Eunseo Kim, Sanghun Lee, Hyungryul Yang, Makoto Hashimoto, Donghui Lu, Jongho Park, Changyoung Kim, Dirk Wulferding, Sunghun Kim, Doohee Cho
Two-dimensional (2D) materials inherently exhibit instabilities. Structurally, this may lead to modulations along the third dimension, e.g., wrinkles. Electronically, 2D instabilities can manifest themselves as charge density waves (CDWs). Although wrinkles can alter anisotropic electronic structures susceptible to forming CDWs, less is known about their impact on broken-symmetry ground states. Here, using scanning tunneling microscopy and spectroscopy, we investigate the CDW states on the wrinkled surface of DyTe3. We identify elongated, parallel nanoscale wrinkles stabilized by ribbon-shaped defects. Interestingly, the CDW order persists across the nanowrinkles with a gradual phase shift but is locally suppressed near the defects, where phase windings occur. In addition, these defects induce quantum confinement effects along the nanowrinkles, indicating the presence of one-dimensional metallic states with hole-like dispersion, while angle-resolved photoemission spectroscopy identifies a gap along the wrinkle direction. We ascribe this discrepancy to strain-induced changes in the Fermi surface, which lead to the closure of the gap at the sites of the nanowrinkles. Taken together, our results underscore the complex interplay between structural features and Fermi surface topology, allowing for the deliberate manipulation of quantum states in strongly correlated systems via local crystal deformations.
{"title":"One-Dimensional Electron Gas Confined along Nanowrinkles in a Unidirectional Charge Density Wave Material","authors":"Eunseo Kim, Sanghun Lee, Hyungryul Yang, Makoto Hashimoto, Donghui Lu, Jongho Park, Changyoung Kim, Dirk Wulferding, Sunghun Kim, Doohee Cho","doi":"10.1021/acsnano.4c18943","DOIUrl":"https://doi.org/10.1021/acsnano.4c18943","url":null,"abstract":"Two-dimensional (2D) materials inherently exhibit instabilities. Structurally, this may lead to modulations along the third dimension, e.g., wrinkles. Electronically, 2D instabilities can manifest themselves as charge density waves (CDWs). Although wrinkles can alter anisotropic electronic structures susceptible to forming CDWs, less is known about their impact on broken-symmetry ground states. Here, using scanning tunneling microscopy and spectroscopy, we investigate the CDW states on the wrinkled surface of DyTe<sub>3</sub>. We identify elongated, parallel nanoscale wrinkles stabilized by ribbon-shaped defects. Interestingly, the CDW order persists across the nanowrinkles with a gradual phase shift but is locally suppressed near the defects, where phase windings occur. In addition, these defects induce quantum confinement effects along the nanowrinkles, indicating the presence of one-dimensional metallic states with hole-like dispersion, while angle-resolved photoemission spectroscopy identifies a gap along the wrinkle direction. We ascribe this discrepancy to strain-induced changes in the Fermi surface, which lead to the closure of the gap at the sites of the nanowrinkles. Taken together, our results underscore the complex interplay between structural features and Fermi surface topology, allowing for the deliberate manipulation of quantum states in strongly correlated systems via local crystal deformations.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"29 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143849663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jiazheng Chen, Arijit Sarkar, Md Sazzadur Rahman, Victoria Ravel, Aaron D. Franklin, Tania Roy
Emerging neuromorphic systems offer a promising alternative for memory and sensing compared to traditional configurations, but face challenges with scalability and energy efficiency. Capacitive memories show great potential for addressing energy concerns due to their leakage-free nature. However, there is a lack of research on their scalability and robustness. In this work, we present a high-yield memcapacitor array that demonstrates reliable memory characteristics while also being capable of precisely sensing different types of vehicle motion with only a few picowatts of power consumption. Featuring a metal-oxide-semiconductor (MOS) structure with the most aggressively scaled dimensions compared to previously reported memcapacitors, we successfully established a 9 × 9 memcapacitor matrix with a yield of over 92.5%. The device exhibits tunable synaptic plasticity under varying pulsing schemes. We also demonstrate 64 distinct capacitance states and stable performance over 2 × 104 electrical pulses. Additionally, we showcase its application in motion sensing for autonomous vehicles, leveraging the short-term potentiation properties of the device. This approach offers a scalable, energy-efficient solution for future motion sensing systems.
