Pub Date : 2025-02-27DOI: 10.1016/j.ccr.2025.216570
Peng Liu , Yajie Zhao , Ying Peng , Jessica C. Hsu , Ming Zhou , Wenhu Zhou , Shuo Hu , Weibo Cai
Acute kidney injury (AKI), a severe complication marked by a sudden decline in renal function, is a significant public health concern with high morbidity and mortality rates. The early diagnosis and effective treatment of AKI remain challenging due to the complex etiology and pathophysiology of the disease. Nanoagents have emerged as a promising strategy for improving AKI management by enabling early detection, monitoring disease progression and enhancing treatment efficacy. This review provides a comprehensive overview of the recent advances in nanoagent-based approaches for AKI imaging and treatment. We first discuss the pathophysiological characteristics of AKI and their influence on nanoparticle targeting, accumulation, and clearance in diseased renal tissues. Next, we present a variety of nanoagent-based imaging techniques for monitoring kidney function and diagnosing AKI. We also outline the therapeutic principles of AKI and summarize the broad array of nanotherapeutic agents developed for AKI treatment. Finally, the review discusses the challenges of bringing nanoagent research into clinical use and explores future directions, emphasizing key opportunities to drive progress in this field.
{"title":"Harnessing the power of nanoagents in acute kidney injury: A versatile platform for imaging and treatment","authors":"Peng Liu , Yajie Zhao , Ying Peng , Jessica C. Hsu , Ming Zhou , Wenhu Zhou , Shuo Hu , Weibo Cai","doi":"10.1016/j.ccr.2025.216570","DOIUrl":"10.1016/j.ccr.2025.216570","url":null,"abstract":"<div><div>Acute kidney injury (AKI), a severe complication marked by a sudden decline in renal function, is a significant public health concern with high morbidity and mortality rates. The early diagnosis and effective treatment of AKI remain challenging due to the complex etiology and pathophysiology of the disease. Nanoagents have emerged as a promising strategy for improving AKI management by enabling early detection, monitoring disease progression and enhancing treatment efficacy. This review provides a comprehensive overview of the recent advances in nanoagent-based approaches for AKI imaging and treatment. We first discuss the pathophysiological characteristics of AKI and their influence on nanoparticle targeting, accumulation, and clearance in diseased renal tissues. Next, we present a variety of nanoagent-based imaging techniques for monitoring kidney function and diagnosing AKI. We also outline the therapeutic principles of AKI and summarize the broad array of nanotherapeutic agents developed for AKI treatment. Finally, the review discusses the challenges of bringing nanoagent research into clinical use and explores future directions, emphasizing key opportunities to drive progress in this field.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"533 ","pages":"Article 216570"},"PeriodicalIF":20.3,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143507370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-27DOI: 10.1016/j.ccr.2025.216549
Long He , Yi Li , Chonghua Zhang , Xingxing Zhang , Benhua Wang , Tianbing Ren , Lin Yuan
Small-molecule photothermal agents (PTAs) working in second near-infrared (NIR-II) region exhibited a great potential of cancer treatment and diagnosis for the advantages of minimal side effect, deeper penetration ability of tissue, and easily adjustable of structure. Various small-molecule PTA that integrate NIR-II fluorescence/photoacoustic (PA) imaging and thermal effect can visualize tumor locations and thermally irradiate tumor in real time, holding significant potential for early diagnosis and precision treatment of cancer. In this review, we summarize various strategies to improve the photothermal therapy (PTT) effects of small-molecule PTAs for NIR-II imaging-guided cancer treatment, including the enhancement of photothermal conversion efficiency (PCE) and photostability, the improvement of biocompatibility and specificity, and the facilitation of PTT by synergistic therapy. The perspectives and obstacles associated with NIR-II small-molecule PTAs for application are also discussed.
