Pub Date : 2022-02-09DOI: 10.37311/jsscr.v4i1.13512
Muthmainna B, Ardilla Amra
pH is an important parameter in cosmetic products because it is very high or low pH can caused skin irritation. SPF (Sun Protecting Factor) is a universal indicator that describes the effectiveness of a product or substance that is UV protector. The Moringa plant which has a Latin name called Moringa oleifera or in English it is called a drumstick plant is a plant that is a vegetable that is full of nutrients and has various types of uses. This study aims to determine the pH levels and SPF (Sun Protecting Factor) values contained in the sunblock cream of Moringa leaf extract (Moringa oleifera L.). In this study, pH levels were tested by weighing sunblock cream with a concentration of 1%, 3%, 5% then dissolved into aquadest and then tested for pH levels using a pH meter which resulted in pH levels of 6.89 for a concentration of 1%, 6.73 for a concentration of 3% and 6.60 for 5% concentration. While the determination of the SPF (Sun Protecting Factor) value was carried out by weighing the sunblock cream with a concentration of 1%, 3%, 5% then dissolved in ethanol then precipitated using a centrifuge and the absorption was measured using a spectrophotometer which resulted in a SPF (Sun Protecting Factor) value of 7.012 with the category of extra protection, for 1% concentration that 7.275 with extra protection category for 3% concentration and 9.397 with maximum protection for 5% concentration.
{"title":"Uji pH dan Nilai SPF ( Sun Protecting Factor) Terhadap Krim Sunblock Ekstrak Daun Kelor (Moringa oleifera L.)","authors":"Muthmainna B, Ardilla Amra","doi":"10.37311/jsscr.v4i1.13512","DOIUrl":"https://doi.org/10.37311/jsscr.v4i1.13512","url":null,"abstract":"pH is an important parameter in cosmetic products because it is very high or low pH can caused skin irritation. SPF (Sun Protecting Factor) is a universal indicator that describes the effectiveness of a product or substance that is UV protector. The Moringa plant which has a Latin name called Moringa oleifera or in English it is called a drumstick plant is a plant that is a vegetable that is full of nutrients and has various types of uses. This study aims to determine the pH levels and SPF (Sun Protecting Factor) values contained in the sunblock cream of Moringa leaf extract (Moringa oleifera L.). In this study, pH levels were tested by weighing sunblock cream with a concentration of 1%, 3%, 5% then dissolved into aquadest and then tested for pH levels using a pH meter which resulted in pH levels of 6.89 for a concentration of 1%, 6.73 for a concentration of 3% and 6.60 for 5% concentration. While the determination of the SPF (Sun Protecting Factor) value was carried out by weighing the sunblock cream with a concentration of 1%, 3%, 5% then dissolved in ethanol then precipitated using a centrifuge and the absorption was measured using a spectrophotometer which resulted in a SPF (Sun Protecting Factor) value of 7.012 with the category of extra protection, for 1% concentration that 7.275 with extra protection category for 3% concentration and 9.397 with maximum protection for 5% concentration.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126714451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-09DOI: 10.37311/jsscr.v4i1.13519
Yusnita Usman
Research has been carried out on formulation and stability test of hand body lotion from ethanolic extract of seaweed (Euchema cottonii). This study aims to obtain a hand body lotion formulation from seaweed extract (Eucheuma cottonii) that meets the requirements for the physical quality of the lotion, where the formula made consists of 4 formulas with extract concentrations of 5%, 10%, 15% and formulas without extracts. The evaluation of lotion preparations included organoleptic tests, pH tests, homogeneity tests and dispersibility tests. Data analysis was carried out by testing the physical quality of each formula compared to the quality standard of lotion preparations according to theory. From the research that has been done, it shows that the composition of the 4 formulas shows homogeneous results. The pH values of the formulas with extract concentrations of 5%, 10% and 5% and formulas without extracts were 5,8;5,3;5,1 and 6.6 (quality requirements 4,5 -6.6). Meanwhile, the pH distribution of the formula with 5%, 10% and 5% extract concentrations and the formula without extract was 5.2, respectively; 4.8; 4,4 and 5 (quality requirements 5-7). Based on the results obtained, it can be concluded that the formula with an extract concentration of 5% has the most physical stability that meets the requirements for the quality of lotion preparations.
