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The 13th International Conference on Solid-State Sensors, Actuators and Microsystems, 2005. Digest of Technical Papers. TRANSDUCERS '05.最新文献

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A lateral field-emission RF MEMS device [resonator filter applications] 一种横向场发射RF MEMS器件[谐振器滤波器应用]
K. Yamashita, W. Sun, K. Kakushima, H. Fujita, H. Toshiyoshi
We present the concept, fabrication, simulation, and experimental result of a field emission RF MEMS device based on SOI technology. The objective of this project is to enable RF filtering by means of a mechanical resonator. Current results include: (1) successful demonstration of the field emission effect on a reference device between silicon tips at /spl sim/5 /spl mu/m gap distance below 2/spl times/10/sup -8/ torr high vacuum environment; and (2) sacrificial release of the 2/sup nd/ generation device with integrated micro-oscillator.
我们提出了一种基于SOI技术的场发射RF MEMS器件的概念、制造、仿真和实验结果。该项目的目标是通过机械谐振器实现射频滤波。目前的研究成果包括:(1)在/spl sim/5 /spl mu/m间隙距离低于2/spl倍/10/sup -8/ torr的高真空环境下,成功论证了硅尖间参考器件的场发射效应;(2)牺牲释放集成微振荡器的2/sup / generation器件。
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引用次数: 0
An in-plane microneedles used for sampling and glucose analysis 用于取样和葡萄糖分析的平面内微针
R. Liu, X.H. Wang, F. Tang, Y. Feng, Z. Zhou
We report here the design, fabrication and experiments of a hollow in-plane microneedle, with which a biosensor is integrated to extract interstitial fluid from skin for glucose measurement. The design of hollow in-plane microneedles leads to a simple fabrication process. Different from common methods for immobilizing enzyme, we use capillary force to immobilize enzyme on the surface of microelectrodes. The experimental results showed a good linearity for the characteristic curve of glucose concentration, when it varies from 0 to 500mg/dl with respect to current signal value. The sensitivity of 0.4238nA was obtained.
我们在此报告了一种中空的平面内微针的设计、制造和实验,该微针与生物传感器集成在一起,可以从皮肤中提取间质液用于葡萄糖测量。平面内空心微针的设计使得制作工艺简单。与常用的固定化酶的方法不同,我们利用毛细管力将酶固定在微电极表面。实验结果表明,葡萄糖浓度随电流信号值在0 ~ 500mg/dl范围内变化,其特征曲线呈良好的线性关系。灵敏度为0.4238nA。
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引用次数: 5
Optical bio-sniffer (biochemical gas sensor) for dimethyl sulfide vapor 二甲基硫化物蒸汽光学生物嗅探器(生化气体传感器)
K. Mitsubayashi, Y. Hashimoto, T. Kon, T. Minamide, M. Taniguchi, H. Saito
An optical gas-sensor (bio-sniffer) for dimethyl sulfide (seaweed-odor substance) was constructed by immobilizing flavin-containing monooxygenase (FMO) to an oxygen-sensitive optical fiber. The sniffer was calibrated against gaseous DMS over the range of 10-100 ppm.
将含黄素单加氧酶(FMO)固定在氧敏光纤上,构建了海藻气味物质二甲基硫化物的光学气体传感器(生物嗅探器)。嗅探器在10-100 ppm的范围内对气体DMS进行校准。
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引用次数: 3
Integrated bio/chemical sensing system with a microfluidic transport module based on electrowetting 基于电润湿的微流体传输模块集成生物/化学传感系统
W. Satoh, H. Hosono, H. Suzuki
An integrated micro analysis system was fabricated using a microfluidic transport system driven by electrowetting and an air-gap ammonia sensor. The basic element in the system was a row of elongated gold working electrodes and a protruding polydimethylsiloxane (PDMS) structure which form an open channel structure. The wettability of the gold electrode was changed by applying a negative potential with respect to a Ag/AgCl electrode, and a solution introduced from an inlet was mobilized through the gap between the working electrode and the protruding structure. Also, a solution could be transported to any desired directions without using any valves. Furthermore, two solutions could be mixed based on the same principle. The open structure of the flow channel facilitated the integration of an air-gap ammonia sensor. Ammonia diffused from the mixing area was detected as the potential change of a pH-indicator electrode. The 90% response time was 45 s for 10 mM ammonia. The relation between the potential of the pH-indicator electrode and the logarithm of ammonia concentration was linear. Furthermore, a biosensing system was constructed by using immobilized urease or creatinine deiminase and the ammonia sensor. The concentration of urea and creatinine could be determined by measuring ammonia produced enzymatically from a sample solution. Linear calibration plot was obtained for urea concentrations down to 100 /spl mu/M and creatinine concentration down to 50 /spl mu/M.
