Pub Date : 2021-08-30DOI: 10.37311/JSSCR.V3I2.11398
Hadi Kurniawan, Meri Ropiqa
Daun Ekor Kucing (Acalypha hispida Burm.f.) merupakan jenis tanaman hias yang telah dikenal masyarakat Indonesia untuk pengobatan, namun belum ada penelitian untuk meneliti toksisitas akut daun ekor kucing. Tanaman ini mengandung senyawa alkaloid dan flavonoid. Tujuan dari penelitian ini adalah untuk mengetahui potensi ketoksikan akut ekstrak etanol daun ekor kucing (A. hispida Burm.f.) terhadap larva Artemia salina Leach dengan metode Brine Shrimp Lethality Test (BSLT) yang ditunjukkan dengan nilai LC50. Penelitian eksperimental ini menggunakan 300 ekor larva udang (Artemia salina Leach) yang dibagi menjadi 5 kelompok kontrol negatif dan 5 kelompok seri konsentrasi ekstrak. Masing-masing kelompok terdiri dari 10 ekor larva dengan replikasi 3 kali untuk tiap kelompok perlakuan. Kelima kelompok perlakuan diberi suspensi sediaan uji ekstrak etanol daun ekor kucing dengan konsentrasi 100 ppm, 250 ppm, 500 ppm, 750 ppm, dan 1.000 ppm. Data kematian Artemia salina Leach dianalisis dengan analisis probit untuk mengetahui nilai LC50. Hasil penelitian ini menunjukkan harga LC50 dari ekstrak etanol daun ekor kucing adalah 220,005 ppm. Ekstrak etanol daun ekor kucing memiliki potensi toksisitas akut terhadap larva Artemia salina Leach menurut metode BSLT yang ditunjukkan dengan harga LC50 1.000 ppm.
{"title":"Uji Toksisitas Ekstrak Etanol Daun Ekor Kucing (Acalypha hispida Burm.f.) Dengan Metode Brine Shrimp Lethality Test (BSLT)","authors":"Hadi Kurniawan, Meri Ropiqa","doi":"10.37311/JSSCR.V3I2.11398","DOIUrl":"https://doi.org/10.37311/JSSCR.V3I2.11398","url":null,"abstract":"Daun Ekor Kucing (Acalypha hispida Burm.f.) merupakan jenis tanaman hias yang telah dikenal masyarakat Indonesia untuk pengobatan, namun belum ada penelitian untuk meneliti toksisitas akut daun ekor kucing. Tanaman ini mengandung senyawa alkaloid dan flavonoid. Tujuan dari penelitian ini adalah untuk mengetahui potensi ketoksikan akut ekstrak etanol daun ekor kucing (A. hispida Burm.f.) terhadap larva Artemia salina Leach dengan metode Brine Shrimp Lethality Test (BSLT) yang ditunjukkan dengan nilai LC50. Penelitian eksperimental ini menggunakan 300 ekor larva udang (Artemia salina Leach) yang dibagi menjadi 5 kelompok kontrol negatif dan 5 kelompok seri konsentrasi ekstrak. Masing-masing kelompok terdiri dari 10 ekor larva dengan replikasi 3 kali untuk tiap kelompok perlakuan. Kelima kelompok perlakuan diberi suspensi sediaan uji ekstrak etanol daun ekor kucing dengan konsentrasi 100 ppm, 250 ppm, 500 ppm, 750 ppm, dan 1.000 ppm. Data kematian Artemia salina Leach dianalisis dengan analisis probit untuk mengetahui nilai LC50. Hasil penelitian ini menunjukkan harga LC50 dari ekstrak etanol daun ekor kucing adalah 220,005 ppm. Ekstrak etanol daun ekor kucing memiliki potensi toksisitas akut terhadap larva Artemia salina Leach menurut metode BSLT yang ditunjukkan dengan harga LC50 1.000 ppm.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122463962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-25DOI: 10.37311/JSSCR.V3I2.11376
Novia Agustina, Nurul Istiqomah