{"title":"Development of small-molecule NIR-II photothermal agents for image-guided tumor therapy","authors":"Long He , Yi Li , Chonghua Zhang , Xingxing Zhang , Benhua Wang , Tianbing Ren , Lin Yuan","doi":"10.1016/j.ccr.2025.216549","DOIUrl":"10.1016/j.ccr.2025.216549","url":null,"abstract":"<div><div>Small-molecule photothermal agents (PTAs) working in second near-infrared (NIR-II) region exhibited a great potential of cancer treatment and diagnosis for the advantages of minimal side effect, deeper penetration ability of tissue, and easily adjustable of structure. Various small-molecule PTA that integrate NIR-II fluorescence/photoacoustic (PA) imaging and thermal effect can visualize tumor locations and thermally irradiate tumor in real time, holding significant potential for early diagnosis and precision treatment of cancer. In this review, we summarize various strategies to improve the photothermal therapy (PTT) effects of small-molecule PTAs for NIR-II imaging-guided cancer treatment, including the enhancement of photothermal conversion efficiency (PCE) and photostability, the improvement of biocompatibility and specificity, and the facilitation of PTT by synergistic therapy. The perspectives and obstacles associated with NIR-II small-molecule PTAs for application are also discussed.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"533 ","pages":"Article 216549"},"PeriodicalIF":20.3,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143507369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-27DOI: 10.1016/j.ccr.2025.216555
Wei Zhang , Mao-Qin Liu , Yang Luo
Supramolecular light-harvesting systems constructed based on SS-FRET and TS-FRET are promising for chemical sensing leadership, information encryption, biomedical imaging, etc. These systems typically exhibit extremely large Stokes shifts, high quantum yields, and long-wavelength-emitting fluorescence (especially in the near-infrared) with tunable colors. This review summarizes cucurbit[n]urils-based supramolecular light-harvesting systems that restrict the rotation and vibration of organic fluorescent/phosphorescent molecules, and briefly discusses ALHSs based on other macrocyclic compounds and their functional applications. A wide range of cucurbit[n]urils are encompassed for practical reading value, including single-cavity Q[n]s, (n = 5–8, 10) and double-cavity tQ[13–15]) and ns-Q[10]). The rigid cavity structure and high affinity of Q[n]s could induce spatial confinement effects, which effectively limit or reduce the decay of radiative/non-radiative transitions, promote inter-system crossing, reduce the distance between donor-acceptor pairs, and effectively improve energy transfer efficiency. We contribute to the promotion of the further development of Q[n]s-based FRET systems by discussing and summarizing the advantages, importance, and functional applications of Q[n]s in the construction of FRET systems, e.g., tunable multicolor luminescent materials, information encryption/anti-counterfeiting, photocatalysis, and biologically targeted therapeutics/imaging.
{"title":"Supramolecular light-harvesting systems based on cucurbit[n]urils: SS-FRET and TS-FRET mechanisms and functional applications","authors":"Wei Zhang , Mao-Qin Liu , Yang Luo","doi":"10.1016/j.ccr.2025.216555","DOIUrl":"10.1016/j.ccr.2025.216555","url":null,"abstract":"<div><div>Supramolecular light-harvesting systems constructed based on SS-FRET and TS-FRET are promising for chemical sensing leadership, information encryption, biomedical imaging, etc. These systems typically exhibit extremely large Stokes shifts, high quantum yields, and long-wavelength-emitting fluorescence (especially in the near-infrared) with tunable colors. This review summarizes cucurbit[n]urils-based supramolecular light-harvesting systems that restrict the rotation and vibration of organic fluorescent/phosphorescent molecules, and briefly discusses ALHSs based on other macrocyclic compounds and their functional applications. A wide range of cucurbit[n]urils are encompassed for practical reading value, including single-cavity Q[n]s, (<em>n</em> = 5–8, 10) and double-cavity <em>t</em>Q[13–15]) and <em>ns</em>-Q[10]). The rigid cavity structure and high affinity of Q[n]s could induce spatial confinement effects, which effectively limit or reduce the decay of radiative/non-radiative transitions, promote inter-system crossing, reduce the distance between donor-acceptor pairs, and effectively improve energy transfer efficiency. We contribute to the promotion of the further development of Q[n]s-based FRET systems by discussing and summarizing the advantages, importance, and functional applications of Q[n]s in the construction of FRET systems, e.g., tunable multicolor luminescent materials, information encryption/anti-counterfeiting, photocatalysis, and biologically targeted therapeutics/imaging.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"533 ","pages":"Article 216555"},"PeriodicalIF":20.3,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143507372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-27DOI: 10.1016/j.ccr.2025.216554
