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Veterinary anaesthesia and analgesia最新文献

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The impact of using pain scales by untrained students on the decision to provide analgesia to multiple species 未经培训的学生使用疼痛量表对决定为多个物种提供镇痛的影响。
IF 1.4 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-06-27 DOI: 10.1016/j.vaa.2024.06.010

Objective

To evaluate if students without training assess pain similarly to an expert, and to compare indications for analgesic intervention based on student opinions versus scale scoring.

Study design

Prospective, blind, randomized, cross-sectional study.

Animals

Video recordings of a bull, horse, cat, pig and sheep.

Methods

First-year veterinary medicine students assessed one video of a horse (n = 44) and one video of a bull (n = 39). Third-year veterinary medicine students assessed one video of a cat (n = 23) and one video of a pig (n = 21). Fourth-year animal science students (n = 16) assessed one video of a sheep. The species assessed by different student classes were determined randomly. Students were unaware of animal history or existing pain assessment and decided whether they would provide analgesia according to their opinion. They then scored each video using species-specific validated pain scales. Scores were compared with those of a board-certified anesthesiologist (expert). Chi-square test was used to compare students and expert.

Results

Students underestimated the expert's score by 8–20%, except for the horse. There was no difference between the analgesic indication according to the assessment of the expert (143/143, 100%) and students (141/143, 98.6%) considering the defined analgesic intervention threshold for each scale (p = 0.478). The indication for analgesic intervention according to students’ opinion (116/143, 81.1%) was lower than that according to their scale scores (141/143, 98.6%) (p < 0.0001).

Conclusions and clinical relevance

Students tended to underestimate pain; however, they detected pain that requires analgesic intervention in animals similarly to an expert. The use of scales optimized the indication for providing analgesia when animals were experiencing pain that required analgesic intervention.

目的:评估未经培训的学生对疼痛的评估是否与专家相似,并比较学生意见与量表评分对镇痛干预的适应症:评估未经培训的学生对疼痛的评估是否与专家相似,并比较根据学生意见和量表评分进行镇痛干预的适应症:研究设计:前瞻性、盲法、随机、横断面研究:动物:牛、马、猫、猪和羊的视频录像:兽医学一年级学生评估了一段马的视频(44 人)和一段公牛的视频(39 人)。兽医学三年级学生评估了一段猫(n = 23)和一段猪(n = 21)的视频。动物科学四年级学生(16 人)评估了一段羊的视频。不同班级学生评估的物种是随机决定的。学生们不了解动物的病史或现有的疼痛评估方法,并根据自己的意见决定是否提供镇痛。然后,他们使用针对特定物种的有效疼痛量表对每段视频进行评分。评分结果将与一位经委员会认证的麻醉师(专家)的评分结果进行比较。结果显示,学生低估了专家的评分:结果:除了马以外,学生低估了专家评分的 8-20%。考虑到每个量表定义的镇痛干预阈值,根据专家(143/143,100%)和学生(141/143,98.6%)的评估,镇痛指征之间没有差异(p = 0.478)。学生认为的镇痛干预指征(116/143,81.1%)低于量表评分(141/143,98.6%)(p < 0.0001):学生倾向于低估疼痛,但他们对需要镇痛干预的动物疼痛的检测结果与专家相似。量表的使用优化了在动物出现需要镇痛干预的疼痛时提供镇痛的指征。
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引用次数: 0
Comparison of cardiopulmonary effects of propofol, ketamine–propofol and isoflurane anesthesia in the domestic chicken (Gallus gallus domesticus) 比较异丙酚、氯胺酮-异丙酚和异氟醚麻醉对家鸡心肺功能的影响。
IF 1.4 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-06-18 DOI: 10.1016/j.vaa.2024.06.005

Objective

To compare the effects of propofol, ketamine–propofol and isoflurane, at similar anesthetic depth, on cardiopulmonary variables in unpremedictated chickens.

Study design

Prospective, randomized, crossover experimental trial.

Animals

A total of 10 male Leghorn domestic chickens, aged 3 months and body mass 1.4–2.0 kg.

