Wellcome Open Research最新文献

We present a genome assembly from an individual female Falcaria lacertinaria (the Scalloped Hook-tip; Arthropoda; Insecta; Lepidoptera; Drepanidae). The genome sequence has a total length of 300.20 megabases. Most of the assembly is scaffolded into 32 chromosomal pseudomolecules, including the W and Z sex chromosomes. The mitochondrial genome has also been assembled and is 16.07 kilobases in length. Gene annotation of this assembly on Ensembl identified 11,709 protein-coding genes.

We present a genome assembly from an individual female shiny-headed wasp-sawfly, Tenthredo amoena (Arthropoda; Insecta; Hymenoptera; Tenthredinidae). The genome sequence has a total length of 199.80 megabases. Most of the assembly (99.95%) is scaffolded into 18 chromosomal pseudomolecules. The mitochondrial genome has also been assembled and is 33.96 kilobases in length.

Background: Depression during pregnancy is associated with pre-term labor, low birthweight, post-partum depression and adverse child outcomes. There are concerns about the safety of anti-depressant medications during pregnancy. Many pregnant women with antenatal depression are neither aware about their depression nor do they have access to non-pharmacological interventions for depression. Evidence suggests that pre-natal yoga can improve antenatal depression. Yoga is native to the Indian culture and women can practice yoga as a 'self-care' intervention with minimal training. There is no study till date on the efficacy of yoga on antenatal depression in pregnant women in a low resource (rural) setting in India. This pilot randomized controlled trial aims to study the feasibility, acceptability, and preliminary efficacy of a YOGA-based lifestyle intervention for Antenatal Depression (YOGA-D) in Maharashtra, India.

Methods: We will undertake a single-blind individual randomized parallel group-controlled pilot trial with 1:1 allocation ratio. Adult women with 12-26 weeks of pregnancy, without any obstetric or medical complications will be randomly allocated to either the active intervention group (Yoga-Sanskar (YS)) or the Enhanced Usual Care (EUC) group. Trained yoga instructors will teach a pre-defined yoga sequence to the participants in the YS arm. In the EUC arm, participants will receive a single session of health education. We will assess trial feasibility using the recruitment, retention, and study completion rates. The primary outcome of depression will be measured using the translated Marathi version of the Patient Health Questionnaire-9. Assessments will be at the baseline, three-months post-randomization, and post-delivery.

Discussion: This study will help us to understand the barriers in implementation of a yoga-based intervention for antenatal depression in a low-resource/rural setting in Maharashtra, India. Based on the learnings of this pilot trial, we plan to undertake an explanatory randomized controlled trial in the next few months.

Registration: CTRI ( CTRI/2024/05/067176; 10/05/2024).

We present a genome assembly from an individual male Mythimna pallens (the Common Wainscot moth; Arthropoda; Insecta; Lepidoptera; Noctuidae). The genome sequence has a total length of 719.10 megabases. Most of the assembly is scaffolded into 31 chromosomal pseudomolecules, including the Z sex chromosome. The mitochondrial genome has also been assembled and is 15.33 kilobases in length. Gene annotation of this assembly on Ensembl identified 18,343 protein-coding genes.

The aim of this data note is to describe the sexual experiences, functioning and behaviour data collected from the parent cohorts of the Avon Longitudinal Study of Parents and Children (ALSPAC) occurring during their childhoods and up to 19 years after the birth of the index child. ALSPAC is an ongoing birth cohort which enrolled 14,541 pregnant women living in Avon, an area of southwest England, with expected dates of delivery between April 1991 and December 1992 inclusive. It continues collecting data on these mothers (age range at delivery <16-41 years), their partners (age range at delivery <16-65), and their offspring, so far resulting in 100,000+ phenotype variables. During the index pregnancy the mothers were asked (and at 8 months post-delivery for partners) about their early sexual experiences to identify sexual abuse, the age at which an event first occurred, along with the type of perpetrator (e.g. stranger, relatives, boy/girlfriend). There are also data on these parents' experiences of sexual assault as adults. Both parents were asked also about sexual abuse within a battery of questions identifying Adverse Childhood Events (ACEs). Further longitudinal data described here includes satisfaction with sexual and non-sexual sides of their relationship; sexual functioning; and at seven years post-delivery, both parents were asked to describe their sexual orientation as well as the sex of their partners. These data provide the ability to compare generational differences between parental sexual experiences and behaviours with those of their offspring, as well as allowing comparisons with other longitudinal surveys where similar (or identical) information has been collected such as the National Survey of Sexual Attitudes and Lifestyles (NATSAL-3). This paper forms a companion to a further data note describing similar data collected on the offspring cohort.

We present a genome assembly from an individual female Leucania comma (the Shoulder-striped Wainscot moth; Arthropoda; Insecta; Lepidoptera; Noctuidae). The genome sequence spans 751.70 megabases. Most of the assembly is scaffolded into 32 chromosomal pseudomolecules, including the Z and W sex chromosomes. The mitochondrial genome has also been assembled and is 15.37 kilobases in length. Gene annotation of this assembly on Ensembl identified 12,477 protein-coding genes.

We present a genome assembly from a juvenile male Cinclus cinclus (the white-throated dipper; Chordata; Aves; Passeriformes; Cinclidae). The genome sequence has a total length of 1,170.80 megabases. Most of the assembly (93.88%) is scaffolded into 39 chromosomal pseudomolecules, including the Z sex chromosome. The mitochondrial genome has also been assembled and is 18.67 kilobases in length.

We present a genome assembly from an individual female solidierfly, Stratiomys singularior (Arthropoda; Insecta; Diptera; Stratiomyidae). The genome sequence has a total length of 715.20 megabases. Most of the assembly is scaffolded into 6 chromosomal pseudomolecules, including the X sex chromosome. The mitochondrial genome has also been assembled and is 15.67 kilobases in length. Gene annotation of this assembly on Ensembl identified 11,614 protein-coding genes.

We present a genome assembly from an individual male Tenthredo scrophulariae (Figwort Sawfly; Arthropoda; Insecta; Hymenoptera; Tenthredinidae). The genome sequence has a total length of 233.10 megabases. Most of the assembly (99.96%) is scaffolded into 10 chromosomal pseudomolecules. The mitochondrial genome has also been assembled and is 26.26 kilobases in length.

We present a genome assembly from an individual male ichneumonid wasp, Pimpla contemplator (Arthropoda; Insecta; Hymenoptera; Ichneumonidae). The genome sequence has a total length of 270.30 megabases. Most of the assembly (92.24%) is scaffolded into 18 chromosomal pseudomolecules. The mitochondrial genome has also been assembled and is 27.79 kilobases in length.