Pub Date : 2021-12-10DOI: 10.22263/2312-4156.2021.6.99
N.A. Movsesyan, I.V. Zhiltsov, A. Kabanova, P. Plotnikov, T. Torosyan
To date, the issue of prevention and treatment of infectious and inflammatory diseases of the maxillofacial region is one of the leading unsolved problems among dental diseases. This pathology has a significant prevalence in the Republic of Belarus and in the world as a whole. The atypical clinical course of these diseases is observed with increasing frequency. There is a need for further study of the etiology and pathogenesis of inflammatory diseases of the maxillofacial region. The purpose of this study was to analyze the dynamics of pathogens prevalence of infectious and inflammatory diseases of the maxillofacial region and the changes in their sensitivity to antibiotics for 2001 and 2015-2020. The results of a bacteriological study of 1209 patients with infectious and inflammatory diseases of the maxillofacial region of odontogenic etiology undergoing inpatient treatment at the dental department of the Vitebsk Regional Clinical Hospital were analyzed. It has been found that over the last 19 years, a shift towards an increase in the number of methicillin-resistant isolates was revealed, which may indicate a decline in the effectiveness of beta-lactam antibiotics as starting empirical antibiotic therapy. The sensitivity of S.aureus and S.epidermidis isolates to cephalosporins, fluoroquinolones, lincosamides tends to decrease, the sensitivity of staphylococci to vancomycin and linezolid remains unchanged for the studied period. Streptococci have demonstrated an increase in their sensitivity to penicillins up to 100%, which indicates the rare use of these antibacterial drugs in dental hospitals. When comparing antibiotic resistance of Streptococcus spp. a tendency to the decreased sensitivity of isolates to cephalosporins of the third generation was revealed.
{"title":"THE DYNAMICS ANALYSIS OF MAXILLOFACIAL INFECTIOUS AND INFLAMMATORY DISEASES CAUSATIVE AGENTS PREVALENCE AND THE CHANGES IN THEIR SENSITIVITY TO ANTIBIOTICS","authors":"N.A. Movsesyan, I.V. Zhiltsov, A. Kabanova, P. Plotnikov, T. Torosyan","doi":"10.22263/2312-4156.2021.6.99","DOIUrl":"https://doi.org/10.22263/2312-4156.2021.6.99","url":null,"abstract":"To date, the issue of prevention and treatment of infectious and inflammatory diseases of the maxillofacial region is one of the leading unsolved problems among dental diseases. This pathology has a significant prevalence in the Republic of Belarus and in the world as a whole. The atypical clinical course of these diseases is observed with increasing frequency. There is a need for further study of the etiology and pathogenesis of inflammatory diseases of the maxillofacial region. The purpose of this study was to analyze the dynamics of pathogens prevalence of infectious and inflammatory diseases of the maxillofacial region and the changes in their sensitivity to antibiotics for 2001 and 2015-2020. The results of a bacteriological study of 1209 patients with infectious and inflammatory diseases of the maxillofacial region of odontogenic etiology undergoing inpatient treatment at the dental department of the Vitebsk Regional Clinical Hospital were analyzed. It has been found that over the last 19 years, a shift towards an increase in the number of methicillin-resistant isolates was revealed, which may indicate a decline in the effectiveness of beta-lactam antibiotics as starting empirical antibiotic therapy. The sensitivity of S.aureus and S.epidermidis isolates to cephalosporins, fluoroquinolones, lincosamides tends to decrease, the sensitivity of staphylococci to vancomycin and linezolid remains unchanged for the studied period. Streptococci have demonstrated an increase in their sensitivity to penicillins up to 100%, which indicates the rare use of these antibacterial drugs in dental hospitals. When comparing antibiotic resistance of Streptococcus spp. a tendency to the decreased sensitivity of isolates to cephalosporins of the third generation was revealed.","PeriodicalId":23571,"journal":{"name":"Vestnik of Vitebsk State Medical University","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87456991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-10DOI: 10.22263/2312-4156.2021.6.91
Y. Sirytsyna, A. P. Sivakov
Objectives. To study the efficiency and give reasons for the treatment of cervicobrachial myofascial syndrome (MFS) in patients with somatoform and autonomic dysfunctions using a complex of methods, including correction of postural muscle imbalance, reflexology and kinesiotaping. Material and methods. 49 patients took part in the study, they were divided into 2 comparison groups, matched by sex and age. Group I - the control group consisted of 24 patients who underwent a course of treatment according to the protocols and treatment standards in the Republic of Belarus. Group II - the experimental group included 25 patients who in addition to the standard course of treatment, received a complex of methods, including correction of postural muscle imbalance, reflexology and kinesiotaping. All patients underwent a clinical and neurological examination, the level of their anxiety and depressive symptoms was assessed using the Hospital Anxiety and Depression Scale - HADS (Zigmond A.S., Snaith R.P., 1983), (Russian version of Andryushchenko A.V., Drobizhev M.Yu., Dobrovolsky A.V., 2003), for the diagnosis of autonomic dysfunction the autonomic test by A.M. Wayne was used. Pain assessment was carried out using McGill’s multidimensional pain questionnaire modified by V.V. Kuzmenko. Results. A statistically significant positive effect of this treatment complex on the process of the MFS patients recovery was revealed. Conclusions. The proposed complex is gentle, non-stressful, effective and safe, which exerts a positive influence on improving the quality of medical care.
