Coordination Chemistry Reviews最新文献_第7页

Micro- and nanorobots for intelligent bone tissue engineering 用于智能骨组织工程的微纳米机器人

IF 23.5 1区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Coordination Chemistry Reviews

Pub Date : 2026-01-17 DOI: 10.1016/j.ccr.2026.217593

Zelin Ai , Yan Wei , Jiatao Zhang , Jinhua Li

The repair of bone defects presents a significant challenge in balancing material properties with biocompatibility. While traditional materials such as alloys are widely used, they still exhibit limitations in mechanical adaptability, osseointegration capacity, and imaging interference. In recent years, the integration of biodegradable materials and 3D printing technology has provided novel approaches for personalized bone repair, however, the implantation of these scaffolds often requires open surgery, which causes pain for patients, increases the risk of infection, and prolongs healing time. In this context, the micro- and nanorobots (MNRs) can offer groundbreaking opportunities for precision bone tissue engineering in a minimally invasive or even non-invasive manner owing to their unique advantages such as tiny size, precise delivery, and dynamic modulation capabilities. This article focuses on the application potential of MNRs in bone repair, systematically examining their design prerequisites: achieving targeted movement within the tubular structures (such as blood vessels and lymph vessels), cavity structures (such as marrow cavity and articular cavity), and defect space (such as fractures and osteoporosis) in the bone tissue, and analyzing their material selection, propulsion mechanisms, and real-time monitoring strategies. Furthermore, we review recent advances in MNRs-assisted bone defect regeneration, bone infection control, and bone tumor therapy, highlighting their advantages in modulating the local bone microenvironment through the delivery of growth factors, stem cells, or therapeutic agents. Finally, we summarize current technological bottlenecks and propose interdisciplinary solutions to address these challenges. The prospects of MNRs in dynamic repair and regenerative medicine are also discussed. Our goal is to provide a comprehensive reference and offer guidance for rationally designing versatile MNRs for advanced bone tissue engineering, thereby bridging the gap between tiny active MNRs and traditional bone tissue engineering by making full use of the anatomical structures of healthy bones and the abnormal structures of diseased or injured bones.

骨缺损的修复在平衡材料性能和生物相容性方面提出了重大挑战。虽然合金等传统材料被广泛使用，但它们在机械适应性、骨整合能力和成像干扰方面仍然存在局限性。近年来，生物可降解材料与3D打印技术的结合为个性化骨修复提供了新的途径，但这些支架的植入往往需要开放性手术，给患者带来疼痛，增加感染风险，延长愈合时间。在这种情况下，微型和纳米机器人（MNRs）由于其独特的优势，如微小的尺寸、精确的输送和动态调制能力，可以为微创甚至非侵入性的精密骨组织工程提供开创性的机会。本文重点探讨了微磁共振在骨修复中的应用潜力，系统考察了其设计前提条件：在骨组织的管状结构（如血管和淋巴管）、腔状结构（如骨髓腔和关节腔）和缺陷空间（如骨折和骨质疏松症）内实现定向运动，并分析了其材料选择、推进机制和实时监测策略。此外，我们回顾了mnmr辅助骨缺损再生、骨感染控制和骨肿瘤治疗的最新进展，强调了它们在通过递送生长因子、干细胞或治疗剂来调节局部骨微环境方面的优势。最后，我们总结了当前的技术瓶颈，并提出了跨学科的解决方案来应对这些挑战。并对纳米核磁共振在动态修复和再生医学中的应用前景进行了展望。我们的目标是充分利用健康骨骼的解剖结构和患病或损伤骨骼的异常结构，为高级骨组织工程合理设计多功能磁阻器提供全面的参考和指导，从而弥合微型活性磁阻器与传统骨组织工程之间的差距。

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引用次数: 0

Corrigendum to “Physical stimulus-triggered dynamic therapy based on two-dimensional sensitizers” [Coord. Chem. Rev. 549 (2026) 217315] “基于二维致敏剂的物理刺激触发的动态疗法”的勘误表[Coord. Chem.]。Rev. 549 (2026) 217315]

