T. Lazarevic, D. Petrovic, Ljiljana Novkovic, Katarina M. Janicijevic, Mirjana Janićijević-Petrović, A. Vujic, B. Ljujic, M. Sazdanović, Zorana Kovačević
Background/Aim. Hypervolemia is an important risk factor for the development of cardiovascular morbidity and mortality in patients treated with regular hemodialysis. There is still no reliable method for assessing the status of volemia in these patients. The aim of the study was to assess the status of volemia in patients treated with regular hemodialysis by measuring the parameters of the inferior vena cava (IVC) and bioimpedance. Methods. The effect of hemodialysis treatment on ultrasound parameters of the IVC, as well as on the parameters measured by bioimpedance, was examined before and after hemodialysis. The values of the N-terminal prohormone of brain natriuretic peptide (NT-proBNP) were measured both before and after hemodialysis. Forty-five patients were involved in this non-interventional cross-section study, including the patients treated with standard bicarbonate dialysis. According to the interdialytic yield, the patients were divided into three groups: I (up to 2,000 mL), II (2,000?3,000 mL), and III (over 3,000 mL). Results. The values of the IVC parameters and the parameters measured with bioimpedance were significantly lower after treatment with hemodialysis (p < 0.005). The third group of patients had a significantly higher total fluid volume in the body com-pared to the group I, as well as a significantly greater volume of extracellular fluid (p < 0.005). The significantly lower values of NT-proBNP in all groups (p < 0.005) were detected after hemodialysis. After treatment with hemodialysis, a positive correlation was observed between the concentration of NT-proBNP in the serum and the extracellular/intracellular water ratio. However, the correlation between NT-proBNP concentration and total fluid measured by bioimpedance spectroscopy did not reach statistical significance. Conclusion. Measurement of the IVC ultrasound parameters and volemia parameters using bioimpedance significantly contributes to the assessment of the status of volemia. Nevertheless, it cannot be used as a separate parameter, only in combination with all other methods.
{"title":"Assessment of volemia status using ultrasound examination of the inferior vena cava and spectroscopic bioimpendance in hemodialysis patients","authors":"T. Lazarevic, D. Petrovic, Ljiljana Novkovic, Katarina M. Janicijevic, Mirjana Janićijević-Petrović, A. Vujic, B. Ljujic, M. Sazdanović, Zorana Kovačević","doi":"10.2298/vsp200513131l","DOIUrl":"https://doi.org/10.2298/vsp200513131l","url":null,"abstract":"Background/Aim. Hypervolemia is an important risk factor for the development of cardiovascular morbidity and mortality in patients treated with regular hemodialysis. There is still no reliable method for assessing the status of volemia in these patients. The aim of the study was to assess the status of volemia in patients treated with regular hemodialysis by measuring the parameters of the inferior vena cava (IVC) and bioimpedance. Methods. The effect of hemodialysis treatment on ultrasound parameters of the IVC, as well as on the parameters measured by bioimpedance, was examined before and after hemodialysis. The values of the N-terminal prohormone of brain natriuretic peptide (NT-proBNP) were measured both before and after hemodialysis. Forty-five patients were involved in this non-interventional cross-section study, including the patients treated with standard bicarbonate dialysis. According to the interdialytic yield, the patients were divided into three groups: I (up to 2,000 mL), II (2,000?3,000 mL), and III (over 3,000 mL). Results. The values of the IVC parameters and the parameters measured with bioimpedance were significantly lower after treatment with hemodialysis (p < 0.005). The third group of patients had a significantly higher total fluid volume in the body com-pared to the group I, as well as a significantly greater volume of extracellular fluid (p < 0.005). The significantly lower values of NT-proBNP in all groups (p < 0.005) were detected after hemodialysis. After treatment with hemodialysis, a positive correlation was observed between the concentration of NT-proBNP in the serum and the extracellular/intracellular water ratio. However, the correlation between NT-proBNP concentration and total fluid measured by bioimpedance spectroscopy did not reach statistical significance. Conclusion. Measurement of the IVC ultrasound parameters and volemia parameters using bioimpedance significantly contributes to the assessment of the status of volemia. Nevertheless, it cannot be used as a separate parameter, only in combination with all other methods.","PeriodicalId":23531,"journal":{"name":"Vojnosanitetski pregled","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68329044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Psychotherapy in psychiatry: Subspecialization or integration","authors":"B. Stamatović-Gajić, T. Gajić","doi":"10.2298/vsp210111067s","DOIUrl":"https://doi.org/10.2298/vsp210111067s","url":null,"abstract":"<jats:p>nema</jats:p>","PeriodicalId":23531,"journal":{"name":"Vojnosanitetski pregled","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68332171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Andjelkovic, Vesna Vučinić, M. Gligorović, Jasmina Maksic