{"title":"Formulasi dan Uji Stabilitas Hand Body Lotion dari Ekstrak Etanol Rumput Laut (Eucheuma cottonii)","authors":"Yusnita Usman","doi":"10.37311/jsscr.v4i1.13519","DOIUrl":"https://doi.org/10.37311/jsscr.v4i1.13519","url":null,"abstract":"Research has been carried out on formulation and stability test of hand body lotion from ethanolic extract of seaweed (Euchema cottonii). This study aims to obtain a hand body lotion formulation from seaweed extract (Eucheuma cottonii) that meets the requirements for the physical quality of the lotion, where the formula made consists of 4 formulas with extract concentrations of 5%, 10%, 15% and formulas without extracts. The evaluation of lotion preparations included organoleptic tests, pH tests, homogeneity tests and dispersibility tests. Data analysis was carried out by testing the physical quality of each formula compared to the quality standard of lotion preparations according to theory. From the research that has been done, it shows that the composition of the 4 formulas shows homogeneous results. The pH values of the formulas with extract concentrations of 5%, 10% and 5% and formulas without extracts were 5,8;5,3;5,1 and 6.6 (quality requirements 4,5 -6.6). Meanwhile, the pH distribution of the formula with 5%, 10% and 5% extract concentrations and the formula without extract was 5.2, respectively; 4.8; 4,4 and 5 (quality requirements 5-7). Based on the results obtained, it can be concluded that the formula with an extract concentration of 5% has the most physical stability that meets the requirements for the quality of lotion preparations.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122248231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-08DOI: 10.37311/jsscr.v4i1.13507
S. Suryanita, Ferna Indrayani, Muhammad Asri
Research has been carried out on the effect of giving ethanol extract of red spinach (Amaranthus tricolor L.) on blood glucose of male white rats (Rattus novergicus) exposed to cigarette smoke for an interval of 15 days with the administration of ethanolic extract of red spinach. This study aims to determine the effect of ethanol extract on blood glucose levels of male white rats which were divided into 4 groups. Group I as a positive control that was not given any treatment, group II was given ethanolic extract of red spinach 200 mg/kg BW, group III was given ethanolic extract of red spinach 400 mg/kg BW, and group IV as a negative control was only given cigarette smoke exposure without any treatment. extract administration. From the research that has been done, the results of the decrease in blood glucose in group I is 63,3 mg/dl, group II is 98 mg/dl, group III is 116 mg/dl, and group IV is 155 mg/dl. Based on the results obtained, it can be concluded that the decrease in blood glucose caused The most effective is red spinach ethanol extract with a concentration of 200 mg/kg BW, which is 98 mg/dl.
{"title":"Efektivitas ekstrak etanol bayam merah (amaranthus tricolor l.) Terhadap glukosa darah Tikus putih ( rattus novergicus) jantan Yang dipapar dengan asap rokok","authors":"S. Suryanita, Ferna Indrayani, Muhammad Asri","doi":"10.37311/jsscr.v4i1.13507","DOIUrl":"https://doi.org/10.37311/jsscr.v4i1.13507","url":null,"abstract":"Research has been carried out on the effect of giving ethanol extract of red spinach (Amaranthus tricolor L.) on blood glucose of male white rats (Rattus novergicus) exposed to cigarette smoke for an interval of 15 days with the administration of ethanolic extract of red spinach. This study aims to determine the effect of ethanol extract on blood glucose levels of male white rats which were divided into 4 groups. Group I as a positive control that was not given any treatment, group II was given ethanolic extract of red spinach 200 mg/kg BW, group III was given ethanolic extract of red spinach 400 mg/kg BW, and group IV as a negative control was only given cigarette smoke exposure without any treatment. extract administration. From the research that has been done, the results of the decrease in blood glucose in group I is 63,3 mg/dl, group II is 98 mg/dl, group III is 116 mg/dl, and group IV is 155 mg/dl. Based on the results obtained, it can be concluded that the decrease in blood glucose caused The most effective is red spinach ethanol extract with a concentration of 200 mg/kg BW, which is 98 mg/dl.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121465546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laparotomy is a major operation and causes a lot of injuries, so the risk of infection of the laparotomy surgery wound is quite high. Surgical Site Infection (ILO) or Surgical Site Infection (ITP). Prevention of postoperative infection in patients with clean-contaminated surgery, and some clean operations with the use of prophylactic antibiotics. The purpose of this study was to evaluate the use of prophylactic antibiotics in patients with laparotomy surgery in a hospital in Surabaya. The research method is descriptive operational with retrospective data. The results of this study obtained as many as 160 patients aged 46-55 years at 20.6%, the sex of the respondents were dominated by male sex 66.3%, and the diagnosis of generalized peritonitis was 46.9%. The use of prophylactic antibiotics is class I cephalosporin antibiotics (cefazolin) with a dose of 1000-2000 mg, which is by the 2011 Ministry of Health guidelines.
