Chinese Journal of Analytical Chemistry最新文献_第4页

Evaluation of geochemical composition and heavy metals related occupational health risks of Ambo sandstone quarry sites, West Shewa of Ethiopia 埃塞俄比亚西谢瓦Ambo砂岩采石场地球化学成分及重金属相关职业健康风险评价

IF 1.3 4区化学 Q4 CHEMISTRY, ANALYTICAL

Chinese Journal of Analytical Chemistry

Pub Date : 2025-09-11 DOI: 10.1016/j.cjac.2025.100628

Chala Mellese , Birhanu Mekassa , Lemessa B. Merga , Bayissa Leta Danno

Prolonged exposure to sandstone dust from quarry sites has been associated with adverse health hazards. This study was aimed to evaluate the geochemistry (major oxides and trace heavy metal(loid)s) of Ambo sandstone, and human health risks of heavy metals due to exposure to the sandstone dust from main quarry sites of West Shewa, Ethiopia. Lithium metaborate fusion-FAAS and wet acid digestion-ICP-OES were used for major oxides and heavy metal(loid)s determination, respectively. The mean concentration of major oxides in the sandstones was in decreasing order of: SiO₂ > Al₂O₃ > Na₂O > Fe₂O₃ > K₂O > CaO > MgO > MnO. Geochemical results of Ambo sandstones indicated that they are mineralogically immature and classified into Greywacke. The mean levels of heavy metal(loid)s in Ambo sandstone were ranged 10.37‒28.20, 9.37‒19.07, 1.71‒8.15, 12.20‒15.28, 5.89‒15.38 and 100.35‒138.92 in mg/kg for Pb, Zn, Cd, Cu, Ni and Cr, respectively. Hazard quotient and hazard index were < 1, signifying no non-carcinogenic health risks due to exposure to Ambo sandstone dusts. The cancer risk values for the individual metal(loid)s (Cd, Ni, Cr, Pb and As) is within the tolerable range or insignificant (ILCR

\leq

1.0 × 10^–4). However, total cancer risks resulting from exposure to multiple elements exceeded the acceptable threshold value of cancer risk (2.1 × 10^–4 (Senkelle) and 1.05 × 10^–4 (Aleltu)), demonstrating possible carcinogenic risk to the exposed workforces. Carcinogenic risk result revealed that Cr contributed the most significant risk with ingestion route as the primary exposure pathway. The finding signifies the requirement of strict regulatory control by all stakeholders to mitigate the carcinogenic health risks. It also highlights the need for awareness creation of the potential dangers due to prolonged exposure to the sandstone dust. Continuous surveillance and research on metal(loid)s accumulation in sandstone dust, agricultural soil and vegetables near quarry sites are vital to safeguard public health.

长期接触来自采石场的砂岩粉尘与不利的健康危害有关。本研究旨在评价Ambo砂岩的地球化学（主要氧化物和微量重金属），以及暴露于埃塞俄比亚西谢瓦主要采石场砂岩粉尘中重金属的人体健康风险。主要氧化物和重金属的测定分别采用偏酸锂熔合-火焰原子吸收光谱法和湿酸消化- icp - oes法。砂岩中主要氧化物的平均浓度依次为：SiO2 >； Al2O3 > Na2O > Fe2O3 > K2O > CaO > MgO > MnO。安博砂岩的地球化学结果表明其矿物学上不成熟，属于格雷瓦克类。Ambo砂岩中Pb、Zn、Cd、Cu、Ni和Cr的平均mg/kg含量分别为10.37 ~ 28.20、9.37 ~ 19.07、1.71 ~ 8.15、12.20 ~ 15.28、5.89 ~ 15.38和100.35 ~ 138.92。危害商数和危害指数均为1，表明安博砂岩粉尘不存在非致癌性健康风险。单个金属（样态）s （Cd、Ni、Cr、Pb和As）的致癌风险值在可容忍范围内或不显著（ILCR≤1.0 × 10-4）。然而，暴露于多种元素导致的总癌症风险超过了可接受的癌症风险阈值（2.1 × 10-4 （Senkelle）和1.05 × 10-4 (Aleltu)），表明暴露的工作人员可能存在致癌风险。致癌风险结果显示，以摄入途径为主要暴露途径的Cr对致癌风险贡献最大。这一发现表明，所有利益相关者都需要严格的监管控制，以减轻致癌的健康风险。它还强调需要提高人们对长期暴露在砂岩粉尘中的潜在危险的认识。对砂石粉尘、农业土壤和采石场附近蔬菜中金属（样物质）的积累进行持续监测和研究，对保障公众健康至关重要。