{"title":"THE SUBSTANTIATION OF COMPLEX TREATMENT FOR MYOFASCIAL SYNDROME OF CERVICOBRACHIAL LOCALIZATION IN PATIENTS WITH SOMATOFORM AUTONOMIC DYSFUNCTIONS","authors":"Y. Sirytsyna, A. P. Sivakov","doi":"10.22263/2312-4156.2021.6.91","DOIUrl":"https://doi.org/10.22263/2312-4156.2021.6.91","url":null,"abstract":"Objectives. To study the efficiency and give reasons for the treatment of cervicobrachial myofascial syndrome (MFS) in patients with somatoform and autonomic dysfunctions using a complex of methods, including correction of postural muscle imbalance, reflexology and kinesiotaping. Material and methods. 49 patients took part in the study, they were divided into 2 comparison groups, matched by sex and age. Group I - the control group consisted of 24 patients who underwent a course of treatment according to the protocols and treatment standards in the Republic of Belarus. Group II - the experimental group included 25 patients who in addition to the standard course of treatment, received a complex of methods, including correction of postural muscle imbalance, reflexology and kinesiotaping. All patients underwent a clinical and neurological examination, the level of their anxiety and depressive symptoms was assessed using the Hospital Anxiety and Depression Scale - HADS (Zigmond A.S., Snaith R.P., 1983), (Russian version of Andryushchenko A.V., Drobizhev M.Yu., Dobrovolsky A.V., 2003), for the diagnosis of autonomic dysfunction the autonomic test by A.M. Wayne was used. Pain assessment was carried out using McGill’s multidimensional pain questionnaire modified by V.V. Kuzmenko. Results. A statistically significant positive effect of this treatment complex on the process of the MFS patients recovery was revealed. Conclusions. The proposed complex is gentle, non-stressful, effective and safe, which exerts a positive influence on improving the quality of medical care.","PeriodicalId":23571,"journal":{"name":"Vestnik of Vitebsk State Medical University","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73334857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-10DOI: 10.22263/2312-4156.2021.6.56
I.A. Rutskaya, S. Pimanov
Objectives. To analyze the colon echographic images of patients suffering from pseudomembranous colitis (PMC) with COVID-19. Material and methods. 24 patients with PMC and COVID-19 (group 1), 24 patients with COVID-19 infection without diarrhea (group 2) and 24 practically healthy subjects (group 3, the control one) were examined. The diagnosis of coronavirus infection was verified by isolating SARS-CoV-2 RNA by polymerase chain reaction from the mucous membrane of the upper respiratory tract. Clostridioides difficile infection was detected by means of an immunochromatographic test with the determination of microbial toxins in the feces of patients. Ultrasound investigation (US) was performed using convex 3.5-4.0 MHz and linear 9.0-10.0 MHz probes without special preparation of patients for the examination. Results. All patients of group 1 had a thickened colon wall from 3.5 up to 11.2 mm. Among the patients of the 2nd group, the thickness of the intestinal wall in 25% of cases was up to 2 mm inclusively, in 75% - 2.1 mm or more, of which in every fourth case it exceeded 3 mm. The thickness of the bowel wall between the 1st and the 2nd groups of patients, as well as the 1st and the 3rd groups of patients, had statistically significant differences, no such pattern was found between the 2nd and the 3rd groups. The progression of ultrasound signs of colon lesions in patients suffering from PMC with COVID-19 was accompanied by a worsening of their clinical condition and the aggravation of characteristic laboratory changes. With a positive response to PMC therapy regression of ultrasound changes in the intestinal wall occurs, but there is some delay in the normalization of structural changes recorded by ultrasound. In all cases of PMC with COVID-19, a loss or weakening of the stratification of the bowel wall is observed. Tocompletion of PMC treatment when the intestinal wall thickness exceeds 4.5 mm is accompanied by the occurrence of relapses. Conclusions. Ultrasound of the intestine in patients having PMC with COVID-19 makes it possible to objectify the condition of the bowel wall and to adjust the management of patients.