Background/Aim. The acquisition of practical skills, as with adaptive behaviour in general, is affected by an array of personal and environmental factors. The aim of this study was to determine the level of acquisition of practical adaptive skills among adults with vision impairment in comparison to the norms among the general population, and with regard to the visual status (low vision and blindness), age of vision loss onset, gender, age, living arrangements, education, and employment status. Methods. Seventy-nine persons who are blind and forty-eight volunteers with low vision with typical intellectual abilities took part in the study. The respondents were aged from 19 to 60 (M = 36.06, SD = 11.777). Practical adaptive skills were assessed using the Practical Skills domain which is part of the Adaptive Behavior Assessment System II - ABAS II. Results. The scores achieved in the skill areas of the Practical Skills domain, range from extremely low to average. Extremely low scores were detected in the Work skill area, for the skill areas of Community Use, Home Living and Health and Safety, the scores were below average, and average scores were noted in the Self-Care skill area. The degree of practical skills acquisition among persons with vision impairment depended primarily on the visual status, but a significant connection with living arrangements and employment status was also established. Conclusion. Persons with vision impairment showed significant limitations in the area of practical skills, which indicate the need for support programs designed to foster the development of self-reliance.
{"title":"The practical skills of persons with vision impairment","authors":"M. Andjelkovic, Vesna Vučinić, M. Gligorović, Jasmina Maksic","doi":"10.2298/vsp210328101a","DOIUrl":"https://doi.org/10.2298/vsp210328101a","url":null,"abstract":"Background/Aim. The acquisition of practical skills, as with adaptive behaviour in general, is affected by an array of personal and environmental factors. The aim of this study was to determine the level of acquisition of practical adaptive skills among adults with vision impairment in comparison to the norms among the general population, and with regard to the visual status (low vision and blindness), age of vision loss onset, gender, age, living arrangements, education, and employment status. Methods. Seventy-nine persons who are blind and forty-eight volunteers with low vision with typical intellectual abilities took part in the study. The respondents were aged from 19 to 60 (M = 36.06, SD = 11.777). Practical adaptive skills were assessed using the Practical Skills domain which is part of the Adaptive Behavior Assessment System II - ABAS II. Results. The scores achieved in the skill areas of the Practical Skills domain, range from extremely low to average. Extremely low scores were detected in the Work skill area, for the skill areas of Community Use, Home Living and Health and Safety, the scores were below average, and average scores were noted in the Self-Care skill area. The degree of practical skills acquisition among persons with vision impairment depended primarily on the visual status, but a significant connection with living arrangements and employment status was also established. Conclusion. Persons with vision impairment showed significant limitations in the area of practical skills, which indicate the need for support programs designed to foster the development of self-reliance.","PeriodicalId":23531,"journal":{"name":"Vojnosanitetski pregled","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68333682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Vulovic, J. Kozarski, T. Vulović, M. Spasić, Tatjana Sarenac-Vulovic, Tahir Mubarak, V. Stanković, M. Al-Shraim, Dejana Rakic
Introduction: Schwannoma, also known as neurilemmoma is a rare tumor, but it is one of the most common tumors of the peripheral nerves. It originates from Schwann cells of the peripheral nerve sheaths. Schwannoma mostly occurs in adults at the age of 20 to 70. The most common regions are head and neck, but it can occur almost anywhere in the body, or in its organs. Schwannomas are usually up to 2.5cm in size but they may grow up to 4-5. In this paper, the rare case of large Schwannoma of the median nerve in the distal part of the forearm is presented. Case report: A 46-year-old male patient was referred to a plastic surgeon with a diagnosis of lipoma on the anterior side of the distal third of the left forearm. Ultrasound and magnetic resonance imaging were performed and the surgery was done after that. An encapsulated tumor of the median nerve was found, and the tumor was completely removed, without nerve damage. Histological analysis showed a benign Schwannoma of cellular type and biphasic shape. In the postoperative course, there was transient paresthesia. One year after surgery, no tumor recurrence nor neurological deficit were recorded. Conclusion: Schwannoma is the most common benign tumor of peripheral nerves. Schwannomas over 5 cm in size are extremely rare. Appropriate physical examination, preoperative imaging studies, and histological verification are required for the final diagnosis. The method of choice in the treatment of large Schwannomas is complete surgical excision.