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引用次数: 0

Astragaloside IV alleviates metabolic associated fatty liver disease by regulating ferroptosis via the SLC7A11/GPX4 pathway 黄芪甲苷通过SLC7A11/GPX4通路调节铁下垂，减轻代谢性脂肪肝疾病

IF 1.3 4区化学 Q4 CHEMISTRY, ANALYTICAL

Chinese Journal of Analytical Chemistry

Pub Date : 2025-09-11 DOI: 10.1016/j.cjac.2025.100625

Sitong CHEN , Hanying XU , Zipei ZHANG , Xiaonan LI , Xiaolei TANG , Dashi YING

Metabolic associated fatty liver disease (MAFLD), characterized by hepatic steatosis and metabolic dysregulation, is the most prevalent chronic liver disease worldwide, yet effective therapeutic strategies remain limited due to its complex pathogenesis. Astragaloside IV (AST IV), a bioactive saponin derived from Astragalus membranaceus, has demonstrated hypoglycemic, lipid-modulating, antioxidative, and hepatoprotective properties—though its specific mechanisms against MAFLD are not fully elucidated. In this study, we established high-fat diet-induced mouse and free fatty acid-induced HepG2 cell models of MAFLD to evaluate the efficacy of AST IV. Serum biochemical analyses revealed that AST IV significantly improved glucolipid metabolism and reduced hepatic injury. Combining network pharmacology prediction with experimental validation, we identified ferroptosis as a key pathway targeted by AST IV. Specifically, AST IV upregulates SLC7A11 and GPX4 expression while downregulating ACSL4, thereby inhibiting ferroptosis. Molecular docking further confirmed strong binding affinities between AST IV and these core proteins. In conclusion, our findings demonstrate that AST IV alleviates MAFLD by suppressing ferroptosis, highlighting its potential as a novel phytochemical candidate for MAFLD intervention.

代谢性脂肪性肝病（MAFLD）以肝脏脂肪变性和代谢失调为特征，是世界范围内最常见的慢性肝病，但由于其复杂的发病机制，有效的治疗策略仍然有限。黄芪甲苷（Astragaloside IV, AST IV）是一种从黄芪中提取的生物活性皂苷，具有降血糖、调节血脂、抗氧化和保护肝脏的特性，但其抗mald的具体机制尚未完全阐明。本研究通过建立高脂饮食诱导小鼠和游离脂肪酸诱导的MAFLD HepG2细胞模型来评价AST IV的疗效。血清生化分析显示，AST IV可显著改善糖脂代谢，减轻肝损伤。结合网络药理学预测和实验验证，我们确定了AST IV靶向铁下垂的关键途径。具体而言，AST IV上调SLC7A11和GPX4的表达，下调ACSL4，从而抑制铁下垂。分子对接进一步证实了AST IV与这些核心蛋白之间的强结合亲和力。总之，我们的研究结果表明，AST IV通过抑制铁下垂来减轻MAFLD，突出了其作为一种新的植物化学候选物干预MAFLD的潜力。

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引用次数: 0

Rational design of MMP-independent fluorescent probe for in vivo visualization of mitochondrial viscosity in fatty liver and cancer models 合理设计不依赖mmp的荧光探针，用于脂肪肝和肿瘤模型线粒体粘度的体内可视化

