Lipid nanocarriers are a useful tool for intracellular delivery of drugs that are otherwise unable to enter their target cells. Most of these nanocarriers are designed for an endocytotic uptake, although this route of intracellular drug delivery has a number of shortcomings. A promising alternative is fusogenic lipid nanocarriers, since by this uptake mechanism lysosomal degradation problems being associated with endocytosis can be excluded and drug release into the target cell can be synchronized with the fusion process. Various mechanisms being responsible for biological fusion events, including fertilization, exocytosis, viral infection and plasma membrane repair can be copied and transferred to nanocarriers enabling them to fuse with target cells. In particular, curvature, fluidity and surface charge of nanocarriers are key parameters for fusogenic properties. Furthermore, lipid nanocarriers can be decorated with fusogenic (poly)peptides such as viral fusion peptides or SNARE-derived lipopeptides. Within this review we provide an overview about the underlying mechanisms being responsible for cell membrane fusion processes, we demonstrate how this knowledge can be utilized for the design of fusogenic lipid nanocarriers and we summarize most promising applications of fusogenic nanocarriers for treatment of different diseases.
{"title":"Fusogenic lipid nanocarriers: Nature-inspired design for advanced drug delivery systems","authors":"Gennaro Balenzano , Numan Eczacioglu , Nunzio Denora , Andreas Bernkop-Schnürch","doi":"10.1016/j.cis.2025.103667","DOIUrl":"10.1016/j.cis.2025.103667","url":null,"abstract":"<div><div>Lipid nanocarriers are a useful tool for intracellular delivery of drugs that are otherwise unable to enter their target cells. Most of these nanocarriers are designed for an endocytotic uptake, although this route of intracellular drug delivery has a number of shortcomings. A promising alternative is fusogenic lipid nanocarriers, since by this uptake mechanism lysosomal degradation problems being associated with endocytosis can be excluded and drug release into the target cell can be synchronized with the fusion process. Various mechanisms being responsible for biological fusion events, including fertilization, exocytosis, viral infection and plasma membrane repair can be copied and transferred to nanocarriers enabling them to fuse with target cells. In particular, curvature, fluidity and surface charge of nanocarriers are key parameters for fusogenic properties. Furthermore, lipid nanocarriers can be decorated with fusogenic (poly)peptides such as viral fusion peptides or SNARE-derived lipopeptides. Within this review we provide an overview about the underlying mechanisms being responsible for cell membrane fusion processes, we demonstrate how this knowledge can be utilized for the design of fusogenic lipid nanocarriers and we summarize most promising applications of fusogenic nanocarriers for treatment of different diseases.</div></div>","PeriodicalId":239,"journal":{"name":"Advances in Colloid and Interface Science","volume":"346 ","pages":"Article 103667"},"PeriodicalIF":19.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145096270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-11DOI: 10.1016/j.cis.2025.103673
Yi'er Lou , Yuanxin Ouyang , Hangyu Xie , Honghong Tian , Siting Li , Min Wu , Xueping Song
Pickering emulsions (PEs) are dispersions stabilized by solid particles, have excellent stability and the ability to efficiently encapsulate and protect active ingredients sensitive to environment. Solid particles play a critical role in ensuring the stability and functionality of emulsions. Smart PEs with stimuli-responsive can respond to external stimuli such as pH, CO2, temperature, light and magnetism to regulate the stability of the emulsion (emulsification or demulsification) and smartly control the release of the encapsulated active ingredient, making them highly valued across multiple industries, exceptionally in the preparation of advanced packaging materials. But conventional solid particles cannot endow the ability with stimuli-response to PEs. As a result, surface functionalization emerges as an essential approach for introducing stimuli responsiveness for nanoparticles as stabilizers of Smart PEs. This review introduces the stabilization mechanism and influencing factors of PEs, summarizes the stimuli-responsive mechanisms of nanoparticles for smart PEs and focus on functionalization employed to introduce stimuli responsiveness for nanoparticles. There has been a significant advance in surface modification of nanoparticles, employing the approaches of chemical grafting, electrostatic adsorption, self-assembly, co-precipitation and encapsulation. Meanwhile, the applications of smart PEs in active packaging, indicator packaging, self-healing packaging, and degradable packaging are presented. The current challenges and future directions of smart PEs applying to advanced packaging materials are also outlined. These insights will be invaluable for optimizing functions of smart PEs and broadening their application potential across various fields.