IF 23.5 1区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Coordination Chemistry Reviews

Pub Date : 2026-01-17 DOI: 10.1016/j.ccr.2026.217591

Yao Zhu , Albert Yu , Zihan Lv , Yue Wang , Zhongjian Xie

引用次数: 0

Cooperative, anti-cooperative, and synergistic supramolecular interactions mediate self-organization of self-assembling dendrons, dendrimers, and dendronized macromolecules 合作、反合作和协同的超分子相互作用介导自组装树突、树突大分子和树突化大分子的自组织

IF 23.5 1区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Coordination Chemistry Reviews

Pub Date : 2026-01-17 DOI: 10.1016/j.ccr.2026.217588

Virgil Percec , Dipankar Sahoo , Devendra S. Maurya , Jasper Adamson

After a brief discussion of the discovery of covalent and self-organizable dendrons, dendrimers, and dendronized macromolecules, examples of cooperative, anti-cooperative and synergistic supramolecular-interactions mediating self-assembly and self-organization of supramolecular dendrimers will be presented. Dendronized crown-ethers will be used to demonstrate these interactions generated by cation-dipole, π–π stacking, H-bonding, fluorination, the specialty of Professor Giuseppe Resnati celebrated with this occasion, and covalent macromolecular interactions. It will be demonstrated that fluorination of self-assembling dendrons generates a simple approach to dendronized donors and acceptors and of their donor-acceptor complexes. The evolution of helical chirality from its discovery in tobacco mosaic virus-like supramolecular dendrimers to helical-globular-dendrimers producing chiral Frank-Kasper and quasicrystal periodic and quasiperiodic arrays will be highlighted. Helical Aquaporin-like transmembrane proteins and spherical containers will be assembled from dendritic dipeptides by a combination of H-bonding and aromatic π–π interactions. The work of Giulio Natta will be honored by a discussion of the dendronized helical stereoisomers of poly(phenylacetylene) and their intramolecular electrocyclization. Polymer chemistry will be employed as a tool to support the quasi-equivalence of self-assembling dendrons and elaborate their shape inversion from helical spheres to helical columns. Helical supramolecular dendrimers induce a helical conformation into atactic-polymer backbones, a dream which even Giulio Natta could not think of. Hydrophobic, H-bonding and ion-ion interactions generated self-assembling amphiphilic Janus dendrimers and glycodendrimers which mimic cell membranes, their glycans, and provide one-component multifunctional sequence-defined ionizable amphiphilic Janus dendrimers which target the delivery of mRNA to specific organs for stable vaccines and therapeutics.

在简要讨论了共价和自组织树突、树突大分子和树突大分子的发现之后，将介绍协同、反协同和协同超分子相互作用介导超分子树突自组装和自组织的例子。树突冠醚将用于演示阳离子偶极子、π -π堆叠、氢键、氟化（Giuseppe Resnati教授的专业）和共价大分子相互作用产生的相互作用。将证明，自组装树突的氟化产生了一种简单的方法来研究树突化的供体和受体及其供体-受体复合物。从烟草花叶病毒样超分子树状大分子中发现螺旋手性到产生手性Frank-Kasper和准晶体周期和准周期阵列的螺旋-球形树状大分子的演变将被重点介绍。螺旋水通道蛋白样跨膜蛋白和球形容器将由树突状二肽通过氢键和芳香π -π相互作用组合而成。Giulio Natta的工作将通过对聚（苯乙炔）的枝状螺旋立体异构体及其分子内电环化的讨论而得到表彰。高分子化学将作为一种工具来支持自组装树突的准等效性，并阐述它们从螺旋球体到螺旋柱的形状转换。螺旋状的超分子树状大分子诱导成无链聚合物骨架的螺旋构象，这是连朱利奥·纳塔都无法想象的梦想。疏水、氢键和离子相互作用产生自组装的两亲性Janus树状大分子和糖状树状大分子，它们模拟细胞膜及其聚糖，并提供单组分多功能序列定义的可电离的两亲性Janus树状大分子，其目标是将mRNA递送到特定器官，用于稳定的疫苗和治疗。

