD dataset demonstrate significant improvements: document enhancement achieves 32.4 dB PSNR and 0.891 SSIM, hierarchical NER attains F1-score of 0.792 (5.5 % improvement), and relation extraction reaches F1-score of 0.683 (4.1 % improvement over baselines). Cross-dataset evaluation shows performance variation across different manuscript collections, with domain adaptation techniques helping to maintain reasonable effectiveness. Our findings indicate that integrating visual and textual features at multiple processing stages supports the analysis of historical Arabic manuscripts. This approach facilitates computational analysis of Arabic manuscript collections, supporting digital humanities and cultural heritage preservation efforts.
历史上的阿拉伯手稿是无价的文化遗产,由于物理退化和语言复杂性,仍然无法通过计算获得。现有的方法将文档增强和语义分析作为单独的阶段,限制了它们在严重退化的文本上的有效性。本文介绍了一种新的多模态框架,该框架独特地将退化感知特征融合与分层阿拉伯语形态分析集成在整个加工管道中。我们的方法结合了多尺度文档增强、专门的命名实体识别和专门适用于古典阿拉伯文本的基于图的关系提取。在VML-HD数据集上的大量实验证明了显著的改进:文档增强达到32.4 dB PSNR和0.891 SSIM,分层NER达到F1-score 0.792(提高5.5 %),关系提取达到F1-score 0.683(比基线提高4.1 %)。跨数据集评估显示了不同手稿集的性能差异,领域自适应技术有助于保持合理的有效性。我们的研究结果表明,在多个处理阶段整合视觉和文本特征支持对历史阿拉伯手稿的分析。这种方法促进了阿拉伯手稿收藏的计算分析,支持数字人文和文化遗产保护工作。
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引用次数: 0
Using factor analysis and regression technique to predict cost overrun in road network construction projects 运用因子分析和回归技术对路网建设项目成本超支进行预测
IF 3.3 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-03-01 Epub Date: 2026-01-02 DOI: 10.1016/j.sciaf.2025.e03172
Taher Ammar , Mohamed Abdel-Monem , Karim El-Dash
Road construction projects in Egypt, as in many other developing African countries, frequently experience significant cost overruns. This study systematically analyzes the causes of such overruns to enhance understanding and improve risk management practices in the field. The research identifies key factors contributing to cost overruns and examines their relationships. A prediction model was developed to help estimate appropriate contingency costs by evaluating the impact of these factors on the overall project cost. Using Factor Analysis (FA), Regression Analysis (RA), and Regression Model (RM), the study assessed the significance of various cost overrun factors. The findings indicate that poor material quality, scope-of-work changes, and quantity variations are the primary causes of cost overruns in road construction projects. This study benefits both local and international researchers and practitioners by providing actionable insights. It highlights the practical implications of the findings and emphasizes key features that decision-makers should consider to improve the performance of the road network construction sector. As a critical driver of urban development and modern community establishment, enhancing the efficiency of road construction is essential for sustainable growth and infrastructure development. The study also helps the government address the risks associated with road network projects during the pre-tendering phase, enabling it to better manage its financial resources.
同许多其他非洲发展中国家一样,埃及的道路建设项目经常出现大量超支的情况。本研究系统地分析了此类超支的原因,以增强对该领域风险管理实践的理解和改进。该研究确定了导致成本超支的关键因素,并考察了它们之间的关系。开发了一个预测模型,通过评估这些因素对整个项目成本的影响来帮助估计适当的应急成本。运用因子分析(FA)、回归分析(RA)和回归模型(RM)对各成本超支因素的重要性进行了评估。研究结果表明,材料质量差、工程范围变化和数量变化是道路建设项目成本超支的主要原因。这项研究提供了可行的见解,对本地和国际研究人员和从业人员都有好处。它强调了研究结果的实际意义,并强调了决策者应该考虑的关键特征,以提高道路网络建设部门的绩效。道路建设是城市发展和现代社区建设的重要动力,提高道路建设效率对实现可持续增长和基础设施建设至关重要。这项研究亦有助政府在招标前阶段处理与道路网工程有关的风险,使政府能更妥善地管理财政资源。
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引用次数: 0
Short-term PV plant power forecasting model using CNN-GRU with XGBoost algorithm 基于XGBoost算法的CNN-GRU短期光伏电站功率预测模型
IF 3.3 Q2 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-03-01 Epub Date: 2026-01-11 DOI: 10.1016/j.sciaf.2026.e03184
Lahoucine Oumiguil, Ali Nejmi
Accurate short-term forecasting of photovoltaic (PV) power output is crucial for the efficient integration and operation of PV systems in smart grids. However, the intrinsic unpredictability and hierarchical discontinuity of PV data complicate the attainment of good predictive accuracy through conventional regression procedures. This research introduces a combined deep learning and gradient boosting model for short-term PV power forecasting. A convolutional neural network (CNN) is initially utilized to get important spatial features from input variables. Then, these features are coupled with historical PV power measurements in a gated recurrent unit (GRU) to capture temporal dependencies. The XGBoost technique is also used to represent complex nonlinear relationships in the data, which makes predictions even more accurate. The model is tested using actual PV plant data and gets a R² of 0.79, an RMSE of 23.30 MW, and a MAPE of 16.68%. These improvements show that the hybrid model works well to make predictions more accurate and reliable for real-world use.
准确的光伏发电输出短期预测对于智能电网中光伏系统的高效集成和运行至关重要。然而,PV数据固有的不可预测性和层次不连续性使传统回归方法难以获得良好的预测精度。本文介绍了一种结合深度学习和梯度增强的短期光伏发电功率预测模型。首先利用卷积神经网络(CNN)从输入变量中获取重要的空间特征。然后,将这些特征与门控循环单元(GRU)中的历史PV功率测量相结合,以捕获时间依赖性。XGBoost技术还用于表示数据中的复杂非线性关系,这使得预测更加准确。利用实际光伏电站数据对模型进行了检验,得到R²为0.79,RMSE为23.30 MW, MAPE为16.68%。这些改进表明,混合模型可以很好地使预测更准确、更可靠地用于现实世界。
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引用次数: 0
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Scientific African
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