Pub Date : 2024-01-21DOI: 10.37311/jsscr.v6i1.9077
Mohamad Adam Mustapa, Ariani H. Hutuba, Dizky Ramadani Putri Papeo, Wiwit Zuriati Uno
Body lotion is a skincare cosmetics products that usually contain preservatives as inhibitors of bacteria and fungi growth. According to the Food and Drug Supervisory Agency of Indonesian Republic, 2011: HK.03.1.23.08.11.07517, in which the preservative levels of nipagin (methyl paraben) in a body lotion must be 0.4%, Preservative level over 0.4% may result in skin irritation and allergic reactions. The purpose of this study was to determine the nipagin’s essence and levels in body lotions sold in Gorontalo City. Nipagin’s identification was carried out with a qualitative analysis using Thin Layer Chromatography and color change using 2% of deniges reactor and sodium nitrite, while the quantitative analysis was carried out with spectrophotometry UV-Vis at 258 nm wavelength that was previously extracted with 96% of ethanol solvent. The results of the qualitative study show that four (A, D, E, and F) out of six samples of body lotions: A, B, C, D, E, and F contained preservatives. Quantitatively, the levels of nipagin) on the four samples are sequentially shown as follows: by A:0.38%, D:0.04%, E:0.14%, F:0.14%. All in all, the samples are entirely eligible according to the Regulotions of the National Agency of Drug and Food of Indonesian Republic 2011: HK.03.1.23.08.11.07517.
{"title":"Penetapan kadar Nipagin (Methyl Paraben) pada body lotion yang beredar di Kota Gorontalo secara Spektrofotometri UV-Vis","authors":"Mohamad Adam Mustapa, Ariani H. Hutuba, Dizky Ramadani Putri Papeo, Wiwit Zuriati Uno","doi":"10.37311/jsscr.v6i1.9077","DOIUrl":"https://doi.org/10.37311/jsscr.v6i1.9077","url":null,"abstract":"Body lotion is a skincare cosmetics products that usually contain preservatives as inhibitors of bacteria and fungi growth. According to the Food and Drug Supervisory Agency of Indonesian Republic, 2011: HK.03.1.23.08.11.07517, in which the preservative levels of nipagin (methyl paraben) in a body lotion must be 0.4%, Preservative level over 0.4% may result in skin irritation and allergic reactions. The purpose of this study was to determine the nipagin’s essence and levels in body lotions sold in Gorontalo City. Nipagin’s identification was carried out with a qualitative analysis using Thin Layer Chromatography and color change using 2% of deniges reactor and sodium nitrite, while the quantitative analysis was carried out with spectrophotometry UV-Vis at 258 nm wavelength that was previously extracted with 96% of ethanol solvent. The results of the qualitative study show that four (A, D, E, and F) out of six samples of body lotions: A, B, C, D, E, and F contained preservatives. Quantitatively, the levels of nipagin) on the four samples are sequentially shown as follows: by A:0.38%, D:0.04%, E:0.14%, F:0.14%. All in all, the samples are entirely eligible according to the Regulotions of the National Agency of Drug and Food of Indonesian Republic 2011: HK.03.1.23.08.11.07517.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"218 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140501285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-21DOI: 10.37311/jsscr.v6i1.15546
A. A. Andy Suryadi, Mahdalena Sy. Pakaya, Mohamad Adam Mustapa, A.Takdir Makkulawu, Faramita Hiola
The island plant (Alstonia scholaris) is one of the plants that is often used for traditional medicinePulai plant (Alstonia scholaris L.) is often used as a traditional medicine to treat fever, itch, malaria, and diarrhea. The secondary metabolite compounds obtained from this plant are flavonoid, tannin, and steroid. This study aims to determine the specific and non-specific parameters and the total flavonoid levels of Pulai's 70% ethanol extract. The standardization of medicine plant extract is needed as an effort to traditional medicine quality control. The standardization test result for specific parameter showed that the organoleptic extract was a dark green and thick extract, bitter, and had a distinctive smell, containing water soluble content (20.14% ±0.1649) and ethanol soluble content (9.495%±0.0928). The standardization for non-specific parameter showed water content (9.17%±0.02055), total ash content (1.76%±0.00547), acid insoluble ash content (2.82%±0.01257), and drying shrinkage (5.08%± 0.04636). Meanwhile, the analysis of flavonoid level of Pulai's 70% ethanol extract fraction was done at the wavelength of 438.36 nm and the absorbance value of 0.0011. The total flavonoid content was analyzed using quercetin standard linear equation of y=0.0643x + (-0.0232) with the correlational coefficient (R)- 0.9974, and the total flavonoid content of 3.77%.
