Coordination Chemistry Reviews最新文献

The tumor vasculature plays a crucial role in promoting tumor growth and metastasis, showcasing heterogeneity in terms of tissue composition, functionality, and structural characteristics. The main limitation of traditional anti-tumor therapy arises from the disordered occlusion and structural abnormalities present within the vascular network of the tumor, which create a bottleneck effect. Hence, the advancement of nanomedicine techniques targeting the tumor vascular system offer a fresh and exciting direction for the treatment of cancer. In this review, the intricate dynamics between the tumor microenvironment (TME) and the tumor vasculature is explored with a focus on the functions of hypoxia, increased angiogenic factor expression, and inflammatory cytokines in the TME. Furthermore, this review provides a comprehensive analysis of various vascular-related treatments, delving into the mechanisms behind each approach. Specifically, the recent advancements in nanomedicines targeting for therapeutic strategies are highlighted, namely anti-tumor angiogenic therapy, tumor vascular structure disruption, tumor vasculature normalization, and embolization therapy. Lastly, an overview of the challenges and prospects associated with tumor vascular therapy using nanomedicines is presented.

Biomass has garnered considerable attention as a globally available, low-cost, and renewable carbon-neutral source in recent decades. The inherent complexity and stability of biomass made the efficient utilization of biomass under mild conditions a daunting challenge. Recently, significant progress has been made in biomass conversion by functionalized polyoxometalates (POMs) catalysts. In this review, the recent advancements in the synthesis of furan derivatives such as 5-hydroxymethylfurfural (HMF), 2-furaldehyde (furfural), 2,5-diformylfuran (DFF), 5-ethoxymethylfurfural (EMF), and other fine chemicals such as formic acid (FA), alkyl levulinates, polyols and organic acids from renewable inedible biomass by using POMs-based catalytic systems were summarized. The future of POMs-catalyzed sustainable chemistry lies in the development of functionalized task-specific POMs as green catalysts, and the rational design of novel reactions that would ultimately pave the pathway for the establishment of green, effective, inexpensive, and sustainable technologies.

Excessive use of carbonaceous fuels causes significant CO₂ emissions so that more environmental issues are occurring. Reduction of CO₂ to Carbonaceous compounds using sunlight is a viable strategy to address this problem. Metal-organic frameworks (MOFs) can effectively increase the interaction between CO₂ molecules and active sites thanks to its extensive specific surface area and adjustable pore configuration. Concurrently, the synergistic effect of transition metal and organic ligands in MOFs also regulate the electron transfer process and promote photoionization efficiency. These properties make MOFs materials get great applications to catalyze carbon dioxide reduction as photocatalyst. Moreover, the MOFs materials with adjustable components carry different metal ions and ligands to form diverse MOFs based photocatalyst, which provides more possibilities for the preparation of highly active catalysts. Currently, the primary products of MOFs based photocatalyst are CO, CH₄ and other C₁ products. In this perspective, we review the fundamental mechanisms of the photocatalytic CO₂ reduction reaction and summarize the current research findings on MOFs based photocatalyst within the domain by classifying the reduction products. Finally, we present and prospect the outlook based on current research progress. The primary purpose of this paper is to discuss the relationship between the MOFs materials and product by summarizing the generation rate and selectivity for different products, and to offer the guiding role for the further advancement of catalysts with excellent catalytic activity for efficient C₂₊ products.

Recent years, cell-based therapeutics are undergoing explosive growth in the modern biomedical field. The ability for non-invasively and real-timely tracking and understanding the fate and functionality of cells in vivo after transplantation is vitally important for safe and effective treatments in cell-based therapeutics or exploring physiological and pathological processes in biological systems. Optical imaging in the near-infrared window (700–1700 nm) is regarded as the most promising imaging modality for in vivo cell tracking in both fundamental scientific research and clinical practice. Very recently, in vivo cell tracking with NIR optical imaging has made significant advances in determining the fate and trafficking of biologically active cells benefiting from the flourishing development of NIR optical imaging agents. In this review, we summarize the most recent research advances in this field of non-invasive cell tracking in vivo with NIR optical imaging for modern biomedical applications. We also describe the basic concepts and principles of intravital cell tracking, explain different labeling manners for cell tracking, and highlight recent representative examples for the application of such cell tracking technologies in various animal models. Furthermore, the fundamental challenges and development perspectives for in vivo cell tracking are also discussed.

Environmental pollution has become a major global issue, worsened by the rapid growth of industries. Traditional pollutant detection methods often require high operational temperatures and exhibit limited sensitivity and selectivity. Quartz crystal microbalance with dissipation monitoring (QCM-D) sensors have emerged as a promising alternative, offering high sensitivity, affordability, and precise measurements at room temperature. This review explores the integration of metal-organic frameworks (MOFs) and covalent organic frameworks (COFs), into QCM sensors to boost their performance. MOFs, with their high porosity and surface tunability, and COFs, known for their exceptional chemical and thermal stability, are examined for applications such as gas detection, heavy metal sensing, and thin film measurements. Our findings indicate that MOF/COF substrates on QCM electrodes enhance assay efficiency and sensor sensitivity, offering quick responses, good stability, compact size, and nanogram-level detection. Enhancements in porosity, sensitivity, and selectivity, along with integration with other methods, promise significant advancements. We discuss the synthesis methods, properties, and advantages of MOF- and COF-based QCM sensors. Additionally, we address the challenges and future perspectives of these advanced materials in QCM sensor technology, aiming to pave the way for innovative solutions in pollutant detection and environmental safety.