Zi Fu , Di Zhou , Zeyang Liu , Dalong Ni
Glutathione (GSH) is a main component of the antioxidant system in organisms, scavenging reactive oxygen species and protecting cells from oxidative stress, thus playing important roles in many physiological processes. An imbalance of GSH level within the microenvironment is a characteristic of many diseases, which makes this biochemical property of the disease site be exploited as a potential target for disease treatment. Recent advances in nanomedicine have led to a proliferation of nanomedicines targeting GSH, with which a variety of emerging imaging and therapeutic modalities have been achieved on multiple disease models. Here, we review recent advances in nanomedicine for diseases characterized by imbalanced GSH levels. First, the design strategies and chemical mechanisms of GSH-responsive nanomedicine are described. Then, we provide a systematic review of the application of GSH-responsive nanomaterials for disease smart imaging including fluorescence imaging, photoacoustic imaging, magnetic resonance imaging and computed tomography imaging. Moreover, GSH-responsive nanomaterials-based tumor smart therapeutic strategies including chemotherapy, phototherapy, chemo-dynamic therapy and ferroptosis are detailedly introduced. An in-depth discussion of current challenges and future prospects for GSH-responsive nanomedicine are given at the end of this review.
{"title":"GSH-responsive nanomedicine for disease smart imaging and therapy","authors":"Zi Fu , Di Zhou , Zeyang Liu , Dalong Ni","doi":"10.1016/j.ccr.2025.216554","DOIUrl":"10.1016/j.ccr.2025.216554","url":null,"abstract":"<div><div>Glutathione (GSH) is a main component of the antioxidant system in organisms, scavenging reactive oxygen species and protecting cells from oxidative stress, thus playing important roles in many physiological processes. An imbalance of GSH level within the microenvironment is a characteristic of many diseases, which makes this biochemical property of the disease site be exploited as a potential target for disease treatment. Recent advances in nanomedicine have led to a proliferation of nanomedicines targeting GSH, with which a variety of emerging imaging and therapeutic modalities have been achieved on multiple disease models. Here, we review recent advances in nanomedicine for diseases characterized by imbalanced GSH levels. First, the design strategies and chemical mechanisms of GSH-responsive nanomedicine are described. Then, we provide a systematic review of the application of GSH-responsive nanomaterials for disease smart imaging including fluorescence imaging, photoacoustic imaging, magnetic resonance imaging and computed tomography imaging. Moreover, GSH-responsive nanomaterials-based tumor smart therapeutic strategies including chemotherapy, phototherapy, chemo-dynamic therapy and ferroptosis are detailedly introduced. An in-depth discussion of current challenges and future prospects for GSH-responsive nanomedicine are given at the end of this review.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"533 ","pages":"Article 216554"},"PeriodicalIF":20.3,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143507326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-27DOI: 10.1016/j.ccr.2025.216560
Xinxin Zhang, Lei Wang, Ying Xie, Honggang Fu
The hydrogen evolution reaction (HER), oxygen evolution reaction (OER), and oxygen reduction reaction (ORR) are crucial half-reactions in energy storage and conversion systems. As ideal alternatives to precious metal catalysts, cobalt (Co)-based catalysts have attracted significant attention due to their adjustable oxidation states, multifunctionality, and structural diversity. Nevertheless, because of the complexities in composition, stoichiometry, and structures, fully understanding the microscopic origin of relevant reaction mechanisms and the inherent structural and performance relationships remains a great challenge. Therefore, utilizing the theoretical descriptors to distinguish and reveal the factors that limit the electrocatalytic activities of the Co-based electrocatalysts is thus of great importance, which is very crucial for appropriate adjustment of the synthetic strategies, the structure/composition optimizations, and finally the enhancement of the electrocatalytic performance. In this review, the computational hydrogen electrode and HER, OER, and ORR mechanisms are first introduced. Then, the performance descriptors related to the conductivity, reactivity, and stability were derived and discussed in-depth from density functional theory (DFT) calculations. Inspired by these descriptors, various strategies to comprehensively optimize the structures and electronic properties of the Co-based catalysts are summarized. Finally, current status, challenges, and future prospects of Co-based catalysts in practical Zn-air batteries (ZABs) and water splitting applications were reviewed.