{"title":"Standarisasi dan Analisis Kandungan Flavonoid Total Daun Pulai (Alstonia shcolaris L.)","authors":"A. A. Andy Suryadi, Mahdalena Sy. Pakaya, Mohamad Adam Mustapa, A.Takdir Makkulawu, Faramita Hiola","doi":"10.37311/jsscr.v6i1.15546","DOIUrl":"https://doi.org/10.37311/jsscr.v6i1.15546","url":null,"abstract":"The island plant (Alstonia scholaris) is one of the plants that is often used for traditional medicinePulai plant (Alstonia scholaris L.) is often used as a traditional medicine to treat fever, itch, malaria, and diarrhea. The secondary metabolite compounds obtained from this plant are flavonoid, tannin, and steroid. This study aims to determine the specific and non-specific parameters and the total flavonoid levels of Pulai's 70% ethanol extract. The standardization of medicine plant extract is needed as an effort to traditional medicine quality control. The standardization test result for specific parameter showed that the organoleptic extract was a dark green and thick extract, bitter, and had a distinctive smell, containing water soluble content (20.14% ±0.1649) and ethanol soluble content (9.495%±0.0928). The standardization for non-specific parameter showed water content (9.17%±0.02055), total ash content (1.76%±0.00547), acid insoluble ash content (2.82%±0.01257), and drying shrinkage (5.08%± 0.04636). Meanwhile, the analysis of flavonoid level of Pulai's 70% ethanol extract fraction was done at the wavelength of 438.36 nm and the absorbance value of 0.0011. The total flavonoid content was analyzed using quercetin standard linear equation of y=0.0643x + (-0.0232) with the correlational coefficient (R)- 0.9974, and the total flavonoid content of 3.77%.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"131 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140501273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-21DOI: 10.37311/jsscr.v6i1.20256
Hamsidar Hasan, Faramita Hiola, Mahdalena Sy. Pakaya, Juliyanti Akuba, Muhammad Andre Viswanathan Maaruf
Bellyache Bush (Jatropha gossypiifolia) is a plant registered as one of the plants withvarious medical properties due to its Flavonoids, Alkaloids, Tannins, and Terpenoids. Bellyache Bush plays a significant role in accelerating wound healing and cell regeneration. This research aims to determine the effectiveness of the ethyl acetate fraction from Bellyache Bush leaves (Jatropha gossypiifolia) on male mice (Mus musculus). Bellyache Bush leaves was extracted using a multistage maceration method using n-hexane and ethyl acetate as solvents. This effectiveness of incision wound healing was tested by divided the test animals into five experimental groups, and each consisting of 3 male mice. All mice were treated according to their respective experimental groups : Group 1 (negative control), Group 2 (positive control with 10% povidone iodine), Group 3 (5% Bellyache Bush extract), Group 4 (10% Bellyache Bush extract), Group 5 (15% Bellyache Bush extract), until the wounds healed or white scar tissue was observed. The results indicate that at a concentration of 15% the ethyl acetate fraction of Bellyache Bush extract was more effective compared to the positive control, povidine iodine.