IF 1.3 4区化学 Q4 CHEMISTRY, ANALYTICAL

Chinese Journal of Analytical Chemistry

Pub Date : 2025-09-11 DOI: 10.1016/j.cjac.2025.100630

Xiaodong WANG , Zonghui LIU , Yinuo YAN , Minglu LI , Hongle AN , Hui WANG , Bingchun XUE

Unraveling the intrinsic correlation between disease and mitochondrial viscosity presents a significant challenge. Traditional mitochondrial viscosity probes, which depend on mitochondrial membrane potential (MMP), within the context of disease-related physiology and pathology, the decline of MMP in response to varying biological conditions can diminish the electrostatic forces binding probes to mitochondria. As a result, these probes are susceptible to diffusing away from the mitochondrial matrix, leading to unreliable detection outcomes and spatiotemporal data. To date, the visualization of abnormal mitochondrial viscosity in clinical samples from cancer patients has not been achieved. To overcome this pressing challenge, we have meticulously synthesized a potent mitochondrial immobilization and viscosity-sensitive fluorescent probe bearing a lengthy alkyl chain (M-KZ-C8). This probe comprises a carbazole moiety serving as an electron donor (D) and an indole group functioning as an electron acceptor (A), thus adopting a classical d-A molecular structure. Utilizing the twisted intramolecular charge transfer, M-KZ-C8 exhibits exceptional sensitivity to viscosity fluctuations. Moreover, we have observed that M-KZ-C8 possesses an impressive capability for precisely monitoring mitochondrial viscosity changes within living cells, unaffected by alterations in MMP. Leveraging M-KZ-C8, we have successfully imaged heightened mitochondrial viscosity in fatty liver and cancerous tissues. Remarkably, the probe has achieved the visualization of mitochondrial viscosity not only at tissue and organ levels but also in surgical specimens from clinical cancer patients for the first time, heralding its vast potential for clinical diagnosis of human cancers. These attributes render M-KZ-C8 an efficacious diagnostic tool for the precise detection, unwavering fidelity, and prolonged imaging of diseases associated with mitochondrial viscosity.

揭示疾病与线粒体黏度之间的内在相关性是一项重大挑战。传统的线粒体粘度探针依赖于线粒体膜电位（MMP），在疾病相关的生理和病理背景下，MMP在不同生物条件下的下降可以减少将探针与线粒体结合的静电力。因此，这些探针容易扩散远离线粒体基质，导致不可靠的检测结果和时空数据。迄今为止，尚未实现癌症患者临床样品中异常线粒体粘度的可视化。为了克服这一紧迫的挑战，我们精心合成了一种具有长烷基链（M-KZ-C8）的强效线粒体固定化和粘度敏感荧光探针。该探针包括咔唑基团作为电子给体(D)和吲哚基团作为电子受体(a)，因此采用经典的D - a分子结构。利用扭曲的分子内电荷转移，M-KZ-C8对粘度波动表现出异常的敏感性。此外，我们观察到M-KZ-C8具有精确监测活细胞内线粒体粘度变化的令人印象深刻的能力，不受MMP改变的影响。利用M-KZ-C8，我们成功成像了脂肪肝和癌组织中线粒体粘度升高。值得注意的是，该探针不仅在组织和器官水平上实现了线粒体粘度的可视化，而且首次在临床癌症患者的手术标本中实现了线粒体粘度的可视化，预示着其在人类癌症临床诊断中的巨大潜力。这些特性使M-KZ-C8成为一种有效的诊断工具，用于精确检测、不动摇的保真度和与线粒体黏度相关的疾病的长时间成像。

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引用次数: 0

A review of g-C3N4-based photocatalysts for antibiotic elimination: Mechanistic insights and operational parameters 基于g- c3n4的抗生素消除光催化剂综述：机理和操作参数

