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Peripheral nerve tumors in adults and children: clinical and diagnostic characteristics 成人和儿童周围神经肿瘤:临床和诊断特点
Pub Date : 2023-10-18 DOI: 10.17650/1683-3295-2023-25-3-69-77
D. S. Druzhinin, A. S. Karapetyan, M. L. Novikov, E. S. Druzhinina
Aim. To describe clinical and instrumental characteristics of patients with primary solitary and multiple tumors of the peripheral nerves. Materials and methods. Data from 45 patients were analyzed. In accordance with the examination results, the patients were retrospectively divided into 2 groups: 1) with solitary tumors: schwannomas ( n = 22), neurofibromas ( n = 10), perineuriomas ( n = 5), neurofibrosarcomas ( n = 2); 2) with multiple tumors: schwannomatosis ( n = 3) and neurofibromatosis ( n = 3). Results. The study did not show differences in the severity of motor deficit and the results of neurophysiological exams between solitary and multiple tumors; however, differences between pathomorphological types were observed. The most benign disease course was observed in patients with schwannomas, including multiple schwannomas; severe motor deficit was observed in patients with neurofibrosarcomas and crossover neurofibromas. Pain component was characteristic of neurofibrosarcomas, neurofibromas and melanotic schwannoma; perineuriomas were characterized by painless progression. Conclusion. Compulsory scan along the nerve allows to find tumors in clinically intact areas and other nerves.
的目标。描述原发性孤立性和多发性周围神经肿瘤患者的临床和仪器特征。材料和方法。分析了45例患者的数据。根据检查结果将患者回顾性分为2组:1)孤立性肿瘤:神经鞘瘤(22例)、神经纤维瘤(10例)、神经膜瘤(5例)、神经纤维肉瘤(2例);2)多发肿瘤:神经鞘瘤病(n = 3)和神经纤维瘤病(n = 3)。该研究未显示单发和多发肿瘤在运动缺陷的严重程度和神经生理检查结果上存在差异;然而,病理形态类型之间存在差异。神经鞘瘤患者的病程最为良性,包括多发性神经鞘瘤;在神经纤维肉瘤和交叉神经纤维瘤患者中观察到严重的运动障碍。疼痛成分以神经纤维肉瘤、神经纤维瘤和黑色素神经鞘瘤为特征;会膜瘤以无痛进展为特征。结论。沿着神经的强制扫描允许在临床完整的区域和其他神经中发现肿瘤。
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引用次数: 0
Results of cranioplasty using individual titanium implants 单个钛种植体颅骨成形术的结果
Pub Date : 2023-10-17 DOI: 10.17650/1683-3295-2023-25-3-34-42
S. V. Mishinov, N. A. Koporushko, V. V. Stupak
Background. Despite its long history, cranioplasty remains a topical problem of neurosurgery, due to the increasing number of traumatic brain injury, the consequences of which are the main driver in preserving the population of patients with postcranioectomy skull defects. As a rule, these defects are extensive, and the use of individual implants in these cases is the method of choice. Over the past 5 years, the use of products created by medical additive manufacturing has increased, in this regard, the assessment of long-term results of surgical interventions with their use is an actual issue of modern medicine. Aim. To evaluate the results of surgical treatment of patients with skull defects of various etiologies using individual titanium implants made by three-dimensional printing. Materials and methods. The study analyzed 94 cases of cranioplasty using individual titanium implants made by three-dimensional printing using DMLS (Direct Metal Laser Sintering) technology. The minimum follow-up period was 12 months from the moment of the intervention. Traumatic brain injury and its consequences was the dominant cause of skull bone defects ( n = 56, 59.6 %). The average area of defects in the study group was 99.2 ± 43.4 cm 2 . For men ( n = 53), this parameter corresponded to 106.7 ± 44.7 cm 2 , for women ( n = 41) – 89.5 ± 40.1 cm 2 . Results. The total number of complications in the study group was 12 (12.7 %) cases, of which 5 (5.3 %) cases were recorded during the in hospital stay of patients, 7 (7.4 %) – during outpatient follow-up. One complication was not related to the performed surgical intervention. Removal of the implant was required in 7 (7.4 %) cases. The terms of implant removal varied from 0 to 14 months from the moment of the performed intervention. The survival rate of individual titanium implants for more than 12 months was 92.6 %. Conclusion. The data on the presence of complications after cranioplasty vary from study to study, while the results of reconstructive interventions performed using individual titanium implants are of significant interest, the use of which has increased significantly over the past five years due to the introduction of additive medical production into clinical practice.