Methods

Birds were randomly assigned to each of three anesthetic protocols, 7 days apart: intravenous propofol, intravenous ketamine–propofol or isoflurane. Anesthesia was induced (indicated by loss of righting reflex and tracheal intubation) and maintained with propofol (10 mg kg–1 minute–1, then 1.1 mg kg–1 minute–1), ketamine–propofol (5 mg mL–1 ketamine and 5 mg mL–1 propofol combined; 10 mg kg–1 minute–1, then 1.1 mg kg–1 minute–1) or isoflurane [5% vaporizer setting initially, then end-tidal concentration (Fe′Iso) of 2%] for 65 minutes. Anesthesia was maintained at a similar anesthetic depth based upon positive or negative responses to toe pinch. Heart rate (HR), respiratory rate (fR), noninvasive arterial blood pressure and arterial blood gases were measured during anesthesia. Propofol or ketamine–propofol infusion rates and Fe′Iso required to prevent movement in response to a noxious stimulus and recovery times were recorded.

Results

Anesthesia induction dose was 9.0 ± 0.8 (mean ± SD) and 12.2 ± 0.3 mg kg–1 for propofol and ketamine–propofol, respectively. Propofol and ketamine–propofol infusion rates and Fe′Iso required to prevent movement in response to the noxious stimulus were 0.88 ± 0.14 mg kg–1 minute–1, 0.92 ± 0.14 mg kg–1 minute–1 and 1.45 ± 0.28%, respectively. Cardiopulmonary variables remained clinically acceptable, but ketamine–propofol was associated with a significantly higher HR (p = 0.0001) and lower fR (p = 0.0001). Time to extubation did not differ among treatments.

Conclusions and clinical relevance

Cardiovascular and respiratory variables were maintained within normal ranges in all treatments. Coadministration of ketamine with propofol significantly reduced the induction and maintenance dose of propofol.

研究目的比较丙泊酚、氯胺酮-丙泊酚和异氟醚在相似麻醉深度下对未受麻醉鸡心肺变量的影响:研究设计:前瞻性、随机、交叉实验试验:共 10 只雄性莱格霍恩家鸡,年龄 3 个月,体重 1.4-2.0 公斤:鸟类被随机分配到三种麻醉方案中,每种方案间隔 7 天:静脉注射异丙酚、静脉注射氯胺酮-异丙酚或异氟醚。使用丙泊酚(10 毫克/千克-1 分钟,然后 1.1 毫克/千克-1 分钟)、氯胺酮-丙泊酚(5 毫克/毫升-1 氯胺酮和 5 毫克/毫升-1 丙泊酚混合;10 毫克/千克-1 分钟,然后 1.1 毫克/千克-1 分钟)或异氟烷[初始设定为 5%,然后潮气末浓度(Fe'Iso)为 2%]诱导麻醉(以右侧反射消失和气管插管为标志)并维持 65 分钟。根据捏脚趾的阳性或阴性反应,将麻醉维持在相似的麻醉深度。麻醉期间测量了心率(HR)、呼吸频率(fR)、无创动脉血压和动脉血气。记录了丙泊酚或氯胺酮-丙泊酚的输注率、防止对有害刺激做出反应所需的Fe'Iso以及恢复时间:丙泊酚和氯胺酮-丙泊酚的麻醉诱导剂量分别为 9.0 ± 0.8(平均值 ± SD)和 12.2 ± 0.3 mg kg-1。丙泊酚和氯胺酮-丙泊酚的输注率和防止对有害刺激做出反应的运动所需的 Fe'Iso 分别为 0.88 ± 0.14 mg kg-1 minute-1、0.92 ± 0.14 mg kg-1 minute-1 和 1.45 ± 0.28%。心肺变量在临床上仍可接受,但氯胺酮-丙泊酚与显著较高的心率(p = 0.0001)和较低的 fR(p = 0.0001)相关。不同治疗方法的拔管时间没有差异:所有治疗方法的心血管和呼吸变量均保持在正常范围内。氯胺酮与异丙酚同时使用可显著减少异丙酚的诱导和维持剂量。
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引用次数: 0
Pharmacokinetic profile and physiological effects of oral and compounded intravenous gabapentin in goats 山羊口服和复方静脉注射加巴喷丁的药代动力学特征和生理效应。
IF 1.4 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-06-18 DOI: 10.1016/j.vaa.2024.06.006

Objective

To determine the pharmacokinetics and physiological effects following oral and intravenous (IV) administration of gabapentin in goats.

Study design

Prospective, crossover study with a 3 week washout period between treatments.

Animals

A total of eight healthy, client-owned, female goats.

