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Impact of Aerobic Training on Cognitive Function and Quality of Life in Post Covid-19 Patients 有氧训练对新冠肺炎后患者认知功能和生活质量的影响
Pub Date : 2023-06-01 DOI: 10.21608/mjcu.2023.318245
MAHMOUD A. FOUDA, M.Sc.* NAWAL A. ABU SHADY, Ph.D.*; ADEL
.
{"title":"Impact of Aerobic Training on Cognitive Function and Quality of Life in Post Covid-19 Patients","authors":"MAHMOUD A. FOUDA, M.Sc.* NAWAL A. ABU SHADY, Ph.D.*; ADEL","doi":"10.21608/mjcu.2023.318245","DOIUrl":"https://doi.org/10.21608/mjcu.2023.318245","url":null,"abstract":".","PeriodicalId":22964,"journal":{"name":"The Medical Journal of Cairo University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135143451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Would Static and Dynamic Shoulder Ultrasound Add a Diagnostic Value in Rheumatoid Arthritis Patients? 静态和动态肩部超声在类风湿关节炎患者中的诊断价值?
Pub Date : 2023-06-01 DOI: 10.21608/mjcu.2023.318287
MARWAN M. EL TOUKHY, M.D.** MONA M. FATOUH, M.D.**; DINA H.
.
{"title":"Would Static and Dynamic Shoulder Ultrasound Add a Diagnostic Value in Rheumatoid Arthritis Patients?","authors":"MARWAN M. EL TOUKHY, M.D.** MONA M. FATOUH, M.D.**; DINA H.","doi":"10.21608/mjcu.2023.318287","DOIUrl":"https://doi.org/10.21608/mjcu.2023.318287","url":null,"abstract":".","PeriodicalId":22964,"journal":{"name":"The Medical Journal of Cairo University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135143848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Comparison between Ultrasound Guided Erector Spinae Block Using Bupivacaine Versus Parasternal Nerve Block in Pediatric Patients Undergoing Cardiac Surgery for Post-Operative Pain Management after Median Sternotomy: A Randomized Controlled Double-Blinded Study 超声引导下布比卡因与胸骨旁神经阻滞治疗小儿胸骨正中切开术后疼痛的比较:一项随机对照双盲研究
Pub Date : 2023-06-01 DOI: 10.21608/mjcu.2023.318291
AHMED KARIM MOHAMMED, M.D.*,** HAITHAM A. ABOUZEID ALI, M.D.*;
Background: Children of all ages experience pain. An explosion in pain research over the last decade has elucidated more clearly our understanding of pain mechanisms, appropriate pain assessment, and the safe applicaton of innovatve pharmacologic and non-pharmacologic strategies to treat pain in adults and children. In additon, we now understand that the negatve consequences of untreated pain may have profound efects on physiologic homeostasis, and in the case of the post-operatve patent, morbidity and mortality may be adversely afected, especially in the pediatric populaton undergoing major surgeries such as cardiothoracic surgeries. Aim of Study: The aim of this study was to compare the efficacy of Parasternal nerve vs Erector Spinae Plane Block in comparison with the control group. Patients and Methods: The study was conducted between June 2022 and January 2023 and was carried at the Cardiot-horacic Surgery Department operation theater. Patients scheduled for elective cardiac surgery for non cyanotic ASD & VSD repair were recruited in this randomized research. 3 Groups
{"title":"A Comparison between Ultrasound Guided Erector Spinae Block Using Bupivacaine Versus Parasternal Nerve Block in Pediatric Patients Undergoing Cardiac Surgery for Post-Operative Pain Management after Median Sternotomy: A Randomized Controlled Double-Blinded Study","authors":"AHMED KARIM MOHAMMED, M.D.*,** HAITHAM A. ABOUZEID ALI, M.D.*;","doi":"10.21608/mjcu.2023.318291","DOIUrl":"https://doi.org/10.21608/mjcu.2023.318291","url":null,"abstract":"Background: Children of all ages experience pain. An explosion in pain research over the last decade has elucidated more clearly our understanding of pain mechanisms, appropriate pain assessment, and the safe applicaton of innovatve pharmacologic and non-pharmacologic strategies to treat pain in adults and children. In additon, we now understand that the negatve consequences of untreated pain may have profound efects on physiologic homeostasis, and in the case of the post-operatve patent, morbidity and mortality may be adversely afected, especially in the pediatric populaton undergoing major surgeries such as cardiothoracic surgeries. Aim of Study: The aim of this study was to compare the efficacy of Parasternal nerve vs Erector Spinae Plane Block in comparison with the control group. Patients and Methods: The study was conducted between June 2022 and January 2023 and was carried at the Cardiot-horacic Surgery Department operation theater. Patients scheduled for elective cardiac surgery for non cyanotic ASD & VSD repair were recruited in this randomized research. 