IF 1.3 4区化学 Q4 CHEMISTRY, ANALYTICAL

Chinese Journal of Analytical Chemistry

Pub Date : 2025-09-11 DOI: 10.1016/j.cjac.2025.100626

Ibrahima BINETA, Otieno KIRMANI

The global rise of antibiotic resistance has intensified interest in advanced photocatalytic materials for removing antibiotic pollutants from water systems. Graphitic carbon nitride (g-C₃N₄), a metal-free polymeric semiconductor, has emerged as a sustainable and efficient photocatalyst owing to its visible-light activity, chemical stability, and tunable electronic properties. This review summarizes recent progress in g-C₃N₄-based photocatalysts designed for antibiotic photodegradation, with emphasis on structural modifications, doping strategies, and heterojunction architectures that enhance photocatalytic performance. The underlying mechanisms of photodegradation, including reactive oxygen species generation and charge transfer dynamics, are discussed in detail. Furthermore, we examine the key factors governing photocatalytic efficiency, such as temperature, types of active species, solution pH, catalyst dosage, antibiotic concentration, coexisting anions, and the nature of dopants. Finally, the challenges and future perspectives for practical applications of g-C₃N₄ in wastewater treatment are highlighted.

抗生素耐药性的全球上升已经加强了对先进的光催化材料去除水系统中的抗生素污染物的兴趣。石墨氮化碳（g-C₃N₄）是一种无金属聚合物半导体，由于其可见光活性、化学稳定性和可调谐的电子特性，已经成为一种可持续和高效的光催化剂。本文综述了用于抗生素光降解的g-C₃N₄基光催化剂的最新进展，重点介绍了结构修饰、掺杂策略和提高光催化性能的异质结结构。详细讨论了光降解的基本机制，包括活性氧的产生和电荷转移动力学。此外，我们研究了控制光催化效率的关键因素，如温度、活性物质类型、溶液pH、催化剂用量、抗生素浓度、共存阴离子和掺杂剂的性质。最后，重点介绍了g-C₃N₄在废水处理中的实际应用所面临的挑战和未来前景。

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引用次数: 0

A novel electrochemical sensor based on Pickering-droplet-derived Cu-MOF microcapsules for simultaneous determination of dopamine and paracetamol 基于皮克林微滴衍生Cu-MOF微胶囊的新型电化学传感器用于同时测定多巴胺和扑热息痛

IF 1.3 4区化学 Q4 CHEMISTRY, ANALYTICAL

Chinese Journal of Analytical Chemistry

Pub Date : 2025-09-10 DOI: 10.1016/j.cjac.2025.100623

Danping TIAN , Ruipeng HAO , Yanzi ZHANG , Wanyu XIE , Pei ZHANG , Wenbo LU

A novel electrochemical sensing platform was developed based on copper-based metal-organic framework (Cu-MOF) microcapsules synthesized via a Pickering emulsion templating approach, where carbon nanoparticles used as solid emulsifiers to enhance electrode interfacial interactions and material conductivity. This design synergistically combines the superior catalytic activity of Cu-MOF with the conductive carbon matrix. The Cu-MOF microcapsules were applied in the modification of a glassy carbon electrode to obtain an electrochemical sensor for simultaneous detection of dopamine and paracetamol. This sensor showed the good sensing performance with a broad linearity range (2–1600 μM for dopamine and 2–6500 μM for paracetamol) and low detection limits (1.69 μM for dopamine and 1.81 μM for paracetamol at S/N = 3). This platform also demonstrated excellent reproducibility (RSD < 3 %) and selectivity against common interferents, highlighting its potential for practical applications in real sample detection.

基于Pickering乳液模板法合成的铜基金属有机骨架（Cu-MOF）微胶囊，开发了一种新型电化学传感平台，其中碳纳米颗粒作为固体乳化剂增强电极界面相互作用和材料导电性。该设计将Cu-MOF优异的催化活性与导电碳基体协同结合。利用Cu-MOF微胶囊对玻碳电极进行修饰，得到了一种同时检测多巴胺和扑热息痛的电化学传感器。该传感器具有较宽的线性范围（多巴胺为2 ~ 1600 μM，扑热息痛为2 ~ 6500 μM）和较低的检出限（S/N = 3时，多巴胺为1.69 μM，扑热息痛为1.81 μM）。该平台还显示出出色的再现性（RSD < 3%）和对常见干扰的选择性，突出了其在实际样品检测中的实际应用潜力。