{"title":"ECHOGRAPHIC CHARACTERISTICS OF THE COLON IN PATIENTS WITH PSEUDOMEMBRANOUS COLITIS IN CASE OF COVID-19","authors":"I.A. Rutskaya, S. Pimanov","doi":"10.22263/2312-4156.2021.6.56","DOIUrl":"https://doi.org/10.22263/2312-4156.2021.6.56","url":null,"abstract":"Objectives. To analyze the colon echographic images of patients suffering from pseudomembranous colitis (PMC) with COVID-19. Material and methods. 24 patients with PMC and COVID-19 (group 1), 24 patients with COVID-19 infection without diarrhea (group 2) and 24 practically healthy subjects (group 3, the control one) were examined. The diagnosis of coronavirus infection was verified by isolating SARS-CoV-2 RNA by polymerase chain reaction from the mucous membrane of the upper respiratory tract. Clostridioides difficile infection was detected by means of an immunochromatographic test with the determination of microbial toxins in the feces of patients. Ultrasound investigation (US) was performed using convex 3.5-4.0 MHz and linear 9.0-10.0 MHz probes without special preparation of patients for the examination. Results. All patients of group 1 had a thickened colon wall from 3.5 up to 11.2 mm. Among the patients of the 2nd group, the thickness of the intestinal wall in 25% of cases was up to 2 mm inclusively, in 75% - 2.1 mm or more, of which in every fourth case it exceeded 3 mm. The thickness of the bowel wall between the 1st and the 2nd groups of patients, as well as the 1st and the 3rd groups of patients, had statistically significant differences, no such pattern was found between the 2nd and the 3rd groups. The progression of ultrasound signs of colon lesions in patients suffering from PMC with COVID-19 was accompanied by a worsening of their clinical condition and the aggravation of characteristic laboratory changes. With a positive response to PMC therapy regression of ultrasound changes in the intestinal wall occurs, but there is some delay in the normalization of structural changes recorded by ultrasound. In all cases of PMC with COVID-19, a loss or weakening of the stratification of the bowel wall is observed. Tocompletion of PMC treatment when the intestinal wall thickness exceeds 4.5 mm is accompanied by the occurrence of relapses. Conclusions. Ultrasound of the intestine in patients having PMC with COVID-19 makes it possible to objectify the condition of the bowel wall and to adjust the management of patients.","PeriodicalId":23571,"journal":{"name":"Vestnik of Vitebsk State Medical University","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76065588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-10DOI: 10.22263/2312-4156.2021.6.14
M. Miadzelets
The diagnosis of perioral dermatitis is relatively easy to make in the presence of a typical clinical picture, characterized by the limited erythema around the mouth, at the background of which there are papules, micropapules, papulopustules and papulovesicles. However, in case of other rosacea-like dermatoses, such as rosacea and demodex folliculitis, difficulties can arise, especially in the presence of an atypical or a blurred clinical picture. Despite the fact that these diseases have a distinctive clinical picture and pathogenetic mechanisms, visible signs are similar, coincidence of some pathways of pathogenesis, as well as the problematical character of biopsy on the skin of the face in patients often complicate the diagnosis making. For this reason, great importance is attached to non-invasive diagnostic methods, dermatoscopic examination in particular. Despite the low magnification and resolution, this method makes it possible to assess the structure of the skin in a three-dimensional image over a sufficiently large area without damaging it. As a result of the dermatoscopic examination of 49 patients with perioral dermatitis and 54 patients with other rosacea-like dermatoses of the face (20 patients with erythematous-telangiectatic subtype of rosacea, 22 - with papulopustular rosacea subtype and 12 patients with demodicosis), the most significant for differential diagnosis dermatoscopic criteria of perioral dermatitis have been found: pink background due to the presence of erythema (69%), numerous pink micropapules (53%) and micropustules (31%), the presence of thin linearly tortuous vessels (39%) and minor follicular disorders (39%). The determined dermatoscopic features can be of a significant help in the differential diagnosis of perioral dermatitis from other dermatoses of the face.
