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Using the ASTER GDEM v.2 Global Digital Elevation Model to Identify Areas of Possible Activation of Karst Processes in the Arkhangelsk Region (Russia) 使用ASTER GDEM v.2全球数字高程模型识别俄罗斯阿尔汉格尔斯克地区可能激活喀斯特过程的区域
IF 0.3 Q4 MULTIDISCIPLINARY SCIENCES Pub Date : 2021-01-01 DOI: 10.26907/2542-064x.2021.2.302-319
E. V. Polyakova, Y. Kutinov, A. Mineev, Z. Chistova, T. Belenovich
The possibility of applying the method of detecting drainless depressions, which is used in hydrological correction of the digital elevation model, to identify areas of probable activation of the karst processes in the territory of the Arkhangelsk region was considered. This approach is especially relevant for northern forested territories subjected to continuously increasing anthropogenic activity. Errors (depressions) eliminated by the hydrological correction procedure are not always false. They can be natural landforms, especially in karst areas. Hydrological correction of the digital elevation model of the Arkhangelsk region (based on ASTER GDEM v.2) was performed. A vector layer of depressions in the region was obtained. The density of drainless depressions per unit area was calculated. The resulting map showing the density of drainless depressions was compared with the distribution of karst rocks in the Arkhangelsk region. It was found that the areas of maximum open karst development are associated with a low density of drainless depressions. The highest density of drainless depressions occurs in the territory with carbonate-covered and buried karst.
考虑了应用数字高程模型水文校正中使用的检测无排水洼地的方法来确定阿尔汉格尔斯克地区境内可能激活喀斯特过程的区域的可能性。这种方法特别适用于受到不断增加的人为活动影响的北部森林地区。水文校正程序消除的误差(洼地)并不总是假的。它们可以是自然地貌,特别是在喀斯特地区。对基于ASTER GDEM v.2的阿尔汉格尔斯克地区数字高程模型进行水文校正。得到了该区域的凹陷矢量层。计算了单位面积无排水洼地的密度。绘制的无排水洼地密度图与阿尔汉格尔斯克地区的喀斯特岩石分布进行了比较。研究发现,开放岩溶发育最发达的地区与低密度的无排水洼地有关。无排水洼地密度最高的区域为碳酸盐岩覆盖和埋藏岩溶。
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引用次数: 0
Modern Methods of Preclinical Anticancer Drug Screening Using Test Systems Based on Cell Cultures 基于细胞培养的现代临床前抗癌药物筛选测试系统
IF 0.3 Q4 MULTIDISCIPLINARY SCIENCES Pub Date : 2021-01-01 DOI: 10.26907/2542-064x.2021.2.155-176
K. Kitaeva, A. A. Rizvanov, V. Solovyeva
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引用次数: 0
Recent Сladocera (Branchiopoda, Crustacea) in the Taphocenoses of Lakes in the Pechora River Delta (Russia) 俄罗斯Pechora河三角洲湖泊taphocenses中Сladocera(鳃足目,甲壳类)的近代性
IF 0.3 Q4 MULTIDISCIPLINARY SCIENCES Pub Date : 2021-01-01 DOI: 10.26907/2542-064x.2021.3.527-537
N. Nigmatullin, G. Nigamatzyanova, E. A. Valieva, L. Frolova
This paper presents the results of the hydrochemical, hydrobiological, and paleolimnological studies of 17 Arctic lakes in the Pechora River delta. Water samples and surface sediments were collected during the 2020 summer expedition to the Nenets State Nature Reserve. Based on the chemical composition of their waters, the studied lakes belong to the chloride class, sodium group II. Overall, they are characterized by shallow depths typical of this region, low mineralization (below 200 mg/L) and water hardness, as well as high dissolved oxygen levels. To assess the ecological status of the lakes, cladocerans and their subfossil remains, which have been widely recognized as reliable indicators for tracking long‐term changes in the development of freshwater ecosystems, were analyzed. A total of 23 cladoceran taxa were identified. The dominant species were Bosmina longispina (Leydig, 1860) and Chydorus cf. sphaericus (Müller, 1776) – either of these species, often displacing each other, prevailed in the lakes. Other cladoceran species were low-abundant and found sporadically: Sida crystallina (Müller, 1776), Pleuroxus uncinatus (Baird, 1850), Coronatella rectangula (Sars, 1862), and Bythotrephes longimanus (Leydig, 1860). The study also reports the first finding of Rhynchotalona latens (Sarmaja-Korjonen, Hakojarvi and Korhola, 2000), a rare glacial relict species with a narrow distribution range, in this region of Russia. The zoogeographical analysis of the data obtained on the identified taxa showed that species typical of the Palearctic and Holarctic zones prevail in the cladoceran communities under study.