{"title":"Smart Pickering emulsions stabilized by functionalized nanoparticles: Innovative applications in advanced food packaging","authors":"Yi'er Lou , Yuanxin Ouyang , Hangyu Xie , Honghong Tian , Siting Li , Min Wu , Xueping Song","doi":"10.1016/j.cis.2025.103673","DOIUrl":"10.1016/j.cis.2025.103673","url":null,"abstract":"<div><div>Pickering emulsions (PEs) are dispersions stabilized by solid particles, have excellent stability and the ability to efficiently encapsulate and protect active ingredients sensitive to environment. Solid particles play a critical role in ensuring the stability and functionality of emulsions. Smart PEs with stimuli-responsive can respond to external stimuli such as pH, CO<sub>2</sub>, temperature, light and magnetism to regulate the stability of the emulsion (emulsification or demulsification) and smartly control the release of the encapsulated active ingredient, making them highly valued across multiple industries, exceptionally in the preparation of advanced packaging materials. But conventional solid particles cannot endow the ability with stimuli-response to PEs. As a result, surface functionalization emerges as an essential approach for introducing stimuli responsiveness for nanoparticles as stabilizers of Smart PEs. This review introduces the stabilization mechanism and influencing factors of PEs, summarizes the stimuli-responsive mechanisms of nanoparticles for smart PEs and focus on functionalization employed to introduce stimuli responsiveness for nanoparticles. There has been a significant advance in surface modification of nanoparticles, employing the approaches of chemical grafting, electrostatic adsorption, self-assembly, co-precipitation and encapsulation. Meanwhile, the applications of smart PEs in active packaging, indicator packaging, self-healing packaging, and degradable packaging are presented. The current challenges and future directions of smart PEs applying to advanced packaging materials are also outlined. These insights will be invaluable for optimizing functions of smart PEs and broadening their application potential across various fields.</div></div>","PeriodicalId":239,"journal":{"name":"Advances in Colloid and Interface Science","volume":"346 ","pages":"Article 103673"},"PeriodicalIF":19.3,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-10DOI: 10.1016/j.cis.2025.103671
Hong Wang , Liang Yang , Deying Leng , Yurun Du , Hao Ning
As a novel class of porous materials, metal-organic frameworks (MOFs) have attracted considerable attention due to their extensive applications in gas storage, separation, catalysis, and other fields. Traditional methods for the synthesis and optimization of MOFs are often hindered by time-consuming processes and high costs. With the rapid advancement of machine learning (ML) technology, innovative solutions have been provided to accelerate the design, screening, and performance prediction of MOFs. This paper systematically reviews the progress of ML applications in MOF research, covering multiple aspects from fundamental theories to practical implementations. It first introduces commonly used ML algorithms, including regression analysis, classification algorithms, clustering analysis, deep learning, and reinforcement learning, and discusses methods for data acquisition and preprocessing, as well as their impact on model performance. It also examines model evaluation metrics and strategies for enhancing model interpretability. Subsequently, the paper focuses on how ML can drive the progress of MOF research through material design, high-throughput screening, structure-property relationship analysis, and performance prediction. Finally, it systematically identifies the current challenges and future development directions, emphasizing the importance of interdisciplinary collaboration. The significant value of this review lies in integrating the latest ML technologies with advancements in MOF research, providing researchers with a comprehensive perspective to understand the role of ML in accelerating the development of new materials. Additionally, this paper is of great significance in promoting communication between academia and industry, guiding experimental scientists to more effectively utilize computational tools for MOF-related research, thereby accelerating the development of new materials, advancing green chemistry and technology, and meeting the growing demands for energy and environmental sustainability.
