Hongwei Wang,Gan Jin,Mingyang Du,Yuxin Li,Xu Li,Xudong Zhu,Yurong Yang,Baomin Wang,Xiaohui Liu,Chengwang Niu,Lixin He,Tian Cui,Karin M. Rabe,Feng Liu
Rashba-type spin–orbit coupling is an important physical phenomenon for spintronic device applications. The size of Rashba splitting is generally enhanced by increasing inversion symmetry breaking, typically by increasing the spontaneous polarization of ferroelectric materials. Here, we identify an intriguing mechanism to enhance Rashba splitting by topological band inversion induced by strain. Using density functional theory, we show that monolayer quasi-1D ferroelectric chalcogenides BaTiSe3 and BaZrSe3 exhibit in-plane polarization, giving rise to Rashba splitting in the valence and conduction band edges with a persistent spin texture. Remarkably, under 1% compressive biaxial strain, the Rashba parameter and splitting energy of monolayer BaZrSe3 are enhanced to ∼3.0 eV Å and ∼60 meV, respectively, among the highest in 2D materials, and concurrently, a giant Berry curvature is induced, which is ∼1400 Å2 in magnitude. Our analysis shows that these enhancements result from a generic mechanism of strain-induced phase transition from semiconductor to topological insulator, which in turn changes interband transitions. Our findings manifest a unique strain-induced interplay between topology and ferroelectricity, and the integration of topological bands with Rashba splitting may provide promising applications to advancing spintronics technology.
rashba型自旋轨道耦合是自旋电子器件应用中的重要物理现象。Rashba分裂的大小通常通过增加反转对称性破缺来增强，特别是通过增加铁电材料的自发极化来增强。在这里，我们确定了一个有趣的机制，以增强Rashba分裂由应变引起的拓扑能带反转。利用密度泛函理论，我们发现单层准一维铁电硫族化合物BaTiSe3和BaZrSe3表现出面内极化，在价带和导带边缘产生Rashba分裂，并具有持续的自旋织体。值得注意的是，在1%的双轴压缩应变下，单层BaZrSe3的Rashba参数和分裂能分别提高到~ 3.0 eV Å和~ 60 meV，是二维材料中最高的，同时产生了一个巨大的Berry曲率，其量级为~ 1400 Å2。我们的分析表明，这些增强来自于从半导体到拓扑绝缘体的应变诱导相变的一般机制，这反过来又改变了带间转变。我们的发现表明了一种独特的应变诱导的拓扑和铁电性之间的相互作用，并且拓扑带与Rashba分裂的集成可能为推进自旋电子学技术提供有前途的应用。
{"title":"Strain-Induced Giant Topological Rashba Splitting","authors":"Hongwei Wang,Gan Jin,Mingyang Du,Yuxin Li,Xu Li,Xudong Zhu,Yurong Yang,Baomin Wang,Xiaohui Liu,Chengwang Niu,Lixin He,Tian Cui,Karin M. Rabe,Feng Liu","doi":"10.1021/acsnano.5c16503","DOIUrl":"https://doi.org/10.1021/acsnano.5c16503","url":null,"abstract":"Rashba-type spin–orbit coupling is an important physical phenomenon for spintronic device applications. The size of Rashba splitting is generally enhanced by increasing inversion symmetry breaking, typically by increasing the spontaneous polarization of ferroelectric materials. Here, we identify an intriguing mechanism to enhance Rashba splitting by topological band inversion induced by strain. Using density functional theory, we show that monolayer quasi-1D ferroelectric chalcogenides BaTiSe3 and BaZrSe3 exhibit in-plane polarization, giving rise to Rashba splitting in the valence and conduction band edges with a persistent spin texture. Remarkably, under 1% compressive biaxial strain, the Rashba parameter and splitting energy of monolayer BaZrSe3 are enhanced to ∼3.0 eV Å and ∼60 meV, respectively, among the highest in 2D materials, and concurrently, a giant Berry curvature is induced, which is ∼1400 Å2 in magnitude. Our analysis shows that these enhancements result from a generic mechanism of strain-induced phase transition from semiconductor to topological insulator, which in turn changes interband transitions. Our findings manifest a unique strain-induced interplay between topology and ferroelectricity, and the integration of topological bands with Rashba splitting may provide promising applications to advancing spintronics technology.