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引用次数: 0

Small-molecule fluorescent probes for sulfur redox biology in oxidative stress 氧化应激中硫氧化还原生物学的小分子荧光探针

IF 23.5 1区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Coordination Chemistry Reviews

Pub Date : 2026-01-17 DOI: 10.1016/j.ccr.2026.217597

Jie Zhang , Xing Wei , Yong Deng , Xiaofeng Wu , Wei Chen

Oxidative stress, driven by redox imbalance, is a pivotal pathological process underpinning major diseases such as cancer, neurodegenerative disorders, and cardiovascular conditions. Reactive sulfur species (RSS) and sulfur-related proteins serve as central regulators within this network, yet their real-time monitoring remains challenging due to low abundance and high reactivity. Small-molecule fluorescent probes, with their high spatiotemporal resolution and biocompatibility, have emerged as indispensable tools for elucidating sulfur redox biology in living systems. This review systematically summarizes recent advances in the rational design and biological applications of fluorescent probes for RSS and sulfur-related proteins, with a dedicated focus on oxidative stress models-including cellular damage, inflammation, and in vivo disease models. We critically analyze probe mechanisms, performance metrics, and translational potential, while highlighting pioneering studies that link RSS and sulfur-related proteins fluctuations to disease pathogenesis. Furthermore, we identify key challenges such as limited tissue penetration, irreversible detection schemes, and the need for reversible/real-time monitoring. By integrating chemical, biological, and medical perspectives, this work not only provides a comprehensive resource for researchers but also outlines future directions for probe development and therapeutic innovation in redox-related diseases

氧化应激由氧化还原失衡驱动，是癌症、神经退行性疾病和心血管疾病等重大疾病的关键病理过程。活性硫物质（RSS）和硫相关蛋白在该网络中起着中心调节作用，但由于其丰度低且反应性高，因此对其进行实时监测仍然具有挑战性。小分子荧光探针具有高时空分辨率和生物相容性，已成为阐明生命系统中硫氧化还原生物学不可缺少的工具。本文系统总结了RSS和硫相关蛋白荧光探针的合理设计和生物学应用的最新进展，重点关注氧化应激模型，包括细胞损伤、炎症和体内疾病模型。我们批判性地分析探针机制、性能指标和转化潜力，同时强调将RSS和硫相关蛋白波动与疾病发病机制联系起来的开创性研究。此外，我们确定了关键挑战，如有限的组织穿透，不可逆检测方案，以及对可逆/实时监测的需求。通过整合化学、生物学和医学的观点，这项工作不仅为研究人员提供了全面的资源，而且还概述了氧化还原相关疾病的探针开发和治疗创新的未来方向

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引用次数: 0

Stable and isolable carbanions: synthesis, chemical bonding, and unique applications 稳定和可分离的碳离子：合成，化学键和独特的应用

IF 23.5 1区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Coordination Chemistry Reviews

Pub Date : 2026-01-16 DOI: 10.1016/j.ccr.2025.217522

Hikaru Yanai

Carbanions were widely regarded as unstable and highly reactive species. However, in fact, the first example of stable and isolable carbanion-containing salts was reported more than 120 years ago. Recent research of stable carbanions endowed a renewed context such as carbanionic “substituents” for tuning the physicochemical properties of organic materials. In addition, unique electronic and geometric structures of the anionic carbon atom enable to be used as ionic liquids, polymer materials, and electrolytes. This review summarises notable recent advances in stable carbanions, covering their synthetic methodologies, chemical bonding behaviour, coordination chemistry, and emerging applications. In particular, carbanions stabilised by cyano, fluorinated sulfonyl, and phosphonio groups are discussed.