3 Groups","PeriodicalId":22964,"journal":{"name":"The Medical Journal of Cairo University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135143397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of Dynamic CE-MRI and DWI in Characterization of Hypervascular Focal Hepatic Lesions in Cirrhotic Liver 动态CE-MRI和DWI在肝硬化局灶性高血管病变诊断中的作用
Pub Date : 2023-06-01 DOI: 10.21608/mjcu.2023.318284
MARYSE Y. AWADALLAH, M.D.* ISLAM H. EL-SHEWI, M.D.*; AISHA
.
{"title":"Role of Dynamic CE-MRI and DWI in Characterization of Hypervascular Focal Hepatic Lesions in Cirrhotic Liver","authors":"MARYSE Y. AWADALLAH, M.D.* ISLAM H. EL-SHEWI, M.D.*; AISHA","doi":"10.21608/mjcu.2023.318284","DOIUrl":"https://doi.org/10.21608/mjcu.2023.318284","url":null,"abstract":".","PeriodicalId":22964,"journal":{"name":"The Medical Journal of Cairo University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135143400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Vestibular Rehabilitation on Dizziness and Balance Disorders in Traumatic Brain Injury Patients: A Systymatic Review 前庭康复对外伤性脑损伤患者头晕和平衡障碍的影响:系统综述
Pub Date : 2023-06-01 DOI: 10.21608/mjcu.2023.318545
AKRAM A. SAYED, Ph.D.** NAWAL A. ABU SHADY, Ph.D.*; NOUR
.
{"title":"Effect of Vestibular Rehabilitation on Dizziness and Balance Disorders in Traumatic Brain Injury Patients: A Systymatic Review","authors":"AKRAM A. SAYED, Ph.D.** NAWAL A. ABU SHADY, Ph.D.*; NOUR","doi":"10.21608/mjcu.2023.318545","DOIUrl":"https://doi.org/10.21608/mjcu.2023.318545","url":null,"abstract":".","PeriodicalId":22964,"journal":{"name":"The Medical Journal of Cairo University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135143412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rate of Conversion of Conservative Breast Surgery to Mastectomy in Patients with Early Breast Cancer Versus Late Breast Cancer after Down Staging 早期乳腺癌患者与晚期乳腺癌患者在低分期后保守乳房手术到乳房切除术的转换率
Pub Date : 2023-06-01 DOI: 10.21608/mjcu.2023.318270
BISHOY R.R. AYOUB, M.D. ISLAM K. HAMOUDA, M.Sc.; MOHAMED
Background: After lung cancer, breast cancer is the most frequent cancer among women and the second greatest cause of cancer death. Aim of Study: The rate and causes of breast conservative surgery conversion to mastectomy in early breast cancer versus down staging after neoadjuvant treatment are identified. Patients and Methods: During this study, 40 females with breast cancer were enrolled and divided into two groups. All patients were subjected to conservative breast surgery and intraoperative frozen section; 20 patients with early breast cancer andanother 20 patients who received neoadjuvant therapy. All patients were subjected to history taking, clinical examination, radiologic investigations, core biopsy, preoperative laboratory investigations and histopathological examination of excised mass. Results: There were no statistically significant differences between study groups as regard rate of conversion to mastectomy, frozen results, post-operative compilations and response and Clipping distribution. Conclusion: The rate of conversion to mastectomy, frozen results, post-operative compilations and response, and clipping distribution were similar in cases of early breast cancer and late stages subjected to neoadjuvant down staging treatment. As a result, all cases of late breast cancer were down staged using neoadjuvant therapy rather than undergoing mastectomy.