{"title":"Large Schwannoma of the median nerve at the distal forearm: Case report","authors":"D. Vulovic, J. Kozarski, T. Vulović, M. Spasić, Tatjana Sarenac-Vulovic, Tahir Mubarak, V. Stanković, M. Al-Shraim, Dejana Rakic","doi":"10.2298/vsp211010034v","DOIUrl":"https://doi.org/10.2298/vsp211010034v","url":null,"abstract":"Introduction: Schwannoma, also known as neurilemmoma is a rare tumor, but it is one of the most common tumors of the peripheral nerves. It originates from Schwann cells of the peripheral nerve sheaths. Schwannoma mostly occurs in adults at the age of 20 to 70. The most common regions are head and neck, but it can occur almost anywhere in the body, or in its organs. Schwannomas are usually up to 2.5cm in size but they may grow up to 4-5. In this paper, the rare case of large Schwannoma of the median nerve in the distal part of the forearm is presented. Case report: A 46-year-old male patient was referred to a plastic surgeon with a diagnosis of lipoma on the anterior side of the distal third of the left forearm. Ultrasound and magnetic resonance imaging were performed and the surgery was done after that. An encapsulated tumor of the median nerve was found, and the tumor was completely removed, without nerve damage. Histological analysis showed a benign Schwannoma of cellular type and biphasic shape. In the postoperative course, there was transient paresthesia. One year after surgery, no tumor recurrence nor neurological deficit were recorded. Conclusion: Schwannoma is the most common benign tumor of peripheral nerves. Schwannomas over 5 cm in size are extremely rare. Appropriate physical examination, preoperative imaging studies, and histological verification are required for the final diagnosis. The method of choice in the treatment of large Schwannomas is complete surgical excision.","PeriodicalId":23531,"journal":{"name":"Vojnosanitetski pregled","volume":"8 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68336747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Djurić, B. Stamenkovic, I. Petković, Luka Djuric
Background / Aim. Peripheral neuropathy (PN) in systemic connective tissue diseases (SCTDs) represents the apparent disease complications or initial manifestations of clinicaly undiagnosed conditions. The aim of our study was to identify neuropathies and their prevalence and point out diagnostic significance of some electrophysiological parameters in patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) and to establish their association with disease activity and duration. Methods. A prospective study was conducted at the Rheumatology Clinic of the Institute for Treatment and Rehabilitation ?Niska Banja? over a three-year-period. It included 157 patients in total, distributed as 61 with RA, 40 with SLE, and 56 with SSc. The following parameters were analyzed: age, gender, disease duration, course of disease, disease activity index, clinical rheumatological and neurological examination, neurology tests, nerve conduction study (NCS) and laboratory analyses. Results. In the studied population, we were able to identify various forms of neuropathies (in 28.7% of patients) by nerve conduction study (NCS). In all the three groups the most prevalent type of neuropathy was axonal (23,6%), sensorimotor (18,5%), polyneuropathy (23,6%). There was a significant association between disease activity and the occurrence of neuropathy (p<0.001). The most important electrophysiological parameter was SNAP amplitude n. peroneus superfitialis (70 patients; 51.9%), n. suralis (35 patients; 22.3%) and CMAP amplitude n. peroneus (32 patients; 20.8%). Disease duration in all three groups was greater in the population of patients with neuropathy. Conclusion. Neuropathies are most common in patients with longer disease duration and higher disease activity. The electrophysiological method is important in the detection of neuropathies, especially in the early detection of subclinical forms of neuropathies and the prevention of disease complications.