本文介绍了北极地区17个湖泊的水化学、水生物学和古湖泊学研究的结果。2020年夏季考察涅涅茨国家自然保护区期间收集了水样和地表沉积物。根据其水体的化学成分,研究的湖泊属于氯类,钠族II。总的来说,它们的特点是该地区典型的浅深度,低矿化(低于200 mg/L)和水硬度,以及高溶解氧水平。为了评估湖泊的生态状况,对被广泛认为是跟踪淡水生态系统发展长期变化的可靠指标的枝海生物及其亚化石遗迹进行了分析。共鉴定出23个枝海分类群。优势种为长尾叶蝉(Bosmina longispina, Leydig, 1860)和圆尾叶蝉(Chydorus cfp . sphaericus, m ller, 1776),这两种常常相互取代,在湖泊中占优势。其他枝海纲物种数量较少,零星发现:Sida crystallina (m ller, 1776)、Pleuroxus uncinatus (Baird, 1850)、Coronatella rectangula (Sars, 1862)和Bythotrephes longimanus (Leydig, 1860)。该研究还报告了在俄罗斯该地区首次发现的Rhynchotalona latens (Sarmaja-Korjonen, Hakojarvi和Korhola, 2000),这是一种分布范围狭窄的稀有冰川遗存物种。对所鉴定分类群的动物地理分析表明,在研究的支洋群落中,具有古北纬带和全北极带特征的物种占优势。
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引用次数: 0
Features of Albendazole Determination and Dynamics of Its Decomposition in Biological Material 阿苯达唑的测定特点及其在生物材料中的分解动力学
IF 0.3 Q4 MULTIDISCIPLINARY SCIENCES Pub Date : 2021-01-01 DOI: 10.26907/2542-064x.2021.2.209-220
V. K. Shormanov, D. P. Shcherbakov, S. Garmonov
Albendazole ([5-(propylthio)-1H-benzimidazol-2-yl]carbamic acid methyl ester) is a benzimidazole derivative drug that has anthelmintic activity and is especially effective against various nematodes. Along with pronounced pharmacological action, this compound is toxic to humans. Cases of poisoning with this substance and other benzimidazole derivatives are not uncommon. Despite the active use of albendazole in medical practice and its toxicity, many questions of the chemical and toxicological analysis of albendazole remain practically unexplored. In this regard, it is advisable to study albendazole in chemical and toxicological terms. This paper aims to analyze the determination and dynamics of albendazole decomposition in biological material. Acetone was used as a chemical agent for albendazole isolation from the liver as a biomaterial. Purification of the obtained extracts was carried out sequentially in a column (190 × 11 mm) of silica gel L 40/100 μm (eluent – acetone-methylene chloride (9:1)) and by liquid-liquid extraction. The methods of thin-layer chromatography (TLC), high-performance liquid chromatography combined with tandem mass spectrometry (HPLC-MS/MS), UV spectrophotometry were used for identification. The quantitative content of the analyte was determined using UV spectrophotometry by the absorption of the dimethylformamide (DMF) medium at 301 nm. The level of albendazole extraction from the biomaterial was 85–88%.