{"title":"Rate of Conversion of Conservative Breast Surgery to Mastectomy in Patients with Early Breast Cancer Versus Late Breast Cancer after Down Staging","authors":"BISHOY R.R. AYOUB, M.D. ISLAM K. HAMOUDA, M.Sc.; MOHAMED","doi":"10.21608/mjcu.2023.318270","DOIUrl":"https://doi.org/10.21608/mjcu.2023.318270","url":null,"abstract":"Background: After lung cancer, breast cancer is the most frequent cancer among women and the second greatest cause of cancer death. Aim of Study: The rate and causes of breast conservative surgery conversion to mastectomy in early breast cancer versus down staging after neoadjuvant treatment are identified. Patients and Methods: During this study, 40 females with breast cancer were enrolled and divided into two groups. All patients were subjected to conservative breast surgery and intraoperative frozen section; 20 patients with early breast cancer andanother 20 patients who received neoadjuvant therapy. All patients were subjected to history taking, clinical examination, radiologic investigations, core biopsy, preoperative laboratory investigations and histopathological examination of excised mass. Results: There were no statistically significant differences between study groups as regard rate of conversion to mastectomy, frozen results, post-operative compilations and response and Clipping distribution. Conclusion: The rate of conversion to mastectomy, frozen results, post-operative compilations and response, and clipping distribution were similar in cases of early breast cancer and late stages subjected to neoadjuvant down staging treatment. As a result, all cases of late breast cancer were down staged using neoadjuvant therapy rather than undergoing mastectomy.","PeriodicalId":22964,"journal":{"name":"The Medical Journal of Cairo University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135143413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of CSF Irrigation in Bacterial CSF Infection: A Randomized Controlled Trial 脑脊液灌洗在细菌性脑脊液感染中的作用:一项随机对照试验
Pub Date : 2023-06-01 DOI: 10.21608/mjcu.2023.318261
MOHAMED A. ABBAS, M.D.* AHMED M.Sh. ALAKHRAS, M.D.*; MOHAMED
Background: Intravenous antibiotic administration is an essential component in the management of patients with cerebrospinal fluid (CSF) infections. However, very low concentrations reach the CSF because of the blood-brain barrier. Local irrigation with antibiotics could be a promising option to enhance the outcomes for such patients. Aim of Study: In this prospective randomized trial, we evaluated whether ventricular irrigation with local antibiotics had a significant benefit in these cases. Patients and Methods: Fifty patients diagnosed with CSF infections were divided into two groups; Group I included 25 patients who had CSF irrigation with local antibiotics, and Group II included the remaining patients who had external ventricular drainage (EVD) only. The main outcomes were the modified Rankin scale (MRS), the hospitalization period, and mortality. Results: Preintervention demographic, clinical, and laboratory criteria were statistically comparable between the two groups. However, patients in the irrigation group showed earlier improvement in their blood leucocytes (41 vs. 71 days), CSF leukocytes (4 vs. 12 days), and CSF proteins (12.9 vs. 27.22 days) compared to the other group. There was a significant shortening in the duration of EVD placement in the irrigation group (18 vs. 60 days in the other group). Moreover, patients in the irrigation group had a lower disability scale. Twelve patients died in the non-irrigation group (48%), which was significantly higher than the mortality rate in the irrigation group (20%). Conclusion: CSF irrigation with local antibiotics is associated with significantly better outcomes in patients with CSF infections.