{"title":"Prevalence of various forms of peripheral neuropathy in patients with systemic connective tissue diseases: A clinical and electrophysiological study","authors":"V. Djurić, B. Stamenkovic, I. Petković, Luka Djuric","doi":"10.2298/vsp211005090d","DOIUrl":"https://doi.org/10.2298/vsp211005090d","url":null,"abstract":"Background / Aim. Peripheral neuropathy (PN) in systemic connective tissue diseases (SCTDs) represents the apparent disease complications or initial manifestations of clinicaly undiagnosed conditions. The aim of our study was to identify neuropathies and their prevalence and point out diagnostic significance of some electrophysiological parameters in patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) and to establish their association with disease activity and duration. Methods. A prospective study was conducted at the Rheumatology Clinic of the Institute for Treatment and Rehabilitation ?Niska Banja? over a three-year-period. It included 157 patients in total, distributed as 61 with RA, 40 with SLE, and 56 with SSc. The following parameters were analyzed: age, gender, disease duration, course of disease, disease activity index, clinical rheumatological and neurological examination, neurology tests, nerve conduction study (NCS) and laboratory analyses. Results. In the studied population, we were able to identify various forms of neuropathies (in 28.7% of patients) by nerve conduction study (NCS). In all the three groups the most prevalent type of neuropathy was axonal (23,6%), sensorimotor (18,5%), polyneuropathy (23,6%). There was a significant association between disease activity and the occurrence of neuropathy (p<0.001). The most important electrophysiological parameter was SNAP amplitude n. peroneus superfitialis (70 patients; 51.9%), n. suralis (35 patients; 22.3%) and CMAP amplitude n. peroneus (32 patients; 20.8%). Disease duration in all three groups was greater in the population of patients with neuropathy. Conclusion. Neuropathies are most common in patients with longer disease duration and higher disease activity. The electrophysiological method is important in the detection of neuropathies, especially in the early detection of subclinical forms of neuropathies and the prevention of disease complications.","PeriodicalId":23531,"journal":{"name":"Vojnosanitetski pregled","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68337005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction. Interstitial pregnancy (IP) is the rarest type of tubal pregnancy which has a high rupture rate and often remains asymptomatic in the first 10-12 gestational weeks. Therefore, the timing of the diagnosis is crucial for successful management. Case reports. Two patients, aged 24 and 22, were diagnosed with IP using transvaginal ultrasound. Both patients were asymptomatic, with initial serum bhCG of 6 664 and 4641 mIU/mL, respectively. Since they refused treatment with methotrexate and wanted to preserve their fertility, we have performed operative hysteroscopy with resection and evacuation of the gestational tissue. The procedures were uneventful. bhCG levels dropped significantly, and the patients were discharged after three and four hospital days, respectively. Conclusion. We have successfully treated two asymptomatic patients with IP of gestational age < 10 weeks by ultrasonography and levels of serum bhCG < 7000 mIU/mL. With the occurrence of IP but also numerous advantages of hysteroscopy, we aim for larger, multicenter studies to further investigate the place of this approach as a single treatment method for IP. Consequences and trends observed during the COVID 19 pandemics correlate with the importance of timely diagnosis of ectopic pregnancies, benefits of a minimally invasive approach in their treatment, and epidemiologically justified shorter hospital stay.