{"title":"Robust Memcapacitive Synapse Array for Energy-Efficient Motion Detection","authors":"Jiazheng Chen, Arijit Sarkar, Md Sazzadur Rahman, Victoria Ravel, Aaron D. Franklin, Tania Roy","doi":"10.1021/acsnano.5c02340","DOIUrl":"https://doi.org/10.1021/acsnano.5c02340","url":null,"abstract":"Emerging neuromorphic systems offer a promising alternative for memory and sensing compared to traditional configurations, but face challenges with scalability and energy efficiency. Capacitive memories show great potential for addressing energy concerns due to their leakage-free nature. However, there is a lack of research on their scalability and robustness. In this work, we present a high-yield memcapacitor array that demonstrates reliable memory characteristics while also being capable of precisely sensing different types of vehicle motion with only a few picowatts of power consumption. Featuring a metal-oxide-semiconductor (MOS) structure with the most aggressively scaled dimensions compared to previously reported memcapacitors, we successfully established a 9 × 9 memcapacitor matrix with a yield of over 92.5%. The device exhibits tunable synaptic plasticity under varying pulsing schemes. We also demonstrate 64 distinct capacitance states and stable performance over 2 × 10<sup>4</sup> electrical pulses. Additionally, we showcase its application in motion sensing for autonomous vehicles, leveraging the short-term potentiation properties of the device. This approach offers a scalable, energy-efficient solution for future motion sensing systems.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"108 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143849664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ge Fang, Qingrong Dong, Xiaomei Shen, Rui Ye, Yuchen Chang, Kefeng Pu, Yujie Tao, Xingfa Gao, Ruhong Zhou, Cuicui Ge
Cuproptosis, an emerging cell death pathway, offers an alternative approach for antimicrobial therapy, but it suffers from deficiencies and health risks. Here, we design hollow Cu-enriched Prussian blue-based nanostructures (Cu-HMPBs) and find that the infected microenvironment facilitates the release of Cu ions from Cu-HMPBs, leading to Cu overload in bacterial cells. Meanwhile, Fe ions in bacterial cells are highly selectively chelated, triggering iron starvation. As a result, the proteotoxic stress and redox imbalance induced by Cu overload are aggravated upon iron starvation, thus remarkably enhancing cuproptosis-like bacterial cell death at extremely low-dose (noncytotoxic) Cu ions. Moreover, we demonstrate the effectiveness of this iron starvation-augmented antimicrobial strategy, and its efficacy is further validated in a methicillin-resistant Staphylococcus aureus (MRSA)-infected diabetic mouse wound model. Collectively, these findings provide a promising and universal strategy on iron starvation sensitizing cuproptosis-like bacterial cell death for combating drug resistance.
