Veterinary anaesthesia and analgesia最新文献

英文中文

Peri-anaesthetic management for portal vein venotomy in a dog 犬门静脉切开术的围麻醉处理

IF 1.9 2区农林科学 Q2 VETERINARY SCIENCES

Veterinary anaesthesia and analgesia

Pub Date : 2025-10-27 DOI: 10.1016/j.vaa.2025.08.023

L. Paolella, F. Cinti, B. Hertel, E. Bortolami

引用次数: 0

Preliminary evaluation of the effects of cannabidiol via buccal administration, with or without oral carprofen, in alleviating osteoarthritis-associated pain in dogs 初步评估大麻二酚通过口腔给药，联合或不联合口服卡洛芬，减轻犬骨关节炎相关疼痛的效果

IF 1.9 2区农林科学 Q2 VETERINARY SCIENCES

Veterinary anaesthesia and analgesia

Pub Date : 2025-10-27 DOI: 10.1016/j.vaa.2025.08.006

T. Vake, K. Tomsič, Ž. Žgank, T. Snoj

引用次数: 0

Differences in distribution of ventilation between lateral and sternal recumbency in common Hippopotami measured by Electrical Impedance Tomography 电阻抗断层扫描测量普通河马侧卧位和胸骨卧位通气分布的差异

IF 1.9 2区农林科学 Q2 VETERINARY SCIENCES

Veterinary anaesthesia and analgesia

Pub Date : 2025-10-27 DOI: 10.1016/j.vaa.2025.08.015

K.N. Kuek , R. Lindeboom , F. Pohlin , J.P. Raath , L. Laubscher , A. Semjonov , M. Mosing

引用次数: 0

Evaluation of the effects of pregabalin for the management of hospitalized feral cats 普瑞巴林治疗住院野猫的效果评价

IF 1.9 2区农林科学 Q2 VETERINARY SCIENCES

Veterinary anaesthesia and analgesia

Pub Date : 2025-10-27 DOI: 10.1016/j.vaa.2025.08.016

M. Laguardia, C. Piemontese, M. Polvere, C. Bruno, M. Albrizio, F. Gernone, F. Staffieri

引用次数: 0

Survey of teaching methods for small animal anaesthesia to undergraduate veterinary students in Australia and New Zealand 澳大利亚和新西兰兽医本科学生小动物麻醉教学方法的调查

IF 1.9 2区农林科学 Q2 VETERINARY SCIENCES

Veterinary anaesthesia and analgesia

Pub Date : 2025-10-27 DOI: 10.1016/j.vaa.2025.08.020

G.C. Musk, K. Smith, A.L. Raisis, J. Davis, M. Mosing

引用次数: 0

Pharmacokinetics of ropivacaine after intraperitoneal instillation in anaesthetized dogs: a randomized clinical trial 麻醉犬腹腔注射罗哌卡因的药代动力学：一项随机临床试验。

IF 1.9 2区农林科学 Q2 VETERINARY SCIENCES

Veterinary anaesthesia and analgesia

Pub Date : 2025-10-20 DOI: 10.1016/j.vaa.2025.10.002

Natali Verdier , Karin Hummel , Valentin Al-Jalali , Svenja Claaßen , Pablo A. Donati , Diego A. Portela , Ebrahim Razzazi-Fazeli , Martina Mosing

Objective

To evaluate the pharmacokinetics of two doses of intraperitoneal ropivacaine in anaesthetized dogs.

Study design

Randomized clinical trial.

Animals

A total of 20 dogs undergoing ovariectomy/ovariohysterectomy.

Methods

Dogs were anaesthetized and randomized to be given 1 (group R1) or 3 (group R3) mg kg^-1 of ropivacaine intraperitoneally, diluted with 0.9% NaCl to a total volume of 0.8 mL kg^-1. Before abdominal wall closure, solution aliquots were instilled over the ovarian pedicles and, if applicable, the uterine stump. Venous blood was sampled 2 minutes before and 5, 10, 15, 30, 45, 60, 120 and 240 minutes after instillation. Cardiovascular signs of toxicity were noted. Plasma concentrations of free and total ropivacaine were measured using ultrahigh-performance liquid chromatography–mass spectrometry. Plasma protein binding (PPB) was determined by rapid equilibrium dialysis. Pharmacokinetic parameters were derived by a noncompartmental analysis, and the maximum total and free ropivacaine plasma concentrations (Cmax) were compared between groups using an independent samples t-test. Data are presented as mean or median (95% confidence intervals). Significance was set at p < 0.05.

