Wellcome Open Research最新文献

The aim of this data note is to describe the sexual experiences, functioning and behaviour data collected from the parent cohorts of the Avon Longitudinal Study of Parents and Children (ALSPAC) occurring during their childhoods and up to 19 years after the birth of the index child. ALSPAC is an ongoing birth cohort which enrolled 14,541 pregnant women living in Avon, an area of southwest England, with expected dates of delivery between April 1991 and December 1992 inclusive. It continues collecting data on these mothers (age range at delivery <16-41 years), their partners (age range at delivery <16-65), and their offspring, so far resulting in 100,000+ phenotype variables. During the index pregnancy the mothers were asked (and at 8 months post-delivery for partners) about their early sexual experiences to identify sexual abuse, the age at which an event first occurred, along with the type of perpetrator (e.g. stranger, relatives, boy/girlfriend). There are also data on these parents' experiences of sexual assault as adults. Both parents were asked also about sexual abuse within a battery of questions identifying Adverse Childhood Events (ACEs). Further longitudinal data described here includes satisfaction with sexual and non-sexual sides of their relationship; sexual functioning; and at seven years post-delivery, both parents were asked to describe their sexual orientation as well as the sex of their partners. These data provide the ability to compare generational differences between parental sexual experiences and behaviours with those of their offspring, as well as allowing comparisons with other longitudinal surveys where similar (or identical) information has been collected such as the National Survey of Sexual Attitudes and Lifestyles (NATSAL-3). This paper forms a companion to a further data note describing similar data collected on the offspring cohort.

We present a genome assembly from an individual female Leucania comma (the Shoulder-striped Wainscot moth; Arthropoda; Insecta; Lepidoptera; Noctuidae). The genome sequence spans 751.70 megabases. Most of the assembly is scaffolded into 32 chromosomal pseudomolecules, including the Z and W sex chromosomes. The mitochondrial genome has also been assembled and is 15.37 kilobases in length. Gene annotation of this assembly on Ensembl identified 12,477 protein-coding genes.

We present a genome assembly from a juvenile male Cinclus cinclus (the white-throated dipper; Chordata; Aves; Passeriformes; Cinclidae). The genome sequence has a total length of 1,170.80 megabases. Most of the assembly (93.88%) is scaffolded into 39 chromosomal pseudomolecules, including the Z sex chromosome. The mitochondrial genome has also been assembled and is 18.67 kilobases in length.

We present a genome assembly from an individual female solidierfly, Stratiomys singularior (Arthropoda; Insecta; Diptera; Stratiomyidae). The genome sequence has a total length of 715.20 megabases. Most of the assembly is scaffolded into 6 chromosomal pseudomolecules, including the X sex chromosome. The mitochondrial genome has also been assembled and is 15.67 kilobases in length. Gene annotation of this assembly on Ensembl identified 11,614 protein-coding genes.

We present a genome assembly from an individual male ichneumonid wasp, Pimpla contemplator (Arthropoda; Insecta; Hymenoptera; Ichneumonidae). The genome sequence has a total length of 270.30 megabases. Most of the assembly (92.24%) is scaffolded into 18 chromosomal pseudomolecules. The mitochondrial genome has also been assembled and is 27.79 kilobases in length.

Previous research on child/teenage sexual experiences has largely focussed on negative outcomes such as teen pregnancy or acquiring sexually transmitted infections and are mainly cross-sectional. Longitudinal research is required to assess normal sexual development and the attainment of psychologically healthy attitudes towards sexuality. The Avon Longitudinal Study of Parents and Children (ALSPAC) has administered questions on relationships and sexual experiences from the age of 11 years to the index children. This data note describes these data.

We present a genome assembly from an individual male Tenthredo scrophulariae (Figwort Sawfly; Arthropoda; Insecta; Hymenoptera; Tenthredinidae). The genome sequence has a total length of 233.10 megabases. Most of the assembly (99.96%) is scaffolded into 10 chromosomal pseudomolecules. The mitochondrial genome has also been assembled and is 26.26 kilobases in length.

We present a genome assembly from a female specimen of Gastrophysa polygoni (knotweed leaf beetle; Arthropoda; Insecta; Coleoptera; Chrysomelidae). The genome sequence has a total length of 369.80 megabases. Most of the assembly (99.89%) is scaffolded into 12 chromosomal pseudomolecules, including the X sex chromosome. The mitochondrial genome has also been assembled and is 17.11 kilobases in length.

We present a genome assembly from a specimen of Black Medic, Medicago lupulina (Streptophyta; Magnoliopsida; Fabales; Fabaceae). The genome sequence has a total length of 575.40 megabases. Most of the assembly is scaffolded into 8 chromosomal pseudomolecules. The mitochondrial and plastid genome assemblies have lengths of 294.12 kilobases and 123.99 kilobases, respectively. Gene annotation of this assembly on Ensembl identified 27,424 protein-coding genes.

Background: Microbial Keratitis (MK) is a leading cause of corneal blindness due to infection and its consequences, with a higher incidence in resource-limited nations. Hospital-based patient records from different parts of Nepal suggest patients often use traditional eye medicine to treat MK. Traditional healers (TH) within the community are often the first point of care for MK management. Little is known of their practice, perceptions, and knowledge around MK management. We aimed to understand the role of traditional healers in the management of MK in south-eastern Nepal.

Methods: A cross-sectional, mixed method, descriptive study was conducted in the Siraha district of Nepal. A total of 109 traditional healers consented to participate in a survey of knowledge, attitude, and practices. Some participants were also invited to participate in in-depth interviews and focus group discussions. Interviews and focus groups were conducted and recorded in the Maithili language by a native speaking interviewer and transcribed into English. Descriptive analysis was performed for the survey. Data saturation was considered the endpoint for qualitative data collection, and a thematic was analysis applied.

Results: Traditional healers believe that infection of the eye can be caused by trauma, conjunctivitis, or evil spirits. They were unclear about differentiating MK from other eye conditions. They provided various types of treatment. Some were confident that they could treat severe ulcers that had not responded to medical therapy, while others thought treating larger diameter ulcers would be difficult. Although there were mixed responses in referring patients with MK, the majority of TH were willing to refer.

Conclusion: In a weak health system, traditional healers may help address barriers to healthcare access and reduce delays to definitive care, upon integration into the formal health system and referral pathway.