背景。尽管有悠久的历史,颅成形术仍然是神经外科的一个热门问题,由于创伤性脑损伤的数量不断增加,其后果是保留颅骨切除术后颅骨缺损患者群体的主要驱动因素。通常,这些缺陷是广泛的,在这些情况下使用单个植入物是选择的方法。在过去的5年里,医用增材制造产品的使用有所增加,在这方面,评估手术干预的长期效果是现代医学的一个实际问题。的目标。目的探讨应用三维打印技术制作的个体化钛种植体治疗各种原因的颅骨缺损的手术效果。材料和方法。本研究分析了94例使用DMLS(直接金属激光烧结)技术三维打印制作的单个钛种植体颅骨成形术。最小随访期为干预后12个月。外伤性脑损伤及其后果是颅骨缺损的主要原因(n = 56, 59.6%)。研究组的平均缺损面积为99.2±43.4 cm 2。对于男性(n = 53),该参数对应于106.7±44.7 cm 2,对于女性(n = 41),该参数对应于89.5±40.1 cm 2。结果。研究组共发生并发症12例(12.7%),其中5例(5.3%)发生在住院期间,7例(7.4%)发生在门诊随访期间。其中一个并发症与手术干预无关。7例(7.4%)需要移除种植体。从进行干预的那一刻起,种植体移除的期限从0到14个月不等。单个钛种植体12个月以上的存活率为92.6%。结论。关于颅骨成形术后并发症存在的数据因研究而异,而使用单个钛植入物进行重建干预的结果非常令人感兴趣,由于在临床实践中引入了添加剂医疗生产,其使用在过去五年中显着增加。
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引用次数: 0
Endovascular treatment of distal cerebral aneurysms 脑远端动脉瘤的血管内治疗
Pub Date : 2023-10-17 DOI: 10.17650/1683-3295-2023-25-3-24-33
I. V. Senko, V. S. Kisilev, A. O. Sosnov, A. M. Perfiliev, P. D. Matveev, P. Yu. Ivanova, D. A. Rzaev
Background. Due to rare occurrence of distal cerebral aneurysms, there are very few publications devoted to endovascular treatment. Due to current progress in the endovascular surgery, the number of successfully cured patients with distal aneurysms has been increasing recently. Aim. To determine technical capabilities and evaluate results of endovascular treatment of patients with distal intracranial aneurysms. Materials and methods. The work is based on analysis of data of endovascular treatment among 45 patients with distal cerebral aneurysms in two neurosurgical departments of federal medical centers. Of the 45 analyzed cases 30 were without aneurysm rupture and 15 were with rupture. Results. Endovascular treatment of the distal aneurysms made it possible to achieve good treatment results (4–5 points on the Glasgow Outcome Scale (GOS)) in 97.8 % of cases: 5 points on GOS – in 68.9 %, 4 points on GOS – in 28.4 %. One (2.2 %) fatal outcome was obtained. The most frequent methods of embolization were embolization of aneurysm by coils with stent assistance (37.8 %) and installation of a flow-diverter stent (28.9 %). Embolization with only coils (20 %) or occlusion of parent artery (13.3 %) were used less frequently. In 3 out of 6 patients, the occlusion of parent artery was not planned. Conclusion. Development of endovascular surgery and technical capabilities of performing operations in the distal cerebral arteries has made it possible to form a multidisciplinary approach to choosing the optimal method of shutting off the distal aneurysm from the bloodstream, taking into account the modern possibilities of open surgery. This is especially important for patients in serious condition due to ruptured aneurysm.
背景。由于脑远端动脉瘤的罕见发生,很少有关于血管内治疗的出版物。随着血管内手术技术的进步,远端动脉瘤成功治愈的病例越来越多。的目标。目的:探讨颅内远端动脉瘤患者血管内治疗的技术能力和效果。材料和方法。这项工作是基于对联邦医疗中心两个神经外科的45例脑远端动脉瘤患者的血管内治疗数据的分析。45例动脉瘤无破裂30例,有破裂15例。结果。在97.8%的病例中,血管内治疗远端动脉瘤可以获得良好的治疗效果(Glasgow Outcome Scale, GOS) 4 - 5分),其中GOS 5分占68.9%,GOS 4分占28.4%。有1例(2.2%)死亡。最常见的栓塞方法是支架辅助线圈栓塞动脉瘤(37.8%)和安装分流支架(28.9%)。仅用线圈栓塞(20%)或阻塞母动脉(13.3%)的使用频率较低。6例患者中有3例未计划闭塞母动脉。结论。血管内外科手术的发展以及在大脑远端动脉进行手术的技术能力,使得考虑到现代开放手术的可能性,选择关闭远端动脉瘤与血流的最佳方法成为一种多学科方法。这对于因动脉瘤破裂而病情严重的患者尤其重要。
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引用次数: 0
Experience of stenting of the extracranial part of the internal carotid artery in patients with acute ischemic stroke 急性缺血性脑卒中患者颈内动脉颅外段支架置入术的体会
Pub Date : 2023-10-17 DOI: 10.17650/1683-3295-2023-25-3-17-23
M. Yu. Volodukhin, I. A. Podshivalov, D. R. Khasanova, R. N. Khairullin
Aim. To present the experience of stenting of the extracranial internal carotid artery (ICA) in case of tandem steno-occlusive carotid lesion in the most acute phase of ischemic stroke.Materials and methods. From December 2018 to December 2021, 29 patients with acute ischemic stroke, because of tandem steno-occlusive lesions of the ICA and intracranial arteries, underwent endovascular surgery to restore cerebral blood flow.Results. Successful restoration of cerebral blood flow (according to the mTICI 2b–3 scale) achieved in 22 (75.9 %) patients. Four (13.8 %) patients had stent thrombosis in the early postoperative period. The incidence of symptomatic hemorrhagic transformation observed in 2 (6.9 %) patients. The frequency of a favorable functional outcome (Rankine 0–2) on the 30th day was 20.7 %, mortality – 24.1 %.Conclusion. Stenting of the extracranial ICA in patients with acute ischemic stroke improves the efficiency of restoration of cerebral blood flow. The use of low doses of glycoprotein receptor blockers prevents stent thrombosis in the early period after implantation and does not increase the incidence of symptomatic hemorrhagic complications.