Methods

Gabapentin (10 mg kg–1) was administered to goats either orally or IV. Gabapentin concentrations were measured in serum samples collected 0–96 hours post-administration using liquid chromatography–quadrupole time-of-flight mass spectrometry. Heart rate, respiratory rate, blood pressure and temperature were recorded before and throughout the study. Correlations of the mean serum concentrations of gabapentin to those of each physiological parameter were determined using the Pearson method.

Results

The mean and standard deviation of oral bioavailability for gabapentin was 60.9 ± 11.2%. Maximum serum concentration of gabapentin was lower following oral (1.19 ± 0.29 μg mL–1) than after IV administration (59.76 ± 14.38 μg mL–1, p < 0.0001). Half-lives were longer following PO (8.18 ± 0.57 hours) than after IV administration (1.79 ± 0.06 hours, p < 0.0001). Time to maximum concentration was 6.86 ± 2.27 hours following oral administration. Heart rate was inversely correlated with serum gabapentin concentrations. Slight ataxia was observed in three animals, and one became recumbent following IV gabapentin.

Conclusions and clinical relevance

Gabapentin is well-absorbed following oral administration to goats but yielded significantly lower serum concentrations than the IV route. The longer half-life of gabapentin following oral than after IV administration may result from prolonged absorption throughout the caprine gastrointestinal tract. IV gabapentin may cause slight ataxia in some goats.

目的:确定山羊口服和静脉注射加巴喷丁后的药代动力学和生理效应:确定山羊口服和静脉注射加巴喷丁后的药代动力学和生理效应:研究设计:前瞻性交叉研究,两次治疗之间有 3 周的冲洗期:动物:共八只健康、客户饲养的雌性山羊:给山羊口服或静脉注射加巴喷丁(10 毫克/千克)。使用液相色谱-四极杆飞行时间质谱法测量给药后 0-96 小时采集的血清样本中的加巴喷丁浓度。研究之前和整个过程中都记录了心率、呼吸频率、血压和体温。用皮尔逊法测定了加巴喷丁平均血清浓度与各生理参数的相关性:结果:加巴喷丁口服生物利用度的平均值和标准偏差为 60.9 ± 11.2%。加巴喷丁口服后的最大血清浓度(1.19 ± 0.29 μg mL-1)低于静脉注射后(59.76 ± 14.38 μg mL-1,p < 0.0001)。口服后的半衰期(8.18 ± 0.57 小时)长于静脉注射后(1.79 ± 0.06 小时,p < 0.0001)。口服后达到最大浓度的时间为 6.86 ± 2.27 小时。心率与血清中的加巴喷丁浓度成反比。三只动物出现轻微共济失调,其中一只动物在静脉注射加巴喷丁后出现休克:山羊口服加巴喷丁后吸收良好,但血清浓度明显低于静脉注射。加巴喷丁口服后的半衰期长于静脉注射,这可能是由于山羊胃肠道的吸收时间较长。静脉注射加巴喷丁可能会导致某些山羊出现轻微共济失调。
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引用次数: 0
Perceived impact of the COVID-19 pandemic on residency training in American College of Veterinary Anesthesia and Analgesia programs in North America: a quantitative survey COVID-19大流行对北美美国兽医麻醉与镇痛学院住院医师培训的影响:一项定量调查。
IF 1.4 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-06-18 DOI: 10.1016/j.vaa.2024.06.007

Objective

To characterize the extent of the impact of the COVID-19 pandemic on aspects of the anesthesia residency experience from the perspective of American College of Veterinary Anesthesia and Analgesia (ACVAA) mentors and trainees. This includes the residency interview process, didactic training and availability and variety of clinical cases for resident learning.

Study design

Cross-sectional, online, anonymous voluntary survey.

Sample population

A total of 58 respondents, representing 30 residency program mentors and 28 residents.

Methods

Surveys were distributed by email to 94 residency program mentors and 70 residents, representing programs and residents registered with the ACVAA during the years of 2019–2021. Anonymous links to an online survey were provided via a link embedded in the email. Questions included perceived impacts (–5 to +5 scale) on didactic and clinical training, case distribution, workload, residency application and selection process, and mental health. Responses were summarized with descriptive statistics [median (IQR) or mean ± SD].

Results

The overall survey response rate was 31.9% (30/94) and 40.0% (28/70) for resident program mentors and residents, respectively. There was a negative perceived impact on overall residency training reported: –1.0 (IQR –2.0 to 0) for program mentors and –1.5 ± 1.5 for residents. The reported perceived impact of travel limitations on case log completion was –2.0 (IQR –4.0 to –1.0) for program mentors and –2.4 ± 2.0 for residents. Program mentors and residents had incongruent feelings on the impact of the pandemic on work hours, with residents reporting a perceived increase in work hours [+2.1 ± 2.1 versus 0 (IQR –1.0 to 0)].