{"title":"Role of CSF Irrigation in Bacterial CSF Infection: A Randomized Controlled Trial","authors":"MOHAMED A. ABBAS, M.D.* AHMED M.Sh. ALAKHRAS, M.D.*; MOHAMED","doi":"10.21608/mjcu.2023.318261","DOIUrl":"https://doi.org/10.21608/mjcu.2023.318261","url":null,"abstract":"Background: Intravenous antibiotic administration is an essential component in the management of patients with cerebrospinal fluid (CSF) infections. However, very low concentrations reach the CSF because of the blood-brain barrier. Local irrigation with antibiotics could be a promising option to enhance the outcomes for such patients. Aim of Study: In this prospective randomized trial, we evaluated whether ventricular irrigation with local antibiotics had a significant benefit in these cases. Patients and Methods: Fifty patients diagnosed with CSF infections were divided into two groups; Group I included 25 patients who had CSF irrigation with local antibiotics, and Group II included the remaining patients who had external ventricular drainage (EVD) only. The main outcomes were the modified Rankin scale (MRS), the hospitalization period, and mortality. Results: Preintervention demographic, clinical, and laboratory criteria were statistically comparable between the two groups. However, patients in the irrigation group showed earlier improvement in their blood leucocytes (41 vs. 71 days), CSF leukocytes (4 vs. 12 days), and CSF proteins (12.9 vs. 27.22 days) compared to the other group. There was a significant shortening in the duration of EVD placement in the irrigation group (18 vs. 60 days in the other group). Moreover, patients in the irrigation group had a lower disability scale. Twelve patients died in the non-irrigation group (48%), which was significantly higher than the mortality rate in the irrigation group (20%). Conclusion: CSF irrigation with local antibiotics is associated with significantly better outcomes in patients with CSF infections.","PeriodicalId":22964,"journal":{"name":"The Medical Journal of Cairo University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135143437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A 12-Month Prospective Observational Study Assessing the Real-World Clinical Effectiveness and Safety of Insulin Glargine 300 U/mLInitiation After Oral Antidiabetic Drug Failure in Insulin-Naïve Individuals with Type 2 Diabetes Mellitus in Egypt: A Posthoc Subgroup Analysis [ATOS Study] 一项为期12个月的前瞻性观察研究评估了埃及Insulin-Naïve 2型糖尿病患者口服降糖药失败后甘精胰岛素300u / mg的临床有效性和安全性:一项后亚组分析[ATOS研究]
Pub Date : 2023-06-01 DOI: 10.21608/mjcu.2023.318285
MOHAMED F. AMARA, M.D.*** SALAH SHELBAYA, M.D.*; MOHAMED
Background: Reaching the HbA1c target and keeping the euglycemic state are major challenges in the management of individuals with diabetes. Given the high rate of failure of oral antidiabetic drugs (OADs) to control the glycemic state of individuals with type-2 diabetes mellitus (T2DM), other new options have emerged to replace the traditional treatments in such cases. Second-generation basal insulin glarginehas proven its safety and efficacy in improving glycemic control in individuals with uncontrolled T2DM in multiple randomized clinical trials (RCTs). Aim of Study: This study aims to assess the effectiveness and safety of insulin glargine 300U/mL (Gla-300) when added to OADs and titrated to individualized goals in real-world practice. Patient and Methods: The ATOS study was a prospective, observational, international, multicenter study to collect information on 4422 individuals with T2DMinitiating Gla-300 across 18 countries in different geographical regions, and which routinely assessed glycated hemoglobin (HbA1c) at least every 6 months (NCT03703869). Our posthocsub group analysis is