{"title":"Accelerating the discovery and optimization of metal-organic framework materials via machine learning","authors":"Hong Wang , Liang Yang , Deying Leng , Yurun Du , Hao Ning","doi":"10.1016/j.cis.2025.103671","DOIUrl":"10.1016/j.cis.2025.103671","url":null,"abstract":"<div><div>As a novel class of porous materials, metal-organic frameworks (MOFs) have attracted considerable attention due to their extensive applications in gas storage, separation, catalysis, and other fields. Traditional methods for the synthesis and optimization of MOFs are often hindered by time-consuming processes and high costs. With the rapid advancement of machine learning (ML) technology, innovative solutions have been provided to accelerate the design, screening, and performance prediction of MOFs. This paper systematically reviews the progress of ML applications in MOF research, covering multiple aspects from fundamental theories to practical implementations. It first introduces commonly used ML algorithms, including regression analysis, classification algorithms, clustering analysis, deep learning, and reinforcement learning, and discusses methods for data acquisition and preprocessing, as well as their impact on model performance. It also examines model evaluation metrics and strategies for enhancing model interpretability. Subsequently, the paper focuses on how ML can drive the progress of MOF research through material design, high-throughput screening, structure-property relationship analysis, and performance prediction. Finally, it systematically identifies the current challenges and future development directions, emphasizing the importance of interdisciplinary collaboration. The significant value of this review lies in integrating the latest ML technologies with advancements in MOF research, providing researchers with a comprehensive perspective to understand the role of ML in accelerating the development of new materials. Additionally, this paper is of great significance in promoting communication between academia and industry, guiding experimental scientists to more effectively utilize computational tools for MOF-related research, thereby accelerating the development of new materials, advancing green chemistry and technology, and meeting the growing demands for energy and environmental sustainability.</div></div>","PeriodicalId":239,"journal":{"name":"Advances in Colloid and Interface Science","volume":"346 ","pages":"Article 103671"},"PeriodicalIF":19.3,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145061110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Phosphorus (P) removal from water bodies is gaining attention as eutrophication continues to harm biodiversity and the global economy. At the same time, the depletion of finite rock phosphate reserves, a vital resource for plant fertilization, highlights the urgency of sustainable alternatives. Nanomaterials can offer efficient P removal techniques integrated with efficient means of recovering adsorbed P from the water bodies, which could serve as a sustainable source of P fertilizers, an alternative to rock phosphate. This review critically explores the role of nanomaterials (NMs) in the 3-Rs of P management: removal, recovery, and reuse, with a focus on their removal performance, mechanisms, and potential applications. Our analysis highlights that the deposition of metal oxide nanomaterials on support matrices (e.g., clay, biochar, 2D materials) and their entrapment in polymer matrices significantly enhances removal efficiency. The removal process is surface-controlled, influenced by nanomaterial properties, solution chemistry, and competing ions. The recovery and reuse of P-sorbed nanomaterials are evaluated under various scenarios, emphasizing their future potential and proposing improvements to enhance performance. While nanomaterials are promising to advance a P circular economy, large-scale field experiments are critically needed to validate their practical applicability and support the achievement of the United Nations' Sustainable Development Goals.
{"title":"Engineered nanomaterials for removal, recovery, and reuse of phosphorus: From water to fertilizer pathways","authors":"Tonoy Kumar Das , Jashandeep Kaur , Raj Mukhopadhyay , Achintya Bezbaruah , Debankur Sanyal","doi":"10.1016/j.cis.2025.103672","DOIUrl":"10.1016/j.cis.2025.103672","url":null,"abstract":"<div><div>Phosphorus (P) removal from water bodies is gaining attention as eutrophication continues to harm biodiversity and the global economy. At the same time, the depletion of finite rock phosphate reserves, a vital resource for plant fertilization, highlights the urgency of sustainable alternatives. Nanomaterials can offer efficient P removal techniques integrated with efficient means of recovering adsorbed P from the water bodies, which could serve as a sustainable source of P fertilizers, an alternative to rock phosphate. This review critically explores the role of nanomaterials (NMs) in the 3-Rs of P management: removal, recovery, and reuse, with a focus on their removal performance, mechanisms, and potential applications. Our analysis highlights that the deposition of metal oxide nanomaterials on support matrices (e.g., clay, biochar, 2D materials) and their entrapment in polymer matrices significantly enhances removal efficiency. The removal process is surface-controlled, influenced by nanomaterial properties, solution chemistry, and competing ions. The recovery and reuse of P-sorbed nanomaterials are evaluated under various scenarios, emphasizing their future potential and proposing improvements to enhance performance. While nanomaterials are promising to advance a P circular economy, large-scale field experiments are critically needed to validate their practical applicability and support the achievement of the United Nations' Sustainable Development Goals.