阿苯达唑([5-(丙硫)- 1h -苯并咪唑-2-基]氨基甲酸甲酯)是一种苯并咪唑衍生物,具有驱虫活性,对多种线虫特别有效。除了明显的药理作用外,这种化合物对人体有毒。这种物质和其他苯并咪唑衍生物中毒的案例并不罕见。尽管阿苯达唑在医学实践中的积极使用及其毒性,但阿苯达唑的化学和毒理学分析的许多问题实际上尚未探索。在这方面,从化学和毒理学角度研究阿苯达唑是可取的。本文旨在分析阿苯达唑在生物材料中的分解测定及动力学。丙酮作为化学试剂从肝脏中分离阿苯达唑作为生物材料。提取液在L 40/100 μm硅胶柱(190 × 11 mm)(洗脱液-丙酮-二氯甲烷(9:1))中依次纯化,液-液萃取。采用薄层色谱(TLC)、高效液相色谱-串联质谱(HPLC-MS/MS)、紫外分光光度法进行鉴定。采用紫外分光光度法,在301 nm处吸收二甲基甲酰胺(DMF)介质,测定分析物的定量含量。生物材料中阿苯达唑的提取率为85 ~ 88%。
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引用次数: 0
Specific Antibodies against Binase: Preparation and Application 抗Binase特异性抗体的制备与应用
IF 0.3 Q4 MULTIDISCIPLINARY SCIENCES Pub Date : 2021-01-01 DOI: 10.26907/2542-064x.2021.4.557-568
V. Vershinina, E. Dudkina, V. Ulyanova, V. A. Kalashnikov, O. Ilinskaya
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引用次数: 0
The Problem of Dating the Kuyeda-Klyuchiki Section – a Unique Locality of Permian Vertebrates (Perm Region, Russia) Kuyeda-Klyuchiki剖面的年代测定问题——俄罗斯彼尔姆地区二叠纪脊椎动物的一个独特地区
IF 0.3 Q4 MULTIDISCIPLINARY SCIENCES Pub Date : 2021-01-01 DOI: 10.26907/2542-064x.2021.3.444-465
A. Bakaev, V. V. Bulanov, I. Ilaltdinov, D. Kozhanov, G. Ponomareva, I. Khopta
The Kueda-Klyuchiki locality of Permian vertebrates located in the south of the Perm Region in the Kuedinsky District was discovered in 2005 and quickly became known among paleontologists. The locality contains a rich complex of exceptionally preserved plants and vertebrates (fish, amphibians, and reptiles). Their remains are confined to limestones of various textures, which form two bone-bearing beds in the section of the quarry. However, the age of rocks remains a controversial issue. This research aims to analyze and compare various stratigraphic markers and discuss a number of existing stratigraphic inconsistencies in an attempt to arrive at a general conclusion about the age of the locality. According to geological survey data on a scale of 1:200 000, the Buraevo Sequence (Sheshmian Formation, Ufimian Stage) was identified in the territory of the quarry. At the boundary of the Sheshmian and Belebey Formations, a mineralogical “boundary” is observed, which is manifested in a decrease
二叠纪脊椎动物的Kueda-Klyuchiki地区位于Kuedinsky区的Perm地区南部,于2005年被发现,并迅速在古生物学家中广为人知。该地区保存了丰富的植物和脊椎动物(鱼类、两栖动物和爬行动物)。他们的遗骸被限制在各种质地的石灰石中,在采石场的部分形成了两个含骨床。然而,岩石的年龄仍然是一个有争议的问题。这项研究旨在分析和比较各种地层标志,并讨论一些现有的地层不一致,试图对该地区的年龄得出一个总的结论。根据1:20万比额的地质调查资料,在采石场范围内确定了Buraevo层序(乌米阶佘石面组)。在舍什面组和别勒贝组的界线处,观察到矿物学上的“界线”,表现为减少
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引用次数: 2
Early Permian Palaeotemperature Values Proposed for Continental Red-Bed Deposits of the Tambach Formation at the Bromacker Section bramacker剖面Tambach组陆相红层沉积的早二叠世古温度值
IF 0.3 Q4 MULTIDISCIPLINARY SCIENCES Pub Date : 2021-01-01 DOI: 10.26907/2542-064x.2021.3.338-350
F. Scholze, A. Pint
A variety of formulas can be found in the literature to convert geochemical data into absolute palaeotemperatures. In the present study, we test a formula for calculating the Early Permian (Artinskian) palaeotemperatures based on major element values from continental red-bed deposits of the Tambach Sandstone Member (Tambach Formation, Rotliegend Group) in Germany. The geochemical data used herein were extracted from a previous study on the Bromacker section. Applying the literature-based dataset constitutes the first approach aimed to a better understanding of certain local palaeoclimate aspects (i.e., mean annual temperature) and can be easily expanded to wider stratigraphic and palaeogeographic ranges through future studies.