a part of this large-scale multinational study that analyzed the data collected from Egypt, one of the countries representing the South African region, to assess the real-world effectiveness of Gla-300 in Egyptian individuals with T2DM. The primary outcomes include an assessment of the effectiveness of Gla-300 in achieving glycemic goals measured by HbA1c after 6 months. The secondary objectives include effectiveness and safety during the extended follow-up period (12 months). Results: This posthocsubgroup analysis included 216 individuals with T2DM in Egypt with a mean age of 52.7 ( – 9.8) years. The mean body weight and bodymass index (BMI) were 86.8 ( – 13.6) and 30.6 ( – 5.0), respectively. Most included participants were on more than one concomitant OAD (mostly metformin and sulfonylureas). The HbA1c
{"title":"A 12-Month Prospective Observational Study Assessing the Real-World Clinical Effectiveness and Safety of Insulin Glargine 300 U/mLInitiation After Oral Antidiabetic Drug Failure in Insulin-Naïve Individuals with Type 2 Diabetes Mellitus in Egypt: A Posthoc Subgroup Analysis [ATOS Study]","authors":"MOHAMED F. AMARA, M.D.*** SALAH SHELBAYA, M.D.*; MOHAMED","doi":"10.21608/mjcu.2023.318285","DOIUrl":"https://doi.org/10.21608/mjcu.2023.318285","url":null,"abstract":"Background: Reaching the HbA1c target and keeping the euglycemic state are major challenges in the management of individuals with diabetes. Given the high rate of failure of oral antidiabetic drugs (OADs) to control the glycemic state of individuals with type-2 diabetes mellitus (T2DM), other new options have emerged to replace the traditional treatments in such cases. Second-generation basal insulin glarginehas proven its safety and efficacy in improving glycemic control in individuals with uncontrolled T2DM in multiple randomized clinical trials (RCTs). Aim of Study: This study aims to assess the effectiveness and safety of insulin glargine 300U/mL (Gla-300) when added to OADs and titrated to individualized goals in real-world practice. Patient and Methods: The ATOS study was a prospective, observational, international, multicenter study to collect information on 4422 individuals with T2DMinitiating Gla-300 across 18 countries in different geographical regions, and which routinely assessed glycated hemoglobin (HbA1c) at least every 6 months (NCT03703869). Our posthocsub group analysis is a part of this large-scale multinational study that analyzed the data collected from Egypt, one of the countries representing the South African region, to assess the real-world effectiveness of Gla-300 in Egyptian individuals with T2DM. The primary outcomes include an assessment of the effectiveness of Gla-300 in achieving glycemic goals measured by HbA1c after 6 months. The secondary objectives include effectiveness and safety during the extended follow-up period (12 months). Results: This posthocsubgroup analysis included 216 individuals with T2DM in Egypt with a mean age of 52.7 ( – 9.8) years. The mean body weight and bodymass index (BMI) were 86.8 ( – 13.6) and 30.6 ( – 5.0), respectively. Most included participants were on more than one concomitant OAD (mostly metformin and sulfonylureas). The HbA1c","PeriodicalId":22964,"journal":{"name":"The Medical Journal of Cairo University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135143841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunohistochemical Expression of MUC4, CD44, and Ki67/MIB1 in Different Meningioma Grades. A New Promise to Overcome the Chemoresistance Problem in Aggressive Meningioma MUC4、CD44和Ki67/MIB1在不同脑膜瘤分级中的免疫组织化学表达克服侵袭性脑膜瘤化疗耐药问题的新希望
Pub Date : 2023-06-01 DOI: 10.21608/mjcu.2023.318274
RASHA A. KHAIRY, M.D. SARA E. KHALIFA, M.D.; RASHA R.