Acalypha indica L. is a species of wild plant that has secondary metabolites are used as medicine, but the usage is not optimized yet. The objective of of this study was to determine secondary metabolites content, location and distribution of secondary metabolites, and also the capacity for antioxidant. Secondary metabolites content was determined included phenol, flavonoids, tannin of chloroform and methanol extracts from Acalypha indica L. root, using spectrophotometre. Histochemical test was done by making fresh sliced preparation which was reacted with reagent. Antioxidant activity was determined by using DPPH method. The result of this study showed that secondary metabolites content of chloroform extract, were phenol 9,89 ± 0,77 %GAE, flavonoids 5,87 ± 1,40 %QE, and tannin 3,33 ± 1,21 %GAE, while methanol extract were phenol 45,11 ± 4,86 %GAE, flavonoids 19,87 ± 0,61 %QE, and tannin 6,76 ± 0,31 %GAE. Histochemical test showed that phenol, flavonoids, tannin, and alkaloids were found in Acalypha indica L. root. Antioxidant activity showed the IC50 value was 161,81 ± 7,88 μg/mL for chloroform extract and 92,81 ± 4,33 μg/mL for methanol extract.
{"title":"Analisis Kadar Metabolit Sekunder, Histokimia, dan Aktivitas Antioksidan Akar Acalypha indica L.","authors":"Novia Agustina, Nurul Istiqomah","doi":"10.37311/JSSCR.V3I2.11376","DOIUrl":"https://doi.org/10.37311/JSSCR.V3I2.11376","url":null,"abstract":"Acalypha indica L. is a species of wild plant that has secondary metabolites are used as medicine, but the usage is not optimized yet. The objective of of this study was to determine secondary metabolites content, location and distribution of secondary metabolites, and also the capacity for antioxidant. Secondary metabolites content was determined included phenol, flavonoids, tannin of chloroform and methanol extracts from Acalypha indica L. root, using spectrophotometre. Histochemical test was done by making fresh sliced preparation which was reacted with reagent. Antioxidant activity was determined by using DPPH method. The result of this study showed that secondary metabolites content of chloroform extract, were phenol 9,89 ± 0,77 %GAE, flavonoids 5,87 ± 1,40 %QE, and tannin 3,33 ± 1,21 %GAE, while methanol extract were phenol 45,11 ± 4,86 %GAE, flavonoids 19,87 ± 0,61 %QE, and tannin 6,76 ± 0,31 %GAE. Histochemical test showed that phenol, flavonoids, tannin, and alkaloids were found in Acalypha indica L. root. Antioxidant activity showed the IC50 value was 161,81 ± 7,88 μg/mL for chloroform extract and 92,81 ± 4,33 μg/mL for methanol extract.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123717606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-08-03DOI: 10.37311/jsscr.v3i2.11688
Feny Oktaviana, Puput Noviana
Typhoid fever has the highest incidence in children. Treatment for typhoid fever uses antibiotics. Increasing bacterial resistance to antibiotics is a global problem. This study was conducted to determine the differences in the effectiveness of antibiotics in the treatment of typhoid fever on the heat-free time and the length of treatment for pediatric patients in the inpatient ward of the X Hospital, Kediri City. This research is a descriptive analysis research. A retrospective study was conducted using medical records in 2017. Data were collected by purposive sampling. Data were taken on pediatric patients with typhoid fever aged 5-11 years. The statistical test used to analyze the effectiveness of therapy in pediatric patients with typhoid fever was performed using the Kruskal-Wallis test. The sample used in this study were 38 pediatric patients. The antibiotics used were ciprofloxacin 52.63%, ceftriaxone 28.95%, cefuroxim 10.53%, and penicillin 7.89%. The results of the analysis of differences in the effectiveness of antibiotics against heat-free time obtained a sig value 0.05 (0.947) and a sig value 0.05 (0.329) for the length of treatment. There was no significant difference in heat-free time and length of treatment between ceftriaxone, cefuroxim, ciprofloxacin and penicillin.