{"title":"Penapisan Fitokimia dan Efek Penyembuhan Luka Insisi Daun Jarak Merah (Jatropha gossypiifolia) pada Mencit (Mus musculus)","authors":"Hamsidar Hasan, Faramita Hiola, Mahdalena Sy. Pakaya, Juliyanti Akuba, Muhammad Andre Viswanathan Maaruf","doi":"10.37311/jsscr.v6i1.20256","DOIUrl":"https://doi.org/10.37311/jsscr.v6i1.20256","url":null,"abstract":"Bellyache Bush (Jatropha gossypiifolia) is a plant registered as one of the plants withvarious medical properties due to its Flavonoids, Alkaloids, Tannins, and Terpenoids. Bellyache Bush plays a significant role in accelerating wound healing and cell regeneration. This research aims to determine the effectiveness of the ethyl acetate fraction from Bellyache Bush leaves (Jatropha gossypiifolia) on male mice (Mus musculus). Bellyache Bush leaves was extracted using a multistage maceration method using n-hexane and ethyl acetate as solvents. This effectiveness of incision wound healing was tested by divided the test animals into five experimental groups, and each consisting of 3 male mice. All mice were treated according to their respective experimental groups : Group 1 (negative control), Group 2 (positive control with 10% povidone iodine), Group 3 (5% Bellyache Bush extract), Group 4 (10% Bellyache Bush extract), Group 5 (15% Bellyache Bush extract), until the wounds healed or white scar tissue was observed. The results indicate that at a concentration of 15% the ethyl acetate fraction of Bellyache Bush extract was more effective compared to the positive control, povidine iodine.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"19 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140501398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-21DOI: 10.37311/jsscr.v6i1.20384
N. Thomas, M. Taupik, Fika Nuzul Ramadhani, Ariani H. Hutuba, Dizky Ramadani Putri Papeo
Bromelain is a proteolytic enzyme or natural protease found in tissues, including the stem, fruit, and leaves of pineapple (Ananas comosus var. comosus) and other plant species of the Bromeliaceae family. Bromelain is known as an efficient debdriding agent because it is beneficial in burn healing and tissue regeneration. This research aims to determine the effectiveness of bromelain enzyme for burns wounds in rabbits (Oryctolagus cuniculus). This research began with the optimization of carbopol 940 base preparations with variations in concentration, namely Formula 1 (F1) for 0,5%, Formula 2 (F2) for 1%, and Formula 3 (F3) for 1,5%. The evaluation of the gel formulation includes an organoleptic test, homogeneity test, pH test, viscosity test, adhesive force test, and spreadability test. The evaluation result indicates the base concentration in Formula 1 (F1) at 0,5% has met the requirements for a gel preparation. Formula 1 (F1) for 0,5, then combined with varying concentration of bromelain, namely Formula 1A (0,1%), Formula 1B (0,5%), and Formula 1C (1%). The gel formulation wa re-evaluated, including an organoleptic test, homogeneity test, pH test, viscosity test, adhesion test, spreadability test, irritation test, and in vivo test. In vivo effectiveness testing and irritation testing were conducted on five treatment groups, namely a positive control group (Bioplacenton®), Formula 1A (0,1%), Formula 1B (0,5%), Formula 1C (1%), and a group without treatment, then observed for 15 days. The observation data were processed using the One Way ANOVA test. Based on the results of the irritation test, Formula 1A (0,1%). Formula 1B (0,5%) and Formula 1C (1%) did not cause skin irritation. In the in vivo test, Formula 1C (1%) indicated the fastest recovery compared to other treatment groups, as evidenced by the decrease in wound diameter and visual observation, where the wound had started to close completely on day 15 of observation.
{"title":"Penyembuhan Luka Bakar Gel Enzim Bromelin Secara In Vivo","authors":"N. Thomas, M. Taupik, Fika Nuzul Ramadhani, Ariani H. Hutuba, Dizky Ramadani Putri Papeo","doi":"10.37311/jsscr.v6i1.20384","DOIUrl":"https://doi.org/10.37311/jsscr.v6i1.20384","url":null,"abstract":"Bromelain is a proteolytic enzyme or natural protease found in tissues, including the stem, fruit, and leaves of pineapple (Ananas comosus var. comosus) and other plant species of the Bromeliaceae family. Bromelain is known as an efficient debdriding agent because it is beneficial in burn healing and tissue regeneration. This research aims to determine the effectiveness of bromelain enzyme for burns wounds in rabbits (Oryctolagus cuniculus). This research began with the optimization of carbopol 940 base preparations with variations in concentration, namely Formula 1 (F1) for 0,5%, Formula 2 (F2) for 1%, and Formula 3 (F3) for 1,5%. The evaluation of the gel formulation includes an organoleptic test, homogeneity test, pH test, viscosity test, adhesive force test, and spreadability test. The evaluation result indicates the base concentration in Formula 1 (F1) at 0,5% has met the requirements for a gel preparation. Formula 1 (F1) for 0,5, then combined with varying concentration of bromelain, namely Formula 1A (0,1%), Formula 1B (0,5%), and Formula 1C (1%). The gel formulation wa re-evaluated, including an organoleptic test, homogeneity test, pH test, viscosity test, adhesion test, spreadability test, irritation test, and in vivo test. In vivo effectiveness testing and irritation testing were conducted on five treatment groups, namely a positive control group (Bioplacenton®), Formula 1A (0,1%), Formula 1B (0,5%), Formula 1C (1%), and a group without treatment, then observed for 15 days. The observation data were processed using the One Way ANOVA test. Based on the results of the irritation test, Formula 1A (0,1%). Formula 1B (0,5%) and Formula 1C (1%) did not cause skin irritation. In the in vivo test, Formula 1C (1%) indicated the fastest recovery compared to other treatment groups, as evidenced by the decrease in wound diameter and visual observation, where the wound had started to close completely on day 15 of observation.