</div></div>","PeriodicalId":239,"journal":{"name":"Advances in Colloid and Interface Science","volume":"346 ","pages":"Article 103672"},"PeriodicalIF":19.3,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145046492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Over the past 2 decades, per- and polyfluoroalkyl substances (PFAS) have attracted considerable attention due to their widespread occurrence and adverse effects on both the environment and human health. PFAS possess strong carbon‑fluorine bonds that confer exceptional chemical stability and resistance to natural degradation; their fluorinated chains are highly hydrophobic and oleophobic, while their polar functional groups contribute to amphiphilic behavior and water solubility. Certain PFAS thus pose serious risks to living organisms, especially mammals. Membrane filtration is recognized as a particularly effective technique, achieving removal efficiencies greater than 99 % for long-chain-PFAS (including anionic, cationic, and zwitterionic PFAS molecules). However, many conventional membrane processes rely on petroleum-based polymers and non-biodegradable materials which lead to significant sustainability concerns. The disposal of these materials harms the environment and contributes to secondary pollution. In this review, biopolymers are presented as alternatives and their different sources are categorized and discussed in detail. Further, the latest applications of commercial membranes for PFAS removal are discussed and compared with those of biopolymer-based membranes (BBMs). Finally, recommendations for advancing PFAS removal using BBMs are provided, and current knowledge gaps are highlighted. This manuscript therefore underscores the importance of evolving membrane technology within a circular economy framework.
{"title":"Biopolymer-based membranes and their application in per- and polyfluorinated substances removal: Perspective review","authors":"Roham Ghanbari , Ratish Permala , Stefan Iglauer , Masoumeh Zargar","doi":"10.1016/j.cis.2025.103669","DOIUrl":"10.1016/j.cis.2025.103669","url":null,"abstract":"<div><div>Over the past 2 decades, <em>per</em>- and polyfluoroalkyl substances (PFAS) have attracted considerable attention due to their widespread occurrence and adverse effects on both the environment and human health. PFAS possess strong carbon‑fluorine bonds that confer exceptional chemical stability and resistance to natural degradation; their fluorinated chains are highly hydrophobic and oleophobic, while their polar functional groups contribute to amphiphilic behavior and water solubility. Certain PFAS thus pose serious risks to living organisms, especially mammals. Membrane filtration is recognized as a particularly effective technique, achieving removal efficiencies greater than 99 % for long-chain-PFAS (including anionic, cationic, and zwitterionic PFAS molecules). However, many conventional membrane processes rely on petroleum-based polymers and non-biodegradable materials which lead to significant sustainability concerns. The disposal of these materials harms the environment and contributes to secondary pollution. In this review, biopolymers are presented as alternatives and their different sources are categorized and discussed in detail. Further, the latest applications of commercial membranes for PFAS removal are discussed and compared with those of biopolymer-based membranes (BBMs). Finally, recommendations for advancing PFAS removal using BBMs are provided, and current knowledge gaps are highlighted. This manuscript therefore underscores the importance of evolving membrane technology within a circular economy framework.</div></div>","PeriodicalId":239,"journal":{"name":"Advances in Colloid and Interface Science","volume":"346 ","pages":"Article 103669"},"PeriodicalIF":19.3,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-09DOI: 10.1016/j.cis.2025.103651
Kayode Adesina Adegoke , Cecilia Opeyemi Babarinde , Kehinde Nurudeen Awokoya , Olatunde Sunday Oladeji , Oyeladun Rhoda Adegoke , Tunde Lewis Yusuf , Abayomi Bamisaye , Olugbenga Solomon Bello
The uncontrolled discharges of dye effluents into water bodies due to several anthropogenic activities are alarming, necessitating the development and deployment of an effective and environmentally friendly water/wastewater remediation strategy. MILs, UiOs, and ZIFs are fascinating metal-organic frameworks (MOFs) that consist of distinctive components essential for the development of crystals with remarkable surface areas, porosity, outstanding stability, and other adjustable properties. This study presents a comprehensive assessment of the performance of MILs, UiOs, and ZIFs as sorbents for effective dye adsorption from water/wastewater. The suitability of MOF classes for dye decontamination was examined, along with their porosity, ligands, and the parameters influencing their stability. The discussion included different synthetic methods used by MILs, UiOs, and ZIFs, along with their respective advantages and disadvantages. This was also supplemented with the shaping of MOFs. Unlike previous studies, a comprehensive analysis was conducted to evaluate the performance of three MOFs - MILs, UiOs, and ZIFs for the adsorption of dyes from wastewater treatment. The study examined their effectiveness as sorbents for adsorptive dye uptake and addressed their potential uniqueness in detail, providing a current overview of the field. The exceptional performance obtained offers a chance to uncover practical uses in real-world scenarios and acquire an understanding of the associated mechanisms and synergistic relationships. The study further recognized the practical limitations/shortcomings and pinpointed advantageous solutions with these innovative categories of MOFs. To further the practicability and effectiveness of MILs, UiOs, and ZIFs, we highlighted various enhancement choices and knowledge gaps to direct specific future research exploration in expanding their uses on an industrial scale.
