Veterinary anaesthesia and analgesia最新文献

英文中文

Improvement of oxygenation and shunt fraction following lung lobectomy during selective lung ventilation with the Uniblocker in a dog during propofol-dexmedetomidine anaesthesia. 异丙酚-右美托咪定麻醉犬单阻断剂选择性肺通气期间肺肺叶切除术后氧合和分流分数的改善。

IF 1.9 2区农林科学 Q2 VETERINARY SCIENCES

Veterinary anaesthesia and analgesia

Pub Date : 2025-11-27 DOI: 10.1016/j.vaa.2025.11.005

Valeria Martín Bellido, Federico Corletto

引用次数: 0

Pharmacological profiles of intravenously and subcutaneously administered fentanyl in the rabbit (Oryctolagus cuniculus) 兔静脉注射和皮下注射芬太尼的药理学特征（Oryctolagus cuculus）

IF 1.9 2区农林科学 Q2 VETERINARY SCIENCES

Veterinary anaesthesia and analgesia

Pub Date : 2025-11-25 DOI: 10.1016/j.vaa.2025.11.003

Vanessa Bettembourg, Lena Olsén, Anneli Rydén, Josefin Brock von Rein, Erica Gumpert Herlofson, Malin Erkas, Patricia Hedenqvist

Objective

To measure the bioavailability, maximal plasma concentration (C_max) and half-life (t_½) of fentanyl in rabbits after intravenous (IV) and subcutaneous (SC) administration. Secondary aims were to investigate behavioural effects and faeces production.

Study design

Randomized, experimental, crossover study.

Animals

A group of six male New Zealand White rabbits, Crl:KBL(NZW), aged 5–6 months and weighing 2.9–3.7 kg.

Methods

Fentanyl 15 μg kg^–1 was administered IV and SC to rabbits with a 14 day washout period. Plasma was sampled at 2 (IV), 5, 10, 15, 30, 60, 90, 120 (IV + SC), 300 (SC) and 390 (SC) minutes and analysed by liquid chromatography–mass spectrometry. Sedation was scored from 0–3, 3 being most sedated, 10 and 45 minutes after administration by an assessor blinded to treatment. Oxygen was supplemented if the haemoglobin oxygen saturation (SpO₂) was <90%. After the experiment, faeces and urine were weighed. Data are presented as mean ± standard deviation or median (range).

Results

Bioavailability for fentanyl after SC administration was 47% ± 16% and 50% (27%–68%). The t_½ for fentanyl after IV and SC administration was 65 ± 11 and 275 ± 16 minutes, respectively. The C_max of fentanyl after SC injection was 0.55 ± 0.17 ng mL^–1 and the time to maximal concentration (T_max) was 15 (15–68) minutes. Median sedation score at 10 minutes was higher (p = 0.014) after IV than after SC administration (3 and 1, respectively). After IV administration, but not SC administration, 5/6 rabbits became recumbent and 2/6 rabbits required oxygen. There was no statistically significant difference in faecal/urinary output between groups.

Conclusions and clinical relevance

Fentanyl administered SC as the sole drug to conscious rabbits resulted in variable plasma concentrations substantially lower than after IV administration. Supplemental oxygen should be available whenever fentanyl is administered.

目的测定芬太尼在兔体内静脉（IV）和皮下（SC）给药后的生物利用度、最大血药浓度（Cmax）和半衰期（t½）。次要目的是调查行为影响和粪便产生。研究设计随机、实验、交叉研究。动物组：6只雄性新西兰大白兔，rl:KBL(NZW)， 5-6个月大，体重2.9-3.7公斤。方法采用芬太尼15 μg kg-1静脉滴注和SC给药，洗脱期14 d。分别在2 （IV）、5、10、15、30、60、90、120 （IV + SC）、300 （SC）和390 (SC) min采集血浆，采用液相色谱-质谱联用分析。镇静评分从0-3分，3分为最镇静，10分钟和45分钟给药后由盲法评估。当血红蛋白氧饱和度（SpO2）为90%时补充氧气。实验结束后，对粪便和尿液进行称重。数据以平均值±标准差或中位数（范围）表示。结果SC给药后芬太尼的生物利用度分别为47%±16%和50%（27% ~ 68%）。静脉注射芬太尼和皮下注射芬太尼的时间分别为65±11分钟和275±16分钟。SC注射后芬太尼的Cmax为0.55±0.17 ng mL-1，达到最大浓度时间（Tmax）为15 (15 ~ 68)min。静脉注射后10分钟镇静评分中位数高于注射SC后（分别为3分和1分）（p = 0.014）。静脉给药后，5/6的家兔变成平卧，2/6的家兔需要氧气。两组间的排便量和排尿量无统计学差异。结论及临床意义清醒家兔单独给药芬太尼后，其血浆浓度明显低于静脉给药。只要给芬太尼，就应该有补充氧气。