Conclusions

Residency program mentors and residents generally agreed that the COVID-19 pandemic had negatively impacted multiple aspects of residency interview and training process. A broader, objective analysis of veterinary anesthesia training programs is required to fully elucidate the scale of the impact on veterinary anesthesia training.

目的:从美国兽医麻醉与镇痛学院(American College of Veterinary Anesthesia and Analgesia, ACVAA)导师和受训者的角度,描述 COVID-19 大流行对麻醉住院医师实习经历各方面的影响程度。研究设计:研究设计:横断面、在线、匿名自愿调查:共有 58 名受访者,分别代表 30 名住院医师培训项目导师和 28 名住院医师:通过电子邮件向 94 名住院医师培训项目导师和 70 名住院医师发放了调查问卷,他们代表了 2019-2021 年期间在 ACVAA 注册的项目和住院医师。电子邮件中嵌入了在线调查的匿名链接。问题包括对教学和临床培训、病例分配、工作量、住院医师申请和遴选过程以及心理健康的影响(-5 到 +5)。调查结果以描述性统计[中位数(IQR)或平均值±标准差]进行总结:住院医师项目导师和住院医师的总体调查回复率分别为 31.9%(30/94)和 40.0%(28/70)。据报告,住院医师培训总体上受到了负面影响:项目导师为-1.0(IQR -2.0至0),住院医师为-1.5 ± 1.5。据报告,项目导师认为旅行限制对病例记录完成的影响为-2.0(IQR -4.0至-1.0),住院医师为-2.4 ± 2.0。在大流行病对工作时间的影响方面,项目导师和住院医师的感受不一致,住院医师认为工作时间增加了[+2.1 ± 2.1 对 0 (IQR -1.0 to 0)]:住院医师项目导师和住院医师普遍认为,COVID-19大流行对住院医师面试和培训过程的多个方面产生了负面影响。需要对兽医麻醉培训项目进行更广泛、更客观的分析,以充分阐明对兽医麻醉培训的影响程度。
{"title":"Perceived impact of the COVID-19 pandemic on residency training in American College of Veterinary Anesthesia and Analgesia programs in North America: a quantitative survey","authors":"","doi":"10.1016/j.vaa.2024.06.007","DOIUrl":"10.1016/j.vaa.2024.06.007","url":null,"abstract":"<div><h3>Objective</h3><p>To characterize the extent of the impact of the COVID-19 pandemic on aspects of the anesthesia residency experience from the perspective of American College of Veterinary Anesthesia and Analgesia (ACVAA) mentors and trainees. This includes the residency interview process, didactic training and availability and variety of clinical cases for resident learning.</p></div><div><h3>Study design</h3><p>Cross-sectional, online, anonymous voluntary survey.</p></div><div><h3>Sample population</h3><p>A total of 58 respondents, representing 30 residency program mentors and 28 residents.</p></div><div><h3>Methods</h3><p>Surveys were distributed by email to 94 residency program mentors and 70 residents, representing programs and residents registered with the ACVAA during the years of 2019–2021. Anonymous links to an online survey were provided via a link embedded in the email. Questions included perceived impacts (–5 to +5 scale) on didactic and clinical training, case distribution, workload, residency application and selection process, and mental health<span>. Responses were summarized with descriptive statistics [median (IQR) or mean ± SD].</span></p></div><div><h3>Results</h3><p>The overall survey response rate was 31.9% (30/94) and 40.0% (28/70) for resident program mentors and residents, respectively. There was a negative perceived impact on overall residency training reported: –1.0 (IQR –2.0 to 0) for program mentors and –1.5 ± 1.5 for residents. The reported perceived impact of travel limitations on case log completion was –2.0 (IQR –4.0 to –1.0) for program mentors and –2.4 ± 2.0 for residents. Program mentors and residents had incongruent feelings on the impact of the pandemic on work hours, with residents reporting a perceived increase in work hours [+2.1 ± 2.1 <em>versus</em> 0 (IQR –1.0 to 0)].</p></div><div><h3>Conclusions</h3><p>Residency program mentors and residents generally agreed that the COVID-19 pandemic had negatively impacted multiple aspects of residency interview and training process. A broader, objective analysis of veterinary anesthesia training programs is required to fully elucidate the scale of the impact on veterinary anesthesia training.</p></div>","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retrospective study of the changes in dynamic compliance and ventilation/perfusion mismatch following salbutamol inhalation in hypoxaemic mechanically ventilated anaesthetized horses 低氧血症机械通气麻醉马吸入沙丁胺醇后动态顺应性和通气/灌注失配变化的回顾性研究。
IF 1.4 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-06-18 DOI: 10.1016/j.vaa.2024.06.008