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引用次数: 0

Serum metabolomics study on treatment effects of ulcerative colitis of Hudichangrong capsule (HDCRC) in DSS-induced mice 琥肠荣胶囊治疗dss诱导小鼠溃疡性结肠炎的血清代谢组学研究

IF 1.3 4区化学 Q4 CHEMISTRY, ANALYTICAL

Chinese Journal of Analytical Chemistry

Pub Date : 2025-09-01 DOI: 10.1016/j.cjac.2025.100621

Jingjing LIU , Wenbin SUN , Shusen LIU , Xiaoyu HAN , Hanxue ZHAO , Xinyu MA , Beilei XU , Jing LIU

Objectives

Hudichangrong capsule (HDCRC) is a clinical commonly used formula with obvious curative effects on ulcerative colitis (UC), but its endogenous metabolic mechanism about UC intervention remains largely unknown so far.

Methods

To study the difference of serum metabolism between HDCRC group and UC group, the UC mice model was induced by DSS, and DAI score, weight and pathological degree of intestinal inflammation were used to assess the effect of HDCRC, of which the serum chemical components were characterized in advance. Then serum untargeted metabolomics based on ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS/MS) was established to collect the metabolic profiles of mice and explore the metabolic changes that occurred after HDCRC treatment, followed by principal component analysis (PCA) and orthogonal projection to latent structures squares-discriminant analysis (OPLS-DA).

Results

The PCA model revealed significant differences among the animal groups, and OPLS-DA identified HDCRC-induced changes of 38 potential biomarkers mainly involved in amino acid metabolism, including phenylalanine, tyrosine and tryptophan biosynthesis, and alanine, aspartate and glutamate metabolism. The results implied that endogenous metabolic processes might play a vital role in the treatment progress of UC by HDCRC. Our study also demonstrates that 73 chemical constituents of serum such as emodin, emodin-1-O-glucoside, galloyl-piceid, liquiritigenin and liquiritin with potential treatment effects activity on UC, which exert their therapeutic effects by multiple mechanisms and might be related to their endogenous metabolism.

Conclusion

We identified amino acid metabolites associated with UC therapy by HDCRC.

目的聚肠荣胶囊（HDCRC）是治疗溃疡性结肠炎（UC）的临床常用方剂，疗效明显，但其干预UC的内源性代谢机制至今仍不甚清楚。方法为了研究HDCRC组与UC组血清代谢的差异，采用DSS诱导UC小鼠模型，采用DAI评分、体重和肠道炎症病理程度评价HDCRC的作用，并对其血清化学成分进行预先表征。然后建立基于超高效液相色谱-四极杆飞行时间质谱（UPLC-QTOF-MS/MS）的血清非靶向代谢组学，收集小鼠的代谢谱，探讨HDCRC治疗后小鼠的代谢变化，然后进行主成分分析（PCA）和正交投影到潜在结构平方-鉴别分析（OPLS-DA）。结果PCA模型显示各组动物之间存在显著差异，OPLS-DA鉴定出hdcrc诱导的38种主要参与氨基酸代谢的潜在生物标志物的变化，包括苯丙氨酸、酪氨酸和色氨酸的生物合成，以及丙氨酸、天冬氨酸和谷氨酸的代谢。结果表明，内源性代谢过程可能在HDCRC治疗UC的过程中起重要作用。我们的研究还发现，血清中大黄素、大黄素-1- o -葡萄糖苷、没食子酰吡啶、利尿素、利尿素等73种化学成分对UC具有潜在的治疗作用活性，其作用机制多种多样，可能与其内源性代谢有关。结论我们发现了与HDCRC治疗UC相关的氨基酸代谢物。

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引用次数: 0

Synthesis, characterization, and evaluation of the antioxidant and anticancer activities of metal ion complexes with a novel 7-(3-hydroxyphenylazo)-quinolin-8-ol ligand 新型7-（3-羟基苯基偶氮）-喹啉-8-醇金属离子配合物的合成、表征及抗氧化抗癌活性评价