{"title":"Successful hysteroscopic management of two cases of interstitial pregnancy","authors":"P. Jokanovic, A. Rakić","doi":"10.2298/vsp211227020j","DOIUrl":"https://doi.org/10.2298/vsp211227020j","url":null,"abstract":"Introduction. Interstitial pregnancy (IP) is the rarest type of tubal pregnancy which has a high rupture rate and often remains asymptomatic in the first 10-12 gestational weeks. Therefore, the timing of the diagnosis is crucial for successful management. Case reports. Two patients, aged 24 and 22, were diagnosed with IP using transvaginal ultrasound. Both patients were asymptomatic, with initial serum bhCG of 6 664 and 4641 mIU/mL, respectively. Since they refused treatment with methotrexate and wanted to preserve their fertility, we have performed operative hysteroscopy with resection and evacuation of the gestational tissue. The procedures were uneventful. bhCG levels dropped significantly, and the patients were discharged after three and four hospital days, respectively. Conclusion. We have successfully treated two asymptomatic patients with IP of gestational age < 10 weeks by ultrasonography and levels of serum bhCG < 7000 mIU/mL. With the occurrence of IP but also numerous advantages of hysteroscopy, we aim for larger, multicenter studies to further investigate the place of this approach as a single treatment method for IP. Consequences and trends observed during the COVID 19 pandemics correlate with the importance of timely diagnosis of ectopic pregnancies, benefits of a minimally invasive approach in their treatment, and epidemiologically justified shorter hospital stay.","PeriodicalId":23531,"journal":{"name":"Vojnosanitetski pregled","volume":"26 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68337415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background/Aim. Although essential oil-containing mouth rinses have some advantages, it is not well-known what effects they have on the bond strength of the universal resin adhesives system to the enamel. The aim of the study was to evaluate the effect of essential oil-containing mouth rinse on the enamel bond strength of the universal adhesive system. Methods. The ninety-six bovine incisors were used. The teeth were divided into four different groups according to the control group and 3 different mouth rinses: Group I (Control) - distilled water, Group II - Listerine Cool Mint (essential oil mouth rinse), Group III - Kloroben (0.12% chlorhexidine gluconate mouth rinse) and Group IV - Oxyfresh (0.05% sodium fluoride mouth rinse). Each group was divided into two subgroups according to the application mode of the universal adhesive (etch-and-rinse mode or self-etch mode) (n = 12). Mouth rinses were applied daily for 30 sec to the enamel surfaces for a month and the samples were soaked in distilled water. After the shear bond strength (SBS) tests were performed with the universal test machine at a speed of 1 mm/min, the SBS data were statistically analyzed (p = 0.05). Results. Two-way ANOVA showed that enamel bond strength of universal adhesive was not affected by mouth rinse and was significantly affected by the application mode. Conclusion. The use of essence oil-containing mouth rinse and other mouth rinses tested in the study is safe in terms of the quality of enamel bonding of the tested adhesive.
{"title":"The effects of various mouth rinses on enamel bond strength of a universal adhesive system","authors":"M. Ayar","doi":"10.2298/vsp220405082a","DOIUrl":"https://doi.org/10.2298/vsp220405082a","url":null,"abstract":"Background/Aim. Although essential oil-containing mouth rinses have some advantages, it is not well-known what effects they have on the bond strength of the universal resin adhesives system to the enamel. The aim of the study was to evaluate the effect of essential oil-containing mouth rinse on the enamel bond strength of the universal adhesive system. Methods. The ninety-six bovine incisors were used. The teeth were divided into four different groups according to the control group and 3 different mouth rinses: Group I (Control) - distilled water, Group II - Listerine Cool Mint (essential oil mouth rinse), Group III - Kloroben (0.12% chlorhexidine gluconate mouth rinse) and Group IV - Oxyfresh (0.05% sodium fluoride mouth rinse). Each group was divided into two subgroups according to the application mode of the universal adhesive (etch-and-rinse mode or self-etch mode) (n = 12). Mouth rinses were applied daily for 30 sec to the enamel surfaces for a month and the samples were soaked in distilled water. After the shear bond strength (SBS) tests were performed with the universal test machine at a speed of 1 mm/min, the SBS data were statistically analyzed (p = 0.05). Results. Two-way ANOVA showed that enamel bond strength of universal adhesive was not affected by mouth rinse and was significantly affected by the application mode. Conclusion. The use of essence oil-containing mouth rinse and other mouth rinses tested in the study is safe in terms of the quality of enamel bonding of the tested adhesive.","PeriodicalId":23531,"journal":{"name":"Vojnosanitetski pregled","volume":"37 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68338529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vesna Nikolov, M. Radisavljevic, Boban Jelenkovic, N. Stojanovic
