Wellcome Open Research最新文献

Controlled human infection models offer a unique opportunity to understand infectious disease pathogenesis and have accelerated vaccine development and evaluations in malaria and typhoid. One major limitation of most CHIMs is that they are typically conducted in healthy young adults who are generally the population least affected by infectious disease, and who exhibit distinct disease profiles to more at-risk populations such as people living with HIV, young children, and older adults. However, the added value of studying these populations with high relevance is only desirable if it can be done safely, robustly and acceptably. We present a framework to guide the conduct of a controlled human infection model in people living with HIV using a case-example of an experimental human pneumococcal carriage model in a setting of high disease-burden and transmission.

We present a genome assembly from an individual female Araneus angulatus (orb-weaver spider; Arthropoda; Arachnida; Araneae; Araneidae). The assembly contains two haplotypes with total lengths of 2 980.91 megabases and 2 941.08 megabases. Most of haplotype 1 (94.74%) is scaffolded into 28 chromosomal pseudomolecules. Haplotype 2 was assembled to scaffold level. The mitochondrial genome has also been assembled, with a length of 14.53 kilobases. This assembly was generated as part of the Darwin Tree of Life project, which produces reference genomes for eukaryotic species found in Britain and Ireland.

We present a genome assembly from an individual female Anthomyza gracilis (anthomyzid fly; Arthropoda; Insecta; Diptera; Anthomyzidae). The assembly contains two haplotypes with total lengths of 576.40 megabases and 595.67 megabases. Most of haplotype 1 (97.03%) is scaffolded into 6 chromosomal pseudomolecules. Haplotype 2 was assembled to scaffold level. The mitochondrial genome has also been assembled, with a length of 16.87 kilobases. This assembly was generated as part of the Darwin Tree of Life project, which produces reference genomes for eukaryotic species found in Britain and Ireland.

We present a genome assembly from an individual male Cataclysta lemnata (Small China-mark; Arthropoda; Insecta; Lepidoptera; Crambidae). The genome sequence has a total length of 432.44 megabases. Most of the assembly (99.51%) is scaffolded into 28 chromosomal pseudomolecules, including the Z sex chromosome. The mitochondrial genome has also been assembled, with a length of 15.36 kilobases. This assembly was generated as part of the Darwin Tree of Life project, which produces reference genomes for eukaryotic species found in Britain and Ireland.

We present a genome assembly from an individual female Chrysops viduatus (Square-spot Deerfly; Arthropoda; Insecta; Diptera; Tabanidae). The genome sequence has a total length of 312.35 megabases. Most of the assembly (87.6%) is scaffolded into 5 chromosomal pseudomolecules. The mitochondrial genome has also been assembled, with a length of 16.08 kilobases. This assembly was generated as part of the Darwin Tree of Life project, which produces reference genomes for eukaryotic species found in Britain and Ireland.

We present a genome assembly from an individual male Phragmataecia castaneae (Reed Leopard moth; Arthropoda; Insecta; Lepidoptera; Cossidae). The assembly contains two haplotypes with total lengths of 590.72 megabases and 591.65 megabases. Most of haplotype 1 (99.8%) is scaffolded into 30 chromosomal pseudomolecules, including the Z sex chromosome. Haplotype 2 was assembled to scaffold level. The mitochondrial genome has also been assembled, with a length of 15.5 kilobases. This assembly was generated as part of the Darwin Tree of Life project, which produces reference genomes for eukaryotic species found in Britain and Ireland.

We present a genome assembly from an individual female Oxystoma pomonae (seed weevil; Arthropoda; Insecta; Coleoptera; Apionidae). The genome sequence has a total length of 1 174.34 megabases. Most of the assembly (99.97%) is scaffolded into 11 chromosomal pseudomolecules, including the X sex chromosome. The mitochondrial genome has also been assembled, with a length of 18.2 kilobases. Gene annotation of this assembly on Ensembl identified 14 352 protein-coding genes. This assembly was generated as part of the Darwin Tree of Life project, which produces reference genomes for eukaryotic species found in Britain and Ireland.

We present a genome assembly from an individual male Aphidecta obliterata (larch ladybird beetle; Arthropoda; Insecta; Coleoptera; Coccinellidae). The genome sequence has a total length of 349.56 megabases. Most of the assembly (97.85%) is scaffolded into 10 chromosomal pseudomolecules, including the X sex chromosome. The mitochondrial genome has also been assembled, with a length of 17.95 kilobases. Gene annotation of this assembly on Ensembl identified 18 868 protein-coding genes. This assembly was generated as part of the Darwin Tree of Life project, which produces reference genomes for eukaryotic species found in Britain and Ireland.

We present the scaffold-level genome assemblies of four Danio species, released in 2020: Danio albolineatus, Danio choprai, Danio jaintianensis and Danio tinwini (Chordata; Actinopterygii; Cypriniformes; Cyprinidae). Genome sizes range from 1,102.16 Mb for Danio choprai to 1,497.36 Mb for Danio tinwini.

We present a genome assembly from an individual female Hypomecis atomaria (Common Heath; Arthropoda; Insecta; Lepidoptera; Geometridae). The genome sequence has a total length of 690.01 megabases. Most of the assembly (99.95%) is scaffolded into 32 chromosomal pseudomolecules, including the W and Z sex chromosomes. The mitochondrial genome has also been assembled, with a length of 15.6 kilobases. This assembly was generated as part of the Darwin Tree of Life project, which produces reference genomes for eukaryotic species found in Britain and Ireland.