{"title":"DIFFERENTIAL DIAGNOSIS OF PERIORAL DERMATITIS BY MEANS OF DERMATOSCOPIC METHOD OF EXAMINING","authors":"M. Miadzelets","doi":"10.22263/2312-4156.2021.6.14","DOIUrl":"https://doi.org/10.22263/2312-4156.2021.6.14","url":null,"abstract":"The diagnosis of perioral dermatitis is relatively easy to make in the presence of a typical clinical picture, characterized by the limited erythema around the mouth, at the background of which there are papules, micropapules, papulopustules and papulovesicles. However, in case of other rosacea-like dermatoses, such as rosacea and demodex folliculitis, difficulties can arise, especially in the presence of an atypical or a blurred clinical picture. Despite the fact that these diseases have a distinctive clinical picture and pathogenetic mechanisms, visible signs are similar, coincidence of some pathways of pathogenesis, as well as the problematical character of biopsy on the skin of the face in patients often complicate the diagnosis making. For this reason, great importance is attached to non-invasive diagnostic methods, dermatoscopic examination in particular. Despite the low magnification and resolution, this method makes it possible to assess the structure of the skin in a three-dimensional image over a sufficiently large area without damaging it. As a result of the dermatoscopic examination of 49 patients with perioral dermatitis and 54 patients with other rosacea-like dermatoses of the face (20 patients with erythematous-telangiectatic subtype of rosacea, 22 - with papulopustular rosacea subtype and 12 patients with demodicosis), the most significant for differential diagnosis dermatoscopic criteria of perioral dermatitis have been found: pink background due to the presence of erythema (69%), numerous pink micropapules (53%) and micropustules (31%), the presence of thin linearly tortuous vessels (39%) and minor follicular disorders (39%). The determined dermatoscopic features can be of a significant help in the differential diagnosis of perioral dermatitis from other dermatoses of the face.","PeriodicalId":23571,"journal":{"name":"Vestnik of Vitebsk State Medical University","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77049584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-10DOI: 10.22263/2312-4156.2021.6.35
Y. Khadzkou, K. Balaboshka
Objectives. To determine the effectiveness of the developed method of combined use of the fibrinolysis inhibitor aminocaproic acid, including intravenous administration and local application, during knee replacement. Material and methods. A prospective randomized study included 80 patients who had undergone total knee replacement. In the treatment of group 1 patients, the method of combined use of aminocaproic acid, including intravenous and local administration, was used. Intravenous administration of aminocaproic acid was used in the treatment of group 2 patients. Intravenous administration of tranexamic acid was used in the treatment of group 3 patients. Group 4 patients underwent operations without the application of fibrinolysis inhibitors. The indices of hemoglobin, erythrocytes, hematocrit number, blood loss volume, functional result, and also the economic costs were evaluated. Results. On the 1st and the 5th days after the operation, statistically significantly higher hemoglobin values of 129±11/120±12 g/l, the number of red blood cells 4.4±0.4/4.1±0.4*1012/l, hematocrit number 38±2.2/36±3.3 were obtained in patients of group 1 (p<0.05). The average volume of blood loss of 860 (602;1098) ml was statistically significantly lower in group 1 (p<0.05). The effective reduction of blood loss made it possible to achieve a better functional result, to eliminate the need for hemotransfusion and to reduce the economic costs in the treatment of group 1 patients. Conclusions. The developed method of combined use of the fibrinolysis inhibitor aminocaproic acid in knee arthroplasty, including intravenous administration and local application, provides favorable conditions for early activation of a patient, improves the functional result and cuts the economic costs by reducing blood loss.
