Chinese Journal of Analytical Chemistry最新文献_第2页

Simultaneous detection of Ti/Zn content in sunscreens using calcination-assisted fiber laser induced breakdown spectroscopy 煅烧辅助光纤激光诱导击穿光谱法同时检测防晒霜中Ti/Zn含量

IF 1.3 4区化学 Q4 CHEMISTRY, ANALYTICAL

Chinese Journal of Analytical Chemistry

Pub Date : 2025-11-01 DOI: 10.1016/j.cjac.2025.100598

Shudi ZHANG , Qingtian XIAO , Binbin XU , Fangfang CHEN , Gueyhorng WANG , Zhisen LIANG , Zhouyi XU

An acid-free, simple and cost-effective laser induced breakdown spectroscopy (LIBS) analytical strategy was proposed to detect TiO₂/ZnO content in sunscreens by a low-irradiance fiber laser (0.15 GW/cm²). Samples and standards, which were simply prepared by mixing pure TiO₂/ZnO with different ratios, were incinerated and pressed into tablets and analyzed by normal calibration curve method and modified one-point multi-line calibration (OP-MLC) methods. Analytical performance of calibration curve linearity, limit of detection (LOD) and recovery rate (RR) was evaluated, and method validation was carried out by comparing detection results of commercial products with those from routine methods and calculating the detection precision (relative standard deviation) and accuracy (relative quantification error). By normal LIBS method, Calibration curve linearity generally reached the level of 0.99, and LOD and RR were evaluated to be 0.046 mg/g and 119.5 % for Ti and 0.473 mg/g and 115.0 % for Zn, which is sufficient in analyzing commercial sunscreen products. However, its precision (12.88 %) and accuracy (23.82 %) were relatively low, which was ascribed to the matrix effect derived from the difference of TiO₂ concentration after examining the ablation spot, plasma temperature and electron density. To correct it, the modified OP-MLC method took the plasma parameters into calculation, which resulted in better RR (101.09 % for Ti and 97.30 % for Zn) and nearly two times of precision (7.77 %) and accuracy (11.16 %) improvement than normal LIBS method due to the application of multiple lines to resist the signal fluctuation of repetitive measurements. However, it may not be applicable when detecting analytes of low concentration due to the potential disappearance of low intensity lines. Therefore, the combination of these two methods is viable to perform successful determination of Ti/Zn contents in sunscreens.

提出了一种无酸、简单、经济的激光诱导击穿光谱（LIBS）分析方法，利用低辐照光纤激光器（0.15 GW/cm2）检测防晒霜中TiO2/ZnO的含量。将不同配比的纯TiO2/ZnO简单混合制备样品和标准品，焚烧压制成片剂，采用常规校准曲线法和改进的一点多线校准（OP-MLC）法进行分析。评价了标准曲线的线性度、检出限（LOD）和回收率（RR）的分析性能，并通过将商品产品的检测结果与常规方法的检测结果进行比较，计算检测精密度（相对标准偏差）和准确度（相对定量误差），对方法进行验证。通过常规的LIBS方法，校正曲线的线性度一般达到0.99水平，对Ti的LOD和RR分别为0.046 mg/g和119.5 %，对Zn的LOD和RR分别为0.473 mg/g和115.0 %，足以用于商品防晒产品的分析。然而，其精密度（12.88 %）和准确度（23.82 %）相对较低，这是由于检测烧蚀点、等离子体温度和电子密度后TiO2浓度差异引起的基质效应。为了纠正这一错误，改进的OP-MLC方法将等离子体参数纳入计算，结果表明，由于采用了多条线来抵抗重复测量的信号波动，该方法的RR （Ti为101.09 %，Zn为97.30 %）和精密度（7.77 %）比普通LIBS方法提高了近两倍，准确度（11.16 %）提高了近两倍。但是，由于低强度谱线的潜在消失，它可能不适用于检测低浓度的分析物。因此，这两种方法的结合是可行的，可以成功地测定防晒霜中Ti/Zn的含量。

