Coordination Chemistry Reviews最新文献

Despite the progress of alternative/renewable energy technologies (solar, wind, hydroelectric, geothermal, nuclear, hydrogen, bio, tidal and wave), still the fossil raw materials such as petroleum (crude oil), natural gas and coal remain the main source of energy. The major constituents of crude oil (ca. 20–50 %) and natural gas (ca. 95 % methane, 4 % ethane, 0.2 % propane and 0.02 % butane) are alkanes, which are stable molecules due to high bond dissociation enthalpy of C_sp3 − H (96–105 kcal/mol) and C_sp3 – C_sp3 (83–90 kcal/mol) bonds. Due to the low cost and high richness in carbon, alkanes are fundamental feedstocks in chemical industry and starting materials in the synthesis of value-added products. In contrast to unselective classic radical mechanism, the metal complex catalysed direct activation of chemical inert C_sp3 − H and C_sp3 – C_sp3 bonds in alkanes concerns extremely important synthetic transformations with high economic impact. This review is aimed to provide an overview on recent (2019–2023) advances in homogenous metal free and metal complex catalysed activation and functionalization of alkanes leading to CC or C_sp3 − Element bonds. Instead of a comprehensive review, herein a special attention is focused on selected new synthetic strategies and reaction mechanisms in C_sp3 − H functionalization in alkanes.

Hydrogel-integrated nanostructures offer a novel approach to cancer therapy by combining hydrogels' biocompatibility and tunable drug release with nanotechnology. These nanoplatforms enhance treatment precision and efficacy while minimizing side effects, providing a sophisticated and targeted delivery system. This comprehensive review explores synergistic cancer therapies utilizing hydrogel-integrated nanoplatforms, which employ dual strategies to enhance their anticancer efficacy. These strategies include chemodynamic therapy (CDT), photothermal therapy (PTT), photodynamic therapy (PDT), immunotherapy, radiotherapy (RT), gene therapy (GT), and magnetic hyperthermia therapy (MHT). Such platforms have the potential to overcome multidrug-resistant cancers, pioneer innovative treatment modalities, and improve patient survival rates compared to monotherapies. However, challenges such as scalability, regulatory approval, optimizing drug release kinetics, and addressing potential toxicity concerns remain, which are critical for assessing their long-term effects and clinical applicability.

Persistent luminescence materials (PLMs) are unique as their afterglow emission. The distinctive non-in-situ excitation mechanism could eliminate interference from autofluorescence and scattered light, enabling high sensitivity for optical imaging applications. Additionally, PLMs can be integrated with metal ions, photothermal species, photosensitizers, therapeutic drugs, nucleic acid, or immunological adjuvants to realize imaging-guided therapy. In this review, we summarized the advancements in the synthesis and emission mechanisms of inorganic, organic, and hybrid PLMs. We also discussed their applications in optical imaging in terms of excitation sources, such as X-ray, UV, light-emitting diodes, NIR lasers, thermal, radiopharmaceuticals, and ultrasound. Further, the theranostic applications of PLMs were summarized, including imaging-guided chemotherapy, photothermal therapy, photodynamic therapy, gene therapy, immunotherapy, and multi-modality therapy. The bioapplications of PLMs in tumour ablation, bacterial infection, inflammation, rheumatoid arthritis, atherosclerosis, and osteoporosis are also introduced. Besides, persistent luminescence imaging-guided surgical navigation without the need of real-time excitation could simplify the instrumentation and provide high precision for tumour elimination, and we introduce several examples of surgical navigation. Finally, the toxicity concerns associated with PLMs are discussed. The challenges, potential problems, and prospects regarding the translational medicine applications of PLMs are outlooked.

Amino acids provide a convenient, economical, and non-toxic route for the synthesis of chiral metallosupramolecular architectures, including coordination cages and metal–organic cages, metallocycles, and metallocatenanes. In this review, we collate recent works on supramolecular coordination complexes assembled with amino acid derivatives, while highlighting the role of the amino acid on the chirality, coordination chemistry, and supramolecular chemistry of these complexes.

Cobalt ferrite, an anomaly among the other spinel ferrites, have continuously captured the consideration of various researchers across the different disciplines due to its inimitable traits and characteristics. In contrast to their spinel ferrite counterparts, the cobalt ferrite exhibits high coercivity, excellent dielectric properties, and significant catalytic behavior, making it a subject of intense investigation and exploration. Despite the extensive research that has been conducted on the cobalt ferrites, there is still no available comprehensive and definitive explanation regarding their structural, magnetic, dielectric, and catalytic traits. Consequently, here the aim is to consolidate and present the potential applicability of cobalt ferrite, while simultaneously drawing the connections to the properties of cobalt ferrite. This comprehensive review aims to elucidate the intricate structural dynamics of cobalt ferrite, and the complexities of its inverse characteristics. The profound implications of inverse nature of cobalt ferrite on its magnetic, catalytic, and dielectric behaviors has also been analysed. Furthermore, this review will also prove helpful for the researchers exploring the potential usage of cobalt ferrites for various applications, thus improving the basic understating of cobalt ferrite behavior.