{"title":"COMPARATIVE EFFECTIVENESS OF THE FIBRINOLYSIS INHIBITORS IN KNEE REPLACEMENT","authors":"Y. Khadzkou, K. Balaboshka","doi":"10.22263/2312-4156.2021.6.35","DOIUrl":"https://doi.org/10.22263/2312-4156.2021.6.35","url":null,"abstract":"Objectives. To determine the effectiveness of the developed method of combined use of the fibrinolysis inhibitor aminocaproic acid, including intravenous administration and local application, during knee replacement. Material and methods. A prospective randomized study included 80 patients who had undergone total knee replacement. In the treatment of group 1 patients, the method of combined use of aminocaproic acid, including intravenous and local administration, was used. Intravenous administration of aminocaproic acid was used in the treatment of group 2 patients. Intravenous administration of tranexamic acid was used in the treatment of group 3 patients. Group 4 patients underwent operations without the application of fibrinolysis inhibitors. The indices of hemoglobin, erythrocytes, hematocrit number, blood loss volume, functional result, and also the economic costs were evaluated. Results. On the 1st and the 5th days after the operation, statistically significantly higher hemoglobin values of 129±11/120±12 g/l, the number of red blood cells 4.4±0.4/4.1±0.4*1012/l, hematocrit number 38±2.2/36±3.3 were obtained in patients of group 1 (p<0.05). The average volume of blood loss of 860 (602;1098) ml was statistically significantly lower in group 1 (p<0.05). The effective reduction of blood loss made it possible to achieve a better functional result, to eliminate the need for hemotransfusion and to reduce the economic costs in the treatment of group 1 patients. Conclusions. The developed method of combined use of the fibrinolysis inhibitor aminocaproic acid in knee arthroplasty, including intravenous administration and local application, provides favorable conditions for early activation of a patient, improves the functional result and cuts the economic costs by reducing blood loss.","PeriodicalId":23571,"journal":{"name":"Vestnik of Vitebsk State Medical University","volume":"99 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90993363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-10DOI: 10.22263/2312-4156.2021.6.118
H. M. Biardouskaya, N.V. Miklash, H.I. Yakhimchyk, I.M. Motyuk
The article describes a rare progressive disease of the cardiovascular system, hereditary mitochondrial pathology - Barth’s syndrome (3-methylglutacone aciduria type 2). A list of diseases for the differential diagnosis is given. A case of clinical observation of Barth’s syndrome is considered. In the presented case, the disease manifested itself at the age of up to one year and was characterized by the signs of heart failure, muscle hypotension, and a decrease in the number of neutrophils in the peripheral blood. The child was repeatedly observed in the hospital, received treatment with an inhibitor of an angio-converting enzyme, digoxin, acetylsalicylic acid, was consulted by a geneticist. A splicing mutation was revealed in the 3rd exon of the taphazin gene. The combination in the clinical picture of the signs of heart failure, muscle hypotension, protein-energy insufficiency, neutropenia, onset in the first year of life, a decrease in the contractility of the left ventricular myocardium, an increase in the size of the heart and a decrease in its contractility gave rise to suspicion of this disease. Barth’s syndrome was confirmed by genetic testing.
{"title":"BARTH’S SYNDROME: BRIEF REVIEW AND CLINICAL CASE","authors":"H. M. Biardouskaya, N.V. Miklash, H.I. Yakhimchyk, I.M. Motyuk","doi":"10.22263/2312-4156.2021.6.118","DOIUrl":"https://doi.org/10.22263/2312-4156.2021.6.118","url":null,"abstract":"The article describes a rare progressive disease of the cardiovascular system, hereditary mitochondrial pathology - Barth’s syndrome (3-methylglutacone aciduria type 2). A list of diseases for the differential diagnosis is given. A case of clinical observation of Barth’s syndrome is considered. In the presented case, the disease manifested itself at the age of up to one year and was characterized by the signs of heart failure, muscle hypotension, and a decrease in the number of neutrophils in the peripheral blood. The child was repeatedly observed in the hospital, received treatment with an inhibitor of an angio-converting enzyme, digoxin, acetylsalicylic acid, was consulted by a geneticist. A splicing mutation was revealed in the 3rd exon of the taphazin gene. The combination in the clinical picture of the signs of heart failure, muscle hypotension, protein-energy insufficiency, neutropenia, onset in the first year of life, a decrease in the contractility of the left ventricular myocardium, an increase in the size of the heart and a decrease in its contractility gave rise to suspicion of this disease. Barth’s syndrome was confirmed by genetic testing.","PeriodicalId":23571,"journal":{"name":"Vestnik of Vitebsk State Medical University","volume":"125 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89847351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-10DOI: 10.22263/2312-4156.2021.6.67
R. Khokha, L. Zavodnik, A. M. Khokha, N. Paramonova, O. Vezhel