的目标。目的探讨缺血性脑卒中急性期颈动脉狭窄闭塞并发颈动脉支架置入术的临床经验。材料和方法。2018年12月至2021年12月,29例急性缺血性脑卒中患者因ICA和颅内动脉串联狭窄闭塞病变,行血管内手术恢复脑血流。结果。22例(75.9%)患者成功恢复脑血流(根据mTICI 2b-3量表)。4例(13.8%)患者术后早期出现支架血栓形成。2例(6.9%)患者出现症状性出血转化。第30天功能预后良好(Rankine 0-2)的发生率为20.7%,死亡率为24.1%。结论。急性缺血性脑卒中患者颅内外ICA支架植入术可提高脑血流恢复效率。使用低剂量的糖蛋白受体阻滞剂可以防止支架植入后早期血栓形成,并且不会增加有症状的出血性并发症的发生率。
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引用次数: 0
Surgical aspects of classification and neuroimaging characteristics of idiopathic hydrocephalus in adults 成人特发性脑积水的外科分类和神经影像学特征
Pub Date : 2023-10-17 DOI: 10.17650/1683-3295-2023-25-3-43-58
K. V. Shevchenko, V. N. Shimansky, S. V. Tanyashin, V. K. Poshataev, V. V. Karnaukhov, M. V. Kolycheva, K. D. Solozhentseva, Yu. V. Strunina
Background. Hydrocephalus can be developing by a traumatic brain injury, intracranial hemorrhage, tumor, meningitis of congenital malformation of the central nervous system. When the cause of the hydrocephalus is unclear it is supposed as idiopathic hydrocephalus. The most important classification features are the etiology and level of CSF obstruction. The classification was improved and developed with diagnostic and surgical methods simultaneously. Currently, the neurosurgeons have the possibility for usage of various methods and techniques of surgical treatment with their advantages and disadvantages. Systematization of radiological parameters is necessary to make a decision about the type of the surgery. Aim. To analyze and systematize the neuroimaging characteristics of various forms of idiopathic hydrocephalus in adults, to assess the possible classification of idiopathic hydrocephalus. Materials and methods. Between October 2011 and March 2021 290 patients with idiopathic adult hydrocephalus were operated at the N.N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Health of Russia: onset of symptoms in adulthood; no indications of the etiology of hydrocephalus and congenital hydrocephalus. The age of the patients was 50 ± 18.2 (18–85) years. The magnetic resonance images of patients were evaluated for the size of the ventricles, condition of convexital and basal subarachnoid spaces, obstruction of the CSF pathways, and changes in the position of the premamillary membrane, septum pellucidum, the roof of the 3rd ventricle and the tonsils of the cerebellum, the size of the sella turcica, the angle of the corpus callosum. The frequency of each of these parameters is statistically estimated for each form of idiopathic hydrocephalus. Results. Aqueduct stenosis has become the most frequent form of idiopathic hydrocephalus. Hydrocephalus in obstruction of the foramen of Monroe, aqueduct, foramen of Magendie, and cisterns of the posterior cranial fossa was significantly more characteristic of young people ( p <0.05). Hydrocephalus with obstruction of convexital CSF spaces can be called hydrocephalus of the elderly ( p <0.001). Hydrocephalus without verified signs of occlusion CSF pathways occurs equally in all age groups. The FOHR index was significantly more important, and only in case of cisternal obstruction. Enlargement one or both lateral ventricles and flattening of the roof of the 3rd ventricle is characterized for Monro’s foramen obstruction ( p <0.001). The membrane at the outlet of the 4th ventricle and the absence of the “flow void” was typically only for patients with obstruction of the foramen of Magendie ( p <0.001). Ventral dislocation of the premamillary membrane was characteristic of obstruction of the cerebral aqueduct, the foramen of Magendie, and cisterns of the posterior cranial fossa. Compression of the convexital CSF spaces occurred in case of obstruction of the aqueduct, the foramen of Magendie, b