Background: MUC4 and CD44 have been addressed as major players in the progression and chemoresistance of several tumors. Aim of Study: We aimed to elucidate the role of MUC4, CD44, and ki67 in meningiomas to detect if anti-cancer agents with mucin-depleting and proteolytic effects could help in overcoming chemoresistance in meningiomas. Material and Methods: Fifty meningioma cases were immunohistochemically tested for CD44 and MUC4. In addition to grading of meningioma, Ki67/MIB 1 labeling index was evaluated. Results: MUC4 and CD44 were expressed in 84% and 100% of our cases respectively. Significant correlation ( p =0.007) was detected between meningioma subtypes and MUC4 intensity being highest in meningothelial and lowest in fibroblastic variant. Moreover, advanced meningioma grades were positively correlated with CD44 intensity ( p <0.001) and Ki67/MIB1 labeling index ( p <0.001). In addition, both CD44 and MUC4 immunohistochemical expression showed a significant positive association with Ki67/MIB 1 labeling index ( p =0.011 and p =0.004) respectively. Conclusion: MUC4 and CD44 are upregulated in advanced meningioma WHO grades II and III and correlated with a higher Ki67/MIB 1 labeling index. Subsequently, they can adversely influence the outcome and recurrence rate in meningioma and can be targeted by an agent with mucolytic and proteolytic effects helping in overcoming the common problem of chemoresistance in aggressive meningiomas.
{"title":"Immunohistochemical Expression of MUC4, CD44, and Ki67/MIB1 in Different Meningioma Grades. A New Promise to Overcome the Chemoresistance Problem in Aggressive Meningioma","authors":"RASHA A. KHAIRY, M.D. SARA E. KHALIFA, M.D.; RASHA R.","doi":"10.21608/mjcu.2023.318274","DOIUrl":"https://doi.org/10.21608/mjcu.2023.318274","url":null,"abstract":"Background: MUC4 and CD44 have been addressed as major players in the progression and chemoresistance of several tumors. Aim of Study: We aimed to elucidate the role of MUC4, CD44, and ki67 in meningiomas to detect if anti-cancer agents with mucin-depleting and proteolytic effects could help in overcoming chemoresistance in meningiomas. Material and Methods: Fifty meningioma cases were immunohistochemically tested for CD44 and MUC4. In addition to grading of meningioma, Ki67/MIB 1 labeling index was evaluated. Results: MUC4 and CD44 were expressed in 84% and 100% of our cases respectively. Significant correlation ( p =0.007) was detected between meningioma subtypes and MUC4 intensity being highest in meningothelial and lowest in fibroblastic variant. Moreover, advanced meningioma grades were positively correlated with CD44 intensity ( p <0.001) and Ki67/MIB1 labeling index ( p <0.001). In addition, both CD44 and MUC4 immunohistochemical expression showed a significant positive association with Ki67/MIB 1 labeling index ( p =0.011 and p =0.004) respectively. Conclusion: MUC4 and CD44 are upregulated in advanced meningioma WHO grades II and III and correlated with a higher Ki67/MIB 1 labeling index. Subsequently, they can adversely influence the outcome and recurrence rate in meningioma and can be targeted by an agent with mucolytic and proteolytic effects helping in overcoming the common problem of chemoresistance in aggressive meningiomas.","PeriodicalId":22964,"journal":{"name":"The Medical Journal of Cairo University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135143842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of McKenzie Technique Combined with Ultrasound Therapy in Mechanical Neck Pain McKenzie技术联合超声治疗机械性颈痛的疗效观察
Pub Date : 2023-06-01 DOI: 10.21608/mjcu.2023.320243
MARWA Sh.M. SALEH, Ph.D., RAGIA M. KAMEL, Ph.D.; GHADA S.
.
{"title":"Effect of McKenzie Technique Combined with Ultrasound Therapy in Mechanical Neck Pain","authors":"MARWA Sh.M. SALEH, Ph.D., RAGIA M. KAMEL, Ph.D.; GHADA S.","doi":"10.21608/mjcu.2023.320243","DOIUrl":"https://doi.org/10.21608/mjcu.2023.320243","url":null,"abstract":".","PeriodicalId":22964,"journal":{"name":"The Medical Journal of Cairo University","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135145999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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The Medical Journal of Cairo University
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