Wellcome Open Research最新文献

We present a genome assembly from a male specimen of Watsonalla cultraria (Barred Hook-tip; Arthropoda; Insecta; Lepidoptera; Drepanidae). The genome sequence has a total length of 319.38 megabases. Most of the assembly (99.94%) is scaffolded into 31 chromosomal pseudomolecules, including the Z sex chromosome. Gene annotation of this assembly on Ensembl identified 16 011 protein-coding genes. The mitochondrial genome has also been assembled, with a length of 15.21 kilobases.

We present a genome assembly from an individual male Orthonevra brevicornis (hoverfly; Arthropoda; Insecta; Diptera; Syrphidae). The assembly contains two haplotypes with total lengths of 788.61 megabases and 718.58 megabases. Most of haplotype 1 (91.69%) is scaffolded into 6 chromosomal pseudomolecules, including the X chromosome. Haplotype 2 was assembled to scaffold level. The mitochondrial genome has also been assembled, with a length of 17.36 kilobases. This assembly was generated as part of the Darwin Tree of Life project, which produces reference genomes for eukaryotic species found in Britain and Ireland.

Introduction: Fetal monitoring is a crucial component of antenatal care, facilitating early detection of fetal compromise and improving pregnancy outcomes. Traditional monitoring methods such as cardiotocography (CTG) and ultrasound are effective but primarily limited to clinical settings, requiring specialized expertise and resources. The rise of wearable medical devices and artificial intelligence (AI) applications presents an opportunity to enhance fetal monitoring by enabling continuous, real-time data collection outside clinical environments. These technologies have the potential to improve fetal health and obstetric outcomes, particularly in resource-limited settings. This systematic review aims to evaluate the use of wearable devices for antenatal fetal monitoring and their impact on fetal and obstetric outcomes.

Methods and analysis: This systematic review will adhere to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and the Synthesis Without Meta-analysis (SWiM) framework. A comprehensive search of PubMed, Embase, Cochrane Library, and Web of Science will be conducted to identify primary research studies investigating wearable devices designed for fetal monitoring during pregnancy. Studies will be included if they assess the effectiveness, accuracy, and clinical impact of wearable fetal monitoring devices. Primary outcomes will include markers of fetal well-being as well as neonatal and obstetric outcomes. Secondary outcomes will focus on patient experience and acceptability. Data extraction and quality assessment will be conducted independently by two reviewers using the National Institutes of Health (NIH) Quality Assessment Tool and the Newcastle-Ottawa Scale. A narrative synthesis will be performed to summarise the findings.

Ethics and dissemination: Ethical approval is not required since the study involves analysing published literature. The findings will be shared through peer-reviewed publications and conference presentations. This review will enhance the evidence base regarding the clinical utility of wearable fetal monitoring technologies and inform future research and device development. PROSPERO Registration: CRD4202348755 (current version 4.1).

Introduction: Sickle cell disease affects tribal communities unequally. Self-management empowers the patient to take corrective actions, improve decision-making, and deepen understanding of the disease. Considering the unique challenges of the tribal community, implementing self-management complementary to the prescribed clinical management for sickle cell disease care can lead to greater autonomy, improved health outcomes, and, ultimately, quality of life. Hence, this study aims to develop a feasible and acceptable self-management package for tribal persons living with Sickle cell disease and caregivers residing in the Mysuru and Chamarajanagar districts of Karnataka.

Method: The study will be conducted in two phases. In the first phase, a self-management package will be developed with insights from health providers working with Persons living with sickle cell disease, non-government organisations, Subject experts and persons with sickle cell disease and caregiver. This package will be implemented in the second phase for persons living with sickle cell disease. Participants will undergo capacity-building training and receive regular follow-up for 12 months through monthly telephonic calls and a few home visits. Assessment will be done with Acceptability Intervention Measurement (AIM) and Feasibility Intervention Measurement (FIM) at regular intervals. Suggestions and feedback will be added to make the package more comprehensive. Thus, the expected outcome is an acceptable and feasible self-management package.

Conclusion: This proposed study is an important step towards addressing a critical gap in sickle cell disease management in tribal populations in India. The anticipated outcome of this research is to enhance self-management practices in individuals with sickle cell disease.

We present a genome assembly from an individual Bathysaurus mollis (highfin lizardfish; Chordata; Actinopteri; Aulopiformes; Bathysauridae). The genome sequence has a total length of 1 065.77 megabases. Most of the assembly (95.16%) is scaffolded into 24 chromosomal pseudomolecules. The mitochondrial genome has also been assembled, with a length of 16.68 kilobases. This assembly was generated as part of the Darwin Tree of Life project, which produces reference genomes for eukaryotic species found in Britain and Ireland.

