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Pengaruh Pemberian Lozenges Kombinasi Kulit Pisang dan Kulit Nanas terhadap Tikus Putih (Rattus norvegicus L.) galur Wistar 香蕉皮和菠萝皮结合对白老鼠(Rattus norvegicus L.)的影响
Pub Date : 2023-04-04 DOI: 10.37311/jsscr.v4i1.13811
Adelita Ahyanurri, Liza Pratiwi, Hadi Kurniawan, Inarah Fajriaty, Siti Nani Nurbaeti, Nugraha Fajar, Pratiwi Apridamayanti
Banana peel and pineapple peel have high potassium content. The banana peel and pineapple peel combination can be used as lozenges in potassium supportive therapy. The safety of banana peel and pineapple peel combination lozenges must be ensured by the acute toxicity test. One of the parameters observed during toxicity testing is the organ index. This study aims to determine the relationship between dose and toxicity in acute oral administration of banana peel and pineapple peel combination lozenges on the heart, lungs, liver, spleen, and kidneys organ index in white rats (Rattus norvegicus L.) Wistar strain. Acute toxicity based on OECD 425 guidelines for the Up-and-Down Procedure (UDP) method. Rats were grouped into 2000 mg/kg BW and 5000 mg/kg BW dose groups, consisting of 5 rats. Organ indexes were analyzed using SPSS Independent Sample T-test with 95% confidence level (p0.05). The result showed no significant difference between both doses (P0.05) in heart, lungs, liver, spleen, and kidneys organ index. Based on the results, it can be concluded that banana peel and pineapple peel combination lozenges did not affect white rats’ heart, lungs, liver, spleen, and kidney organ index.
香蕉皮和菠萝皮的钾含量很高。香蕉皮和菠萝皮的组合可以作为含片用于钾支持治疗。香蕉皮菠萝皮复合含片的安全性必须通过急性毒性试验来保证。在毒性试验中观察到的参数之一是器官指数。本研究旨在探讨香蕉皮菠萝皮联合含片急性口服对褐家鼠(Rattus norvegicus L.)心、肺、肝、脾、肾脏器指数的影响及其剂量与毒性的关系。纯种的压力。急性毒性基于OECD 425上下程序(UDP)方法指南。将大鼠分为2000 mg/kg BW和5000 mg/kg BW剂量组,每组5只。脏器指数分析采用SPSS独立样本t检验,95%置信水平(p0.05)。结果显示,两组大鼠心、肺、肝、脾、肾脏器指数差异无统计学意义(P0.05)。由此可见,香蕉皮、菠萝皮联合含片对大鼠心、肺、肝、脾、肾等脏器指数无明显影响。
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引用次数: 0
Penggolongan Obat Berdasarkan Peresepan Obat Asma Di Instalasi Rawat Jalan RSUD Dr Agoesdjam Ketapang 由哮喘药物引起的药物标签
Pub Date : 2023-04-04 DOI: 10.37311/jsscr.v4i1.13648
Defiga Kasrin, Liza Pratiwi, Shoma Rizkifani
Asthma was included in the top ten causes of morbidity and mortality in Indonesia. The priority of asthma treatment so far is to control symptoms. Therefore, the classification of drugs based on asthma drug prescribing is very necessary. This study aims to determine the characteristics and classes of drug prescribing in outpatient asthma patients at RSUD Dr. Agoesdjam Ketapang in 2020. This research method was carried out in December 2021-January 2022 with a retrospective descriptive method, data obtained from medical record cards of outpatient asthma patients at RSUD Dr. Agoesdjam Ketapang in 2020. The data obtained are presented in the form of percentages, average values and tables. The results showed that of the 61 outpatient asthma patient medical records analyzed by the percentage data, the majority of patients were women (59%) and at the age of 42-49 years (31%). The most widely prescribed drug group was beta-2 agonist (48%) with the most common dosage form being inhalers (51%) and the route of drug use was inhalation (51%). The conclusion is that the use of drugs in asthma patients in the outpatient installation of RSUD Dr. The majority of Agoesdjam Ketapang are women. The majority occurred at the age of 42-49 years, the most widely used drug class was the beta-2 agonist group with the inhaler dosage form and the inhalation route was the most widely used.