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引用次数: 0

Comparison of PetMAP digital and Mindray wrist oscillometric blood pressure measurements with invasive blood pressure in anaesthetized bonobos (Pan paniscus). 麻醉倭黑猩猩（Pan paniscus）的PetMAP数字和迈瑞手腕振荡血压测量与有创血压的比较。

IF 1.9 2区农林科学 Q2 VETERINARY SCIENCES

Veterinary anaesthesia and analgesia

Pub Date : 2025-11-01 DOI: 10.1016/j.vaa.2025.10.009

Philippa Bucknell, Florence Hillen, Phillipa Dobbs, Samantha Ashfield, Kate White

Objective: To evaluate the agreement of the PetMAP noninvasive blood pressure (NIBP) device with digital cuff and the Mindray NIBP device with wrist cuff with invasive blood pressure (IBP) in bonobos.

Study design: Prospective clinical study (non-blinded or -randomized).

Animals: A group of 12 bonobos aged 5-44 years undergoing anaesthesia for enclosure movement and health checks.

Methods: Systolic (SAP), diastolic (DAP) and mean (MAP) arterial pressure measurements were recorded simultaneously at 5-minute intervals using the NIBP devices and IBP via anterior tibial artery cannulation. Modified Bland-Altman and adapted error grid analyses assessed agreement between IBP and NIBP and the clinical implications of any biases respectively. A 95% limit of agreement (LOA) estimated the possible magnitude of sampling error. Pearson r correlations between IBP and NIBP measurements were calculated. A p < 0.05 was considered significant.

Results: IBP ranges were SAP 50-137 mmHg, MAP 32-85 mmHg and DAP 20-69 mmHg. Biases with the PetMAP were -6.8 mmHg for SAP (LOA -41.3 to 27.7 mmHg), -7.2 mmHg for MAP (LOA -30.7 to 16.3 mmHg) and -3.1 mmHg for DAP (LOA -25.5 to 19.3 mmHg) from 84 PetMAP-IBP paired measurements. Correlation coefficients were 0.6 for SAP and DAP and 0.7 for MAP. Whilst 70% of MAP values were clinically acceptable, 13% demonstrated unrecognised hypotension. The Mindray demonstrated biases of -25.3 mmHg for SAP (LOA -69.5 to 18.9 mmHg), -17.5 mmHg for MAP (LOA -51.4 to 16.5 mmHg) and -14.4 mmHg for DAP (LOA -42.2 to 13.5 mmHg) from 95 Mindray-IBP paired measurements. Correlation coefficients were 0.7 for all. Only 45% of MAP values were clinically acceptable and 26% demonstrated unrecognised hypotension.

Conclusions and clinical relevance: Whilst the PetMAP agreed more closely with IBP, neither device met all the American College of Veterinary Internal Medicine validation criteria, and neither should be used to identify hypotension.