{"title":"Evaluasi Penggunaan Antibiotika Profilaksis Operasi Digestif Laparatomi di Rumah Sakit Kota Surabaya","authors":"Selly Septi Fandinata, Eziah Ika Lubada, Ilil Maidatuz Zulfa","doi":"10.37311/jsscr.v4i1.13496","DOIUrl":"https://doi.org/10.37311/jsscr.v4i1.13496","url":null,"abstract":"Laparotomy is a major operation and causes a lot of injuries, so the risk of infection of the laparotomy surgery wound is quite high. Surgical Site Infection (ILO) or Surgical Site Infection (ITP). Prevention of postoperative infection in patients with clean-contaminated surgery, and some clean operations with the use of prophylactic antibiotics. The purpose of this study was to evaluate the use of prophylactic antibiotics in patients with laparotomy surgery in a hospital in Surabaya. The research method is descriptive operational with retrospective data. The results of this study obtained as many as 160 patients aged 46-55 years at 20.6%, the sex of the respondents were dominated by male sex 66.3%, and the diagnosis of generalized peritonitis was 46.9%. The use of prophylactic antibiotics is class I cephalosporin antibiotics (cefazolin) with a dose of 1000-2000 mg, which is by the 2011 Ministry of Health guidelines.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133662524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dyslipidemia is an abnormality of lipids in the blood, including a decrease in HDL levels and an increase in triglyceride levels, LDL levels and total cholesterol. The high concentration of cholesterol in the blood is one of the causes of atherosclerosis and can further cause hypertension and coronary heart disease. The use of synthetic drugs in the long term can cause unwanted side effects. This study aims to examine the effect of increasing HDL cholesterol levels, decreasing total cholesterol and LDL cholesterol levels from the ethanol extract of Clitoria ternatea L using male rats (Rattus norvegicus). This study used the maceration method of Clitoria ternatea L. then the thick extract obtained was tested for its activity which was divided into 6 treatment groups namely normal control group, positive control, negative control, dose 1 (extract 100 mg/kgBB), dose 1 2 (extract 200 mg/kgBB) and dose 3 (extract 400 mg/kgBB) were then measured for total cholesterol, HDL and LDL. The results showed that the administration of ethanol extract of Clitoria ternatea L was able to reduce total cholesterol levels, LDL and increase HDL levels in male rats. The dose of ethanol extract of Clitoria ternatea L that was most effective in reducing total and LDL cholesterol levels and increasing HDL levels in rats that had been induced by a high-fat diet was dose 3, namely extract 400mg/kgBB.
{"title":"Efek Bunga Telang (Clitoria ternatea L.) Terhadap Kolesterol Total, LDL, HDL Pada Tikus (Rattus Norvegicus )","authors":"Yustiyani Arifah, Sunarti Sunarti, Rani Prabandari","doi":"10.37311/jsscr.v4i1.13493","DOIUrl":"https://doi.org/10.37311/jsscr.v4i1.13493","url":null,"abstract":"Dyslipidemia is an abnormality of lipids in the blood, including a decrease in HDL levels and an increase in triglyceride levels, LDL levels and total cholesterol. The high concentration of cholesterol in the blood is one of the causes of atherosclerosis and can further cause hypertension and coronary heart disease. The use of synthetic drugs in the long term can cause unwanted side effects. This study aims to examine the effect of increasing HDL cholesterol levels, decreasing total cholesterol and LDL cholesterol levels from the ethanol extract of Clitoria ternatea L using male rats (Rattus norvegicus). This study used the maceration method of Clitoria ternatea L. then the thick extract obtained was tested for its activity which was divided into 6 treatment groups namely normal control group, positive control, negative control, dose 1 (extract 100 mg/kgBB), dose 1 2 (extract 200 mg/kgBB) and dose 3 (extract 400 mg/kgBB) were then measured for total cholesterol, HDL and LDL. The results showed that the administration of ethanol extract of Clitoria ternatea L was able to reduce total cholesterol levels, LDL and increase HDL levels in male rats. The dose of ethanol extract of Clitoria ternatea L that was most effective in reducing total and LDL cholesterol levels and increasing HDL levels in rats that had been induced by a high-fat diet was dose 3, namely extract 400mg/kgBB.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124250796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-06DOI: 10.37311/jsscr.v4i1.13484