{"title":"Modulation of Bacterial Iron Homeostasis to Enhance Cuproptosis-like Death for the Treatment of Infected Diabetic Wound","authors":"Ge Fang, Qingrong Dong, Xiaomei Shen, Rui Ye, Yuchen Chang, Kefeng Pu, Yujie Tao, Xingfa Gao, Ruhong Zhou, Cuicui Ge","doi":"10.1021/acsnano.4c17071","DOIUrl":"https://doi.org/10.1021/acsnano.4c17071","url":null,"abstract":"Cuproptosis, an emerging cell death pathway, offers an alternative approach for antimicrobial therapy, but it suffers from deficiencies and health risks. Here, we design hollow Cu-enriched Prussian blue-based nanostructures (Cu-HMPBs) and find that the infected microenvironment facilitates the release of Cu ions from Cu-HMPBs, leading to Cu overload in bacterial cells. Meanwhile, Fe ions in bacterial cells are highly selectively chelated, triggering iron starvation. As a result, the proteotoxic stress and redox imbalance induced by Cu overload are aggravated upon iron starvation, thus remarkably enhancing cuproptosis-like bacterial cell death at extremely low-dose (noncytotoxic) Cu ions. Moreover, we demonstrate the effectiveness of this iron starvation-augmented antimicrobial strategy, and its efficacy is further validated in a methicillin-resistant <i>Staphylococcus aureus</i> (MRSA)-infected diabetic mouse wound model. Collectively, these findings provide a promising and universal strategy on iron starvation sensitizing cuproptosis-like bacterial cell death for combating drug resistance.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"28 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143849662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The extremely fast charging (XFC) of Li-ion cells is an urgent milestone in promoting the widespread adoption of electric vehicles. However, EV-targeted cell designs with thicker electrodes compromise the XFC capability when conventional electrolytes are used, leading to hazardous Li plating and a considerable loss in Li inventory. This study presents noncarbonate solvents for superionic conductive, low-viscosity high-concentration electrolytes (HCEs). A methyl acetate (MA)-based HCE with a solid–electrolyte interphase (SEI)-stabilizing additive (3MF) was comparatively examined using a dimethyl carbonate (DMC) solvent, which has an extra oxygen atom in the molecule, across all aspects, including solvation structures, interfacial kinetics, and bulk Li+ transport. The 3MF electrolyte demonstrated outstanding XFC performance in a pouch cell (1.2 Ah) format and outperformed DMC-based HCE, showcasing improved cycling performance at low temperatures (−20 °C), 10 C-rate (6-min charging), and with a thick electrode (6.0 mAh cm–2). By satisfying the energy barrier thresholds for Li+ desolvation and Li+ migration across the SEI, MA can guide smaller solvation clusters and serve as a molecular lubricant along the Li+ percolation pathway in the HCE framework, which is crucial for boosting XFC capabilities.
{"title":"Ester-Guided Dynamic Li+ Solvation Enables Plating-Less, Fast-Charging Li-Ion Batteries","authors":"Soyeon Lee, Hyuntae Lee, Hongjun Chang, Minhong Lim, Mingyu Lee, Bonhyeop Koo, Ko-Eun Ryou, Seong-Min Bak, Hochun Lee, Sujong Chae, Janghyuk Moon, Hongkyung Lee","doi":"10.1021/acsnano.5c00027","DOIUrl":"https://doi.org/10.1021/acsnano.5c00027","url":null,"abstract":"The extremely fast charging (XFC) of Li-ion cells is an urgent milestone in promoting the widespread adoption of electric vehicles. However, EV-targeted cell designs with thicker electrodes compromise the XFC capability when conventional electrolytes are used, leading to hazardous Li plating and a considerable loss in Li inventory. This study presents noncarbonate solvents for superionic conductive, low-viscosity high-concentration electrolytes (HCEs). A methyl acetate (MA)-based HCE with a solid–electrolyte interphase (SEI)-stabilizing additive (3MF) was comparatively examined using a dimethyl carbonate (DMC) solvent, which has an extra oxygen atom in the molecule, across all aspects, including solvation structures, interfacial kinetics, and bulk Li<sup>+</sup> transport. The 3MF electrolyte demonstrated outstanding XFC performance in a pouch cell (1.2 Ah) format and outperformed DMC-based HCE, showcasing improved cycling performance at low temperatures (−20 °C), 10 C-rate (6-min charging), and with a thick electrode (6.0 mAh cm<sup>–2</sup>). By satisfying the energy barrier thresholds for Li<sup>+</sup> desolvation and Li<sup>+</sup> migration across the SEI, MA can guide smaller solvation clusters and serve as a molecular lubricant along the Li<sup>+</sup> percolation pathway in the HCE framework, which is crucial for boosting XFC capabilities.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"11 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143849668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wenjuan Zeng, Yong Zhang, Xinyuan Wang, Shisheng Wang, Tianhai Lin, Tao Su, Youmei Jin, Yujia Yuan, Mengqi Luo, Yi Zhong, Li Li, Dingkun Zhang, Meng Gong, Jingqiu Cheng, Jingping Liu, Shan Liu, Weiya Wang, Lu Yang, Hao Yang