{"title":"Dye remediation potentials of MIL, UiO and ZIF metal-organic frameworks and derivatives in wastewater treatment","authors":"Kayode Adesina Adegoke , Cecilia Opeyemi Babarinde , Kehinde Nurudeen Awokoya , Olatunde Sunday Oladeji , Oyeladun Rhoda Adegoke , Tunde Lewis Yusuf , Abayomi Bamisaye , Olugbenga Solomon Bello","doi":"10.1016/j.cis.2025.103651","DOIUrl":"10.1016/j.cis.2025.103651","url":null,"abstract":"<div><div>The uncontrolled discharges of dye effluents into water bodies due to several anthropogenic activities are alarming, necessitating the development and deployment of an effective and environmentally friendly water/wastewater remediation strategy. MILs, UiOs, and ZIFs are fascinating metal-organic frameworks (MOFs) that consist of distinctive components essential for the development of crystals with remarkable surface areas, porosity, outstanding stability, and other adjustable properties. This study presents a comprehensive assessment of the performance of MILs, UiOs, and ZIFs as sorbents for effective dye adsorption from water/wastewater. The suitability of MOF classes for dye decontamination was examined, along with their porosity, ligands, and the parameters influencing their stability. The discussion included different synthetic methods used by MILs, UiOs, and ZIFs, along with their respective advantages and disadvantages. This was also supplemented with the shaping of MOFs. Unlike previous studies, a comprehensive analysis was conducted to evaluate the performance of three MOFs - MILs, UiOs, and ZIFs for the adsorption of dyes from wastewater treatment. The study examined their effectiveness as sorbents for adsorptive dye uptake and addressed their potential uniqueness in detail, providing a current overview of the field. The exceptional performance obtained offers a chance to uncover practical uses in real-world scenarios and acquire an understanding of the associated mechanisms and synergistic relationships. The study further recognized the practical limitations/shortcomings and pinpointed advantageous solutions with these innovative categories of MOFs. To further the practicability and effectiveness of MILs, UiOs, and ZIFs, we highlighted various enhancement choices and knowledge gaps to direct specific future research exploration in expanding their uses on an industrial scale.</div></div>","PeriodicalId":239,"journal":{"name":"Advances in Colloid and Interface Science","volume":"346 ","pages":"Article 103651"},"PeriodicalIF":19.3,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145118100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-08DOI: 10.1016/j.cis.2025.103660
Yunqi Ma , Ruiyu Zhou , Min Yang , Jun Zhang , Wei Song , Xiao Ma , Mingzheng Liu , Xin Cui , Benkai Li , Yanbin Zhang , Yunze Long , Changhe Li
Electrospun scaffolds show strong potential in soft tissue engineering, particularly in promoting the repair of soft tissue lesions, and have attracted increasing research attention in recent years. The macroscopic structure of electrospun scaffolds plays a key role in optimizing mechanical properties, degradation rate, and biocompatibility. These structures can be tailored through post-processing techniques to meet the diverse requirements of different soft tissues. Despite growing interest, current literature lacks a comprehensive review, and clinical reference data remain limited, providing insufficient guidance for practical applications. This paper reviews the structural characteristics and applications of electrospun scaffolds in soft tissue engineering. It first examines soft tissue types and common treatment strategies, followed by a comparative discussion of electrospinning advantages in this context. Structural categories laminar, tubular, three-dimensional (3D), and bundle types are summarized, together with their underlying design principles and corresponding applications. In addition, scaffold post-processing methods and 3D fabrication techniques are reviewed, emphasizing how key structural features affect tissue repair. Finally, existing challenges are outlined, and potential research directions are proposed to support the clinical translation of electrospinning technology in soft tissue regeneration. The findings aim to offer practical guidance for advancing scaffold design and improving repair efficacy.