P. Parawansah, Nuralifah Nuralifah, Yulfa Yulfa
Dyslipidemia is an abnormality of lipids in the blood, including a decrease in HDL levels and an increase in triglyceride levels, LDL levels and total cholesterol. The high concentration of cholesterol in the blood is one of the causes of atherosclerosis and can further cause hypertension and coronary heart disease. The use of synthetic drugs in the long term can cause unwanted side effects. This study aims to examine the effect of increasing HDL cholesterol levels, decreasing total cholesterol and LDL cholesterol levels from the ethanol extract of Clitoria ternatea L using male rats (Rattus norvegicus). This study used the maceration method of Clitoria ternatea L. then the thick extract obtained was tested for its activity which was divided into 6 treatment groups namely normal control group, positive control, negative control, dose 1 (extract 100 mg/kgBB), dose 1 2 (extract 200 mg/kgBB) and dose 3 (extract 400 mg/kgBB) were then measured for total cholesterol, HDL and LDL. The results showed that the administration of ethanol extract of Clitoria ternatea L was able to reduce total cholesterol levels, LDL and increase HDL levels in male rats. The dose of ethanol extract of Clitoria ternatea L that was most effective in reducing total and LDL cholesterol levels and increasing HDL levels in rats that had been induced by a high-fat diet was dose 3, namely extract 400mg/kgBB.
{"title":"FRAKSI EKSTRAK ETANOL BUAH PARE (Mommordica charantia L.) SEBAGAI ANTIINFLAMASI TERHADAP KADAR TUMOR NECROSIS FACTOR ALPHA (TNF-α)","authors":"P. Parawansah, Nuralifah Nuralifah, Yulfa Yulfa","doi":"10.37311/jsscr.v4i1.13484","DOIUrl":"https://doi.org/10.37311/jsscr.v4i1.13484","url":null,"abstract":"Dyslipidemia is an abnormality of lipids in the blood, including a decrease in HDL levels and an increase in triglyceride levels, LDL levels and total cholesterol. The high concentration of cholesterol in the blood is one of the causes of atherosclerosis and can further cause hypertension and coronary heart disease. The use of synthetic drugs in the long term can cause unwanted side effects. This study aims to examine the effect of increasing HDL cholesterol levels, decreasing total cholesterol and LDL cholesterol levels from the ethanol extract of Clitoria ternatea L using male rats (Rattus norvegicus). This study used the maceration method of Clitoria ternatea L. then the thick extract obtained was tested for its activity which was divided into 6 treatment groups namely normal control group, positive control, negative control, dose 1 (extract 100 mg/kgBB), dose 1 2 (extract 200 mg/kgBB) and dose 3 (extract 400 mg/kgBB) were then measured for total cholesterol, HDL and LDL. The results showed that the administration of ethanol extract of Clitoria ternatea L was able to reduce total cholesterol levels, LDL and increase HDL levels in male rats. The dose of ethanol extract of Clitoria ternatea L that was most effective in reducing total and LDL cholesterol levels and increasing HDL levels in rats that had been induced by a high-fat diet was dose 3, namely extract 400mg/kgBB.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128120636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-04DOI: 10.37311/jsscr.v4i1.13483
Elis Susilawati, ED. Yunisa M.P, Deti Siti Fatimah
Storage is one of the main factors in the maintenance of drug quality by storing properly and in accordance with standards, if it is not done will cause the quality of the drug is not guaranteed during storage in pharmacies. This study aims to find out how to store drugs and how much percentage of suitability of drug storage systems in one of Cimahi City Pharmacies Based on the Technical Instructions for Pharmaceutical Service Standards in Pharmacies in 2019. Research methods use descriptive observation and evaluation using checklist table sheets. Drug storage in one of Cimahi City Pharmacies is stored based on dosage form, therapeutic class, stability and alphabetically with a dispensing system using the FEFO system. Drug storage systems in pharmacies in accordance with the Technical Instructions of Pharmaceutical Service Standards are 86.36% while those that are not in accordance with the Technical Instructions of Pharmaceutical Service Standards which amount to 13.64% include adjacent LASA or NORUM storage, recording on less than optimal stock cards and the absence of backup electricity. The conclusion of this study shows that there are still those who are not in accordance with the Technical Instructions of Pharmaceutical Service Standards.