{"title":"Efektivitas Terapi Antibiotika Demam Tifoid Pada Pediatrik Di Rumah Sakit X Kota Kediri","authors":"Feny Oktaviana, Puput Noviana","doi":"10.37311/jsscr.v3i2.11688","DOIUrl":"https://doi.org/10.37311/jsscr.v3i2.11688","url":null,"abstract":"Typhoid fever has the highest incidence in children. Treatment for typhoid fever uses antibiotics. Increasing bacterial resistance to antibiotics is a global problem. This study was conducted to determine the differences in the effectiveness of antibiotics in the treatment of typhoid fever on the heat-free time and the length of treatment for pediatric patients in the inpatient ward of the X Hospital, Kediri City. This research is a descriptive analysis research. A retrospective study was conducted using medical records in 2017. Data were collected by purposive sampling. Data were taken on pediatric patients with typhoid fever aged 5-11 years. The statistical test used to analyze the effectiveness of therapy in pediatric patients with typhoid fever was performed using the Kruskal-Wallis test. The sample used in this study were 38 pediatric patients. The antibiotics used were ciprofloxacin 52.63%, ceftriaxone 28.95%, cefuroxim 10.53%, and penicillin 7.89%. The results of the analysis of differences in the effectiveness of antibiotics against heat-free time obtained a sig value 0.05 (0.947) and a sig value 0.05 (0.329) for the length of treatment. There was no significant difference in heat-free time and length of treatment between ceftriaxone, cefuroxim, ciprofloxacin and penicillin.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125207319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-13DOI: 10.37311/JSSCR.V2I1.2704
N. Nuralifah, W. Wahyuni, P. Parawansah, Ulan Dwi Shintia
Hyperlipidemia is an increase of lipid due to excessive fat consumption, that the intake and alteration of lipid is not balanced. Notika are plants that contain secondary metabolites in the form of flavonoids, tannins, saponins and triterpenoids which are antioxidant compounds that are thought to have the effect of reducing blood lipids. This study aims to determine the effect of ethanol extract of leaves of Notika on decreasing total cholesterol levels in rats induced by egg and propylthiouracil (PTU). This research was experimental in 6 groups, namely 4 groups given ethanol extract of leaves of Notika at a dose of 50 mg/kgBB, 100 mg/kgBB, 200 mg/kgBB, and 300 mg/kgBB, one group was given Na CMC 0.5% as a negative control, and one group was given simvastatin 10 mg as a positive control. The results showed that the ethanol extract of the leaves of Notika significantly reduced the total cholesterol level of rats with a significant value 0.05 and 300 mg/kgBB is an effective dose to reduce total cholesterol level.
{"title":"Uji Aktivitas Antihiperlipidemia Ekstrak Etanol Daun Notika (Arcboldiodendron calosericeum Kobuski) Terhadap Kadar Kolesterol Total Tikus (Rattus norvegicus) Jantan Galur Wistar","authors":"N. Nuralifah, W. Wahyuni, P. Parawansah, Ulan Dwi Shintia","doi":"10.37311/JSSCR.V2I1.2704","DOIUrl":"https://doi.org/10.37311/JSSCR.V2I1.2704","url":null,"abstract":"Hyperlipidemia is an increase of lipid due to excessive fat consumption, that the intake and alteration of lipid is not balanced. Notika are plants that contain secondary metabolites in the form of flavonoids, tannins, saponins and triterpenoids which are antioxidant compounds that are thought to have the effect of reducing blood lipids. This study aims to determine the effect of ethanol extract of leaves of Notika on decreasing total cholesterol levels in rats induced by egg and propylthiouracil (PTU). This research was experimental in 6 groups, namely 4 groups given ethanol extract of leaves of Notika at a dose of 50 mg/kgBB, 100 mg/kgBB, 200 mg/kgBB, and 300 mg/kgBB, one group was given Na CMC 0.5% as a negative control, and one group was given simvastatin 10 mg as a positive control. The results showed that the ethanol extract of the leaves of Notika significantly reduced the total cholesterol level of rats with a significant value 0.05 and 300 mg/kgBB is an effective dose to reduce total cholesterol level.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121875983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-19DOI: 10.37311/JSSCR.V1I2.2663
Z. Ahmad, Siti Surya Indah Nurdin