Background/Aim. About 10% of patients diagnosed with systemic cancer leads to the appearance of brain metastases in the central nervous system. Diseased lungs, breasts, urinary and digestive tract as well as melanoma of the skin, are increasingly treated by neurosurgeons due to their dissemination and creation of secondary deposits in the brain. Methods. The retrospective study was performed at the Clinic for Neurosurgery and the Clinic for Oncology in the period from 2018 to 2020. 111 patients with solitary changes in the brain and 122 patients with multiple changes were examined. Results. It was found that multiple metastases are more common in primary lung cancer, while single metastases are more common in adenocarcinoma, but patients with primary adenocarcinoma died in a significantly higher number. Conclusion. Surgery and radiation remain the cornerstone of therapy for symptomatic lesions; We should strive to improve surgical techniques in the direction of less damage to the surrounding healthy tissue. Radiosurgery, as well as VBRT radiation, remain the basic form in the treatment of multiple metastases.
{"title":"Current approaches to the treatment of metastatic brain tumors","authors":"Vesna Nikolov, M. Radisavljevic, Boban Jelenkovic, N. Stojanovic","doi":"10.2298/vsp220316081n","DOIUrl":"https://doi.org/10.2298/vsp220316081n","url":null,"abstract":"Background/Aim. About 10% of patients diagnosed with systemic cancer leads to the appearance of brain metastases in the central nervous system. Diseased lungs, breasts, urinary and digestive tract as well as melanoma of the skin, are increasingly treated by neurosurgeons due to their dissemination and creation of secondary deposits in the brain. Methods. The retrospective study was performed at the Clinic for Neurosurgery and the Clinic for Oncology in the period from 2018 to 2020. 111 patients with solitary changes in the brain and 122 patients with multiple changes were examined. Results. It was found that multiple metastases are more common in primary lung cancer, while single metastases are more common in adenocarcinoma, but patients with primary adenocarcinoma died in a significantly higher number. Conclusion. Surgery and radiation remain the cornerstone of therapy for symptomatic lesions; We should strive to improve surgical techniques in the direction of less damage to the surrounding healthy tissue. Radiosurgery, as well as VBRT radiation, remain the basic form in the treatment of multiple metastases.","PeriodicalId":23531,"journal":{"name":"Vojnosanitetski pregled","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68338554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pasovski Katanic, N. Rančić, Viktor Pasovski, M. Sajic, M. Resan, E. Dinčić
Background/Aim. Unilateral optic neuritis (ON), and its pathological substrate retrobulbar neuritis (RBN), is a common presenting symptom of multiple sclerosis (MS). Retina is the most proximal part of the optic pathway, and due to its close structural and physiological similarity to the CNS, often referred to as the ?window into the brain?. Our aim was to establish the diagnostic and prognostic value of structural and functional examination using novel, SS-OCT and OCTA techniques, in patients with MS who experienced RBN. Methods. We used a novel technique, optical coherent tomography (OCT) and angiography (OCTA), to examine retinal structural and functional changes in both the affected and the non-affected eye of patients with MS, and compared the findings with the healthy controls. Results. Using OCT, we found a significant difference in the structural integrity of retinal layers between the eye in which RBN had been detected, and the contralateral, non-affected eye (83.73 ? 18.36 vs 98.67 ? 11.84; p = 0.013). On the other hand, the functional examination of macular vascular plexus did not show significant differences between the affected and the non-affected eye in these patients (41.86 ? 1.52 vs 42.52 ? 1.40; p= 0.228). Interestingly, comparing the non-affected eye of patients with RBN and healthy controls, OCT examination revealed highly significant thinning in the inner plexiform layer of the macular ganglion cell layer (mGCLinpl) (61.07 ? 5.04 vs 67.53 ? 4.57; p < 0.001), showing that this may be a particularly sensitive and reliable biomarker of pathological changes in MS, and perhaps other neurodegenerative diseases. Conclusion. Overall, our research showed that OCT and OCTA offer an unprecedented opportunity for a safe, reliable and repetitive assessment of structural and functional retinal changes, as invaluable diagnostic and prognostic tools, and paving way for better understanding of pathogenic mechanisms underlying inflammatory demyelinating and neurodegenerative diseases.
