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Evaluation of an Air-Powered Vaccine Delivery System 空气动力疫苗输送系统的评价
Pub Date : 2019-08-07 DOI: 10.21423/bovine-vol1993no27p47-49
A. Edwards, G. Stokka
The BallistiVet delivery system (BallistiVet Inc., Minneapolis, USA) has been patented as a system for the non-lethal ballistic implantation of biologicals and pharmaceuticals in animals. Tanimalshe 25-calibre hydroxypropylcellulose bullets have a hollow space where the product, such as freeze-dried vaccine, is placed for delivery. The equipment was evaluated by firing a total of 32 bullets at different angles (45 and 90°) and distances (15, 20 and 25 feet) into the neck and legs of 3 sedated 400-lb beef calves. The animals were then killed and PM examinations carried out. Some of the bullets fired at 45° appeared to bounce off the skin without penetrating, other bullets caused severe tissue destruction and haemorrhage. Only 10 bullets were recovered from muscle tissue. It was concluded that the bullets were too destructive to be considered as suitable for the delivery of biological or pharmaceutical products.
BallistiVet输送系统(BallistiVet Inc., Minneapolis, USA)作为生物制剂和药物在动物体内的非致命弹道植入系统已获得专利。动物用25口径羟丙基纤维素子弹有一个中空空间,用于放置产品(如冻干疫苗)以供输送。通过以不同角度(45°和90°)和距离(15英尺,20英尺和25英尺)向3头400磅的镇静牛肉小牛的颈部和腿部发射总共32发子弹来评估该设备。然后将这些动物杀死并进行PM检查。一些以45°角发射的子弹似乎从皮肤上弹开而没有穿透皮肤,其他子弹造成严重的组织破坏和出血。在肌肉组织中只发现了10颗子弹。结论是,这些子弹的破坏性太大,不适合用于运送生物或医药产品。
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引用次数: 1
Advances in Bovine Digital Diseases 牛数字疾病研究进展
Pub Date : 2019-08-07 DOI: 10.21423/bovine-vol1993no27p23-27
A. D. Weaver
A full week was devoted to discussion, sometimes heated, of bovine digital problems at a meeting organized by the British Cattle Veterinary Association in Liverpool, England, July 16-20, 1990. The first and last days, confined to members of the international study group on diseases of the ruminant digit (sixth meeting) involved twenty papers and considerable discussion on recent observations and studies. The three intervening days' program was a forum for an "Update in Cattle Lameness" (US $20 or £12 sterling post free from Dr. R. D. Murray, Department of Veterinary Clinical Studies, University of Liverpool Field Station, "Leahurst", Neaton, S. Wirral, Cheshire L64 7TE, England) attended by over 200 veterinarians and others, including large, predominantly European and Japanese contingents. This study was conceived in response to NCA's resolution to encourage biological and pharmaceutical manufacturers to provide tissue reaction data on all animal health products and to encourage development of acceptable alternative routes of administration to the problematic IM method.
1990年7月16日至20日,英国畜牧兽医协会在英格兰利物浦组织了一次会议,会上花了整整一周的时间讨论牛的数字问题,有时讨论得很激烈。第一天和最后一天,反刍动物趾部疾病国际研究小组(第六次会议)成员参加了20篇论文,并就最近的观察和研究进行了大量讨论。其间三天的活动是一个关于“牛跛足最新情况”的论坛(20美元或12英镑免费邮费,由Dr. D. Murray博士提供,利物浦大学野外研究站,“Leahurst”,Neaton, S. Wirral, Cheshire L64 7TE, England), 200多名兽医和其他人参加,其中包括主要来自欧洲和日本的大型队伍。NCA鼓励生物和制药制造商提供所有动物保健产品的组织反应数据,并鼓励开发可接受的替代给药途径,以替代存在问题的IM方法。
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引用次数: 1
Symposium on Bovine Digital Problems 牛数字问题专题讨论会
Pub Date : 2019-08-07 DOI: 10.21423/bovine-vol1993no27p28-31
A. D. Weaver
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引用次数: 0
Dairy cow mortality data management: the dairy certificate of death 奶牛死亡率数据管理:奶牛死亡证明
Pub Date : 2019-07-29 DOI: 10.21423/bovine-vol51no1p64-72
C. McConnel, F. Garry
On-farm cow mortality is a significant problem for North American dairies. Analysis of causes of death should provide important information about outcomes of current management, and direction for management changes required to improve cow health, production, and well-being. Currently available information about mortality losses is not useful for making appropriate changes because information gathering and storage are inadequate for that purpose. Here we propose and analyze the use of a dairy cow death certificate that provides an information gathering tool intended to improve analysis and communication about outcomes of dairy management.