采用电润湿驱动的微流控输运系统和气隙氨传感器组成了一个集成的微分析系统。该系统的基本元件是一排细长的金工作电极和一个突出的聚二甲基硅氧烷(PDMS)结构,形成一个开放的通道结构。通过对Ag/AgCl电极施加负电位来改变金电极的润湿性,并通过工作电极和突出结构之间的间隙调动从入口引入的溶液。此外,溶液可以输送到任何需要的方向,而不需要使用任何阀门。此外,两种解决方案可以基于相同的原则混合。流道的开放式结构便于气隙氨传感器的集成。从混合区扩散的氨气被检测为ph指示电极的电位变化。当氨浓度为10 mM时,90%的响应时间为45 s。ph指示电极电位与氨浓度的对数呈线性关系。在此基础上,构建了固定化脲酶或肌酸酐脱亚胺酶与氨传感器的生物传感系统。尿素和肌酐的浓度可以通过测定样品溶液中酶解产生的氨来测定。尿素浓度低于100 /spl mu/M,肌酐浓度低于50 /spl mu/M时,得到线性校准图。
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引用次数: 1
Densely arrayed microneedles having flow channel fabricated by mechanical dicing and anisotropic wet etching of silicon 通过硅的机械切割和各向异性湿法蚀刻制备具有流道的密集排列微针
T. Hasada, M. Shikida, K. Sato
We previously proposed a novel process combining mechanical dicing and anisotropic wet etching for fabricating arrayed MEMS structures, and used it to make solid-type microneedle structures in drug delivery systems (Shikida et al., 2004). For this report, we further developed the fabrication process for embedding two types of flow channels in our microneedle structures. One type has a channel with an opening at the base of each needle, and the other type has a cored channel in the needle. The height and pitch of the needles were 120-550 /spl mu/m and 230-370 /spl mu/m, respectively. The new process does not include the expensive deep RIE process, and is applicable to disposable injection and extraction needles used in bio-medical applications.
我们之前提出了一种结合机械切割和各向异性湿法蚀刻来制造阵列MEMS结构的新工艺,并将其用于制造药物输送系统中的固体型微针结构(Shikida et al., 2004)。在本报告中,我们进一步开发了在微针结构中嵌入两种流动通道的制造工艺。一种类型在每根针的基部具有开口的通道,而另一种类型在针中具有带芯的通道。针高为120 ~ 550 /亩/米,针距为230 ~ 370 /亩/米。新工艺不包括昂贵的深度RIE工艺,适用于生物医学应用中使用的一次性注射和提取针。
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引用次数: 2
Magnetic resonance microsystems for life science applications 生命科学应用的磁共振微系统
L. Fan, W. Huang, C. Cheng, P. Chu, H. Hao, C. Hsieh, S. H. Hsu, A. Chin, K. Hsueh, C. Lee, J. Chang, E. Liu, A. Huang, Chen-Fu Chien, A. Yeh, J. Chen, W. Wu, C. Lai
Nuclear magnetic (MR) resonance spectroscopy and imaging technique are powerful methods available for determining molecular structures and non-invasive 3D imaging. In the effort of developing a nanoMRI microsystem, the authors have designed, fabricated, assembled and did preliminary characterization of the nanoMRI probe. A multilayer high aspect ratio metal process has been developed for this project. NanoMRI probes are designed through multi-physics finite element 3D analysis, integrated using the high aspect ratio process, assembled, and the RF coils are matched and tuned to a 500MHz system. Due to the large magnetic field gradients and fast switching gradient coils, the high mass-sensitivity and additional orthogonal RF signal channels, special MR pulse sequencies (Lauterbur et al., 1992) can be developed for imaging and molecular structural analysis.
核磁共振波谱和成像技术是确定分子结构和非侵入性三维成像的有力方法。在开发纳米omri微系统的过程中,作者设计、制作、组装了纳米omri探针,并对其进行了初步表征。为此开发了一种多层高纵横比金属工艺。NanoMRI探针通过多物理场有限元3D分析设计,采用高纵横比工艺集成,组装,RF线圈匹配并调谐到500MHz系统。由于大的磁场梯度和快速开关梯度线圈,高质量灵敏度和额外的正交射频信号通道,特殊的磁共振脉冲序列(Lauterbur等人,1992)可以开发成像和分子结构分析。
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引用次数: 1
A 2-D translational pinhole formed by two orthogonally moving micro-slits 由两个垂直移动的微缝形成的二维平动针孔
N. Chronis, M. Okandan, M. Baker, L. Lee
Pinhole alignment is a tedious procedure that strongly affects the overall performance of an optical system. In order to address this critical issue, we developed a 2D translational pinhole, which is formed by two orthogonally moving micro-slits. The MEMS pinhole, fabricated by a modified SUMMIT-V process, can be positioned within a range of 30/spl times/30 microns in the XY plane. Alternatively, it can be used in a scanning mode at driving frequencies up to /spl sim/200Hz without any noticeable amplitude decrease. Typical applications include confocal scanning opthalmoscopes, laser beam profilers, and MEMS confocal microscopes.