Hypertension is one of the public health problems that cause mortality and inability to reach life expectancy. The aim of the research is to assess the effect of juice cucumber (Cucumis sativus Linn) on blood pressure of hypertension patients. The research used a quasi experiment design with Non-Randomized Control Group Pre-test Post-test Design. The populations include pre-hypertension and hypertension grade I patients of women childbearing age in the working area of Telaga Biru Health Centre of Gorontalo Regency. The samples were 42 pre-hypertension and hypertension grade I patients. They were divided into two groups, a group given cucumber juice without seeds and another group given cucumber juice with seeds. The data were analyzed using Paired-samples t Test and Independent-samples t Test. The result of the study indicate that giving cucumber juice without seeds decrease of systolic blood pressure by 18,524 mmHg (p = 0,000) and decrease diastolic blood pressure by 8,905 mmHg (p = 0,000). Giving cucumber juice with seeds could decrease systolic blood pressure by 15,952 mmHg (p = 0,000) and diastolic blood pressure by 7,571 mmHg (p = 0,000). There was no difference between giving cucumber juice without seeds and giving cucumber juice with seeds in the decrease of systolic blood pressure (p = 0,257) and the decrease of diastolic blood pressure (p = 0,414). This shows that giving cucumber juice can decrease blood pressure.
{"title":"Pemberian Jus Mentimun (Cucumis Sativus Linn) Pada Penderita Hipertensi Wanita Usia Produktif","authors":"Z. Ahmad, Siti Surya Indah Nurdin","doi":"10.37311/JSSCR.V1I2.2663","DOIUrl":"https://doi.org/10.37311/JSSCR.V1I2.2663","url":null,"abstract":"Hypertension is one of the public health problems that cause mortality and inability to reach life expectancy. The aim of the research is to assess the effect of juice cucumber (Cucumis sativus Linn) on blood pressure of hypertension patients. The research used a quasi experiment design with Non-Randomized Control Group Pre-test Post-test Design. The populations include pre-hypertension and hypertension grade I patients of women childbearing age in the working area of Telaga Biru Health Centre of Gorontalo Regency. The samples were 42 pre-hypertension and hypertension grade I patients. They were divided into two groups, a group given cucumber juice without seeds and another group given cucumber juice with seeds. The data were analyzed using Paired-samples t Test and Independent-samples t Test. The result of the study indicate that giving cucumber juice without seeds decrease of systolic blood pressure by 18,524 mmHg (p = 0,000) and decrease diastolic blood pressure by 8,905 mmHg (p = 0,000). Giving cucumber juice with seeds could decrease systolic blood pressure by 15,952 mmHg (p = 0,000) and diastolic blood pressure by 7,571 mmHg (p = 0,000). There was no difference between giving cucumber juice without seeds and giving cucumber juice with seeds in the decrease of systolic blood pressure (p = 0,257) and the decrease of diastolic blood pressure (p = 0,414). This shows that giving cucumber juice can decrease blood pressure.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"125 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116717149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pain is an uncomfortable feeling caused by strong or destructive stimulation, if unchecked can affect daily routine. This study aims to determine the analgesic effect and dosage of the leaf extract ethanol, as well as to determine the effectiveness of the leaf extract ethanol as a narcotic analgesic by the Tail Flick method or as a non-narcotic analgesic by the Paw Pressure Test Randall Selitto method. Extraction was done by maceration of leaf powder with a solvent 96% ethanol. 25 male Wistar white rats were divided into 5 groups, positive group mefenamic acid 9 mg /200 g BW for the Paw Pressure Test Randall Selitto Method and tramadol 0.9 mg /200 g BW for the Tail Flick Method, negative control CMC Na 0,5%, ethanol extract leaves inggu leaves a dose of 10 mg /200 g BW, 20 mg /200 g BW and 40 mg /200 g BW. The data obtained were analyzed by ANOVA test, then LSD test was used to determine differences between groups. The results showed extract dosage of 10 mg /200 g BW, 20 mg /200 g BW, 40 mg /200 g BW had analgesic effect. Extract dosage of 20 mg /200 g BW and 40 mg /200 g BW in the Randall selitto Paw Pressure Test method is equivalent to mefenamic acid, extract dose 10 mg /200 g BW, 20 mg /200 g BW, and 40 mg /200 g BW the Tail Flick method is equivalent to Tramadol. Ethanol leaf extract is more effective as a narcotic analgesic by the Tail Flick method.