背景。脑积水可由外伤性脑损伤、颅内出血、肿瘤、脑膜炎或中枢神经系统先天性畸形引起。当脑积水病因不明时,假定为特发性脑积水。最重要的分类特征是脑脊液阻塞的病因和程度。随着诊断和手术方法的同步发展,分类得到了改进和发展。目前,神经外科医生有可能使用各种手术治疗方法和技术,各有优缺点。系统化的放射学参数是决定手术类型的必要条件。的目标。分析整理成人各种形式特发性脑积水的神经影像学特征,探讨特发性脑积水的可能分类。材料和方法。2011年10月至2021年3月期间,290名特发性成人脑积水患者在俄罗斯卫生部N.N. Burdenko国家神经外科医学研究中心接受了手术:成年期出现症状;没有迹象表明脑积水和先天性脑积水的病因。患者年龄50±18.2(18-85)岁。对患者的脑室大小、蛛网膜下腔凸面和基底面情况、脑脊液通路阻塞情况、乳突前膜、透明隔、第三脑室顶和小脑扁桃体的位置变化、蝶鞍大小、胼胝体角度等进行磁共振成像评价。每种形式的特发性脑积水的这些参数的频率进行统计估计。结果。导水管狭窄已成为特发性脑积水最常见的形式。门罗孔、输水管、Magendie孔和后颅窝池阻塞的脑积水在年轻人中更为特征性(p <0.05)。脑积水伴脑脊液凸腔阻塞可称为老年脑积水(p <0.001)。脑积水无脑脊液通路闭塞的证实征象在所有年龄组中同样发生。FOHR指数更为重要,且仅在池梗阻的情况下。Monro孔阻塞的特征是一侧或两侧侧脑室增大,第三脑室顶部变平(p <0.001)。第四脑室出口处的膜和“流腔”的缺失通常仅在Magendie孔阻塞的患者中出现(p <0.001)。乳突前膜腹侧脱位的特征是大脑导水管、Magendie孔和颅后窝的贮池阻塞。脑脊液凹腔受压发生在输水管阻塞时,脑脊液凹腔受压发生在Magendie孔,而脑脊液凹腔受压发生在颅后窝-仅在Magendie孔阻塞时发生。第四脑室扩张与后颅窝大孔和脑池阻塞显著相关(p <0.05)。DESH症状与脑脊液凹腔阻塞显著相关(p <0.001)。后窝的池中只有在池阻塞的情况下才发现额外的膜(p <0.001)。小脑扁桃体突出伴门罗孔、脑导水管、Magendie孔梗阻。结论。由于统计分析,在所有类型的脑积水中都发现了一般症状,而在这种疾病的类型中只发现了特定症状的私人症状。该分类逻辑合理,在神经外科和放射学实践中具有良好的应用价值。它允许合理规划诊断评估和治疗患者。现代磁共振成像方案应包括T2扫描(有“流动空洞”)和FIESTA/CISS扫描在所需平面,轴向FLAIR扫描。
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引用次数: 0
Founder of endovascular neurosurgery Fyodor Andreevich Serbinenko (1928–2002). For the 95<sup>th</sup> anniversary of birth 血管内神经外科的创始人Fyodor Andreevich Serbinenko(1928-2002)。对于95&lt; supgt; the &lt;出生纪念日
Pub Date : 2023-10-17 DOI: 10.17650/1683-3295-2023-25-3-10-16
L. B. Likhterman
The author describes the life’s journey of Fyodor Andreevich Serbinenko, the founder of endovascular surgery, creator of a new chapter in the teaching on cerebral blood flow, and shares memories of friendship with this great scientist and beautiful person. F.A. Serbinenko had developed a brand‑new approach to treatment of cerebral vascular pathologies, namely, low‑trauma intravascular reconstructive interventions, as well as a complex of original endovascular operations for severe vascular pathologies, opened the first in the world department of endovascular surgery in Moscow, became the founder of the Russian school of endovascular surgeons. The principles and techniques of intravascular interventions developed by F.A. Serbinenko has been continuously developed and improved by his disciples and followers and are widely used in current clinical practice.
作者描述了血管内外科的创始人、脑血流教学新篇章的创造者费奥多尔·安德烈耶维奇·谢比年科的人生历程,并与这位伟大的科学家和美丽的人分享了友谊的回忆。F.A. Serbinenko开发了一种全新的治疗脑血管疾病的方法,即低创伤血管内重建干预,以及一种复杂的原始血管内手术治疗严重的血管病变,在莫斯科开设了世界上第一个血管内外科,成为俄罗斯血管内外科医生学派的创始人。由F.A. Serbinenko提出的血管内介入的原理和技术被他的弟子和追随者不断发展和改进,并广泛应用于当前的临床实践。
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引用次数: 0
Experience in the Use of Sacral Neuromodulation in Belarus for Neurogenic Urination Disorders: An Algorithm for Surgical Treatment 白俄罗斯使用骶神经调控术治疗神经源性排尿障碍的经验:手术治疗算法
Г.В. Забродец, В.П. Боярчик, Р.Р. Сидорович, С.А. Лихачев, А.В. Строцкий, А.А. Рагузин, Ю.Н. Голец
Цель. Оценить эффективность и безопасность применения крестцовой нейромодуляции (КНМ) у пациентов с нервно-мышечной дисфункцией мочевого пузыря (НМДМП) при патологии спинного мозга. Материалы и методы. Было обследовано в условиях неврологического отделения РНПЦ неврологии и нейрохирургии 22 пациента. Все пациенты прошли предварительное специализированное обследование и консультирование квалифицированным урологом с целью выявления урологических противопоказаний. Результаты. Давность патологии среди пациентов составила 13,4±9,9 года. Травматическая болезнь спинного мозга отмечалась в 14 случаях, врожденный порок развития спинного мозга – в 6 случаях. Описан разработанный алгоритм хирургического лечения пациентов с НМДМП, включающий поэтапное и дифференцированное использование КНМ. 21 из 22 пациентов успешно прошли этап интраоперационной тестовой стимуляции, а 20 – этап послеоперационной тестовой стимуляции. У 12 пациентов наблюдался сопутствующий синдром