{"title":"EVALUASI KESESUAIAN PENYIMPANAN OBAT DI SALAH SATU APOTEK KOTA CIMAHI","authors":"Elis Susilawati, ED. Yunisa M.P, Deti Siti Fatimah","doi":"10.37311/jsscr.v4i1.13483","DOIUrl":"https://doi.org/10.37311/jsscr.v4i1.13483","url":null,"abstract":"Storage is one of the main factors in the maintenance of drug quality by storing properly and in accordance with standards, if it is not done will cause the quality of the drug is not guaranteed during storage in pharmacies. This study aims to find out how to store drugs and how much percentage of suitability of drug storage systems in one of Cimahi City Pharmacies Based on the Technical Instructions for Pharmaceutical Service Standards in Pharmacies in 2019. Research methods use descriptive observation and evaluation using checklist table sheets. Drug storage in one of Cimahi City Pharmacies is stored based on dosage form, therapeutic class, stability and alphabetically with a dispensing system using the FEFO system. Drug storage systems in pharmacies in accordance with the Technical Instructions of Pharmaceutical Service Standards are 86.36% while those that are not in accordance with the Technical Instructions of Pharmaceutical Service Standards which amount to 13.64% include adjacent LASA or NORUM storage, recording on less than optimal stock cards and the absence of backup electricity. The conclusion of this study shows that there are still those who are not in accordance with the Technical Instructions of Pharmaceutical Service Standards.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128385012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-30DOI: 10.37311/jsscr.v4i1.13310
Fahmi Sadik, A. Rifqah Amalia Anwar
Gotu kola (Centella asiatica L.) is empirically used as a medicinal plant and scientifically it can be used to treat various diseases based on the results of the Scientification of Herbal Medicine. Gotu kola leaf (Centella asiatica L.) is one of the potential medicinal plants that can be used as herbal medicine because it contains various kinds of nutritious compounds. Because of the many benefits of gotu kola leaves, it is necessary to standardize the extract to ensure the quality associated with the identity substance, and the composition of the chemical content whose specifications are stated in the monograph as a quality requirement listed in Materia Medika Indonesia. Standardization includes organoleptic test, identification of chemical content, determination of water soluble extract content, ethanol soluble extract content and other tests, namely seeing the activity of gotu kola as an antidiabetic. The results and data on the characteristics of the specific parameters indicated that the extracts made had met the requirements of the herbal pharmacopoeia, which means that the ethanolic extract of gotu kola had met the standards, and based on activity testing it was known that the leaf of gotu kola (Centella asiatica L.) was efficacious as antidiabetic.
{"title":"Standarisasi Parameter Spesifik Ekstrak Etanol Daun Pegagan (Centella asiatica L.) Sebagai Antidiabetes","authors":"Fahmi Sadik, A. Rifqah Amalia Anwar","doi":"10.37311/jsscr.v4i1.13310","DOIUrl":"https://doi.org/10.37311/jsscr.v4i1.13310","url":null,"abstract":"Gotu kola (Centella asiatica L.) is empirically used as a medicinal plant and scientifically it can be used to treat various diseases based on the results of the Scientification of Herbal Medicine. Gotu kola leaf (Centella asiatica L.) is one of the potential medicinal plants that can be used as herbal medicine because it contains various kinds of nutritious compounds. Because of the many benefits of gotu kola leaves, it is necessary to standardize the extract to ensure the quality associated with the identity substance, and the composition of the chemical content whose specifications are stated in the monograph as a quality requirement listed in Materia Medika Indonesia. Standardization includes organoleptic test, identification of chemical content, determination of water soluble extract content, ethanol soluble extract content and other tests, namely seeing the activity of gotu kola as an antidiabetic. The results and data on the characteristics of the specific parameters indicated that the extracts made had met the requirements of the herbal pharmacopoeia, which means that the ethanolic extract of gotu kola had met the standards, and based on activity testing it was known that the leaf of gotu kola (Centella asiatica L.) was efficacious as antidiabetic.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"38 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132118483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-08DOI: 10.37311/jsscr.v3i2.11914
Gabena Indrayani Dalimunthe, Ricky Andi Ayaputra
Diclofenac sodium is a Transfersom is a transdermal delivery system consisting of phospholipids and edge activators. Transfersom increases the size of the stratum corneum lipid barrier pores, then enters the skin through the drive of the trans-barrier motion and squeezes itself to follow the lipid barrier pore size. The purpose of this study is to determine the effect of the tween-80 concentration as an edge activator on the characteristics and diffusion rate of diclofenac sodium transfersom. Transferom preparation used the vortex-sonication method which was made in five formulae with variations in the concentration ratio of phosphatidylcholine and tween-80 (95:05, 90:10, 85:15, 80:20, and 75:25). The results show that all five formulae have different morphological forms. The results of statistical tests using One-Way ANOVA finds a significant effect (p-value) of the edge activator concentration on the diffusion rate of diclofenac sodium transfersom.