{"title":"Theoretical insights into performance descriptors and their impact on activity optimization strategies for cobalt-based electrocatalysts","authors":"Xinxin Zhang, Lei Wang, Ying Xie, Honggang Fu","doi":"10.1016/j.ccr.2025.216560","DOIUrl":"10.1016/j.ccr.2025.216560","url":null,"abstract":"<div><div>The hydrogen evolution reaction (HER), oxygen evolution reaction (OER), and oxygen reduction reaction (ORR) are crucial half-reactions in energy storage and conversion systems. As ideal alternatives to precious metal catalysts, cobalt (Co)-based catalysts have attracted significant attention due to their adjustable oxidation states, multifunctionality, and structural diversity. Nevertheless, because of the complexities in composition, stoichiometry, and structures, fully understanding the microscopic origin of relevant reaction mechanisms and the inherent structural and performance relationships remains a great challenge. Therefore, utilizing the theoretical descriptors to distinguish and reveal the factors that limit the electrocatalytic activities of the Co-based electrocatalysts is thus of great importance, which is very crucial for appropriate adjustment of the synthetic strategies, the structure/composition optimizations, and finally the enhancement of the electrocatalytic performance. In this review, the computational hydrogen electrode and HER, OER, and ORR mechanisms are first introduced. Then, the performance descriptors related to the conductivity, reactivity, and stability were derived and discussed in-depth from density functional theory (DFT) calculations. Inspired by these descriptors, various strategies to comprehensively optimize the structures and electronic properties of the Co-based catalysts are summarized. Finally, current status, challenges, and future prospects of Co-based catalysts in practical Zn-air batteries (ZABs) and water splitting applications were reviewed.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"533 ","pages":"Article 216560"},"PeriodicalIF":20.3,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143507327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-27DOI: 10.1016/j.ccr.2025.216540
Junjie Zhang , Haiyang Guo , Longguang Tang , Jiannan Liu , Qiang Fang , Dongliang Yang , Wenpei Fan
Nitric oxide (NO) is a critical signaling molecule with diverse physiological functions and significant therapeutic potential across various diseases. However, its clinical application faces substantial challenges due to its inherently short half-life, rapid diffusion, and potential systemic toxicity. Recent advancements in nanotechnology have enabled the development of sophisticated nanomaterials that precisely control and target NO delivery, thereby overcoming these limitations. This paper provides an in-depth review of cutting-edge NO delivery nanomaterials, emphasizing both organic and inorganic carriers engineered to respond to specific endogenous (e.g., pH, glucose, GSH, etc.) and exogenous (e.g., light, X-rays, ultrasound, etc.) stimuli. The review particularly focuses on the synergistic integration of NO therapy with other modalities such as photothermal therapy, photodynamic therapy, sonodynamic therapy, starvation therapy, immunotherapy, radiotherapy, gene therapy, chemodynamic therapy, and magnetothermal therapy. These versatile nanomaterials have shown significant efficacy in treating complex conditions, including cancer, cardiovascular disorders, inflammatory, and other diseases. Furthermore, the review discusses current challenges in NO delivery technologies, exploring the limitations and potential future developments in this field. By highlighting the latest advances, this paper underscores the promising avenues for translating NO-based therapies into clinical practice, aiming to substantially enhance therapeutic outcomes and improve patient care.