{"title":"Soft tissue scaffold fabrication based on electrospinning: Application and prospect","authors":"Yunqi Ma , Ruiyu Zhou , Min Yang , Jun Zhang , Wei Song , Xiao Ma , Mingzheng Liu , Xin Cui , Benkai Li , Yanbin Zhang , Yunze Long , Changhe Li","doi":"10.1016/j.cis.2025.103660","DOIUrl":"10.1016/j.cis.2025.103660","url":null,"abstract":"<div><div>Electrospun scaffolds show strong potential in soft tissue engineering, particularly in promoting the repair of soft tissue lesions, and have attracted increasing research attention in recent years. The macroscopic structure of electrospun scaffolds plays a key role in optimizing mechanical properties, degradation rate, and biocompatibility. These structures can be tailored through post-processing techniques to meet the diverse requirements of different soft tissues. Despite growing interest, current literature lacks a comprehensive review, and clinical reference data remain limited, providing insufficient guidance for practical applications. This paper reviews the structural characteristics and applications of electrospun scaffolds in soft tissue engineering. It first examines soft tissue types and common treatment strategies, followed by a comparative discussion of electrospinning advantages in this context. Structural categories laminar, tubular, three-dimensional (3D), and bundle types are summarized, together with their underlying design principles and corresponding applications. In addition, scaffold post-processing methods and 3D fabrication techniques are reviewed, emphasizing how key structural features affect tissue repair. Finally, existing challenges are outlined, and potential research directions are proposed to support the clinical translation of electrospinning technology in soft tissue regeneration. The findings aim to offer practical guidance for advancing scaffold design and improving repair efficacy.</div></div>","PeriodicalId":239,"journal":{"name":"Advances in Colloid and Interface Science","volume":"346 ","pages":"Article 103660"},"PeriodicalIF":19.3,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-08DOI: 10.1016/j.cis.2025.103665
Fuyuan Zhang , Mahmood Alizadeh Sani , Arezou Khezerlou , Mohammad Rezvani-Ghalhari , Xingyu Lin , Ruobing Liu , Elham Assadpour , Xianghong Wang , Tao Yang , Juntao Wang , Seid Mahdi Jafari
Today, the smart sensing platforms concept has been programmable with multiplexed desired target emitters with the emergence of ultra-sensitive diagnosis on nanochip, lab-on-a-chips, and three-dimensional printed devices supporting decision-making with artificial-intelligence. Since carbon nanomaterials such as carbon nanotubes, carbon dots, carbon nanofibers, graphene, and carbon nitride etc., have unique properties such as high selectivity, specificity, and sensitivity, biocompatibility and sustainability, low or non-toxicity, ideal recognition and binding affinity, user-friendliness, variety, ease of preparation or use, and easy tunability, scalability, and modification compared to other nanomaterials, aptasensors decorated with carbon nanomaterials are being considered to monitor and audit food safety and quality control, environmental, bio/nanotechnology, and medicine to detect various targets like biomarkers, heavy metals, antibiotics, pesticides, allergens, and other contaminants. This review paper comprehensively and specifically investigates the characteristics, synthesis, and immobilization of aptasensors based on carbon nanomaterials. The use and integrity of carbon nanomaterials-functionalized aptasensors on portable and electronic devices (microfluidic chip/smartphone) for the tracking and analysis of different hazardous materials, targets, and biomarkers are also covered in this paper. Finally, it addresses how carbon nanomaterials -functionalized aptasensors may be used to monitor and identify targets in the environment and food chain. Therefore, commercialization and industrialization of carbon nanomaterials -functionalized aptasensors as “Lab-on-chip” systems facilitate the tracking and monitoring of hazardous materials/contaminants and various targets in the food chain and environment for consumers and beneficiaries using portable smart electronic tools. Nevertheless, to overcome possible limitations in the construction and introduction of multifunctional carbon nanomaterials -functionalized aptasensors with the capability to use in complex matrices as rapid, portable, and user-friendly, as well as disposable, online/offline and integrated sensors to detect and monitor hazardous material/targets is necessary, which has been highlighted in this study.