目的：评价PetMAP带数字袖带的无创血压仪（NIBP）与迈瑞带腕带的无创血压仪（NIBP）测量倭黑猩猩有创血压（IBP）的一致性。研究设计：前瞻性临床研究（非盲法或随机法）。动物：一组12只5-44岁的倭黑猩猩正在接受麻醉，以进行圈地运动和健康检查。方法：采用NIBP装置和胫前动脉插管IBP，每隔5分钟同时记录动脉收缩压（SAP）、舒张压（DAP）和平均动脉压（MAP）。修正Bland-Altman和修正误差网格分析分别评估了IBP和NIBP之间的一致性和任何偏差的临床意义。95%的一致性限制（LOA）估计了可能的抽样误差幅度。计算IBP和NIBP测量值之间的Pearson相关性。A < 0.05被认为是显著的。结果：IBP范围SAP 50 ~ 137 mmHg， MAP 32 ~ 85 mmHg, DAP 20 ~ 69 mmHg。PetMAP- ibp 84次配对测量的SAP偏差为-6.8 mmHg (LOA为-41.3至27.7 mmHg)， MAP偏差为-7.2 mmHg (LOA为-30.7至16.3 mmHg)， DAP偏差为-3.1 mmHg （LOA为-25.5至19.3 mmHg）。SAP和DAP的相关系数为0.6，MAP的相关系数为0.7。虽然70%的MAP值在临床上是可接受的，但13%表现为无法识别的低血压。在95次Mindray- ibp配对测量中，SAP的偏差为-25.3 mmHg (LOA -69.5至18.9 mmHg)， MAP的偏差为-17.5 mmHg (LOA -51.4至16.5 mmHg)， DAP的偏差为-14.4 mmHg （LOA -42.2至13.5 mmHg）。相关系数均为0.7。只有45%的MAP值是临床可接受的，26%表现为无法识别的低血压。结论和临床相关性：虽然PetMAP与IBP更接近，但这两种设备都不符合美国兽医内科学院的所有验证标准，也不应用于识别低血压。

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引用次数: 0

Peri-anaesthetic complications in dogs undergoing lateral thoracotomy or median sternotomy: A retrospective study. 犬行外侧开胸或正中胸骨切开术的围麻醉并发症：一项回顾性研究。

IF 1.9 2区农林科学 Q2 VETERINARY SCIENCES

Veterinary anaesthesia and analgesia

Pub Date : 2025-10-30 DOI: 10.1016/j.vaa.2025.10.007

Clara Maria de Celis Perez, Luiz Santos, Rob Ward

Objective: To investigate the incidence of peri-anaesthetic complications in dogs undergoing general anaesthesia for thoracic surgery (lateral thoracotomy or median sternotomy) and to identify differences in the rate of peri-anaesthetic complications depending on the surgical approach and American Society of Anesthesiologists (ASA) physical status classification system.

Study design: Retrospective study.

Animals: Dogs that underwent either thoracotomy or sternotomy at The Small Animal Hospital, University of Edinburgh, between January 2019 and August 2022.

Methods: Data recorded included signalment, surgical approach, indication for surgery, general anaesthesia time, surgery time, time to extubation, anaesthetic management and the use of locoregional anaesthetic techniques, neuromuscular blockers, anticholinergics and/or vasopressor and inotropic agents. The occurrence of peri-anaesthetic complications (yes/no) was analysed by surgical approach and ASA classification using chi-square analysis and logistic regression. Statistical significance was set at p < 0.05.

Results: A total of 127 anaesthetic records were reviewed, of which 90 met the inclusion criteria; ASA scores were missing from nine leaving 81. Median sternotomy was associated with a significantly longer surgical (p = 0.03) and anaesthetic time (p < 0.01) as well as the time to extubation (p = 0.023). Hypothermia (n = 72) and hypotension (n = 54) were the most prevalent complications observed despite surgical approach or ASA status. Hypoxaemia was more likely to occur in dogs with ASA status IV (n = 10/29) than in dogs with ASA status II and III (n = 7/52) in chi-square analysis (p = 0.026) and binomial logistic regression (p = 0.046).

Conclusions and clinical relevance: Hypothermia and hypotension were common peri-anaesthetic complications. Higher ASA status was associated with a higher likelihood of hypoxaemia, and no significant association was found between complications and surgical approach. Active warming from the premedication stage and ensuring prompt access to fluid therapy, vasopressors, inotropes and anticholinergics are recommended.