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"110 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140501131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-19DOI: 10.37311/jsscr.v6i1.23785
Madania Madania, W. Abdulkadir, E. Djuwarno, A. Suryadi, Sherina Sherina
Hypertension is a condition that can affect pregnancy. High blood pressure during pregnancy can hinder fetal and uterine growth, lead to fetal death in the womb, and result in premature birth. These complications can be minimized with appropriate antihypertensive therapy. The objective of this study is to determine the incidence rate, management, and accuracy of antihypertensive treatment according to the reference standards of the 2016 Preeclampsia National Medical Service Guidelines (PNPK). This research was an observational descriptive study where the data obtained were secondary data collected retrospectively from medical records at Regional Public Hospital of Toto Kabila from September 2022 to May 2023. The sample was taken using a saturated sampling technique, so the sample in this study included all pregnant women diagnosed with preeclampsia. The results of the study obtained 65 patients, consisting of 36 severe preeclampsia patients and 29 mild preeclampsia patients. The study showed that hypertension in pregnant women was often found in the age group of 26-35 years, with 25 patients (39%), and in the third trimester of pregnancy, with 23 cases, while 2 experienced hypertension in the first trimester. 12 patients were diagnosed with severe preeclampsia and 13 patients with mild preeclampsia. The treatment of hypertension in pregnant women for mild preeclampsia included methyldopa (34%) and nifedipine (7%). For severe preeclampsia, single therapy included methyldopa (39%), amlodipine (8%), and combination therapy such as nifedipine + methyldopa (36%) and methyldopa + amlodipine (17%). The accuracy of antihypertensive drug use in pregnant women based on the 2016 Preeclampsia PNPK was 86%, including appropriate indications, correct drugs and correct doses.
{"title":"Studi Penatalaksanaan dan Ketepatan Pengobatan Antihipertensi pada Wanita Hamil di RSUD Toto Kabila","authors":"Madania Madania, W. Abdulkadir, E. Djuwarno, A. Suryadi, Sherina Sherina","doi":"10.37311/jsscr.v6i1.23785","DOIUrl":"https://doi.org/10.37311/jsscr.v6i1.23785","url":null,"abstract":"Hypertension is a condition that can affect pregnancy. High blood pressure during pregnancy can hinder fetal and uterine growth, lead to fetal death in the womb, and result in premature birth. These complications can be minimized with appropriate antihypertensive therapy. The objective of this study is to determine the incidence rate, management, and accuracy of antihypertensive treatment according to the reference standards of the 2016 Preeclampsia National Medical Service Guidelines (PNPK). This research was an observational descriptive study where the data obtained were secondary data collected retrospectively from medical records at Regional Public Hospital of Toto Kabila from September 2022 to May 2023. The sample was taken using a saturated sampling technique, so the sample in this study included all pregnant women diagnosed with preeclampsia. The results of the study obtained 65 patients, consisting of 36 severe preeclampsia patients and 29 mild preeclampsia patients. The study showed that hypertension in pregnant women was often found in the age group of 26-35 years, with 25 patients (39%), and in the third trimester of pregnancy, with 23 cases, while 2 experienced hypertension in the first trimester. 12 patients were diagnosed with severe preeclampsia and 13 patients with mild preeclampsia. The treatment of hypertension in pregnant women for mild preeclampsia included methyldopa (34%) and nifedipine (7%). For severe preeclampsia, single therapy included methyldopa (39%), amlodipine (8%), and combination therapy such as nifedipine + methyldopa (36%) and methyldopa + amlodipine (17%). The accuracy of antihypertensive drug use in pregnant women based on the 2016 Preeclampsia PNPK was 86%, including appropriate indications, correct drugs and correct doses.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"396 1-6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140502471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-19DOI: 10.37311/jsscr.v6i1.21376
Widy Susanti Abdulkadir, Endah Nurrhohwinta Djuwarno, Sukmawati A. Damiti