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引用次数: 0

Isolation and structural elucidation of an unknown novel impurity in sulfasalazine by high performance liquid chromatography coupled to mass spectroscopy and toxicology prediction 高效液相色谱-质谱联用及毒理学预测对磺胺嘧啶中一种未知新杂质的分离和结构解析

IF 1.3 4区化学 Q4 CHEMISTRY, ANALYTICAL

Chinese Journal of Analytical Chemistry

Pub Date : 2025-11-01 DOI: 10.1016/j.cjac.2025.100601

K. Krishna MOHAN , T.B. PATRUDU , Gowri Sankararao BURLE , Suresh SALAKOLUSU , Pericharla Venkata Narasimha RAJU , Sreekantha Babu JONNALAGADDA , Naresh Kumar KATARI

Sulfasalazine is authorised for the management of long-term inflammatory conditions, including ulcerative colitis as well as juvenile and adult rheumatoid arthritis. Using high performance liquid chromatography analysis, one unknown impurity with a level greater than 0.2% was found in prototype batches of sulfasalazine during production. The intended impurity under investigation eluted at retention time of around 33 min and had a relative retention time value of 1.79. Preparative high performance liquid chromatogram was used to isolate this unknown impurity from the crude sulfasalazine. A thorough examination of the ¹H-nuclear magnetic resonance spectroscopy (¹H-NMR) and mass spectrometry (MS) data revealed the structure of the novel impurity. The management of new impurity creation and the potential molecular pathways leading to its formation were also examined. A new sulfasalazine impurity was characterized and toxicology prediction data was also obtained.

磺胺吡啶被授权用于治疗长期炎症，包括溃疡性结肠炎以及青少年和成人类风湿性关节炎。采用高效液相色谱法分析，在磺胺霉嗪样品批次中发现1个含量大于0.2%的未知杂质。所研究的杂质在保留时间约为33分钟时被洗脱，相对保留时间值为1.79。采用制备型高效液相色谱法从磺胺嘧啶粗品中分离出该未知杂质。对核磁共振波谱（1H-NMR）和质谱（MS）数据的彻底检查揭示了新杂质的结构。新杂质产生的管理和导致其形成的潜在分子途径也进行了检查。对一种新的磺胺嘧啶杂质进行了表征，并获得了毒理学预测数据。

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引用次数: 0

Quantitative determination of coptisine and berberine hydrochloride in Corydalis conspersa by high-performance liquid chromatography and quality evaluation 高效液相色谱法定量测定黄连素和盐酸小檗碱的含量

IF 1.3 4区化学 Q4 CHEMISTRY, ANALYTICAL

Chinese Journal of Analytical Chemistry

Pub Date : 2025-10-01 DOI: 10.1016/j.cjac.2025.100620

DU Qing

The key active ingredients of Chinese medicinal materials are often used as indicators in quality standards. Corydalis conspersa is a characteristic plant from the Qinghai-Tibet plateau and contains various of isoquinoline alkaloids. Water content was determinated from diverse parts of Corydalis conspersa according to the Chinese Pharmacopoeia. The component of coptisine and berberine hydrochloride in Corydalis conspersa were extracted using the solvent of methanol-hydrochloric acid and detected by high-performance liquid chromatography. The results of method validation test was stable and reliable. The content of coptisine and berberine hydrochloride in root samples was higher than in herbs. In the sample solutions of stem and leaf, only coptisine was detectable. Thus, the levels of coptisine and berberine hydrochloride in root and herbs can serve as a qualified basis for quality standards of Corydalis conspersa.