The serum prostate-specific antigen (PSA) testing is widely used for prostate cancer (PCa) screening but suffers from poor specificity, leading to unnecessary biopsies and overtreatment. The significant potential of extracellular vesicles (EVs) in cancer diagnosis has driven the development of efficient methods to isolate and identify EV biomarkers from large-scale clinical samples. Here, we systematically evaluate five commonly used EV isolation techniques through proteomic profiling of plasma-derived EVs, endorsing TiO2-based chemical affinity capture as a superior approach for analyzing EVs from complex clinical samples. This method demonstrates exceptional advantages in speed, throughput, reproducibility, and protein coverage. Using this optimized workflow, we analyzed plasma EVs from 80 patients with PCa and benign prostatic hyperplasia (BPH), identifying growth differentiation factor 15 (GDF15) as a compelling biomarker with a predictive power (AUC) of 0.908 for PCa. Extensive validation across independent cohorts comprising 457 samples, including plasma EVs and prostate tissues, confirmed GDF15’s ability to distinguish PCa from BPH and stratify PCa stages. Notably, the combination of GDF15 with PSA further enhanced diagnostic efficiency, particularly for patients in the PSA diagnostic gray zone. This study establishes a robust workflow for EV protein analysis in large clinical cohorts and highlights EV-GDF15 as a promising biomarker for noninvasive PCa diagnosis.
{"title":"Chemical Affinity Capture of Plasma Extracellular Vesicles Enables Efficient and Large-Scale Proteomic Identification of Prostate Cancer Biomarkers","authors":"Wenjuan Zeng, Yong Zhang, Xinyuan Wang, Shisheng Wang, Tianhai Lin, Tao Su, Youmei Jin, Yujia Yuan, Mengqi Luo, Yi Zhong, Li Li, Dingkun Zhang, Meng Gong, Jingqiu Cheng, Jingping Liu, Shan Liu, Weiya Wang, Lu Yang, Hao Yang","doi":"10.1021/acsnano.5c01564","DOIUrl":"https://doi.org/10.1021/acsnano.5c01564","url":null,"abstract":"The serum prostate-specific antigen (PSA) testing is widely used for prostate cancer (PCa) screening but suffers from poor specificity, leading to unnecessary biopsies and overtreatment. The significant potential of extracellular vesicles (EVs) in cancer diagnosis has driven the development of efficient methods to isolate and identify EV biomarkers from large-scale clinical samples. Here, we systematically evaluate five commonly used EV isolation techniques through proteomic profiling of plasma-derived EVs, endorsing TiO<sub>2</sub>-based chemical affinity capture as a superior approach for analyzing EVs from complex clinical samples. This method demonstrates exceptional advantages in speed, throughput, reproducibility, and protein coverage. Using this optimized workflow, we analyzed plasma EVs from 80 patients with PCa and benign prostatic hyperplasia (BPH), identifying growth differentiation factor 15 (GDF15) as a compelling biomarker with a predictive power (AUC) of 0.908 for PCa. Extensive validation across independent cohorts comprising 457 samples, including plasma EVs and prostate tissues, confirmed GDF15’s ability to distinguish PCa from BPH and stratify PCa stages. Notably, the combination of GDF15 with PSA further enhanced diagnostic efficiency, particularly for patients in the PSA diagnostic gray zone. This study establishes a robust workflow for EV protein analysis in large clinical cohorts and highlights EV-GDF15 as a promising biomarker for noninvasive PCa diagnosis.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"30 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nanomedicines offer a means to overcome the limitations associated with traditional drug dosage formulations by affording drug protection, enhanced drug bioavailability, and targeted drug delivery to affected sites. Inflamed tissues possess unique microenvironmental characteristics (including excessive reactive oxygen species, low pH levels, and hypoxia) that stimuli-responsive nanoparticles can employ as triggers to support on-demand delivery, enhanced accumulation, controlled release, and activation of anti-inflammatory drugs. Stimuli-responsive nanomedicines respond to physicochemical and pathological factors associated with diseased tissues to improve the specificity of drug delivery, overcome multidrug resistance, ensure accurate diagnosis and precision therapy, and control drug release to improve efficacy and safety. Current stimuli-responsive nanoparticles react to intracellular/microenvironmental stimuli such as pH, redox, hypoxia, or specific enzymes and exogenous stimuli such as temperature, magnetic fields, light, and ultrasound via bioresponsive moieties. This review summarizes the general strategies employed to produce stimuli-responsive nanoparticles tailored for inflammatory diseases and all recent advances, reports their applications in drug delivery, and illustrates the progress made toward clinical translation.
