Wellcome Open Research最新文献

We present a genome assembly from an individual female Nesoenas mayeri (the Pink Pigeon; Chordata; Aves; Columbiformes; Columbidae). The genome sequence is 1,183.3 megabases in span. Most of the assembly is scaffolded into 40 chromosomal pseudomolecules, including the Z and W sex chromosomes. The mitochondrial genome has also been assembled and is 16.97 kilobases in length. Gene annotation of this assembly on Ensembl identified 16,730 protein coding genes. The primary assembly achieves the Earth Biogenome Project reference standard of 6.C.Q62.

Background: Governance is central to health systems, and achieving Universal Health Coverage (UHC) relies on strong, sustainable systems. However, despite UHC's broad health goals, issues like oral health receive inadequate attention, signalling inequity in health systems. In India, oral diseases are rising, yet oral health remains a low political priority, reflecting weak governance and limited state commitment to health equity. This study analysed governance factors within Karnataka's public oral healthcare system through the lens of Siddiqi's health governance assessment framework.

Methods: In this exploratory qualitative study, in-depth interviews with twenty stakeholders, including administrators and program implementers, explored enablers and constraints at policy and operational levels. Data analysis was guided by the governance framework developed by Siddiqi and colleagues.

Results: The findings indicate that challenges persist while Karnataka's oral health governance benefits from a separate directorate ensuring administrative functionality. These include a lack of strategic vision for oral health, inadequate policy formulation, limited social participation, insufficient budget, workforce shortages, outdated guidelines, and inequitable oral health programs. Power dynamics, particularly with district health officers, further hinder effective governance. The study reveals a siloed approach to oral health with minimal integration into broader health programs. From planning to implementation, weak governance links reflect low political will.

Conclusion: Although recent attention has been given to oral health in Karnataka, substantial reforms are necessary. These include appointing oral health personnel at primary health centres, increasing budgets, revising the Indian Public Health Standards to prioritise oral health in primary care, empowering the oral health directorate, and establishing accountability and surveillance systems. Strengthening governance in these areas is essential to advance oral health equity and contribute to UHC goals in Karnataka.

We present a genome assembly from an individual female Adscita geryon (Cistus Forester; Arthropoda; Insecta; Lepidoptera; Zygaenidae). The assembly contains two haplotypes with total lengths of 764.63 megabases and 670.15 megabases. Most of haplotype 1 (99.63%) is scaffolded into 32 chromosomal pseudomolecules, including the W and Z sex chromosomes. Haplotype 2 was assembled to scaffold level. The mitochondrial genome has also been assembled, with a length of 15.32 kilobases. This assembly was generated as part of the Darwin Tree of Life project, which produces reference genomes for eukaryotic species found in Britain and Ireland.

We present the genome assemblies of three females of the Danio rerio strains, AB, Nadia and Cooch Behar (zebrafish; Chordata; Actinopteri; Cypriniformes; Cyprinidae). These assemblies were released in 2020 as part of the Danioninae Sequencing Project. The genome sequence of the strain AB is 1,405.10 megabases, the Nadia strain 1,465.10, and the Cooch Behar strain 1,421.80 megabases in length. Most of the assembly is scaffolded into 25 chromosomal pseudomolecules in each case. For each strain, the mitochondrial genome was also assembled and is 16.6 kilobases in length.

We present a genome assembly from an individual male Sussaba pulchella (ichneumonid wasp; Arthropoda; Insecta; Hymenoptera; Ichneumonidae). The genome sequence has a total length of 299.91 megabases. Most of the assembly (81.88%) is scaffolded into 15 chromosomal pseudomolecules. The mitochondrial genome has also been assembled, with a length of 34.69 kilobases. This assembly was generated as part of the Darwin Tree of Life project, which produces reference genomes for eukaryotic species found in Britain and Ireland.

We present a genome assembly from an individual Bimastos rubidus (Cockspur worm; Annelida; Clitellata; Crassiclitellata; Lumbricidae). The genome sequence has a total length of 812.74 megabases. Most of the assembly (95.63%) is scaffolded into 17 chromosomal pseudomolecules. The mitochondrial genome has also been assembled, with a length of 16.57 kilobases. This assembly was generated as part of the Darwin Tree of Life project, which produces reference genomes for eukaryotic species found in Britain and Ireland.

We present a genome assembly from a female specimen of Danio aesculapii (the Panther Danio; Chordata; Actinopteri; Cypriniformes; Cyprinidae). The genome sequence is 1,381.5 megabases in span. Most of the assembly is scaffolded into 25 chromosomal pseudomolecules. Gene annotation of this assembly on Ensembl identified 23,884 protein coding genes.

We present a genome assembly from an individual male Cnephasia stephensiana (Grey Tortrix; Arthropoda; Insecta; Lepidoptera; Tortricidae). The assembly contains two haplotypes with total lengths of 465.14 megabases and 465.69 megabases. Most of haplotype 1 (99.5%) is scaffolded into 30 chromosomal pseudomolecules, including the Z sex chromosome. Haplotype 2 was assembled to scaffold level. The mitochondrial genome has also been assembled, with a length of 16.63 kilobases. This assembly was generated as part of the Darwin Tree of Life project, which produces reference genomes for eukaryotic species found in Britain and Ireland.

In January 2024, the Kenya Ministry of Health issued an outbreak alert following a surge in acute hemorrhagic conjunctivitis (AHC) cases along the Kenyan coast. Our investigations identified coxsackievirus A24 variant (CV-A24v) as the causative agent. In this study, we developed a novel whole genome sequencing assay for CV-A24v, and used it to recover three near complete genomes from the 2024 AHC outbreak in Kenya. This method will support future studies on CV-A24v genomic epidemiology and evolution across Kenya and beyond.

We present a genome assembly from an individual male Netelia melanura (ichneumonid wasp; Arthropoda; Insecta; Hymenoptera; Ichneumonidae). The genome sequence has a total length of 253.87 megabases. Most of the assembly (94.81%) is scaffolded into 7 chromosomal pseudomolecules. The mitochondrial genome has also been assembled, with a length of 28.04 kilobases. This assembly was generated as part of the Darwin Tree of Life project, which produces reference genomes for eukaryotic species found in Britain and Ireland.