Results

One dog in R3 was excluded. Total ropivacaine Cmax values were 0.27 (0.21–0.33) and 0.67 (0.43–0.92) mg L^-1 at 15 (8.64–30.35) and 5 (1.77–8.23) minutes (Tmax) for R1 and R3, respectively, and different between groups (p = 0.005). Free ropivacaine Cmax values were 0.02 (0.02–0.03) and 0.06 (0.03–0.09) mg L^-1 at 10 (4.67–15.32) and 5 (0–19.13) minutes (Tmax) for R1 and R3, respectively, and Cmax was different between groups (p = 0.015). Median ropivacaine PPB for all dogs was 92.5% (89.7–95.2%). No signs of cardiovascular toxicity were noted.

Conclusions and clinical relevance

Although R3 had a greater total and free ropivacaine Cmax than R1, Cmax remained below toxic levels in all dogs.

目的：评价两种剂量罗哌卡因在麻醉犬体内的药动学。研究设计：随机临床试验。动物：共20只接受卵巢/卵巢子宫切除术的狗。方法：犬麻醉后，随机给予1 （R1组）或3 （R3组）mg kg-1罗哌卡因腹腔注射，0.9% NaCl稀释至总容积0.8 mL kg-1。在关闭腹壁之前，将溶液等分液灌注到卵巢蒂上，如果适用的话，也灌注到子宫残端上。分别于给药前2分钟和给药后5、10、15、30、45、60、120、240分钟取静脉血。注意到心血管中毒症状。采用超高效液相色谱-质谱法测定游离罗哌卡因和总罗哌卡因的血浆浓度。快速平衡透析法测定血浆蛋白结合（PPB）。通过非室室分析获得药代动力学参数，并采用独立样本t检验比较两组间罗哌卡因最大总浓度和游离浓度（Cmax）。数据以平均值或中位数（95%置信区间）表示。p < 0.05为显著性。结果：1只狗在R3中被排除。R1和R3在15（8.64-30.35）和5 (1.77-8.23)min （Tmax）时，总罗哌卡因Cmax值分别为0.27（0.21-0.33）和0.67 (0.43-0.92)mg L-1，组间差异有统计学意义（p = 0.005）。R1和R3在10（4.67 ~ 15.32）和5 (0 ~ 19.13)min （Tmax）时游离罗哌卡因Cmax值分别为0.02（0.02 ~ 0.03）和0.06 (0.03 ~ 0.09)mg L-1，组间Cmax值差异有统计学意义（p = 0.015）。所有犬的罗哌卡因PPB中位数为92.5%（89.7-95.2%）。没有发现心血管毒性的迹象。结论和临床意义：虽然R3的总游离罗哌卡因Cmax高于R1，但所有犬的Cmax均低于毒性水平。

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引用次数: 0

Looking forward and reflecting back: Learning from the London 60th anniversary meeting 前瞻与反思：从伦敦60周年纪念会议中学习。

IF 1.9 2区农林科学 Q2 VETERINARY SCIENCES

Veterinary anaesthesia and analgesia

Pub Date : 2025-10-16 DOI: 10.1016/j.vaa.2025.09.007

Louise Clark

引用次数: 0

The association between injectable non-steroidal anti-inflammatory drugs and acute kidney injury in dogs and cats 可注射非甾体抗炎药与狗和猫急性肾损伤之间的关系。

IF 1.9 2区农林科学 Q2 VETERINARY SCIENCES

Veterinary anaesthesia and analgesia

Pub Date : 2025-09-19 DOI: 10.1016/j.vaa.2025.09.006

Matthew K. Wun , Michael H. Court , Nicolas F. Villarino , Richard Malik

Over the past 20 years, injectable non-steroidal anti-inflammatory drugs (NSAIDs) have become widely adopted to provide routine analgesia to dogs and cats, including perioperatively. This is despite growing evidence associating their use with acute kidney injury, particularly in relation to the use of meloxicam in cats. In this Perspective, we summarise the evidence obtained from pharmacovigilance agencies and the veterinary literature, examine why proponents of injectable NSAIDs appear to discard this evidence, and discuss whether injectable NSAIDs are an obligatory component of multimodal analgesia. Finally, we offer alternative analgesic drug regimens and call for further research that could be undertaken before injectable NSAIDs can be used safely in dogs and cats.