Objective

To study the changes in dynamic compliance (Cdyn), ventilation/perfusion (V˙/ Q˙) mismatch and haemodynamic variables in hypoxaemic anaesthetized horses whose PaO2 increased following salbutamol inhalation.

Study design

Retrospective, clinical, cohort study.

Animals

A group of 73 client-owned horses treated with salbutamol when PaO2 <100 mmHg (13.3 kPa) during anaesthesia.

Methods

Horses were divided into two groups: responders (R), where PaO2 after salbutamol ≥1.2 PaO2 before treatment (i.e. ≥20% increase), and non-responders (NR), where PaO2 after salbutamol <1.2 PaO2 before treatment. Demographic data and intraoperative variables before treatment were compared between R and NR. Cdyn, arterial to end-tidal carbon dioxide difference [P(a-E´)CO2], estimated ratio of dead space to tidal volume (est.VD/VT), estimated shunt fraction (F-shunt), heart rate, systolic, mean and diastolic arterial pressure and dobutamine requirements were compared before and after treatment within R and NR. For each variable, the difference (Δ) between values pre- and posttreatment was calculated and compared between groups R and NR. Numerical data were compared using univariate or bivariate analysis and categorical data were compared using chi-square test; p < 0.05.

Results

Of the 73 horses 50 were classified as R while 23 horses were classified as NR. There was no statistical difference between R and NR for demographic data or initial intraoperative variables except for body weight [R: 531 (170–715) kg, NR: 540 (420–914) kg]. While salbutamol did not alter Cdyn in either group, it significantly decreased P(a-E´)CO2, est.VD/VT and F-shunt in R only. ΔP(a-E´)CO2, Δest.VD/VT and ΔF-shunt were significantly greater in R (−17.8%, −19.0% and −24.1%, respectively) than in NR (11.5%, 6.6% and −0.3%, respectively).

Conclusions and clinical relevance

In hypoxaemic anaesthetized horses responding to inhaled salbutamol by a ≥1.2 increase in PaO2 no change in Cdyn was detected, but indicators of V˙/ Q˙ mismatch improved.

目的研究低氧血症麻醉马的动态顺应性(Cdyn)、通气/灌注(V˙/ Q˙)不匹配和血流动力学变量的变化:研究设计:回顾性临床队列研究:方法:将马匹分为两组:沙丁胺醇吸入后 PaO2 ≥治疗前 PaO2 1.2(即增加≥20%)的应答者(R)和沙丁胺醇吸入后 PaO2 ≥治疗前 PaO2 2 的非应答者(NR)。对 R 和 NR 治疗前的人口统计学数据和术中变量进行比较。对 R 和 NR 治疗前后的 Cdyn、动脉与潮气末二氧化碳差[P(a-E´)CO2]、估计死腔与潮气量比值(est.VD/VT)、估计分流分数(F-shunt)、心率、收缩压、平均动脉压和舒张压以及多巴酚丁胺需求量进行了比较。对于每个变量,计算治疗前后的差值 (Δ),并在 R 组和 NR 组之间进行比较。数字数据采用单变量或双变量分析进行比较,分类数据采用卡方检验进行比较;P < 0.05:在 73 匹马中,50 匹被归类为 R 型,23 匹被归类为 NR 型。除了体重[R:531(170-715)公斤,NR:540(420-914)公斤]外,R和NR在人口统计学数据或术中初始变量方面没有统计学差异。虽然沙丁胺醇没有改变两组患者的 Cdyn,但仅 R 组患者的 P(a-E´)CO2、EST.VD/VT 和 F-shunt 显著降低。R组的ΔP(a-E´)CO2、Δest.VD/VT和ΔF分流分别为-17.8%、-19.0%和-24.1%,明显高于NR组(分别为11.5%、6.6%和-0.3%):在吸入沙丁胺醇后PaO2增加≥1.2的低氧血症麻醉马中,未检测到Cdyn发生变化,但V˙/ Q˙不匹配指标有所改善。
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引用次数: 0
Anaesthetic practices and attitudes to patient safety in a sample of Australian veterinary practices 澳大利亚兽医诊所的麻醉实践和对患者安全的态度。
IF 1.4 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-06-17 DOI: 10.1016/j.vaa.2024.06.004

Objective

To survey anaesthetic practices and attitudes towards veterinary patient safety in Australia.