针孔对准是一个繁琐的过程,强烈影响光学系统的整体性能。为了解决这个关键问题,我们开发了一个二维平移针孔,它由两个正交移动的微缝组成。采用改进的SUMMIT-V工艺制备的MEMS针孔可以定位在XY平面的30/spl倍/30微米范围内。或者,它可以在扫描模式下使用,驱动频率高达/spl sim/200Hz,没有任何明显的幅度下降。典型的应用包括共聚焦扫描眼显微镜、激光束剖面仪和MEMS共聚焦显微镜。
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引用次数: 2
A fully-integrated microfluidic chip for RNA-virus detection 用于rna病毒检测的全集成微流控芯片
F. Huang, C. Liao, Gwo-Bin Lee
The study presents a new fully-integrated microfluidic chip capable of performing reverse transcription polymerase chain reaction (RT-PCR) (Obeid et al., 2003), transportation of DNA/RNA samples, capillary electrophoresis (CE) separation and on-line detection. In the proposed device, dengue-2 RNA-virus was synthesized to complementary DNA (cDNA) and replicated using a RT-PCR module and then transported by a pneumatic micropump to CE sample reservoir. The cDNA samples were separated electrophoretically and detected by buried optical fibers. We have successfully demonstrated the detection of a RNA-virus using less time and less consumption of samples and reagents. The developed microfluidic chip could provide a powerful tool for fast disease diagnosis.
该研究提出了一种新的全集成微流控芯片,能够进行逆转录聚合酶链反应(RT-PCR) (Obeid et al., 2003), DNA/RNA样品运输,毛细管电泳(CE)分离和在线检测。在该装置中,将登革热-2 rna -病毒合成为互补DNA (cDNA),并使用RT-PCR模块进行复制,然后通过气动微泵将其运送到CE样品库中。cDNA样品电泳分离,埋地光纤检测。我们已经成功地证明了用更少的时间和更少的样品和试剂的消耗来检测rna病毒。所研制的微流控芯片为疾病的快速诊断提供了有力的工具。
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引用次数: 1
A microfabricated narrow gap biofuel cell with membraneless design flexibility 具有无膜设计灵活性的微制造窄间隙生物燃料电池
N. Korivi, Jin-Woo Choi
This paper presents the development and characterization of a microfabricated membraneless biofuel cell on a polymer microfluidic chip. The developed microscale biofuel cell utilizes glucose as fuel to generate bioelectric power and produces water as by-product. The developed biofuel cell exhibits a power output (power density up to 4.66 /spl mu/W/cm/sup 2/) which can be modulated by the electrode separation. The absence of a proton exchange membrane separating the anode and cathode chambers imparts high design flexibility to the developed biofuel cell. The biofuel cell has been tested for operation in physiological levels of pH and temperature, with both flowing and static fuel conditions. Due to its relatively wide range of operational temperature and stability in flowing fuel conditions, coupled with its harmless by-products and absence of any toxic reagents, renders it highly appropriate for applications in microfluidic, implantable, and portable systems.
本文介绍了一种基于聚合物微流控芯片的无膜生物燃料电池的研制与表征。所开发的微型生物燃料电池以葡萄糖为燃料产生生物电,并产生水作为副产品。所开发的生物燃料电池具有可通过电极分离调节的输出功率(功率密度高达4.66 /spl mu/W/cm/sup 2/)。没有质子交换膜分离阳极和阴极室赋予高度的设计灵活性发展的生物燃料电池。生物燃料电池已经在生理pH值和温度水平、流动和静态燃料条件下进行了运行测试。由于其相对广泛的工作温度范围和在流动燃料条件下的稳定性,加上其无害的副产品和不含任何有毒试剂,使其非常适合应用于微流体,可植入和便携式系统。
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引用次数: 2
A humidity repellent and acid-proof self-assembling passivation for gas sensors and transducers with open surfaces 用于开放表面的气体传感器和传感器的防湿和防酸自组装钝化
T. Knittel, G. Freitag, W. Widanarto, I. Eisele
Self assembling mono layers are used to fabricate a humidity repellent and acid-proof film for transducer surface passivation. This protection can be used for silicon containing surfaces, like SiO/sub 2/ or Si/sub 3/N/sub 4/, as well as for aluminium. Etching tests with aggressive acids have shown a more than tenfold higher etching time for 110 nm aluminium layers in the case of protected surfaces. The hydrophobic characteristics are used in a gas sensor to prevent the unintentional ionic drift by surface currents. Stable operation of the gas sensors in environmental condition with r.h. up to 95% is possible.
采用自组装单层膜制备换能器表面钝化的防湿防酸膜。这种保护可用于含硅表面,如SiO/sub 2/或Si/sub 3/N/sub 4/,以及铝。腐蚀性酸的蚀刻测试表明,在受保护表面的情况下,110 nm铝层的蚀刻时间要高出十倍以上。疏水特性用于气体传感器中,以防止表面电流引起的无意离子漂移。气体传感器可以在rh高达95%的环境条件下稳定运行。
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引用次数: 1
期刊
The 13th International Conference on Solid-State Sensors, Actuators and Microsystems, 2005. Digest of Technical Papers. TRANSDUCERS '05.
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