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"66 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146111149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bioinspired nanofluidic systems that utilize ions as signal carriers hold great promise for emulating neural processing in biochemical sensing and neuromorphic computing. However, achieving parallel, brain-like processing of multiple biochemical signals remains a significant challenge. Herein, we present a nanofluidic artificial postsynaptic membrane (APM) functionalized with confined DNA aptamers to construct a neuromorphic signal processing platform. Target-induced conformational switching of DNA aptamers dynamically modulates ionic transport through nanochannels, effectively mimicking synaptic information transmission. The integration of cross-responsive aptamer-based APM units into a cascaded logic system enables signal processing without relying on the physical series network of nanochannels. By independently addressing and reading each unit, dendritic multi-input integration and brain-like information fusion are achieved at the signal-algorithm level, and 100% accurate discrimination of multiple targets is reached. This approach marks a conceptual shift from the traditional “one-probe-one-target” model toward a brain-inspired, multitarget recognition architecture. The fusion of DNA probes with nanofluidic logic and their cascade at the signal level enables the development of neuromorphic biochips with integrated processing capabilities for multiplexed signals.
{"title":"Nanofluidic Confined DNA Aptamers for Neuromorphic Multiplex Discrimination","authors":"Yonghuan Chen,Xinru Yue,Yixin Ling,Yang Liu,Weihua Yu,Qi Zhu,Zilong He,Minrui Long,Xin-Qi Hao,Xu Hou,Fengyu Li","doi":"10.1021/acsnano.5c16862","DOIUrl":"https://doi.org/10.1021/acsnano.5c16862","url":null,"abstract":"Bioinspired nanofluidic systems that utilize ions as signal carriers hold great promise for emulating neural processing in biochemical sensing and neuromorphic computing. However, achieving parallel, brain-like processing of multiple biochemical signals remains a significant challenge. Herein, we present a nanofluidic artificial postsynaptic membrane (APM) functionalized with confined DNA aptamers to construct a neuromorphic signal processing platform. Target-induced conformational switching of DNA aptamers dynamically modulates ionic transport through nanochannels, effectively mimicking synaptic information transmission. The integration of cross-responsive aptamer-based APM units into a cascaded logic system enables signal processing without relying on the physical series network of nanochannels. By independently addressing and reading each unit, dendritic multi-input integration and brain-like information fusion are achieved at the signal-algorithm level, and 100% accurate discrimination of multiple targets is reached. This approach marks a conceptual shift from the traditional “one-probe-one-target” model toward a brain-inspired, multitarget recognition architecture. The fusion of DNA probes with nanofluidic logic and their cascade at the signal level enables the development of neuromorphic biochips with integrated processing capabilities for multiplexed signals.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"61 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146111147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Electrochemical carbon–nitrogen (C–N) coupling using simple inorganic feedstocks offers a sustainable route to valuable organonitrogen compounds such as amino acids. Herein, we present an atomically thin and acid-resistant p-block bismuthene (Bi-ene) derived via the reconstruction of a Bi-based metal–organic framework, where the enriched atomic misarrangement induces significant lattice strain that modulates the local electronic structure of the resultant Bi-ene, significantly boosting its electrocatalytic activity. Such defective Bi-ene exhibits an exceptional electrocatalytic performance for reductive C–N coupling in a salt-free acidic system, achieving a Faradaic efficiency (FE) of 95.7% and an ultrahigh yield rate of 1161 μmol cm–2 h–1 for NH2OH generation via the nitrate reduction reaction (NtrRR). Further, the efficient coreduction of HNO3 and oxalic acid (OA) over Bi-ene simultaneously generates NH2OH and glyoxylic acid (GX) respectively, which undergo effective C–N coupling to produce glycine with a high yield of 455.4 μmol cm–2 h–1. Moreover, the Bi-ene demonstrates stable performance for over 120 h at an industrial-relevant current density of 200 mA cm–2. Operando spectroscopy and calculations reveal that the strain in lattice-distorted Bi-ene optimizes the intermediate adsorption through modulating local electronic structure and thus enhances the efficacy for glycine electrosynthesis.