疼痛是由强烈的或破坏性的刺激引起的一种不舒服的感觉，如果不加以控制，可能会影响日常生活。本研究旨在确定叶提取物乙醇的镇痛作用和用量，并通过甩尾法确定叶提取物乙醇作为麻醉性镇痛药或通过爪压试验Randall Selitto法确定叶提取物乙醇作为非麻醉性镇痛药的有效性。用96%乙醇浸渍叶粉进行提取。雄性Wistar大鼠25只，分为5组，阳性组甲胺酸9 mg /200 g BW用于爪压试验Randall Selitto法，曲马多0.9 mg /200 g BW用于甩尾法，阴性组CMC Na 0.5%，乙醇提取叶给药剂量分别为10 mg /200 g BW、20 mg /200 g BW和40 mg /200 g BW。所得资料采用方差分析(ANOVA)进行分析，再采用LSD检验确定组间差异。结果表明，10 mg /200 g BW、20 mg /200 g BW、40 mg /200 g BW提取物均有镇痛作用。Randall selitto爪压试验法中提取剂量20 mg /200 g BW和40 mg /200 g BW相当于甲氨甲胺酸，甩尾法中提取剂量10 mg /200 g BW、20 mg /200 g BW和40 mg /200 g BW相当于曲马多。用甩尾法提取乙醇叶提取物作为麻醉镇痛药效果更好。
{"title":"Uji Aktivitas Analgetik Ekstrak Etanol Daun Inggu (Ruta angustifolia [l.] Pers) Pada Tikus Putih Jantan","authors":"Yane Dila Keswara, S. Handayani","doi":"10.3731/JSSCR.V1I2.2662","DOIUrl":"https://doi.org/10.3731/JSSCR.V1I2.2662","url":null,"abstract":"Pain is an uncomfortable feeling caused by strong or destructive stimulation, if unchecked can affect daily routine. This study aims to determine the analgesic effect and dosage of the leaf extract ethanol, as well as to determine the effectiveness of the leaf extract ethanol as a narcotic analgesic by the Tail Flick method or as a non-narcotic analgesic by the Paw Pressure Test Randall Selitto method. Extraction was done by maceration of leaf powder with a solvent 96% ethanol. 25 male Wistar white rats were divided into 5 groups, positive group mefenamic acid 9 mg /200 g BW for the Paw Pressure Test Randall Selitto Method and tramadol 0.9 mg /200 g BW for the Tail Flick Method, negative control CMC Na 0,5%, ethanol extract leaves inggu leaves a dose of 10 mg /200 g BW, 20 mg /200 g BW and 40 mg /200 g BW. The data obtained were analyzed by ANOVA test, then LSD test was used to determine differences between groups. The results showed extract dosage of 10 mg /200 g BW, 20 mg /200 g BW, 40 mg /200 g BW had analgesic effect. Extract dosage of 20 mg /200 g BW and 40 mg /200 g BW in the Randall selitto Paw Pressure Test method is equivalent to mefenamic acid, extract dose 10 mg /200 g BW, 20 mg /200 g BW, and 40 mg /200 g BW the Tail Flick method is equivalent to Tramadol. Ethanol leaf extract is more effective as a narcotic analgesic by the Tail Flick method.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124536066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
TB is an infectious disease caused by Gercobacterium tuberculosis that attacks the lungs and can cause disturbances in the respiratory tract. The DOTS Program can help the achievement of successful treatment targets. The role and motivation of PMO and family are essential for the successful treatment of lung TB patients. This type of study is an analytical observational research with prospective data collection in March – May 2019, which is recorded as medical data of patients diagnosed with lung TB category I in September – November 2018 at Rubaru Puskesmas Sumenep Regency. The purpose of this research is to know the role of PMO relationship with the successful treatment of lung TB category I. With the number of samples of this research 40 patients. The results of this study using Pearson correlation statistics indicate that the value significance 0.013 < 0.05, this means a significant link between the PMO role with the success of patient treatment. The value of the correlation coefficient R obtained from 0388, the relationship between PMO role and the success of patient treatment in direct, this means that the greater the role of PMO then the higher the success of treatment, the smaller the PMO role then the lower the Successful treatment. In addition, the table also gained that the relationship between the PMO role and the successful treatment of the patient is weak due to the correlation coefficient of R < 0.4.