中药材的关键有效成分常作为质量标准的指标。根据《中国药典》的规定，测定了延胡索各部位的水分含量。采用甲醇-盐酸溶剂提取延胡索中的黄连碱和盐酸小檗碱成分，并采用高效液相色谱法进行检测。方法验证试验结果稳定可靠。根样品中黄连碱和盐酸小檗碱的含量高于中草药。茎、叶样品溶液中仅检出黄连碱。因此，根和药材中黄连碱和盐酸小檗碱的含量可作为延胡索质量标准的合格依据。

引用次数: 0

Recent advances in antioxidant cerium-based nanozymes: Catalytic mechanisms and bioanalysis/biomedical applications 抗氧化铈基纳米酶的最新进展：催化机制和生物分析/生物医学应用

IF 1.3 4区化学 Q4 CHEMISTRY, ANALYTICAL

Chinese Journal of Analytical Chemistry

Pub Date : 2025-09-28 DOI: 10.1016/j.cjac.2025.100640

Mingxi XIA , Litao GE , Alexandr ROGACHEV , Zijian WANG , Huilin WANG

Antioxidant enzymes serve as crucial reactive oxygen species (ROS) scavenging systems in living organisms, capable of efficiently catalyzing the decomposition of excess ROS and playing pivotal roles in anti-aging processes and tumor therapy. However, natural enzymes face significant limitations in practical applications, including limited sources, poor stability, and high production costs. The catalytic mechanisms and precisely organized three-dimensional structures of natural antioxidant enzymes provide important biomimetic insights for designing and developing artificial nanozymes. Among these, cerium-based nanozymes exhibit superior antioxidant-like activity and reaction kinetics due to their unique Ce³⁺/Ce⁴⁺ redox pairs and surface oxygen vacancy structures, demonstrating promising application in biomedical fields. This review systematically summarizes the catalytic mechanisms and biomedical applications of cerium-based antioxidant nanozymes. Building upon the biomimetic catalytic principles of natural catalase, we analyze the structure-activity relationships and performance enhancement strategies of cerium-based antioxidant nanozymes. Furthermore, we highlight recent advances in biomedical applications of cerium-based antioxidant nanozymes and discuss current challenges and future opportunities for their future use.

抗氧化酶是生物体内重要的活性氧（ROS）清除系统，能够有效催化多余ROS的分解，在抗衰老和肿瘤治疗中发挥关键作用。然而，天然酶在实际应用中面临着很大的限制，包括来源有限、稳定性差、生产成本高。天然抗氧化酶的催化机制和精确组织的三维结构为设计和开发人工纳米酶提供了重要的仿生见解。其中，铈基纳米酶由于其独特的Ce3+/Ce4+氧化还原对和表面氧空位结构，表现出优异的抗氧化活性和反应动力学，在生物医学领域具有广阔的应用前景。本文系统地综述了铈基抗氧化纳米酶的催化机理及其在生物医学上的应用。基于天然过氧化氢酶的仿生催化原理，分析了铈基抗氧化纳米酶的构效关系和性能增强策略。此外，我们重点介绍了铈基抗氧化纳米酶在生物医学应用方面的最新进展，并讨论了其未来应用的当前挑战和未来机遇。

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引用次数: 0

Combining network pharmacology and computational approaches for screening of apiaceae-derived phytochemicals as inhibitors of DNA polymerase III in streptococcus pyogenes causing streptococcal toxic shock syndrome 结合网络药理学和计算方法筛选引起链球菌中毒性休克综合征的化脓性链球菌DNA聚合酶III抑制剂的apiaceae衍生植物化学物质

IF 1.3 4区化学 Q4 CHEMISTRY, ANALYTICAL

Chinese Journal of Analytical Chemistry

Pub Date : 2025-09-13 DOI: 10.1016/j.cjac.2025.100632

Muhammad NAVEED , Muhammad ASIM , Tariq AZIZ , Mehak AYYAZ , Shumaila IBRAHIM , Muhammad Nouman MAJEED , Ayaz Ali KHAN , Ammena Y. BINSALEH , Nawal AL-HOSHANI , Maher S. ALWETHAYNANI , Fakhria A. AL-JOUFI , Deema FALLATAH