хронической тазовой боли, который значимо регрессировал от 50 до 100% у всех пациентов на фоне КНМ. Заключение. Разработанный и апробированный алгоритм хирургического лечения пациентов с НМДМП позволяет поэтапно дифференцированно отбирать пациентов вплоть до непосредственной имплантации крестцового нейростимулятора, что значительно снижает вероятность неэффективного применения методики КНМ. Purpose. To evaluate the effectiveness and safety of sacral neuromodulation (SNM) in patients with neuromuscular bladder dysfunction (NMBD) due to spinal cord pathology. Materials and methods. 22 patients were examined in the neurological department of the Republican Scientific and Practical Center for Neurology and Neurosurgery. All patients underwent preliminary specialized examination and consultation by a qualified urologist in order to identify urological contraindications. Results. The duration of pathology among patients was 13.4±9.9 years. Traumatic disease of the spinal cord was noted in 14 cases, congenital malformation of the spinal cord – in 6 cases. The developed algorithm for surgical treatment of patients with NMBD is described, including the staged and differentiated use of SNM. 21 of 22 patients successfully completed the intraoperative test stimulation stage, and 20 successfully completed the postoperative test stimulation stage. In 12 patients, concomitant chronic pelvic pain syndrome was observed, which significantly regressed from 50 to 100% in all patients against the background of SNM. Conclusion. The developed and tested algorithm for the surgical treatment of patients with NMBD allows for a step-by-step differentiated selection of patients up to the direct implantation of a sacral neurostimulator, which significantly reduces the likelihood of ineffective use of the SNM technique.
目的评估骶神经调控(SNM)对脊髓病变神经肌肉性膀胱功能障碍(NMDMP)患者的疗效和安全性。材料与方法。22 名患者在俄罗斯国家医学院神经内科和神经外科接受了检查。所有患者均接受了初步专业检查,并由合格的泌尿科医生进行会诊,以确定是否有泌尿科禁忌症。结果患者的病程为(13.4±9.9)年。脊髓外伤性疾病有 14 例,脊髓先天性畸形有 6 例。本文介绍了为 NMDMP 患者制定的手术治疗算法,包括分阶段和有区别地使用 CNM。22 名患者中有 21 人成功通过了术中测试刺激阶段,20 人通过了术后测试刺激阶段。12 名患者伴有慢性盆腔疼痛综合征,所有患者的慢性盆腔疼痛综合征在接受 CNM 治疗后均有明显缓解,缓解率从 50%到 100%不等。结论已开发并经过测试的 NMDMP 患者手术治疗算法可以逐步区分选择患者,直至直接植入骶神经刺激器,从而大大降低了 CNM 技术无效应用的概率。 目的评估骶神经调控(SNM)在脊髓病变导致的神经肌肉性膀胱功能障碍(NMBD)患者中的有效性和安全性。材料和方法。22 名患者在共和国神经学和神经外科科学实践中心的神经科接受了检查。所有患者均接受了初步专业检查,并由合格的泌尿科医生进行会诊,以确定是否有泌尿科禁忌症。研究结果患者的病程为 13.4±9.9 年。脊髓外伤性疾病有 14 例,脊髓先天性畸形有 6 例。本文介绍了为 NMBD 患者制定的手术治疗算法,包括分阶段和有区别地使用 SNM。22 例患者中有 21 例成功完成了术中测试刺激阶段,20 例成功完成了术后测试刺激阶段。在 12 例患者中观察到伴有慢性盆腔疼痛综合征,在使用 SNM 的背景下,所有患者的慢性盆腔疼痛综合征均明显缓解,缓解率从 50% 到 100% 不等。结论针对 NMBD 患者的手术治疗所开发和测试的算法可以逐步区分选择患者,直至直接植入骶神经刺激器,从而大大降低了 SNM 技术无效的可能性。
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引用次数: 0
Transcranial Electroanalgesia as an Auxiliary Treatment for Chronic Migraine with Medication Abuse 经颅电镇痛作为药物滥用型慢性偏头痛的辅助治疗方法
Т.Н. Чернуха, С.А. Лихачев, О.В. Глеб, Г.В. Зобнина
Цель. Оценить результаты комплексного лечения хронической мигрени (ХМ) в сочетании с лекарственно-индуцированной головной болью (ЛИГБ) с использованием метода транскраниальной электроанальгезии (ТЭА). Материалы и методы. В основную группу вошел 61 пациент с ХМ в сочетании с ЛИГБ. 31 пациент получал стандартную терапию согласно клиническим протоколам и курс ТЭА. Контрольную группу составили 30 пациентов, получавших стандартную терапию. Все пациенты самостоятельно заполняли дневники головной боли в течение как минимум одного месяца, указывали интенсивность головной боли по визуальной аналоговой шкале (ВАШ). Также применялся Headache Impact Test (индекс HIT-6) с определением четырех степеней воздействия на повседневную активность и Лидский опросник зависимости (ЛОЗ) – Leeds Dependence Questionnaire (LDQ) до и после курса лечения. Для транскраниальной электротерапии