{"title":"Hubungan Antara Peran Pengawas Menelan Obat (PMO) dengan Keberhasilan Pengobatan Tuberkulosis Paru Kategori I","authors":"Selly Septi Fandinata, R. Darmawan","doi":"10.3731/JSSCR.V1I2.2664","DOIUrl":"https://doi.org/10.3731/JSSCR.V1I2.2664","url":null,"abstract":"TB is an infectious disease caused by Gercobacterium tuberculosis that attacks the lungs and can cause disturbances in the respiratory tract. The DOTS Program can help the achievement of successful treatment targets. The role and motivation of PMO and family are essential for the successful treatment of lung TB patients. This type of study is an analytical observational research with prospective data collection in March – May 2019, which is recorded as medical data of patients diagnosed with lung TB category I in September – November 2018 at Rubaru Puskesmas Sumenep Regency. The purpose of this research is to know the role of PMO relationship with the successful treatment of lung TB category I. With the number of samples of this research 40 patients. The results of this study using Pearson correlation statistics indicate that the value significance 0.013 < 0.05, this means a significant link between the PMO role with the success of patient treatment. The value of the correlation coefficient R obtained from 0388, the relationship between PMO role and the success of patient treatment in direct, this means that the greater the role of PMO then the higher the success of treatment, the smaller the PMO role then the lower the Successful treatment. In addition, the table also gained that the relationship between the PMO role and the successful treatment of the patient is weak due to the correlation coefficient of R < 0.4.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114861716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-06DOI: 10.37311/JSSCR.V1I2.2660
Muhamad Handoyo Sahumena, S. Suryani, Neni Rahmadani
Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) which has analgesic, anti-inflammatory and antipyretic effects. Mefenamic acid works by inhibiting prostaglandin synthesis as an inflammatory mediator. Mefenamic acid has low drug solubility and a long process of dissolution in the body which greatly affects the speed of absorption and bioavailability of the drug. In this study, mefenamic acid nanoemulsion formulation was carried out through a Self-Nanoemulsifying Drug Delivery System (SNEDDS) delivery system. SNEDDS is a drug delivery method through isotropic oil extraction, surfactants, cosurfactans and drug that form oil in water (m/a) emulsions which when in contact with the water phase in the digestive tract wiil from a nanoemulsion that occurs spontaneously so that the drug dissolves with a particle size small so as to increase the effective surface area for absorption. The purpose of the study was to determine the ratio of surfactant and cosurfactant composition to the optimum formula of SNEDDS of mefenamic acid with VCO as an oil phase. The SNEDDS formula was obtained by mixing the surfactants tween 80 and span 80, cosurfactant PEG 400 and VCO as the oil phase using the characterization of determining the optimum formula, namely emulsion formation, transmittance and emulsification time. The composition of the optimum formula of SNEDDS of mefenamic acid is 1 mL VCO; 1 mL PEG 400; 6 mL tween 80; 1 mL span 80. Optimum formula showed clear emulsion results, with transmittance values of 89,04% and emulsification time under 1 minute. In this study produced the optimum formula SNEDDS the met the criteria based on droplet size parameters of 153,5 nm, potential zeta value of 8,2 mV and showed good stability.