Streptococcus pyogenes (S. pyogenes), a pathogen responsible for various severe infections, including streptococcal toxic shock syndrome (STSS), poses a significant therapeutic challenge worldwide. This study aims to explore the structural and functional properties of the DNA polymerase III subunit beta of S. pyogenes, identify potential phytochemical inhibitors, and evaluate their drug-like properties using computational methods. The DNA polymerase III subunit beta of S. pyogenes was successfully characterized, and its interactions with 60 phytochemicals from the Apiaceae family were predicted. ADMET analysis indicated that several compounds possessed desirable properties, including good solubility and high drug-likeness. Alpha-carotene emerged as a lead candidate exhibiting promising binding affinity and favorable interactions in docking studies. Additionally, to enhance the potency of the target compound, fragment optimization was performed, resulting in the development of a novel lead compound. Toxicity analysis indicated a low risk for adverse effects. Moreover, molecular dynamics simulations revealed that Alpha-carotene and DNA polymerase-III maintained stability with RMSD values below 4.3 Å. RMSF analysis showed significant flexibility in specific regions, reflecting effective interactions and increased stability over time. Overall, this study provides a comprehensive assessment of the DNA polymerase III subunit beta of S. pyogenes and its interactions with potential phytochemical inhibitors. Alpha-carotene, in particular, demonstrates significant potential as a therapeutic agent against S. pyogenes infections. These findings require further experimental validation for the potential development of novel antimicrobial agents against S. pyogenes.

化脓性链球菌（S. pyogenes）是一种导致多种严重感染的病原体，包括链球菌中毒性休克综合征（STSS），在世界范围内构成了重大的治疗挑战。本研究旨在探索化脓性葡萄球菌DNA聚合酶III亚基β的结构和功能特性，鉴定潜在的植物化学抑制剂，并利用计算方法评估其药物样特性。成功地鉴定了化脓链球菌的DNA聚合酶III亚基β，并预测了其与蜂科60种植物化学物质的相互作用。ADMET分析表明，几种化合物具有良好的溶解度和药物相似性。α -胡萝卜素在对接研究中表现出良好的结合亲和力和良好的相互作用。此外，为了提高目标化合物的效力，进行了片段优化，从而开发了一种新的先导化合物。毒性分析显示不良反应风险低。此外，分子动力学模拟显示，α -胡萝卜素和DNA聚合酶- iii保持稳定，RMSD值低于4.3 Å。RMSF分析显示特定区域具有显著的灵活性，反映了有效的相互作用和随时间增加的稳定性。总的来说，本研究提供了化脓性葡萄球菌DNA聚合酶III亚基β及其与潜在植物化学抑制剂的相互作用的全面评估。特别是-胡萝卜素，作为一种治疗化脓性葡萄球菌感染的药物显示出了巨大的潜力。这些发现需要进一步的实验验证，以开发针对化脓性葡萄球菌的新型抗菌药物。

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引用次数: 0

Rational design of MMP-independent fluorescent probe for in vivo visualization of mitochondrial viscosity in fatty liver and cancer models 合理设计不依赖mmp的荧光探针，用于脂肪肝和肿瘤模型线粒体粘度的体内可视化

IF 1.3 4区化学 Q4 CHEMISTRY, ANALYTICAL

Chinese Journal of Analytical Chemistry

Pub Date : 2025-09-11 DOI: 10.1016/j.cjac.2025.100630

Xiaodong WANG , Zonghui LIU , Yinuo YAN , Minglu LI , Hongle AN , Hui WANG , Bingchun XUE