电化学碳氮（C-N）偶联使用简单的无机原料提供了一个可持续的途径有价值的有机氮化合物，如氨基酸。在此，我们提出了一种原子薄且耐酸的p-嵌段铋（Bi-ene），通过重建bi基金属有机框架，其中富集的原子错排引起显著的晶格应变，从而调节所得Bi-ene的局部电子结构，显著提高其电催化活性。该缺陷双烯在无盐酸性体系中对还原性C-N偶联具有优异的电催化性能，通过硝酸盐还原反应（NtrRR）生成NH2OH的法拉第效率（FE）达到95.7%，产率高达1161 μmol cm-2 h-1。此外，HNO3和草酸（OA）在双烯上有效共还原，分别生成NH2OH和乙醛酸（GX），并通过有效的C-N偶联生成甘氨酸，产率高达455.4 μmol cm-2 h-1。此外，在工业相关的200 mA cm-2电流密度下，Bi-ene表现出超过120小时的稳定性能。Operando光谱和计算结果表明，晶格畸变双烯中的应变通过调节局部电子结构来优化中间吸附，从而提高了甘氨酸电合成的效率。
{"title":"Salt-Free Glycine Electrosynthesis via Carbon–Nitrogen Coupling Boosted by the Lattice Strain in Atomically Thin p-Block Bismuthene","authors":"Minghong Huang,Sheng-Hua Zhou,Cheng-Jie Yang,Chung-Li Dong,Lei Jiao,Dong-Dong Ma,Qi-Long Zhu,Zhenguo Huang","doi":"10.1021/acsnano.5c19472","DOIUrl":"https://doi.org/10.1021/acsnano.5c19472","url":null,"abstract":"Electrochemical carbon–nitrogen (C–N) coupling using simple inorganic feedstocks offers a sustainable route to valuable organonitrogen compounds such as amino acids. Herein, we present an atomically thin and acid-resistant p-block bismuthene (Bi-ene) derived via the reconstruction of a Bi-based metal–organic framework, where the enriched atomic misarrangement induces significant lattice strain that modulates the local electronic structure of the resultant Bi-ene, significantly boosting its electrocatalytic activity. Such defective Bi-ene exhibits an exceptional electrocatalytic performance for reductive C–N coupling in a salt-free acidic system, achieving a Faradaic efficiency (FE) of 95.7% and an ultrahigh yield rate of 1161 μmol cm–2 h–1 for NH2OH generation via the nitrate reduction reaction (NtrRR). Further, the efficient coreduction of HNO3 and oxalic acid (OA) over Bi-ene simultaneously generates NH2OH and glyoxylic acid (GX) respectively, which undergo effective C–N coupling to produce glycine with a high yield of 455.4 μmol cm–2 h–1. Moreover, the Bi-ene demonstrates stable performance for over 120 h at an industrial-relevant current density of 200 mA cm–2. Operando spectroscopy and calculations reveal that the strain in lattice-distorted Bi-ene optimizes the intermediate adsorption through modulating local electronic structure and thus enhances the efficacy for glycine electrosynthesis.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"105 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146111143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Transitional metals (TMs)-based high-entropy alloys (HEAs) have demonstrated exceptional oxygen evolution reaction (OER) activity due to tunable electronic configurations and multimetallic synergy. However, their stability is hindered by oxidation and structural degradation resulting from intermetallic electron interactions during operation. Herein, we propose a cerium-mediated charge redistribution strategy in FeCoNiMnCe HEA, facilitating charge transfer from electron-rich Ce to neighboring TMs. This Ce-introduced HEA features increased dissolving activation energy of Fe/Mn and optimized electronic orbitals of Co/Ni, which inhibits the deactivation of active sites induced by high oxidized states during OER. Benefiting from charge accumulation on TMs, FeCoNiMnCe HEA achieves outstanding durability with negligible decay over 1000 h for OER at 10 mA cm–2 and enables stable zinc-air batteries operation for 4600 h at 2 mA cm–2. This work provides a robust strategy for designing stable HEA electrocatalysts through targeted electronic modulation.