{"title":"Stimuli-Responsive Nanomedicines for the Treatment of Non-cancer Related Inflammatory Diseases","authors":"Jingjing Yang, Anne des Rieux, Alessio Malfanti","doi":"10.1021/acsnano.5c00700","DOIUrl":"https://doi.org/10.1021/acsnano.5c00700","url":null,"abstract":"Nanomedicines offer a means to overcome the limitations associated with traditional drug dosage formulations by affording drug protection, enhanced drug bioavailability, and targeted drug delivery to affected sites. Inflamed tissues possess unique microenvironmental characteristics (including excessive reactive oxygen species, low pH levels, and hypoxia) that stimuli-responsive nanoparticles can employ as triggers to support on-demand delivery, enhanced accumulation, controlled release, and activation of anti-inflammatory drugs. Stimuli-responsive nanomedicines respond to physicochemical and pathological factors associated with diseased tissues to improve the specificity of drug delivery, overcome multidrug resistance, ensure accurate diagnosis and precision therapy, and control drug release to improve efficacy and safety. Current stimuli-responsive nanoparticles react to intracellular/microenvironmental stimuli such as pH, redox, hypoxia, or specific enzymes and exogenous stimuli such as temperature, magnetic fields, light, and ultrasound via bioresponsive moieties. This review summarizes the general strategies employed to produce stimuli-responsive nanoparticles tailored for inflammatory diseases and all recent advances, reports their applications in drug delivery, and illustrates the progress made toward clinical translation.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"9 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zongyang Ya, Mei Li, Dong Xu, Hua Wang, Shengbo Zhang
Waste plastic has imposed significant burdens on marine ecosystems. Converting plastic into high-value products via photocatalysis is an emerging and promising approach, but its low activity and product selectivity pose great challenges. Herein, we report a carbon nitride-anchored atomically dispersed Pt–B dual-site catalyst (Pt SA/BCN100) for the photoreforming of polylactic acid (PLA) into high-value chemicals and H2 in seawater. Experiments and DFT calculations reveal that significantly enhanced charge transfer occurs between the Pt site and the B site, and the hole-rich B site can selectively trigger the activation and cleavage of the C–H and C–C bonds of PLA to form acetic acid (AA), while the electron-rich Pt site drives the reduction of H protons to H2. As a result, Pt SA/BCN100 exhibits a high H2 evolution rate of 993 μmol gcatal–1 h–1 and an AA production rate of 300 μmol gcatal–1 h–1 with a selectivity of over 98%. We also demonstrate the direct photoreforming of g-scale real-world PLA wastes and low concentrations of PLA microplastics in natural seawater. Techno-economic analysis and environmental assessment show that this catalytic system can significantly reduce carbon emissions and has potential commercial value.