背景/目的。单侧视神经炎(ON)及其病理底物球后神经炎(RBN)是多发性硬化症(MS)的常见症状。视网膜是视觉通路最近的部分，由于其结构和生理上与中枢神经系统非常相似，通常被称为“进入大脑的窗口”。我们的目的是利用新的SS-OCT和OCTA技术，在经历RBN的MS患者中建立结构和功能检查的诊断和预后价值。方法。我们使用一种新的技术，光学相干断层扫描(OCT)和血管造影(OCTA)来检查MS患者的视网膜结构和功能变化，并将结果与健康对照进行比较。结果。使用OCT，我们发现检测到RBN的眼睛和对侧未受影响的眼睛之间视网膜层结构完整性存在显著差异(83.73 ?18.36 vs 98.67 ?11.84;P = 0.013)。另一方面，黄斑血管丛功能检查在受累眼和非受累眼之间无显著差异(41.86 ?1.52 vs 42.52 ?1.40;p = 0.228)。有趣的是，比较RBN患者和健康对照组的未受影响的眼睛，OCT检查显示黄斑神经节细胞层内丛状层(mGCLinpl) (61.07 ?5.04 vs 67.53 ?4.57;p < 0.001)，表明这可能是MS病理变化的特别敏感和可靠的生物标志物，也可能是其他神经退行性疾病的生物标志物。结论。总的来说，我们的研究表明OCT和OCTA为安全、可靠和重复评估视网膜结构和功能变化提供了前所未有的机会，作为宝贵的诊断和预后工具，并为更好地理解炎症性脱髓鞘和神经退行性疾病的致病机制铺平了道路。
{"title":"Evaluation of the retinal morphological and functional findings in optic neuritis related to multiple sclerosis","authors":"Pasovski Katanic, N. Rančić, Viktor Pasovski, M. Sajic, M. Resan, E. Dinčić","doi":"10.2298/vsp220525064k","DOIUrl":"https://doi.org/10.2298/vsp220525064k","url":null,"abstract":"Background/Aim. Unilateral optic neuritis (ON), and its pathological substrate retrobulbar neuritis (RBN), is a common presenting symptom of multiple sclerosis (MS). Retina is the most proximal part of the optic pathway, and due to its close structural and physiological similarity to the CNS, often referred to as the ?window into the brain?. Our aim was to establish the diagnostic and prognostic value of structural and functional examination using novel, SS-OCT and OCTA techniques, in patients with MS who experienced RBN. Methods. We used a novel technique, optical coherent tomography (OCT) and angiography (OCTA), to examine retinal structural and functional changes in both the affected and the non-affected eye of patients with MS, and compared the findings with the healthy controls. Results. Using OCT, we found a significant difference in the structural integrity of retinal layers between the eye in which RBN had been detected, and the contralateral, non-affected eye (83.73 ? 18.36 vs 98.67 ? 11.84; p = 0.013). On the other hand, the functional examination of macular vascular plexus did not show significant differences between the affected and the non-affected eye in these patients (41.86 ? 1.52 vs 42.52 ? 1.40; p= 0.228). Interestingly, comparing the non-affected eye of patients with RBN and healthy controls, OCT examination revealed highly significant thinning in the inner plexiform layer of the macular ganglion cell layer (mGCLinpl) (61.07 ? 5.04 vs 67.53 ? 4.57; p < 0.001), showing that this may be a particularly sensitive and reliable biomarker of pathological changes in MS, and perhaps other neurodegenerative diseases. Conclusion. Overall, our research showed that OCT and OCTA offer an unprecedented opportunity for a safe, reliable and repetitive assessment of structural and functional retinal changes, as invaluable diagnostic and prognostic tools, and paving way for better understanding of pathogenic mechanisms underlying inflammatory demyelinating and neurodegenerative diseases.","PeriodicalId":23531,"journal":{"name":"Vojnosanitetski pregled","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68338906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Milica Jovanovic-Medojevic, Vanja Opacic-Galic, Katarina Geler, D. Pavlica