Diabetes mellitus is a disorder of blood sugar metabolism chronically characterized by high blood sugar levels resulting from impaired insulin secretion, insulin resistance, or both. Treatment of diabetes mellitus consists of four pillars: education, medical nutrition therapy (MNT), and physical and pharmacological therapies. One of the plants that can be used as a medicinal ingredient is guava leaves. Guava (Psidium guajava L.) leaves are a group of herbal plants with a chemical content that is good for health. Therefore, guava (Psidium guajava L.) leaves are plants that are efficacious as medicine. This plant contains secondary metabolites that act as antidiabetics. Thus, the research aimed to determine the effectiveness of ethanol extract of guava (Psidium guajava L.) leaves on the decrease in blood sugar levels in male mice. The research method employed was maceration, phytochemical screening, and antidiabetic testing with the pre-test and post-test control group design methods to determine if there was a decrease after administration of the extract. The findings indicated that the phytochemical screening test found that guava (Psidium guajava L.) contained secondary metabolites, including alkaloids, flavonoids, and tannins. In contrast, the antidiabetic test revealed that three extracts with concentrations of 50 mg, 100 mg. and 200 mg could decrease blood sugar levels by 15%, 21%, and 47%, respectively. From these findings, it can be concluded that antidiabetic compounds which play a role in the ellanol extrict of guava (Psidium guajava L.) leaves are alkaloids, flavonoids, and tannins.
{"title":"Uji Efektivitas Ekstrak Daun Jambu Biji (Psidium guajava) dalam Menurunkan Kadar Gula Darah Mencit (Mus musculus)","authors":"Widy Susanti Abdulkadir, Endah Nurrhohwinta Djuwarno, Sukmawati A. Damiti","doi":"10.37311/jsscr.v6i1.21376","DOIUrl":"https://doi.org/10.37311/jsscr.v6i1.21376","url":null,"abstract":"Diabetes mellitus is a disorder of blood sugar metabolism chronically characterized by high blood sugar levels resulting from impaired insulin secretion, insulin resistance, or both. Treatment of diabetes mellitus consists of four pillars: education, medical nutrition therapy (MNT), and physical and pharmacological therapies. One of the plants that can be used as a medicinal ingredient is guava leaves. Guava (Psidium guajava L.) leaves are a group of herbal plants with a chemical content that is good for health. Therefore, guava (Psidium guajava L.) leaves are plants that are efficacious as medicine. This plant contains secondary metabolites that act as antidiabetics. Thus, the research aimed to determine the effectiveness of ethanol extract of guava (Psidium guajava L.) leaves on the decrease in blood sugar levels in male mice. The research method employed was maceration, phytochemical screening, and antidiabetic testing with the pre-test and post-test control group design methods to determine if there was a decrease after administration of the extract. The findings indicated that the phytochemical screening test found that guava (Psidium guajava L.) contained secondary metabolites, including alkaloids, flavonoids, and tannins. In contrast, the antidiabetic test revealed that three extracts with concentrations of 50 mg, 100 mg. and 200 mg could decrease blood sugar levels by 15%, 21%, and 47%, respectively. From these findings, it can be concluded that antidiabetic compounds which play a role in the ellanol extrict of guava (Psidium guajava L.) leaves are alkaloids, flavonoids, and tannins.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140502949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-19DOI: 10.37311/jsscr.v6i1.21889
T. S. Tuloli, Juliyanti Akuba, E. Djuwarno, A.Takdir Makkulawu, Riska Ahmad
Acute respiratory infection (ARI) is a disease with a high prevalence. Most ARIs that occur are caused by viruses and do not require antibiotics. This study aims to determine whether or not Acute Respiratory Infection (ARI) patients at Gorontalo Regency Health Center treated with antibiotic and to determine the appropriate drugs, appropriate indication, appropriate patients, and appropriate dose in Acute Respiratory Infection (ARI) patients. This study is conducted retrospectively by taking data from the medical records of 300 ARI patients. Patient characteristics by sex are: male patients are 49% and females 51%. Most patients with ARI occurred at the age of 0-5 years are 155 cases (51.7%), 6-10 years are 47 cases (15.7%), 21-25 years are 39 cases (13%), 16-20 years are 31 cases (10.3%), and 11-15 years are 28 cases (9.3%). The research findings discover that the use of antibiotic drug in ARI patients comprises Amoxicillin for 51 cases (17%), Amoxicillin syrup for 13 cases (4,3%), Amoxicillin powder for 46 cases (15,3%), Cotrimoxazole for 2 cases (0,6%), Cefadroxil for 2 cases (0,6%), and Ciprofloxacin for 1 case (0,5%). In the meantime, those who are not treated with antibiotic drug are 185 cases (61,7%). Additionally, the use of drugs includes appropriate drugs for 86,7%, appropriate indications for 62,3%, appropriate doses for 72,3%, and appropriate patients for 100% which have been in accordance with clinical practice manual book in the primary health facility.