基于过渡金属（TMs）的高熵合金（HEAs）由于可调谐的电子构型和多金属协同作用而表现出优异的析氧反应（OER）活性。然而，在操作过程中，金属间电子相互作用导致的氧化和结构降解阻碍了它们的稳定性。在此，我们提出了在FeCoNiMnCe HEA中铈介导的电荷再分配策略，促进电荷从富电子Ce转移到邻近的TMs。引入ce的HEA提高了Fe/Mn的溶解活化能，优化了Co/Ni的电子轨道，抑制了OER过程中高氧化态引起的活性位点失活。得益于TMs上的电荷积累，FeCoNiMnCe HEA在10 mA cm-2下的OER超过1000小时的衰减可以忽略不计，并且可以使锌-空气电池在2 mA cm-2下稳定运行4600小时。这项工作为通过定向电子调制设计稳定的HEA电催化剂提供了强有力的策略。
{"title":"Rare-Earth Element-Induced Charge Redistribution in High-Entropy Alloys toward Highly Stable Oxygen Evolution Catalysis","authors":"Junjie Hu,Zhitong Li,Xia Lei,Yanyi Wang,Wenbo Peng,Shuyu Cui,Kelin Chen,Gaole Liu,Tian Lang,Peide Zhu,Xiaolong Zhou,Sarayut Tunmee,Jintara Padchasri,Suttipong Wannapaiboon,Xingzhu Wang,Lei Yan,Xiongwei Zhong,Baomin Xu","doi":"10.1021/acsnano.5c18246","DOIUrl":"https://doi.org/10.1021/acsnano.5c18246","url":null,"abstract":"Transitional metals (TMs)-based high-entropy alloys (HEAs) have demonstrated exceptional oxygen evolution reaction (OER) activity due to tunable electronic configurations and multimetallic synergy. However, their stability is hindered by oxidation and structural degradation resulting from intermetallic electron interactions during operation. Herein, we propose a cerium-mediated charge redistribution strategy in FeCoNiMnCe HEA, facilitating charge transfer from electron-rich Ce to neighboring TMs. This Ce-introduced HEA features increased dissolving activation energy of Fe/Mn and optimized electronic orbitals of Co/Ni, which inhibits the deactivation of active sites induced by high oxidized states during OER. Benefiting from charge accumulation on TMs, FeCoNiMnCe HEA achieves outstanding durability with negligible decay over 1000 h for OER at 10 mA cm–2 and enables stable zinc-air batteries operation for 4600 h at 2 mA cm–2. This work provides a robust strategy for designing stable HEA electrocatalysts through targeted electronic modulation.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"11 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146111146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lateral semiconductor homojunctions offer the advantages of perfect lattice matching and efficient carrier transport at the junctions, providing an ideal platform for high-performance optoelectronic devices. However, the fabrication of high-quality homostructures and the simultaneous realization of strong photovoltaic and photodetection performance remain challenging. In this work, we directly fabricated n+–n– MoS2 homostructures, consisting of partly pristine MoS2 and partly MoS2 stacked on a CrOCl insulator. Efficient charge transfer occurs at the MoS2/CrOCl interface, as confirmed by a ∼200 meV band shift observed in micro-ARPES measurements, consistent with our DFT calculations. As a result, the portion of MoS2 stacked on CrOCl can be modulated to p-type by controlling the gate voltage, in sharp contrast to the pristine MoS2 region. Moreover, the n+–n– MoS2 homostructures exhibit an open-circuit voltage of 0.87 V, a detectivity exceeding 1012 Jones, and a responsivity of 0.98 A/W without external stimuli, demonstrating both ultrahigh photovoltaic and self-powered photodetection capabilities. The results presented in our work provide a strategy for developing efficient optoelectronic devices based on two-dimensional homostructures.