использовался прибор «Радиус-01 Кранио» (Россия). Результаты. При оценке эффективности лечения в основной и контрольной группе методом множественного регрессионного анализа установлено достоверное снижение дней головной боли в месяц в исследуемой группе, снижение интенсивности по ВАШ и отсутствие влияния включения в комплексную терапию ТЭА на количество приступов головной боли (Multiple R=0,714, р=0,02). Таким образом, полученные данные позволяют сделать вывод о положительном влиянии ТЭА на ЛИГБ при ХМ. Заключение. Назначение методики электроанальгезии у пациентов с ХМ более предпочтительно при наличии ЛИГБ. ТЭА может быть рекомендована к более широкому применению у пациентов с ХМ, отягощенной ЛИГБ, в повседневной практике. Purpose. To evaluate the results of complex treatment of chronic migraine (CM) in combination with medication-overuse headache (MOH) using the method of transcranial electroanalgesia (TEA). Materials and methods. The study group included 61 patients with CM in combination with DIH. 31 patients received standard therapy, according to clinical protocols, and a course of TEA. The control group consisted of 30 patients who received standard therapy. All patients self-completed headache diaries for at least one month, indicating the intensity of headache on a visual analogue scale (VAS). The Headache Impact Test (HIT-6 index) with four levels of impact on daily activities and the Leeds Dependence Questionnaire (LDQ) were also assessed before and after treatment. The device "Radius-01 Cranio" (Russia) was used for transcranial electrotherapy. Results. The method of multiple regression analysis revealed a significant decrease in headache days per month in the study group, a decrease in intensity according to the VAS scale, and no effect of including TEA in complex therapy on the number of headache attacks (Multiple R=0.714, p=0.02). Thus, the data obtained allow us to conclude that TEA has a positive effect on DIH in CM. Conclusion. The appointment of electroanalgesia technique in patients with CM is more preferable in the presence of DIH. TEA may be recommended for wider us
目的评估使用经颅电镇痛(TEA)对慢性偏头痛(CM)合并药物性头痛(LIGB)进行综合治疗的效果。材料与方法。主要研究组包括 61 名 HM 合并 LIGB 患者。31 名患者根据临床方案和 TEA 疗程接受标准治疗。对照组包括 30 名接受标准治疗的患者。所有患者都独立填写了至少一个月的头痛日记,并用视觉模拟量表(VAS)显示头痛强度。此外,治疗前后还使用了头痛影响测试(HIT-6 指数)和利兹依赖性问卷(LDQ)。经颅电疗使用了 Radius-01 Cranio(俄罗斯)设备。研究结果通过多元回归分析法评估主要组和对照组的疗效时发现,研究组每月头痛天数显著减少,根据 VAS 测量的头痛强度降低,而在复合疗法中加入 TEA 对头痛发作次数没有影响(多重 R=0,714,P=0,02)。因此,根据所获得的数据,我们可以得出结论:TEA 对中医 LIGB 有积极影响。结论在存在 LIGB 的情况下,对 XM 患者处方电镇痛技术更为可取。建议在常规治疗中将 TEA 更广泛地用于伴有 LIGB 的 CM 患者。 目的评估使用经颅电镇痛(TEA)方法对慢性偏头痛(CM)合并药物滥用性头痛(MOH)进行综合治疗的效果。材料和方法研究组包括61名合并DIH的慢性偏头痛患者。31 名患者根据临床方案接受了标准治疗和一个疗程的 TEA。对照组包括 30 名接受标准疗法的患者。所有患者均自行填写了至少一个月的头痛日记,并用视觉模拟量表(VAS)显示头痛的强度。治疗前后还进行了头痛影响测试(HIT-6 指数)(包括对日常活动影响的四个等级)和利兹依赖性问卷(LDQ)的评估。经颅电疗使用了 "Radius-01 Cranio"(俄罗斯)设备。结果显示多元回归分析法显示,研究组每月头痛天数显著减少,根据 VAS 量表,头痛强度也有所降低,而将 TEA 纳入复合疗法对头痛发作次数没有影响(多重 R=0.714,P=0.02)。因此,根据所获得的数据,我们可以得出结论:TEA 对 CM 的 DIH 有积极作用。结论在存在DIH的情况下,对CM患者使用电镇痛技术更为可取。在日常实践中,建议将 TEA 更广泛地应用于因 MOH 而病情加重的 CM 患者。
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引用次数: 0
Botulinotherapy of Neurological Disorders in Children with Klippel-Feil Syndrome: A Case Report 针对克利珀尔-费尔综合征患儿神经紊乱的肉毒杆菌疗法:病例报告
Александр Николаевич Яковлев, Л.В. Шалькевич, Т.Н. Чернуха, А.К. Сташков, А.А. Мелюкова, М.В. Гаманицкая, К.О. Гирис