{"title":"Profil Penggunaan Obat Antibiotik pada Penderita Infeksi Saluran Pernapasan Akut (ISPA) di Puskesmas Kabupaten Gorontalo","authors":"T. S. Tuloli, Juliyanti Akuba, E. Djuwarno, A.Takdir Makkulawu, Riska Ahmad","doi":"10.37311/jsscr.v6i1.21889","DOIUrl":"https://doi.org/10.37311/jsscr.v6i1.21889","url":null,"abstract":"Acute respiratory infection (ARI) is a disease with a high prevalence. Most ARIs that occur are caused by viruses and do not require antibiotics. This study aims to determine whether or not Acute Respiratory Infection (ARI) patients at Gorontalo Regency Health Center treated with antibiotic and to determine the appropriate drugs, appropriate indication, appropriate patients, and appropriate dose in Acute Respiratory Infection (ARI) patients. This study is conducted retrospectively by taking data from the medical records of 300 ARI patients. Patient characteristics by sex are: male patients are 49% and females 51%. Most patients with ARI occurred at the age of 0-5 years are 155 cases (51.7%), 6-10 years are 47 cases (15.7%), 21-25 years are 39 cases (13%), 16-20 years are 31 cases (10.3%), and 11-15 years are 28 cases (9.3%). The research findings discover that the use of antibiotic drug in ARI patients comprises Amoxicillin for 51 cases (17%), Amoxicillin syrup for 13 cases (4,3%), Amoxicillin powder for 46 cases (15,3%), Cotrimoxazole for 2 cases (0,6%), Cefadroxil for 2 cases (0,6%), and Ciprofloxacin for 1 case (0,5%). In the meantime, those who are not treated with antibiotic drug are 185 cases (61,7%). Additionally, the use of drugs includes appropriate drugs for 86,7%, appropriate indications for 62,3%, appropriate doses for 72,3%, and appropriate patients for 100% which have been in accordance with clinical practice manual book in the primary health facility.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"73 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140503291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Schizophrenia is one of the most common forms of psychotic mental disorder, with the main symptoms being the absence of self-understanding (insight) and the inability to assess reality (reality testing ability is disturbed). This study aimed to determine the description of the antipsychotic drug's usage, including the drug classes, types, doses, and medication rules in schizophrenia patients at the Kota Selatan Public Health Center, Gorontalo City. This observational study used secondary data and was conducted retrospectively. Further, data obtained from the medical records of 25 schizophrenia patients were analyzed univariately. The results disclosed that schizophrenia was more experienced by men (60%), more prevalent in the age range of 36-45 years (52%), and unmarried (48%)The most widely used antipsychotic drugs were atypical groups (72%). The most widely used type of drug was Risperidone 2 mg with a rule of use of 2 x 1 (39%) and 1 x 1 (9%). Clozapine, 25 mg. with a rule of 2 x 1 was 14%, and 1 x 1 was 9%. Meanwhile, the had 28% consisting typical group only of chlorpromazine 25 mg with tule of use of 1x 1 (12%), haloperidol with a dose of 1.5 mg with a rule of use of 2 sikzonoate 25 mg/ml with 1 x 1 was 5%.