在文献中可以找到各种公式将地球化学数据转换为绝对古温度。在本研究中,我们测试了一个基于德国Rotliegend Group Tambach组陆相红层沉积主要元素值计算早二叠世(Artinskian)古地温的公式。本文使用的地球化学数据来自先前对Bromacker剖面的研究。应用基于文献的数据集是第一个旨在更好地理解某些局部古气候方面(即年平均温度)的方法,并且可以通过未来的研究轻松扩展到更广泛的地层和古地理范围。
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引用次数: 1
Dynamics of the Borders of Phenological Seasons in the East of the Russian Plain (Kirov, Russia) 俄罗斯平原东部物候季节边界的动态变化(基洛夫,俄罗斯)
IF 0.3 Q4 MULTIDISCIPLINARY SCIENCES Pub Date : 2021-01-01 DOI: 10.26907/2542-064x.2021.2.289-301
T. Shikhova, Kirov Russia Fur Farming, A. Soloviev
Using the phenological database covering the period of 1961–2019 for Kirov (58°36' N, 49°40' E), the regional features of changes in the seasonal rhythms were analyzed. Mean values were calculated for 1981–2010. Additional types of seasonal rhythms with parameters deviating from the mean values by more than ±2σ were identified. The normal onset of spring, summer, and autumn was more characteristic of the 2000s (50–70%), while the anomalous seasons (with the onset dates and duration deviating significantly from the norm) prevailed in 1991–2000 and 2010–2019, respectively. The trend of variability in the ratio of phenological seasons (shorter winter and spring, longer summer and autumn) began in the middle of the 20th century and has persisted so far. In the last 30 years, compared with the base period of 1961–1990, winter and spring have begun later, but the onsets of summer and autumn have taken place earlier. The duration of winter and spring has kept decreasing. Summer has lengthened slightly. Autumn has become significantly longer. A negative correlation was established between the durations of autumn and winter ( r = –0.65), autumn and spring ( r = –0.61). The revealed phenological trends of the 21st century (the shift in the onset of the seasons, as well as the change in their duration and the increase in the amplitude of their time parameters) have been consistent with the modern restructuring of the climate regime. The data obtained on the dynamics of the natural seasons are important for assessing the response of natural ecosystems in the region to weather and climate fluctuations.
利用基洛夫(58°36' N, 49°40' E) 1961-2019年物候数据库,分析了季节节律变化的区域特征。计算1981-2010年的平均值。还发现了参数偏离平均值±2σ以上的其他季节节律类型。春、夏、秋的正常起降在2000年代更为明显(50 ~ 70%),而1991 ~ 2000年和2010 ~ 2019年的异常季节(起降日期和持续时间均明显偏离正常值)较为明显。物候季节比率的变率趋势(冬、春较短,夏、秋较长)始于20世纪中叶,并一直持续至今。近30年来,与基准期1961-1990年相比,冬季和春季开始较晚,而夏季和秋季开始较早。冬春持续时间不断缩短。夏天稍微延长了一些。秋天明显变长了。秋冬持续时间(r = -0.65)、秋春持续时间(r = -0.61)呈负相关。所揭示的21世纪物候趋势(季节开始的变化、季节持续时间的变化和时间参数振幅的增加)与现代气候格局的重构是一致的。获得的关于自然季节动态的数据对于评估该区域自然生态系统对天气和气候波动的反应非常重要。
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引用次数: 0
Identification of New Inhibitors of the Kinase Activity of CDK2 and CDK9 by Molecular Modeling and High-Efficiency Screening CDK2和CDK9激酶活性新抑制剂的分子模拟和高效筛选
IF 0.3 Q4 MULTIDISCIPLINARY SCIENCES Pub Date : 2021-01-01 DOI: 10.26907/2542-064x.2021.4.543-556
G. Andrianov, I. Serebriiskii
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引用次数: 0
About the Age of Fossil Flora of the Kygyltasian Regional Stage of the Upper Paleozoic in the Verkhoyansk Region, Northeastern Russia 俄罗斯东北部维尔霍扬斯克地区上古生界Kygyltasian区域阶段化石植物群的时代