We present a genome assembly from an individual female Priocnemis perturbator (spider-hunting wasp; Arthropoda; Insecta; Hymenoptera; Pompilidae). The genome sequence has a total length of 391.62 megabases. Most of the assembly (67.88%) is scaffolded into 15 chromosomal pseudomolecules. The mitochondrial genome has also been assembled, with a length of 28.93 kilobases. Gene annotation of this assembly on Ensembl identified 24 581 protein-coding genes. This assembly was generated as part of the Darwin Tree of Life project, which produces reference genomes for eukaryotic species found in Britain and Ireland.

Background: Understanding how interventions work requires clear hypotheses, rigorous testing, and accurate reporting of links between behaviour change techniques (BCTs)-the smallest replicable active components of interventions-and mechanisms of action (MoAs), the processes through which behaviour changes. The Theory and Techniques Tool (TaTT) provides a grid of likely BCT-MoA links to guide intervention design, based on literature synthesis and expert consensus. Recently, the Behaviour Change Intervention Ontology development team introduced detailed, computer-readable lower-level ontologies for BCTs and MoAs, but limited guidance exists on integrating the BCT-MoA links proposed by the TaTT with these ontologies. This study aimed to map BCTs and MoAs from the TaTT to corresponding classes (i.e., categorisations or groupings) in the Behaviour Change Technique Ontology (BCTO) and Mechanism of Action (MoA) Ontology.

Methods: Three researchers mapped the classes from the BCTO onto 74 BCTs within the TaTT, using their definitions. Similarly, two researchers mapped classes from the MoA Ontology onto the 26 MoAs within the TaTT. Discrepancies were resolved through discussion with senior researchers. Subsequent updates to the BCT and MoA Ontologies necessitated a researcher updating the mappings, with the revisions being verified by the research team.

Results: From the BCTO, 85 BCTs were mapped to the 74 BCTs present in the TaTT, while 56 MoAs from the MoA Ontology were mapped to the 26 MoAs present in the TaTT. Subclasses of these 85 BCTs and 56 MoAs provide additional specificity and can be found by further engaging with these ontologies.

Discussion: Mapping the TaTT to the Behaviour Change Intervention Ontology enhances clarity and precision in selecting and reporting BCT-MoA links, enabling integration of data across frameworks. Future work should maintain these mappings as ontologies evolve and users provide more feedback and evidence on BCTs, MoAs and their links, ensuring they remain relevant and user-friendly.

We present a genome assembly from an individual male Thera firmata (Pine Carpet; Arthropoda; Insecta; Lepidoptera; Geometridae). The assembly contains two haplotypes with total lengths of 301.47 megabases and 300.34 megabases. Most of haplotype 1 (98.51%) is scaffolded into 19 chromosomal pseudomolecules, including the Z sex chromosome. Haplotype 2 was assembled to scaffold level. Gene annotation of this assembly on Ensembl identified 11 832 protein-coding genes. The mitochondrial genome has also been assembled, with a length of 16.59 kilobases. This assembly was generated as part of the Darwin Tree of Life project, which produces reference genomes for eukaryotic species found in Britain and Ireland.

We present a genome assembly from an individual male Cauchas fibulella (Speedwell Longhorn; Arthropoda; Insecta; Lepidoptera; Adelidae). The assembly contains two haplotypes with total lengths of 578.63 megabases and 573.48 megabases. The whole sequence for haplotype 1 is scaffolded into 25 chromosomal pseudomolecules, including the Z chromosome. Most of haplotype 2 (97.29%) is scaffolded into 25 chromosomal pseudomolecules, also including a Z chromosome. The mitochondrial genome has also been assembled, with a length of 15.77 kilobases. This assembly was generated as part of the Darwin Tree of Life project, which produces reference genomes for eukaryotic species found in Britain and Ireland.

We present a genome assembly from an individual male Xyphosia miliaria (tephritid fruit fly; Arthropoda; Insecta; Diptera; Tephritidae). The assembly contains two haplotypes with total lengths of 806.98 megabases and 799.90 megabases. Most of haplotype 1 (97.34%) is scaffolded into 7 chromosomal pseudomolecules, including the X and Y sex chromosomes. Most of haplotype 2 (83.09%) is scaffolded into 5 chromosomal pseudomolecules. The mitochondrial genome has also been assembled, with a length of 19.41 kilobases. This assembly was generated as part of the Darwin Tree of Life project, which produces reference genomes for eukaryotic species found in Britain and Ireland.