Background/Aim. There is no standard protocol for cleaning and desinfection of used endodontic instruments before their sterilization and reuse. The aim of this study wss to check the efficiency of the different methods of removing biological debris from different type of used hand stainless steel endodontic instruments. Methods. A total of 120 instruments (forty Kerr-Reamers, Kerr-Files and Hedstr?m-Files) (Shenzhen Denco Medical Co., Ltd. Guangdong, China) ISO 25 were analyzed. The instruments used for root canal treatment on extracted teeth were divided into 4 groups based on different decontamination protocols. The evaluation of the efficiency of the cleaning methods was based on the evaluation of the amount of stained organic residues (Van Gieson staining). Samples were analyzed by stereomicroscopy (X40). Statistical analysis was performed by Mann-Whitney and ANOVAOneWay/Bonfferoni test at a significance level of 5% (? = 0.05). Results. Residual biological debris was observed on 93.33% of all the samples taken. The thermal disinfectant cleaning method showed the lowest contamination values for all types of instruments. The method of mechanical cleaning showed the mean value of Maximum Biologic Contamination (MBC) of the Kerr-Reamers (58.54 %) and Kerr-Files (56.25%) and for Hedstr?m-Files the highest MBC was shown by the ultrasonic method contamination (50.21 %). Conclusion. The use of a thermal disinfectant was the most efficient cleaning method for all three types of hand endodontic instruments.
{"title":"Comparison of the efficiency of cleaning and disinfection protocols for hand endodontic instruments","authors":"Milica Jovanovic-Medojevic, Vanja Opacic-Galic, Katarina Geler, D. Pavlica","doi":"10.2298/vsp220913103j","DOIUrl":"https://doi.org/10.2298/vsp220913103j","url":null,"abstract":"Background/Aim. There is no standard protocol for cleaning and desinfection of used endodontic instruments before their sterilization and reuse. The aim of this study wss to check the efficiency of the different methods of removing biological debris from different type of used hand stainless steel endodontic instruments. Methods. A total of 120 instruments (forty Kerr-Reamers, Kerr-Files and Hedstr?m-Files) (Shenzhen Denco Medical Co., Ltd. Guangdong, China) ISO 25 were analyzed. The instruments used for root canal treatment on extracted teeth were divided into 4 groups based on different decontamination protocols. The evaluation of the efficiency of the cleaning methods was based on the evaluation of the amount of stained organic residues (Van Gieson staining). Samples were analyzed by stereomicroscopy (X40). Statistical analysis was performed by Mann-Whitney and ANOVAOneWay/Bonfferoni test at a significance level of 5% (? = 0.05). Results. Residual biological debris was observed on 93.33% of all the samples taken. The thermal disinfectant cleaning method showed the lowest contamination values for all types of instruments. The method of mechanical cleaning showed the mean value of Maximum Biologic Contamination (MBC) of the Kerr-Reamers (58.54 %) and Kerr-Files (56.25%) and for Hedstr?m-Files the highest MBC was shown by the ultrasonic method contamination (50.21 %). Conclusion. The use of a thermal disinfectant was the most efficient cleaning method for all three types of hand endodontic instruments.","PeriodicalId":23531,"journal":{"name":"Vojnosanitetski pregled","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68339252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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