Unraveling the intrinsic correlation between disease and mitochondrial viscosity presents a significant challenge. Traditional mitochondrial viscosity probes, which depend on mitochondrial membrane potential (MMP), within the context of disease-related physiology and pathology, the decline of MMP in response to varying biological conditions can diminish the electrostatic forces binding probes to mitochondria. As a result, these probes are susceptible to diffusing away from the mitochondrial matrix, leading to unreliable detection outcomes and spatiotemporal data. To date, the visualization of abnormal mitochondrial viscosity in clinical samples from cancer patients has not been achieved. To overcome this pressing challenge, we have meticulously synthesized a potent mitochondrial immobilization and viscosity-sensitive fluorescent probe bearing a lengthy alkyl chain (M-KZ-C8). This probe comprises a carbazole moiety serving as an electron donor (D) and an indole group functioning as an electron acceptor (A), thus adopting a classical d-A molecular structure. Utilizing the twisted intramolecular charge transfer, M-KZ-C8 exhibits exceptional sensitivity to viscosity fluctuations. Moreover, we have observed that M-KZ-C8 possesses an impressive capability for precisely monitoring mitochondrial viscosity changes within living cells, unaffected by alterations in MMP. Leveraging M-KZ-C8, we have successfully imaged heightened mitochondrial viscosity in fatty liver and cancerous tissues. Remarkably, the probe has achieved the visualization of mitochondrial viscosity not only at tissue and organ levels but also in surgical specimens from clinical cancer patients for the first time, heralding its vast potential for clinical diagnosis of human cancers. These attributes render M-KZ-C8 an efficacious diagnostic tool for the precise detection, unwavering fidelity, and prolonged imaging of diseases associated with mitochondrial viscosity.

揭示疾病与线粒体黏度之间的内在相关性是一项重大挑战。传统的线粒体粘度探针依赖于线粒体膜电位（MMP），在疾病相关的生理和病理背景下，MMP在不同生物条件下的下降可以减少将探针与线粒体结合的静电力。因此，这些探针容易扩散远离线粒体基质，导致不可靠的检测结果和时空数据。迄今为止，尚未实现癌症患者临床样品中异常线粒体粘度的可视化。为了克服这一紧迫的挑战，我们精心合成了一种具有长烷基链（M-KZ-C8）的强效线粒体固定化和粘度敏感荧光探针。该探针包括咔唑基团作为电子给体(D)和吲哚基团作为电子受体(a)，因此采用经典的D - a分子结构。利用扭曲的分子内电荷转移，M-KZ-C8对粘度波动表现出异常的敏感性。此外，我们观察到M-KZ-C8具有精确监测活细胞内线粒体粘度变化的令人印象深刻的能力，不受MMP改变的影响。利用M-KZ-C8，我们成功成像了脂肪肝和癌组织中线粒体粘度升高。值得注意的是，该探针不仅在组织和器官水平上实现了线粒体粘度的可视化，而且首次在临床癌症患者的手术标本中实现了线粒体粘度的可视化，预示着其在人类癌症临床诊断中的巨大潜力。这些特性使M-KZ-C8成为一种有效的诊断工具，用于精确检测、不动摇的保真度和与线粒体黏度相关的疾病的长时间成像。

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引用次数: 0

A novel electrochemical sensor based on Pickering-droplet-derived Cu-MOF microcapsules for simultaneous determination of dopamine and paracetamol 基于皮克林微滴衍生Cu-MOF微胶囊的新型电化学传感器用于同时测定多巴胺和扑热息痛

IF 1.3 4区化学 Q4 CHEMISTRY, ANALYTICAL

Chinese Journal of Analytical Chemistry

Pub Date : 2025-09-10 DOI: 10.1016/j.cjac.2025.100623

Danping TIAN , Ruipeng HAO , Yanzi ZHANG , Wanyu XIE , Pei ZHANG , Wenbo LU

A novel electrochemical sensing platform was developed based on copper-based metal-organic framework (Cu-MOF) microcapsules synthesized via a Pickering emulsion templating approach, where carbon nanoparticles used as solid emulsifiers to enhance electrode interfacial interactions and material conductivity. This design synergistically combines the superior catalytic activity of Cu-MOF with the conductive carbon matrix. The Cu-MOF microcapsules were applied in the modification of a glassy carbon electrode to obtain an electrochemical sensor for simultaneous detection of dopamine and paracetamol. This sensor showed the good sensing performance with a broad linearity range (2–1600 μM for dopamine and 2–6500 μM for paracetamol) and low detection limits (1.69 μM for dopamine and 1.81 μM for paracetamol at S/N = 3). This platform also demonstrated excellent reproducibility (RSD < 3 %) and selectivity against common interferents, highlighting its potential for practical applications in real sample detection.

