Wellcome Open Research最新文献

We present a genome assembly from a male specimen of Hybos culiciformis (hybotid fly; Arthropoda; Insecta; Diptera; Hybotidae). The genome sequence has a total length of 342.56 megabases. Most of the assembly (90.73%) is scaffolded into 5 chromosomal pseudomolecules, including the X and Y sex chromosomes. The mitochondrial genome has also been assembled, with a length of 17.59 kilobases. Gene annotation of this assembly on Ensembl identified 20 872 protein-coding genes. This assembly was generated as part of the Darwin Tree of Life project, which produces reference genomes for eukaryotic species found in Britain and Ireland.

We present a genome assembly from an individual female Stictoleptura scutellata (longhorn beetle; Arthropoda; Insecta; Coleoptera; Cerambycidae). The assembly contains two haplotypes with total lengths of 1 471.09 megabases and 1 480.10 megabases. Most of haplotype 1 (99.33%) is scaffolded into 10 chromosomal pseudomolecules, including the X sex chromosome, while haplotype 2 was assembled to scaffold level. The mitochondrial genome has also been assembled, with a length of 17.97 kilobases. This assembly was generated as part of the Darwin Tree of Life project, which produces reference genomes for eukaryotic species found in Britain and Ireland.

We present a genome assembly from a male specimen of Watsonalla cultraria (Barred Hook-tip; Arthropoda; Insecta; Lepidoptera; Drepanidae). The genome sequence has a total length of 319.38 megabases. Most of the assembly (99.94%) is scaffolded into 31 chromosomal pseudomolecules, including the Z sex chromosome. Gene annotation of this assembly on Ensembl identified 16 011 protein-coding genes. The mitochondrial genome has also been assembled, with a length of 15.21 kilobases.

We present a genome assembly from an individual male Polypogon plumigeralis (Plumed Fan-foot; Arthropoda; Insecta; Lepidoptera; Erebidae). The assembly contains two haplotypes with total lengths of 639.54 megabases and 639.39 megabases. Most of the haplotype 1 sequence (99.54%) is scaffolded into 31 chromosomal pseudomolecules, including the Z sex chromosome. Haplotype 2 was assembled to scaffold level. The mitochondrial genome has also been assembled, with a length of 16.98 kilobases. This assembly was generated as part of the Darwin Tree of Life project, which produces reference genomes for eukaryotic species found in Britain and Ireland.

We present a genome assembly from an individual Acer campestre (the field maple; Tracheophyta; Magnoliopsida; Sapindales; Sapindaceae). The genome sequence is 565.1 megabases in span. Most of the assembly is scaffolded into 14 chromosomal pseudomolecules, in comprising 13 large chromosomes and one smaller B chromosome.. The mitochondrial and plastid genome assemblies have lengths of 769.91 kilobases and 156.29 kilobases in length, respectively. This assembly was generated as part of the Darwin Tree of Life project, which produces reference genomes for eukaryotic species found in Britain and Ireland.

We present a genome assembly from an individual male Orthonevra brevicornis (hoverfly; Arthropoda; Insecta; Diptera; Syrphidae). The assembly contains two haplotypes with total lengths of 788.61 megabases and 718.58 megabases. Most of haplotype 1 (91.69%) is scaffolded into 6 chromosomal pseudomolecules, including the X chromosome. Haplotype 2 was assembled to scaffold level. The mitochondrial genome has also been assembled, with a length of 17.36 kilobases. This assembly was generated as part of the Darwin Tree of Life project, which produces reference genomes for eukaryotic species found in Britain and Ireland.

Introduction: Fetal monitoring is a crucial component of antenatal care, facilitating early detection of fetal compromise and improving pregnancy outcomes. Traditional monitoring methods such as cardiotocography (CTG) and ultrasound are effective but primarily limited to clinical settings, requiring specialized expertise and resources. The rise of wearable medical devices and artificial intelligence (AI) applications presents an opportunity to enhance fetal monitoring by enabling continuous, real-time data collection outside clinical environments. These technologies have the potential to improve fetal health and obstetric outcomes, particularly in resource-limited settings. This systematic review aims to evaluate the use of wearable devices for antenatal fetal monitoring and their impact on fetal and obstetric outcomes.

Methods and analysis: This systematic review will adhere to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and the Synthesis Without Meta-analysis (SWiM) framework. A comprehensive search of PubMed, Embase, Cochrane Library, and Web of Science will be conducted to identify primary research studies investigating wearable devices designed for fetal monitoring during pregnancy. Studies will be included if they assess the effectiveness, accuracy, and clinical impact of wearable fetal monitoring devices. Primary outcomes will include markers of fetal well-being as well as neonatal and obstetric outcomes. Secondary outcomes will focus on patient experience and acceptability. Data extraction and quality assessment will be conducted independently by two reviewers using the National Institutes of Health (NIH) Quality Assessment Tool and the Newcastle-Ottawa Scale. A narrative synthesis will be performed to summarise the findings.

Ethics and dissemination: Ethical approval is not required since the study involves analysing published literature. The findings will be shared through peer-reviewed publications and conference presentations. This review will enhance the evidence base regarding the clinical utility of wearable fetal monitoring technologies and inform future research and device development. PROSPERO Registration: CRD4202348755 (current version 4.1).

Introduction: Sickle cell disease affects tribal communities unequally. Self-management empowers the patient to take corrective actions, improve decision-making, and deepen understanding of the disease. Considering the unique challenges of the tribal community, implementing self-management complementary to the prescribed clinical management for sickle cell disease care can lead to greater autonomy, improved health outcomes, and, ultimately, quality of life. Hence, this study aims to develop a feasible and acceptable self-management package for tribal persons living with Sickle cell disease and caregivers residing in the Mysuru and Chamarajanagar districts of Karnataka.

Method: The study will be conducted in two phases. In the first phase, a self-management package will be developed with insights from health providers working with Persons living with sickle cell disease, non-government organisations, Subject experts and persons with sickle cell disease and caregiver. This package will be implemented in the second phase for persons living with sickle cell disease. Participants will undergo capacity-building training and receive regular follow-up for 12 months through monthly telephonic calls and a few home visits. Assessment will be done with Acceptability Intervention Measurement (AIM) and Feasibility Intervention Measurement (FIM) at regular intervals. Suggestions and feedback will be added to make the package more comprehensive. Thus, the expected outcome is an acceptable and feasible self-management package.

Conclusion: This proposed study is an important step towards addressing a critical gap in sickle cell disease management in tribal populations in India. The anticipated outcome of this research is to enhance self-management practices in individuals with sickle cell disease.

We present a genome assembly from an individual female Priocnemis perturbator (spider-hunting wasp; Arthropoda; Insecta; Hymenoptera; Pompilidae). The genome sequence has a total length of 391.62 megabases. Most of the assembly (67.88%) is scaffolded into 15 chromosomal pseudomolecules. The mitochondrial genome has also been assembled, with a length of 28.93 kilobases. Gene annotation of this assembly on Ensembl identified 24 581 protein-coding genes. This assembly was generated as part of the Darwin Tree of Life project, which produces reference genomes for eukaryotic species found in Britain and Ireland.

We present a genome assembly from an individual Bathysaurus mollis (highfin lizardfish; Chordata; Actinopteri; Aulopiformes; Bathysauridae). The genome sequence has a total length of 1 065.77 megabases. Most of the assembly (95.16%) is scaffolded into 24 chromosomal pseudomolecules. The mitochondrial genome has also been assembled, with a length of 16.68 kilobases. This assembly was generated as part of the Darwin Tree of Life project, which produces reference genomes for eukaryotic species found in Britain and Ireland.