Синдром Клиппеля – Фейля (СКФ) представляет собой врожденный порок развития позвоночника (преимущественно шейных и верхнегрудных позвонков) в виде их аномального сращения, нарушения деления или физиологической сегментации. Развитие синдрома Клиппеля – Фейля преимущественно ассоциировано с генетическими мутациями в следующих генах: GDF6, GDF3, MEOX1, MYO18B, RIPPLY2, BAZ1B, FREM2, SUFU, VANGL1, KMT2D. Клинически синдром проявляется мультисистемной патологией, среди которой ведущие симптомы представлены неврологическими нарушениями. В статье приводится опыт off-lable-терапии ботулиническим токсином типа А рефлекторно-тонического и болевого синдромов у ребенка вследствие СКФ. Проведенная ботулинотерапия в раннем постинъекционном периоде привела к оптимизации мышечного тонуса мышц-мишеней – musculus trapezius и musculus levator scapulae с обеих сторон, увеличению активных и пассивных движений головы, снижению выраженности болевого синдрома. Таким образом, ботулинотерапия при СКФ может использоваться для повышения качества жизни пациентов, профилактики соединительнотканного перерождения вовлеченных в патологический процесс мышц, может позволить отсрочить оперативное вмешательство или избежать его использования. Klippel-Feil syndrome is a congenital malformation of the spine (mainly the cervical and upper thoracic vertebrae), in the form of their abnormal fusion, division disorders or physiological segmentation. Emergence of KFS is mostly associated with genetic mutations in following genes: GDF6, GDF3, MEOX1, MYO18B, RIPPLY2, BAZ1B, FREM2, SUFU, VANGL1, KMT2D. Clinically, the syndrome is manifested by multisystem pathology in which the leading symptoms belong to neurological disorders. The article presents the experience of off-lable therapy with botulinum toxin type A (BTA) reflex-tonic and pain syndrome in a child due to KFS. The botulinum toxin therapy performed in the early post-injection period led to the optimization of the muscle tone of the target muscles: musculus trapezius and musculus levator scapulae on both sides, an increase in active and passive head movements, and a decrease in the severity of pain syndrome. Therefore, botulinum toxin therapy in the case of KFS can be used for increasing patient life quality, prevention of connective tissue muscles degeneration and can allow to delay or avoid surgery.
克利珀尔-费尔综合征(Klippel-Feil Syndrome,KFS)是一种脊柱(主要是颈椎和上胸椎)先天性畸形,表现为异常融合、分裂或生理分节。克利珀尔-费尔综合征的发病主要与以下基因的基因突变有关:GDF6、GDF3、MEOX1、MYO18B、RIPPLY2、BAZ1B、FREM2、SUFU、VANGL1、KMT2D。临床上,该综合征表现为多系统病变,其中主要症状是神经系统疾病。文章介绍了用A型肉毒毒素治疗一名患儿因SUFU引起的反射音和疼痛综合征的经验。注射后早期的肉毒杆菌治疗可优化目标肌肉(两侧斜方肌和肩胛提肌)的肌张力,增加头部的主动和被动运动,并减轻疼痛综合征的严重程度。因此,肉毒杆菌疗法可用于改善 SCF 患者的生活质量,预防病理过程中肌肉结缔组织变性,推迟手术干预或避免使用手术干预。 克利珀尔-费尔综合征(Klippel-Feil Syndrome)是一种脊柱(主要是颈椎和上胸椎)先天性畸形,表现为脊柱异常融合、分裂紊乱或生理分节。KFS 的出现主要与以下基因的基因突变有关:GDF6、GDF3、MEOX1、MYO18B、RIPPLY2、BAZ1B、FREM2、SUFU、VANGL1、KMT2D。临床上,该综合征表现为多系统病变,其中主要症状属于神经系统疾病。本文介绍了一名 KFS 患儿的 A 型肉毒杆菌毒素(BTA)反射-张力和疼痛综合征脱机治疗经验。在注射后早期进行的肉毒毒素治疗优化了目标肌肉(两侧斜方肌和肩胛提肌)的肌张力,增加了头部的主动和被动运动,并降低了疼痛综合征的严重程度。因此,肉毒杆菌毒素疗法可用于提高 KFS 患者的生活质量,防止结缔组织肌肉退化,并可推迟或避免手术。
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引用次数: 0
Legal Regulation of Information Relations when Creating a Database of Medical Research for Neurological and Neurosurgical Patients 建立神经系统和神经外科患者医学研究数据库时信息关系的法律规范
А.В. Белецкий, Т.В. Жукова, С.А. Лихачев, Ю.Г. Шанько, А.В. Борисов, С.М. Полякова, К.А. Самочерных, Н.Е. Иванова, Ю.М. Забродская
Введение. База данных – это упорядоченный набор структурированных информативных данных, представленных для хранения в электронных файлах в системе компьютера. Эти данные легко управляемы, изменяемы, легко обновляются, контролируются и упорядочиваются. В большинстве своем базы данных для проведения записи и запросов данных используют языки для структурирования. Цель. Изучение отдельных проблем формирования базы данных для проведения медицинских исследований в сфере неврологии и нейрохирургии с учетом особенностей сохранения личной информации, а также поиск подхода к объединению общих прикладных понятий для проведения совместных научных исследований в России и Республике Беларусь. Материалы и методы. Изучены отдельные