{"title":"Asymmetric Atomic Pt–B Dual-Site Catalyst for Efficient Photoreforming of Waste Polylactic Acid Plastics in Seawater","authors":"Zongyang Ya, Mei Li, Dong Xu, Hua Wang, Shengbo Zhang","doi":"10.1021/acsnano.5c02408","DOIUrl":"https://doi.org/10.1021/acsnano.5c02408","url":null,"abstract":"Waste plastic has imposed significant burdens on marine ecosystems. Converting plastic into high-value products via photocatalysis is an emerging and promising approach, but its low activity and product selectivity pose great challenges. Herein, we report a carbon nitride-anchored atomically dispersed Pt–B dual-site catalyst (Pt SA/BCN100) for the photoreforming of polylactic acid (PLA) into high-value chemicals and H<sub>2</sub> in seawater. Experiments and DFT calculations reveal that significantly enhanced charge transfer occurs between the Pt site and the B site, and the hole-rich B site can selectively trigger the activation and cleavage of the C–H and C–C bonds of PLA to form acetic acid (AA), while the electron-rich Pt site drives the reduction of H protons to H<sub>2</sub>. As a result, Pt SA/BCN100 exhibits a high H<sub>2</sub> evolution rate of 993 μmol g<sub>catal</sub><sup>–1</sup> h<sup>–1</sup> and an AA production rate of 300 μmol g<sub>catal</sub><sup>–1</sup> h<sup>–1</sup> with a selectivity of over 98%. We also demonstrate the direct photoreforming of g-scale real-world PLA wastes and low concentrations of PLA microplastics in natural seawater. Techno-economic analysis and environmental assessment show that this catalytic system can significantly reduce carbon emissions and has potential commercial value.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"47 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Benjamin Pestka, Jeff Strasdas, Gustav Bihlmayer, Adam Krzysztof Budniak, Marcus Liebmann, Niklas Leuth, Honey Boban, Vitaliy Feyer, Iulia Cojocariu, Daniel Baranowski, Simone Mearini, Yaron Amouyal, Lutz Waldecker, Bernd Beschoten, Christoph Stampfer, Lukasz Plucinski, Efrat Lifshitz, Peter Kratzer, Markus Morgenstern
Error 1: On page 3, in the Results and Discussion, line 28, it states “Ueff = U – J = 12 eV”. This should read “Ueff = U – J = 1.2 eV”. Error 2: On page 4, line 17, it states “flat Fe 3d band at E – EF ≈ eV”. This should read “flat Fe 3d band at E – EF ≈ –4.8 eV”. This erratum does not affect any of the experimental results, discussions, or conclusions reported in the original publication. This article has not yet been cited by other publications.
{"title":"Correction to “Identifying Band Structure Changes of FePS3 across the Antiferromagnetic Phase Transition”","authors":"Benjamin Pestka, Jeff Strasdas, Gustav Bihlmayer, Adam Krzysztof Budniak, Marcus Liebmann, Niklas Leuth, Honey Boban, Vitaliy Feyer, Iulia Cojocariu, Daniel Baranowski, Simone Mearini, Yaron Amouyal, Lutz Waldecker, Bernd Beschoten, Christoph Stampfer, Lukasz Plucinski, Efrat Lifshitz, Peter Kratzer, Markus Morgenstern","doi":"10.1021/acsnano.5c04070","DOIUrl":"https://doi.org/10.1021/acsnano.5c04070","url":null,"abstract":"Error 1: On page 3, in the Results and Discussion, line 28, it states “<i>U</i><sub>eff</sub> = <i>U</i> – <i>J</i> = 12 eV”. This should read “<i>U</i><sub>eff</sub> = <i>U</i> – <i>J</i> = 1.2 eV”. Error 2: On page 4, line 17, it states “flat Fe 3d band at <i>E</i> – <i>E</i><sub>F</sub> ≈ eV”. This should read “flat Fe 3d band at <i>E</i> – <i>E</i><sub>F</sub> ≈ –4.8 eV”. This erratum does not affect any of the experimental results, discussions, or conclusions reported in the original publication. This article has not yet been cited by other publications.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"10 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ischemic stroke (IS) as a detrimental neurological disease is accompanied by oxidative-stress-induced injury, concurrent inflammatory response, overactivated brain immune microenvironment, and disruption of the blood–brain barrier (BBB). This cascade of events ultimately leads to neuronal death and significantly impairs the recovery of neurological function. In this study, we presented extracellular vesicles derived from the gut probiotic Lactobacillus reuteri (LrEVs) integrated with brain targeting, reactive oxygen species (ROS) scavenging, and reduced infiltration of immune cells for effective multiple therapeutic interventions of IS. LrEVs inherited peptidoglycan (PGN) specifically targeted upregulated toll-like receptor 2 (TLR2) in the injured region of the ischemic brain, achieving the effective penetration of the BBB and accumulation in the ischemic brain. In the meantime, LrEVs prevented neuronal apoptosis after stroke by scavenging ROS overproduction and modulating microglial polarization through inhibition of the MAPK and NF-κB pathways. Furthermore, LrEVs inhibited the aggregation of C–C motif chemokine ligand 2 (CCL2), reduced the infiltration of peripheral immune cells such as macrophages and neutrophils into ischemic brain tissue, and suppressed the impairment of BBB, thereby improving the overactivated brain immune microenvironment. The findings provide a vesicle that combines ROS scavenging and modulation of the immune microenvironment, showcasing the potential of gut-probiotic-derived vesicles to treat neurological damage.