农场里奶牛的死亡率是北美奶牛场的一个重要问题。对死亡原因的分析应提供有关当前管理结果的重要信息,以及改善奶牛健康、生产和福祉所需的管理变革方向。目前可获得的关于死亡率损失的信息对于作出适当的改变没有用处,因为信息的收集和储存不足以达到这一目的。在这里,我们提出并分析了奶牛死亡证明的使用,它提供了一种信息收集工具,旨在改善对奶牛管理结果的分析和沟通。
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引用次数: 9
Xylazine sedation and gunshot for depopulation of cattle 二甲肼镇静和枪决对牛种群减少的影响
Pub Date : 2019-06-01 DOI: 10.21423/BOVINE-VOL53NO2P166-168
C. Hanthorn, M. Sanderson
A depopulation protocol utilizing intramuscular sedation with xylazine followed by euthanasia via gunshot was evaluated for effectiveness and practicality in a group of 43 feedlot calves in a commercial feedlot setting. Sedation and euthanasia were successful in all 43 calves. The time required to complete the procedure was 46 minutes from the first xylazine injection to the last gunshot. Utilization of this depopulation method demonstrates that cattle in a commercial feedlot can be euthanized in a rapid manner that is practical and efficient, while also maintaining an acceptable level of animal welfare. Expansion to larger herds, including the total population of a large feedlot, may still be challenging. The use of this depopulation method should be considered for future livestock emergencies.
在一个商业饲养场环境中,对43头饲养场小牛进行了一项减少种群方案的有效性和实用性评估,该方案使用肌肉注射镇静,然后通过枪击安乐死。43头小牛的镇静和安乐死都取得了成功。从第一次注射噻嗪到最后一次射击,完成整个过程所需的时间为46分钟。利用这种减少种群的方法表明,商业饲养场的牛可以以一种快速、实用和有效的方式安乐死,同时还能保持可接受的动物福利水平。扩大到更大的畜群,包括一个大型饲养场的总人口,可能仍然具有挑战性。在未来的牲畜突发事件中应考虑使用这种减少种群的方法。
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引用次数: 0
Effect of live yeast (Saccharomyces cerevisiae boulardii CNCM I-1079) feed additive on health and growth parameters of high-risk heifers in a commercial feedlot 活酵母(Saccharomyces cerevisiae blardii CNCM I-1079)饲料添加剂对商业饲养场高风险母牛健康和生长参数的影响
Pub Date : 2019-06-01 DOI: 10.21423/BOVINE-VOL53NO2P117-127
M. Theurer, J. Fox, A. Aguilar, Henson Nielsen, J. Simpson, T. Lawrence
Saccharomyces cerevisiae boulardii CNCM I-1079 (live yeast; ProTernative®, Lallemand Animal Nutrition) was evaluated for effects on health and performance in high-risk feeder heifers. A total of 1,274 beef heifers (average body weight = 547 ± 28.7 lb; 248 ± 13.0 kg) were procured from auction markets in the southern United States. Heifers were randomly assigned to 1 of 2 treatments: 1) Control (CON; no yeast products) or 2) ProTernative® (PRO) fed at 1 gram/hd/day to provide 20 x 109 CFU/hd/day for the first 45 days-on-feed (8 pens/treatment). After 45 days-on-feed, PRO was removed from the diet and both the PRO and CON treatment groups were fed the same basal diets throughout the rest of finishing. Feeding PRO during the first 45 days decreased bovine respiratory disease first treatment 28.4% compared to CON (P=0.01), and improved average daily gain (P=0.05; +4.5%), feed:gain (P=0.02; -5.0%), cost of gain (P=0.04; -4.7%), percentage USDA quality grade Choice (P<0.01; +6.8%), and reduced A+ liver abscesses (P<0.01; -45.9%). Carcass weight and percentage USDA Choice carcasses decreased (P<0.01) concomitant with increased (P<0.01) percentage USDA Select carcasses as the number of times treated for bovine respiratory disease increased. Addition of PRO to the ration during the first 45 days improved health, performance, and carcass outcomes through closeout in high-risk feeder heifers.