IF 1.3 4区化学 Q4 CHEMISTRY, ANALYTICAL

Chinese Journal of Analytical Chemistry

Pub Date : 2025-09-01 DOI: 10.1016/j.cjac.2025.100617

Noor T.A. AL-RUBAYE , Susan Duraid AHMED , Abbas Ali Salih AL-HAMDANI , Lubna ALHAMOUD , Wail AL  ZOUBI

A novel azo dye was prepared by reacting the diazonium salt of 3-aminophenol with 8-hydroxyquinoline and subsequently used to prepare a series of Ni⁺², Pd⁺², Pt⁺⁴, and Cu⁺² complexes. The ligand structure was characterized via¹H-and ¹³C-nuclear magnetic resonance spectroscopy. The as-synthesized materials were characterized via Fourier-transform infrared, ultraviolet‒visible, and mass spectroscopy, as well as thermo gravimetry, differential scanning calorimetry, and elemental analysis. Conductivity, magnetic susceptibility, and the metal and chloride contents of the complexes were also determined. The ligand exhibited a trigonal geometry, whereas the Cu⁺², Pd⁺², Pt⁺⁴, and Ni⁺² complexesexhibited tetrahedral, square planar, octahedral, and tetrahedral geometries, respectively. The complexes contained water within the coordination field and all of them were non-electrolytes. The effectiveness of the ligand and metal complexes in inhibiting free radicals was evaluated by analyzing their antioxidant activities using 2,2-diphenyl-1-picrylhydrazyl as the free radical and gallic acid as the standard. The ligand exhibited a higher ability to inhibit free radicals than the complexes based their IC₅₀ values. The free radical scavenging ability was in the order of: (H₂L > gallic acid > Cu⁺² > Ni⁺² > Pt⁺⁴ complex. The Pt⁺⁴ and Cu⁺² complexes were evaluated as anticancer agents against theMCF-7cells using different concentrations (7.4, 22.22, 66.66, 200, and 600 µg/mL). The Pt⁺⁴ complex exhibited a lower IC₅₀ value (147.61 µg/mL) than the Cu(II) complex(152.91 µg/mL), indicating its higher inhibition ability.

以3-氨基酚重氮盐与8-羟基喹啉反应制备了一种新型偶氮染料，并用于制备一系列Ni+2、Pd+2、Pt+4和Cu+2配合物。通过核磁共振波谱对配体结构进行了表征。通过傅里叶变换红外、紫外可见、质谱、热重、差示扫描量热和元素分析对合成的材料进行了表征。测定了配合物的电导率、磁化率、金属和氯化物含量。配体为三角形，而Cu+2、Pd+2、Pt+4和Ni+2配合物分别为四面体、方形平面、八面体和四面体。配合物在配位场内均含水，均为非电解质。以2,2-二苯基-1-苦基酰肼为自由基，没食子酸为标准，分析其抗氧化活性，评价配体和金属配合物对自由基的抑制作用。基于IC50值，配体表现出比配合物更高的抑制自由基的能力。对自由基的清除能力排序为：H2L >；没食子酸>； Cu+2 > Ni+2 >； Pt+4配合物。Pt+4和Cu+2配合物在不同浓度（7.4、22.22、66.66、200和600µg/mL）下对themcf -7细胞具有抗癌作用。Pt+4配合物的IC50值（147.61µg/mL）低于Cu（II）配合物（152.91µg/mL），表明其具有较高的抑制能力。

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引用次数: 0

Recent advances in ZnO/MOFs: Synthesis, characterization, and applications in sustainable antibiotic wastewater treatment ZnO/ mof的合成、表征及其在抗生素废水可持续处理中的应用