精神分裂症是最常见的精神病之一，主要症状是缺乏自我理解（洞察力）和无法评估现实（现实测试能力受到干扰）。本研究旨在确定戈伦塔洛市科塔塞拉坦（Kota Selatan）公共卫生中心精神分裂症患者使用抗精神病药物的情况，包括药物类别、类型、剂量和用药规则。这项观察性研究使用了二手数据，并以回顾性方式进行。此外，还对 25 名精神分裂症患者的病历数据进行了单变量分析。结果显示，精神分裂症患者中男性居多（60%），年龄在 36-45 岁之间者居多（52%），未婚者居多（48%）。最广泛使用的药物类型是利培酮 2 毫克，使用规则为 2 x 1（39%）和 1 x 1（9%）。氯氮平 25 毫克，使用规则为 2 x 1 的占 14%，1 x 1 的占 9%。与此同时，有 28%的典型组别仅有氯丙嗪 25 毫克，使用规则为 1 x 1（12%），氟哌啶醇剂量为 1.5 毫克，使用规则为 2 x 1，25 毫克/毫升，使用规则为 1 x 1，占 5%。
{"title":"Gambaran Penggunaan Obat Antipsikotik pada Pasien Skizofrenia di Puskesmas Kota Gorontalo","authors":"Herlina Jusuf, Madania Madania, Fika Nuzul Ramadhani, Dizky Ramadani putri Papeo, Maryam Kalasi","doi":"10.37311/jsscr.v6i1.23849","DOIUrl":"https://doi.org/10.37311/jsscr.v6i1.23849","url":null,"abstract":"Schizophrenia is one of the most common forms of psychotic mental disorder, with the main symptoms being the absence of self-understanding (insight) and the inability to assess reality (reality testing ability is disturbed). This study aimed to determine the description of the antipsychotic drug's usage, including the drug classes, types, doses, and medication rules in schizophrenia patients at the Kota Selatan Public Health Center, Gorontalo City. This observational study used secondary data and was conducted retrospectively. Further, data obtained from the medical records of 25 schizophrenia patients were analyzed univariately. The results disclosed that schizophrenia was more experienced by men (60%), more prevalent in the age range of 36-45 years (52%), and unmarried (48%)The most widely used antipsychotic drugs were atypical groups (72%). The most widely used type of drug was Risperidone 2 mg with a rule of use of 2 x 1 (39%) and 1 x 1 (9%). Clozapine, 25 mg. with a rule of 2 x 1 was 14%, and 1 x 1 was 9%. Meanwhile, the had 28% consisting typical group only of chlorpromazine 25 mg with tule of use of 1x 1 (12%), haloperidol with a dose of 1.5 mg with a rule of use of 2 sikzonoate 25 mg/ml with 1 x 1 was 5%.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"389 1-3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140502777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-14DOI: 10.37311/jsscr.v5i3.24069
Khairil Pahmi, M. Sidratullah
Dysregulation of the oncoprotein c-Myc (Myc) is involved in many types of cancer. Myc is a sequence-specific transcription factor that regulates the transcription of genes involved in the control of cell proliferation and apoptosis through mechanisms that are not well understood. The method of this research is experimental. The experiment result will be described. Some processes will be done by polymerase chain reaction (PCR) to amplify the gene and then it will be extracted to pure the targeted gene. This research has been succesful to purify 3×Myc PKG-Puro-Poly A gene. c-MYC (hereinafter MYC) is an oncoprotein consisting of 439 amino acids contains a well-characterized C-terminal DNA compound and an N-terminal transactivation domain (TAD). The C-terminal region »100 residues comprises a basic leucine zipper-helix-loop-helix (bHLH-LZ) segment that regulates heterodimerization between MYC and its partner bHLH-LZ MAX mediate in their binding to gene promoters.