Study design

This was a cross-sectional sample population from Australian veterinary practices, including first opinion small animal, mixed animal and referral small animal practices. The survey included practices’ anaesthetic management, monitoring equipment and topics regarding patient safety.

Results

Responses were obtained from 310/1700 (18%) veterinary practices, with 208 respondents from small animal practices (67%), 71 mixed animal practices (23%) and 31 referral small animal centres (10%). Overall, 61% of respondents reported always having a dedicated staff member monitoring the anaesthetic, who was most commonly a certified veterinary nurse (89%). In 22% of the practices, some of the staff monitoring an anaesthetic did not have any qualification. Completion of anaesthetic plans for each animal prior to an anaesthetic was reported by 24.5% of respondents and labelling of syringes was completed in 80% of practices. Pulse oximetry (98%) and temperature (88%) were the most common clinical variables monitored. The use of capnography (46%) or an electrocardiogram (48%) was also reported by the respondents. Emergency drugs, airway and ventilation equipment are available in 96%, 88% and 59% of practices, respectively. A defibrillator was available in 11% of practices with only 54% respondents being confident in using it. Of the respondents 60% were aware of anaesthesia safety interventions and clinical guidelines regarding patient safety during anaesthesia.

Conclusions and clinical relevance

Despite practices showing a relative improvement over the years in the standard of anaesthesia care, most of them are still not meeting international guidelines. Areas where changes could lead to improved safety practices could include: a trained person dedicated to monitor anaesthesia, pain scoring evaluation in patients recovering from anaesthesia, an increased use of standardised handover checklists, record keeping and an increase in open discussion of adverse events by the veterinary team.

研究目的调查澳大利亚的麻醉实践和对兽医患者安全的态度:这是一项横断面抽样调查,调查对象来自澳大利亚的兽医诊所,包括首诊小动物诊所、混合动物诊所和转诊小动物诊所。调查内容包括诊所的麻醉管理、监测设备和有关患者安全的话题:310/1700(18%)家兽医诊所做出了回复,其中208家受访者来自小动物诊所(67%),71家混合动物诊所(23%)和31家转诊小动物中心(10%)。总体而言,61%的受访者称一直有专职人员负责监控麻醉过程,其中最常见的是注册兽医护士(89%)。在22%的诊疗机构中,一些负责监测麻醉的工作人员没有任何资质。24.5%的受访者报告在麻醉前为每只动物完成了麻醉计划,80%的诊所完成了注射器的贴标工作。脉搏氧饱和度(98%)和体温(88%)是最常见的临床监测变量。受访者还报告使用了通气造影(46%)或心电图(48%)。分别有 96%、88% 和 59%的医疗机构配备了急救药物、气道和通气设备。11%的医疗机构有除颤器,但只有54%的受访者有信心使用。60%的受访者了解有关麻醉期间患者安全的麻醉安全干预措施和临床指南:尽管多年来麻醉护理标准相对有所提高,但大多数麻醉实践仍未达到国际指南的要求。可改善麻醉安全的领域包括:由受过培训的人员专门负责监测麻醉、对麻醉后恢复期的患者进行疼痛评分评估、更多地使用标准化交接清单、保存记录以及兽医团队更多地公开讨论不良事件。
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引用次数: 0
Propofol-sparing and hemodynamic effects of guaifenesin in sheep 胍乙啶在绵羊体内的丙泊酚稀释作用和血液动力学效应
IF 1.4 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-06-11 DOI: 10.1016/j.vaa.2024.06.003

Objective

To evaluate the propofol-sparing and hemodynamic effects of guaifenesin administered for co-induction of anesthesia in sheep.

Study design

Prospective, blinded, two-way crossover experimental study.

Animals

Thirteen healthy adult female sheep.