IF 1.3 4区化学 Q4 CHEMISTRY, ANALYTICAL

Chinese Journal of Analytical Chemistry

Pub Date : 2025-08-31 DOI: 10.1016/j.cjac.2025.100619

Roushree RR, Rijah HAIMBODI

The increasing prevalence of antibiotic pollutants, such as amoxicillin, tetracycline, ciprofloxacin, and sulfamethoxazole, in wastewater poses significant environmental and health risks, including the promotion of antibiotic resistance. This review consolidates recent progress in the synthesis, characterization, and application of zinc oxide (ZnO)/metal-organic framework (MOF) composites as highly efficient photocatalysts and adsorbents for sustainable antibiotic wastewater treatment. ZnO/MOF hybrids achieve degradation efficiencies often exceeding 90 % under optimized conditions, driven by synergistic adsorption (via π-π interactions, electrostatic forces, and pore confinement) and photocatalysis (via reactive oxygen species like •OH and •O₂⁻). Synthesis methods, including in-situ growth, solvothermal, and microwave-assisted techniques, enable tailored composite structures, while advanced characterization (X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Brunauer-Emmett-Teller (BET), Fourier-transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), UV-Vis/NIR) elucidates their structural and chemical synergies. Compared to TiO₂, g-C₃N₄, and graphene-based materials, ZnO/MOFs offer superior tunability and efficiency but face challenges in visible light absorption, aqueous stability, and scalability. These composites demonstrate significant potential for cost-effective, eco-friendly wastewater treatment, reducing antibiotic residues and mitigating resistance proliferation. Future research should focus on enhancing visible light activity, green synthesis, and real-world testing to ensure scalability and environmental safety, positioning ZnO/MOFs as a sustainable solution for global water purification challenges.

废水中阿莫西林、四环素、环丙沙星和磺胺甲恶唑等抗生素污染物的日益普遍，构成了重大的环境和健康风险，包括促进抗生素耐药性。本文综述了氧化锌/金属有机骨架（MOF）复合材料作为高效光催化剂和吸附剂在抗生素废水可持续处理中的应用研究进展。在优化条件下，ZnO/MOF杂化物的降解效率通常超过90%，这是由协同吸附（通过π-π相互作用，静电力和孔限制）和光催化（通过活性氧如•OH和•O₂⁻）所驱动的。合成方法，包括原位生长，溶剂热和微波辅助技术，可以定制复合结构，而先进的表征（x射线衍射（XRD），扫描电子显微镜（SEM），透射电子显微镜（TEM），布鲁诺尔-埃米特-泰勒（BET），傅里叶变换红外光谱（FT-IR）， x射线光电子能谱（XPS）， UV-Vis/NIR）阐明了它们的结构和化学协同作用。与TiO₂、g-C₃N₄和石墨烯基材料相比，ZnO/ mof具有优越的可调性和效率，但在可见光吸收、水稳定性和可扩展性方面面临挑战。这些复合材料在具有成本效益、环保的废水处理、减少抗生素残留和减轻耐药性扩散方面显示出巨大的潜力。未来的研究应侧重于增强可见光活性、绿色合成和实际测试，以确保可扩展性和环境安全性，将ZnO/ mof定位为应对全球水净化挑战的可持续解决方案。

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引用次数: 0

Optimized extraction and antioxidant activity of polysaccharides from Inonotus hispidus using three-phase partitioning 三相分馏法优化了柳条多糖的提取及抗氧化活性

IF 1.3 4区化学 Q4 CHEMISTRY, ANALYTICAL

Chinese Journal of Analytical Chemistry

Pub Date : 2025-08-05 DOI: 10.1016/j.cjac.2025.100609

Xiaoshuang ZHOU , Xiaofeng MA , Kai HUANG , Tianyu SHI , Qin TIAN , Tianli ZHANG , Shude YANG , Xianhao CHENG , Rui ZHANG , Yongfei MING