碳离子被广泛认为是一种不稳定的高活性物质。然而，事实上，第一个稳定和可分离的含碳盐的例子是在120多年前报道的。近年来对稳定碳离子的研究为调整有机材料的物理化学性质提供了新的背景，例如碳离子“取代基”。此外，阴离子碳原子独特的电子和几何结构使其可以用作离子液体、聚合物材料和电解质。本文综述了近年来稳定碳的研究进展，包括稳定碳的合成方法、化学键行为、配位化学和新兴应用。特别讨论了氰基、氟化磺酰基和膦基稳定的碳离子。

引用次数: 0

Molecular devices based on the mechanical bond: recent advances 基于机械键的分子装置：最新进展

IF 23.5 1区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Coordination Chemistry Reviews

Pub Date : 2026-01-14 DOI: 10.1016/j.ccr.2026.217583

Leonardo Andreoni , Chiara Taticchi , Brian Sachini , Alberto Credi

The bottom-up construction and operation of nanoscale devices – namely, multicomponent (supra)molecular architectures capable of performing functions beyond the reach of their individual components – constitute a central focus in nanoscience and a compelling challenge in nanotechnology. Over the past three decades, the development of artificial molecular devices, including molecular machines and motors, has continuously stimulated the creativity of chemists, and the field continues to evolve at a remarkable pace. Among the strategies employed, the mechanical bond has emerged as a particularly powerful means of connecting molecular components to build functional systems. Mechanically interlocked molecules uniquely combine the robustness of covalent frameworks with the dynamic properties of non-covalent assemblies. Moreover, the precise modulation of steric and electronic interactions between mechanically bonded components offers rich opportunities for the emergence of novel functions. Recent advances in the design and synthesis of rotaxanes, catenanes and related interlocked structures have enabled the construction and operation of increasingly complex molecular devices and materials, many of which are capable of executing well-defined tasks. In this review, we present selected examples – classified according to their functional outputs – that exemplify the progress and potential of this rapidly developing area over the past decade.

纳米器件自下而上的构建和操作——即多组分（supra）分子结构，能够执行超出其单个组分所能达到的功能——构成了纳米科学的中心焦点，也是纳米技术的一个引人注目的挑战。在过去的三十年里，包括分子机器和马达在内的人工分子装置的发展不断激发着化学家的创造力，这一领域继续以惊人的速度发展。在所采用的策略中，机械键已成为连接分子组分以构建功能系统的一种特别强大的手段。机械互锁分子独特地结合了共价框架的鲁棒性和非共价组件的动态特性。此外，机械键合组件之间的空间和电子相互作用的精确调制为新功能的出现提供了丰富的机会。轮烷、链烷和相关联锁结构的设计和合成的最新进展使越来越复杂的分子器件和材料的构建和操作成为可能，其中许多能够执行明确定义的任务。在本次审查中，我们提出了一些根据其功能产出分类的例子，这些例子说明了过去十年来这一迅速发展领域的进展和潜力。

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引用次数: 0

Developments of one-dimensional (1D) covalent organic frameworks: A comprehensive review 一维共价有机骨架的研究进展：综述

IF 23.5 1区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Coordination Chemistry Reviews

Pub Date : 2026-01-14 DOI: 10.1016/j.ccr.2025.217558

Jingying Tan , Pengzhong Shi , Ziao Chen , Yanfeng Yue , Zhiyong Guo

CONSPECTUS: As a new type of crystalline porous material, covalent organic frameworks (COFs) have demonstrated remarkable application potential in various fields. However, most current research on COFs concentrated on two-dimensional (2D) and three-dimensional (3D) structures. In contrast, the development of 1D COF which structure extends in only one direction is relatively late and immature. The dual-chain-like edge architecture in 1D COF contributes to the stabilization of aromatic backbones, the enhancement of electronic conjugation, and the reduction of energy loss. This allows the 1D COF to exhibit superior performance compared to 2D COFs in applications such as catalysis and photoelectric/optoelectronic applications. It systematically summarized the synthetic principle of 1D COFs, principle including the topological structure, compositional modular structures, linkage and other derived structures. And then, it briefly discussed the general structure/composition characterization techniques for 1D COFs. Lastly, it outlined the main applications of 1D COFs in heterogenous catalysis, optoelectronic application, energy storage and conversion, sensing application, and selective adsorption. This review also proposed crucial guidance for the future development of 1D COFs.