{"title":"Advances in aptasensors engineered with carbon nanomaterials for food safety monitoring","authors":"Fuyuan Zhang , Mahmood Alizadeh Sani , Arezou Khezerlou , Mohammad Rezvani-Ghalhari , Xingyu Lin , Ruobing Liu , Elham Assadpour , Xianghong Wang , Tao Yang , Juntao Wang , Seid Mahdi Jafari","doi":"10.1016/j.cis.2025.103665","DOIUrl":"10.1016/j.cis.2025.103665","url":null,"abstract":"<div><div>Today, the smart sensing platforms concept has been programmable with multiplexed desired target emitters with the emergence of ultra-sensitive diagnosis on nanochip, lab-on-a-chips, and three-dimensional printed devices supporting decision-making with artificial-intelligence. Since carbon nanomaterials such as carbon nanotubes, carbon dots, carbon nanofibers, graphene, and carbon nitride etc., have unique properties such as high selectivity, specificity, and sensitivity, biocompatibility and sustainability, low or non-toxicity, ideal recognition and binding affinity, user-friendliness, variety, ease of preparation or use, and easy tunability, scalability, and modification compared to other nanomaterials, aptasensors decorated with carbon nanomaterials are being considered to monitor and audit food safety and quality control, environmental, bio/nanotechnology, and medicine to detect various targets like biomarkers, heavy metals, antibiotics, pesticides, allergens, and other contaminants. This review paper comprehensively and specifically investigates the characteristics, synthesis, and immobilization of aptasensors based on carbon nanomaterials. The use and integrity of carbon nanomaterials-functionalized aptasensors on portable and electronic devices (microfluidic chip/smartphone) for the tracking and analysis of different hazardous materials, targets, and biomarkers are also covered in this paper. Finally, it addresses how carbon nanomaterials -functionalized aptasensors may be used to monitor and identify targets in the environment and food chain. Therefore, commercialization and industrialization of carbon nanomaterials -functionalized aptasensors as “Lab-on-chip” systems facilitate the tracking and monitoring of hazardous materials/contaminants and various targets in the food chain and environment for consumers and beneficiaries using portable smart electronic tools. Nevertheless, to overcome possible limitations in the construction and introduction of multifunctional carbon nanomaterials -functionalized aptasensors with the capability to use in complex matrices as rapid, portable, and user-friendly, as well as disposable, online/offline and integrated sensors to detect and monitor hazardous material/targets is necessary, which has been highlighted in this study.</div></div>","PeriodicalId":239,"journal":{"name":"Advances in Colloid and Interface Science","volume":"346 ","pages":"Article 103665"},"PeriodicalIF":19.3,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145046491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-08DOI: 10.1016/j.cis.2025.103666
Chengwei Zhang , Rebecca Sikkema , Claire Shi , Dalue Tang , Kaiyuan Shi , Igor Zhitomirsky
This review describes new strategies in the use of multifunctional organic alkalizers (OA) for the fabrication of advanced functional materials. OA facilitate solubilization and delivery of poorly solubilized drugs through the formation of drug-OA complexes and supramolecular gels. OA are applied for the synthesis of materials for biomedical, energy storage, catalytic, photovoltaic, sensor, and electronic applications. The synthesis of nanocrystals with controlled size, crystal phase, shape, and tunable facets in the presence of OA-capping agents is described. The synthesis of materials for energy storage in batteries and supercapacitors using OA or adding OA to electrolytes results in improved power-energy characteristics and cyclic stability. The multifunctional OA allow the fabrication of advanced bioceramics and biocements, novel supramolecular gels, surface modification of materials for advanced catalytic, water purification, and sensor applications. Various challenges in the dispersion of functional nanoparticles are addressed for colloidal manufacturing. The ability of the OA to form supramolecular gels paves the way for the development of novel functional materials. New strategies in the solubilization of polymers and other functional materials open an avenue for the development of advanced electrodeposition methods for the deposition of polymer and composite films. Fundamental mechanisms and future research avenues are described.