在印度尼西亚,哮喘被列为十大发病和死亡原因之一。到目前为止,哮喘治疗的重点是控制症状。因此,基于哮喘药物处方进行药物分类是非常有必要的。本研究旨在确定2020年RSUD Dr. Agoesdjam Ketapang门诊哮喘患者的特征和药物处方类别。本研究方法于2021年12月至2022年1月进行,采用回顾性描述性方法,数据来自RSUD Agoesdjam Ketapang博士2020年门诊哮喘患者的病历卡。所得数据以百分比、平均值和表格的形式呈现。结果显示,采用百分比数据分析的61例门诊哮喘患者病历中,以女性(59%)居多,年龄在42 ~ 49岁(31%)。使用最广泛的药物组为β -2激动剂(48%),最常见的剂型为吸入剂(51%),用药途径为吸入剂(51%)。结论是,使用药物的哮喘患者在门诊安装RSUD医生,绝大多数是女性。主要发生在42-49岁,使用最广泛的药物类别为吸入剂剂型的β -2激动剂组,吸入途径使用最广泛。
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引用次数: 0
Pengaruh Pemberian Kombinasi Ekstrak Kulit Pisang dan Kulit Nanas terhadap Indeks Organ Tikus Wistar 香蕉皮和菠萝皮提取物对树鼠器官索引的影响
Pub Date : 2023-04-04 DOI: 10.37311/jsscr.v4i1.13910
Melania Niken Safira, Pratiwi Apridamayanti, Hadi Kurniawan, Inarah Fajriaty, Fajar Nugraha, Siti Nani Nurbaeti, Liza Pratiwi
Banana peel and pineapple peel contain potassium which may be developed into health supplements. The development of banana peels and pineapple peels as ingredients for potassium supplements must meet safety aspects that can be proven by subchronic toxicity tests. This subchronic toxicity test aimed to determine the effect of repeated administration of a combination of banana peel and pineapple peel extract for 28 days on the liver, kidney, kidney, lung, heart, and spleen index of Wistar rats. This research used male and female white rats which were divided into six treatment groups, namely the control group, low dose, middle dose, high dose, satellite control, and high dose satellite. The results showed that there was a significant increase in the liver and kidney organ index, and a significant decrease in the adrenal gland organ index after administration of a combination of banana peel and pineapple peel extract. This research concludes that the combination of banana peel and pineapple peel extract has an effect on the liver, kidney, and adrenal gland organ index in Wistar white rats.
香蕉皮和菠萝皮中含有钾,可开发成保健品。开发香蕉皮和菠萝皮作为钾补充剂的成分必须符合安全方面,可以通过亚慢性毒性试验证明。本亚慢性毒性试验旨在确定香蕉皮和菠萝皮提取物组合重复给药28天对Wistar大鼠肝、肾、肾、肺、心和脾指数的影响。本研究选用雄性和雌性大鼠,将其分为对照组、低剂量组、中剂量组、高剂量组、卫星对照组和高剂量卫星组。结果表明,香蕉皮和菠萝皮提取物联合施用后,大鼠肝脏和肾脏器官指数显著升高,肾上腺器官指数显著降低。本研究认为,香蕉皮和菠萝皮提取物联合使用对Wistar大鼠的肝、肾和肾上腺器官指数有影响。
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引用次数: 0
Efek Antelmintik Ekstrak Metanol Kulit Batang Nangka (Artocarpus heterophyllus) terhadap Cacing Ascaris lumbricoides 抗甲菌皮对斑藻虫的影响
Pub Date : 2023-03-31 DOI: 10.37311/jsscr.v4i1.14217
Hamsidar Hasan, Nur Ain Thomas, M. Taupik, Gita Potabuga
Jackfruit (Artocarpus heterophyllus) is a type of plant that grows in Indonesia which functions as a food ingredient and as traditional medicine. Generally, this genus contains prenylated flavonoid compounds. This study aimed to determine the anthelmintic effect of jackfruit bark extract against Ascaris lumbricoides worms by utilizing total maceration with methanol solvent as the extraction method, which yielded 6.61%. Roundworm Ascaris lumbricoides are found in pig intestines. The samples were divided into 5 groups, including positive control of 250 mg combantrin solution, negative control of NaCMC and a treatment group of jackfruit bark extract with a concentration of 1%, 3%, and 5%. Each group consisted of three worms, incubated at 37oC for 24 hours with a 6 hours interval. The results showed that at a concentration of 5%, a jackfruit bark extract was efficient as an anthelmintic caused two worms to lyse at 6 hours and  one at 12 hours.