{"title":"Edge Activator: Effect of Concentration Variation of Tween 80 on Characteristics and Rate of Difusion transfersome sodium diclofenac","authors":"Gabena Indrayani Dalimunthe, Ricky Andi Ayaputra","doi":"10.37311/jsscr.v3i2.11914","DOIUrl":"https://doi.org/10.37311/jsscr.v3i2.11914","url":null,"abstract":"Diclofenac sodium is a Transfersom is a transdermal delivery system consisting of phospholipids and edge activators. Transfersom increases the size of the stratum corneum lipid barrier pores, then enters the skin through the drive of the trans-barrier motion and squeezes itself to follow the lipid barrier pore size. The purpose of this study is to determine the effect of the tween-80 concentration as an edge activator on the characteristics and diffusion rate of diclofenac sodium transfersom. Transferom preparation used the vortex-sonication method which was made in five formulae with variations in the concentration ratio of phosphatidylcholine and tween-80 (95:05, 90:10, 85:15, 80:20, and 75:25). The results show that all five formulae have different morphological forms. The results of statistical tests using One-Way ANOVA finds a significant effect (p-value) of the edge activator concentration on the diffusion rate of diclofenac sodium transfersom.","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"220 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127526307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-08DOI: 10.37311/jsscr.v3i2.7041
Zulmai Rani, Robiatun Rambe
Dayak Onions are a typical Borneo plant that have been used by generations of Dayaks as herbal medicine. Empirically, tubers can be used as cough medicines. The purpose of this study was to determine the mucolytic effect of Dayak onion tuber extract by in vitro and the concentration range which gaves an equivalent effect with the effect of 0.1% acetylcysteine. This study conducted extraction using maceration and mucolytic effectiveness by in vitro to reduce the viscosity of cattle mucus. The test solution was made with a concentration of 0.5%, 1%, and 1.5% mixed with a mucus-phosphate buffer pH 7 20:80. The test solution was incubated for 30 minutes at 37oC. Further, positive control used was 0.1% acetylcysteine drug and the negative control was mucus solution without extract. Viscosity values obtained were analyzed using the One-way Anova statistical test with a confidence level of 99% (α 0.01). Based on the results, it was revealed that the extract of Dayak tuber with a concentration of 0.5%, 1%, and 1.5% showed a significant difference and a concentration of 0.5%. Mucolytic effectiveness was better than positive controls (acetylcysteine).
{"title":"UJI EFEKTIVITAS MUKOLITIK EKSTRAK UMBI BAWANG DAYAK (Eleuherine bulbosa (Mill) Urb) SECARA IN VITRO PADA USUS SAPI","authors":"Zulmai Rani, Robiatun Rambe","doi":"10.37311/jsscr.v3i2.7041","DOIUrl":"https://doi.org/10.37311/jsscr.v3i2.7041","url":null,"abstract":"Dayak Onions are a typical Borneo plant that have been used by generations of Dayaks as herbal medicine. Empirically, tubers can be used as cough medicines. The purpose of this study was to determine the mucolytic effect of Dayak onion tuber extract by in vitro and the concentration range which gaves an equivalent effect with the effect of 0.1% acetylcysteine. This study conducted extraction using maceration and mucolytic effectiveness by in vitro to reduce the viscosity of cattle mucus. The test solution was made with a concentration of 0.5%, 1%, and 1.5% mixed with a mucus-phosphate buffer pH 7 20:80. The test solution was incubated for 30 minutes at 37oC. Further, positive control used was 0.1% acetylcysteine drug and the negative control was mucus solution without extract. Viscosity values obtained were analyzed using the One-way Anova statistical test with a confidence level of 99% (α 0.01). Based on the results, it was revealed that the extract of Dayak tuber with a concentration of 0.5%, 1%, and 1.5% showed a significant difference and a concentration of 0.5%. Mucolytic effectiveness was better than positive controls (acetylcysteine).","PeriodicalId":257265,"journal":{"name":"Journal Syifa Sciences and Clinical Research","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133906239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：