{"title":"Harnessing stimuli-responsive NO nanomaterials for advanced multi-disease therapy","authors":"Junjie Zhang , Haiyang Guo , Longguang Tang , Jiannan Liu , Qiang Fang , Dongliang Yang , Wenpei Fan","doi":"10.1016/j.ccr.2025.216540","DOIUrl":"10.1016/j.ccr.2025.216540","url":null,"abstract":"<div><div>Nitric oxide (NO) is a critical signaling molecule with diverse physiological functions and significant therapeutic potential across various diseases. However, its clinical application faces substantial challenges due to its inherently short half-life, rapid diffusion, and potential systemic toxicity. Recent advancements in nanotechnology have enabled the development of sophisticated nanomaterials that precisely control and target NO delivery, thereby overcoming these limitations. This paper provides an in-depth review of cutting-edge NO delivery nanomaterials, emphasizing both organic and inorganic carriers engineered to respond to specific endogenous (<em>e.g.</em>, pH, glucose, GSH, <em>etc.</em>) and exogenous (<em>e.g.</em>, light, X-rays, ultrasound, <em>etc.</em>) stimuli. The review particularly focuses on the synergistic integration of NO therapy with other modalities such as photothermal therapy, photodynamic therapy, sonodynamic therapy, starvation therapy, immunotherapy, radiotherapy, gene therapy, chemodynamic therapy, and magnetothermal therapy. These versatile nanomaterials have shown significant efficacy in treating complex conditions, including cancer, cardiovascular disorders, inflammatory, and other diseases. Furthermore, the review discusses current challenges in NO delivery technologies, exploring the limitations and potential future developments in this field. By highlighting the latest advances, this paper underscores the promising avenues for translating NO-based therapies into clinical practice, aiming to substantially enhance therapeutic outcomes and improve patient care.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"533 ","pages":"Article 216540"},"PeriodicalIF":20.3,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143507348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-26DOI: 10.1016/j.ccr.2025.216524
Yingying Kong , Guansong Zheng , Yinxia Du , Junjie Li , Shilie Pan
Developing high-performance nonlinear optical (NLO) crystals is an urgent need for advanced photoelectric technologies. However, the discovery of novel infrared (IR) NLO materials with desired properties is challenging. Chalcophosphate, combining the structural advantages of chalcogenide & phosphate, and showing a high probability (∼30 %, much higher than the one of ∼15 % in the inorganic compounds) to generate non-centrosymmetric crystal structures, was demonstrated as a promising system for searching new IR NLO crystals with excellent optical properties, and a great many NLO-active chalcophosphates were reasonably designed and fabricated. To advance the targeted design of high-performance IR NLO crystals, this review provides a systematic and up-to-date summary on the abundant structural and chemical diversities of chalcophosphates, with a particular emphasis on the connection modes of distinguished [PxQy] units; and the efficient progress on the structural design that achieved in the thiophosphate-, selenophosphate-, and mixed anionic-based chalcophosphate IR NLO candidates in recent years. Finally, the upcoming opportunities and challenges in the captivating fields were discussed.
{"title":"Chalcophosphates: A plentiful source of infrared nonlinear optical materials","authors":"Yingying Kong , Guansong Zheng , Yinxia Du , Junjie Li , Shilie Pan","doi":"10.1016/j.ccr.2025.216524","DOIUrl":"10.1016/j.ccr.2025.216524","url":null,"abstract":"<div><div>Developing high-performance nonlinear optical (NLO) crystals is an urgent need for advanced photoelectric technologies. However, the discovery of novel infrared (IR) NLO materials with desired properties is challenging. Chalcophosphate, combining the structural advantages of chalcogenide & phosphate, and showing a high probability (∼30 %, much higher than the one of ∼15 % in the inorganic compounds) to generate non-centrosymmetric crystal structures, was demonstrated as a promising system for searching new IR NLO crystals with excellent optical properties, and a great many NLO-active chalcophosphates were reasonably designed and fabricated. To advance the targeted design of high-performance IR NLO crystals, this review provides a systematic and up-to-date summary on the abundant structural and chemical diversities of chalcophosphates, with a particular emphasis on the connection modes of distinguished [P<sub>x</sub>Q<sub>y</sub>] units; and the efficient progress on the structural design that achieved in the thiophosphate-, selenophosphate-, and mixed anionic-based chalcophosphate IR NLO candidates in recent years. Finally, the upcoming opportunities and challenges in the captivating fields were discussed.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"533 ","pages":"Article 216524"},"PeriodicalIF":20.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143496182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-26DOI: 10.1016/j.ccr.2025.216557
Lishan Wang , Qing He , Jianping Man , Yechen Gao , Guangming Zhou , Hongwei Si , Kai Yang , Lin Hu , Pei Pei
Internal radionuclide therapy (IRT) is a crucial component of cancer radiotherapy, focusing on delivering radionuclides to the tumor site via an optimal carrier and using high-energy radiation (including α particles, β particles, γ rays, and Auger electrons) to kill tumor cells. To further enhance the efficacy and safety of IRT, developing new bio-carriers to optimize the stable and efficient labelling, targeting delivery efficiency, biosafety, and multi-functionality of radionuclides has become a current research focus. In this review, we first briefly revisit the commonly used radionuclide delivery carriers in clinical practice, including antibodies, peptides, microspheres, and discuss their associated challenges. Subsequently, we focus on the development and research progress of novel bio-carriers, analyzing their roles and mechanisms in optimizing radionuclide labelling, delivery, and enhancing the efficacy of IRT. Finally, the review provides insights into the existing challenges faced in the field and suggests potential future research directions. Our work aims to advance the use of radionuclides in cancer radiotherapy with innovative bio-carriers, offering theoretical support and a vision for developing highly multifunctional and clinically useful bio-carriers.