许多类型的癌症都与癌蛋白 c-Myc（Myc）的失调有关。Myc是一种序列特异性转录因子，通过尚不十分清楚的机制调节参与控制细胞增殖和凋亡的基因的转录。本研究的方法是实验法。将对实验结果进行描述。 一些过程将通过聚合酶链反应（PCR）来扩增基因，然后提取纯化目标基因。c-MYC （以下简称 MYC）是一种由 439 个氨基酸组成的肿瘤蛋白，含有一个特征明确的 C 端 DNA 复合物和一个 N 端转录激活域（TAD）。C 端区域 "100 个残基包括一个基本亮氨酸拉链-螺旋-环-螺旋（bHLH-LZ）区段，该区段调节 MYC 与其伙伴 bHLH-LZ MAX 之间的异源二聚体，介导它们与基因启动子的结合。
{"title":"Purification of 3×Myc PKG-Puro-Poly A Gene for Bacterial Transformation","authors":"Khairil Pahmi, M. Sidratullah","doi":"10.37311/jsscr.v5i3.24069","DOIUrl":"https://doi.org/10.37311/jsscr.v5i3.24069","url":null,"abstract":"Dysregulation of the oncoprotein c-Myc (Myc) is involved in many types of cancer. Myc is a sequence-specific transcription factor that regulates the transcription of genes involved in the control of cell proliferation and apoptosis through mechanisms that are not well understood. The method of this research is experimental. The experiment result will be described. Some processes will be done by polymerase chain reaction (PCR) to amplify the gene and then it will be extracted to pure the targeted gene. This research has been succesful to purify 3×Myc PKG-Puro-Poly A gene. c-MYC (hereinafter MYC) is an oncoprotein consisting of 439 amino acids contains a well-characterized C-terminal DNA compound and an N-terminal transactivation domain (TAD). The C-terminal region »100 residues comprises a basic leucine zipper-helix-loop-helix (bHLH-LZ) segment that regulates heterodimerization between MYC and its partner bHLH-LZ MAX mediate in their binding to gene promoters.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140509043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-06-12DOI: 10.37311/jsscr.v4i1.13630
Nur Rahma Dwi Cahya, W. Abdulkadir, Hamsidar Hasan
Purple eggplant skin (Solanum melongena L.) is one of the herbal plants that contain compounds such as flavonoids, alkaloids, saponnins, tannins, and terpenoids that are beneficial for health. This research is a laboratory experimental study that aims to determine the level of acute toxicity (LC50) of the ethanol extract of purple eggplant skin (Solanum melongena L.) using the Brine Shrimp Lethality Test (BSLT) method. Purple eggplant peel extraction was carried out using 70% ethanol as solvent. This test was conducted using 10 Artemia salina Leach larvae with 3 replications at 6 concentration variants, which are 500 ppm, 250 ppm, 125 ppm, 50 ppm, 25 ppm, and 12.5 ppm, along with negative controls. The larval mortality rate was observed after 24 hours of adding extract. The result of probit analysis showed that the LC50 value of the ethanol extract of purple eggplant skin (Solanum melongena L.) was 100.8 ppm. Moreover, the results of LC50 1000 ppm indicated that the ethanol extract of purple eggplant skin (Solanum melongena L.) was considered toxic and potential to be an anticancer agent.
{"title":"Uji Toksisitas Ekstrak Etanol Kulit Terong Ungu (Solanum melongena L.) Menggunakan Metode Brine Shrimp Lethality Test (BSLT)","authors":"Nur Rahma Dwi Cahya, W. Abdulkadir, Hamsidar Hasan","doi":"10.37311/jsscr.v4i1.13630","DOIUrl":"https://doi.org/10.37311/jsscr.v4i1.13630","url":null,"abstract":"Purple eggplant skin (Solanum melongena L.) is one of the herbal plants that contain compounds such as flavonoids, alkaloids, saponnins, tannins, and terpenoids that are beneficial for health. This research is a laboratory experimental study that aims to determine the level of acute toxicity (LC50) of the ethanol extract of purple eggplant skin (Solanum melongena L.) using the Brine Shrimp Lethality Test (BSLT) method. Purple eggplant peel extraction was carried out using 70% ethanol as solvent. This test was conducted using 10 Artemia salina Leach larvae with 3 replications at 6 concentration variants, which are 500 ppm, 250 ppm, 125 ppm, 50 ppm, 25 ppm, and 12.5 ppm, along with negative controls. The larval mortality rate was observed after 24 hours of adding extract. The result of probit analysis showed that the LC50 value of the ethanol extract of purple eggplant skin (Solanum melongena L.) was 100.8 ppm. Moreover, the results of LC50 1000 ppm indicated that the ethanol extract of purple eggplant skin (Solanum melongena L.) was considered toxic and potential to be an anticancer agent.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114682684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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