摘要：共价有机骨架（COFs）作为一种新型的晶体多孔材料，在各个领域都显示出了显著的应用潜力。然而，目前对COFs的研究大多集中在二维（2D）和三维（3D）结构上。相比之下，结构只向一个方向延伸的一维碳纳米管的发展相对较晚和不成熟。一维碳纳米管的双链边缘结构有助于芳香骨架的稳定、电子共轭的增强和能量损失的降低。这使得1D COF在催化和光电/光电应用等应用中表现出优于2D COF的性能。系统总结了一维COFs的合成原理，原理包括拓扑结构、组合模块化结构、连杆结构和其他衍生结构。然后，简要讨论了一维COFs的一般结构/组成表征技术。最后概述了1D COFs在多相催化、光电、储能与转换、传感和选择性吸附等方面的主要应用。本综述还为1D COFs的未来发展提出了重要的指导意见。

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引用次数: 0

+Organometallic chemistry of vanadium-, niobium-alkylidene complexes: Emerging promising catalysts in olefin metathesis +钒、铌-烷基烯配合物的有机金属化学：烯烃分解中新兴的有前途的催化剂

IF 23.5 1区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Coordination Chemistry Reviews

Pub Date : 2026-01-13 DOI: 10.1016/j.ccr.2026.217572

Kotohiro Nomura

This review summarizes reports for synthesis of vanadium-, niobium-alkylidene complexes (complexes containing metal‑carbon double bonds) and the related reaction chemistry especially over the past 30 years (1995–2025). Some of these alkylidene complexes demonstrate promising capability as catalysts for olefin metathesis reactions such as highly active and thermal resistant (stereospecific) ring opening metathesis polymerization (ROMP) of cyclic olefins, living metathesis polymerization of internal alkynes, and ring closing metathesis (RCM) reactions. Some metal-alkylidene, alkyl-alkylidene complexes also display unique reactivities in activation of small molecules through CH bond activation.

本文综述了近30年来钒、铌烷配合物（含金属碳双键配合物）的合成及其反应化学的研究进展。其中一些烷基烯配合物在环烯烃的高活性和耐热（立体定向）开环复分解聚合（ROMP）、内炔的活性复分解聚合和闭环复分解反应（RCM）等反应中表现出良好的催化性能。一些金属-烷基二烯、烷基-烷基二烯配合物也表现出独特的通过CH键活化小分子的反应活性。

引用次数: 0

Optical imaging probes for mitochondrial metabolism: Mechanism, design and frontier applications 线粒体代谢光学成像探针：机制、设计和前沿应用

IF 23.5 1区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Coordination Chemistry Reviews

Pub Date : 2026-01-13 DOI: 10.1016/j.ccr.2026.217570

Shiping Yuan , Yankun Zhao , Shujuan Liu , Yishan Gao , Liangcan He , Shaoqin Liu

Mitochondria are pivotal organelles in eukaryotic cells, intricately linked to cellular functions and energy metabolism. Mitochondrial metabolic processes can be induced by intracellular or extracellular factors, leading to alterations in metabolite levels and subsequent mitochondrial dysfunction and related diseases. Consequently, developing noninvasive, real-time imaging techniques capable of monitoring mitochondrial metabolites in complex biological systems is crucial for elucidating the relationship between mitochondrial metabolism and disease mechanisms. Optical imaging technology, with its advantages of noninvasiveness and high spatiotemporal resolution, has emerged as a powerful tool for studying mitochondrial metabolic activities. This review begins with the structure and energy metabolism of mitochondria, discussing the correlation between metabolites and mitochondrial activity. It then focuses on the emission mechanisms and functional design strategies of various optical materials, including small-molecule fluorophores, semiconducting polymer nanoparticles (SPNs), aggregation-induced emission (AIE) materials, and lanthanide metal complexes, while summarizing their applications in detecting mitochondrial metabolites. Finally, the limitations and challenges of optical imaging in clinical translation are discussed.