{"title":"Novel bio-carriers for radionuclide delivery in cancer radiotherapy","authors":"Lishan Wang , Qing He , Jianping Man , Yechen Gao , Guangming Zhou , Hongwei Si , Kai Yang , Lin Hu , Pei Pei","doi":"10.1016/j.ccr.2025.216557","DOIUrl":"10.1016/j.ccr.2025.216557","url":null,"abstract":"<div><div>Internal radionuclide therapy (IRT) is a crucial component of cancer radiotherapy, focusing on delivering radionuclides to the tumor site via an optimal carrier and using high-energy radiation (including α particles, β particles, γ rays, and Auger electrons) to kill tumor cells. To further enhance the efficacy and safety of IRT, developing new bio-carriers to optimize the stable and efficient labelling, targeting delivery efficiency, biosafety, and multi-functionality of radionuclides has become a current research focus. In this review, we first briefly revisit the commonly used radionuclide delivery carriers in clinical practice, including antibodies, peptides, microspheres, and discuss their associated challenges. Subsequently, we focus on the development and research progress of novel bio-carriers, analyzing their roles and mechanisms in optimizing radionuclide labelling, delivery, and enhancing the efficacy of IRT. Finally, the review provides insights into the existing challenges faced in the field and suggests potential future research directions. Our work aims to advance the use of radionuclides in cancer radiotherapy with innovative bio-carriers, offering theoretical support and a vision for developing highly multifunctional and clinically useful bio-carriers.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"533 ","pages":"Article 216557"},"PeriodicalIF":20.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nanozymes, a type of nanomaterials with enzyme-like activity, have attracted growing attention in recent years due to their remarkable stability, tunable catalytic performance, multifunctionalities, and cost-effectiveness. Although significant progress has been made in the past decade, designing nanozymes with high selectivity, excellent catalytic activity, and new types of catalytic activities beyond oxidation-reduction reactions remains highly challenging. This is primarily due to the difficulties in fabricating well-defined nanozymes and precisely tailoring the microenvironment of catalytic sites at atomic level. Metal-organic frameworks (MOFs) with enzyme-mimicking activities (MOFzymes) offer several advantages over other nanozymes, including well-defined molecular structure and catalytic sites, high porosity, and large surface areas. MOFzymes mainly mimic various oxidoreductases, such as oxidase, peroxidase, catalase, superoxide dismutase, and glutathione peroxidase, making them suitable for various biomedical applications. In this article, the structures and properties of MOFzymes and the latest developments are thoroughly discussed. We particularly focus on the physical and chemical methods for microenvironment regulation of MOFzymes, and the working mechanisms. Furthermore, the applications of MOFzymes for biosensing, cancer therapy, antibacterial therapy, and anti-inflammatory therapy are described. Finally, we discuss the future opportunities and challenges of MOFzymes.
