Studies focusing on the spatiotemporal distribution of climatic parameters and meteorological drought are of paramount significance for countries like Ethiopia, where climate change and variability cause major losses to rain-dependent agriculture. In this study, the National Meteorology Institute of Ethiopia provided an Enhanced National Climate Services (ENACTS) dataset at a spatial resolution of approximately 4 km by 4 km over 38 years (1981–2018) was used to study climate trends, spatiotemporal variability, and meteorological drought in the Central Ethiopia Region. Coefficient of variation (CV), Standardized Rainfall Anomaly (SRA), Standardized Precipitation Index (SPI), Mann-Kendall trend test, and Sen's slope were used for the analysis. The findings suggest that Belg rainfall (also known as "small-rain") varied greatly in space and time over the study area, with area-averaged CV of 29 % and pixel-level CVs ranging from 63 to 93 %. The average precipitation during Belg experienced a 15 % decrease from 2000 to 2019 compared to the preceding two decades, from 1981 to 1999. The maximum temperature has increased significantly during the Annual, Belg, and Bega seasons. The SPI and SRA showed that there have been multiple drought episodes with rising negative rainfall anomalies, with a drought occurring every 2.9 years during the Kiremt (also called "big rain", spanning from June to September) and Belg seasons. The growing negative rainfall anomaly, high CV, and highly significant increase in mean maximum temperature during the Belg season is concerning for food security and poverty eradication. The notable rise in rainfall during the June (sowing period) and November (harvesting period) also hurts crop production during the main cropping season. Thus, developing appropriate adaptation strategies and policies oriented toward climate-resilient agriculture is crucial to meet the global sustainable development goals (SDGs) and Africa Union's Agenda 2063.