{"title":"Formulasi Self-Nanoemulsifiying Drug Delivery System (SNEDDS) Asam Mefenamat menggunakan VCO dengan Kombinasi Surfaktan Tween dan Span","authors":"Muhamad Handoyo Sahumena, S. Suryani, Neni Rahmadani","doi":"10.37311/JSSCR.V1I2.2660","DOIUrl":"https://doi.org/10.37311/JSSCR.V1I2.2660","url":null,"abstract":"Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID) which has analgesic, anti-inflammatory and antipyretic effects. Mefenamic acid works by inhibiting prostaglandin synthesis as an inflammatory mediator. Mefenamic acid has low drug solubility and a long process of dissolution in the body which greatly affects the speed of absorption and bioavailability of the drug. In this study, mefenamic acid nanoemulsion formulation was carried out through a Self-Nanoemulsifying Drug Delivery System (SNEDDS) delivery system. SNEDDS is a drug delivery method through isotropic oil extraction, surfactants, cosurfactans and drug that form oil in water (m/a) emulsions which when in contact with the water phase in the digestive tract wiil from a nanoemulsion that occurs spontaneously so that the drug dissolves with a particle size small so as to increase the effective surface area for absorption. The purpose of the study was to determine the ratio of surfactant and cosurfactant composition to the optimum formula of SNEDDS of mefenamic acid with VCO as an oil phase. The SNEDDS formula was obtained by mixing the surfactants tween 80 and span 80, cosurfactant PEG 400 and VCO as the oil phase using the characterization of determining the optimum formula, namely emulsion formation, transmittance and emulsification time. The composition of the optimum formula of SNEDDS of mefenamic acid is 1 mL VCO; 1 mL PEG 400; 6 mL tween 80; 1 mL span 80. Optimum formula showed clear emulsion results, with transmittance values of 89,04% and emulsification time under 1 minute. In this study produced the optimum formula SNEDDS the met the criteria based on droplet size parameters of 153,5 nm, potential zeta value of 8,2 mV and showed good stability.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115428090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-09-05DOI: 10.37311/JSSCR.V1I2.2661
Alfu Wa Ichda, Laksmi Maharani, M. W. Suryoputri
Penelitian ini bertujuan untuk mengetahui hubungan antara dukungan keluarga dengan kepatuhan pengobatan pasien rawat jalan skizofrenia di RSUD Banyumas. Teknik pengambilan sampel secara total sampling selama 1 bulan dengan jumlah 35 pasien dan caregiver. Dukungan keluarga diukur menggunakan Kuesioner Dukungan Keluarga dan kepatuhan pengobatan diukur menggunakan kuesioner MARS. Hasil penelitian dukungan keluarga diperoleh 94,3% caregiver memberikan dukungan tinggi dan 5,7% memberikan dukungan rendah, sedangkan kepatuhan pengobatan diperoleh 68,6% pasien memiliki kepatuhan tinggi, 25,7% kepatuhan sedang, dan 5,7% kepatuhan rendah. Hasil uji korelasi Spearman menunjukkan adanya hubungan yang bermakna antara kepatuhan pengobatan pasien rawat jalan skizofrenia (p
{"title":"Hubungan Dukungan Keluarga dengan Kepatuhan Pengobatan Pasien Rawat Jalan Skizofrenia di RSUD Banyumas","authors":"Alfu Wa Ichda, Laksmi Maharani, M. W. Suryoputri","doi":"10.37311/JSSCR.V1I2.2661","DOIUrl":"https://doi.org/10.37311/JSSCR.V1I2.2661","url":null,"abstract":"Penelitian ini bertujuan untuk mengetahui hubungan antara dukungan keluarga dengan kepatuhan pengobatan pasien rawat jalan skizofrenia di RSUD Banyumas. Teknik pengambilan sampel secara total sampling selama 1 bulan dengan jumlah 35 pasien dan caregiver. Dukungan keluarga diukur