菠萝蜜(Artocarpus heterophyllus)是一种生长在印度尼西亚的植物,具有食品成分和传统药物的功能。通常,该属含有烯酰化的类黄酮化合物。本研究采用甲醇溶剂全浸渍法提取菠萝蜜皮提取物,测定其对蛔虫的驱虫效果,提取率为6.61%。蛔虫是在猪的肠子里发现的。将样品分为5组,阳性对照组为250 mg复方蒿甲素溶液,阴性对照组为NaCMC,处理组为浓度为1%、3%、5%的菠萝蜜皮提取物。每组3只,37℃孵育24小时,间隔6小时。结果表明,在浓度为5%的条件下,菠萝蜜树皮提取物可以有效地驱虫药,在6小时和12小时分别有2只和1只线虫腐烂。
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引用次数: 2
Tingkat Pengetahuan Pasien Penderita Tuberculosis Dalam Program Pengobatan Tuberculosis di Puskesmas 结核病结核病治疗项目患者的知识水平
Pub Date : 2023-03-31 DOI: 10.37311/jsscr.v4i1.14220
Madania Madania, Mahdalena Sy. Pakaya, Teti Sutriati Tuloli, W. Abdulkadir
Tuberculosis is an infectious disease caused by bacteria known as mycobacterium tuberculosis. In Indonesia, tuberculosis is the third common public health problem the prevalence of the disease in this country is among the highest in the world after China and India. Sufficient knowledge of diseases and medicines correlates with the result of therapy in general. Knowledge about drugs is important for patients since it helps them to consume drugs properly (which result in maximum therapy) and to avoid complications. The purpose of this descriptive study is to determine the level of knowledge of patients suffering from tuberculosis in the tuberculosis treatment program at Bulango Utara Puskesmas (Community Health Center) by a questionnaire. It applied a cross-sectional approach with primary data obtained from the result of a sample questionnaire totaling 24 patients taken by saturated sampling. The result of this present study reveal that the level knowledge of patients with tuberculosis in the area is still relatively low at 75%, while only 25% is classified as moderate.
结核病是一种由结核分枝杆菌引起的传染病。在印度尼西亚,结核病是第三大常见的公共卫生问题,该国的患病率仅次于中国和印度,是世界上最高的。充分的疾病和药物知识通常与治疗结果相关。药物知识对患者很重要,因为它有助于他们正确用药(从而获得最大的治疗效果)并避免并发症。这项描述性研究的目的是通过问卷调查确定Bulango Utara Puskesmas(社区卫生中心)结核病治疗方案中结核病患者的知识水平。它采用横断面方法,主要数据来自饱和抽样共24例患者的抽样问卷结果。本研究结果显示,该地区结核病患者的水平知识水平仍然相对较低,为75%,而只有25%被归类为中度。
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引用次数: 0
Evaluasi Kesesuaian Peresepan Obat Pada Pasien Poliklinik Penyakit Dalam Terhadap Formularium di Rumah Sakit 对医院内病理多发性硬化症患者的药物镇静剂进行评估
Pub Date : 2023-03-31 DOI: 10.37311/jsscr.v4i1.14219
Teti Sutriati Tuloli, Madania Madania, Nur Rasdianah, Indah Pramesty Gobel
National formulary is a list of medicines compiled by a national committee established by the Minister of Health based on cutting-edge, efficacious, safe, and affordable scientific evidence referred for drug use by national health insurance. This study aims to determine the evaluation of drug prescribing in the Hospital formulary. This retrospective study involved subjects qualified for the inclusion criteria i.e. 73 sheet recipes in August - December 2019. some prescribed drugs that are not listed in the hospital formulary in the following percentage: August (100%), September (60%), October (50%), November (81%), and December (65%) with the average of 71%. This indicates that the prescription does not conform to the hospital formulary regulation of 100%. In conclusion, there are some drugs prescribed by the doctor that is not conformed to the hospital formulary, which means tight supervision for the prescribing is required.