Methods

Anesthesia was induced without premedication with intravenous (IV) guaifenesin 5% at 100 mg kg–1 (GGE) or an equivalent volume of physiologic saline (SAL), followed by IV propofol at a controlled rate (1 mg kg–1 min–1). Heart rate (HR), respiratory rate and oscillometric noninvasive arterial blood pressure (NIBP) were recorded at baseline after co-induction administration, following endotracheal intubation and every 2 minutes thereafter for 10 minutes. Propofol doses required to achieve intubation after each co-induction treatment were compared by independent Student’s t-test. Values of p < 0.05 were considered statistically significant.

Results

The propofol dose required (mean ± standard deviation) to achieve intubation was significantly lower (p = 0.001) in the GGE treatment (3.40 ± 0.74 mg kg–1) than in the SAL treatment (5.94 ± 1.09 mg kg–1). HR was increased after anesthetic induction compared with baseline in both treatments. HR was generally lower in the GGE treatment than in the SAL treatment. NIBP did not vary between GGE and SAL treatments.

Conclusions and clinical relevance

Guaifenesin, when administered as a co-induction agent with propofol in sheep, reduces propofol dose requirements and maintains hemodynamic variables within a clinically acceptable range.

研究设计前瞻性、盲法、双向交叉实验研究。动物 13 只健康成年雌性绵羊。研究方法在不预先用药的情况下,静脉注射 5%、100 毫克/千克的愈创木酚(GGE)或等量生理盐水(SAL)进行麻醉诱导,然后以可控速率(1 毫克/千克/分钟-1)静脉注射异丙酚。心率(HR)、呼吸频率和示波无创动脉血压(NIBP)在联合诱导给药后的基线、气管插管后以及之后每 2 分钟记录一次,持续 10 分钟。通过独立的学生 t 检验比较了每种联合诱导治疗后实现插管所需的丙泊酚剂量。结果 GGE 处理(3.40 ± 0.74 mg kg-1)与 SAL 处理(5.94 ± 1.09 mg kg-1)相比,实现插管所需的丙泊酚剂量(平均值 ± 标准偏差)显著降低(p = 0.001)。与基线相比,两种治疗方法的麻醉诱导后心率都有所增加。GGE 处理的心率普遍低于 SAL 处理。结论和临床意义胍乙啶作为异丙酚的共同诱导剂用于绵羊时,可减少异丙酚的剂量需求,并将血液动力学变量维持在临床可接受的范围内。
{"title":"Propofol-sparing and hemodynamic effects of guaifenesin in sheep","authors":"","doi":"10.1016/j.vaa.2024.06.003","DOIUrl":"10.1016/j.vaa.2024.06.003","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate the propofol-sparing and hemodynamic effects of guaifenesin administered for co-induction of anesthesia in sheep.</p></div><div><h3>Study design</h3><p>Prospective, blinded, two-way crossover experimental study.</p></div><div><h3>Animals</h3><p>Thirteen healthy adult female sheep.</p></div><div><h3>Methods</h3><p>Anesthesia was induced without premedication with intravenous (IV) guaifenesin 5% at 100 mg kg<sup>–1</sup> (GGE) or an equivalent volume of physiologic saline (SAL), followed by IV propofol at a controlled rate (1 mg kg<sup>–1</sup> min<sup>–1</sup>). Heart rate (HR), respiratory rate and oscillometric noninvasive arterial blood pressure (NIBP) were recorded at baseline after co-induction administration, following endotracheal intubation and every 2 minutes thereafter for 10 minutes. Propofol doses required to achieve intubation after each co-induction treatment were compared by independent Student’s <em>t</em>-test. Values of <em>p</em> &lt; 0.05 were considered statistically significant.</p></div><div><h3>Results</h3><p>The propofol dose required (mean ± standard deviation) to achieve intubation was significantly lower (<em>p</em> = 0.001) in the GGE treatment (3.40 ± 0.74 mg kg<sup>–1</sup>) than in the SAL treatment (5.94 ± 1.09 mg kg<sup>–1</sup>). HR was increased after anesthetic induction compared with baseline in both treatments. HR was generally lower in the GGE treatment than in the SAL treatment. NIBP did not vary between GGE and SAL treatments.</p></div><div><h3>Conclusions and clinical relevance</h3><p>Guaifenesin, when administered as a co-induction agent with propofol in sheep, reduces propofol dose requirements and maintains hemodynamic variables within a clinically acceptable range.</p></div>","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1467298724001144/pdfft?md5=919c3fae40d18b715f969968e560fd35&pid=1-s2.0-S1467298724001144-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141408678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of body position on transesophageal atrial pacing in dogs 狗的体位对经食道心房起搏的影响
IF 1.4 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-06-09 DOI: 10.1016/j.vaa.2024.06.001

Objective

To evaluate the effect of body position on transesophageal atrial pacing (TEAP) in dogs.