基于Pickering乳液模板法合成的铜基金属有机骨架（Cu-MOF）微胶囊，开发了一种新型电化学传感平台，其中碳纳米颗粒作为固体乳化剂增强电极界面相互作用和材料导电性。该设计将Cu-MOF优异的催化活性与导电碳基体协同结合。利用Cu-MOF微胶囊对玻碳电极进行修饰，得到了一种同时检测多巴胺和扑热息痛的电化学传感器。该传感器具有较宽的线性范围（多巴胺为2 ~ 1600 μM，扑热息痛为2 ~ 6500 μM）和较低的检出限（S/N = 3时，多巴胺为1.69 μM，扑热息痛为1.81 μM）。该平台还显示出出色的再现性（RSD < 3%）和对常见干扰的选择性，突出了其在实际样品检测中的实际应用潜力。

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引用次数: 0

Optimized extraction and antioxidant activity of polysaccharides from Inonotus hispidus using three-phase partitioning 三相分馏法优化了柳条多糖的提取及抗氧化活性

IF 1.3 4区化学 Q4 CHEMISTRY, ANALYTICAL

Chinese Journal of Analytical Chemistry

Pub Date : 2025-08-05 DOI: 10.1016/j.cjac.2025.100609

Xiaoshuang ZHOU , Xiaofeng MA , Kai HUANG , Tianyu SHI , Qin TIAN , Tianli ZHANG , Shude YANG , Xianhao CHENG , Rui ZHANG , Yongfei MING

Inonotus hispidus (I. hispidus) is rich in bioactive polysaccharides, making it a valuable dietary supplement and medicinal ingredient. This study employed the three-phase separation method (TPP) to extract and purify polysaccharides from I. hispidus, designated as SH-T. The resulting polysaccharides were then compared with those obtained through the traditional hot water extraction and ethanol precipitation method, designated as SHC, in terms of their physicochemical properties and in vitro antioxidant activity. SH-T extraction achieved maximum efficiency 20 % ammonium sulfate, 1:2 (sample:tert‑butanol) phase ratio, and 25 °C. Under these circumstances, SH-T exhibited a higher protein removal rate, with a yield of 11.10 % and a polysaccharide content of 60.84 %, nearly twice that of SHC obtained through the WEAP method. SH-T and SHC exhibited similar structural characteristics. SH-T displayed superior performance in scavenging DPPH^–, ABTS⁺, and •OH while exhibiting higher reducing power than SHC. In conclusion, TPP demonstrated efficacy in extracting polysaccharides from I. hispidus, yielding products of high purity and enhanced antioxidant properties, thus presenting a promising methodology for the isolation of polysaccharides from I. hispidus.

牛皮草（Inonotus hispidus）富含生物活性多糖，是一种有价值的膳食补充剂和药用成分。本研究采用三相分离法（TPP）对海鞘多糖进行提取纯化，命名为SH-T。然后将所得多糖与传统热水提取和乙醇沉淀法所得的多糖（称为SHC）进行理化性质和体外抗氧化活性比较。SH-T萃取的最大效率为20% %硫酸铵，1:2（样品：叔丁醇）相比，温度为25°C。在此条件下，SH-T的蛋白质去除率更高，产率为11.10 %，多糖含量为60.84 %，几乎是WEAP法的两倍。SH-T和SHC表现出相似的结构特征。SH-T对DPPH -、ABTS+和•OH的清除能力优于SHC，还原能力优于SHC。综上所述，TPP有效地提取了海鞘多糖，所得产物纯度高，抗氧化性能增强，为海鞘多糖的分离提供了一种很有前景的方法。