{"title":"New horizons in synthesis, functionalization, and deposition of advanced materials using multifunctional organic alkalizers","authors":"Chengwei Zhang , Rebecca Sikkema , Claire Shi , Dalue Tang , Kaiyuan Shi , Igor Zhitomirsky","doi":"10.1016/j.cis.2025.103666","DOIUrl":"10.1016/j.cis.2025.103666","url":null,"abstract":"<div><div>This review describes new strategies in the use of multifunctional organic alkalizers (OA) for the fabrication of advanced functional materials. OA facilitate solubilization and delivery of poorly solubilized drugs through the formation of drug-OA complexes and supramolecular gels. OA are applied for the synthesis of materials for biomedical, energy storage, catalytic, photovoltaic, sensor, and electronic applications. The synthesis of nanocrystals with controlled size, crystal phase, shape, and tunable facets in the presence of OA-capping agents is described. The synthesis of materials for energy storage in batteries and supercapacitors using OA or adding OA to electrolytes results in improved power-energy characteristics and cyclic stability. The multifunctional OA allow the fabrication of advanced bioceramics and biocements, novel supramolecular gels, surface modification of materials for advanced catalytic, water purification, and sensor applications. Various challenges in the dispersion of functional nanoparticles are addressed for colloidal manufacturing. The ability of the OA to form supramolecular gels paves the way for the development of novel functional materials. New strategies in the solubilization of polymers and other functional materials open an avenue for the development of advanced electrodeposition methods for the deposition of polymer and composite films. Fundamental mechanisms and future research avenues are described.</div></div>","PeriodicalId":239,"journal":{"name":"Advances in Colloid and Interface Science","volume":"346 ","pages":"Article 103666"},"PeriodicalIF":19.3,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-09-04DOI: 10.1016/j.cis.2025.103662
Katarzyna Szymczyk, Bronisław Jańczuk
The components and parameters of the surface tension of two surfactants of the Kolliphor type (ELP and RH40) and berberine (BBR), the size of the molecules, the contactable area, the adsorption at the solution-air interface, micellization as well as adsorption and micellization thermodynamic parameters were discussed taking the literature data into account. The effects of both surfactants, surfactant+berberine as well as two surfactants+berberine mixtures on the adsorption at the solution-air interface, micellization and thermodynamic parameters were considered. Possible description and prediction of the surface tension isotherms of the aqueous solutions of studied surfactants and their mixtures with berberine were analysed. Considerations on the surface excess concentration of these systems, the mixed monolayer at the solution-air interface and mixed micelles composition as well as thermodynamic parameters of the mixed monolayer and micelles formation were also presented.
{"title":"Adsorption and volumetric properties of berberine and its mixtures with nonionic surfactants of the Kolliphor type","authors":"Katarzyna Szymczyk, Bronisław Jańczuk","doi":"10.1016/j.cis.2025.103662","DOIUrl":"10.1016/j.cis.2025.103662","url":null,"abstract":"<div><div>The components and parameters of the surface tension of two surfactants of the Kolliphor type (ELP and RH40) and berberine (BBR), the size of the molecules, the contactable area, the adsorption at the solution-air interface, micellization as well as adsorption and micellization thermodynamic parameters were discussed taking the literature data into account. The effects of both surfactants, surfactant+berberine as well as two surfactants+berberine mixtures on the adsorption at the solution-air interface, micellization and thermodynamic parameters were considered. Possible description and prediction of the surface tension isotherms of the aqueous solutions of studied surfactants and their mixtures with berberine were analysed. Considerations on the surface excess concentration of these systems, the mixed monolayer at the solution-air interface and mixed micelles composition as well as thermodynamic parameters of the mixed monolayer and micelles formation were also presented.</div></div>","PeriodicalId":239,"journal":{"name":"Advances in Colloid and Interface Science","volume":"346 ","pages":"Article 103662"},"PeriodicalIF":19.3,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145046489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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