国家处方集是由卫生部设立的一个国家委员会根据国家健康保险提供的尖端、有效、安全和负担得起的科学证据编制的一份药物清单。本研究旨在确定医院处方中药物处方的评价。本回顾性研究纳入了符合纳入标准的受试者,即2019年8月至12月期间的73份薄片食谱。未列入医院处方册的药品比例依次为:8月(100%)、9月(60%)、10月(50%)、11月(81%)、12月(65%),平均为71%。说明该处方100%不符合医院处方规定。总之,医生开的一些药不符合医院的处方,这意味着需要对处方进行严格的监管。
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引用次数: 1
Gambaran Praktik Five Moment Cuci Tangan Pada Perawat Di Puskesmas 五分钟的实践场景洗手在医院的护士
Pub Date : 2022-07-18 DOI: 10.37311/jsscr.v2i2.15453
Hilmawaty Susanthy Kue Paudi
The prevalence of nosocomial infections around the world is a serious concern for all health services, especially in hospitals. One of the contributing factors is non-compliance in the implementation of handwashing procedures in accordance with standard operating procedures. The study aims to determine the level of compliance of nurses in the implementation of the five-moment Handwashing at the Dungingi Health Center in 2020. The design used is obsevasional descriptive with a cross sectional approach. The total sample was 97 people taken by purposive sampling . The data analysis carried out in this study is univariate data analysts. The results of the study found that most respondents had a compliance rate of less than 69.1%, moderate compliance as much as 18.6% and good compliance as much as 12.4%. It is recommended that all nurses be more concerned about the importance of implementing the five-moment hand hygiene standard procedure, and the Puskesmas provides rewards to nurses who are obedient in implementing these standards.
世界各地医院感染的流行是所有卫生服务部门,特别是医院的一个严重关切问题。其中一个原因是没有按照标准作业程序执行洗手程序。本研究旨在确定2020年邓吉吉健康中心护士实施五分钟洗手的依从性水平。所使用的设计是用横断面方法观察描述性的。有目的抽样共97人。本研究采用单变量数据分析方法进行数据分析。研究结果发现,大多数受访者的合规率低于69.1%,中等合规率高达18.6%,良好合规率高达12.4%。建议所有护士更加关注实施五分钟手部卫生标准程序的重要性,Puskesmas对遵守这些标准的护士提供奖励。
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引用次数: 0
Tingkat Pengetahuan Mahasiswa Fakultas Kedokteran Universitas Tanjungpura Tentang Obat Antihipertensi Pada Masa Pandemi COVID-19 坦永普拉大学医学院学生对COVID-19大流行抗高血压药物的了解水平
Pub Date : 2022-04-29 DOI: 10.37311/jsscr.v4i2.14170
Rosita Dewi, Ressi Susanti, Nurmainah Nurmainah
During the COVID-19 pandemic, hypertension became a comorbid with the highest number of deaths. As a health student, it is important to have knowledge related to hypertension and antihypertensive drugs as a basis for providing education to the public. The purpose of this study is to evaluate college students level of knowledge regarding antihypertensive drugs during the COVID-19 pandemic. This study used a descriptive observational research with a cross sectional at the Faculty of Medicine, Tanjungpura University. Samples were gathered by purposive sampling with a total of 338 respondents who are active students of the S-1 study program class 2018, 2019, 2020, and 2021. The research instrument is a questionnaire in the form of a google form, with a Guttman scale and analyzed using univariate to describe variables study. The results showed that the level of knowledge of students in the good category was 56.71% with 186 respondents. The level of knowledge in the good category according to the age factor was 58.72% with 101 students in the age range of 19-20 years. According to the gender factor, the level of knowledge of students in the good category was 56.76% with 147 students with the majority being women. The conclusion from the research is that most of the knowledge levels of students at the Faculty of Medicine, Tanjungpura University, show a good level of knowledge about hypertension and hypertension drugs.
在2019冠状病毒病大流行期间,高血压成为死亡人数最多的合并症。作为一名健康专业的学生,掌握与高血压和降压药相关的知识,作为对公众进行教育的基础是非常重要的。本研究的目的是评估新冠肺炎大流行期间大学生抗高血压药物知识水平。本研究采用丹戎普拉大学医学院的横断面描述性观察研究。通过有目的抽样收集样本,共有338名受访者是S-1学习计划2018、2019、2020和2021班的活跃学生。研究工具为google表格形式的问卷,采用Guttman量表进行分析,采用单变量描述变量研究。结果显示,186名受访学生中,“好”类学生的知识水平为56.71%。按年龄因子划分,有101名学生在19 ~ 20岁之间,知识水平为良好的占58.72%。根据性别因素,好类学生的知识水平为56.76%,有147名学生,其中以女性为主。研究得出的结论是,丹戎普拉大学医学院学生的大部分知识水平,对高血压和高血压药物的知识水平都很好。
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引用次数: 0
Tingkat Pengetahuan Mahasiswi Fakultas Kedokteran Universitas Tanjungpura Tentang Manfaat Jahe Merah Terhadap Penurunan Dismenore 坦永普拉大学医科学生的知识水平,说明红姜对痛经下降的好处
Pub Date : 2022-04-28 DOI: 10.37311/jsscr.v4i2.14169
Hapizah Saputri, Ressi Susanti, Nurmainah Nurmainah
The use of conventional drugs in overcoming dysmenorrhea (painful menstruation) is known to cause side effects. Alternative medicine that can be done to overcome dysmenorrhea by using red ginger. The purpose of this study was to describe the level of knowledge of age in students of the Faculty of Medicine, Tanjungpura University, Department of Medicine, Pharmacy, and Nursing about the benefits of red ginger in reducing dysmenorrhea. This research is a descriptive observational study using a cross sectional research design. The technique used in sampling is purposive sampling technique. The research instrument was an online questionnaire in the form of a google form. Univariate analysis was used to describe the distribution of respondents from each variable. The results showed that respondents with a good level of knowledge aged 17-18 years were 57 (82.61%) respondents, respondents aged 19-20 years were 131 (81.88%), and respondents aged 21-22 years were found. as many as 68 (88.31%). The conclusion of this study is that the level of knowledge of female students about the benefits of using red ginger in overcoming dysmenorrhea is quite good (83.66%).