线粒体是真核细胞中的关键细胞器，与细胞功能和能量代谢有着复杂的联系。线粒体代谢过程可由细胞内或细胞外因素诱导，导致代谢物水平的改变和随后的线粒体功能障碍和相关疾病。因此，开发能够监测复杂生物系统中线粒体代谢物的无创实时成像技术对于阐明线粒体代谢与疾病机制之间的关系至关重要。光学成像技术以其非侵入性和高时空分辨率的优势，成为研究线粒体代谢活动的有力工具。本文从线粒体的结构和能量代谢入手，讨论了代谢物与线粒体活性的关系。然后重点介绍了各种光学材料的发射机制和功能设计策略，包括小分子荧光团、半导体聚合物纳米颗粒（SPNs）、聚集诱导发射（AIE）材料和镧系金属配合物，同时总结了它们在检测线粒体代谢物方面的应用。最后，讨论了光学成像在临床翻译中的局限性和挑战。

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引用次数: 0

From monomodal to multimodal: The intelligent evolution of photoelectric nanozymes in food safety detection sensing 从单模态到多模态：光电纳米酶在食品安全检测传感中的智能进化

IF 23.5 1区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Coordination Chemistry Reviews

Pub Date : 2026-01-13 DOI: 10.1016/j.ccr.2026.217590

Jiaqi Song , Yue Xu , Yang Yang, Guang Zhang, Xinyu Xu, Jiawang Wang, Chunmin Ma, Na Zhang

Food safety as a global major public health issue, has put forward an urgent demand for highly sensitive, reliable, and onsite rapid detection technologies. Although traditional analytical methods are accurate, they are cumbersome to operate. Early biosensors based on nanozymes solved the stability problem of natural enzymes, but were limited by single-modality sensing strategies, facing the bottlenecks of weak anti-interference ability and insufficient information dimension in complex food matrices. This review systematically discusses how the sensing paradigm for food safety detection has achieved a profound evolution from monomodal to multimodal and finally to artificial intelligence (AI) driven intelligence through the core material of photoelectric nanozymes (PENz). In this paper, PENz material library covering noble metals, metal oxides, carbon-based materials, Metal Organic Frameworks (MOFs) and their derivatives was first constructed, and the synergistic mechanism of their photo-electric-enzyme triple activities was elucidated. Furthermore, the strategic evolution from monomodal sensing to multimodal integration, such as photo-electric, photo-photo, and photo-electric-photo, as well as its applications in the field of food safety detection, were analyzed in detail. The core advantage of multimodal sensing in improving the accuracy and reliability of detection through signal cross validation is emphasized. Finally, the enabling role of AI technology in intelligent analysis of multi-modal data, accurate prediction of pollutants, and rational design of novel nanozymes was discussed. This paper aims to provide a clear theoretical blueprint and technical path for the future construction of an intelligent and onsite food safety monitoring system.

食品安全作为全球性重大公共卫生问题，对高灵敏度、高可靠性、现场快速检测技术提出了迫切需求。传统的分析方法虽然准确，但操作繁琐。早期基于纳米酶的生物传感器解决了天然酶的稳定性问题，但受到单模态传感策略的限制，在复杂的食物基质中面临抗干扰能力弱和信息维数不足的瓶颈。本文系统讨论了以光电纳米酶（PENz）为核心材料的食品安全检测传感范式如何实现从单模态到多模态，最后到人工智能驱动的智能的深刻演变。本文首先构建了涵盖贵金属、金属氧化物、碳基材料、金属有机框架（mof）及其衍生物的PENz材料库，并阐明了它们的光电-酶三重活性协同机制。详细分析了从单模传感到光电、光电、光电-光电等多模态集成的战略演变及其在食品安全检测领域的应用。强调了多模态传感在通过信号交叉验证提高检测精度和可靠性方面的核心优势。最后，讨论了人工智能技术在多模态数据的智能分析、污染物的准确预测和新型纳米酶的合理设计方面的作用。本文旨在为未来构建智能化、现场化的食品安全监控系统提供清晰的理论蓝图和技术路径。

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引用次数: 0