IF 0.3 Q4 MULTIDISCIPLINARY SCIENCES Pub Date : 2021-01-01 DOI: 10.26907/2542-064x.2021.3.430-443
L.G. Porokhovnichenko, R. Kutygin, A. Kilyasov
The Kygyltasian Regional Stage is widespread throughout the Verkhoyansk Region, where it reflects a large transgressive-regressive cycle of the Verkhoyanian terrigenous sedimentation. Over the years, a huge amount of material has been accumulated on biostratigraphic division, facies features, and paleontological characteristics of this large stratigraphic unit, but its age is still debatable. The main fossils in the upper part of the Kygyltasian Regional Stage are higher plants, the remains of which were studied in the last century using outdated taxonomy. This study is devoted to revision of the collection of fossil plants from the type locality of the Kygyltasian Regional Stage (Western Verkhoyanie) in order to clarify the taxonomic composition and the age of the Upper Kygyltasian floristic association. The dominant cordaite leaves in the association were studied using the morphological and microstructural methods. This made it possible to clarify the previous paleontological definitions of the genus Noeggerathiopsis and bring them in line with modern taxonomy. The species Noeggerathiopsis heteroclitus Tolstych and N. khorokytica Tolstych were validated for type specimens. The following species were identified from the Upper Kygyltas Subformation of the Khorokyt section: Cordaites heteroclitus (Tolstych), C. cf. neuburgae Gluchova, C. cf. zalesskyi Durante, C. krychtofovichii (Radczenko), Cordaites ? khorokytica (Tolstych), Cordaites sp. sp. sp. sp. Rufloria ( Praerufloria ) Sphenophyllum cf. Sphenophyllum ? sp., Sphenopteris sp., Paracalamites sp. Based on the results of the study, the Upper Kygyltasian floristic association of the Western Verkhoyansk Region was compared with floristic associations of the Alykaeva Formation (Kuzbass) and the Upper Kata Subformation (Tunguska basin). From the above, the Late Carboniferous age of the upper part of the Kygyltasian Regional Stage follows. The results obtained are in good agreement with the correlation of the Verkhoyanian Carboniferous-Permian deposits for marine invertebrates.
吉尔吉斯区域阶段广泛分布于维尔霍扬斯克地区,反映了韦尔霍扬期陆源沉积的一次大型海侵-退回旋回。多年来,人们对这一大型地层单元的生物地层划分、相特征、古生物学特征等方面积累了大量资料,但其年代仍有争议。吉尔吉斯区域阶段上部的主要化石为高等植物,这些植物的遗存是在上个世纪使用过时的分类方法进行研究的。本文对Kygyltasian Regional Stage (Western Verkhoyanie)模式地区的植物化石标本进行了修订,以明确Kygyltasian Upper flora association的分类组成和时代。用形态学和显微结构的方法研究了该组合中的优势叶片。这使得澄清以前对Noeggerathiopsis属的古生物定义成为可能,并使它们与现代分类学保持一致。以Noeggerathiopsis heteroclitus Tolstych和N. khorokytica Tolstych为模式标本进行了验证。在Khorokyt剖面上Kygyltas亚组中鉴定到的种有:Cordaites heteroclitus (Tolstych), C. cfneuburgae Gluchova, C. cfzalesskyi Durante, C. krychtofovichii (Radczenko), Cordaites ?花椰菜(Tolstych), Cordaites sp. sp. Rufloria (Praerufloria)在此基础上,将西部Verkhoyansk地区上Kygyltasian的区系组合与库兹巴斯地区Alykaeva组和通古斯盆地上Kata亚组的区系组合进行了比较。由此推断出晚石炭世为吉尔吉斯区域阶段上半部分。所得结果与Verkhoyanian石炭-二叠纪海洋无脊椎动物沉积对比结果吻合较好。
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