众所周知,使用传统药物治疗痛经(痛经)会产生副作用。用红姜治疗痛经的替代疗法。本研究旨在了解丹戎普拉大学医学部药学与护理系学生对红姜治疗痛经的认知程度。本研究是采用横断面研究设计的描述性观察性研究。抽样采用的是目的性抽样技术。研究工具是一份谷歌表格形式的在线问卷。单变量分析用于描述每个变量的受访者分布。结果表明,17-18岁的受访者中有57人(82.61%),19-20岁的受访者中有131人(81.88%),21-22岁的受访者中有21-22岁的受访者。多达68例(88.31%)。本研究的结论是,女大学生对使用红姜治疗痛经的益处的了解程度较好(83.66%)。
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引用次数: 0
Formulasi dan Evaluasi Kestabilan Fisik Krim Ekstrak Biji Lada Hitam (Piper nigrum L.) Menggunakan Variasi Emulgator 配方和物理稳定性评价黑胡椒籽培养霜(Piper nigrum L)。采用肌油变体
Pub Date : 2022-04-27 DOI: 10.37311/jsscr.v4i2.14146
Andi Nur Zam Zam, Musdalifah Musdalifah
Black papper seed extract has known for its antivitiligo potential. The  addition  of  black papper seed  extract was predicted can influence the physical  stability  of  the  cream.  Therefore, this research was aimed to test the physical stability of cream contained  black papper seed extract in varity of emulgator there is tween® 60-span® 60, tween® 80-span® 80, novemer®, dan viscolam®. Physical stability test using the cycling test method by storing the preparation at 4 ° ± 2 ° C for 24 hours and then storing it at 40°±2°C) for 24 hours. The storage time at these two different temperatures is considered as one cycle and carried out for 12 days. The stability parameters were organoleptic observations, homogeneity, dispersion, pH, viscosity and cycling test results. The results showed that there were differences in organoleptic values, pH, viscosity, homogeneity and dispersibility. The most stable cream was obtained, namely the cream formula using emulgator Tween® 60-span® 60, had a good organoleptic value, cream type m/a, pH 5.10, viscosity 46,800 cPs, spreadability 4.2 cm2, homogeneous cream . The results of this study indicate that black pepper seed extract cream can be formulated into a stable cream preparation.
黑纸籽提取物以其抗白癜风的潜力而闻名。预测了黑纸籽提取物的加入对乳膏的物理稳定性有影响。因此,本研究旨在测试黑纸籽提取物乳膏在不同乳化剂(tween®60-span®60、tween®80-span®80、novemer®、dan viscolam®)中的物理稳定性。物理稳定性试验采用循环试验法,先在4°±2°C下保存24小时,再在40°±2°C下保存24小时。在这两种不同温度下的储存时间被认为是一个周期,进行了12天。稳定性参数为感官观察、均匀性、分散性、pH、粘度和循环试验结果。结果表明,在感官值、pH值、粘度、均匀性和分散性方面存在差异。使用乳化剂Tween®60-span®60制备的乳膏配方具有良好的感官值,乳膏类型m/a, pH 5.10,粘度46,800 cPs,涂抹性4.2 cm2,乳膏均匀。研究结果表明,黑胡椒籽提取物乳膏可以配制成稳定的乳膏制剂。
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引用次数: 0
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Journal Syifa Sciences and Clinical Research
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