Hydrogen (H₂) emerges as a highly promising contender for replacing conventional fossil fuels due to its high combustion heat value and net-zero greenhouse gas emission. Photocatalytic H₂ generation through semiconductor-based water splitting represents a clean and sustainable technology in the field. Developing highly efficient and abundant source semiconductor materials, along with co-catalysts, is paramount in achieving the industrial-level H₂ evolution by photocatalysis technology. In recent years, transition-metal phosphides (TMPs) have emerged as powerful co-catalysts for photocatalytic reactions due to their cost-effectiveness, abundant reserves in the earth's crust, and favorable physicochemical properties, thus offering a viable alternative to conventional precious metal materials. In this review, we first provide a concise historical overview and outline the structure of TMPs. The synthetic strategies of TMPs are subsequently systematically analyzed based on diverse phosphorus sources. Additionally, this review provides a comprehensive summary of the recent research endeavors conducted on TMPs as potential photocatalytic co-catalysts for efficient hydrogen generation through photocatalysis. Eventually, this review briefly addresses the prevailing key concerns, proposed countermeasures, and forthcoming challenges associated with enhancing the efficiency of photocatalytic H₂ evolution in TMPs.

Emerging sonodynamic therapy strategies shed light on conquering oxygen dependence and penetration restriction in photodynamic therapy for non-invasive tumor treatments. During the flourishing of novel sonosensitizer construction strategies, the introduction of metals broadens the fabrication modalities of sonosensitizer and perfects the presently insufficient therapeutic effects of single-modality sonodynamic therapy. In this review, cutting-edge metal-based sonosensitizers are categorized according to the utilized metals to demonstrate the unique role of different metals in facilitating sensitizer construction, optimizing sonodynamic performance, introducing synergistic treatments, and reshaping tumor microenvironment. The thread throughout the text is the specific mechanisms activated by the introduction of metals and their versatile functionalities in boosting sonodynamic therapy. Furthermore, state-of-the-art approaches to initiate systemic anticancer immunity by metal-based sonosensitizers are highlighted to inspire the versatile application of metal-mediated sonodynamic effects. Finally, the challenges and perspectives are revealed, aiming to provide insights into using metals in sonodynamic therapy and incorporating sonodynamic therapy into multi-modal anticancer treatments.

Electro-induced water splitting module is a fascinating strategy for the conversion of electricity into scalable and clean H₂ as a future energy carrier and has significantly attracted the attention of the scientific community. Despite countless research on electrolyzers, cost-effective and durable electrode materials with high conversion efficiency remain a challenge and dream in this quest. This critical review is devoted to systemically presenting the upsurge of recently and rationally explored highly stable benchmark electrocatalysts (both noble and non-noble) to understand the design principles, performances, and compelling reasons/chemistry behind the enhanced catalytic potential over traditional electrocatalysts for half-cell oxygen evolution reaction (OER) and hydrogen evolution reaction (HER). Moreover, the highly stable electrode materials (at least ≥50 h) and their bi-functional conduct evaluated in prototype electrolyzer integrated with photovoltaic (PV) or batteries at the laboratory level are discussed, yet an untold and unsummarized story in electrochemical water splitting. Next, the current status of this technology, socio-economic challenges, possible solutions, key considerations and fundamental principles/concepts behind the water splitting conversion scheme are outlined from the point of practical application. Typical challenges remain regarding identifying, preparing, and scaling the potential electrocatalysts, but the foundations are now strong, and the outlook is visible for this exciting next-generation technology.

CO₂ has attracted significant attention due to its effect on global warming. Meanwhile, CO₂ is also essential for the modern agricultural, food, environmental, oil, and chemical industries. Thus, the rapid and selective detection and measurement of CO₂ is urgent. Since the simplicity, sensitivity, and especially non-destructive detection capacities of probes based on fluorescent molecules, fluorescence-based detecting techniques have become vital. In the past few years, remarkable developments in CO₂ probes have been made, which markedly advance the environment, industry, and medical field. This review highlights the recent advances in various functional materials and small-molecule fluorescent probes for visualizing CO₂. These fluorescent probes' design strategies, recognition mechanisms, optical properties, and practical applications were systematically discussed. This review is expected to promote the development of the CO₂ relative field, not only in the fluorescent probe but also in the environment and industry.

Spin crossover (SCO) complexes are classic magnetic bistable materials with various promising potential applications, such as data storage, displays, switches, actuators and sensors. SCO clusters possess intriguing spin state topologies and provide a good platform to study multi-step SCO behavior and quantum cellular automata. This review focuses on the recent developments of discrete SCO clusters and cluster-based SCO coordination polymers. The synthesis, structural characters, SCO behaviors and other function are systematically analyzed for the representative SCO clusters. Their design principles and synthetic strategies are also summarized, which will help to design multifunctional discrete SCO clusters and cluster-based metal-organic frameworks.