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引用次数: 0

Multi-omics integration of LC-MS/MS, network pharmacology, and molecular docking reveals pleiotropic mechanisms of Millettia speciosa Champ. in NAFLD therapy LC-MS/MS、网络药理学、分子对接等多组学整合研究揭示了密菇的多效机制。NAFLD治疗

IF 1.3 4区化学 Q4 CHEMISTRY, ANALYTICAL

Chinese Journal of Analytical Chemistry

Pub Date : 2025-07-22 DOI: 10.1016/j.cjac.2025.100600

Zhuo-Fan XIE, Hao-liang ZHANG, Zao-liang MA, Su-Fang CHEN, Jian-Chun MA

Non-alcoholic fatty liver disease (NAFLD), the most prevalent chronic liver disorder worldwide, is characterized by excessive triglyceride accumulation in the liver. It is strongly associated with metabolic syndrome, type 2 diabetes mellitus, obesity, and cardiovascular diseases. Fueled by the global increase in obesity rates, NAFLD has emerged as the most common liver disease globally. In this study, we utilized liquid chromatography-tandem mass spectrometry (LC-MS/MS) to comprehensively characterize the chemical constituents of Millettia speciosa Champ. By combining network pharmacology and molecular docking techniques, we constructed a “component-target-pathway” network to elucidate the therapeutic targets and mechanisms underlying the anti-NAFLD effects of Millettia speciosa Champ. This integrated approach offers novel insights into its pharmacological activity and identifies potential clinical applications for NAFLD management.

非酒精性脂肪性肝病（NAFLD）是世界范围内最常见的慢性肝病，其特征是肝脏中甘油三酯积累过多。它与代谢综合征、2型糖尿病、肥胖和心血管疾病密切相关。在全球肥胖率上升的推动下，NAFLD已成为全球最常见的肝脏疾病。本研究采用液相色谱-串联质谱（LC-MS/MS）技术对密菇的化学成分进行了全面表征。通过网络药理学和分子对接技术相结合，构建了“组分-靶点-通路”网络，阐明了粟特抗nafld的治疗靶点和作用机制。这种综合方法为其药理活性提供了新的见解，并确定了NAFLD治疗的潜在临床应用。

引用次数: 0

In situ produced palladium nanoparticle-catalyzed efficient synthesis of benzo[c]chromenes and analogues under aerobic and ligand-free conditions in water 在好氧和无配体条件下，原位制备钯纳米颗粒催化苯并[c]铬及其类似物的高效合成

IF 1.3 4区化学 Q4 CHEMISTRY, ANALYTICAL

Chinese Journal of Analytical Chemistry

Pub Date : 2025-07-14 DOI: 10.1016/j.cjac.2025.100589

Pompy Sarkar , Jayanta K. Ray , Atiur Ahmed

An efficient approach has been discovered towards the preparation of 6H-benzo[c]chromenes and analogues via the in situ developed palladium nanoparticle-catalyzed cascade of Suzuki-Miyaura cross-coupling and intramolecular S_N2 reaction under aerobic conditions. To make the reactions eco-friendly, water was chosen as the solvent along with the use of phosphine ligand was avoided. The reactions were found to be highly efficient with the productions of the chromenes upto the excellent yield of 96 % at 80 °C. Therefore, the several advantages like eco-friendly, mild, easy to handle, tolerance of various functional groups and efficient production of diverse benzo[c]chromenes have made this method as novel.

在好氧条件下，原位开发的钯纳米颗粒催化的Suzuki-Miyaura交叉偶联级联反应和分子内SN2反应是制备6h -苯并[c]铬及其类似物的有效途径。为了使反应生态友好，选择水作为溶剂，避免了使用膦配体。结果表明，该反应在80°C条件下的产率可达96%。因此，该方法具有环保、温和、易操作、对多种官能团的耐受性以及能高效生产多种苯并[c]铬等优点，是一种新颖的方法。

引用次数: 0