Objectives. To establish the molecular profile of sensitization to individual components of the house dust mite allergen (Der p1 and Der p2) in children of Grodno region (Republic of Belarus). Material and methods. We examined 61 children aged from 4 to 17 years with symptoms of allergy associated with house dust mite. sIgE antibodies to the house dust mite allergen components Der p1 and Der p2 were determined by the ImmunoCAP method. Results. sIgE antibodies to at least one molecule of the house dust mite allergen Der p1 and/or Der p 2 were detected in 83.6% of children. sIgE antibodies to Der p1 were found in 75.4% of children, and to Der p2 - in 70.5% of children. sIgE antibodies simultaneously to two molecular components of the dust mite (Der p1 + Der p2) were detected in 62.3% of children. With age, the ratio of Der p1 and Der p2 changes towards the prevalence of Der p2 (p=0.02). It has been found that 9.8% of children have IgE-recognizing Der p1, but not Der p 2, and 6.5% of children have IgE-recognizing Der p2, but not Der p 1. In 16.4% of children with sensitization to a house dust mite no sIgE antibodies to Der p1 and Der p2 were detected. The frequency of sensitization to Der p1 and Der p 2, depending on the degree of skin reactivity, established by the results of skin prick tests with water-salt extracts of house dust mite was as follows: «+» 31.25% and 31.25%, «++» 91,17% and 85.29%, «+++» 80% and 60%, respectively. 9.8% of children with negative skin prick test results (but increased level of sIgE to house dust mite extract) were Der p1-, Der p2- and Der p1 + Der p2-positive in 100% of cases. Conclusions. The allergenic components of house dust mite Der p1 and Der p2 are major in children of Grodno region. A component-resolved diagnostic approach to clarify the profiles of IgE-mediated reactivity in patients with allergy associated with house dust mite will allow to improve and to optimize the therapeutic and diagnostic tactics of managing such patients.
{"title":"SENSITIZATION TO MOLECULAR COMPONENTS OF HOUSE-DUST MITE ALLERGEN DER P1 AND DER P2 IN CHILDREN","authors":"R. Khokha, L. Zavodnik, A. M. Khokha, N. Paramonova, O. Vezhel","doi":"10.22263/2312-4156.2021.6.67","DOIUrl":"https://doi.org/10.22263/2312-4156.2021.6.67","url":null,"abstract":"Objectives. To establish the molecular profile of sensitization to individual components of the house dust mite allergen (Der p1 and Der p2) in children of Grodno region (Republic of Belarus). Material and methods. We examined 61 children aged from 4 to 17 years with symptoms of allergy associated with house dust mite. sIgE antibodies to the house dust mite allergen components Der p1 and Der p2 were determined by the ImmunoCAP method. Results. sIgE antibodies to at least one molecule of the house dust mite allergen Der p1 and/or Der p 2 were detected in 83.6% of children. sIgE antibodies to Der p1 were found in 75.4% of children, and to Der p2 - in 70.5% of children. sIgE antibodies simultaneously to two molecular components of the dust mite (Der p1 + Der p2) were detected in 62.3% of children. With age, the ratio of Der p1 and Der p2 changes towards the prevalence of Der p2 (p=0.02). It has been found that 9.8% of children have IgE-recognizing Der p1, but not Der p 2, and 6.5% of children have IgE-recognizing Der p2, but not Der p 1. In 16.4% of children with sensitization to a house dust mite no sIgE antibodies to Der p1 and Der p2 were detected. The frequency of sensitization to Der p1 and Der p 2, depending on the degree of skin reactivity, established by the results of skin prick tests with water-salt extracts of house dust mite was as follows: «+» 31.25% and 31.25%, «++» 91,17% and 85.29%, «+++» 80% and 60%, respectively. 9.8% of children with negative skin prick test results (but increased level of sIgE to house dust mite extract) were Der p1-, Der p2- and Der p1 + Der p2-positive in 100% of cases. Conclusions. The allergenic components of house dust mite Der p1 and Der p2 are major in children of Grodno region. A component-resolved diagnostic approach to clarify the profiles of IgE-mediated reactivity in patients with allergy associated with house dust mite will allow to improve and to optimize the therapeutic and diagnostic tactics of managing such patients.","PeriodicalId":23571,"journal":{"name":"Vestnik of Vitebsk State Medical University","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89155221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-11DOI: 10.22263/2312-4156.2021.5.84
G. V. Adamenko, D.A. Tsiomkina
The objective of the work was to develop an algorithm for pharmaceutical consulting on the sale of essential oils. To achieve the set goal of the study, a content analysis of information array of data on aromatherapy products was carried out. The data obtained made it possible to systematize aromatic agents according to groups depending on their type and application (essential oils, base oils, cosmetic oils, massage oils, agents for baths, saunas and bathtubs). Having systematized the data of literature sources, we can draw a conclusion about such properties of essential oils as tonic, relaxing, soothing, anti-stress and others. Besides various therapeutic effects, it has been found that when using essential oils, not only individual intolerance of the constituent components can occur, but also various adverse reactions. In addition to recommendations for use, particular adverse reactions and causes of general adverse reactions, a number of general recommendations have been identified when using essential oils. Such as, essential oils should be used with caution by the elderly, children under one year of age, and pregnant women. Essential oils should not be used orally without qualified specialist advice. Essential oils shouldn’t be diluted with water. Essential oils in high concentration are irritating in case of contact with mucous membranes. People who are prone to allergic reactions should use essential oils with caution. When using essential oils, a cutaneous or olfactory test should be performed. In the immediate vicinity of the eyes, essential oils should be applied carefully, avoiding direct contact. Essential oil bottles should be tightly closed after each use, as they are volatile, and kept out of the reach of children and pets. Essential oils are not only volatile but also flammable. On the basis of the identified features, an algorithm for pharmaceutical consulting when selling essential oils has been developed.