menggunakan Kuesioner Dukungan Keluarga dan kepatuhan pengobatan diukur menggunakan kuesioner MARS. Hasil penelitian dukungan keluarga diperoleh 94,3% caregiver memberikan dukungan tinggi dan 5,7% memberikan dukungan rendah, sedangkan kepatuhan pengobatan diperoleh 68,6% pasien memiliki kepatuhan tinggi, 25,7% kepatuhan sedang, dan 5,7% kepatuhan rendah. Hasil uji korelasi Spearman menunjukkan adanya hubungan yang bermakna antara kepatuhan pengobatan pasien rawat jalan skizofrenia (p","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"540 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133903016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-03-01DOI: 10.37311/jsscr.v1i1.2199
Muhammad Taupik, M.Sc, Muhammad Adam Mustapa
Waru (Hibiscustiliaceus L.) bark is a plant that is believed and used by community as a traditional medicine in treatment, especiallytotreat fever. This study aims to analyze the level of a secondary metabolite compound in the bark of waru (Hibiscustiliaceus L.) plant calculated using UV-Vis spectrophotometry and infrared methods. The method used to identify the flavonoid content is Thin Layer Chromatography (TLC) using eluent n-hexane and ethyl acetate at the best comparison (7:3). The result obtained from this study is waru bark extract containing flavonoid compound which is shown from the Rf value of the waru bark methanol extract of 0.82, which the value is close to the Rf value of quarcetine 0.83. Analysis of the flavonoid content of waru bark methanol extract has carried out on The Spectrophotometric UV-Vis at a wavelength of 382 nm and the total flavonoid content obtained is of 10 mg of waru bark methanol extract containing135.2166g/mL flavonoid compound with percentage of 13.521% and on the Spetroscopy Infrared, based on the obtained peak shows the existence of functional groups of OH, CH aliphatic, C=C aromatic and C-O indicates that this isolat is a flavonoid compound.
{"title":"IDENTIFIKASI ISOLAT KULIT BATANG WARU (Hibiscus tiliaceus L.) MENGGUNAKAN SPEKTROSKOPI INFRAMERAH","authors":"Muhammad Taupik, M.Sc, Muhammad Adam Mustapa","doi":"10.37311/jsscr.v1i1.2199","DOIUrl":"https://doi.org/10.37311/jsscr.v1i1.2199","url":null,"abstract":"Waru (Hibiscustiliaceus L.) bark is a plant that is believed and used by community as a traditional medicine in treatment, especiallytotreat fever. This study aims to analyze the level of a secondary metabolite compound in the bark of waru (Hibiscustiliaceus L.) plant calculated using UV-Vis spectrophotometry and infrared methods. The method used to identify the flavonoid content is Thin Layer Chromatography (TLC) using eluent n-hexane and ethyl acetate at the best comparison (7:3). The result obtained from this study is waru bark extract containing flavonoid compound which is shown from the Rf value of the waru bark methanol extract of 0.82, which the value is close to the Rf value of quarcetine 0.83. Analysis of the flavonoid content of waru bark methanol extract has carried out on The Spectrophotometric UV-Vis at a wavelength of 382 nm and the total flavonoid content obtained is of 10 mg of waru bark methanol extract containing135.2166g/mL flavonoid compound with percentage of 13.521% and on the Spetroscopy Infrared, based on the obtained peak shows the existence of functional groups of OH, CH aliphatic, C=C aromatic and C-O indicates that this isolat is a flavonoid compound.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"329 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133678734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：