Bacterial infection in wounds is a complex and multilayered process, increasing the complexity and challenges of treatment. It often leads to infection, a deeper inflammatory response and a multifaceted slowing down of the wound repair process. Therefore, addressing these unique challenges requires focused and effective treatment strategies aimed at achieving optimal therapeutic outcomes and preventing complications. With rapid advancements in nanomaterials, catalytic techniques, and biotechnology, copper-based nanomaterials, as commonly used nanomaterials, exhibit excellent physicochemical properties, such as efficient catalytic, optical, thermal, or electrical characteristics, and are widely applied in wound management. To develop efficient and mature therapies for bacterial infection in wounds, a comprehensive understanding of the treatment strategies and mechanisms of copper-based nanomaterials in this context is essential. In this review, we systematically summarize the progress in the use of copper-based nanomaterials for treating bacterial infection in wounds, including the types of materials, treatment strategies, and mechanisms of action. We emphasize the unique advantages of different types of copper-based materials in treatment, diverse treatment modalities, and their mechanisms in terms of antibacterial, anti-inflammatory, or wound healing promotion. Finally, we discuss current challenges and the understanding and perspectives that have the potential to contribute to the development of treatments for bacterially infected wounds.

Food safety hazards pose a serious threat to human health and public safety. The development of rapid and accurate detection technologies for food hazards is, therefore, of paramount importance. Nanomaterial-based detection technology has solved the limitations of traditional detection methods, such as long detection time and high cost. However, most current biosensors still rely on single-signal outputs, which are susceptible to the influence of the food matrix, leading to errors in the detection signal and affecting the reliability of the results. To overcome these challenges, the development of biosensors with built-in self-calibration mechanisms holds great promise. Sensors with built-in self-calibration can make a sensing matrix output signals of different frequencies through different combinations of nanomaterials, and the reversibility or synergistic changes between these signals make the determination of the concentration of the target analyte closer to the real value. This innovative approach to ultra-precise trace detection of hazards in complex food matrices is a significant advancement in the field of food safety. This paper provides a comprehensive overview of the synthesis and application form of signal-labeled nanomaterials, and outlines the underlying principles and application scenarios of the ultra-precision detection platform for food hazards based on built-in self-calibration. Furthermore, this paper also discusses the limitations and the prospective outlook of sensors based on the internal self-calibration mode to stimulate strategic innovation of ultra-precision sensing modes, ultimately safeguarding food safety.

Huntington's Disease (HD) is a severe neurodegenerative disorder lacking effective diagnostic and treatment options. However, there is increasing interest in the potential of nanotherapeutics to address this challenging condition. Nanotherapeutics, characterized by their distinct capacity for precise targeting and delivery of therapeutic agents to designated sites, exhibit considerable potential in the treatment of HD by addressing intricate molecular pathways. By utilizing different nanocarriers, nanotherapeutics can efficiently navigate the blood-brain barrier (BBB) and deliver therapeutic payloads directly to affected regions of the HD brain, thereby mitigating adverse effects and enhancing treatment efficacy. This review comprehensively addresses complexities associated with drug delivery to the HD-affected brain. Furthermore, it explores the design of various nanotherapeutics, elucidating the mechanism of therapeutic delivery to the brain, and their therapeutic effects in HD models. Moreover, the potential of nanotherapeutics as diagnostics in HD therapy is also explored. Despite extant challenges, such as the imperative for stringent safety assessments and the absence of FDA-endorsed nanotherapeutics for HD, the rapid progress in nanotherapeutic research unveils a diverse array of prospects capable of revolutionizing HD treatment.

Although transition metals make up less than 0.1 % of the total mass in a human body, they have significant impacts on fundamental biological processes. Among them, copper(I) (Cu⁺), copper(II) (Cu²⁺), ferrous ion (Fe²⁺) and ferric ion (Fe³⁺) exhibited many vital biochemical events. Therefore, precisely monitoring their biological distribution and concentrations via modern analytical techniques are urgently required. In particular, small molecule fluorescent probes have enabled the real-time and in suit detection of the dynamic fluctuations and spatiotemporal distribution of these transition metal ions. In this work, abundant representative binding- and activity-based small molecule fluorescent probes for monitoring of Cu⁺, Cu²⁺, Fe²⁺ and Fe³⁺ from 2020 to 2024 are showcased. Moreover, the molecular design strategies, monitoring mechanisms, and biological applications of these fluorescence probes are described in detail. Furthermore, the strengths and weaknesses of various types of metal ion-responsive molecular probes are analyzed and discussed. In this regard, our underlying goal is to encourage the development of innovative small molecule fluorescent probes for detecting transition metal ions.

Lipid droplets (LDs) have recently garnered significant attention due to their pivotal roles in life and diseases. Thus, seeking suitable tools to visualize the dynamics of LDs and reveal their mysterious functions is particularly important. Organic fluorescent probes provide significant advantages in terms of excellent sensitivity, high selectivity, and remarkable spatial resolution for the in situ and real-time detection and monitoring of diverse biological species. This review summarizes recent progress on organic fluorescent probes for the dynamic imaging of LDs in biological applications. First, the design principles of fluorescent LD probes are briefly described. The subsequent sections present versatile applications involving the use of representative fluorescent LD probes for super-resolution imaging, analyte sensing, organelle interaction visualization, and theranostics. Finally, we discuss our understanding and opinions regarding further directions for the development of high-performance LD probes. This review provides new insights to advance our understanding of LDs and is expected to inspire the design of more intelligent and powerful fluorescent LD probes.