{"title":"FEATURES OF ESSENTIAL OILS REALIZATION IN A PHARMACY","authors":"G. V. Adamenko, D.A. Tsiomkina","doi":"10.22263/2312-4156.2021.5.84","DOIUrl":"https://doi.org/10.22263/2312-4156.2021.5.84","url":null,"abstract":"The objective of the work was to develop an algorithm for pharmaceutical consulting on the sale of essential oils. To achieve the set goal of the study, a content analysis of information array of data on aromatherapy products was carried out. The data obtained made it possible to systematize aromatic agents according to groups depending on their type and application (essential oils, base oils, cosmetic oils, massage oils, agents for baths, saunas and bathtubs). Having systematized the data of literature sources, we can draw a conclusion about such properties of essential oils as tonic, relaxing, soothing, anti-stress and others. Besides various therapeutic effects, it has been found that when using essential oils, not only individual intolerance of the constituent components can occur, but also various adverse reactions. In addition to recommendations for use, particular adverse reactions and causes of general adverse reactions, a number of general recommendations have been identified when using essential oils. Such as, essential oils should be used with caution by the elderly, children under one year of age, and pregnant women. Essential oils should not be used orally without qualified specialist advice. Essential oils shouldn’t be diluted with water. Essential oils in high concentration are irritating in case of contact with mucous membranes. People who are prone to allergic reactions should use essential oils with caution. When using essential oils, a cutaneous or olfactory test should be performed. In the immediate vicinity of the eyes, essential oils should be applied carefully, avoiding direct contact. Essential oil bottles should be tightly closed after each use, as they are volatile, and kept out of the reach of children and pets. Essential oils are not only volatile but also flammable. On the basis of the identified features, an algorithm for pharmaceutical consulting when selling essential oils has been developed.","PeriodicalId":23571,"journal":{"name":"Vestnik of Vitebsk State Medical University","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75474466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-11DOI: 10.22263/2312-4156.2021.5.96
L. Belyaeva, I. V. Lihetskaya
Objectives. To assess the problems that have arisen when using the elements of distance learning at the Chair of Pathologic Physiology of VSMU during an unfavorable epidemiological situation due to the spreading of Covid-19, and to assess the prospects for further using of distance learning based on the results of questioning students and teachers. Material and methods. The material of the research was the questionnaires of students (n=161) and teachers (n=35) of VSMU concerning the means and methods of organization, the advantages and disadvantages of using the elements of distance learning, in comparison with the traditional educational methods. Results. As a result of the study, it has been revealed that the majority of students and teachers (73 and 80%, respectively) adapted well to the conditions of a wider use of distance learning elements at the Chair of Pathologic Physiology; both students (59.1% of respondents) and teachers (68.8% of respondents) noted an increase in the working load on them during this period; most students and teachers prefer the traditional form of education with the elements of distance learning. The overwhelming majority of students are satisfied with the organization of the educational process at the Chair of Pathologic Physiology in the conditions of the wider use of distance learning elements and would like to increase the duration of videoconferences when using the Zoom platform. Conclusions. The experience of working in the distance mode has shown that the main problem of both participants of the educational process was the increase in the workload, and as to the students - also the need to clearly control their time and working day structure. If necessary, the expansion of the use of distance learning elements will allow to preserve the educational process at the Chair of Pathologic Physiology.