проблемы, оказывающие влияние на формирование понятия базы данных, с целью проведения медицинских исследований в сфере неврологии и нейрохирургии с учетом особенностей сохранения личных данных пациентов. Методологической основой исследования являются общенаучный метод, метод формальной логики и системного анализа, синтез, индукция, метод описания и сравнения. Результаты. Понятие «персональные данные» впервые зафиксировал Закон «Об информации, информатизации и защите информации» (абз. 24 ст. 1 Закона «Об информации, информатизации и защите информации» в Республике Беларусь и Федеральный закон «Об информации, информационных технологиях и о защите информации» от 27.07.2006 № 149-ФЗ в России). Защита информации о частной жизни физического лица и персональных данных этими законами как в Беларуси, так и в России рассматривается как принцип правового регулирования информационных отношений (абз. 5 ст. 4 Закона «Об информации, информатизации и защите информации» Республики Беларусь, а также ст. 5 Федерального закона «Об информации, информационных технологиях и о защите информации» от 27.07.2006 № 149-ФЗ в последней редакции), а сохранение и неразглашение персональных данных – как цель защиты информации (абз. 3 ст. 27 Закона «Об информации, информатизации и защите информации» Республики Беларусь и последняя редакция Федерального закона «Об информации, информационных технологиях и о защите информации» от 27.07.2006 № 149-ФЗ, статья 3 «Принципы правового регулирования отношений в сфере информации, информационных технологий и защиты информации»). Согласие субъекта персональных данных на обработку специальных персональных данных не требуется, если действие производится в целях организации оказания медицинской помощи. Однако должно быть соблюдено условие, что такие персональные данные обрабатываются медицинским, фармацевтическим или иным работником здравоохранения, на которого возложены обязанности по обеспечению защиты персональных данных. Учитывая наличие множества особенностей в конкретной отрасли медицины, должна учитываться совокупность факторов. Одно из главных требований состоит в том, что обработка персональных данных должна ограничиваться достижением заранее заявленных конкретных целей. Одной из особенностей обследования пациентов с невроло
引言数据库是一组有序的结构化信息数据,以电子文档的形式存储在计算机系统中。这些数据易于管理、修改、更新、控制和组织。数据库大多使用结构化语言来进行数据记录和查询。目的考虑到个人信息保存的特殊性,研究神经学和神经外科领域医学研究数据库建立的一些问题,并找到一种方法来统一俄罗斯和白俄罗斯共和国联合科学研究的共同应用概念。材料与方法。为了在神经学和神经外科领域开展医学研究,同时考虑到保存患者个人信息的特殊性,对影响数据库概念形成的个别问题进行了研究。研究的方法论基础是一般科学方法、形式逻辑和系统分析方法、综合法、归纳法、描述和比较法。研究结果信息、信息化和信息保护法》首先确定了 "个人数据 "的概念(《信息、信息化和信息保护 法》第 24 条第 1 款)。白俄罗斯共和国《信息、信息化和信息保护法》第 24 条第 1 款和俄罗斯 2006 年 7 月 27 日第 149-FZ 号联邦法《信息、信息技术和信息保护法》)。白俄罗斯和俄罗斯的这些法律都将保护个人私生活信息和个人数据视为信息关系法律规范的原则 (《信息权法》第 4 条第 5 款)。白俄罗斯共和国《信息、信息化和信息保护法》第 4 条第 5 款,以及 2006 年 7 月 27 日第 149-FZ 号联邦法《信息、信息技术和信息保护法》(最新版本)第 5 条),并将保护和不披露个人数据作为信息保护的目标(白俄罗斯《信息、信息化和信息保护法》第 27 条第 3 款)。白俄罗斯共和国《信息、信息化和信息保护法》第 27 条第 3 款和 2006 年 7 月 27 日第 149-FZ 号《信息、信息技术和信息保护联邦法》最新版本第 3 条 "信息、信息技术和信息保护领域关系的法律调节原则")。如果处理特殊个人资料的目的是为了组织提供医疗服务,则无需征得个人资料主体的同意。然而,必须满足的条件是,这些个人资料是由负责确保个人资料得到保护的医务人员、药剂师或其他医护人员处理的。鉴于某一医学分支有许多特殊性,必须综合考虑各种因素。其中一项主要要求是,个人数据的处理必须仅限于实现事先说明的特定目的。神经系统病理检查和神经外科病理检查的特殊性之一是使用与活组织检查相关的方法,这些方法在创建数据库时具有输入的特殊性。结论医疗机构的主要信息资源之一是其自动化企业数据库,其中包括患者病历信息、为患者提供的医疗服务的数量和性质数据。由于目前处理的信息量不断增加,数据库被广泛应用于医学的各个领域,其目的也完全不同,因此,在创建医学研究数据库时,需要对信息关系进行法律规范,这将是创建国家间联合项目科学能力的起点,也是我们这个时代的新现实。 引言。数据库是一组有序的结构化信息数据,用于存储在计算机系统的电子文档中。这些数据易于管理、更改、更新、控制和组织。数据库大多使用结构化语言来记录和查询数据。目的。研究在神经学和神经外科领域进行医学研究时建立数据库的个别问题,同时考虑到保存个人信息的特殊性,以及找到一种方法,将共同的应用概念结合起来,在俄罗斯和白俄罗斯共和国开展联合科学研究。材料和方法。考虑到保存患者个人信息的特殊性,研究了影响神经学和神经外科医学研究数据库概念形成的一些问题。
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Неврология и нейрохирургия. Восточная Европа
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