{"title":"Microenvironment engineering of MOFzymes for biomedical applications","authors":"Xiaoping Zhao , Rui Gao , Heng Sun , Peng Chen , Haixue Zheng , Lingjie Meng","doi":"10.1016/j.ccr.2025.216539","DOIUrl":"10.1016/j.ccr.2025.216539","url":null,"abstract":"<div><div>Nanozymes, a type of nanomaterials with enzyme-like activity, have attracted growing attention in recent years due to their remarkable stability, tunable catalytic performance, multifunctionalities, and cost-effectiveness. Although significant progress has been made in the past decade, designing nanozymes with high selectivity, excellent catalytic activity, and new types of catalytic activities beyond oxidation-reduction reactions remains highly challenging. This is primarily due to the difficulties in fabricating well-defined nanozymes and precisely tailoring the microenvironment of catalytic sites at atomic level. Metal-organic frameworks (MOFs) with enzyme-mimicking activities (MOFzymes) offer several advantages over other nanozymes, including well-defined molecular structure and catalytic sites, high porosity, and large surface areas. MOFzymes mainly mimic various oxidoreductases, such as oxidase, peroxidase, catalase, superoxide dismutase, and glutathione peroxidase, making them suitable for various biomedical applications. In this article, the structures and properties of MOFzymes and the latest developments are thoroughly discussed. We particularly focus on the physical and chemical methods for microenvironment regulation of MOFzymes, and the working mechanisms. Furthermore, the applications of MOFzymes for biosensing, cancer therapy, antibacterial therapy, and anti-inflammatory therapy are described. Finally, we discuss the future opportunities and challenges of MOFzymes.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"533 ","pages":"Article 216539"},"PeriodicalIF":20.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-26DOI: 10.1016/j.ccr.2025.216548
Pu Chen , Jiawen Zhao , Dongmi Li , Yu Zhang , Chunxuan Qi , Hai-Tao Feng , Ben Zhong Tang
Fungi are closely related to people's production and living. It is very crucial to achieve the accurate detection and effective elimination of fungi in the reasonable utilization of fungi and the efficient treatment of fungi-infected diseases. Aggregation-induced emission (AIE) luminogens (AIEgens), which can overcome the aggregation-caused quenching (ACQ) effect and emit bright emission in aggregated states, have great potential in imaging, detection and therapy with high photostability and abundant generation of reactive oxygen species (ROS). In this review, we summarized relevant studies on fungal detection and elimination that utilize AIEgens. In fungal detection, some works involving AIEgens in fungal viability evaluation, imaging, activity assessment, discrimination and quantification were described. In fungal elimination, several works in fungal killing due to dark toxicity or phototoxicity of AIEgens in vitro were represented, and some works in fungal elimination and treatment of superficial fungal infection in vivo relying on phototoxicity of AIEgens were depicted. At the end of the review, we conclude the structural features of AIEgens for binding to fungi and present the existing challenges in this field.
{"title":"Fungal detection and elimination based on AIEgens","authors":"Pu Chen , Jiawen Zhao , Dongmi Li , Yu Zhang , Chunxuan Qi , Hai-Tao Feng , Ben Zhong Tang","doi":"10.1016/j.ccr.2025.216548","DOIUrl":"10.1016/j.ccr.2025.216548","url":null,"abstract":"<div><div>Fungi are closely related to people's production and living. It is very crucial to achieve the accurate detection and effective elimination of fungi in the reasonable utilization of fungi and the efficient treatment of fungi-infected diseases. Aggregation-induced emission (AIE) luminogens (AIEgens), which can overcome the aggregation-caused quenching (ACQ) effect and emit bright emission in aggregated states, have great potential in imaging, detection and therapy with high photostability and abundant generation of reactive oxygen species (ROS). In this review, we summarized relevant studies on fungal detection and elimination that utilize AIEgens. In fungal detection, some works involving AIEgens in fungal viability evaluation, imaging, activity assessment, discrimination and quantification were described. In fungal elimination, several works in fungal killing due to dark toxicity or phototoxicity of AIEgens <em>in vitro</em> were represented, and some works in fungal elimination and treatment of superficial fungal infection <em>in vivo</em> relying on phototoxicity of AIEgens were depicted. At the end of the review, we conclude the structural features of AIEgens for binding to fungi and present the existing challenges in this field.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"533 ","pages":"Article 216548"},"PeriodicalIF":20.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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