{"title":"PROBLEMS AND PROSPECTS FOR USING ELEMENTS OF DISTANCE LEARNING IN THE PROCESS OF TEACHING PATHOLOGIC PHYSIOLOGY: A VIEW OF STUDENTS AND TEACHERS","authors":"L. Belyaeva, I. V. Lihetskaya","doi":"10.22263/2312-4156.2021.5.96","DOIUrl":"https://doi.org/10.22263/2312-4156.2021.5.96","url":null,"abstract":"Objectives. To assess the problems that have arisen when using the elements of distance learning at the Chair of Pathologic Physiology of VSMU during an unfavorable epidemiological situation due to the spreading of Covid-19, and to assess the prospects for further using of distance learning based on the results of questioning students and teachers. Material and methods. The material of the research was the questionnaires of students (n=161) and teachers (n=35) of VSMU concerning the means and methods of organization, the advantages and disadvantages of using the elements of distance learning, in comparison with the traditional educational methods. Results. As a result of the study, it has been revealed that the majority of students and teachers (73 and 80%, respectively) adapted well to the conditions of a wider use of distance learning elements at the Chair of Pathologic Physiology; both students (59.1% of respondents) and teachers (68.8% of respondents) noted an increase in the working load on them during this period; most students and teachers prefer the traditional form of education with the elements of distance learning. The overwhelming majority of students are satisfied with the organization of the educational process at the Chair of Pathologic Physiology in the conditions of the wider use of distance learning elements and would like to increase the duration of videoconferences when using the Zoom platform. Conclusions. The experience of working in the distance mode has shown that the main problem of both participants of the educational process was the increase in the workload, and as to the students - also the need to clearly control their time and working day structure. If necessary, the expansion of the use of distance learning elements will allow to preserve the educational process at the Chair of Pathologic Physiology.","PeriodicalId":23571,"journal":{"name":"Vestnik of Vitebsk State Medical University","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83106839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-10-11DOI: 10.22263/2312-4156.2021.5.15
E. A. Dikareva, S. Pimanov
Ultrasound examination is used in all areas of modern medicine and occupies the leading positions in non-invasive instrumental diagnostics. Ultrasound is believed to be safe for patients. At the same time, there is a dangerous effect of ultrasound, manifested by bacterial and viral contamination of ultrasound equipment and the examined patients. Numerous studies have convincingly shown that ultrasound is dangerous in terms of iatrogenic contamination of a patient with bacterial, fungal and viral infections. Each ultrasound examination includes contact between the probe of the device and the patient’s skin, or his/her mucous membranes, or sterile tissues during intraoperative examinations. When the ultrasonic sensor comes into contact with the patient’s body, it may become contaminated with pathogenic and opportunistic microorganisms. It is also possible to contaminate the ultrasound equipment and the hands of a doctor who conducts this study. All this will subsequently contribute to the microorganisms transmission to other subjects being examined. Therefore, every patient should be considered as a potential source of pathogenic microorganisms and viruses. The purpose of the work was to analyze the literature data on bacterial and viral contamination during ultrasound examination.
{"title":"ULTRASOUND EXAMINATION AND THE RISK OF IATROGENIC INFECTIONS DEVELOPMENT","authors":"E. A. Dikareva, S. Pimanov","doi":"10.22263/2312-4156.2021.5.15","DOIUrl":"https://doi.org/10.22263/2312-4156.2021.5.15","url":null,"abstract":"Ultrasound examination is used in all areas of modern medicine and occupies the leading positions in non-invasive instrumental diagnostics. Ultrasound is believed to be safe for patients. At the same time, there is a dangerous effect of ultrasound, manifested by bacterial and viral contamination of ultrasound equipment and the examined patients. Numerous studies have convincingly shown that ultrasound is dangerous in terms of iatrogenic contamination of a patient with bacterial, fungal and viral infections. Each ultrasound examination includes contact between the probe of the device and the patient’s skin, or his/her mucous membranes, or sterile tissues during intraoperative examinations. When the ultrasonic sensor comes into contact with the patient’s body, it may become contaminated with pathogenic and opportunistic microorganisms. It is also possible to contaminate the ultrasound equipment and the hands of a doctor who conducts this study. All this will subsequently contribute to the microorganisms transmission to other subjects being examined. Therefore, every patient should be considered as a potential source of pathogenic microorganisms and viruses. The purpose of the work was to analyze the literature data on bacterial and viral contamination during ultrasound examination.","PeriodicalId":23571,"journal":{"name":"Vestnik of Vitebsk State Medical University","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87365765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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