Study design

Prospective, experimental trial.

Animals

A total of eight mixed-breed dogs, median body mass 25 kg (range 11–31 kg).

Methods

TEAP was performed using a 6 Fr (2 mm) pacing catheter introduced transorally and positioned in the lower esophagus in left lateral recumbency. The catheter was withdrawn in 5 mm increments until successful TEAP. The minimum pacing threshold (MPT) was determined at each 5 mm increment until atrial capture could not be achieved at a maximal pulse amplitude of 40 mA. The zone of capture (ZOC) was the total distance over which TEAP was achieved. The same process was repeated in right lateral, ventral and dorsal recumbency. A linear mixed model was used to assess the impact of body position on TEAP and ZOC.

Results

TEAP was achieved in all body positions. There was significant random effect of individual dogs on ZOC (p = 0.048) but not on MPT (p = 0.109). MPT was 11.56 ± 8.65 mA (mean ± SD), 8.43 ± 2.29 mA, 10.63 ± 6.91 mA and 10 ± 7.44 mA for dorsal, left and right lateral, and ventral recumbency, respectively. ZOC was 5.12 ± 2.08 cm, 6.35 ± 2.41 cm, 5.94 ± 3.23 cm and 5.31 ± 2.2 cm for dorsal, left lateral and right lateral, and ventral recumbency, respectively. Neither ZOC (p = 0.363) nor MPT (p = 0.716) varied significantly between body positions.

Conclusions and clinical relevance

TEAP can be performed successfully in all body positions in dogs. Body position did not significantly influence MPT or ZOC values for TEAP. Further studies are needed to compare the efficacy of TEAP with the efficacy of standard pharmacological therapy for management of bradycardia during general anesthesia in dogs.

研究设计前瞻性、实验性试验。动物共 8 只混种犬,中位体重 25 千克(11-31 千克不等)。方法在左侧卧位时,使用 6 Fr(2 毫米)的起搏导管经口导入并定位在食道下段,进行经食道心房起搏(TEAP)。导管以 5 毫米为单位抽出,直到 TEAP 成功为止。在最大脉冲振幅为 40 mA 时无法捕获心房之前,每 5 mm 增量测定最小起搏阈值 (MPT)。捕获区 (ZOC) 是实现 TEAP 的总距离。在右侧卧位、腹侧卧位和背侧卧位时重复同样的过程。采用线性混合模型评估体位对 TEAP 和 ZOC 的影响。个体犬对 ZOC 有明显的随机影响(p = 0.048),但对 MPT 没有明显影响(p = 0.109)。背卧位、左右侧卧位和腹侧卧位的 MPT 分别为 11.56 ± 8.65 mA(平均值 ± SD)、8.43 ± 2.29 mA、10.63 ± 6.91 mA 和 10 ± 7.44 mA。背侧、左外侧、右外侧和腹侧腰位的 ZOC 分别为 5.12 ± 2.08 厘米、6.35 ± 2.41 厘米、5.94 ± 3.23 厘米和 5.31 ± 2.2 厘米。不同体位的 ZOC(p = 0.363)和 MPT(p = 0.716)均无显著差异。体位对 TEAP 的 MPT 或 ZOC 值没有明显影响。还需要进一步研究,比较 TEAP 与标准药物疗法在治疗犬全身麻醉期间心动过缓方面的疗效。
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引用次数: 0
Accidental epidural morphine overdose in a cat 一只猫意外硬膜外注射吗啡过量
IF 1.4 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-06-08 DOI: 10.1016/j.vaa.2024.06.002
{"title":"Accidental epidural morphine overdose in a cat","authors":"","doi":"10.1016/j.vaa.2024.06.002","DOIUrl":"10.1016/j.vaa.2024.06.002","url":null,"abstract":"","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141393850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nasotracheal intubation in a goat with a congenital mandibular malformation 为患有先天性下颌骨畸形的山羊进行气管插管
IF 1.4 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-06-03 DOI: 10.1016/j.vaa.2024.05.012
{"title":"Nasotracheal intubation in a goat with a congenital mandibular malformation","authors":"","doi":"10.1016/j.vaa.2024.05.012","DOIUrl":"10.1016/j.vaa.2024.05.012","url":null,"abstract":"","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141281917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Veterinary anaesthesia and analgesia
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