博氏酿酒酵母CNCM I-1079(活酵母;本研究评估了ProTernative®(Lallemand Animal Nutrition)对高风险饲养小母牛的健康和生产性能的影响。共有1,274头肉牛(平均体重= 547±28.7磅;248±13.0 kg)从美国南部的拍卖市场采购。母牛随机分为两组:1)对照组(CON;不含酵母产品)或2)ProTernative®(PRO),以1 g /hd/天的剂量饲喂,在前45天(8个栏/处理)提供20 × 109 CFU/hd/天。饲喂45 d后,将PRO从饲粮中去除,在育肥期其余时间内,PRO组和CON组均饲喂相同的基础饲粮。前45 d饲喂PRO,与CON相比,首次治疗牛呼吸道疾病降低28.4% (P=0.01),平均日增重提高(P=0.05;+4.5%),料重比(P=0.02;-5.0%)、收益成本(P=0.04;-4.7%),美国农业部质量等级选择百分比(P<0.01;+6.8%), A+型肝脓肿减少(P<0.01;-45.9%)。随着呼吸系统疾病处理次数的增加,胴体重和USDA选择胴体百分比降低(P<0.01), USDA选择胴体百分比增加(P<0.01)。在前45天的日粮中添加PRO可改善高风险饲养母牛的健康状况、生产性能和屠宰结局。
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引用次数: 4
Case Report - Chronic oak toxicity (Quercus suber) in beef cattle in the south of Portugal 病例报告-葡萄牙南部肉牛慢性橡树毒性(栎属)
Pub Date : 2019-06-01 DOI: 10.21423/BOVINE-VOL53NO2P170-176
C. Frias, P. Simões, J. Cota, H. Pissarra, T. P. Nunes, C. Hjerpe, M. S. Lima
Oak toxicity in cattle results from ingestion of acorns, buds, leaves, sprouts, and saplings from several species of trees in the genus Quercus, all of which contain high concentrations of tannins. Consumption of acorns by ruminants, principally between late summer and early winter, is common in the south of Portugal, where there is a high prevalence of Quercus suber. Oak poisoning can lead to progressive damage to the kidneys and may result in renal failure and death. This study involved 17 beef cows that died of chronic oak poisoning related to ingestion of Quercus suber. The most relevant findings from necropsy examinations were abdominal fluid accumulation, atrophic/fibrotic kidneys, mesenteric and sub-mandibular edema, absence of body fat reserves and muscle atrophy, and weight loss. The most significant histopathologic finding was chronic interstitial nephritis. Elevated blood urea nitrogen, creatinine, and K+ values and reduced albumin values were found in 4 cows examined ante-mortem. Straight-bred Mertolengo cows appeared to be highly resistant to oak toxicity.