目的：探讨全麻犬胸外科手术（外侧开胸术或正中开胸术）的围麻醉并发症发生率，并探讨不同手术入路和美国麻醉医师协会（ASA）身体状态分类系统对围麻醉并发症发生率的影响。研究设计：回顾性研究。动物：2019年1月至2022年8月期间在爱丁堡大学小动物医院接受开胸或胸骨切开术的狗。方法：记录的数据包括信号、手术入路、手术指征、全麻时间、手术时间、拔管时间、麻醉管理和局部麻醉技术、神经肌肉阻滞剂、抗胆碱能药和/或血管加压药和肌力药物的使用。采用卡方分析和logistic回归分析手术入路和ASA分类，分析麻醉周围并发症（是/否）发生情况。p < 0.05为差异有统计学意义。结果：共审查127份麻醉记录，其中90份符合纳入标准；81人中有9人没有ASA分数。胸骨正中切开术显著延长手术时间（p = 0.03）、麻醉时间（p < 0.01）和拔管时间（p = 0.023）。低温（72例）和低血压（54例）是手术入路或ASA状态下最常见的并发症。卡方分析（p = 0.026）和二项logistic回归分析（p = 0.046）显示，ASA IV状态犬（n = 10/29）较ASA II和III状态犬（n = 7/52）更易发生低氧血症。结论及临床意义：低温和低血压是常见的麻醉周围并发症。ASA水平越高，低氧血症的可能性越高，并发症与手术入路之间没有明显关联。建议从用药前阶段开始积极加热，并确保及时获得液体疗法、血管加压药、肌力药物和抗胆碱能药物。

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引用次数: 0

Pharmacokinetics of intravenously administered maropitant in pigs (a pilot study) 静脉给药马洛匹坦在猪体内的药代动力学（初步研究）

IF 1.9 2区农林科学 Q2 VETERINARY SCIENCES

Veterinary anaesthesia and analgesia

Pub Date : 2025-10-27 DOI: 10.1016/j.vaa.2025.08.030

M. Pavlica , U.L. Tratar , M. Čemažar , U. Stupan , M. Đokić , J. Sredenšek , J. Plut , M. Kržan , T. Kosjek , A. Seliškar

引用次数: 0

Respiratory monitoring using electrical impedance tomography (EIT) with and without an endotracheal tube during recovery from anesthesia in mesocephalic and brachycephalic dogs 应用电阻抗断层扫描（EIT）观察中脑病和短脑病犬麻醉恢复期间有无气管内插管的呼吸监测

IF 1.9 2区农林科学 Q2 VETERINARY SCIENCES

Veterinary anaesthesia and analgesia

Pub Date : 2025-10-27 DOI: 10.1016/j.vaa.2025.08.003

L. Biber , A. Wong , M. Mosing

引用次数: 0

Assessment of sedation and recovery following subcutaneous injection of midazolam and two doses of flumazenil in bearded dragons (Pogona vitticeps) 皮下注射咪达唑仑和两剂氟马西尼对大胡子龙镇静和恢复的评价

IF 1.9 2区农林科学 Q2 VETERINARY SCIENCES

Veterinary anaesthesia and analgesia

Pub Date : 2025-10-27 DOI: 10.1016/j.vaa.2025.08.017

R.H. Pinho , M. Teng , M. Reed , K. Chapman , D.S.J. Pang

引用次数: 0

Pharmacokinetics of tramadol and o-desmethyltramadol metabolite in boa (Boa constrictor constrictor) 曲马多及o-去甲基曲马多代谢物在蟒蛇体内的药动学

IF 1.9 2区农林科学 Q2 VETERINARY SCIENCES

Veterinary anaesthesia and analgesia

Pub Date : 2025-10-27 DOI: 10.1016/j.vaa.2025.08.033

M. Lopes , N. Maldonado , L. Fagundes , N. Eleuterio , J. Goncalves , M. Carvalho , F. Leme , N. Fagundes , S. Beier

引用次数: 0

Feasibility of electrical impedance monitoring of dogs in an intensive care unit 在重症监护病房对狗进行电阻抗监测的可行性

IF 1.9 2区农林科学 Q2 VETERINARY SCIENCES

Veterinary anaesthesia and analgesia

Pub Date : 2025-10-27 DOI: 10.1016/j.vaa.2025.08.026

K. Unger, M. Mosing

引用次数: 0

Retroperitoneal haematoma after ultrasound-guided ventro-dorsal quadratus lumborum interfascial plane block in two dogs 超声引导腰腹背方肌筋膜面阻滞后腹膜后血肿2例

IF 1.9 2区农林科学 Q2 VETERINARY SCIENCES

Veterinary anaesthesia and analgesia

Pub Date : 2025-10-27 DOI: 10.1016/j.vaa.2025.08.022

K. Fontana, T. Mozzillo, E. Bortolami

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Veterinary anaesthesia and analgesia

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