横向半导体同质结具有完美的晶格匹配和高效的载流子输运等优点，为高性能光电器件提供了理想的平台。然而，制造高质量的同质结构并同时实现强大的光伏和光探测性能仍然具有挑战性。在这项工作中，我们直接制作了n+ - n - MoS2同质结构，由部分原始MoS2和部分堆叠在CrOCl绝缘体上的MoS2组成。有效的电荷转移发生在MoS2/CrOCl界面，正如在微arpes测量中观察到的~ 200 meV带移所证实的那样，与我们的DFT计算一致。因此，通过控制栅极电压，可以将堆叠在CrOCl上的MoS2部分调制为p型，与原始MoS2区域形成鲜明对比。此外，n+ - n- MoS2同构结构的开路电压为0.87 V，探测率超过1012 Jones，响应率为0.98 a /W，在没有外部刺激的情况下，显示出超高的光伏和自供电光探测能力。我们的工作结果为开发基于二维同构结构的高效光电器件提供了一种策略。
{"title":"Giant Photovoltaic Effect and Self-Powered Photodetection in Lateral MoS2 Homojunctions via Strong Interface Coupling","authors":"Jiyuan Xu,Yinglun Sun,Gangqiang Zhou,Jiajun Fang,Alexei Barinov,Nitin Mallik,Azzedine Bendounan,Marino Marsi,Zailan Zhang,Yingchun Cheng,Zhesheng Chen","doi":"10.1021/acsnano.5c18507","DOIUrl":"https://doi.org/10.1021/acsnano.5c18507","url":null,"abstract":"Lateral semiconductor homojunctions offer the advantages of perfect lattice matching and efficient carrier transport at the junctions, providing an ideal platform for high-performance optoelectronic devices. However, the fabrication of high-quality homostructures and the simultaneous realization of strong photovoltaic and photodetection performance remain challenging. In this work, we directly fabricated n+–n– MoS2 homostructures, consisting of partly pristine MoS2 and partly MoS2 stacked on a CrOCl insulator. Efficient charge transfer occurs at the MoS2/CrOCl interface, as confirmed by a ∼200 meV band shift observed in micro-ARPES measurements, consistent with our DFT calculations. As a result, the portion of MoS2 stacked on CrOCl can be modulated to p-type by controlling the gate voltage, in sharp contrast to the pristine MoS2 region. Moreover, the n+–n– MoS2 homostructures exhibit an open-circuit voltage of 0.87 V, a detectivity exceeding 1012 Jones, and a responsivity of 0.98 A/W without external stimuli, demonstrating both ultrahigh photovoltaic and self-powered photodetection capabilities. The results presented in our work provide a strategy for developing efficient optoelectronic devices based on two-dimensional homostructures.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"17 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146111144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Osteosarcoma (OS) presents formidable challenges due to its aggressive progression and resistance to conventional therapies. Recent advancements in multimodal strategies, such as combining gene therapy with mild-temperature photothermal therapy (mPTT), referred to as GT-mPTT, have shown promise in enhancing therapeutic efficacy while minimizing side effects. However, current systems face limitations in therapeutic response, efficiency, and biosafety. Herein, we report a reactive oxygen species (ROS)-responsive polymeric amphiphile for imaging-guided combinational GT-mPTT therapy, achieving a high-efficiency antitumor performance against OS. This polymer incorporates guanidine-functionalized units for effective gene condensation and near-infrared II (NIR-II) active dyes for efficient photothermal conversion. The system exhibits charge reversal under elevated intratumoral ROS levels, promoting gene release, and achieves controlled mild hyperthermia under NIR-II irradiation, enhancing cellular uptake and enabling effective mPTT. The GT-mPTT combination therapy, guided by dual NIR-II fluorescence and photothermal imaging, demonstrated significant therapeutic outcomes in vitro and in vivo. These include pronounced tumor cell apoptosis, substantial tumor size reduction, and mitigation of osteolysis in OS-bearing mouse models, all while maintaining excellent biosafety and negligible systemic toxicity. This work shows the potential of responsive polymeric platforms with integrated multimodal therapeutic and imaging capabilities as a robust foundation for advancing precision therapies against OS.