橡树对牛的毒性是由于摄入了栎属几种树木的橡子、芽、叶、芽和树苗,这些树木都含有高浓度的单宁。反刍动物食用橡子,主要在夏末和初冬之间,在葡萄牙南部很常见,那里有高流行率的栓皮栎。橡木中毒可导致肾脏逐渐受损,并可能导致肾功能衰竭和死亡。这项研究涉及17头死于慢性橡树中毒的肉牛,这些中毒与摄入栓皮栎有关。尸检最相关的发现是腹部积液、肾脏萎缩/纤维化、肠系膜和下颌下水肿、体脂肪储备缺失、肌肉萎缩和体重减轻。最重要的组织病理学发现是慢性间质性肾炎。4头死前检测的奶牛血尿素氮、肌酐、K+值升高,白蛋白值降低。纯种Mertolengo奶牛似乎对橡树的毒性有很强的抵抗力。
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引用次数: 1
Single-use hypodermic needles and obstetric sleeves failed to reduce bovine leukemia virus transmission in three dairy herds 在三个奶牛群中,一次性皮下注射针头和产科套未能减少牛白血病病毒的传播
Pub Date : 2019-06-01 DOI: 10.21423/BOVINE-VOL53NO2P128-133
V. J. Ruggiero, P. Bartlett
The objective of this study was to determine the utility of single-use hypodermic needles and reproductive examination sleeves in reducing the transmission of bovine leukemia virus (BLV) in dairy herds. Numerous epidemiological studies have identified re-use of needles and exam sleeves as significant risk factors for BLV, therefore adopting a practice of single-use needles and sleeves is a commonly suggested management change for reducing BLV transmission. We conducted a field trial on 3 midwestern commercial dairy herds that had not been employing single use of needles or sleeves as part of their herd health protocol. Additionally, each of the herds had a BLV prevalence among adult cows of at least 20%. BLV milk-ELISA negative cows were randomly assigned to always receive a new single-use needle and new exam sleeve (intervention group). We also monitored and tested BLV milk-ELISA negative cows that received the standard management practice of needles and sleeves that were shared with ELISA-positive herd mates (controls). Cumulative incidence of new infections was determined by semiannual BLV milk-ELISA testing. The cumulative incidence of new BLV infections was not statistically different between the 2 groups. Medical hygiene to prevent bloodborne transmission is still recommended, but in these 3 herds, re-use of needles and sleeves did not appear to be a major route of BLV transmission.
本研究的目的是确定一次性皮下注射针头和生殖检查套在减少奶牛群中牛白血病病毒(BLV)传播方面的效用。许多流行病学研究已经确定重复使用针头和检查套是BLV的重要危险因素,因此,采用一次性针头和检查套的做法是减少BLV传播的一种普遍建议的管理改变。我们对3个中西部商业奶牛群进行了现场试验,这些奶牛群没有将一次性使用针头或套筒作为其牛群健康方案的一部分。此外,每个牛群的成年奶牛中BLV的患病率至少为20%。BLV乳汁elisa阴性的奶牛随机分配接受新的一次性针头和新的检测套(干预组)。我们还监测和测试了BLV牛奶- elisa阴性的奶牛,这些奶牛接受了与elisa阳性牛群(对照组)共享的针和套的标准管理实践。通过半年一次的BLV牛奶- elisa检测来确定新感染的累积发生率。两组间新发BLV感染的累计发生率无统计学差异。仍建议采取医疗卫生措施预防血源性传播,但在这3个畜群中,重复使用针头和袖子似乎不是BLV传播的主要途径。
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引用次数: 6
Effect of distal splitting the scrotum when banding feedlot bulls on performance outcomes and healing time 系带时远端切开阴囊对公牛生产性能和愈合时间的影响
Pub Date : 2019-06-01 DOI: 10.21423/bovine-vol53no2p160-165
M. Theurer, J. Fox, Travis M. McCarty, Ryan M. McCollum, Clyde D. Cranwell
Castration of bulls using high tension banding techniques is a common practice in commercial feedlots. The objective of this study was to evaluate whether splitting the scrotum at time of banding would impact performance and healing times in feedlot bulls. A total of 32 bulls from a single breeding operation were blocked by initial body weight and then randomly assigned to intact (n = 16) or split (n = 16) treatment groups. A Newberry knife was used to make a 3-inch (7.6 cm) side-to-side incision through the distal scrotum immediately after banding bulls in the split treatment group. Bulls in the intact group were banded, but no incision was made in the scrotum. Individual weights were collected on days 14, 28, and 56, and the scrotum was visually assessed at each weigh point. More (37.5%) scrotums were absent on day 28 (P=0.03), and ADG was improved at day 56 (P=0.06) in the split treatment group compared to intact treatment group. Follow up studies evaluating the inflammatory response, health, and performance outcomes are warranted to further evaluate the process of splitting the scrotum at the time of band castration.
