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Veterinary anaesthesia and analgesia最新文献

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A comparative analysis of opioid-free and opioid-sparing anaesthesia techniques for laparoscopic ovariectomy in healthy dogs 健康犬腹腔镜卵巢切除术中无阿片和有阿片麻醉技术的比较分析。
IF 1.7 2区 农林科学 Q1 Veterinary Pub Date : 2024-02-24 DOI: 10.1016/j.vaa.2024.02.005
Eleonora Lazzarini , Daniela Gioeni , Giulia Del Prete , Giulia Sala , Matteo Baio , Alessandra M. Carotenuto

Objective

To compare the perioperative analgesic effects of an opioid-free (OFA) and an opioid-sparing (OSA) anaesthetic protocol in dogs undergoing laparoscopic ovariectomy.

Study design

Prospective, randomized, blinded, clinical trial.

Animals

A group of 28 client-owned dogs.

Methods

Dogs were allocated to one of two groups. The OFA group was administered intramuscular (IM) dexmedetomidine 5 μg kg–1 and ketamine 1 mg kg–1, followed by two intraoperative constant rate infusions (CRIs) of dexmedetomidine (3 μg kg–1 hour–1) and lidocaine (1 mg kg–1 loading dose, 2 mg kg–1 hour–1). The OSA group was administered IM dexmedetomidine 5 μg kg–1, ketamine 1 mg kg–1 and methadone 0.2 mg kg–1, followed by two intraoperative saline CRIs. In both groups, anaesthesia was induced with intravenous (IV) propofol 2 mg kg–1 and diazepam 0.2 mg kg–1 and maintained with isoflurane. Rescue dexmedetomidine (0.5 μg kg–1) was administered IV if there was a 20% increase in cardiovascular variables compared with pre-stimulation values. Ketorolac (0.5 mg kg–1) was administered IV when the surgery ended. Postoperative analgesia was evaluated using the Short Form-Glasgow Composite Measure Pain Scale and methadone (0.2 mg kg–1) was administered IM if the pain score was ≥ 6/24. Statistical analysis included mixed analysis of variance, Chi-square test and Mann–Whitney U test.

Results

There were no significant differences in the intraoperative monitored variables between groups. The OFA group showed a significantly lower intraoperative rescue analgesia requirement (p = 0.016) and lower postoperative pain scores at 3 (p =0.001) and 6 (p < 0.001) hours. No dogs were administered rescue methadone postoperatively.

Conclusions and clinical relevance

Although both groups achieved acceptable postoperative pain scores with no need for further intervention, the analgesic efficacy of the OFA protocol was significantly superior to that of the OSA protocol presented and was associated with a lower intraoperative rescue analgesia requirement and early postoperative pain scores.

目的比较无阿片(OFA)和有阿片(OSA)麻醉方案对接受腹腔镜卵巢切除术的狗围术期的镇痛效果:前瞻性、随机、盲法临床试验:动物:28 只客户饲养的狗:狗被分配到两组中的一组。OFA 组肌肉注射(IM)右美托咪定 5 μg kg-1 和氯胺酮 1 mg kg-1,然后术中两次恒速输注(CRI)右美托咪定(3 μg kg-1-小时-1)和利多卡因(1 mg kg-1 负荷剂量,2 mg kg-1-小时-1)。OSA 组使用 5 μg kg-1右美托咪定、1 mg kg-1氯胺酮和 0.2 mg kg-1美沙酮进行即时注射,然后在术中使用两次生理盐水 CRI。两组患者均使用 2 毫克/公斤-1 丙泊酚和 0.2 毫克/公斤-1 地西泮静脉注射麻醉,并使用异氟醚维持麻醉。如果心血管变量与刺激前相比增加了 20%,则静脉注射右美托咪定(0.5 μg kg-1)进行补救。手术结束后,静脉注射酮咯酸(0.5 毫克/千克)。术后镇痛采用短表-格拉斯哥综合疼痛量表进行评估,如果疼痛评分≥6/24,则注射美沙酮(0.2 毫克/千克)。统计分析包括混合方差分析、卡方检验和曼-惠特尼U检验:结果:各组间术中监测变量无明显差异。OFA 组的术中镇痛抢救需求量明显较低(p = 0.016),术后 3 小时(p = 0.001)和 6 小时(p < 0.001)的疼痛评分也较低。没有狗在术后使用美沙酮镇痛药:尽管两组犬的术后疼痛评分均可接受,无需进一步干预,但 OFA 方案的镇痛效果明显优于 OSA 方案,且术中镇痛抢救需求和术后早期疼痛评分均较低。
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J. Araos , J. Brandly , E. Gorenberg , A. Adler , B. Driessen , K. Hopster
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Electroencephalographic and cardiovascular changes associated with simultaneous propofol and ketamine constant rate of infusion anesthesia in dogs 在狗身上同时使用异丙酚和氯胺酮恒速输注麻醉时的脑电图和心血管变化
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引用次数: 0
期刊
Veterinary anaesthesia and analgesia
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