在过去的20年里，可注射的非甾体抗炎药（NSAIDs）已被广泛用于犬和猫的常规镇痛，包括围手术期。尽管越来越多的证据表明它们的使用与急性肾损伤有关，特别是与猫使用美洛昔康有关。在这一观点中，我们总结了从药物警戒机构和兽医文献中获得的证据，研究了为什么注射类非甾体抗炎药的支持者似乎放弃了这一证据，并讨论了注射类非甾体抗炎药是否是多模式镇痛的强制性组成部分。最后，我们提供了替代的镇痛药物方案，并呼吁在可注射的非甾体抗炎药可以安全地用于狗和猫之前进行进一步的研究。

引用次数: 0

Comparison of two immobilisation protocols (medetomidine-midazolam and alfaxalone-midazolam) for restraint of urban red foxes (Vulpes vulpes) : a pilot study 两种固定方案（美托咪定-咪达唑仑和阿法沙酮-咪达唑仑）对城市红狐（Vulpes Vulpes）约束的比较：一项试点研究。

IF 1.9 2区农林科学 Q2 VETERINARY SCIENCES

Veterinary anaesthesia and analgesia

Pub Date : 2025-09-12 DOI: 10.1016/j.vaa.2025.09.004

Patricia Romero Marco , Holly M. English , Barry Nolan , Simone Ciuti , Rachel C. Bennett , Vilhelmiina Huuskonen

Objective

To compare two immobilisation protocols for the restraint of urban red foxes: medetomidine-midazolam (MM) and alfaxalone-midazolam (AM).

Study design

Prospective, randomised clinical trial.

Animals

Fourteen urban red foxes (Vulpes vulpes) captured in the Dublin metropolitan area.

Methods

Foxes were randomly assigned to receive either MM [medetomidine 0.07 mg kg^-1, midazolam 0.8 mg kg^-1 intramuscularly (IM)] or AM (alfaxalone 3 mg kg^-1, midazolam 0.8 mg kg^-1 IM). Sedation and recovery were scored. Recovery times and physiological variables [heart rate, respiratory rate (f_R), oscillometric arterial blood pressure, arterial haemoglobin oxygen saturation (SpO₂) and rectal temperature] were measured. Hair and blood samples were collected for cortisol analysis. Sedation was reversed with atipamezole (0.35 mg kg^-1 IM) and/or flumazenil (0.01 mg kg^-1 IM). Recovery ended when foxes walked with coordinated movements. Data were analysed using linear and mixed-effects models.

Results

Seven foxes were given MM and seven AM. Median sedation scores were higher in MM (14.5 versus 12.5; p = 0.048), with shorter reversal times (25 versus 54 minutes; p = 0.009). Heart rate was lower (80 versus 216 beats per minute^-1; p < 0.001) and mean arterial blood pressure higher (147 versus 110 mmHg; p < 0.001) in MM. SpO₂ was higher in AM (95 versus 91%; p = 0.015). Rectal temperature was higher in MM (38.6 versus 36.5 °C; p < 0.001), with a faster decrease in AM (p = 0.006). f_R did not differ between groups (p = 0.492) but increased with higher ambient temperature (p = 0.04) and decreased with higher hair cortisol levels (p = 0.02).

Conclusions and clinical relevance

Both protocols provided sufficient sedation for intended procedures. MM resulted in higher sedation scores and faster recovery after antagonist administration, while AM provided higher SpO₂ and heart rates and lower rectal temperature values.