{"title":"Brain Targeting Bacterial Extracellular Vesicles Enhance Ischemic Stroke Therapy via Efficient ROS Elimination and Suppression of Immune Infiltration","authors":"Mengdi Sun, Jinghan Ma, Ge Zhang, Mingzhu Song, Ruizhen Lv, Jia Liang, Yijie Shi, Liang Zhao","doi":"10.1021/acsnano.4c16161","DOIUrl":"https://doi.org/10.1021/acsnano.4c16161","url":null,"abstract":"Ischemic stroke (IS) as a detrimental neurological disease is accompanied by oxidative-stress-induced injury, concurrent inflammatory response, overactivated brain immune microenvironment, and disruption of the blood–brain barrier (BBB). This cascade of events ultimately leads to neuronal death and significantly impairs the recovery of neurological function. In this study, we presented extracellular vesicles derived from the gut probiotic <i>Lactobacillus reuteri</i> (LrEVs) integrated with brain targeting, reactive oxygen species (ROS) scavenging, and reduced infiltration of immune cells for effective multiple therapeutic interventions of IS. LrEVs inherited peptidoglycan (PGN) specifically targeted upregulated toll-like receptor 2 (TLR2) in the injured region of the ischemic brain, achieving the effective penetration of the BBB and accumulation in the ischemic brain. In the meantime, LrEVs prevented neuronal apoptosis after stroke by scavenging ROS overproduction and modulating microglial polarization through inhibition of the MAPK and NF-κB pathways. Furthermore, LrEVs inhibited the aggregation of C–C motif chemokine ligand 2 (CCL2), reduced the infiltration of peripheral immune cells such as macrophages and neutrophils into ischemic brain tissue, and suppressed the impairment of BBB, thereby improving the overactivated brain immune microenvironment. The findings provide a vesicle that combines ROS scavenging and modulation of the immune microenvironment, showcasing the potential of gut-probiotic-derived vesicles to treat neurological damage.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"10 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143849667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Goro Nishide, Tomoka Ishibashi, Keesiang Lim, Yujia Qiu, Masaharu Hazawa, Ayami Matsushima, Richard W. Wong
Estrogen receptor α (ERα) is pivotal in gene regulation, particularly in estrogen-responsive cancers. However, the full-length molecular dynamic structure of ERα remains elusive. In this study, we employ high-speed atomic force microscopy (HS-AFM) to visualize ERα interactions with the estrogen response element (ERE) under both ligand-present and ligand-absent conditions. ERα binds to ERE even in the absence of estrogen, although the presence of the ligand significantly enhances binding precision and stability. Our real-time, high-resolution HS-AFM imaging captures ERα structural transitions from monomeric to dimeric forms, elucidating the molecular mechanisms by which estrogen modulates DNA-binding specificity. Based on these findings, we propose a ligand-induced dimerization (LID) model, wherein estrogen facilitates the optimal loading of ERα onto DNA. These insights deepen our understanding of hormone signaling in cancer and hold promise for the development of future therapeutic strategies targeting hormone-related malignancies.
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