{"title":"Charge-Reversal Near-Infrared II Polymeric Amphiphiles Enable Efficient Combinatorial Gene and Mild Photothermal Therapy for Osteosarcoma","authors":"Fang Tang,Xiaoyu Zhang,Zhenqi Liu,Aojie Liu,Hairui Liu,Shi Ding,Yajie Lu,Hua Bai,Aixiang Ding,Jing Li,Lin Li","doi":"10.1021/acsnano.5c10419","DOIUrl":"https://doi.org/10.1021/acsnano.5c10419","url":null,"abstract":"Osteosarcoma (OS) presents formidable challenges due to its aggressive progression and resistance to conventional therapies. Recent advancements in multimodal strategies, such as combining gene therapy with mild-temperature photothermal therapy (mPTT), referred to as GT-mPTT, have shown promise in enhancing therapeutic efficacy while minimizing side effects. However, current systems face limitations in therapeutic response, efficiency, and biosafety. Herein, we report a reactive oxygen species (ROS)-responsive polymeric amphiphile for imaging-guided combinational GT-mPTT therapy, achieving a high-efficiency antitumor performance against OS. This polymer incorporates guanidine-functionalized units for effective gene condensation and near-infrared II (NIR-II) active dyes for efficient photothermal conversion. The system exhibits charge reversal under elevated intratumoral ROS levels, promoting gene release, and achieves controlled mild hyperthermia under NIR-II irradiation, enhancing cellular uptake and enabling effective mPTT. The GT-mPTT combination therapy, guided by dual NIR-II fluorescence and photothermal imaging, demonstrated significant therapeutic outcomes in vitro and in vivo. These include pronounced tumor cell apoptosis, substantial tumor size reduction, and mitigation of osteolysis in OS-bearing mouse models, all while maintaining excellent biosafety and negligible systemic toxicity. This work shows the potential of responsive polymeric platforms with integrated multimodal therapeutic and imaging capabilities as a robust foundation for advancing precision therapies against OS.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"8 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146111152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acute liver failure (ALF) represents a life-threatening medical emergency with high mortality, yet limited treatment is available clinically. Here, we report albumin-biomineralized nonstoichiometric copper sulfide nanoparticles serving as first-aid nanomedicine to combat ALF, conceptualized as NanoAID. The NanoAID exhibits an electron-donor nanoantioxidant property to scavenge reactive oxygen species and concurrent anti-inflammatory capacity to reprogram pro-inflammatory M1 macrophages into anti-inflammatory M2-phenotype, thereby mitigating excessive oxidative and inflammatory stress in ALF lesions. More interestingly, we found Cu ions release under an in situ oxidative stress switch and the resulting H2S gas generation by NanoAID degradation, which further enhance the biosynthesis of intrahepatic antioxidant enzyme SOD1 and the repolarization of M1-to-M2 macrophages, respectively, thereby self-reinforcing ALF therapy. Such microenvironment self-adaptive regulation confers NanoAID with effective prophylactic efficacy and significant ALF survival advantages over the FDA-approved N-acetyl cysteine in multiple animal models, extending the first-aid window to 6 h post APAP intoxication. Transcriptomics results reveal the molecular mechanisms of NanoAID by promoting antioxidative and inhibiting inflammatory pathways, underscoring its great potential as a next-generation first-aid nanomedicine for ALF management.