Inonotus hispidus (I. hispidus) is rich in bioactive polysaccharides, making it a valuable dietary supplement and medicinal ingredient. This study employed the three-phase separation method (TPP) to extract and purify polysaccharides from I. hispidus, designated as SH-T. The resulting polysaccharides were then compared with those obtained through the traditional hot water extraction and ethanol precipitation method, designated as SHC, in terms of their physicochemical properties and in vitro antioxidant activity. SH-T extraction achieved maximum efficiency 20 % ammonium sulfate, 1:2 (sample:tert‑butanol) phase ratio, and 25 °C. Under these circumstances, SH-T exhibited a higher protein removal rate, with a yield of 11.10 % and a polysaccharide content of 60.84 %, nearly twice that of SHC obtained through the WEAP method. SH-T and SHC exhibited similar structural characteristics. SH-T displayed superior performance in scavenging DPPH^–, ABTS⁺, and •OH while exhibiting higher reducing power than SHC. In conclusion, TPP demonstrated efficacy in extracting polysaccharides from I. hispidus, yielding products of high purity and enhanced antioxidant properties, thus presenting a promising methodology for the isolation of polysaccharides from I. hispidus.

牛皮草（Inonotus hispidus）富含生物活性多糖，是一种有价值的膳食补充剂和药用成分。本研究采用三相分离法（TPP）对海鞘多糖进行提取纯化，命名为SH-T。然后将所得多糖与传统热水提取和乙醇沉淀法所得的多糖（称为SHC）进行理化性质和体外抗氧化活性比较。SH-T萃取的最大效率为20% %硫酸铵，1:2（样品：叔丁醇）相比，温度为25°C。在此条件下，SH-T的蛋白质去除率更高，产率为11.10 %，多糖含量为60.84 %，几乎是WEAP法的两倍。SH-T和SHC表现出相似的结构特征。SH-T对DPPH -、ABTS+和•OH的清除能力优于SHC，还原能力优于SHC。综上所述，TPP有效地提取了海鞘多糖，所得产物纯度高，抗氧化性能增强，为海鞘多糖的分离提供了一种很有前景的方法。

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Multi-omics integration of LC-MS/MS, network pharmacology, and molecular docking reveals pleiotropic mechanisms of Millettia speciosa Champ. in NAFLD therapy LC-MS/MS、网络药理学、分子对接等多组学整合研究揭示了密菇的多效机制。NAFLD治疗

IF 1.3 4区化学 Q4 CHEMISTRY, ANALYTICAL

Chinese Journal of Analytical Chemistry

Pub Date : 2025-07-22 DOI: 10.1016/j.cjac.2025.100600

Zhuo-Fan XIE, Hao-liang ZHANG, Zao-liang MA, Su-Fang CHEN, Jian-Chun MA

Non-alcoholic fatty liver disease (NAFLD), the most prevalent chronic liver disorder worldwide, is characterized by excessive triglyceride accumulation in the liver. It is strongly associated with metabolic syndrome, type 2 diabetes mellitus, obesity, and cardiovascular diseases. Fueled by the global increase in obesity rates, NAFLD has emerged as the most common liver disease globally. In this study, we utilized liquid chromatography-tandem mass spectrometry (LC-MS/MS) to comprehensively characterize the chemical constituents of Millettia speciosa Champ. By combining network pharmacology and molecular docking techniques, we constructed a “component-target-pathway” network to elucidate the therapeutic targets and mechanisms underlying the anti-NAFLD effects of Millettia speciosa Champ. This integrated approach offers novel insights into its pharmacological activity and identifies potential clinical applications for NAFLD management.

非酒精性脂肪性肝病（NAFLD）是世界范围内最常见的慢性肝病，其特征是肝脏中甘油三酯积累过多。它与代谢综合征、2型糖尿病、肥胖和心血管疾病密切相关。在全球肥胖率上升的推动下，NAFLD已成为全球最常见的肝脏疾病。本研究采用液相色谱-串联质谱（LC-MS/MS）技术对密菇的化学成分进行了全面表征。通过网络药理学和分子对接技术相结合，构建了“组分-靶点-通路”网络，阐明了粟特抗nafld的治疗靶点和作用机制。这种综合方法为其药理活性提供了新的见解，并确定了NAFLD治疗的潜在临床应用。

引用次数: 0