目的：比较美托咪定-咪达唑仑（MM）和阿法沙酮-咪达唑仑（AM）两种固定方法对城市红狐的抑制作用。研究设计：前瞻性、随机临床试验。动物：在都柏林市区捕获的14只城市红狐。方法：将狐狸随机分为MM组（美托咪定0.07 mg kg-1，咪达唑仑0.8 mg kg-1）和AM组（阿法索龙3 mg kg-1，咪达唑仑0.8 mg kg-1）。对镇静和恢复情况进行评分。测量恢复时间和生理指标[心率、呼吸频率（fR）、动脉血压、动脉血红蛋白氧饱和度（SpO2）和直肠温度]。收集头发和血液样本进行皮质醇分析。阿替帕唑（0.35 mg kg-1 IM）和/或氟马西尼（0.01 mg kg-1 IM）逆转镇静作用。当狐狸以协调的动作行走时，恢复结束。使用线性和混合效应模型分析数据。结果：给7只狐狸MM和7只AM。MM患者镇静评分中位数较高（14.5比12.5,p = 0.048），逆转时间较短（25比54分钟，p = 0.009）。MM组心率较低（80比216次/分钟，p < 0.001），平均动脉血压较高（147比110 mmHg， p < 0.001）， AM组SpO2较高（95比91%，p = 0.015）。MM组直肠温度较高（38.6°C vs 36.5°C; p < 0.001）， AM组下降较快（p = 0.006）。fR组间无差异（p = 0.492），但随环境温度升高而升高（p = 0.04），随毛发皮质醇水平升高而降低（p = 0.02）。结论和临床意义：两种方案都为预期的手术提供了足够的镇静。MM导致更高的镇静评分和拮抗剂使用后更快的恢复，而AM提供更高的SpO2和心率以及更低的直肠温值。

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引用次数: 0

Intra-rater reliability, expertise and justifications for the American society of anesthesiologists physical status classification in dogs 美国麻醉师协会犬类生理状态分类的内部可靠性、专业知识和合理性。

IF 1.9 2区农林科学 Q2 VETERINARY SCIENCES

Veterinary anaesthesia and analgesia

Pub Date : 2025-09-12 DOI: 10.1016/j.vaa.2025.09.003

Henrique E. de Almeida Lupiano , Erik H. Hofmeister , Pen-Ting Liao

Objective

The purposes of this study were to document intra-rater reliability in assigning American Society of Anesthesiologists Physical Status Classification System (ASA) status, to compare Cochran–Weiss–Shanteau (CWS) scores between anesthetists with varying levels of external validation, and to document the explanations given for assigning certain ASA statuses.

Study design

Prospective case series.

Subjects

A group of 29 anesthetists.

Methods

Anesthetists were presented with 25 hypothetical cases in two stages and asked to provide an ASA status as well as an explanation. Intra-rater reliability was calculated using the single-measure averaged intraclass correlation coefficient (ICC). The CWS index was calculated and quantifies expertise by assessing discrimination and consistency, where higher scores indicate superior judgment. Explanations for assignment of ASA status were analyzed by inductive coding by two investigators.

Results

The intra-rater ICC for all raters who completed Stage 1 and 2 was 0.80 (95% confidence interval 0.76–0.83, n = 17), 0.80 (0.74–0.86, n = 6) for Diplomates, 0.76 (0.68–0.82, n = 5) for residents and 0.86 (0.81–0.90, n = 6) for veterinary technicians. CWS ranged from 2.0 to 6.1, with the same median score of 3.1 for Diplomates, residents and technicians. In cases with the lowest agreement, the themes identified included disagreement on the degree of physiological compensation (e.g. tachycardia) and the effects of mild dehydration, an asymptomatic heart murmur, patients with brachycephalic airway syndrome and hypoproteinemia.

Conclusions and clinical relevance

Intra-rater reliability was high and similar regardless of level of external validation (i.e. technician vs. resident versus Diplomate). Using the CWS for ASA status assignment did not differentiate technicians, residents and Diplomates, although some individuals had relatively higher CWS, suggesting greater expertise in ASA status assignment. Disagreements exist in classifying conditions like brachycephalic airway syndrome and asymptomatic heart murmurs.