在商业饲养场使用高张力带技术阉割公牛是一种常见的做法。本研究的目的是评估在系带时分裂阴囊是否会影响饲养场公牛的生产性能和愈合时间。将单次繁育的32头公牛按初始体重进行封堵,然后随机分为完整处理组(n = 16)和分割处理组(n = 16)。劈开治疗组在将牛系带后立即用纽贝里刀在阴囊远端做一个3英寸(7.6厘米)的左右切口。在公牛的完整组是带状的,但没有在阴囊做切口。在第14、28和56天收集个体体重,并在每个体重点目测阴囊。第28天阴囊缺失率(37.5%)高于完整治疗组(P=0.03),第56天ADG明显高于完整治疗组(P=0.06)。评估炎症反应、健康和性能结果的后续研究是有必要的,以进一步评估在带状阉割时分裂阴囊的过程。
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引用次数: 2
Performance of a milk leukocyte differential test for decision-making in a selective dry cow therapy program 乳白细胞鉴别试验在选择性干牛治疗方案决策中的表现
Pub Date : 2019-06-01 DOI: 10.21423/BOVINE-VOL53NO2P150-159
J. Denis-Robichaud, R. Almeida, S. Ivey, R. Rodríguez, M. Payne, K. Leslie, M. Hockett
The objectives of this study were 1) to determine the operating characteristics of a commercial milk leukocyte differential (MLD) test to detect intramammary infections in quarters of late-lactation dairy cows as compared to bacteriological culture and 2) to evaluate the milk production and udder health parameters between cows treated following blanket vs selective dry cow therapy (DCT) using the MLD test results. In a first experiment, the MLD test was compared to the bacteriological culture results (gold standard) of 363 quarters from 94 cows. The sensitivity, specificity, and predictive values for the identification of infection using the MLD test were determined. Sensitivity ranged from 44% to 77%, and specificity from 54% to 92%. In the second experiment blanket DCT was compared to selective DCT based on the results of MLD test, and treating only positive quarters; a total of 328 cows were randomly assigned to 1 of the 2 treatment groups. The proportion of quarters positive to bacteriological culture, and the incidence rate of moderate and severe cases of clinical mastitis events, did not differ between treatment groups. Results of these experiments provide information to support decision-making in a selective DCT program in low-SCC herds using the MLD test.
本研究的目的是1)确定商业乳白细胞差异(MLD)测试的运行特征,以检测四分之一的泌乳后期奶牛的乳腺内感染,并与细菌学培养进行比较;2)利用MLD测试结果评估采用毯治疗与选择性干奶牛治疗(DCT)治疗的奶牛之间的产奶量和乳房健康参数。在第一次试验中,将MLD试验与94头奶牛363节的细菌培养结果(金标准)进行了比较。确定了使用MLD试验识别感染的敏感性、特异性和预测值。敏感性为44% ~ 77%,特异性为54% ~ 92%。在第二个实验中,根据MLD试验的结果,将毯子DCT与选择性DCT进行比较,并仅治疗阳性部位;328头奶牛随机分为1个处理组。各治疗组间细菌培养阳性率、临床乳腺炎事件中、重度病例发生率无显著差异。这些实验的结果为支持在低scc畜群中使用MLD测试进行选择性DCT计划的决策提供了信息。
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引用次数: 2
期刊
The Bovine practitioner
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