{"title":"A First-Aid Nanomedicine Endowed with Microenvironment Self-Adaptive Regulation Ability to Facilitate Acute Liver Failure Prophylaxis and Therapy","authors":"Jiale Zhang,Mijia Yan,Yiwen Tang,Min Liu,Wenzhan Yao,Qiuhong Zhang,Hangrong Chen","doi":"10.1021/acsnano.5c18314","DOIUrl":"https://doi.org/10.1021/acsnano.5c18314","url":null,"abstract":"Acute liver failure (ALF) represents a life-threatening medical emergency with high mortality, yet limited treatment is available clinically. Here, we report albumin-biomineralized nonstoichiometric copper sulfide nanoparticles serving as first-aid nanomedicine to combat ALF, conceptualized as NanoAID. The NanoAID exhibits an electron-donor nanoantioxidant property to scavenge reactive oxygen species and concurrent anti-inflammatory capacity to reprogram pro-inflammatory M1 macrophages into anti-inflammatory M2-phenotype, thereby mitigating excessive oxidative and inflammatory stress in ALF lesions. More interestingly, we found Cu ions release under an in situ oxidative stress switch and the resulting H2S gas generation by NanoAID degradation, which further enhance the biosynthesis of intrahepatic antioxidant enzyme SOD1 and the repolarization of M1-to-M2 macrophages, respectively, thereby self-reinforcing ALF therapy. Such microenvironment self-adaptive regulation confers NanoAID with effective prophylactic efficacy and significant ALF survival advantages over the FDA-approved N-acetyl cysteine in multiple animal models, extending the first-aid window to 6 h post APAP intoxication. Transcriptomics results reveal the molecular mechanisms of NanoAID by promoting antioxidative and inhibiting inflammatory pathways, underscoring its great potential as a next-generation first-aid nanomedicine for ALF management.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"9 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146111145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Near-infrared II (NIR-II) imaging-guided photothermal therapy (PTT) represents a promising noninvasive strategy for treating bacterial infections. However, its efficacy is often limited by poor agent accumulation at infection sites and insufficient penetration into biofilms. Herein, we developed stiffness-tunable phenolic nanocapsules (NCs) loaded with NIR-II J-aggregates for enhanced biofilm phototherapy. Specifically, the NIR-II photothermal molecule of BTPTIC was synthesized and assembled with 8-arm-PEG-OH to form J-aggregates (BTPTIC@PEG J-aggregates). The BTPTIC@PEG J-aggregates were used as mineralizers to synthesize zeolitic imidazolate framework-8 (ZIF-8), followed by template etching with tannic acid (TA) to obtain J-aggregate-loaded phenolic NCs (BTPTIC@PEG-TA NCs). The resulting NCs not only display strong NIR-II fluorescence and a high photothermal conversion efficiency up to 82.1% but also exhibit tunable stiffness by varying TA concentration. Notably, we demonstrate that softer NCs achieve superior accumulation in infected tissues and deeper penetration into bacterial biofilms, leading to a significantly enhanced antibacterial performance. Furthermore, the NCs exhibit pH-responsive degradation within acidic infection microenvironments, releasing TA with potent anti-inflammatory activity. This synergistic integration of NIR-II imaging-guided high-efficiency PTT and inflammation modulation enables the effective treatment of both superficial (e.g., wounds) and deep-tissue (e.g., pneumonia) bacterial infections. This work highlights carrier stiffness as a crucial design parameter for developing advanced antimicrobial nanotherapeutics.
{"title":"Stiffness-Tunable Phenolic Nanocapsules Loaded with J-Aggregates for Near-Infrared II Imaging-Guided Phototherapy of Bacterial Infections","authors":"Yuan Tian, Keke Fan, Ruichao Qu, Jing Yu, Jingyi Jin, Mengqi Li, Liheng Feng, Jiwei Cui","doi":"10.1021/acsnano.5c19432","DOIUrl":"https://doi.org/10.1021/acsnano.5c19432","url":null,"abstract":"Near-infrared II (NIR-II) imaging-guided photothermal therapy (PTT) represents a promising noninvasive strategy for treating bacterial infections. However, its efficacy is often limited by poor agent accumulation at infection sites and insufficient penetration into biofilms. Herein, we developed stiffness-tunable phenolic nanocapsules (NCs) loaded with NIR-II J-aggregates for enhanced biofilm phototherapy. Specifically, the NIR-II photothermal molecule of BTPTIC was synthesized and assembled with 8-arm-PEG-OH to form J-aggregates (BTPTIC@PEG J-aggregates). The BTPTIC@PEG J-aggregates were used as mineralizers