目的：本研究的目的是记录评定美国麻醉师协会身体状态分类系统（ASA）状态时的内部信度，比较具有不同外部验证水平的麻醉师之间的Cochran-Weiss-Shanteau （CWS）评分，并记录评定某些ASA状态的解释。研究设计：前瞻性病例系列。研究对象：麻醉医师29人。方法：麻醉医师分两个阶段对25例患者进行假设，并要求其提供ASA状态和解释。使用单测量平均类内相关系数（ICC）计算组内信度。计算CWS指数，并通过评估歧视和一致性来量化专业知识，其中得分越高表明判断力越好。两位研究者通过归纳编码分析了ASA状态分配的解释。结果：完成第一阶段和第二阶段的所有评分者的评分者内部ICC为0.80(95%置信区间0.76-0.83,n = 17)，文凭为0.80 (0.74-0.86,n = 6)，居民为0.76 (0.68-0.82,n = 5)，兽医技师为0.86 （0.81-0.90,n = 6）。CWS介乎2.0至6.1，而外交官、居民及技术人员的得分中位数均为3.1。在一致性最低的病例中，确定的主题包括生理代偿程度（如心动过速）和轻度脱水、无症状心脏杂音、短头气道综合征和低蛋白血症患者的影响。结论和临床相关性：无论外部验证水平如何（即技术人员、住院医生和专科医生），内部信度都很高且相似。使用CWS进行ASA身份分配并没有区分技师、居民和外交家，尽管有些人的CWS相对较高，表明他们在ASA身份分配方面更专业。对短头气道综合征和无症状心杂音的分类存在分歧。

{"title":"Intra-rater reliability, expertise and justifications for the American society of anesthesiologists physical status classification in dogs","authors":"Henrique E. de Almeida Lupiano , Erik H. Hofmeister , Pen-Ting Liao","doi":"10.1016/j.vaa.2025.09.003","DOIUrl":"10.1016/j.vaa.2025.09.003","url":null,"abstract":"<div><h3>Objective</h3><div>The purposes of this study were to document intra-rater reliability in assigning American Society of Anesthesiologists Physical Status Classification System (ASA) status, to compare Cochran–Weiss–Shanteau (CWS) scores between anesthetists with varying levels of external validation, and to document the explanations given for assigning certain ASA statuses.</div></div><div><h3>Study design</h3><div>Prospective case series.</div></div><div><h3>Subjects</h3><div>A group of 29 anesthetists.</div></div><div><h3>Methods</h3><div>Anesthetists were presented with 25 hypothetical cases in two stages and asked to provide an ASA status as well as an explanation. Intra-rater reliability was calculated using the single-measure averaged intraclass correlation coefficient (ICC). The CWS index was calculated and quantifies expertise by assessing discrimination and consistency, where higher scores indicate superior judgment. Explanations for assignment of ASA status were analyzed by inductive coding by two investigators.</div></div><div><h3>Results</h3><div>The intra-rater ICC for all raters who completed Stage 1 and 2 was 0.80 (95% confidence interval 0.76–0.83, <em>n</em> = 17), 0.80 (0.74–0.86, <em>n</em> = 6) for Diplomates, 0.76 (0.68–0.82, <em>n</em> = 5) for residents and 0.86 (0.81–0.90, <em>n</em> = 6) for veterinary technicians. CWS ranged from 2.0 to 6.1, with the same median score of 3.1 for Diplomates, residents and technicians. In cases with the lowest agreement, the themes identified included disagreement on the degree of physiological compensation (e.g. tachycardia) and the effects of mild dehydration, an asymptomatic heart murmur, patients with brachycephalic airway syndrome and hypoproteinemia.</div></div><div><h3>Conclusions and clinical relevance</h3><div>Intra-rater reliability was high and similar regardless of level of external validation (i.e. technician vs. resident <em>versus</em> Diplomate). Using the CWS for ASA status assignment did not differentiate technicians, residents and Diplomates, although some individuals had relatively higher CWS, suggesting greater expertise in ASA status assignment. Disagreements exist in classifying conditions like brachycephalic airway syndrome and asymptomatic heart murmurs.</div></div>","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":"52 6","pages":"Pages 747-754"},"PeriodicalIF":1.9,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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