to synthesize zeolitic imidazolate framework-8 (ZIF-8), followed by template etching with tannic acid (TA) to obtain J-aggregate-loaded phenolic NCs (BTPTIC@PEG-TA NCs). The resulting NCs not only display strong NIR-II fluorescence and a high photothermal conversion efficiency up to 82.1% but also exhibit tunable stiffness by varying TA concentration. Notably, we demonstrate that softer NCs achieve superior accumulation in infected tissues and deeper penetration into bacterial biofilms, leading to a significantly enhanced antibacterial performance. Furthermore, the NCs exhibit pH-responsive degradation within acidic infection microenvironments, releasing TA with potent anti-inflammatory activity. This synergistic integration of NIR-II imaging-guided high-efficiency PTT and inflammation modulation enables the effective treatment of both superficial (e.g., wounds) and deep-tissue (e.g., pneumonia) bacterial infections. This work highlights carrier stiffness as a crucial design parameter for developing advanced antimicrobial nanotherapeutics.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"23 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146101967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CuInS2 quantum dots (CIS QDs), with tunable photoluminescence spanning from the visible to near-infrared (NIR) region, hold significant potential for consumer electronics and bioimaging due to their favorable photophysical properties and absence of toxic elements. However, their intrinsic lack of short-wavelength emission has hindered their use in white light-emitting applications. Herein, we report a facile synthesis of zinc–acetate–oleylamine (Zn–Ac–OAm) and oleylamine (OAm)-coencapsulated CIS/ZnS QDs that deliver full-spectrum sunlight-like emissions, characterized by a distinct 455 nm peak and an ultrabroad full width at half-maximum (fwhm) of 241 nm. The Zn–Ac–OAm emitter produces blue-green fluorescence, effectively compensating for the short-wavelength deficiency of the CIS/ZnS QDs. More importantly, strong interactions between Zn–Ac–OAm and CIS/ZnS QDs enable efficient energy transfer within coencapsulated structures. As a proof of concept, white light-emitting diodes (WLEDs) fabricated using these coencapsulated CIS/ZnS QDs exhibit excellent photophysical performance, achieving a high color rendering index (CRI) of 92.1 and external quantum efficiency (EQE) of 7.2%. This coencapsulation strategy, together with the elucidated photophysical mechanisms, provides viable pathways for extending the application of long-wavelength-emitting nanomaterials in next-generation lighting and display technologies.
{"title":"Nontoxic CuInS2/ZnS Colloidal Quantum Dots for White Light-Emitting Diodes","authors":"Xiangda Deng,Wenxin Yang,Tianmin Wu","doi":"10.1021/acsnano.5c12714","DOIUrl":"https://doi.org/10.1021/acsnano.5c12714","url":null,"abstract":"CuInS2 quantum dots (CIS QDs), with tunable photoluminescence spanning from the visible to near-infrared (NIR) region, hold significant potential for consumer electronics and bioimaging due to their favorable photophysical properties and absence of toxic elements. However, their intrinsic lack of short-wavelength emission has hindered their use in white light-emitting applications. Herein, we report a facile synthesis of zinc–acetate–oleylamine (Zn–Ac–OAm) and oleylamine (OAm)-coencapsulated CIS/ZnS QDs that deliver full-spectrum sunlight-like emissions, characterized by a distinct 455 nm peak and an ultrabroad full width at half-maximum (fwhm) of 241 nm. The Zn–Ac–OAm emitter produces blue-green fluorescence, effectively compensating for the short-wavelength deficiency of the CIS/ZnS QDs. More importantly, strong interactions between Zn–Ac–OAm and CIS/ZnS QDs enable efficient energy transfer within coencapsulated structures. As a proof of concept, white light-emitting diodes (WLEDs) fabricated using these coencapsulated CIS/ZnS QDs exhibit excellent photophysical performance, achieving a high color rendering index (CRI) of 92.1 and external quantum efficiency (EQE) of 7.2%. This coencapsulation strategy, together with the elucidated photophysical mechanisms, provides viable pathways for extending the application of long-wavelength-emitting nanomaterials in next-generation lighting and display technologies.","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":"276 1","pages":""},"PeriodicalIF":17.1,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146111148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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